David Grahame Hardie - Publications

Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom 
Biochemistry, Cell Biology

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Li M, Zhang CS, Feng JW, Wei X, Zhang C, Xie C, Wu Y, Hawley SA, Atrih A, Lamont DJ, Wang Z, Piao HL, Hardie DG, Lin SC. Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1. Cell Research. PMID 33349646 DOI: 10.1038/s41422-020-00456-8  1
2020 Hawley SA, Ross FA, Russell FM, Atrih A, Lamont DJ, Hardie DG. Mechanism of Activation of AMPK by Cordycepin. Cell Chemical Biology. PMID 31991096 DOI: 10.1016/j.chembiol.2020.01.004  1
2019 Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, ... Hardie DG, et al. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research. PMID 30948787 DOI: 10.1038/S41422-019-0163-6  1
2018 Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM. Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical Journal. PMID 30135087 DOI: 10.1042/Bcj20180475  1
2018 Fyffe FA, Hawley SA, Gray A, Hardie DG. Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK. Methods in Molecular Biology (Clifton, N.J.). 1732: 69-86. PMID 29480469 DOI: 10.1007/978-1-4939-7598-3_5  1
2017 Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, ... ... Hardie DG, et al. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. PMID 28723898 DOI: 10.1038/Nature23275  1
2017 Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG. Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chemical Biology. PMID 28625738 DOI: 10.1016/j.chembiol.2017.05.021  1
2016 Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG. The Na+/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes. PMID 27381369 DOI: 10.2337/db16-0058  1
2016 Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG. AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2. Molecular Cancer Research : McR. PMID 27141100 DOI: 10.1158/1541-7786.MCR-15-0479  1
2015 Hardie DG, Schaffer BE, Brunet A. AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends in Cell Biology. PMID 26616193 DOI: 10.1016/J.Tcb.2015.10.013  1
2015 Schneider H, Schubert KM, Blodow S, Kreutz CP, Erdogmus S, Wiedenmann M, Qiu J, Fey T, Ruth P, Lubomirov LT, Pfitzer G, Mederos Y Schnitzler M, Hardie DG, Gudermann T, Pohl U. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle. Hypertension. 66: 108-16. PMID 26034200 DOI: 10.1161/HYPERTENSIONAHA.115.05514  1
2015 Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA. PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. The Biochemical Journal. 467: 461-72. PMID 25695398 DOI: 10.1042/BJ20141142  1
2015 Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 64: 360-9. PMID 25338814 DOI: 10.2337/db14-0508  1
2014 Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK. Chemistry & Biology. 21: 866-79. PMID 25036776 DOI: 10.1016/j.chembiol.2014.05.014  1
2014 Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. The Biochemical Journal. 459: 275-87. PMID 24467442 DOI: 10.1042/BJ20131344  1
2014 Hadad SM, Hardie DG, Appleyard V, Thompson AM. Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 16: 746-52. PMID 24338509 DOI: 10.1007/s12094-013-1144-8  1
2013 Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nature Medicine. 19: 1649-54. PMID 24185692 DOI: 10.1038/nm.3372  1
2013 Philp A, MacKenzie MG, Belew MY, Towler MC, Corstorphine A, Papalamprou A, Hardie DG, Baar K. Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle. Plos One. 8: e77200. PMID 24146969 DOI: 10.1371/journal.pone.0077200  1
