| Year |
Citation |
Score |
| 2020 |
Mizukami Y, Moriya A, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M. Incorporation of Gelatin Microspheres into HepG2 Human Hepatocyte Spheroids for Functional Improvement through Improved Oxygen Supply to Spheroid Core. Biological & Pharmaceutical Bulletin. 43: 1220-1225. PMID 32741942 DOI: 10.1248/Bpb.B20-00141 |
0.303 |
|
| 2020 |
Liao W, Akahira S, Hara RI, Wada T, Kusamori K, Takakura Y, Nishikawa M. Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA. Biological & Pharmaceutical Bulletin. 43: 1188-1195. PMID 32741939 DOI: 10.1248/Bpb.B20-00052 |
0.36 |
|
| 2020 |
Liu W, Takahashi Y, Morishita M, Nishikawa M, Takakura Y. Development of CD40L-modified tumor small extracellular vesicles for effective induction of antitumor immune response. Nanomedicine (London, England). 15: 1641-1652. PMID 32664826 DOI: 10.2217/Nnm-2020-0071 |
0.304 |
|
| 2020 |
Maezawa T, Ohtsuki S, Hidaka K, Sugiyama H, Endo M, Takahashi Y, Takakura Y, Nishikawa M. DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells. Nanoscale. 12: 14818-14824. PMID 32633313 DOI: 10.1039/D0Nr02361B |
0.33 |
|
| 2020 |
Matsumoto A, Asuka M, Takahashi Y, Takakura Y. Antitumor immunity by small extracellular vesicles collected from activated dendritic cells through effective induction of cellular and humoral immune responses. Biomaterials. 252: 120112. PMID 32422494 DOI: 10.1016/J.Biomaterials.2020.120112 |
0.304 |
|
| 2020 |
Takakura Y, Matsumoto A, Takahashi Y. Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical and Pharmacokinetic Challenges. Biological & Pharmaceutical Bulletin. 43: 576-583. PMID 32238700 DOI: 10.1248/Bpb.B19-00831 |
0.323 |
|
| 2020 |
Matsumoto A, Takahashi Y, Chang HY, Wu YW, Yamamoto A, Ishihama Y, Takakura Y. Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance. Journal of Extracellular Vesicles. 9: 1696517. PMID 31807238 DOI: 10.1080/20013078.2019.1696517 |
0.308 |
|
| 2019 |
Ohtsuki S, Shiba Y, Maezawa T, Hidaka K, Sugiyama H, Endo M, Takahashi Y, Takakura Y, Nishikawa M. Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake. Nanoscale. 11: 23416-23422. PMID 31799532 DOI: 10.1039/C9Nr08695A |
0.328 |
|
| 2019 |
Matsumoto A, Takahashi Y, Ariizumi R, Nishikawa M, Takakura Y. Development of DNA-anchored assembly of small extracellular vesicle for efficient antigen delivery to antigen presenting cells. Biomaterials. 225: 119518. PMID 31586864 DOI: 10.1016/J.Biomaterials.2019.119518 |
0.376 |
|
| 2019 |
Komura F, Takahashi Y, Inoue T, Takakura Y, Nishikawa M. Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8. Nucleic Acid Therapeutics. PMID 31329033 DOI: 10.1089/Nat.2019.0787 |
0.357 |
|
| 2018 |
Umeki Y, Saito M, Kusamori K, Tsujimura M, Nishimura M, Takahashi Y, Takakura Y, Nishikawa M. Combined encapsulation of a tumor antigen and immune cells using a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30219278 DOI: 10.1016/J.Jconrel.2018.09.007 |
0.364 |
|
| 2018 |
Yamashita T, Takahashi Y, Takakura Y. Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Biological & Pharmaceutical Bulletin. 41: 835-842. PMID 29863072 DOI: 10.1248/Bpb.B18-00133 |
0.323 |
|
| 2018 |
Araie Y, Takahashi Y, Takahashi Y, Takakura Y, Nishikawa M. Enhanced Activity of Immunosuppressive Oligodeoxynucleotides by Incorporating Them into Hexapod-Like Nanostructured DNA. Biological & Pharmaceutical Bulletin. 41: 564-569. PMID 29607929 DOI: 10.1248/Bpb.B17-00864 |
0.32 |
|
| 2018 |
Charoenviriyakul C, Takahashi Y, Morishita M, Nishikawa M, Takakura Y. Role of extracellular vesicle surface proteins in the pharmacokinetics of extracellular vesicles. Molecular Pharmaceutics. PMID 29382201 DOI: 10.1021/Acs.Molpharmaceut.7B00950 |
0.302 |
|
| 2017 |
Tanaka Y, Nishikawa M, Mizukami Y, Kusamori K, Ogino Y, Nishimura S, Shimizu K, Konishi S, Takahashi Y, Takakura Y. Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 29225184 DOI: 10.1016/J.Jconrel.2017.12.006 |
0.327 |
|
| 2017 |
Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y. Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins. International Journal of Pharmaceutics. 536: 310-317. PMID 29217470 DOI: 10.1016/J.Ijpharm.2017.12.010 |
0.308 |
|
| 2017 |
Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M. Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. Scientific Reports. 7: 13661. PMID 29057947 DOI: 10.1038/S41598-017-13890-3 |
0.369 |
|
| 2017 |
Morishita M, Takahashi Y, Nishikawa M, Ariizumi R, Takakura Y. Enhanced class I tumor antigen presentation via cytosolic delivery of exosomal cargos by tumor cell-derived exosomes displaying a pH-sensitive fusogenic peptide. Molecular Pharmaceutics. PMID 28977747 DOI: 10.1021/Acs.Molpharmaceut.7B00760 |
0.323 |
|
| 2017 |
Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y, Nishikawa M. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. Journal of Drug Targeting. 1-34. PMID 28972806 DOI: 10.1080/1061186X.2017.1387789 |
0.399 |
|
| 2017 |
Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M. DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy. Biomaterials. 146: 136-145. PMID 28918263 DOI: 10.1016/J.Biomaterials.2017.09.014 |
0.338 |
|
| 2017 |
Takahashi Y, Nishikawa M, Takakura Y. In Vivo Tracking of Extracellular Vesicles in Mice Using Fusion Protein Comprising Lactadherin and Gaussia Luciferase. Methods in Molecular Biology (Clifton, N.J.). 1660: 245-254. PMID 28828662 DOI: 10.1007/978-1-4939-7253-1_20 |
0.319 |
|
| 2017 |
Umeki Y, Saito M, Takahashi Y, Takakura Y, Nishikawa M. Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response. Advanced Healthcare Materials. PMID 28726304 DOI: 10.1002/Adhm.201700355 |
0.343 |
|
| 2017 |
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y. Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Cancer Science. PMID 28667694 DOI: 10.1111/Cas.13310 |
0.33 |
|
| 2017 |
Nishikawa T, Tanaka Y, Nishikawa M, Kusamori K, Mizuno N, Mizukami Y, Ogino Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y. Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice. Biotechnology Journal. PMID 28439989 DOI: 10.1002/Biot.201600513 |
0.331 |
|
| 2017 |
Takahashi Y, Maezawa T, Araie Y, Takahashi Y, Takakura Y, Nishikawa M. In vitro and in vivo Stimulation of Toll-like Receptor 9 by CpG Oligodeoxynucleotides Incorporated into Polypod-like DNA Nanostructures. Journal of Pharmaceutical Sciences. PMID 28385547 DOI: 10.1016/J.Xphs.2017.03.028 |
0.36 |
|
| 2017 |
Morishita M, Takahashi Y, Nishikawa M, Takakura Y. Pharmacokinetics of Exosomes-an Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics. Journal of Pharmaceutical Sciences. PMID 28283433 DOI: 10.1016/J.Xphs.2017.02.030 |
0.327 |
|
| 2017 |
Nishikawa T, Tanaka Y, Nishikawa M, Ogino Y, Kusamori K, Mizuno N, Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y. Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size. Biological & Pharmaceutical Bulletin. 40: 334-338. PMID 28250275 DOI: 10.1248/Bpb.B16-00833 |
0.305 |
|
| 2016 |
