Alexandra C. Newton, PhD - Publications

Affiliations: 
1988-1995 Chemistry Indiana University, Bloomington, Bloomington, IN, United States 
 1995- Pharmacology University of California, San Diego, La Jolla, CA 
Area:
Protein kinase C
Website:
https://profiles.ucsd.edu/alexandra.newton

158 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Baffi TR, Katsenelson KC, Newton AC. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling. Annual Review of Pharmacology and Toxicology. PMID 32997603 DOI: 10.1146/annurev-pharmtox-031820-122108  0.4
2019 Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Elife. 8. PMID 31408005 DOI: 10.7554/eLife.48609  1
2019 Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, et al. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. The Journal of Cell Biology. PMID 31092557 DOI: 10.1083/jcb.201902048  1
2019 Baffi TR, Van AN, Zhao W, Mills GB, Newton AC. Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. Molecular Cell. PMID 30904392 DOI: 10.1016/j.molcel.2019.02.018  1
2019 Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nature Cell Biology. PMID 30804505 DOI: 10.1038/s41556-019-0291-8  1
2019 Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC. Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. Science Signaling. 12. PMID 30600259 DOI: 10.1126/scisignal.aat6662  1
2018 Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC. Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844158 DOI: 10.1073/pnas.1805046115  1
2018 Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity. The Journal of Biological Chemistry. PMID 29773654 DOI: 10.1074/jbc.RA118.002357  1
2018 Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, et al. Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. Scientific Reports. 8: 6518. PMID 29695735 DOI: 10.1038/s41598-018-24457-1  1
2018 Newton AC. Protein kinase C: perfectly balanced. Critical Reviews in Biochemistry and Molecular Biology. 53: 208-230. PMID 29513138 DOI: 10.1080/10409238.2018.1442408  0.01
2017 Callender JA, Newton AC. Conventional protein kinase C in the brain: 40 years later. Neuronal Signaling. 1: NS20160005. PMID 32714576 DOI: 10.1042/NS20160005  1
2017 Newton AC. Protein Kinase C as a Tumor Suppressor. Seminars in Cancer Biology. PMID 28476658 DOI: 10.1016/j.semcancer.2017.04.017  0.01
2017 Newton AC, Brognard J. Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends in Pharmacological Sciences. PMID 28283201 DOI: 10.1016/j.tips.2017.02.002  1
2016 Grzechnik AT, Newton AC. PHLPPing through history: a decade in the life of PHLPP phosphatases. Biochemical Society Transactions. 44: 1675-1682. PMID 27913677 DOI: 10.1042/BST20160170  0.01
2016 McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N. KinView: a visual comparative sequence analysis tool for integrated kinome research. Molecular Biosystems. PMID 27731453 DOI: 10.1039/c6mb00466k  1
2016 Newton AC, Bootman MD, Scott JD. Second Messengers. Cold Spring Harbor Perspectives in Biology. 8. PMID 27481708 DOI: 10.1101/cshperspect.a005926  1
2016 Newton AC, Antal CE, Steinberg SF. Protein kinase C mechanisms that contribute to cardiac remodelling. Clinical Science (London, England : 1979). 130: 1499-510. PMID 27433023 DOI: 10.1042/CS20160036  1
2016 Scott JD, Newton AC. Bacterial spore coat protein kinases: A new twist to an old story. Proceedings of the National Academy of Sciences of the United States of America. PMID 27286827 DOI: 10.1073/pnas.1607004113  1
2016 Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Ali SR, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V. Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity. The Journal of Biological Chemistry. PMID 27226531 DOI: 10.1074/jbc.M115.695866  1
2016 Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Science Signaling. 9: ra47. PMID 27165780 DOI: 10.1126/scisignal.aaf6209  1