2013 Gowans GJ, Hawley SA, Ross FA, Hardie DG. AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metabolism. 18: 556-66. PMID 24093679 DOI: 10.1016/j.cmet.2013.08.019  1
2013 Steinberg GR, Dandapani M, Hardie DG. AMPK: mediating the metabolic effects of salicylate-based drugs? Trends in Endocrinology and Metabolism: Tem. 24: 481-7. PMID 23871515 DOI: 10.1016/j.tem.2013.06.002  1
2013 Hardie DG, Alessi DR. LKB1 and AMPK and the cancer-metabolism link - ten years after. Bmc Biology. 11: 36. PMID 23587167 DOI: 10.1186/1741-7007-11-36  1
2012 Hardie DG, Ross FA, Hawley SA. AMP-activated protein kinase: a target for drugs both ancient and modern. Chemistry & Biology. 19: 1222-36. PMID 23102217 DOI: 10.1016/j.chembiol.2012.08.019  1
2012 Evans AM, Peers C, Wyatt CN, Kumar P, Hardie DG. Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. Advances in Experimental Medicine and Biology. 758: 81-90. PMID 23080146 DOI: 10.1007/978-94-007-4584-1_11  1
2012 Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. The ancient drug salicylate directly activates AMP-activated protein kinase. Science (New York, N.Y.). 336: 918-22. PMID 22517326 DOI: 10.1126/science.1215327  1
2012 Turban S, Stretton C, Drouin O, Green CJ, Watson ML, Gray A, Ross F, Lantier L, Viollet B, Hardie DG, Marette A, Hundal HS. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. The Journal of Biological Chemistry. 287: 20088-99. PMID 22511782 DOI: 10.1074/jbc.M111.330746  1
2012 Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature Reviews. Molecular Cell Biology. 13: 251-62. PMID 22436748 DOI: 10.1038/nrm3311  1
2011 Ikematsu N, Dallas ML, Ross FA, Lewis RW, Rafferty JN, David JA, Suman R, Peers C, Hardie DG, Evans AM. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability. Proceedings of the National Academy of Sciences of the United States of America. 108: 18132-7. PMID 22006306 DOI: 10.1073/Pnas.1106201108  1
2011 Hardie DG, Carling D, Gamblin SJ. AMP-activated protein kinase: also regulated by ADP? Trends in Biochemical Sciences. 36: 470-7. PMID 21782450 DOI: 10.1016/J.Tibs.2011.06.004  1
2011 Jamieson PM, Cleasby ME, Kuperman Y, Morton NM, Kelly PA, Brownstein DG, Mustard KJ, Vaughan JM, Carter RN, Hahn CN, Hardie DG, Seckl JR, Chen A, Vale WW. Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet. Diabetologia. 54: 2392-403. PMID 21667214 DOI: 10.1007/S00125-011-2205-6  1
2011 Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L, Moulder-Thompson S, Dewar JA, Thompson AM. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Research and Treatment. 128: 783-94. PMID 21655990 DOI: 10.1007/s10549-011-1612-1  1
2011 zur Nedden S, Hawley S, Pentland N, Hardie DG, Doney AS, Frenguelli BG. Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6221-34. PMID 21508245 DOI: 10.1523/JNEUROSCI.4039-10.2011  1
2011 Green CJ, Macrae K, Fogarty S, Hardie DG, Sakamoto K, Hundal HS. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase. The Biochemical Journal. 435: 463-74. PMID 21323644 DOI: 10.1042/BJ20101517  1
2011 Ross FA, Rafferty JN, Dallas ML, Ogunbayo O, Ikematsu N, McClafferty H, Tian L, Widmer H, Rowe IC, Wyatt CN, Shipston MJ, Peers C, Hardie DG, Evans AM. Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase. The Journal of Biological Chemistry. 286: 11929-36. PMID 21209098 DOI: 10.1074/Jbc.M110.189779  1
2011 Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, ... ... Hardie DG, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nature Genetics. 43: 117-20. PMID 21186350 DOI: 10.1038/Ng.735  1