Ando M, Fujimoto M, Takahashi Y, Nishikawa M, Hamana A, Takakura Y. Targeted delivery of interferon gamma using a recombinant fusion protein of a fibrin-clot binding peptide with interferon gamma for cancer gene therapy. Journal of Pharmaceutical Sciences. PMID 27939375 DOI: 10.1016/J.Xphs.2016.11.018 |
0.322 |
|
| 2016 |
Ishii-Mizuno Y, Umeki Y, Onuki Y, Watanabe H, Takahashi Y, Takakura Y, Nishikawa M. Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan. International Journal of Pharmaceutics. PMID 27884715 DOI: 10.1016/J.Ijpharm.2016.11.048 |
0.327 |
|
| 2016 |
Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y. Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA. Biomaterials. 111: 55-65. PMID 27723556 DOI: 10.1016/J.Biomaterials.2016.09.031 |
0.368 |
|
| 2016 |
Charoenviriyakul C, Takahashi Y, Morishita M, Matsumoto A, Nishikawa M, Takakura Y. Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 27720897 DOI: 10.1016/J.Ejps.2016.10.009 |
0.337 |
|
| 2016 |
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y. Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages. Journal of Pharmaceutical Sciences. PMID 27649887 DOI: 10.1016/J.Xphs.2016.07.022 |
0.351 |
|
| 2016 |
Hamana A, Takahashi Y, Nishikawa M, Takakura Y. Interferon-inducible Mx promoter-driven, long-term transgene expression system of interferon-β for cancer gene therapy. Human Gene Therapy. PMID 27496321 DOI: 10.1089/Hum.2016.023 |
0.326 |
|
| 2016 |
Sanada Y, Shiomi T, Okobira T, Tan M, Nishikawa M, Akiba I, Takakura Y, Sakurai K. Polypod-shaped DNAs: Small Angle X-ray Scattering and Immunostimulatory Activity. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 27007061 DOI: 10.1021/Acs.Langmuir.6B00398 |
0.311 |
|
| 2016 |
Yin Y, Takahashi Y, Hamana A, Nishikawa M, Takakura Y. Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer. Gene Therapy. PMID 26966861 DOI: 10.1038/Gt.2016.26 |
0.351 |
|
| 2016 |
Takahashi Y, Nishikawa M, Takakura Y. Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 136: 49-53. PMID 26725667 DOI: 10.1248/Yakushi.15-00227-2 |
0.345 |
|
| 2015 |
Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M. Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26364795 DOI: 10.1016/J.Nano.2015.08.004 |
0.373 |
|
| 2015 |
Zang L, Nishikawa M, Ando M, Takahashi Y, Takakura Y. Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver. Pharmaceutics. 7: 199-212. PMID 26262639 DOI: 10.3390/Pharmaceutics7030199 |
0.312 |
|
| 2015 |
Ohtsuki S, Matsuzaki N, Mohri K, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Ishiyama K, Kadowaki N, Takakura Y, Nishikawa M. Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells. Nucleic Acid Therapeutics. PMID 26222130 DOI: 10.1089/Nat.2014.0524 |
0.337 |
|
| 2015 |
Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M. Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells. Biomacromolecules. 16: 1095-101. PMID 25775113 DOI: 10.1021/Bm501731F |
0.335 |
|
| 2015 |
Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto A, Charoenviriyakul C, Takakura Y. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. Journal of Extracellular Vesicles. 4: 26238. PMID 25669322 DOI: 10.3402/Jev.V4.26238 |
0.354 |
|
| 2015 |
Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M. Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice. Journal of Controlled Release : Official Journal of the Controlled Release Society. 200: 52-9. PMID 25553824 DOI: 10.1016/J.Jconrel.2014.12.040 |
0.348 |
|
| 2015 |
Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai T, Saji H, Takakura Y. Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. Journal of Pharmaceutical Sciences. 104: 705-13. PMID 25393546 DOI: 10.1002/Jps.24251 |
0.327 |
|
| 2015 |
Umeki Y, Mohri K, Kawasaki Y, Watanabe H, Takahashi R, Takahashi Y, Takakura Y, Nishikawa M. Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-Based Hydrogel with Adjuvant Activity Advanced Functional Materials. 25: 5758-5767. DOI: 10.1002/Adfm.201502139 |
0.373 |
|
| 2014 |
Ando M, Takahashi Y, Yamashita T, Fujimoto M, Nishikawa M, Watanabe Y, Takakura Y. Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice. Molecular Therapy. Methods & Clinical Development. 1: 14023. PMID 26015966 DOI: 10.1038/Mtm.2014.23 |
0.364 |
|
| 2014 |
Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y. Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. Gene Therapy. 21: 794-801. PMID 24919418 DOI: 10.1038/Gt.2014.54 |
0.336 |
|
| 2014 |
Yin Y, Takahashi Y, Ebisuura N, Nishikawa M, Takakura Y. Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression. The Journal of Gene Medicine. 16: 97-106. PMID 24807854 DOI: 10.1002/Jgm.2763 |
0.303 |
|
| 2014 |
Kiyota T, Takahashi Y, Watcharanurak K, Nishikawa M, Ohara S, Ando M, Watanabe Y, Takakura Y. Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages. Molecular Pharmaceutics. 11: 1542-9. PMID 24708139 DOI: 10.1021/Mp4007216 |
0.315 |
|
| 2014 |
Mohri K, Nishikawa M, Takahashi Y, Takakura Y. DNA nanotechnology-based development of delivery systems for bioactive compounds. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 58: 26-33. PMID 24694593 DOI: 10.1016/J.Ejps.2014.03.002 |
0.336 |
|
| 2014 |
Nishikawa M, Ogawa K, Umeki Y, Mohri K, Kawasaki Y, Watanabe H, Takahashi N, Kusuki E, Takahashi R, Takahashi Y, Takakura Y. Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 180: 25-32. PMID 24530618 DOI: 10.1016/J.Jconrel.2014.02.001 |
0.35 |
|
| 2014 |
Uno S, Nishikawa M, Mohri K, Umeki Y, Matsuzaki N, Takahashi Y, Fujita H, Kadowaki N, Takakura Y. Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 765-74. PMID 24333587 DOI: 10.1016/J.Nano.2013.11.017 |
0.387 |
|
| 2014 |
Takahashi Y, Nishikawa M, Takakura Y. In vivo fate of exogenously-administered exosomes Drug Delivery System. 29: 116-124. DOI: 10.2745/Dds.29.116 |
0.304 |
|
| 2013 |
Takahashi Y, Nishikawa M, Shinotsuka H, Matsui Y, Ohara S, Imai T, Takakura Y. Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. Journal of Biotechnology. 165: 77-84. PMID 23562828 DOI: 10.1016/J.Jbiotec.2013.03.013 |
0.345 |
|
| 2013 |
Miyakawa N, Nishikawa M, Takahashi Y, Ando M, Misaka M, Watanabe Y, Takakura Y. Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity. Journal of Pharmaceutical Sciences. 102: 3110-8. PMID 23463584 DOI: 10.1002/Jps.23493 |
0.343 |
|
| 2012 |
Ando M, Takahashi Y, Nishikawa M, Takakura Y. [Control of spatiotemporal distribution of interferon γ by genetically fusing functional peptides]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 132: 1399-406. PMID 23208047 DOI: 10.1248/Yakushi.12-00235-4 |
0.36 |
|
| 2012 |
Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y. Controlling the kinetics of interferon transgene expression for improved gene therapy. Journal of Drug Targeting. 20: 764-9. PMID 22994266 DOI: 10.3109/1061186X.2012.716848 |
0.323 |
|
| 2012 |
Mohri K, Takahashi N, Nishikawa M, Kusuki E, Shiomi T, Takahashi Y, Takakura Y. Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures. Journal of Controlled Release : Official Journal of the Controlled Release Society. 163: 285-92. PMID 22902518 DOI: 10.1016/J.Jconrel.2012.08.001 |
0.345 |
|
| 2012 |
