Linda Griffith - Publications

Affiliations: 
Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Website:
https://be.mit.edu/directory/linda-g-griffith

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ahrens CC, Chiswick EL, Ravindra KC, Miller MA, Ramseier J, Isaacson KB, Lauffenburger DA, Griffith LG. Development and Application of the Metalloprotease Activity Multi-plexed Bead-based Immunoassay (MAMBI). Biochemistry. PMID 31474112 DOI: 10.1021/acs.biochem.9b00584  1
2019 Kassis T, Hernandez-Gordillo V, Langer R, Griffith LG. OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks. Scientific Reports. 9: 12479. PMID 31462669 DOI: 10.1038/s41598-019-48874-y  1
2019 Wang X, Cirit M, Wishnok JS, Griffith LG, Tannenbaum SR. Analysis of an Integrated Human Multi-organ Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics. Analytical Chemistry. PMID 31181164 DOI: 10.1021/acs.analchem.9b02224  0.4
2018 Kamm RD, Bashir R, Arora N, Dar RD, Gillette MU, Griffith LG, Kemp ML, Kinlaw K, Levin M, Martin AC, McDevitt TC, Nerem RM, Powers MJ, Saif TA, Sharpe J, et al. Perspective: The promise of multi-cellular engineered living systems. Apl Bioengineering. 2: 040901. PMID 31069321 DOI: 10.1063/1.5038337  1
2018 Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. Journal of Cancer. 9: 2559-2570. PMID 30026855 DOI: 10.7150/jca.24601  1
2018 Chan HF, Zhao R, Parada GA, Meng H, Leong KW, Griffith LG, Zhao X. Folding artificial mucosa with cell-laden hydrogels guided by mechanics models. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967135 DOI: 10.1073/pnas.1802361115  0.72
2018 Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR. Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis. The Journal of Biological Chemistry. PMID 29794029 DOI: 10.1074/jbc.M117.818542  0.4
2018 Maass C, Dallas M, LaBarge ME, Shockley M, Valdez J, Geishecker E, Stokes CL, Griffith LG, Cirit M. Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies. Scientific Reports. 8: 8015. PMID 29789564 DOI: 10.1038/s41598-018-25971-y  0.4
2018 Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, ... ... Griffith LG, et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Scientific Reports. 8: 4530. PMID 29540740 DOI: 10.1038/s41598-018-22749-0  1
2018 Clark AM, Kumar M, Wheeler S, Young C, Venkataramanan R, Stolz D, Griffith L, Lauffenburger DA, Wells A. A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures. Molecular & Cellular Proteomics : McP. PMID 29353230 DOI: 10.1074/mcp.RA117.000370  1
2017 Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A. Liver 'organ on a chip'. Experimental Cell Research. PMID 29291400 DOI: 10.1016/j.yexcr.2017.12.023  0.6
2017 Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL. Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates. Journal of Cancer. 8: 3916-3932. PMID 29187866 DOI: 10.7150/jca.20779  1
2017 Tsamandouras N, Chen WLK, Edington CD, Stokes CL, Griffith LG, Cirit M. Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies. The Aaps Journal. PMID 28752430 DOI: 10.1208/s12248-017-0122-4  0.4
2017 Chen WLK, Edington C, Suter E, Yu J, Velazquez JJ, Velazquez JG, Shockley M, Large EM, Venkataramanan R, Hughes DJ, Stokes CL, Trumper DL, Carrier RL, Cirit M, Griffith LG, et al. Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk. Biotechnology and Bioengineering. PMID 28667746 DOI: 10.1002/bit.26370  1
2017 Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR. Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a 3D human liver-immunocompetent co-culture system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28450578 DOI: 10.1124/dmd.116.074005  1
2017 Jørgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Fertility and Sterility. PMID 28433374 DOI: 10.1016/j.fertnstert.2017.03.013  1
2017 Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger D, White F, Griffith L. On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. Biomaterials. 130: 90-103. PMID 28371736 DOI: 10.1016/j.biomaterials.2017.03.030  0.32