2011 Evans AM, Hardie DG, Peers C, Mahmoud A. Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing. Current Opinion in Anaesthesiology. 24: 13-20. PMID 21157304 DOI: 10.1097/Aco.0B013E3283421201  1
2010 Mankouri J, Tedbury PR, Gretton S, Hughes ME, Griffin SD, Dallas ML, Green KA, Hardie DG, Peers C, Harris M. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 107: 11549-54. PMID 20534540 DOI: 10.1073/Pnas.0912426107  1
2010 Hawley SA, Ross FA, Chevtzoff C, Green KA, Evans A, Fogarty S, Towler MC, Brown LJ, Ogunbayo OA, Evans AM, Hardie DG. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metabolism. 11: 554-65. PMID 20519126 DOI: 10.1016/j.cmet.2010.04.001  1
2010 McDonald A, Fogarty S, Leclerc I, Hill EV, Hardie DG, Rutter GA. Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic β-cells: Evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement Biochemical Society Transactions. 38: 205-208. PMID 20074060 DOI: 10.1042/BST0380205  1
2010 Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: Synergistic effects of Ca2+ and AMP Biochemical Journal. 426: 109-118. PMID 19958286 DOI: 10.1042/BJ20091372  1
2010 Fogarty S, Hardie DG. Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer Biochimica Et Biophysica Acta - Proteins and Proteomics. 1804: 581-591. PMID 19778642 DOI: 10.1016/j.bbapap.2009.09.012  1
2009 McDonald A, Fogarty S, Leclerc I, Hill EV, Hardie DG, Rutter GA. Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation. Islets. 1: 198-209. PMID 21099273 DOI: 10.4161/isl.1.3.9608  1
2009 Evans AM, Hardie DG, Peers C, Wyatt CN, Viollet B, Kumar P, Dallas ML, Ross F, Ikematsu N, Jordan HL, Barr BL, Rafferty JN, Ogunbayo O. Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery. Annals of the New York Academy of Sciences. 1177: 89-100. PMID 19845611 DOI: 10.1111/J.1749-6632.2009.05041.X  1
2009 Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM. Histological evaluation of AMPK signalling in primary breast cancer. Bmc Cancer. 9: 307. PMID 19723334 DOI: 10.1186/1471-2407-9-307  1
2009 Dallas ML, Scragg JL, Wyatt CN, Ross F, Hardie DG, Evans AM, Peers C. Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase. Advances in Experimental Medicine and Biology. 648: 57-63. PMID 19536465 DOI: 10.1007/978-90-481-2259-2_6  1
2009 McBride A, Hardie DG. AMP-activated protein kinase - A sensor of glycogen as well as AMP and ATP? Acta Physiologica. 196: 99-113. PMID 19245651 DOI: 10.1111/j.1748-1716.2009.01975.x  1
2009 Fogarty S, Hardie DG. C-terminal phosphorylation of LKB1 Is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest Journal of Biological Chemistry. 284: 77-84. PMID 18854318 DOI: 10.1074/jbc.M806152200  1
2008 Towler MC, Fogarty S, Hawley SA, Pan DA, Martin DM, Morrice NA, McCarthy A, Galardo MN, Meroni SB, Cigorraga SB, Ashworth A, Sakamoto K, Hardie DG. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. The Biochemical Journal. 416: 1-14. PMID 18774945 DOI: 10.1042/BJ20081447  1
2008 Robertson TP, Mustard KJ, Lewis TH, Clark JH, Wyatt CN, Blanco EA, Peers C, Hardie DG, Evans AM. AMP-activated protein kinase and hypoxic pulmonary vasoconstriction. European Journal of Pharmacology. 595: 39-43. PMID 18703047 DOI: 10.1016/J.Ejphar.2008.07.035  1
2008 Mooney MH, Fogarty S, Stevenson C, Gallagher AM, Palit P, Hawley SA, Hardie DG, Coxon GD, Waigh RD, Tate RJ, Harvey AL, Furman BL. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. British Journal of Pharmacology. 153: 1669-77. PMID 18297106 DOI: 10.1038/bjp.2008.37  1
2008 McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. The Journal of Physiology. 586: 1731-41. PMID 18202101 DOI: 10.1113/jphysiol.2007.143685  1