Yoshida H, Nishikawa M, Yasuda S, Toyota H, Kiyota T, Takahashi Y, Takakura Y. Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA. Cytokine. 60: 162-70. PMID 22809727 DOI: 10.1016/J.Cyto.2012.06.237 |
0.33 |
|
| 2012 |
Rattanakiat S, Nishikawa M, Takakura Y. Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 47: 352-8. PMID 22771546 DOI: 10.1016/J.Ejps.2012.06.015 |
0.337 |
|
| 2012 |
Mohri K, Nishikawa M, Takahashi N, Shiomi T, Matsuoka N, Ogawa K, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y. Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells. Acs Nano. 6: 5931-40. PMID 22721419 DOI: 10.1021/Nn300727J |
0.34 |
|
| 2012 |
Guan X, Guan X, Nishikawa M, Nishikawa M, Li H, Li H, Rei T, Rei T, Takahashi Y, Takahashi Y, Takakura Y, Takakura Y. Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice. Human Vaccines & Immunotherapeutics. 8: 194-200. PMID 22426379 DOI: 10.4161/Hv.18370 |
0.342 |
|
| 2012 |
Ando M, Takahashi Y, Nishikawa M, Watanabe Y, Takakura Y. Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy. The Journal of Gene Medicine. 14: 288-95. PMID 22359360 DOI: 10.1002/Jgm.2616 |
0.331 |
|
| 2012 |
Takahashi Y, Nishikawa M, Takakura Y. Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector. Frontiers in Bioscience (Scholar Edition). 4: 133-41. PMID 22202048 DOI: 10.2741/256 |
0.339 |
|
| 2011 |
Nishizaki C, Nishikawa M, Yata T, Yamada T, Takahashi Y, Oku M, Yurimoto H, Sakai Y, Nakanishi K, Takakura Y. Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice. Free Radical Biology & Medicine. 51: 773-9. PMID 21664457 DOI: 10.1016/J.Freeradbiomed.2011.05.025 |
0.303 |
|
| 2011 |
Yoshida H, Nishikawa M, Kiyota T, Toyota H, Takakura Y. Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice. Free Radical Biology & Medicine. 51: 424-31. PMID 21571065 DOI: 10.1016/J.Freeradbiomed.2011.04.035 |
0.314 |
|
| 2011 |
Takahashi Y, Nishikawa M, Takiguchi N, Suehara T, Takakura Y. Saturation of transgene protein synthesis from mRNA in cells producing a large number of transgene mRNA. Biotechnology and Bioengineering. 108: 2380-9. PMID 21520018 DOI: 10.1002/Bit.23179 |
0.31 |
|
| 2011 |
Zang L, Nishikawa M, Machida K, Ando M, Takahashi Y, Watanabe Y, Takakura Y. Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy. Gene Therapy. 18: 891-897. PMID 21451577 DOI: 10.1038/Gt.2011.35 |
0.32 |
|
| 2011 |
Yoshida H, Nishikawa M, Kiyota T, Uno S, Toyota H, Takahashi R, Narita M, Takakura Y. 5'-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages. European Journal of Immunology. 41: 425-36. PMID 21268012 DOI: 10.1002/Eji.201040396 |
0.324 |
|
| 2011 |
Miyakawa N, Nishikawa M, Takahashi Y, Ando M, Misaka M, Watanabe Y, Takakura Y. Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice. Journal of Pharmaceutical Sciences. 100: 2350-7. PMID 21246562 DOI: 10.1002/Jps.22473 |
0.363 |
|
| 2011 |
Nishikawa M, Mizuno Y, Mohri K, Matsuoka N, Rattanakiat S, Takahashi Y, Funabashi H, Luo D, Takakura Y. Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice. Biomaterials. 32: 488-94. PMID 20932569 DOI: 10.1016/J.Biomaterials.2010.09.013 |
0.352 |
|
| 2010 |
Nishikawa M, Takahashi Y, Takakura Y. [Optimization of gene therapy effect by spaciotemporal control of expressed proteins]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 130: 1505-11. PMID 21048410 DOI: 10.1248/Yakushi.130.1505 |
0.326 |
|
| 2010 |
Matsuoka N, Nishikawa M, Mohri K, Rattanakiat S, Takakura Y. Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides. Journal of Controlled Release : Official Journal of the Controlled Release Society. 148: 311-6. PMID 20887761 DOI: 10.1016/J.Jconrel.2010.09.019 |
0.308 |
|
| 2010 |
Nishikawa M, Rattanakiat S, Takakura Y. DNA-based nano-sized systems for pharmaceutical and biomedical applications. Advanced Drug Delivery Reviews. 62: 626-32. PMID 20230867 DOI: 10.1016/J.Addr.2010.03.006 |
0.318 |
|
| 2010 |
Hattori K, Nishikawa M, Watcharanurak K, Ikoma A, Kabashima K, Toyota H, Takahashi Y, Takahashi R, Watanabe Y, Takakura Y. Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization. Journal of Immunology (Baltimore, Md. : 1950). 184: 2729-35. PMID 20107184 DOI: 10.4049/Jimmunol.0900215 |
0.322 |
|
| 2010 |
Guan X, Nishikawa M, Takemoto S, Ohno Y, Yata T, Takakura Y. Injection site-dependent induction of immune response by DNA vaccine: comparison of skin and spleen as a target for vaccination. The Journal of Gene Medicine. 12: 301-9. PMID 20084616 DOI: 10.1002/Jgm.1432 |
0.366 |
|
| 2010 |
Yasuda S, Yoshida H, Nishikawa M, Takakura Y. Comparison of the type of liposome involving cytokine production induced by non-CpG Lipoplex in macrophages. Molecular Pharmaceutics. 7: 533-42. PMID 20047296 DOI: 10.1021/Mp900247D |
0.36 |
|
| 2010 |
Mizuno Y, Naoi T, Nishikawa M, Rattanakiat S, Hamaguchi N, Hashida M, Takakura Y. Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice. Journal of Controlled Release : Official Journal of the Controlled Release Society. 141: 252-9. PMID 19778560 DOI: 10.1016/J.Jconrel.2009.09.014 |
0.375 |
|
| 2010 |
Nishikawa M, Otsuki T, Ota A, Guan X, Takemoto S, Takahashi Y, Takakura Y. Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 421-8. PMID 19724264 DOI: 10.1038/Mt.2009.203 |
0.339 |
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| 2009 |
Yata T, Nishikawa M, Nishizaki C, Oku M, Yurimoto H, Sakai Y, Takakura Y. Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase. Free Radical Biology & Medicine. 47: 1772-8. PMID 19804819 DOI: 10.1016/J.Freeradbiomed.2009.09.027 |
0.303 |
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| 2009 |
Rattanakiat S, Nishikawa M, Funabashi H, Luo D, Takakura Y. The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity. Biomaterials. 30: 5701-6. PMID 19604576 DOI: 10.1016/J.Biomaterials.2009.06.053 |
0.325 |
|
| 2009 |
Yoshida H, Nishikawa M, Yasuda S, Mizuno Y, Toyota H, Kiyota T, Takahashi R, Takakura Y. TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice. The Journal of Gene Medicine. 11: 708-17. PMID 19462411 DOI: 10.1002/Jgm.1348 |
0.339 |
|
| 2009 |
Takahashi Y, Nishikawa M, Takakura Y. Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy. Advanced Drug Delivery Reviews. 61: 760-6. PMID 19386274 DOI: 10.1016/J.Addr.2009.04.006 |
0.301 |
|
| 2009 |
Nishikawa M, Hashida M, Takakura Y. Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis. Advanced Drug Delivery Reviews. 61: 319-26. PMID 19385054 DOI: 10.1016/J.Addr.2009.01.001 |
0.325 |
|
| 2009 |
Isaji K, Kawase A, Matono M, Guan X, Nishikawa M, Takakura Y. Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination. Journal of Controlled Release : Official Journal of the Controlled Release Society. 135: 227-33. PMID 19331843 DOI: 10.1016/J.Jconrel.2009.01.026 |
0.347 |
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| 2009 |
Mitsui M, Nishikawa M, Zang L, Ando M, Hattori K, Takahashi Y, Watanabe Y, Takakura Y. Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression. The Journal of Gene Medicine. 11: 435-43. PMID 19291673 DOI: 10.1002/Jgm.1317 |
0.343 |
|
| 2009 |