2017 Cook CD, Hill AS, Guo M, Stockdale L, Papps JP, Isaacson KB, Lauffenburger DA, Griffith LG. Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28317948 DOI: 10.1039/c6ib00245e  1
2017 Maass C, Stokes CL, Griffith LG, Cirit M. Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS). Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28267162 DOI: 10.1039/c6ib00243a  0.4
2016 Tsamandouras N, Kostrzewski T, Stokes CL, Griffith LG, Hughes DJ, Cirit M. Quantitative assessment of population variability in hepatic drug metabolism using a perfused 3D human liver microphysiological system. The Journal of Pharmacology and Experimental Therapeutics. PMID 27760784 DOI: 10.1124/jpet.116.237495  0.4
2016 Long TJ, Cosgrove PA, Dunn RT, Stolz DB, Hamadeh HK, Afshari C, McBride H, Griffith LG. Modeling therapeutic antibody-small molecule drug-drug interactions using a 3D perfusable human liver co-culture platform. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27621203 DOI: 10.1124/dmd.116.071456  0.6
2016 de Picciotto S, Dickson PM, Traxlmayr MW, Marques BS, Socher E, Zhao S, Cheung S, Kiefer J, Wand AJ, Griffith LG, Imperiali B, Wittrup KD. Design principles for reagentless biosensors: Specific fluorophore/analyte binding and minimization of fluorophore/scaffold interactions. Journal of Molecular Biology. PMID 27448945 DOI: 10.1016/j.jmb.2016.07.004  1
2016 Nuschke A, Rodrigues M, Rivera J, Yates C, Whaley D, Stolz D, Griffith L, Wells A. Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Translational Medicine. PMID 27400798 DOI: 10.5966/sctm.2015-0326  0.56
2016 Clark AM, Ma B, Taylor DL, Griffith L, Wells A. Liver metastases: Microenvironments and ex-vivo models. Experimental Biology and Medicine (Maywood, N.J.). PMID 27390264 DOI: 10.1177/1535370216658144  1
2016 Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, et al. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. Altex. PMID 27180100 DOI: 10.14573/altex.1603161  0.32
2016 Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discovery. PMID 26984351 DOI: 10.1158/2159-8290.CD-15-0933  1
2016 Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nature Communications. 7: 10243. PMID 26732624 DOI: 10.1038/ncomms10243  0.32
2015 Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M. Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. Cpt: Pharmacometrics & Systems Pharmacology. 4: 585-94. PMID 26535159 DOI: 10.1002/psp4.12010  1
2015 Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Scientific Reports. 5: 15150. PMID 26477568 DOI: 10.1038/srep15150  1
2015 Ahrens CC, Welch ME, Griffith LG, Hammond PT. Uncharged Helical Modular Polypeptide Hydrogels for Cellular Scaffolds. Biomacromolecules. PMID 26461932 DOI: 10.1021/acs.biomac.5b01076  1
2015 Alvarez LM, Rivera JJ, Stockdale L, Saini S, Lee RT, Griffith LG. Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTCP) via Fusion to a High Affinity, Multimeric βTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors. Plos One. 10: e0129600. PMID 26121597 DOI: 10.1371/journal.pone.0129600  1
2015 Cambria E, Renggli K, Ahrens CC, Cook CD, Kroll C, Krueger AT, Imperiali B, Griffith LG. Covalent modification of synthetic hydrogels with bioactive proteins via sortase-mediated ligation. Biomacromolecules. PMID 26098148 DOI: 10.1021/acs.biomac.5b00549  1
2015 Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR. Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1091-9. PMID 25926431 DOI: 10.1124/dmd.115.063495  1
2015 Heath DE, Sharif AR, Ng CP, Rhoads MG, Griffith LG, Hammond PT, Chan-Park MB. Regenerating the cell resistance of micromolded PEG hydrogels. Lab On a Chip. 15: 2073-89. PMID 25813089 DOI: 10.1039/c4lc01416b  1
