David Grahame Hardie - Publications

Affiliations: 
Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom 
Area:
Biochemistry, Cell Biology
Website:
https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216540701556873

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hawley SA, Russell FM, Ross FA, Hardie DG. BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. International Journal of Molecular Sciences. 25. PMID 38203624 DOI: 10.3390/ijms25010453  0.343
2022 Hardie DG. AMP-activated protein kinase - a journey from 1 to 100 downstream targets. The Biochemical Journal. 479: 2327-2343. PMID 36383046 DOI: 10.1042/BCJ20220255  0.345
2018 Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM. Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical Journal. PMID 30135087 DOI: 10.1042/Bcj20180475  0.306
2018 Fyffe FA, Hawley SA, Gray A, Hardie DG. Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK. Methods in Molecular Biology (Clifton, N.J.). 1732: 69-86. PMID 29480469 DOI: 10.1007/978-1-4939-7598-3_5  0.315
2017 Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, et al. CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation. Molecular Cell. 68: 336-349.e6. PMID 29053957 DOI: 10.1016/j.molcel.2017.09.034  0.323
2017 Hardie DG, Lin SC. AMP-activated protein kinase - not just an energy sensor. F1000research. 6: 1724. PMID 29034085 DOI: 10.12688/F1000Research.11960.1  0.308
2017 Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG. Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chemical Biology. PMID 28625738 DOI: 10.1016/j.chembiol.2017.05.021  0.348
2016 Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG. The Na+/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes. PMID 27381369 DOI: 10.2337/db16-0058  0.3
2014 Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. The Biochemical Journal. 459: 275-87. PMID 24467442 DOI: 10.1042/BJ20131344  0.328
2013 Gowans GJ, Hawley SA, Ross FA, Hardie DG. AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metabolism. 18: 556-66. PMID 24093679 DOI: 10.1016/j.cmet.2013.08.019  0.366
2012 Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. The ancient drug salicylate directly activates AMP-activated protein kinase. Science (New York, N.Y.). 336: 918-22. PMID 22517326 DOI: 10.1126/science.1215327  0.322
2010 Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: Synergistic effects of Ca2+ and AMP Biochemical Journal. 426: 109-118. PMID 19958286 DOI: 10.1042/BJ20091372  0.339
2009 McBride A, Hardie DG. AMP-activated protein kinase - A sensor of glycogen as well as AMP and ATP? Acta Physiologica. 196: 99-113. PMID 19245651 DOI: 10.1111/j.1748-1716.2009.01975.x  0.322
2009 Fogarty S, Hardie DG. C-terminal phosphorylation of LKB1 Is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest Journal of Biological Chemistry. 284: 77-84. PMID 18854318 DOI: 10.1074/jbc.M806152200  0.362
2007 Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. The Journal of Biological Chemistry. 282: 32549-60. PMID 17855357 DOI: 10.1074/jbc.M706536200  0.362
2007 Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Reviews. Molecular Cell Biology. 8: 774-85. PMID 17712357 DOI: 10.1038/nrm2249  0.303
2007 Geraghty KM, Chen S, Harthill JE, Ibrahim AF, Toth R, Morrice NA, Vandermoere F, Moorhead GB, Hardie DG, MacKintosh C. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. The Biochemical Journal. 407: 231-41. PMID 17617058 DOI: 10.1042/Bj20070649  0.336
2007 Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circulation Research. 100: 328-41. PMID 17307971 DOI: 10.1161/01.RES.0000256090.42690.05  0.356
2007 Scott JW, Ross FA, Liu JK, Hardie DG. Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. The Embo Journal. 26: 806-15. PMID 17255938 DOI: 10.1038/sj.emboj.7601542  0.318
2006 Evans AM, Mustard KJW, Wyatt CN, Dipp M, Kinnear NP, Hardie DG. Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction? Advances in Experimental Medicine and Biology.. 580: 147-154; discussion . PMID 16683711 DOI: 10.1007/0-387-31311-7_22  0.304
2005 Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism. 2: 9-19. PMID 16054095 DOI: 10.1016/J.Cmet.2005.05.009  0.349
2005 Hardie DG. New roles for the LKB1-->AMPK pathway. Current Opinion in Cell Biology. 17: 167-73. PMID 15780593 DOI: 10.1016/J.CEB.2005.01.006  0.327
2005 Hardie DG. The AMP-activated protein kinase pathway--new players upstream and downstream. Journal of Cell Science. 117: 5479-87. PMID 15509864 DOI: 10.1242/jcs.01540  0.334
2005 Kopecky J, Brauner P, Matejkova O, Mustard K, Flachs P, Thomason-Hughes M, Rossmeisl M, Hardie D. W08-P-012 Possible involvement of AMP-activated protein kinase in adipocytes in regulation of adiposity Atherosclerosis Supplements. 6: 32-33. DOI: 10.1016/S1567-5688(05)80128-X  0.335