Takemoto S, Nishikawa M, Otsuki T, Yamaoka A, Maeda K, Ota A, Takakura Y. Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation. Journal of Controlled Release : Official Journal of the Controlled Release Society. 135: 11-8. PMID 19100299 DOI: 10.1016/J.Jconrel.2008.11.024 |
0.312 |
|
| 2008 |
Takahashi Y, Kaneda H, Takasuka N, Hattori K, Nishikawa M, Watanabe Y, Takakura Y. Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells. Cancer Science. 99: 1650-5. PMID 18754879 DOI: 10.1111/J.1349-7006.2008.00850.X |
0.338 |
|
| 2008 |
Takahashi Y, Nishikawa M, Suehara T, Takiguchi N, Takakura Y. Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice. International Journal of Cancer. 123: 2315-20. PMID 18729199 DOI: 10.1002/Ijc.23812 |
0.314 |
|
| 2008 |
Nishikawa M, Nakayama A, Takahashi Y, Fukuhara Y, Takakura Y. Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution. Human Gene Therapy. 19: 1009-1020. PMID 18694297 DOI: 10.1089/Hum.2008.020 |
0.367 |
|
| 2008 |
Ogawa Y, Yoshinaga T, Nishikawa M, Takakura Y. Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F1 mice. Biological & Pharmaceutical Bulletin. 31: 1244-1249. PMID 18520062 DOI: 10.1248/Bpb.31.1244 |
0.334 |
|
| 2008 |
Takahashi Y, Nishikawa M, Takakura Y. Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes Gene Therapy. 15: 572-582. PMID 18273056 DOI: 10.1038/Sj.Gt.3303103 |
0.328 |
|
| 2008 |
Yoshida H, Nishikawa M, Yasuda S, Mizuno Y, Takakura Y. Cellular Activation by Plasmid DNA in Various Macrophages in Primary Culture Journal of Pharmaceutical Sciences. 97: 4575-4585. PMID 18228575 DOI: 10.1002/Jps.21302 |
0.341 |
|
| 2008 |
Nishikawa M, Matono M, Rattanakiat S, Matsuoka N, Takakura Y. Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation. Immunology. 124: 247-255. PMID 18217956 DOI: 10.1111/J.1365-2567.2007.02762.X |
0.336 |
|
| 2008 |
Kako K, Nishikawa M, Yoshida H, Takakura Y. Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice Journal of Pharmaceutical Sciences. 97: 3074-3083. PMID 18064709 DOI: 10.1002/Jps.21254 |
0.324 |
|
| 2008 |
Nishikawa M, Takemoto S, Takakura Y. Heat shock protein derivatives for delivery of antigens to antigen presenting cells International Journal of Pharmaceutics. 354: 23-27. PMID 17980980 DOI: 10.1016/J.Ijpharm.2007.09.030 |
0.317 |
|
| 2007 |
Takahashi Y, Nishikawa M, Takakura Y. In vivo siRNA delivery to tumor cells and its application to cancer gene therapy Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan. 127: 1525-1531. PMID 17917414 DOI: 10.1248/Yakushi.127.1525 |
0.355 |
|
| 2007 |
Hirata K, Nishikawa M, Kobayashi N, Takahashi Y, Takakura Y. Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. Journal of Pharmaceutical Sciences. 96: 2251-2261. PMID 17387694 DOI: 10.1002/Jps.20879 |
0.373 |
|
| 2007 |
Kawano H, Nishikawa M, Mitsui M, Takahashi Y, Kako K, Yamaoka K, Watanabe Y, Takakura Y. Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA International Journal of Cancer. 121: 401-406. PMID 17372909 DOI: 10.1002/Ijc.22636 |
0.359 |
|
| 2007 |
Nishikawa M, Takemoto S, Takakura Y. Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan. 127: 293-300. PMID 17268149 DOI: 10.1248/Yakushi.127.293 |
0.318 |
|
| 2007 |
Fukuhara Y, Naoi T, Ogawa Y, Nishikawa M, Takakura Y. Plasmid DNA Uptake and Subsequent Cellular Activation Characteristics in Human Monocyte-Derived Cells in Primary Culture Journal of Pharmaceutical Sciences. 96: 1576-1584. PMID 17238196 DOI: 10.1002/Jps.20816 |
0.358 |
|
| 2007 |
Yoshinaga T, Yasuda K, Ogawa Y, Nishikawa M, Takakura Y. DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells. Immunology. 120: 295-302. PMID 17199803 DOI: 10.1111/J.1365-2567.2006.02451.X |
0.345 |
|
| 2007 |
Nagayama S, Ogawara K, Minato K, Fukuoka Y, Takakura Y, Hashida M, Higaki K, Kimura T. Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor. International Journal of Pharmaceutics. 329: 192-8. PMID 17005341 DOI: 10.1016/J.Ijpharm.2006.08.025 |
0.321 |
|
| 2007 |
Yamasaki Y, Ikenaga T, Otsuki T, Nishikawa M, Takakura Y. Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery. Vaccine. 25: 85-91. PMID 16956699 DOI: 10.1016/J.Vaccine.2006.07.017 |
0.322 |
|
| 2006 |
Takahashi Y, Nishikawa M, Takakura Y. Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting β-catenin or hypoxia-inducible factor 1α Journal of Controlled Release. 116: 90-95. PMID 17056147 DOI: 10.1016/J.Jconrel.2006.09.002 |
0.339 |
|
| 2006 |
Yasuda K, Wagner H, Takakura Y. Role of immunostimulatory DNA and TLR9 in gene therapy. Critical Reviews in Therapeutic Drug Carrier Systems. 23: 89-110. PMID 16952273 DOI: 10.1615/Critrevtherdrugcarriersyst.V23.I2.10 |
0.312 |
|
| 2006 |
Kawase A, Isaji K, Yamaoka A, Kobayashi N, Nishikawa M, Takakura Y. Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice Vaccine. 24: 5535-5545. PMID 16716462 DOI: 10.1016/J.Vaccine.2006.04.056 |
0.338 |
|
| 2006 |
Takahashi Y, Kaneda H, Nishikawa M, Takakura Y. 616. Enhancement of Antitumor Activity of Interferons by RNAi-Mediated Silencing of SOCS Genes in Tumor Cells Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.691 |
0.352 |
|
| 2006 |
Otsuki T, Nishikawa M, Ota A, Takemoto S, Takakura Y. 989. Induction of Antitumor Immunity by Cell- Penetrating Peptide-Coupled Hsp70 Gene Transfer to Tumor Cells Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.1082 |
0.377 |
|
| 2006 |
Nishikawa M, Hirata K, Machida K, Takahashi Y, Yuasa K, Takeda S, Takakura Y. 40. Increased Transgene Expression of Dystrophin in mdx Muscle by RNAi-Mediated Silencing of Calpain Expression Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.053 |
0.317 |
|
| 2005 |
Nishikawa M, Hyoudou K, Kobayashi Y, Umeyama Y, Takakura Y, Hashida M. Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes. Journal of Controlled Release. 109: 101-107. PMID 16256238 DOI: 10.1016/J.Jconrel.2005.09.017 |
0.345 |
|
| 2005 |
Nishikawa M, Takakura Y, Hashida M. Pharmacokinetics of plasmid DNA-based non-viral gene medicine. Advances in Genetics. 53: 47-68. PMID 16243060 DOI: 10.1016/S0065-2660(05)53003-7 |
0.366 |
|
| 2005 |
Yamane I, Nishikawa M, Takakura Y. Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages. International Journal of Pharmaceutics. 305: 145-153. PMID 16219432 DOI: 10.1016/J.Ijpharm.2005.08.020 |
0.361 |
|
| 2005 |
Matsui Y, Kobayashi N, Nishikawa M, Takakura Y. Sequence-Specific Suppression of mdr1a/1b Expression in Mice via RNA Interference Pharmaceutical Research. 22: 2091-2098. PMID 16184445 DOI: 10.1007/S11095-005-8178-8 |
0.351 |
|
| 2005 |
Ogawa Y, Yoshinaga T, Yasuda K, Nishikawa M, Takakura Y. The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F1 mice Immunology Letters. 101: 32-40. PMID 15979158 DOI: 10.1016/J.Imlet.2005.05.003 |
0.343 |
|
| 2005 |
Takahashi Y, Nishikawa M, Kobayashi N, Takakura Y. Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: Quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases Journal of Controlled Release. 105: 332-343. PMID 15936841 DOI: 10.1016/J.Jconrel.2005.04.012 |
0.336 |
|
| 2005 |
Kawase A, Kobayashi N, Isaji K, Nishikawa M, Takakura Y. Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule. International Journal of Pharmaceutics. 293: 291-301. PMID 15778067 DOI: 10.1016/J.Ijpharm.2004.12.011 |