2016 Newton AC, Tanzi RE, VanHook AM. Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease. Science Signaling. 9: pc11. PMID 27165779 DOI: 10.1126/scisignal.aaf9436  0.01
2016 Tobias IS, Newton AC. Protein Scaffolds Control Localized Protein Kinase Cζ Activity. The Journal of Biological Chemistry. 291: 13809-22. PMID 27143478 DOI: 10.1074/jbc.M116.729483  1
2016 Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA. Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget. PMID 26989024 DOI: 10.18632/oncotarget.8062  1
2015 Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. The Biochemical Journal. PMID 26635352 DOI: 10.1042/BJ20151013  1
2015 Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Reports. 12: 1252-60. PMID 26279568 DOI: 10.1016/j.celrep.2015.07.039  1
2015 Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. The Journal of Biological Chemistry. PMID 26187466 DOI: 10.1074/jbc.M115.676221  1
2015 Bradley EW, Carpio LR, Newton AC, Westendorf JJ. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. The Journal of Biological Chemistry. 290: 16272-80. PMID 25953896 DOI: 10.1074/jbc.M114.612937  1
2015 Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proceedings of the National Academy of Sciences of the United States of America. 112: E937-46. PMID 25713130 DOI: 10.1073/pnas.1420140112  1
2015 Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 160: 489-502. PMID 25619690 DOI: 10.1016/j.cell.2015.01.001  1
2015 Kunkel MT, Newton AC. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chemistry & Biology. 22: 98-106. PMID 25556943 DOI: 10.1016/j.chembiol.2014.11.014  1
2014 Antal CE, Newton AC. Tuning the signalling output of protein kinase C. Biochemical Society Transactions. 42: 1477-83. PMID 25399557 DOI: 10.1042/BST20140172  1
2014 Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proceedings of the National Academy of Sciences of the United States of America. 111: E3957-65. PMID 25201979 DOI: 10.1073/pnas.1404221111  1
2014 Sierecki E, Newton AC. Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry. 53: 3971-81. PMID 24892992 DOI: 10.1021/bi500428j  1
2014 Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Molecular Cell. 54: 378-91. PMID 24703948 DOI: 10.1016/j.molcel.2014.03.007  1
2014 Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. Intramolecular conformational changes optimize protein kinase C signaling. Chemistry & Biology. 21: 459-69. PMID 24631122 DOI: 10.1016/j.chembiol.2014.02.008  1
2014 Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE. Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. The Journal of Biological Chemistry. 289: 8781-98. PMID 24500718 DOI: 10.1074/jbc.M113.533265  1
2014 Newton AC, Trotman LC. Turning off AKT: PHLPP as a drug target. Annual Review of Pharmacology and Toxicology. 54: 537-58. PMID 24392697 DOI: 10.1146/annurev-pharmtox-011112-140338  0.2
2014 Kunkel MT, Newton AC. Imaging kinase activity at protein scaffolds. Methods in Molecular Biology (Clifton, N.J.). 1071: 129-37. PMID 24052385 DOI: 10.1007/978-1-62703-622-1_10  1
2013 Antal CE, Newton AC. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Molecular & Cellular Proteomics : McP. 12: 3498-508. PMID 23788531 DOI: 10.1074/mcp.R113.029819  1
2013 Wu-Zhang AX, Newton AC. Protein kinase C pharmacology: refining the toolbox. The Biochemical Journal. 452: 195-209. PMID 23662807 DOI: 10.1042/BJ20130220  1
2013 Scott AM, Antal CE, Newton AC. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. The Journal of Biological Chemistry. 288: 16905-15. PMID 23589289 DOI: 10.1074/jbc.M113.467456  1
2013 O'Neill AK, Niederst MJ, Newton AC. Suppression of survival signalling pathways by the phosphatase PHLPP. The Febs Journal. 280: 572-83. PMID 22340730 DOI: 10.1111/j.1742-4658.2012.08537.x  1