2015 Neiman JA, Raman R, Chan V, Rhoads MG, Raredon MS, Velazquez JJ, Dyer RL, Bashir R, Hammond PT, Griffith LG. Photopatterning of hydrogel scaffolds coupled to filter materials using stereolithography for perfused 3D culture of hepatocytes. Biotechnology and Bioengineering. 112: 777-87. PMID 25384798 DOI: 10.1002/bit.25494  1
2015 Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL. Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Stem Cell Reviews. 11: 511-25. PMID 25190668 DOI: 10.1007/s12015-014-9549-5  1
2014 Nuschke A, Rodrigues M, Stolz DB, Chu CT, Griffith L, Wells A. Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. Stem Cell Research & Therapy. 5: 140. PMID 25523618 DOI: 10.1186/scrt530  0.6
2014 Lee YH, Tan CW, Venkatratnam A, Tan CS, Cui L, Loh SF, Griffith L, Tannenbaum SR, Chan JK. Dysregulated sphingolipid metabolism in endometriosis. The Journal of Clinical Endocrinology and Metabolism. 99: E1913-21. PMID 24960545 DOI: 10.1210/jc.2014-1340  1
2014 Yu J, Carrier RL, March JC, Griffith LG. Three dimensional human small intestine models for ADME-Tox studies. Drug Discovery Today. 19: 1587-94. PMID 24853950 DOI: 10.1016/j.drudis.2014.05.003  1
2014 Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. A microphysiological system model of therapy for liver micrometastases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1170-9. PMID 24821820 DOI: 10.1177/1535370214532596  1
2014 de Picciotto S, Imperiali B, Griffith LG, Wittrup KD. Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors. Analytical Biochemistry. 460: 9-15. PMID 24814226 DOI: 10.1016/j.ab.2014.04.036  1
2014 Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug Discovery Today. 19: 754-62. PMID 24793141 DOI: 10.1016/j.drudis.2014.04.017  1
2014 Griffith LG, Wells A, Stolz DB. Engineering liver. Hepatology (Baltimore, Md.). 60: 1426-34. PMID 24668880 DOI: 10.1002/hep.27150  0.6
2014 Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG. Bioreactor technologies to support liver function in vitro. Advanced Drug Delivery Reviews. 69: 132-57. PMID 24607703 DOI: 10.1016/j.addr.2014.02.011  1
2014 Ng CP, Sharif AR, Heath DE, Chow JW, Zhang CB, Chan-Park MB, Hammond PT, Chan JK, Griffith LG. Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM. Biomaterials. 35: 4046-57. PMID 24560460 DOI: 10.1016/j.biomaterials.2014.01.081  1
2014 Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Science Translational Medicine. 6: 222ra16. PMID 24500404 DOI: 10.1126/scitranslmed.3007988  1
2014 Krueger AT, Kroll C, Sanchez E, Griffith LG, Imperiali B. Tailoring chimeric ligands for studying and biasing ErbB receptor family interactions. Angewandte Chemie (International Ed. in English). 53: 2662-6. PMID 24481645 DOI: 10.1002/anie.201307869  1
2014 Buck LD, Inman SW, Rusyn I, Griffith LG. Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix. Biotechnology and Bioengineering. 111: 1018-27. PMID 24222008 DOI: 10.1002/bit.25152  1
2013 Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, et al. All-human microphysical model of metastasis therapy. Stem Cell Research & Therapy. 4: S11. PMID 24565274 DOI: 10.1186/scrt372  1
2013 Tsukamoto K, Buck L, Inman W, Griffith L, Kocher O, Krieger M. Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1. Plos One. 8: e69725. PMID 23936087 DOI: 10.1371/journal.pone.0069725  1
2013 Wells A, Griffith L, Wells JZ, Taylor DP. The dormancy dilemma: quiescence versus balanced proliferation. Cancer Research. 73: 3811-6. PMID 23794703 DOI: 10.1158/0008-5472.CAN-13-0356  0.56
2013 Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 128: 152-61. PMID 23757312 DOI: 10.1161/CIRCULATIONAHA.113.002203  1
2013 Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: E2074-83. PMID 23674691 DOI: 10.1073/pnas.1222387110  1
2013 Rodrigues M, Yates CC, Nuschke A, Griffith L, Wells A. The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL. Tissue Engineering. Part A. 19: 1972-83. PMID 23541003 DOI: 10.1089/ten.TEA.2012.0568  1