0.361 |
|
| 2005 |
Kobayashi N, Nishikawa M, Takakura Y. The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels. Advanced Drug Delivery Reviews. 57: 713-731. PMID 15757757 DOI: 10.1016/J.Addr.2004.12.006 |
0.336 |
|
| 2005 |
Nishikawa M, Takakura Y, Hashida M. Theoretical considerations involving the pharmacokinetics of plasmid DNA. Advanced Drug Delivery Reviews. 57: 675-688. PMID 15757754 DOI: 10.1016/J.Addr.2004.12.003 |
0.355 |
|
| 2005 |
Yasuda K, Ogawa Y, Yamane I, Nishikawa M, Takakura Y. Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways. Journal of Leukocyte Biology. 77: 71-79. PMID 15496451 DOI: 10.1189/Jlb.0204089 |
0.337 |
|
| 2005 |
Kawano H, Nishikawa M, Mitsui M, Takakura Y. 701. Enhanced Anti-Tumor Effect of Interferon Gene Transfer by Sustained Transgene Expression Using CpG-Reduced Plasmid DNA Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.241 |
0.354 |
|
| 2005 |
Takahashi Y, Nishikawa M, Takakura Y. 71. Intratumoral Delivery of Small Interfering RNA for Inhibition of Tumor Progression in Mice Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.049 |
0.349 |
|
| 2004 |
Nishikawa M, Tamada A, Hyoudou K, Umeyama Y, Takahashi Y, Kobayashi Y, Kumai H, Ishida E, Staud F, Yabe Y, Takakura Y, Yamashita F, Hashida M. Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice. Clinical & Experimental Metastasis. 21: 213-21. PMID 15387371 DOI: 10.1023/B:Clin.0000037706.13747.5E |
0.346 |
|
| 2004 |
Nakamura M, Yamaguchi S, Watanabe Y, Yamashita F, Takakura Y, Hashida M. Exogenous Expression of Interferon-β in Cultured Brain Microvessel Endothelial Cells Biological & Pharmaceutical Bulletin. 27: 1441-1443. PMID 15340234 DOI: 10.1248/Bpb.27.1441 |
0.337 |
|
| 2004 |
Hisazumi J, Kobayashi N, Nishikawa M, Takakura Y. Significant Role of Liver Sinusoidal Endothelial Cells in Hepatic Uptake and Degradation of Naked Plasmid DNA After Intravenous Injection Pharmaceutical Research. 21: 1223-1228. PMID 15290863 DOI: 10.1023/B:Pham.0000033009.17594.E5 |
0.353 |
|
| 2004 |
Ikenaga T, Yamasaki Y, Shakushiro K, Nishikawa M, Takakura Y. Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen Vaccine. 22: 2609-2616. PMID 15193386 DOI: 10.1016/J.Vaccine.2003.12.023 |
0.322 |
|
| 2004 |
Kobayashi N, Nishikawa M, Hirata K, Takakura Y. Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: implication of a nonspecific process in efficient intracellular gene delivery. Journal of Gene Medicine. 6: 584-592. PMID 15133769 DOI: 10.1002/Jgm.541 |
0.352 |
|
| 2004 |
Kobayashi N, Hirata K, Chen S, Kawase A, Nishikawa M, Takakura Y. Hepatic delivery of particulates in the submicron range by a hydrodynamics‐based procedure: implications for particulate gene delivery systems Journal of Gene Medicine. 6: 455-463. PMID 15079820 DOI: 10.1002/Jgm.531 |
0.315 |
|
| 2004 |
Yasuda K, Kawano H, Yamane I, Ogawa Y, Yoshinaga T, Nishikawa M, Takakura Y. Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA Immunology. 111: 282-290. PMID 15009428 DOI: 10.1111/J.1365-2567.2004.01814.X |
0.325 |
|
| 2004 |
Kobayashi N, Matsui Y, Kawase A, Hirata K, Miyagishi M, Taira K, Nishikawa M, Takakura Y. Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression. Journal of Pharmacology and Experimental Therapeutics. 308: 688-693. PMID 14610223 DOI: 10.1124/Jpet.103.059931 |
0.357 |
|
| 2004 |
Kawaguchi H, Matsui Y, Watanabe Y, Takakura Y. Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse Journal of Pharmacology and Experimental Therapeutics. 308: 91-96. PMID 14569074 DOI: 10.1124/Jpet.103.057521 |
0.32 |
|
| 2004 |
Sakurai F, Terada T, Maruyama M, Watanabe Y, Yamashita F, Takakura Y, Hashida M. Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model. Cancer Gene Therapy. 10: 661-8. PMID 12944985 DOI: 10.1038/Sj.Cgt.7700617 |
0.319 |
|
| 2003 |
Nishikawa M, Nakano T, Okabe T, Hamaguchi N, Yamasaki Y, Takakura Y, Yamashita F, Hashida M. Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study. Bioconjugate Chemistry. 14: 955-961. PMID 13129398 DOI: 10.1021/Bc034032Y |
0.305 |
|
| 2003 |
Kawase A, Nomura T, Yasuda K, Kobayashi N, Hashida M, Takakura Y. Disposition and Gene Expression Characteristics in Solid Tumors and Skeletal Muscle after Direct Injection of Naked Plasmid DNA in Mice Journal of Pharmaceutical Sciences. 92: 1295-1304. PMID 12761818 DOI: 10.1002/Jps.10392 |
0.344 |
|
| 2003 |
Yamasaki Y, Hisazumi J, Yamaoka K, Takakura Y. Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules. European Journal of Pharmaceutical Sciences. 18: 305-312. PMID 12694882 DOI: 10.1016/S0928-0987(03)00021-6 |
0.32 |
|
| 2002 |
Takagi A, Yabe Y, Oka Y, Takakura Y, Hashida M. Effect of co-administration of cationic macromolecules on the in vivo disposition and in situ renal disposition characteristics of rhIL-11. Drug Metabolism and Pharmacokinetics. 17: 136-141. PMID 15618662 DOI: 10.2133/Dmpk.17.136 |
0.308 |
|
| 2002 |
Kobayashi N, Kuramoto T, Chen S, Watanabe Y, Takakura Y. Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models. Molecular Therapy. 6: 737-744. PMID 12498770 DOI: 10.1006/Mthe.2002.0803 |
0.365 |
|
| 2002 |
Yoshinaga T, Yasuda K, Ogawa Y, Takakura Y. Efficient uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism. Biochemical and Biophysical Research Communications. 299: 389-394. PMID 12445812 DOI: 10.1016/S0006-291X(02)02648-7 |
0.352 |
|
| 2002 |
Takakura Y, Nishikawa M, Yamashita F, Hashida M. Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery. Journal of Drug Targeting. 10: 99-104. PMID 12074546 DOI: 10.1080/10611860290016694 |
0.365 |
|
| 2002 |
Yasuda K, Ogawa Y, Kishimoto M, Takagi T, Hashida M, Takakura Y. Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes. Biochemical and Biophysical Research Communications. 293: 344-348. PMID 12054606 DOI: 10.1016/S0006-291X(02)00210-3 |
0.34 |
|
| 2002 |
Nakanishi K, Watanabe Y, Maruyama M, Yamashita F, Takakura Y, Hashida M. Secretion polarity of interferon-beta in epithelial cell lines. Archives of Biochemistry and Biophysics. 402: 201-7. PMID 12051664 DOI: 10.1016/S0003-9861(02)00093-0 |
0.301 |
|
| 2002 |
Yamasaki Y, Sumimoto K, Nishikawa M, Yamashita F, Yamaoka K, Hashida M, Takakura Y. Pharmacokinetic Analysis of in Vivo Disposition of Succinylated Proteins Targeted to Liver Nonparenchymal Cells via Scavenger Receptors: Importance of Molecular Size and Negative Charge Density for in Vivo Recognition by Receptors Journal of Pharmacology and Experimental Therapeutics. 301: 467-477. PMID 11961045 DOI: 10.1124/Jpet.301.2.467 |
0.365 |
|
| 2001 |
Opanasopit P, Nishikawa M, Yamashita F, Takakura Y, Hashida M. Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin : A possible carrier for Kupffer cells Journal of Drug Targeting. 9: 341-351. PMID 11770704 DOI: 10.3109/10611860108998770 |
0.376 |
|
| 2001 |
Akamatsu K, Yamasaki Y, Nishikawa M, Takakura Y, Hashida M. Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E1 using lactosylated poly(l-glutamic hydrazide) as a carrier Biochemical Pharmacology. 62: 1531-1536. PMID 11728389 DOI: 10.1016/S0006-2952(01)00799-7 |