2012 Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. The Journal of Biological Chemistry. 287: 37891-906. PMID 22988234 DOI: 10.1074/jbc.M112.412635  1
2012 de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chemistry & Biology. 19: 994-1000. PMID 22921066 DOI: 10.1016/j.chembiol.2012.06.010  1
2012 Scott JD, Newton AC. Shedding light on local kinase activation. Bmc Biology. 10: 61. PMID 22805055 DOI: 10.1186/1741-7007-10-61  1
2012 Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. The Journal of Biological Chemistry. 287: 12879-85. PMID 22378786 DOI: 10.1074/jbc.M112.357244  1
2012 Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. The Journal of Biological Chemistry. 287: 13262-78. PMID 22318721 DOI: 10.1074/jbc.M112.349753  1
2012 O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM. Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 26: 1689-92. PMID 22237780 DOI: 10.1038/leu.2012.6  1
2012 Warfel NA, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. The Journal of Biological Chemistry. 287: 3610-6. PMID 22144674 DOI: 10.1074/jbc.R111.318675  1
2011 O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). The Journal of Biological Chemistry. 286: 43559-68. PMID 22027822 DOI: 10.1074/jbc.M111.294603  1
2011 Warfel NA, Niederst M, Newton AC. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. The Journal of Biological Chemistry. 286: 39122-9. PMID 21908613 DOI: 10.1074/jbc.M111.278747  1
2011 Gallegos LL, Newton AC. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods in Molecular Biology (Clifton, N.J.). 756: 295-310. PMID 21870234 DOI: 10.1007/978-1-61779-160-4_17  1
2011 Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, ... ... Newton AC, et al. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 20: 173-86. PMID 21840483 DOI: 10.1016/j.ccr.2011.07.013  1
2011 Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. The Journal of Biological Chemistry. 286: 33390-400. PMID 21795686 DOI: 10.1074/jbc.M111.246447  1
2011 Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form Journal of Biological Chemistry. 286: 28922-28930. PMID 21715334 DOI: 10.1074/jbc.M111.272526  1
2011 Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). The Journal of Biological Chemistry. 286: 23552-8. PMID 21561857 DOI: 10.1074/jbc.M111.258004  1
2011 Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 5533-7. PMID 21498666 DOI: 10.4049/jimmunol.1002126  1
2011 Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt Journal of Biological Chemistry. 286: 19777-19788. PMID 21454620 DOI: 10.1074/jbc.M111.237081  1
2011 Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2113-24. PMID 21307248 DOI: 10.1523/JNEUROSCI.2139-10.2011  1
2010 Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC. Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. The Journal of Biological Chemistry. 285: 41896-910. PMID 20959447 DOI: 10.1074/jbc.M110.184028  1
2010 Sierecki E, Sinko W, McCammon JA, Newton AC. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. Journal of Medicinal Chemistry. 53: 6899-911. PMID 20836557 DOI: 10.1021/jm100331d  1
2010 Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circulation Research. 107: 476-84. PMID 20576936 DOI: 10.1161/CIRCRESAHA.109.215020  1
2010 Kunkel MT, Newton AC. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at golgi membranes Journal of Biological Chemistry. 285: 22748-22752. PMID 20519514 DOI: 10.1074/jbc.C110.123133  1
2010 Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Molecular Cell. 37: 541-50. PMID 20188672 DOI: 10.1016/j.molcel.2010.01.014  1
2010 Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proceedings of the National Academy of Sciences of the United States of America. 107: 1642-7. PMID 20080691 DOI: 10.1073/pnas.0910292107  1
2010 Newton AC. Protein kinase C: poised to signal. American Journal of Physiology. Endocrinology and Metabolism. 298: E395-402. PMID 19934406 DOI: 10.1152/ajpendo.00477.2009  0.01