2013 Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. Toxicology Research. 2: 23-39. PMID 23495363 DOI: 10.1039/C2TX20051A  1
2013 Luangphakdy V, Walker E, Shinohara K, Pan H, Hefferan T, Bauer TW, Stockdale L, Saini S, Dadsetan M, Runge MB, Vasanji A, Griffith L, Yaszemski M, Muschler GF. Evaluation of osteoconductive scaffolds in the canine femoral multi-defect model. Tissue Engineering. Part A. 19: 634-48. PMID 23215980 DOI: 10.1089/ten.TEA.2012.0289  1
2013 Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J. Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. Journal of the American Chemical Society. 135: 1645-8. PMID 23157326 DOI: 10.1021/ja307866z  1
2013 Rodrigues M, Blair H, Stockdale L, Griffith L, Wells A. Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis. Stem Cells (Dayton, Ohio). 31: 104-16. PMID 22948863 DOI: 10.1002/stem.1215  1
2012 Hong J, Alvarez LM, Shah NJ, Griffith LG, Kim BS, Char K, Hammond PT. Multilayer thin film coatings capable of extended programmable drug release: application to human mesenchymal stem cell differentiation. Drug Delivery and Translational Research. 2: 375-83. PMID 25485185 DOI: 10.1007/s13346-012-0093-z  1
2012 Chopko CM, Lowden EL, Engler AC, Griffith LG, Hammond PT. Dual responsiveness of a tunable thermo-sensitive polypeptide. Acs Macro Letters. 1: 727-731. PMID 24883233 DOI: 10.1021/mz300088w  1
2012 Oelker AM, Morey SM, Griffith LG, Hammond PT. Helix versus coil polypeptide macromers: gel networks with decoupled stiffness and permeability. Soft Matter. 42: 10887-10895. PMID 24575148 DOI: 10.1039/C2SM26487K  1
2012 Rodrigues M, Turner O, Stolz D, Griffith LG, Wells A. Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplantation. 21: 2171-87. PMID 22526333 DOI: 10.3727/096368912X639035  0.56
2012 Mito JK, Ferrer JM, Brigman BE, Lee CL, Dodd RD, Eward WC, Marshall LF, Cuneo KC, Carter JE, Ramasunder S, Kim Y, Lee WD, Griffith LG, Bawendi MG, Kirsch DG. Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer. 118: 5320-30. PMID 22437667 DOI: 10.1002/cncr.27458  1
2012 Stains CI, Tedford NC, Walkup TC, Lukovi? E, Goguen BN, Griffith LG, Lauffenburger DA, Imperiali B. Interrogating signaling nodes involved in cellular transformations using kinase activity probes. Chemistry & Biology. 19: 210-7. PMID 22365604 DOI: 10.1016/j.chembiol.2011.11.012  1
2012 Hang TC, Lauffenburger DA, Griffith LG, Stolz DB. Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G375-88. PMID 22075778 DOI: 10.1152/ajpgi.00288.2011  1
2011 Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, ... Griffith LG, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/jbc.M111.280495  1
2011 Inamdar NK, Griffith LG, Borenstein JT. Transport and shear in a microfluidic membrane bilayer device for cell culture. Biomicrofluidics. 5: 22213. PMID 21799719 DOI: 10.1063/1.3576925  0.32
2011 Wu S, Wells A, Griffith LG, Lauffenburger DA. Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials. 32: 7524-31. PMID 21782235 DOI: 10.1016/j.biomaterials.2011.06.050  1
2011 Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator. Journal of the American Chemical Society. 133: 10368-71. PMID 21671557 DOI: 10.1021/ja2036628  1
2011 Jay SM, Kurtagic E, Alvarez LM, de Picciotto S, Sanchez E, Hawkins JF, Prince RN, Guerrero Y, Treasure CL, Lee RT, Griffith LG. Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. The Journal of Biological Chemistry. 286: 27729-40. PMID 21622572 DOI: 10.1074/jbc.M111.221093  1
2011 Peyton SR, Kalcioglu ZI, Cohen JC, Runkle AP, Van Vliet KJ, Lauffenburger DA, Griffith LG. Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. Biotechnology and Bioengineering. 108: 1181-93. PMID 21449030 DOI: 10.1002/bit.23027  1
2011 Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA. Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 422-38. PMID 21180771 DOI: 10.1039/c0ib00083c  1