0.333 |
|
| 2001 |
Hashida M, Nishikawa M, Yamashita F, Takakura Y. Cell-specific delivery of genes with glycosylated carriers. Advanced Drug Delivery Reviews. 52: 187-196. PMID 11718943 DOI: 10.1016/S0169-409X(01)00209-5 |
0.389 |
|
| 2001 |
Sakurai F, Nishioka T, Saito H, Baba T, Okuda A, Matsumoto O, Taga T, Yamashita F, Takakura Y, Hashida M. Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid Gene Therapy. 8: 677-686. PMID 11406762 DOI: 10.1038/Sj.Gt.3301460 |
0.34 |
|
| 2001 |
Takakura Y, Nishikawa M, Yamashita F, Hashida M. Development of gene drug delivery systems based on pharmacokinetic studies European Journal of Pharmaceutical Sciences. 13: 71-76. PMID 11292570 DOI: 10.1016/S0928-0987(00)00209-8 |
0.362 |
|
| 2000 |
Nishikawa M, Yamauchi M, Morimoto K, Ishida E, Takakura Y, Hashida M. Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system Gene Therapy. 7: 548-555. PMID 10819569 DOI: 10.1038/Sj.Gt.3301140 |
0.399 |
|
| 2000 |
Nishikawa M, Takemura S, Yamashita F, Takakura Y, Meijer DK, Hashida M, Swart PJ. Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice. Journal of Drug Targeting. 8: 29-38. PMID 10761643 DOI: 10.3109/10611860009009207 |
0.385 |
|
| 2000 |
Sakurai F, Inoue R, Nishino Y, Okuda A, Matsumoto O, Taga T, Yamashita F, Takakura Y, Hashida M. Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression Journal of Controlled Release. 66: 255-269. PMID 10742585 DOI: 10.1016/S0168-3659(99)00280-1 |
0.384 |
|
| 2000 |
Sakurai F, Yamashita F, Takakura Y, Hashida M. Relationship Between Physicochemical Characterisitcs, Distribution Of Dna-Cationic Liposome Complexes And Their Gene Expression, And Application To Gene Therapy Drug Metabolism and Pharmacokinetics. 15: 112-113. DOI: 10.2133/Dmpk.15.Supplement_112 |
0.362 |
|
| 2000 |
Sakurai F, Inoue R, Nishino Y, Okuda A, Matsumoto O, Taga T, Yamashita F, Takakura Y, Hashida M. Erratum to “Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression”: [Journal of Controlled Release 66 (2000) 255–269]☆ Journal of Controlled Release. 69: 219-220. DOI: 10.1016/S0168-3659(00)00324-2 |
0.338 |
|
| 1999 |
Takagi T, Hashiguchi M, Hiramatsu T, Yamashita F, Takakura Y, Hashida M. Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages. Journal of Drug Targeting. 7: 363-371. PMID 10721798 DOI: 10.3109/10611869909085519 |
0.301 |
|
| 1999 |
Hashida M, Akamatsu K, Nishikawa M, Yamashita F, Takakura Y. Design of polymeric prodrugs of prostaglandin E1 having galactose residue for hepatocyte targeting Journal of Controlled Release. 62: 253-262. PMID 10518658 DOI: 10.1016/S0168-3659(99)00045-0 |
0.365 |
|
| 1999 |
Staud F, Nishikawa M, Morimoto K, Takakura Y, Hashida M. Disposition of radioactivity after injection of liver‐targeted proteins labeled with 111In or 125I. Effect of labeling on distribution and excretion of radioactivity in rats Journal of Pharmaceutical Sciences. 88: 577-585. PMID 10350492 DOI: 10.1021/Js9804415 |
0.333 |
|
| 1999 |
Ogawara KI, Hasegawa S, Nishikawa M, Takakura Y, Hashida M. Pharmacokinetic Evaluation of Mannosylated Bovine Serum Albumin as a Liver Cell-Specific Carrier: Quantitative Comparison with Other Hepatotropic Ligands Journal of Drug Targeting. 6: 349-360. PMID 10342383 DOI: 10.3109/10611869908996842 |
0.332 |
|
| 1999 |
Nomura T, Yasuda K, Yamada T, Okamoto S, Mahato RI, Watanabe Y, Takakura Y, Hashida M. Gene expression and antitumor effects following direct interferon (IFN)-gamma gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice. Gene Therapy. 6: 121-9. PMID 10341884 DOI: 10.1038/Sj.Gt.3300792 |
0.356 |
|
| 1999 |
Yabe Y, Koyama Y, Nishikawa M, Takakura Y, Hashida M. Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice. Free Radical Research. 30: 265-274. PMID 10230805 DOI: 10.1080/10715769900300291 |
0.322 |
|
| 1999 |
Takakura Y, Takagi T, Hashiguchi M, Nishikawa M, Yamashita F, Doi T, Imanishi T, Suzuki H, Kodama T, Hashida M. Characterization of Plasmid DNA Binding and Uptake by Peritoneal Macrophages from Class A Scavenger Receptor Knockout Mice Pharmaceutical Research. 16: 503-508. PMID 10227703 DOI: 10.1023/A:1018842210588 |
0.339 |
|
| 1999 |
Staud F, Nishikawa M, Takakura Y, Hashida M. Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation. Biochimica Et Biophysica Acta. 1427: 183-192. PMID 10216235 DOI: 10.1016/S0304-4165(99)00031-8 |
0.312 |
|
| 1999 |
Yura H, Yoshimura N, Hamashima T, Akamatsu K, Nishikawa M, Takakura Y, Hashida M. Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate Journal of Controlled Release. 57: 87-99. PMID 10084872 DOI: 10.1016/S0168-3659(98)00150-3 |
0.33 |
|
| 1999 |
Nishikawa M, Staud F, Takemura S, Takakura Y, Hashida M. Pharmacokinetic Evaluation of Biodistribution Data Obtained with Radiolabeled Proteins in Mice Biological & Pharmaceutical Bulletin. 22: 214-218. PMID 10077446 DOI: 10.1248/Bpb.22.214 |
0.348 |
|
| 1999 |
Masuda H, Takakura Y, Hashida M. Pharmacokinetics And Disposition Characteristics Of Recombinant Decorin After Intravenous Injection Into Mice Biochimica Et Biophysica Acta. 1426: 420-428. PMID 10076058 DOI: 10.1016/S0304-4165(98)00163-9 |
0.347 |
|
| 1998 |
Takakura Y, Mahato RI, Hashida M. Extravasation of macromolecules Advanced Drug Delivery Reviews. 34: 93-108. PMID 10837672 DOI: 10.1016/S0169-409X(98)00006-4 |
0.351 |
|
| 1998 |
Akamatsu K, Imai M, Yamasaki Y, Nishikawa M, Takakura Y, Hashida M. Disposition Characteristics of Glycosylated Poly(amino acids) as Liver Cell-Specific Drug Carrier Journal of Drug Targeting. 6: 229-239. PMID 9888309 DOI: 10.3109/10611869808997897 |
0.347 |
|
| 1998 |
Takagi A, Yabe Y, Yoshida M, Takakura Y, Hashida M. Hepatic Disposition Characteristics of Recombinant Human Interleukin-11 (rhIL-11) in the Perfused Rat Liver Biological & Pharmaceutical Bulletin. 21: 1364-1366. PMID 9881656 DOI: 10.1248/Bpb.21.1364 |
0.32 |
|
| 1998 |
Kawakami S, Yamashita F, Nishikawa M, Takakura Y, Hashida M. Asialoglycoprotein Receptor-Mediated Gene Transfer Using Novel Galactosylated Cationic Liposomes Biochemical and Biophysical Research Communications. 252: 78-83. PMID 9813149 DOI: 10.1006/Bbrc.1998.9602 |
0.357 |
|
| 1998 |
Okamoto S, Watanabe Y, Takakura Y, Hashida M. Cationic Liposome-Mediated Efficient Induction of Type I Interferons by a Low Dose of Poly I:Poly C in Mouse Cell Lines. Journal of Biochemistry. 124: 697-701. PMID 9756612 DOI: 10.1093/Oxfordjournals.Jbchem.A022168 |
0.31 |
|
| 1998 |
Nomura T, Saikawa A, Morita S, Sakaeda T, Yamashita F, Honda K, Takakura Y, Hashida M. Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection Journal of Controlled Release. 52: 239-252. PMID 9743445 DOI: 10.1016/S0168-3659(97)00185-5 |
0.323 |
|
| 1998 |
Hashida M, Takemura S, Nishikawa M, Takakura Y. Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine). Journal of Controlled Release. 53: 301-310. PMID 9741938 DOI: 10.1016/S0168-3659(97)00263-0 |
0.408 |
|
| 1998 |
Kanamaru T, Takagi T, Takakura Y, Hashida M. Biological Effects and Cellular Uptake of c-myc Antisense Oligonucleotides and Their Cationic Liposome Complexes Journal of Drug Targeting. 5: 235-245. PMID 9713974 DOI: 10.3109/10611869808995878 |