2009 Kunkel MT, Newton AC. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Current Protocols in Chemical Biology. 1: 17-18. PMID 21804950 DOI: 10.1002/9780470559277.ch090106  1
2009 Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. The Journal of Biological Chemistry. 284: 24653-61. PMID 19581308 DOI: 10.1074/jbc.M109.024547  1
2009 Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. The Journal of Biological Chemistry. 284: 15215-23. PMID 19324870 DOI: 10.1074/jbc.M901468200  1
2009 Gould CM, Kannan N, Taylor SS, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. The Journal of Biological Chemistry. 284: 4921-35. PMID 19091746 DOI: 10.1074/jbc.M808436200  1
2009 Newton AC. Lipid activation of protein kinases. Journal of Lipid Research. 50: S266-71. PMID 19033211 DOI: 10.1194/jlr.R800064-JLR200  0.01
2008 Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Molecular Cell. 32: 169-79. PMID 18951085 DOI: 10.1016/j.molcel.2008.08.030  1
2008 Gallegos LL, Newton AC. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. Iubmb Life. 60: 782-9. PMID 18720411 DOI: 10.1002/iub.122  1
2008 Gould CM, Newton AC. The life and death of protein kinase C Current Drug Targets. 9: 614-625. PMID 18691009 DOI: 10.2174/138945008785132411  1
2008 Newton AC. Protein kinase C. Iubmb Life. 60: 765-8. PMID 18683875 DOI: 10.1002/iub.118  0.01
2008 Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. The Embo Journal. 27: 1932-43. PMID 18566586 DOI: 10.1038/emboj.2008.120  1
2008 Brognard J, Newton AC. PHLiPPing the switch on Akt and protein kinase C signaling. Trends in Endocrinology and Metabolism: Tem. 19: 223-30. PMID 18511290 DOI: 10.1016/j.tem.2008.04.001  1
2008 Dries DR, Newton AC. Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. The Journal of Biological Chemistry. 283: 7885-93. PMID 18187412 DOI: 10.1074/jbc.M709943200  1
2008 Gao T, Brognard J, Newton AC. The phosphatase PHLPP controls the cellular levels of protein kinase C. The Journal of Biological Chemistry. 283: 6300-11. PMID 18162466 DOI: 10.1074/jbc.M707319200  1
2007 Newton AC, Mochly-Rosen D. Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007). Iubmb Life. 59: 741-3. PMID 18085473 DOI: 10.1080/15216540701697438  1
2007 Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87. PMID 17893151 DOI: 10.1074/jbc.M703320200  1
2007 Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molecular Cell. 25: 917-31. PMID 17386267 DOI: 10.1016/j.molcel.2007.02.017  1
2007 Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of Biological Chemistry. 282: 6733-42. PMID 17189263 DOI: 10.1074/jbc.M608086200  1
2007 Dries DR, Gallegos LL, Newton AC. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. The Journal of Biological Chemistry. 282: 826-30. PMID 17071619 DOI: 10.1074/jbc.C600268200  1
2006 Gao T, Newton AC. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70 Journal of Biological Chemistry. 281: 32461-32468. PMID 16954220 DOI: 10.1074/jbc.M604076200  1
2006 Gallegos LL, Kunkel MT, Newton AC. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. The Journal of Biological Chemistry. 281: 30947-56. PMID 16901905 DOI: 10.1074/jbc.M603741200  1
2006 Giorgione JR, Lin JH, McCammon JA, Newton AC. Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. The Journal of Biological Chemistry. 281: 1660-9. PMID 16293612 DOI: 10.1074/jbc.M510251200  1
2005 Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular Cell. 18: 13-24. PMID 15808505 DOI: 10.1016/j.molcel.2005.03.008  1
2005 Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of Biological Chemistry. 280: 5581-7. PMID 15583002 DOI: 10.1074/jbc.M411534200  1
2004 King CC, Newton AC. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1 Journal of Biological Chemistry. 279: 37518-37527. PMID 15210700 DOI: 10.1074/jbc.M405340200  1
