Robert J. DeVita - Publications

Affiliations: 
Pharmacology Icahn School of Medicine at Mount Sinai, New York, NY, United States 

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu K, Kurukulasuriya R, Dykstra K, DiMichelle L, Liu J, Vachal P, Ogawa A, DeVita RJ, Shen DM, Tan Q, Chen Y, Gauthier D, Verras A, Crespo A, Zamlynny B, et al. Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization. Bioorganic & Medicinal Chemistry Letters. PMID 31104995 DOI: 10.1016/j.bmcl.2019.04.024  0.48
2019 He S, Lai Z, Hong Q, Shang J, Reibarkh M, Kuethe JT, Liu J, Guiadeen D, Krikorian AD, Cernak TA, Dykstra KD, Sperbeck DM, Wu Z, Yu Y, Yang GX, ... ... DeVita RJ, et al. Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. Bioorganic & Medicinal Chemistry Letters. PMID 30926247 DOI: 10.1016/j.bmcl.2019.03.025  0.48
2019 Ung PM, DeVita RJ, Schlessinger A. Encounter and React: Computer-Guided Design of Covalent Inhibitors. Cell Chemical Biology. 26: 6-8. PMID 30658111 DOI: 10.1016/j.chembiol.2018.12.009  0.48
2018 Kumar K, Man-Un Ung P, Wang P, Wang H, Li H, Andrews MK, Stewart AF, Schlessinger A, DeVita RJ. Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity. European Journal of Medicinal Chemistry. 157: 1005-1016. PMID 30170319 DOI: 10.1016/j.ejmech.2018.08.007  0.48
2018 Kumar K, Wang P, Sanchez R, Swartz E, Stewart AF, DeVita RJ. Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation. Journal of Medicinal Chemistry. PMID 30059217 DOI: 10.1021/acs.jmedchem.8b00658  0.48
2018 White KM, Abreu P, Wang H, De Jesus PD, Manicassamy B, García-Sastre A, Chanda SK, DeVita RJ, Shaw ML. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. Acs Infectious Diseases. PMID 29268608 DOI: 10.1021/acsinfecdis.7b00120  0.48
2017 Cernak T, Gesmundo NJ, Dykstra K, Yu Y, Wu Z, Shi ZC, Vachal P, Sperbeck D, He S, Murphy BA, Sonatore L, Williams S, Madeira M, Verras A, Reiter M, ... ... DeVita RJ, et al. Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors. Journal of Medicinal Chemistry. PMID 28252959 DOI: 10.1021/acs.jmedchem.6b01543  0.48
2015 Kho C, Lee A, Jeong D, Oh JG, Gorski PA, Fish K, Sanchez R, DeVita RJ, Christensen G, Dahl R, Hajjar RJ. Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nature Communications. 6: 7229. PMID 26068603 DOI: 10.1038/ncomms8229  0.44
2014 He S, Hong Q, Lai Z, Yang DX, Ting PC, Kuethe JT, Cernak TA, Dykstra KD, Sperbeck DM, Wu Z, Yu Y, Yang GX, Jian T, Liu J, Guiadeen D, ... ... DeVita RJ, et al. Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety. Acs Medicinal Chemistry Letters. 5: 1082-7. PMID 25349648 DOI: 10.1021/ml5003426  0.48
2014 Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, Chang L, Bakshi RK, Dellureficio JP, Hong Q, McLaughlin M, Belyk KM, Krska SW, Makarewicz AK, Martel EJ, ... ... DeVita RJ, et al. Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain. Acs Medicinal Chemistry Letters. 5: 717-21. PMID 24944750 DOI: 10.1021/ml5001239  0.48
2014 Muise ES, Zhu Y, Verras A, Karanam BV, Gorski J, Weingarth D, Lin HV, Hwa J, Thompson JR, Hu G, Liu J, He S, DeVita RJ, Shen DM, Pinto S. Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors. Plos One. 9: e88908. PMID 24558447 DOI: 10.1371/journal.pone.0088908  0.48
2013 He S, Hong Q, Lai Z, Wu Z, Yu Y, Kim DW, Ting PC, Kuethe JT, Yang GX, Jian T, Liu J, Guiadeen D, Krikorian AD, Sperbeck DM, Sonatore LM, ... ... DeVita RJ, et al. Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety. Acs Medicinal Chemistry Letters. 4: 773-8. PMID 24900745 DOI: 10.1021/ml400168h  0.48
2013 Liu P, Hamill TG, Chioda M, Chobanian H, Fung S, Guo Y, Chang L, Bakshi R, Hong Q, Dellureficio J, Lin LS, Abbadie C, Alexander J, Jin H, Mandala S, ... ... DeVita RJ, et al. Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase. Acs Medicinal Chemistry Letters. 4: 509-13. PMID 24900701 DOI: 10.1021/ml4000996  0.48
2013 DeVita RJ, Pinto S. Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors. Journal of Medicinal Chemistry. 56: 9820-5. PMID 23919406 DOI: 10.1021/jm4007033  0.48