2008 Wyatt CN, Pearson SA, Kumar P, Peers C, Hardie DG, Evans AM. Key roles for AMP-activated protein kinase in the function of the carotid body? Advances in Experimental Medicine and Biology. 605: 63-8. PMID 18085248 DOI: 10.1007/978-0-387-73693-8_11  1
2007 Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. The Journal of Biological Chemistry. 282: 32549-60. PMID 17855357 DOI: 10.1074/jbc.M706536200  1
2007 Geraghty KM, Chen S, Harthill JE, Ibrahim AF, Toth R, Morrice NA, Vandermoere F, Moorhead GB, Hardie DG, MacKintosh C. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. The Biochemical Journal. 407: 231-41. PMID 17617058 DOI: 10.1042/Bj20070649  1
2007 Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz P. A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits. The Journal of Biological Chemistry. 282: 16117-25. PMID 17403675 DOI: 10.1074/Jbc.M611804200  1
2007 Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI. Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metabolism. 5: 151-6. PMID 17276357 DOI: 10.1016/J.Cmet.2007.01.008  1
2007 Hardie DG, Frenguelli BG. A neural protection racket: AMPK and the GABA(B) receptor. Neuron. 53: 159-62. PMID 17224398 DOI: 10.1016/j.neuron.2007.01.004  1
2007 Wyatt CN, Mustard KJ, Pearson SA, Dallas ML, Atkinson L, Kumar P, Peers C, Hardie DG, Evans AM. AMP-activated protein kinase mediates carotid body excitation by hypoxia. The Journal of Biological Chemistry. 282: 8092-8. PMID 17179156 DOI: 10.1074/Jbc.M608742200  1
2006 Tamás P, Hawley SA, Clarke RG, Mustard KJ, Green K, Hardie DG, Cantrell DA. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. The Journal of Experimental Medicine. 203: 1665-70. PMID 16818670 DOI: 10.1084/jem.20052469  1
2006 Wyatt CN, Kumar P, Aley P, Peers C, Hardie DG, Evans AM. Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? Advances in Experimental Medicine and Biology. 580: 191-6; discussion 35. PMID 16683718 DOI: 10.1007/0-387-31311-7_29  1
2006 Evans AM, Mustard KJW, Wyatt CN, Dipp M, Kinnear NP, Hardie DG. Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction? Advances in Experimental Medicine and Biology.. 580: 147-154; discussion . PMID 16683711 DOI: 10.1007/0-387-31311-7_22  1
2006 Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase--development of the energy sensor concept. The Journal of Physiology. 574: 7-15. PMID 16644800 DOI: 10.1113/jphysiol.2006.108944  1
2005 Schrauwen-Hinderling VB, Kooi ME, Hesselink MKC, Moonen-Kornips E, Schaart G, Mustard KJ, Hardie DG, Saris WHM, Nicolay K, Schrauwen P. Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet Obesity Research. 13: 2088-2094. PMID 16421342  1
2005 Evans AM, Mustard KJ, Wyatt CN, Peers C, Dipp M, Kumar P, Kinnear NP, Hardie DG. Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells? The Journal of Biological Chemistry. 280: 41504-11. PMID 16199527 DOI: 10.1074/Jbc.M510040200  1
2005 Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism. 2: 9-19. PMID 16054095 DOI: 10.1016/J.Cmet.2005.05.009  1
2005 Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism. 1: 15-25. PMID 16054041 DOI: 10.1016/J.Cmet.2004.12.003  1
2005 Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE, Williams LM, Hawley SA, Hardie DG, Grossman AB, Korbonits M. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. The Journal of Biological Chemistry. 280: 25196-201. PMID 15899896 DOI: 10.1074/jbc.C500175200  1