2004 Newton AC. Diacylglycerol's affair with protein kinase C turns 25. Trends in Pharmacological Sciences. 25: 175-7. PMID 15116719 DOI: 10.1016/j.tips.2004.02.010  0.01
2004 Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. The Journal of Biological Chemistry. 279: 4829-39. PMID 14594954 DOI: 10.1074/jbc.M311196200  1
2003 Violin JD, Newton AC. Pathway illuminated: visualizing protein kinase C signaling. Iubmb Life. 55: 653-60. PMID 14769001 DOI: 10.1080/152165401310001642216  1
2003 Giorgione J, Hysell M, Harvey DF, Newton AC. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry. 42: 11194-202. PMID 14503869 DOI: 10.1021/bi0350046  1
2003 Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 100: 9470-5. PMID 12881490 DOI: 10.1073/pnas.1633695100  1
2003 Nalefski EA, Newton AC. Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods in Molecular Biology (Clifton, N.J.). 233: 115-28. PMID 12840503 DOI: 10.1385/1-59259-397-6:115  1
2003 Giorgione J, Newton AC. Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods in Molecular Biology (Clifton, N.J.). 233: 105-13. PMID 12840502 DOI: 10.1385/1-59259-397-6:105  1
2003 Newton AC. Measuring the interaction of protein kinase C with membranes: an introduction. Methods in Molecular Biology (Clifton, N.J.). 233: 89-92. PMID 12840500 DOI: 10.1385/1-59259-397-6:89  0.01
2003 Newton AC. The ins and outs of protein kinase C. Methods in Molecular Biology (Clifton, N.J.). 233: 3-7. PMID 12840493 DOI: 10.1385/1-59259-397-6:3  0.01
2003 Bertolini TM, Giorgione J, Harvey DF, Newton AC. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. The Journal of Organic Chemistry. 68: 5028-36. PMID 12816455 DOI: 10.1021/jo030029w  1
2003 Adams RA, Liu X, Williams DS, Newton AC. Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. The Biochemical Journal. 374: 537-43. PMID 12809555 DOI: 10.1042/BJ20030408  1
2003 Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of Cell Biology. 161: 899-909. PMID 12782683 DOI: 10.1083/jcb.200302125  1
2003 Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. The Biochemical Journal. 370: 361-71. PMID 12495431 DOI: 10.1042/BJ20021626  0.01
2002 Gao T, Newton AC. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C Journal of Biological Chemistry. 277: 31585-31592. PMID 12080070 DOI: 10.1074/jbc.M204335200  1
2002 Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (New York, N.Y.). 296: 913-6. PMID 11988576 DOI: 10.1126/science.1068539  1
2002 Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A. Regulation of novel protein kinase C epsilon by phosphorylation. The Biochemical Journal. 363: 537-45. PMID 11964154 DOI: 10.1042/0264-6021:3630537  1
2002 Newton AC. Analyzing protein kinase C activation. Methods in Enzymology. 345: 499-506. PMID 11665632  0.01
2001 Perkins GA, Wang L, Huang LJ, Humphries K, Yao VJ, Martone M, Deerinck TJ, Barraclough DM, Violin JD, Smith D, Newton A, Scott JD, Taylor SS, Ellisman MH. PKA, PKC, and AKAP localization in and around the neuromuscular junction. Bmc Neuroscience. 2: 17. PMID 11716788  1
2001 Nalefski EA, Newton AC. Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain. Biochemistry. 40: 13216-29. PMID 11683630 DOI: 10.1021/BI010761U  1
2001 Sonnenburg ED, Gao T, Newton AC. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 276: 45289-97. PMID 11579098 DOI: 10.1074/jbc.M107416200  1
2001 Gao T, Toker A, Newton AC. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. The Journal of Biological Chemistry. 276: 19588-96. PMID 11376011 DOI: 10.1074/jbc.M101357200  1
2000 Johnson JE, Giorgione J, Newton AC. The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. Biochemistry. 39: 11360-9. PMID 10985781  1
2000 Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616 DOI: 10.1152/ajplung.2000.279.3.L429  1
2000 King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1 Journal of Biological Chemistry. 275: 18108-18113. PMID 10748151 DOI: 10.1074/jbc.M909663199  1