2004 Kelner A, Pekala I, Kaczanowski S, Muszynska G, Hardie DG, Dobrowolska G. Biochemical characterization of the tobacco 42-kD protein kinase activated by osmotic stress. Plant Physiology. 136: 3255-65. PMID 15466234 DOI: 10.1104/pp.104.046151  0.372
2004 Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proceedings of the National Academy of Sciences of the United States of America. 101: 6409-14. PMID 15096593 DOI: 10.1073/Pnas.0401627101  0.33
2004 Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 Embo Journal. 23: 833-843. PMID 14976552 DOI: 10.1038/Sj.Emboj.7600110  0.337
2003 Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Journal of Biology. 2: 28. PMID 14511394 DOI: 10.1186/1475-4924-2-28  0.311
2003 Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology. 144: 5179-83. PMID 12960015 DOI: 10.1210/EN.2003-0982  0.308
2003 Sutherland CM, Hawley SA, McCartney RR, Leech A, Stark MJ, Schmidt MC, Hardie DG. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Current Biology : Cb. 13: 1299-305. PMID 12906789 DOI: 10.1016/S0960-9822(03)00459-7  0.341
2003 Hardie DG, Scott JW, Pan DA, Hudson ER. Management of cellular energy by the AMP-activated protein kinase system. Febs Letters. 546: 113-20. PMID 12829246  0.35
2003 Hardie DG, Pan DA. Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochemical Society Transactions. 30: 1064-70. PMID 12440973 DOI: 10.1042/BST0301064  0.378
2002 Pan DA, Hardie DG. A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. The Biochemical Journal. 367: 179-86. PMID 12093363 DOI: 10.1042/BJ20020703  0.354
2002 Barnes K, Ingram JC, Porras OH, Barros LF, Hudson ER, Fryer LG, Foufelle F, Carling D, Hardie DG, Baldwin SA. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). Journal of Cell Science. 115: 2433-42. PMID 12006627  0.331
2002 Downs SM, Hudson ER, Hardie DG. A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Developmental Biology. 245: 200-12. PMID 11969266 DOI: 10.1006/Dbio.2002.0613  0.348
2002 Scott JW, Norman DG, Hawley SA, Kontogiannis L, Hardie DG. Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate. Journal of Molecular Biology. 317: 309-23. PMID 11902845 DOI: 10.1006/jmbi.2001.5316  0.33
2002 Hardie D. Regulation of fatty acid synthesis and degradation by the AMP-activated protein kinase Biochemical Society Transactions. 30: A102-A102. DOI: 10.1042/BST030A102  0.36
2000 da Silva Xavier G, Leclerc I, Salt IP, Doiron B, Hardie DG, Kahn A, Rutter GA. Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proceedings of the National Academy of Sciences of the United States of America. 97: 4023-8. PMID 10760274 DOI: 10.1073/pnas.97.8.4023  0.323
1999 Sugden C, Crawford RM, Halford NG, Hardie DG. Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP. The Plant Journal : For Cell and Molecular Biology. 19: 433-9. PMID 10504565 DOI: 10.1046/J.1365-313X.1999.00532.X  0.342
1999 Smith FC, Davies SP, Wilson WA, Carling D, Hardie DG. The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. Febs Letters. 453: 219-23. PMID 10403407 DOI: 10.1016/S0014-5793(99)00725-5  0.317
1999 Sugden C, Donaghy PG, Halford NG, Hardie DG. Two SNF1-related protein kinases from spinach leaf phosphorylate and inactivate 3-hydroxy-3-methylglutaryl-coenzyme A reductase, nitrate reductase, and sucrose phosphate synthase in vitro. Plant Physiology. 120: 257-74. PMID 10318703 DOI: 10.1104/PP.120.1.257  0.388
1999 Dyck JR, Kudo N, Barr AJ, Davies SP, Hardie DG, Lopaschuk GD. Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase. European Journal of Biochemistry. 262: 184-90. PMID 10231380 DOI: 10.1046/j.1432-1327.1999.00371.x  0.343
1999 HARDIE DG, SALT IP, HAWLEY SA, DAVIES SP. AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge Biochemical Journal. 338: 717-722. DOI: 10.1042/BJ3380717  0.33
1998 Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annual Review of Biochemistry. 67: 821-55. PMID 9759505 DOI: 10.1146/Annurev.Biochem.67.1.821  0.369
1998 Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. The Embo Journal. 17: 1688-99. PMID 9501090 DOI: 10.1093/Emboj/17.6.1688  0.321
1997 Hardie DG, Carling D. The AMP-activated protein kinase--fuel gauge of the mammalian cell? European Journal of Biochemistry / Febs. 246: 259-73. PMID 9208914 DOI: 10.1111/J.1432-1033.1997.00259.X  0.427
1997 Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW. Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase. Febs Letters. 403: 254-8. PMID 9091312 DOI: 10.1016/S0014-5793(97)00062-8  0.342