2011 Williams CM, Mehta G, Peyton SR, Zeiger AS, Van Vliet KJ, Griffith LG. Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays. Tissue Engineering. Part A. 17: 1055-68. PMID 21121876 DOI: 10.1089/ten.TEA.2010.0398  1
2010 Rodrigues M, Griffith LG, Wells A. Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Research & Therapy. 1: 32. PMID 20977782 DOI: 10.1186/scrt32  0.56
2010 Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular Biosystems. 6: 1195-206. PMID 20361094 DOI: 10.1039/b926287c  1
2010 Mehta G, Williams CM, Alvarez L, Lesniewski M, Kamm RD, Griffith LG. Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels. Biomaterials. 31: 4657-71. PMID 20304480 DOI: 10.1016/j.biomaterials.2010.01.138  1
2009 Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA. A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5452-5. PMID 19964679 DOI: 10.1109/IEMBS.2009.5334019  1
2009 Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells (Dayton, Ohio). 27: 2804-14. PMID 19750537 DOI: 10.1002/stem.215  1
2009 Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA. Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death. Molecular Cancer Therapeutics. 8: 2183-92. PMID 19671754 DOI: 10.1158/1535-7163.MCT-08-1203  1
2009 Dash A, Inman W, Hoffmaster K, Sevidal S, Kelly J, Obach RS, Griffith LG, Tannenbaum SR. Liver tissue engineering in the evaluation of drug safety. Expert Opinion On Drug Metabolism & Toxicology. 5: 1159-74. PMID 19637986 DOI: 10.1517/17425250903160664  1
2009 Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. Journal of Cellular Physiology. 221: 306-17. PMID 19544388 DOI: 10.1002/jcp.21854  1
2009 Marcantonio NA, Boehm CA, Rozic RJ, Au A, Wells A, Muschler GF, Griffith LG. The influence of tethered epidermal growth factor on connective tissue progenitor colony formation. Biomaterials. 30: 4629-38. PMID 19540579 DOI: 10.1016/j.biomaterials.2009.05.061  1
2009 Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicology and Applied Pharmacology. 237: 317-30. PMID 19362101 DOI: 10.1016/j.taap.2009.04.002  1
2008 Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology (Baltimore, Md.). 48: 276-88. PMID 18536058 DOI: 10.1002/hep.22335  1
2007 Zugates GT, Tedford NC, Zumbuehl A, Jhunjhunwala S, Kang CS, Griffith LG, Lauffenburger DA, Langer R, Anderson DG. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate Chemistry. 18: 1887-96. PMID 17929884 DOI: 10.1021/bc7002082  1
2007 Kuhlman W, Taniguchi I, Griffith LG, Mayes AM. Interplay between PEO tether length and ligand spacing governs cell spreading on RGD-modified PMMA-g-PEO comb copolymers. Biomacromolecules. 8: 3206-13. PMID 17877394 DOI: 10.1021/bm070237o  1
2007 Eshghi S, Vogelezang MG, Hynes RO, Griffith LG, Lodish HF. Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. The Journal of Cell Biology. 177: 871-80. PMID 17548514 DOI: 10.1083/jcb.200702080  1
2007 Shuga J, Zhang J, Samson LD, Lodish HF, Griffith LG. In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds. Proceedings of the National Academy of Sciences of the United States of America. 104: 8737-42. PMID 17502613 DOI: 10.1073/pnas.0701829104  0.28
2007 Fan VH, Tamama K, Au A, Littrell R, Richardson LB, Wright JW, Wells A, Griffith LG. Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells. Stem Cells (Dayton, Ohio). 25: 1241-51. PMID 17234993 DOI: 10.1634/stemcells.2006-0320  0.56
2007 Au A, Boehm CA, Mayes AM, Muschler GF, Griffith LG. Formation of osteogenic colonies on well-defined adhesion peptides by freshly isolated human marrow cells. Biomaterials. 28: 1847-61. PMID 17222453 DOI: 10.1016/j.biomaterials.2006.12.009  1
2006 Kuhlman WA, Olivetti EA, Griffith LG, Mayes AM. Chain Conformations at the Surface of a Polydisperse Amphiphilic Comb Copolymer Film. Macromolecules. 39: 5122-5126. PMID 19079731 DOI: 10.1021/ma060132y  1
2006 Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of Cell Science. 119: 3788-98. PMID 16940353 DOI: 10.1242/jcs.03102  1