2000 Dutil EM, Newton AC. Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol. The Journal of Biological Chemistry. 275: 10697-701. PMID 10744767  0.76
1999 Faux MC, Rollins EN, Edwards AS, Langeberg LK, Newton AC, Scott JD. Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. The Biochemical Journal. 343: 443-52. PMID 10510312  1
1999 Behn-Krappa A, Newton AC. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Current Biology : Cb. 9: 728-37. PMID 10421574 DOI: 10.1016/S0960-9822(99)80332-7  1
1999 Edwards AS, Faux MC, Scott JD, Newton AC. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. The Journal of Biological Chemistry. 274: 6461-8. PMID 10037738  1
1998 Dutil EM, Toker A, Newton AC. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Current Biology : Cb. 8: 1366-75. PMID 9889098 DOI: 10.1016/S0960-9822(98)00017-7  1
1998 Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Current Biology : Cb. 8: 1069-77. PMID 9768361 DOI: 10.1016/S0960-9822(98)70444-0  1
1998 Newton AC, Johnson JE. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochimica Et Biophysica Acta. 1376: 155-72. PMID 9748550  0.68
1998 Johnson JE, Zimmerman ML, Daleke DL, Newton AC. Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine. Biochemistry. 37: 12020-5. PMID 9724512 DOI: 10.1021/bi981107q  1
1997 Edwards AS, Newton AC. Regulation of protein kinase C betaII by its C2 domain. Biochemistry. 36: 15615-23. PMID 9398289 DOI: 10.1021/bi9718752  0.96
1997 Johnson JE, Edwards AS, Newton AC. A putative phosphatidylserine binding motif is not involved in the lipid regulation of protein kinase C. The Journal of Biological Chemistry. 272: 30787-92. PMID 9388219  0.96
1997 Williams DS, Liu X, Schlamp CL, Ondek B, Jaken S, Newton AC. Characterization of protein kinase C in photoreceptor outer segments. Journal of Neurochemistry. 69: 1693-702. PMID 9326298  1
1997 Keranen LM, Newton AC. Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation. The Journal of Biological Chemistry. 272: 25959-67. PMID 9325330  1
1997 Edwards AS, Newton AC. Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. The Journal of Biological Chemistry. 272: 18382-90. PMID 9218480  0.96
1997 Greene NM, Williams DS, Newton AC. Identification of protein kinase C phosphorylation sites on bovine rhodopsin Journal of Biological Chemistry. 272: 10341-10344. PMID 9099669 DOI: 10.1074/jbc.272.16.10341  1
1997 Udovichenko IP, Newton AC, Williams DS. Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas Journal of Biological Chemistry. 272: 7952-7959. PMID 9065465 DOI: 10.1074/jbc.272.12.7952  1
1997 Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Science : a Publication of the Protein Society. 6: 477-80. PMID 9041654 DOI: 10.1002/pro.5560060228  1
1996 Arnold RS, Newton AC. Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid. Journal of Cellular Biochemistry. 62: 516-28. PMID 8891897 DOI: 10.1002/(SICI)1097-4644(19960915)62:4%3C516::AID-JCB9%3E3.0.CO;2-P  0.96
1996 Arnold RS, Newton AC. Diacylglycerol directly stimulates the insulin receptor tyrosine kinase. Febs Letters. 380: 58-62. PMID 8603747  0.96
1995 Keranen LM, Dutil EM, Newton AC. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Current Biology : Cb. 5: 1394-1403. PMID 8749392  1
1995 Greener NM, Williams DS, Newton AC. Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C Journal of Biological Chemistry. 270: 6710-6717. PMID 7896814 DOI: 10.1074/jbc.270.12.6710  1
1994 Newton AC, Keranen LM. Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes. Biochemistry. 33: 6651-8. PMID 8204602  1
1994 Daleke DL, Huestis WH, Newton AC. Protein kinase C as a measure of transbilayer phosphatidylserine asymmetry Analytical Biochemistry. 217: 33-40. PMID 8203737 DOI: 10.1006/abio.1994.1080  1