0.318 |
|
| 1998 |
Ogawara KI, Nishikawa M, Takakura Y, Hashida M. Pharmacokinetic Analysis of Hepatic Uptake of Galactosylated Bovine Serum Albumin in a Perfused Rat Liver Journal of Controlled Release. 50: 309-317. PMID 9685898 DOI: 10.1016/S0168-3659(97)00157-0 |
0.306 |
|
| 1998 |
Takino T, Koreeda N, Nomura T, Sakaeda T, Yamashita F, Takakura Y, Hashida M. Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems. Biological & Pharmaceutical Bulletin. 21: 492-497. PMID 9635506 DOI: 10.1248/Bpb.21.492 |
0.33 |
|
| 1998 |
Takagi T, Hashiguchi M, Mahato RI, Tokuda H, Takakura Y, Hashida M. Involvement of Specific Mechanism in Plasmid DNA Uptake by Mouse Peritoneal Macrophages Biochemical and Biophysical Research Communications. 245: 729-733. PMID 9588183 DOI: 10.1006/Bbrc.1998.8521 |
0.34 |
|
| 1998 |
Nakamura M, Davila-Zavala P, Tokuda H, Takakura Y, Hashida M. Uptake and Gene Expression of Naked Plasmid DNA in Cultured Brain Microvessel Endothelial Cells Biochemical and Biophysical Research Communications. 245: 235-239. PMID 9535815 DOI: 10.1006/Bbrc.1998.8334 |
0.357 |
|
| 1998 |
Ogawara K, Yoshida M, Kubo J, Takakura Y, Hashida M, Higaki K, Kimura T. Size-Dependent Hepatic Disposition Of Polystyrene Microspheres Drug Metabolism and Pharmacokinetics. 13: 112-113. DOI: 10.2133/Dmpk.13.Supplement_112 |
0.316 |
|
| 1997 |
Mahato RI, Takakura Y, Hashida M. Development of targeted delivery systems for nucleic acid drugs. Journal of Drug Targeting. 4: 337-57. PMID 9239575 DOI: 10.3109/10611869709017892 |
0.334 |
|
| 1997 |
Kawabata K, Kondo M, Watanabe Y, Takakura Y, Hashida M. Non-Polarized Secretion of Mouse Interferon-β from Gene-Transferred Human Intestinal Caco-2 Cells Pharmaceutical Research. 14: 483-485. PMID 9144735 DOI: 10.1023/A:1012151616910 |
0.3 |
|
| 1997 |
Mahato RI, Takemura S, Akamatsu K, Nishikawa M, Takakura Y, Hashida M. Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine). Biochemical Pharmacology. 53: 887-95. PMID 9113108 DOI: 10.1016/S0006-2952(96)00880-5 |
0.334 |
|
| 1997 |
Kawabata K, Okamoto S, Takakura Y, Hashida M, Hashimura T, Watanabe Y. A physiological role of interferon (IFN)-β derived from tumor: tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-β Cancer Letters. 113: 159-164. PMID 9065816 DOI: 10.1016/S0304-3835(96)04594-6 |
0.319 |
|
| 1997 |
Takakura Y, Mahato RI, Yoshida M, Kanamaru T, Hashida M. Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system. Antisense & Nucleic Acid Drug Development. 6: 177-83. PMID 8915502 DOI: 10.1089/Oli.1.1996.6.177 |
0.314 |
|
| 1997 |
Jani PU, Nomura T, Yamashita F, Takakura Y, Florence AT, Hashida M. Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats. Journal of Drug Targeting. 4: 87-93. PMID 8894968 DOI: 10.3109/10611869609046266 |
0.446 |
|
| 1997 |
Mahato RI, Takakura Y, Hashida M. Nonviral Vectors for In Vivo Gene Delivery: Physicochemical and Pharmacokinetic Considerations Critical Reviews in Therapeutic Drug Carrier Systems. 14: 40. DOI: 10.1615/Critrevtherdrugcarriersyst.V14.I2.20 |
0.378 |
|
| 1997 |
Tokuda H, Nagano H, Takakura Y, Hashida M. Uptake Characteristics of Anionized and Cationized Proteins in Brain Microvessel Endothelial Cells Pharmacy and Pharmacology Communications. 3: 147-151. DOI: 10.1111/J.2042-7158.1997.Tb00240.X |
0.316 |
|
| 1997 |
Furitsu H, Ogawara KI, Fujita T, Yamashita F, Takakura Y, Sezaki H, Hashida M. Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver International Journal of Pharmaceutics. 151: 15-26. DOI: 10.1016/S0378-5173(97)04899-0 |
0.342 |
|
| 1997 |
Akamatsu K, Nishikawa M, Takakura Y, Hashida M. Synthesis and biodistribution study of liver-specific prostaglandin E1 polymeric conjugate International Journal of Pharmaceutics. 155: 65-74. DOI: 10.1016/S0378-5173(97)00159-2 |
0.344 |
|
| 1997 |
Hashida M, Hirabayashi H, Nishikawa M, Takakura Y. Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis Journal of Controlled Release. 46: 129-137. DOI: 10.1016/S0168-3659(96)01577-5 |
0.343 |
|
| 1996 |
Takakura Y. Development of drug delivery systems for macromolecular drugs Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan. 116: 519-532. PMID 8831257 DOI: 10.1248/Yakushi1947.116.7_519 |
0.342 |
|
| 1996 |
Hirabayashi H, Nishikawa M, Takakura Y, Hashida M. Development and Pharmacokinetics of Galactosylated Poly-L-Glutamic Acid as a Biodegradable Carrier for Liver-Specific Drug Delivery Pharmaceutical Research. 13: 880-884. PMID 8792426 DOI: 10.1023/A:1016053128569 |
0.319 |
|
| 1996 |
Takakura Y, Hashida M. Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution. Pharmaceutical Research. 13: 820-831. PMID 8792417 DOI: 10.1023/A:1016084508097 |
0.324 |
|
| 1996 |
Yoshida M, Mahato RI, Kawabata K, Takakura Y, Hashida M. Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system. Pharmaceutical Research. 13: 599-603. PMID 8710753 DOI: 10.1023/A:1016058407671 |
0.346 |
|
| 1996 |
Mahato RI, Kawabata K, Nomura T, Takakura Y, Hashida M. Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes. Journal of Pharmaceutical Sciences. 84: 1267-71. PMID 8587040 DOI: 10.1002/Jps.2600841102 |
0.379 |
|
| 1996 |
Mahato RI, Kawabata K, Takakura Y, Hashida M. In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes. Journal of Drug Targeting. 3: 149-57. PMID 7496728 DOI: 10.3109/10611869509059214 |
0.37 |
|
| 1996 |
Takakura Y. Pharmacokinetic Analysis and Development of Delivery Systems of Macromolecular Drugs Drug Metabolism and Pharmacokinetics. 11: 436-442. DOI: 10.2133/Dmpk.11.436 |
0.334 |
|
| 1996 |
Nishikawa M, Takakura Y, Hashida M. Pharmacokinetic evaluation of polymeric carriers Advanced Drug Delivery Reviews. 21: 135-155. DOI: 10.1016/S0169-409X(96)00403-6 |
0.332 |
|
| 1996 |
Takakura Y, Mahato RI, Nishikawa M, Hashida M. Control of pharmacokinetic profiles of drug—macromolecule conjugates Advanced Drug Delivery Reviews. 19: 377-399. DOI: 10.1016/0169-409X(96)00010-5 |
0.348 |
|
| 1996 |
Hashida M, Mahato RI, Kawabata K, Miyao T, Nishikawa M, Takakura Y. Pharmacokinetics and targeted delivery of proteins and genes Journal of Controlled Release. 41: 91-97. DOI: 10.1016/0168-3659(96)01360-0 |
0.38 |
|
| 1995 |
Nishikawa M, Hirabayashi H, Takakura Y, Hashida M. Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: effect of molecular weight of proteins on targeting efficiency. Pharmaceutical Research. 12: 209-214. PMID 7784335 DOI: 10.1023/A:1016222808484 |
0.341 |
|
| 1995 |
Nishikawa M, Miyazaki C, Yamashita F, Takakura Y, Hashida M. Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties American Journal of Physiology-Gastrointestinal and Liver Physiology. 268. PMID 7762669 DOI: 10.1152/Ajpgi.1995.268.5.G849 |
0.32 |
|
| 1995 |
Kawabata K, Takakura Y, Hashida M. The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake. Pharmaceutical Research. 12: 825-830. PMID 7667185 DOI: 10.1023/A:1016248701505 |
0.374 |
|
| 1995 |
Takakura Y, Hashida M. Development of delivery systems of DNA medicines and possible obstacles to be overcome. Drug Delivery System. 10: 391-398. DOI: 10.2745/Dds.10.391 |