2005 Prats C, Cadefau JA, Cussó R, Qvortrup K, Nielsen JN, Wojtaszewki JFP, Hardie DG, Stewart G, Hansen BF, Ploug T. Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis Journal of Biological Chemistry. 280: 23165-23172. PMID 15840572 DOI: 10.1074/jbc.M502713200  1
2005 Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 288: E599-607. PMID 15562249 DOI: 10.1152/Ajpendo.00439.2004  1
2004 Jørgensen SB, Nielsen JN, Birk JB, Olsen GS, Viollet B, Andreelli F, Schjerling P, Vaulont S, Hardie DG, Hansen BF, Richter EA, Wojtaszewski JFP. The α2-5′ AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading Diabetes. 53: 3074-3081. PMID 15561936 DOI: 10.2337/diabetes.53.12.3074  1
2004 Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. Analysis of the LKB1-STRAD-MO25 complex. Journal of Cell Science. 117: 6365-75. PMID 15561763 DOI: 10.1242/Jcs.01571  1
2004 Kelner A, Pekala I, Kaczanowski S, Muszynska G, Hardie DG, Dobrowolska G. Biochemical characterization of the tobacco 42-kD protein kinase activated by osmotic stress. Plant Physiology. 136: 3255-65. PMID 15466234 DOI: 10.1104/pp.104.046151  1
2004 Roepstorff C, Vistisen B, Donsmark M, Nielsen JN, Galbo H, Green KA, Hardie DG, Wojtaszewski JFP, Richter EA, Kiens B. Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise Journal of Physiology. 560: 551-562. PMID 15308678 DOI: 10.1113/jphysiol.2004.066480  1
2004 Slocombe SP, Beaudoin F, Donaghy PG, Hardie DG, Dickinson JR, Halford NG. SNF1-related protein kinase (snRK1) phosphorylates class I heat shock protein. Plant Physiology and Biochemistry : Ppb / Sociã©Tã© Franã§Aise De Physiologie Vã©Gã©Tale. 42: 111-6. PMID 15283126 DOI: 10.1016/j.plaphy.2003.11.009  1
2004 Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proceedings of the National Academy of Sciences of the United States of America. 101: 6409-14. PMID 15096593 DOI: 10.1073/Pnas.0401627101  1
2004 Sakamoto K, Göransson O, Hardie DG, Alessi DR. Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR American Journal of Physiology - Endocrinology and Metabolism. 287: E310-E317. PMID 15068958 DOI: 10.1152/Ajpendo.00074.2004  1
2004 Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, Frenguelli BG. AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Journal of Neurochemistry. 88: 1272-82. PMID 15009683 DOI: 10.1046/J.1471-4159.2003.02253.X  1
2004 Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 Embo Journal. 23: 833-843. PMID 14976552 DOI: 10.1038/Sj.Emboj.7600110  1
2004 Scott JW, Hawley SA, Green KA, Anis M, Stewart G, Scullion GA, Norman DG, Hardie DG. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. The Journal of Clinical Investigation. 113: 274-84. PMID 14722619 DOI: 10.1172/JCI19874  1
2003 Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Journal of Biology. 2: 28. PMID 14511394 DOI: 10.1186/1475-4924-2-28  1
2003 Coven DL, Hu X, Cong L, Bergeron R, Shulman GI, Hardie DG, Young LH. Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise. American Journal of Physiology. Endocrinology and Metabolism. 285: E629-36. PMID 12759223 DOI: 10.1152/Ajpendo.00171.2003  1
2003 Winder WW, Hardie DG, Mustard KJ, Greenwood LJ, Paxton BE, Park SH, Rubink DS, Taylor EB. Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle. Biochemical Society Transactions. 31: 182-5. PMID 12546681 DOI: 10.1042/Bst0310182  1
2003 Nielsen JN, Mustard KJW, Graham DA, Yu H, MacDonald CS, Pilegaard H, Goodyear LJ, Hardie DG, Richter EA, Wojtaszewski JFP. 5′-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle Journal of Applied Physiology. 94: 631-641. PMID 12391032 DOI: 10.1152/JAPPLPHYSIOL.00642.2002  1