2006 Wells A, Harms B, Iwabu A, Koo L, Smith K, Griffith L, Lauffenburger DA. Motility signaled from the EGF receptor and related systems Methods in Molecular Biology (Clifton, N.J.). 327: 159-177. PMID 16780220  1
2006 Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nature Reviews. Molecular Cell Biology. 7: 211-24. PMID 16496023 DOI: 10.1038/nrm1858  0.8
2006 Griffith L, Swartz M, Tranquillo R. Education for careers in tissue engineering and regenerative medicine. Annals of Biomedical Engineering. 34: 265-9. PMID 16450189 DOI: 10.1007/s10439-005-9038-8  1
2005 Sivaraman A, Leach JK, Townsend S, Iida T, Hogan BJ, Stolz DB, Fry R, Samson LD, Tannenbaum SR, Griffith LG. A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Current Drug Metabolism. 6: 569-91. PMID 16379670 DOI: 10.2174/138920005774832632  1
2005 Varga CM, Tedford NC, Thomas M, Klibanov AM, Griffith LG, Lauffenburger DA. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Therapy. 12: 1023-32. PMID 15815703 DOI: 10.1038/sj.gt.3302495  1
2004 Lu H, Koo LY, Wang WM, Lauffenburger DA, Griffith LG, Jensen KF. Microfluidic shear devices for quantitative analysis of cell adhesion. Analytical Chemistry. 76: 5257-64. PMID 15362881 DOI: 10.1021/ac049837t  1
2003 Lee HS, Crane GG, Merok JR, Tunstead JR, Hatch NL, Panchalingam K, Powers MJ, Griffith LG, Sherley JL. Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK). Biotechnology and Bioengineering. 83: 760-71. PMID 12889016 DOI: 10.1002/bit.10727  1
2002 Koegler WS, Patrick C, Cima MJ, Griffith LG. Carbon dioxide extraction of residual chloroform from biodegradable polymers. Journal of Biomedical Materials Research. 63: 567-76. PMID 12209902 DOI: 10.1002/jbm.10209  1
2002 Powers MJ, Janigian DM, Wack KE, Baker CS, Stolz DB, Griffith LG. Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor Tissue Engineering. 8: 499-513. PMID 12167234 DOI: 10.1089/107632702760184745  1
2002 Powers MJ, Domansky K, Kaazempur-Mofrad MR, Kalezi A, Capitano A, Upadhyaya A, Kurzawski P, Wack KE, Stolz DB, Kamm R, Griffith LG. A microfabricated array bioreactor for perfused 3D liver culture. Biotechnology and Bioengineering. 78: 257-69. PMID 11920442 DOI: 10.1002/bit.10143  1
2002 Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG. Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. Journal of Cell Science. 115: 1423-33. PMID 11896190  1
2002 Irvine DJ, Hue KA, Mayes AM, Griffith LG. Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands. Biophysical Journal. 82: 120-32. PMID 11751301 DOI: 10.1016/S0006-3495(02)75379-4  1
2001 Irvine DJ, Ruzette AV, Mayes AM, Griffith LG. Nanoscale clustering of RGD peptides at surfaces using comb polymers. 2. Surface segregation of comb polymers in polylactide. Biomacromolecules. 2: 545-56. PMID 11749219 DOI: 10.1021/bm015510f  1
2001 Irvine DJ, Mayes AM, Griffith LG. Nanoscale clustering of RGD peptides at surfaces using Comb polymers. 1. Synthesis and characterization of Comb thin films. Biomacromolecules. 2: 85-94. PMID 11749159 DOI: 10.1021/bm005584b  1
2001 Lauffenburger DA, Griffith LG. Who's got pull around here? Cell organization in development and tissue engineering. Proceedings of the National Academy of Sciences of the United States of America. 98: 4282-4. PMID 11296276 DOI: 10.1073/pnas.081083698  1
2001 Griffith LG, Grodzinsky AJ. Advances in biomedical engineering. Jama. 285: 556-61. PMID 11176858 DOI: 10.1001/jama.285.5.556  0.32
2000 Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA. Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnology and Bioengineering. 69: 607-17. PMID 10918135 DOI: 10.1002/1097-0290(20000920)69:6<607::AID-BIT4>3.0.CO;2-F  1
2000 Maheshwari G, Brown G, Lauffenburger DA, Wells A, Griffith LG. Cell adhesion and motility depend on nanoscale RGD clustering. Journal of Cell Science. 113: 1677-86. PMID 10769199  1