0.347 |
|
| 1995 |
Fujita T, Takakura Y, Sezaki H, Hashida M. Control of Disposition Characteristics of Proteins by Direct Cationization in Mice Pharmacy and Pharmacology Communications. 1: 371-375. DOI: 10.1111/J.2042-7158.1995.Tb00443.X |
0.345 |
|
| 1995 |
Hashida M, Nishikawa M, Takakura Y. Hepatic targeting of drugs and proteins by chemical modification Journal of Controlled Release. 36: 99-107. DOI: 10.1016/0168-3659(95)00050-I |
0.359 |
|
| 1995 |
Choksakulnimitr S, Masuda S, Tokuda H, Takakura Y, Hashida M. In vitro cytotoxicity of macromolecules in different cell culture systems Journal of Controlled Release. 34: 233-241. DOI: 10.1016/0168-3659(95)00007-U |
0.334 |
|
| 1994 |
Takakura Y, Masuda S, Tokuda H, Nishikawa M, Hashida M. Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism Biochemical Pharmacology. 47: 853-858. PMID 8135860 DOI: 10.1016/0006-2952(94)90485-5 |
0.311 |
|
| 1994 |
Fujita T, Nishikawa M, Ohtsubo Y, Ohno J, Takakura Y, Sezaki H, Hashida M. Control of in vivo fate of albumin derivatives utilizing combined chemical modification. Journal of Drug Targeting. 2: 157-165. PMID 8069594 DOI: 10.3109/10611869409015905 |
0.303 |
|
| 1994 |
Hashida M, Nishikawa M, Yamashita F, Takakura Y. Targeting Delivery of Protein Drugs by Chemical Modification Drug Development and Industrial Pharmacy. 20: 581-590. DOI: 10.3109/03639049409038320 |
0.367 |
|
| 1994 |
Nishikawa M, Hirabayashi H, Takakura Y, Hashida M. The effect of the molecular weight of glycosylated proteins on their targeting efficiency to the liver. Drug Delivery System. 9: 173-178. DOI: 10.2745/Dds.9.173 |
0.329 |
|
| 1994 |
Takino T, Yamashita F, Takakura Y, Hashida M. Hepatic Disposition Control Of Lipophilic Drugs Via Lipid Carrier Sysytems Drug Metabolism and Pharmacokinetics. 9: 122-125. DOI: 10.2133/Dmpk.9.Supplement_122 |
0.312 |
|
| 1994 |
Hashida M, Takakura Y. Pharmacokinetics in design of polymeric drug delivery systems Journal of Controlled Release. 31: 163-171. DOI: 10.1016/0168-3659(94)00025-5 |
0.317 |
|
| 1993 |
Takino T, Nakajima C, Takakura Y, Sezaki H, Hashida M. Controlled Biodistribution of Highly Lipophilic Drugs with Various Parenteral Formulations Journal of Drug Targeting. 1: 117-124. PMID 8069549 DOI: 10.3109/10611869308996067 |
0.322 |
|
| 1993 |
Nishikawa M, Kamijo A, Fujita T, Takakura Y, Sezaki H, Hashida M. Synthesis and Pharmacokinetics of a New Liver-Specific Carrier, Glycosylated Carboxymethyl-Dextran, and Its Application to Drug Targeting Pharmaceutical Research. 10: 1253-1261. PMID 7694271 DOI: 10.1023/A:1018949109004 |
0.38 |
|
| 1993 |
Nishikawa M, Takakura Y, Hashida M. Cell-Specific Targeting Of Drugs By Receptor-Mediated Endocytosis Based On Sugar Recognition Systems Drug Metabolism and Pharmacokinetics. 8: 723-726. DOI: 10.2133/Dmpk.8.Supplement_723 |
0.373 |
|
| 1992 |
Nishikawa M, Yamashita F, Takakura Y, Hashida M, Sezaki H. Demonstration of the receptor-mediated hepatic uptake of dextran in mice. Journal of Pharmacy and Pharmacology. 44: 396-401. PMID 1279155 DOI: 10.1111/J.2042-7158.1992.Tb03632.X |
0.339 |
|
| 1991 |
Nishida K, Eguchi Y, Takino T, Takakura Y, Hashida M, Sezaki H. Hepatic disposition characteristics of 111In-labeled lactosaminated bovine serum albumin in rats. Pharmaceutical Research. 8: 1253-1257. PMID 1796043 DOI: 10.1023/A:1015895511208 |
0.323 |
|
| 1991 |
Fujita T, Yasuda Y, Takakura Y, Hashida M, Sezaki H. Tissue Distribution of 111In-Labeled Uricase Conjugated with Charged Dextrans and Polyethylene Glycol Journal of Pharmacobio-Dynamics. 14: 623-629. PMID 1725532 DOI: 10.1248/Bpb1978.14.623 |
0.339 |
|
| 1991 |
Nishida K, Mihara K, Takino T, Nakane S, Takakura Y, Hashida M, Sezaki H. Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused Liver Pharmaceutical Research. 8: 437-444. PMID 1714579 DOI: 10.1023/A:1015886708598 |
0.325 |
|
| 1991 |
Noguchi A, Takahashi T, Yamaguchi T, Kitamura K, Takakura Y, Hashida M, Sezaki H. Tumor Localization and in vivo Antitumor Activity of the Immunoconjugate Composed of Anti-human Colon Cancer Monoclonal Antibody and Mitomycin C-Dextran Conjugate Japanese Journal of Cancer Research. 82: 219-226. PMID 1706329 DOI: 10.1111/J.1349-7006.1991.Tb01832.X |
0.313 |
|
| 1990 |
Hashida M, Atsumi R, Nishida K, Nakane S, Takakura Y, Sezaki H. Biliary excretion of mitomycin C dextran conjugates in relation to physicochemical characteristics of carrier dextran. Journal of Pharmacobio-Dynamics. 13: 441-447. PMID 1705289 DOI: 10.1248/Bpb1978.13.441 |
0.308 |
|
| 1990 |
Takakura Y, Fujita T, Hashida M, Sezaki H. Disposition characteristics of macromolecules in tumor-bearing mice. Pharmaceutical Research. 7: 339-346. PMID 1694582 DOI: 10.1023/A:1015807119753 |
0.333 |
|
| 1990 |
Imoto H, Ohkouchi K, Takakura Y, Hashida M, Sezaki H. Development of evaluation method for drug disposition in tumor using tissue-isolated tumor perfusion system. Drug Delivery System. 5: 77-81. DOI: 10.2745/Dds.5.77 |
0.304 |
|
| 1989 |
Takakura Y, Fujita T, Hashida M, Maeda H, Sezaki H. Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II: Biopharmaceutical and pharmacological properties. Journal of Pharmaceutical Sciences. 78: 219-222. PMID 2470896 DOI: 10.1002/Jps.2600780310 |
0.318 |
|
| 1989 |
Sato K, Itakura K, Nishida K, Takakura Y, Hashida M, Sezaki H. Disposition of a polymeric prodrug of mitomycin C, mitomycin C‐dextran conjugate, in the perfused rat liver Journal of Pharmaceutical Sciences. 78: 11-16. PMID 2468759 DOI: 10.1002/Jps.2600780105 |
0.3 |
|
| 1989 |
Takakura Y, Fujita T, Hashida M, Sezaki H. Comparison of polythylene glycol and dextran conjugation with protein drug. Drug Delivery System. 4: 123-124. DOI: 10.2745/Dds.4.123 |
0.328 |
|
| 1988 |
Nakane S, Matsumoto S, Takakura Y, Hashida M, Sezaki H. The Accumulation Mechanism of Cationic Mitomycin C‐dextran Conjugates in the Liver: In‐vivo Cellular Localization and In‐vitro Interaction with Hepatocytes Journal of Pharmacy and Pharmacology. 40: 1-6. PMID 2452868 DOI: 10.1111/J.2042-7158.1988.Tb05139.X |
0.323 |
|
| 1988 |
Takakura Y, Fujita T, Hashida M, Sezaki H. Strategy for tumor targeting by macromolecule-drug conjugates. Drug Delivery System. 3: 405-409. DOI: 10.2745/Dds.3.405 |
0.323 |
|
| 1987 |
Takakura Y, Takagi A, Hashida M, Sezaki H. Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice Pharmaceutical Research. 4: 293-300. PMID 2470072 DOI: 10.1023/A:1016489002393 |
0.333 |
|
| 1987 |
Takakura Y, Kitajima M, Matsumoto S, Hashida M, Sezaki H. Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities International Journal of Pharmaceutics. 37: 135-143. DOI: 10.1016/0378-5173(87)90018-4 |
0.349 |
|
| 1985 |
Matsumoto S, Arase Y, Takakura Y, Hashida M, Sezaki H. Plasma disposition and in vivo and in vitro antitumor activities of mitomycin C-dextran conjugate in relation to the mode of action. Chemical & Pharmaceutical Bulletin. 33: 2941-2947. PMID 2417734 DOI: 10.1248/Cpb.33.2941 |
0.312 |
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