2002 Wang W, Fan J, Yang X, Fürer-Galban S, Lopez de Silanes I, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe M. AMP-activated kinase regulates cytoplasmic HuR. Molecular and Cellular Biology. 22: 3425-36. PMID 11971974 DOI: 10.1128/Mcb.22.10.3425-3436.2002  1
2002 Downs SM, Hudson ER, Hardie DG. A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Developmental Biology. 245: 200-12. PMID 11969266 DOI: 10.1006/Dbio.2002.0613  1
2002 Scott JW, Norman DG, Hawley SA, Kontogiannis L, Hardie DG. Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate. Journal of Molecular Biology. 317: 309-23. PMID 11902845 DOI: 10.1006/jmbi.2001.5316  1
2000 Fryer LG, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, Carling D. Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes. 49: 1978-85. PMID 11117997 DOI: 10.2337/Diabetes.49.12.1978  1
2000 Lochhead PA, Salt IP, Walker KS, Hardie DG, Sutherland C. 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6- phosphatase Diabetes. 49: 896-903. PMID 10866040 DOI: 10.2337/DIABETES.49.6.896  1
2000 da Silva Xavier G, Leclerc I, Salt IP, Doiron B, Hardie DG, Kahn A, Rutter GA. Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proceedings of the National Academy of Sciences of the United States of America. 97: 4023-8. PMID 10760274 DOI: 10.1073/pnas.97.8.4023  1
2000 Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. The Biochemical Journal. 346: 659-69. PMID 10698692 DOI: 10.1042/Bj3460659  1
1999 Smith FC, Davies SP, Wilson WA, Carling D, Hardie DG. The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. Febs Letters. 453: 219-23. PMID 10403407 DOI: 10.1016/S0014-5793(99)00725-5  1
1998 Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annual Review of Biochemistry. 67: 821-55. PMID 9759505 DOI: 10.1146/Annurev.Biochem.67.1.821  1
1998 Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. The Biochemical Journal. 334: 177-87. PMID 9693118 DOI: 10.1042/Bj3340177  1
1998 Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. The Embo Journal. 17: 1688-99. PMID 9501090 DOI: 10.1093/Emboj/17.6.1688  1
1997 Hardie DG, Carling D. The AMP-activated protein kinase--fuel gauge of the mammalian cell? European Journal of Biochemistry / Febs. 246: 259-73. PMID 9208914 DOI: 10.1111/J.1432-1033.1997.00259.X  1
1997 Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW. Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase. Febs Letters. 403: 254-8. PMID 9091312 DOI: 10.1016/S0014-5793(97)00062-8  1
1997 Winder WW, Wilson HA, Hardie DG, Rasmussen BB, Hutber CA, Call GB, Clayton RD, Conley LM, Yoon S, Zhou B. Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. Journal of Applied Physiology (Bethesda, Md. : 1985). 82: 219-25. PMID 9029219 DOI: 10.1152/Jappl.1997.82.1.219  1
1996 Woods A, Salt I, Scott J, Hardie DG, Carling D. The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. Febs Letters. 397: 347-51. PMID 8955377 DOI: 10.1016/S0014-5793(96)01209-4  1
1996 Barker JHA, Slocombe SP, Ball KL, Hardie DG, Shewry PR, Halford NG. Evidence that barley 3-hydroxy-3-methylglutaryl-coenzyme a reductase kinase is a member of the sucrose nonfermenting-1-related protein kinase family Plant Physiology. 112: 1141-1149. PMID 8938414 DOI: 10.1104/pp.112.3.1141  1
1996 Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. The Journal of Biological Chemistry. 271: 27879-87. PMID 8910387 DOI: 10.1074/Jbc.271.44.27879  1
1995 Verhoeven AJ, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D. The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. European Journal of Biochemistry / Febs. 228: 236-43. PMID 7705334 DOI: 10.1111/J.1432-1033.1995.Tb20255.X  1