2013 Kassick AJ, Jiang J, Bunda J, Wilson D, Bao J, Lu H, Lin P, Ball RG, Doss GA, Tong X, Tsao KL, Wang H, Chicchi G, Karanam B, Tschirret-Guth R, ... ... DeVita RJ, et al. 2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways. Journal of Medicinal Chemistry. 56: 5940-8. PMID 23808489 DOI: 10.1021/jm400751p  0.48
2011 McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, ... ... Devita RJ, et al. The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species. Journal of Lipid Research. 52: 1150-61. PMID 21415123 DOI: 10.1194/jlr.M011049  0.48
2010 Howell KL, DeVita RJ, Garcia-Calvo M, Meurer RD, Lisnock J, Bull HG, McMasters DR, McCann ME, Mills SG. Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy. Bioorganic & Medicinal Chemistry Letters. 20: 6929-32. PMID 21030254 DOI: 10.1016/j.bmcl.2010.09.138  0.48
2010 Morriello GJ, Chicchi G, Johnson T, Mills SG, Demartino J, Kurtz M, Tsao KL, Zheng S, Tong X, Carlson E, Townson K, Wheeldon A, Boyce S, Collinson N, Rupniak N, ... Devita RJ, et al. Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor. Bioorganic & Medicinal Chemistry Letters. 20: 5925-32. PMID 20729082 DOI: 10.1016/j.bmcl.2010.07.058  0.48
2010 Bao J, Lu H, Morriello GJ, Carlson EJ, Wheeldon A, Chicchi GG, Kurtz MM, Tsao KL, Zheng S, Tong X, Mills SG, DeVita RJ. Tetrahydroindolizinone NK1 antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 2354-8. PMID 20188553 DOI: 10.1016/j.bmcl.2010.01.120  0.48
2010 Morriello GJ, Mills SG, Johnson T, Reibarkh M, Chicchi G, DeMartino J, Kurtz M, Davies P, Tsao KL, Zheng S, Tong X, Carlson E, Townson K, Tattersall FD, Wheeldon A, ... ... DeVita RJ, et al. Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 2007-12. PMID 20153964 DOI: 10.1016/j.bmcl.2010.01.065  0.48
2009 McMasters DR, Garcia-Calvo M, Maiorov V, McCann ME, Meurer RD, Bull HG, Lisnock J, Howell KL, DeVita RJ. Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening Bioorganic and Medicinal Chemistry Letters. 19: 2965-2968. PMID 19410454 DOI: 10.1016/j.bmcl.2009.04.031  0.48
2009 Jiang J, Bunda JL, Doss GA, Chicchi GG, Kurtz MM, Tsao KL, Tong X, Zheng S, Upthagrove A, Samuel K, Tschirret-Guth R, Kumar S, Wheeldon A, Carlson EJ, Hargreaves R, ... ... DeVita RJ, et al. Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 52: 3039-46. PMID 19354254 DOI: 10.1021/jm8016514  0.48
2008 Morriello GJ, Devita RJ, Mills SG, Young JR, Lin P, Doss G, Chicchi GG, Demartino J, Kurtz MM, Tsao KL, Carlson E, Townson K, Wheeldon A, Boyce S, Collinson N, et al. Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists. Bioorganic & Medicinal Chemistry. 16: 2156-70. PMID 18248994 DOI: 10.1016/j.bmc.2007.11.081  0.48
2007 Lin P, Chang L, Devita RJ, Young JR, Eid R, Tong X, Zheng S, Ball RG, Tsou NN, Chicchi GG, Kurtz MM, Tsao KL, Wheeldon A, Carlson EJ, Eng W, et al. The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine. Bioorganic & Medicinal Chemistry Letters. 17: 5191-8. PMID 17637506 DOI: 10.1016/j.bmcl.2007.06.085  0.48
2006 Jiang J, Hoang M, Young JR, Chaung D, Eid R, Turner C, Lin P, Tong X, Wang J, Tan C, Feighner S, Palyha O, Hreniuk DL, Pan J, Sailer AW, ... ... DeVita RJ, et al. 2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 5270-4. PMID 16919456 DOI: 10.1016/j.bmcl.2006.08.006  0.48
2006 Jiang J, Lin P, Hoang M, Chang L, Tan C, Feighner S, Palyha OC, Hreniuk DL, Pan J, Sailer AW, Morin NR, MacNeil DJ, Howard AD, Van der Ploeg LH, Goulet MT, ... DeVita RJ, et al. 4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 5275-9. PMID 16919453 DOI: 10.1016/j.bmcl.2006.08.008  0.48
2004 DeVita RJ, Parikh M, Jiang J, Fair JA, Young JR, Walsh TF, Goulet MT, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP, Wyvratt MJ. Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 5599-603. PMID 15482932 DOI: 10.1016/j.bmcl.2004.08.056  0.48
2004 Jiang J, DeVita RJ, Goulet MT, Wyvratt MJ, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP. Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 1795-8. PMID 15026074 DOI: 10.1016/j.bmcl.2003.12.101  0.48
2003 Jiang J, Shah H, DeVita RJ. Synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkyl-substituted azetidines. Organic Letters. 5: 4101-3. PMID 14572259 DOI: 10.1021/ol030099p  0.52
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