2000 Banerjee P, Irvine DJ, Mayes AM, Griffith LG. Polymer latexes for cell-resistant and cell-interactive surfaces. Journal of Biomedical Materials Research. 50: 331-9. PMID 10737874 DOI: 10.1002/(SICI)1097-4636(20000605)50:3<331::AID-JBM6>3.0.CO;2-T  1
1999 Maheshwari G, Wells A, Griffith LG, Lauffenburger DA. Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophysical Journal. 76: 2814-23. PMID 10233097 DOI: 10.1016/S0006-3495(99)77435-7  1
1998 Powers MJ, Griffith LG. Adhesion-guided in vitro morphogenesis in pure and mixed cell cultures. Microscopy Research and Technique. 43: 379-84. PMID 9858335 DOI: 10.1002/(SICI)1097-0029(19981201)43:5<379::AID-JEMT4>3.0.CO;2-0  1
1998 Kim SS, Utsunomiya H, Koski JA, Wu BM, Cima MJ, Sohn J, Mukai K, Griffith LG, Vacanti JP. Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Annals of Surgery. 228: 8-13. PMID 9671060  1
1998 Irvine DJ, Mayes AM, Satija SK, Barker JG, Sofia-Allgor SJ, Griffith LG. Comparison of tethered star and linear poly(ethylene oxide) for control of biomaterials surface properties. Journal of Biomedical Materials Research. 40: 498-509. PMID 9570083 DOI: 10.1002/(SICI)1097-4636(19980605)40:3<498::AID-JBM21>3.0.CO;2-E  1
1998 Park A, Wu B, Griffith LG. Integration of surface modification and 3D fabrication techniques to prepare patterned poly(L-lactide) substrates allowing regionally selective cell adhesion. Journal of Biomaterials Science. Polymer Edition. 9: 89-110. PMID 9493839  1
1997 Powers MJ, Rodriguez RE, Griffith LG. Cell-substratum adhesion strength as a determinant of hepatocyte aggregate morphology. Biotechnology and Bioengineering. 53: 415-26. PMID 18634032 DOI: 10.1002/(SICI)1097-0290(19970220)53:4<415::AID-BIT10>3.0.CO;2-F  1
1997 Griffith LG, Wu B, Cima MJ, Powers MJ, Chaignaud B, Vacanti JP. In vitro organogenesis of liver tissue Annals of the New York Academy of Sciences. 831: 382-397. PMID 9616729  1
1996 Paige KT, Cima LG, Yaremchuk MJ, Schloo BL, Vacanti JP, Vacanti CA. De novo cartilage generation using calcium alginate-chondrocyte constructs. Plastic and Reconstructive Surgery. 97: 168-78; discussion 1. PMID 8532775  0.52
1995 Paige KT, Cima LG, Yaremchuk MJ, Vacanti JP, Vacanti CA. Injectable cartilage. Plastic and Reconstructive Surgery. 96: 1390-8; discussion 1. PMID 7480239  0.44
1994 Cima LG, Discher DE, Tong J, Williams MC. A hydrodynamic interpretation of crisis in sickle cell anemia. Microvascular Research. 47: 41-54. PMID 8022313 DOI: 10.1006/mvre.1994.1004  0.36
1994 Cima LG. Polymer substrates for controlled biological interactions. Journal of Cellular Biochemistry. 56: 155-61. PMID 7829573 DOI: 10.1002/jcb.240560206  0.4
1993 Cohen S, Baño MC, Cima LG, Allcock HR, Vacanti JP, Vacanti CA, Langer R. Design of synthetic polymeric structures for cell transplantation and tissue engineering. Clinical Materials. 13: 3-10. PMID 10146238  0.36
1993 Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R. Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. Journal of Biomedical Materials Research. 27: 183-9. PMID 8382203 DOI: 10.1002/jbm.820270207  0.56
1993 Atala A, Cima LG, Kim W, Paige KT, Vacanti JP, Retik AB, Vacanti CA. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. The Journal of Urology. 150: 745-7. PMID 8326638  0.2
1991 Cima LG, Ingber DE, Vacanti JP, Langer R. Hepatocyte culture on biodegradable polymeric substrates. Biotechnology and Bioengineering. 38: 145-58. PMID 18600745 DOI: 10.1002/bit.260380207  0.28
1991 Cima LG, Vacanti JP, Vacanti C, Ingber D, Mooney D, Langer R. Tissue engineering by cell transplantation using degradable polymer substrates. Journal of Biomechanical Engineering. 113: 143-51. PMID 1652042 DOI: 10.1115/1.2891228  0.48
1990 Langer R, Cima LG, Tamada JA, Wintermantel E. Future directions in biomaterials. Biomaterials. 11: 738-45. PMID 2090313  0.24
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