1995 Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. The Journal of Biological Chemistry. 270: 27186-91. PMID 7592975 DOI: 10.1074/Jbc.270.45.27186  1
1994 Davies SP, Hawley SA, Woods A, Carling D, Haystead TA, Hardie DG. Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. European Journal of Biochemistry / Febs. 223: 351-7. PMID 8055903 DOI: 10.1111/J.1432-1033.1994.Tb19001.X  1
1992 Davies SP, Carling D, Munday MR, Hardie DG. Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. European Journal of Biochemistry / Febs. 203: 615-23. PMID 1346520 DOI: 10.1111/J.1432-1033.1992.Tb16591.X  1
1991 Carling D, Clarke PR, Hardie DG. Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase. Methods in Enzymology. 200: 362-71. PMID 1683469 DOI: 10.1016/0076-6879(91)00153-N  1
1991 Hardie DG, Haystead TAJ, Sim ATR. Use of okadaic acid to inhibit protein phosphatases in intact cells Methods in Enzymology. 201: 469-476. PMID 1658560 DOI: 10.1016/0076-6879(91)01042-Z  1
1990 Haystead TAJ, Moore F, Cohen P, Hardie DG. Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes European Journal of Biochemistry. 187: 199-205. PMID 1688796 DOI: 10.1111/J.1432-1033.1990.Tb15295.X  1
1989 Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. European Journal of Biochemistry / Febs. 186: 129-36. PMID 2598924 DOI: 10.1111/J.1432-1033.1989.Tb15186.X  1
1989 Davies SP, Carling D, Hardie DG. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. European Journal of Biochemistry / Febs. 186: 123-8. PMID 2574667 DOI: 10.1111/J.1432-1033.1989.Tb15185.X  1
1989 Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337: 78-81. PMID 2562908 DOI: 10.1038/337078A0  1
1989 Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. European Journal of Biochemistry / Febs. 179: 249-54. PMID 2537200 DOI: 10.1111/J.1432-1033.1989.Tb14548.X  1
1988 Munday MR, Carling D, Hardie DG. Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. Febs Letters. 235: 144-8. PMID 2900158 DOI: 10.1016/0014-5793(88)81251-1  1
1988 Haystead TAJ, Campbell DG, Hardie DG. Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase European Journal of Biochemistry. 175: 347-354. PMID 2900140 DOI: 10.1111/J.1432-1033.1988.Tb14203.X  1
1988 Haystead TAJ, Hardie DG. Insulin and phorbol ester stimulate phosphorylation of acety-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C European Journal of Biochemistry. 175: 339-345. PMID 2900139 DOI: 10.1111/J.1432-1033.1988.Tb14202.X  1
1988 Munday MR, Campbell DG, Carling D, Hardie DG. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. European Journal of Biochemistry / Febs. 175: 331-8. PMID 2900138 DOI: 10.1111/J.1432-1033.1988.Tb14201.X  1
1987 Jones SMA, Sim ATR, Hardie DG, Yeaman SJ. Phosphorylation of branched-chain 2-oxo acid dehydrogenase complex in isolated hepatocytes Biochemical and Biophysical Research Communications. 144: 628-633. PMID 3579934 DOI: 10.1016/S0006-291X(87)80012-8  1
1987 Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. Febs Letters. 223: 217-22. PMID 2889619 DOI: 10.1016/0014-5793(87)80292-2  1
1986 Hardie DG, McCarthy AD, Braddock M. Mammalian fatty acid synthase: a chimeric protein which has evolved by gene fusion. Biochemical Society Transactions. 14: 568-70. PMID 3732595 DOI: 10.1042/BST0140568  1
1986 Haystead TAJ, Hardie DG. Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-M(r) effector and not by increased phosphorylation Biochemical Journal. 240: 99-106. PMID 2881538 DOI: 10.1042/Bj2400099  1