1994 Orr JW, Newton AC. Intrapeptide regulation of protein kinase C. The Journal of Biological Chemistry. 269: 8383-7. PMID 8132562  1
1994 Dutil EM, Keranen LM, DePaoli-Roach AA, Newton AC. In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation Journal of Biological Chemistry. 269: 29359-29362. PMID 7961910  1
1994 Orr JW, Newton AC. Requirement for negative charge on "activation loop" of protein kinase C. The Journal of Biological Chemistry. 269: 27715-8. PMID 7961692  1
1994 Williams DS, Park S, Schlamp CL, Newton AC. Protein kinase C association with the retinal cytoskeleton and phosphorylation of vimentin Experimental Eye Research. 58: 747-759. PMID 7925714 DOI: 10.1006/exer.1994.1072  1
1994 Conrad R, Keranen LM, Ellington AD, Newton AC. Isozyme-specific inhibition of protein kinase C by RNA aptamers. The Journal of Biological Chemistry. 269: 32051-4. PMID 7528207  1
1993 Newton AC, Williams DS. Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors Journal of Biological Chemistry. 268: 18181-18186. PMID 8349693  1
1993 Newton AC, Williams DS. Does protein kinase C play a role in rhodopsin desensitization? Trends in Biochemical Sciences. 18: 275-277. PMID 8236436 DOI: 10.1016/0968-0004(93)90032-I  1
1993 Nickells RW, Schlamp CL, Newton AC, Williams DS. Gene expression of the neuropeptide-processing enzyme carboxypeptidase E in rat photoreceptor cells. Journal of Neurochemistry. 61: 1891-900. PMID 7693871  1
1992 Orr JW, Keranen LM, Newton AC. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. The Journal of Biological Chemistry. 267: 15263-6. PMID 1639770  1
1992 Orr JW, Newton AC. Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation. Biochemistry. 31: 4667-73. PMID 1581317  1
1992 Orr JW, Newton AC. Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding. Biochemistry. 31: 4661-7. PMID 1581316  1
1991 Newton AC, Williams DS. Involvement of protein kinase C in the phosphorylation of rhodopsin Journal of Biological Chemistry. 266: 17725-17728. PMID 1917916  1
1991 Arnold RS, Newton AC. Inhibition of the insulin receptor tyrosine kinase by sphingosine. Biochemistry. 30: 7747-54. PMID 1651108  0.96
1990 Newton AC, Koshland DE. Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. Biochemistry. 29: 6656-61. PMID 2397206  1
1989 Newton AC, Koshland DE. High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction. The Journal of Biological Chemistry. 264: 14909-15. PMID 2768246  1
1988 Newton AC, Huestis WH. Vesicle-to-cell protein transfer: Insertion of band 3, the erythrocyte anion transporter, into lymphoid cells Biochemistry. 27: 4655-4659. PMID 3167008  1
1988 Newton AC, Huestis WH. Lymphonia-vesicle interactions: Vesicle adsorption, membrane fragmentation, and intermembrane protein transfer Biochemistry. 27: 4645-4655. PMID 3167007  1
1987 Newton AC, Koshland DE. Protein kinase C autophosphorylates by an intrapeptide reaction. The Journal of Biological Chemistry. 262: 10185-8. PMID 3611058  1
1987 Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD. Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry. 26: 2886-93. PMID 3111527 DOI: 10.1021/bi00384a033  1
1986 Huestis WH, Newton AC. Intermembrane protein transfer. Band 3, the erythrocyte anion transporter, transfers in native orientation from human red blood cells into the bilayer of phospholipid vesicles Journal of Biological Chemistry. 261: 16274-16278. PMID 3782118  1
1986 Newton AC, Huestis WH. Efflux of dipicolinic acid from human erythrocytes, sealed membrane fragments, and band 3-liposome complexes: A fluorescence probe for the erythrocyte anion transporter Analytical Biochemistry. 156: 56-60. PMID 3740418 DOI: 10.1016/0003-2697(86)90153-3  1
1983 Newton AC, Cook SL, Huestis WH, Ferrell JE. Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells Biochemistry. 22: 6110-6117. PMID 6661430  1
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