1986 Munday MR, Haystead TA, Holland R, Carling DA, Hardie DG. The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. Biochemical Society Transactions. 14: 559-62. PMID 2874088  1
1986 Hardie DG, Carling D, Ferrari S, Guy PS, Aitken A. Characterization of the phosphorylation of rat mammary ATP-citrate lyase and acetyl-CoA carboxylase by Ca2+ and calmodulin-dependent multiprotein kinase and Ca2+ and phospholipid-dependent protein kinase. European Journal of Biochemistry / Febs. 157: 553-61. PMID 2873035 DOI: 10.1111/J.1432-1033.1986.Tb09702.X  1
1986 Haystead TAJ, Hardie DG. Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay Biochemical Journal. 234: 279-284. PMID 2872882 DOI: 10.1042/Bj2340279  1
1986 Carling D, Hardie DG. Isolation of a cyclic-AMP-independent protein kinase from rat liver and its effect on the enzymic activity of acetyl-CoA carboxylase Biochemical Society Transactions. 14: 1076-1077. DOI: 10.1042/Bst0141076  1
1985 Hardie DG, Dewart KB, Aitken A, McCarthy AD. Amino acid sequence around the reactive serine residue of the thioesterase domain of rabbit fatty acid synthase. Biochimica Et Biophysica Acta. 828: 380-2. PMID 3921056 DOI: 10.1016/0167-4838(85)90320-6  1
1985 Hardie DG, McCarthy AD. Fatty acid synthase: probing the structure of a multifunctional protein by limited proteolysis. Biochemical Society Transactions. 13: 297-9. PMID 3894109 DOI: 10.1042/BST0130297  1
1985 Vulliet PR, Woodgett JR, Ferrari S, Hardie DG. Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid-dependent protein kinase, calmodulin-dependent multiprotein kinase and cyclic AMP-dependent protein kinase. Febs Letters. 182: 335-9. PMID 2858405 DOI: 10.1016/0014-5793(85)80328-8  1
1984 McCarthy AD, Hardie DG. Fatty acid synthase - an example of protein evolution by gene fusion Trends in Biochemical Sciences. 9: 60-63. DOI: 10.1016/0968-0004(84)90184-1  1
1983 McCarthy AD, Hardie DG. The multifunctional polypeptide chains of rabbit-mammary fatty-acid synthase. Stoichiometry of active sites and active-site mapping using limited proteolysis. European Journal of Biochemistry / Febs. 130: 185-93. PMID 6549986 DOI: 10.1111/J.1432-1033.1983.TB07135.X  1
1983 McCarthy AD, Aitken A, Hardie DG. The multifunctional polypeptide chain of rabbit mammary fatty acid synthase contains a domain homologous with the acyl carrier protein of Escherichia coli. European Journal of Biochemistry / Febs. 136: 501-8. PMID 6357793 DOI: 10.1111/J.1432-1033.1983.TB07769.X  1
1983 Holland R, Woodgett JR, Hardie DG. Evidence that amiloride antagonises insulin-stimulated protein phosphorylation by inhibiting protein kinase activity Febs Letters. 154: 269-273. PMID 6299802 DOI: 10.1016/0014-5793(83)80163-X  1
1982 McCarthy AD, Hardie DG. Reaction of chloroacetyl-CoA with rabbit fatty acid synthase. A new method to label specifically and quantify pantetheine prosthetic groups. Febs Letters. 147: 256-60. PMID 7173396 DOI: 10.1016/0014-5793(82)81054-5  1
1976 Hardie DG, Manners DJ, Yellowlees D. The limit dextrinase from malted sorghum (Sorghum vulgare). Carbohydrate Research. 50: 75-85. PMID 975121 DOI: 10.1016/S0008-6215(00)84084-7  1
1974 Hardie DG, Manners DJ. A viscometric assay for pullulanase-type, debranching enzymes. Carbohydrate Research. 36: 207-10. PMID 4471984 DOI: 10.1016/S0008-6215(00)82010-8  1
1973 Dunn G, Hardie DG, Manners DJ. Observations of the action of limit dextrinases on amylopectin-like polysaccharides. The Biochemical Journal. 133: 413-6. PMID 4734116  1
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