1997 Winder WW, Wilson HA, Hardie DG, Rasmussen BB, Hutber CA, Call GB, Clayton RD, Conley LM, Yoon S, Zhou B. Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. Journal of Applied Physiology (Bethesda, Md. : 1985). 82: 219-25. PMID 9029219 DOI: 10.1152/Jappl.1997.82.1.219  0.381
1996 Barker JHA, Slocombe SP, Ball KL, Hardie DG, Shewry PR, Halford NG. Evidence that barley 3-hydroxy-3-methylglutaryl-coenzyme a reductase kinase is a member of the sucrose nonfermenting-1-related protein kinase family Plant Physiology. 112: 1141-1149. PMID 8938414 DOI: 10.1104/pp.112.3.1141  0.314
1996 Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. The Journal of Biological Chemistry. 271: 27879-87. PMID 8910387 DOI: 10.1074/Jbc.271.44.27879  0.358
1996 Winder WW, Hardie DG. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. The American Journal of Physiology. 270: E299-304. PMID 8779952 DOI: 10.1152/AJPENDO.1996.270.2.E299  0.313
1996 Ching YP, Davies SP, Hardie DG. Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method. European Journal of Biochemistry. 237: 800-8. PMID 8647128 DOI: 10.1111/J.1432-1033.1996.0800P.X  0.315
1996 Davies SP, Helps NR, Cohen PT, Hardie DG. 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC. Febs Letters. 377: 421-5. PMID 8549768 DOI: 10.1016/0014-5793(95)01368-7  0.316
1996 Ball KL, Barker J, Halford NG, Hardie DG. Immunological evidence that HMG-CoA reductase kinase-A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinases. Febs Letters. 377: 189-92. PMID 8543048 DOI: 10.1016/0014-5793(95)01343-1  0.321
1995 Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? European Journal of Biochemistry. 229: 558-65. PMID 7744080 DOI: 10.1111/J.1432-1033.1995.TB20498.X  0.356
1995 Dale S, Wilson WA, Edelman AM, Hardie DG. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I. Febs Letters. 361: 191-5. PMID 7698321 DOI: 10.1016/0014-5793(95)00172-6  0.349
1995 Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. The Journal of Biological Chemistry. 270: 27186-91. PMID 7592975 DOI: 10.1074/Jbc.270.45.27186  0.332
1995 Dale S, Arró M, Becerra B, Morrice NG, Boronat A, Hardie DG, Ferrer A. Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinase. European Journal of Biochemistry. 233: 506-13. PMID 7588795 DOI: 10.1111/J.1432-1033.1995.506_2.X  0.367
1995 Hardie DG, MacKintosh RW. AMP-activated protein kinase--an archetypal protein kinase cascade? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 14: 699-704. PMID 1365882 DOI: 10.1002/BIES.950141011  0.382
1994 Weekes J, Hawley SA, Corton J, Shugar D, Hardie DG. Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues. European Journal of Biochemistry. 219: 751-7. PMID 8112325 DOI: 10.1111/J.1432-1033.1994.TB18554.X  0.35
1994 Ball KL, Dale S, Weekes J, Hardie DG. Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia). European Journal of Biochemistry. 219: 743-50. PMID 8112324 DOI: 10.1111/J.1432-1033.1994.TB18553.X  0.323
1994 Davies SP, Hawley SA, Woods A, Carling D, Haystead TA, Hardie DG. Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. European Journal of Biochemistry / Febs. 223: 351-7. PMID 8055903 DOI: 10.1111/J.1432-1033.1994.Tb19001.X  0.552
1994 Corton JM, Gillespie JG, Hardie DG. Role of the AMP-activated protein kinase in the cellular stress response. Current Biology : Cb. 4: 315-24. PMID 7922340 DOI: 10.1016/S0960-9822(00)00070-1  0.373
1992 Gillespie JG, Hardie DG. Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes. Febs Letters. 306: 59-62. PMID 1628744 DOI: 10.1016/0014-5793(92)80837-7  0.382
1992 Hardie DG. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. Biochimica Et Biophysica Acta. 1123: 231-8. PMID 1536860 DOI: 10.1016/0005-2760(92)90001-C  0.331
1992 Mackintosh RW, Davies SP, Clarke PR, Weekes J, Gillespie JG, Gibb BJ, Hardie DG. Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase. European Journal of Biochemistry. 209: 923-31. PMID 1358611 DOI: 10.1111/J.1432-1033.1992.TB17364.X  0.354
1992 Davies SP, Carling D, Munday MR, Hardie DG. Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. European Journal of Biochemistry / Febs. 203: 615-23. PMID 1346520 DOI: 10.1111/J.1432-1033.1992.Tb16591.X  0.412
1992 Corton JM, Hardie DG. Evidence against a role for phosphorylation/dephosphorylation in the regulation of acyl-CoA:cholesterol acyl transferase. European Journal of Biochemistry. 204: 203-8. PMID 1310941 DOI: 10.1111/J.1432-1033.1992.TB16625.X  0.325
1991 Carling D, Clarke PR, Hardie DG. Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase. Methods in Enzymology. 200: 362-71. PMID 1683469 DOI: 10.1016/0076-6879(91)00153-N  0.353
1991 Moore F, Weekes J, Hardie DG. Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion. European Journal of Biochemistry. 199: 691-7. PMID 1678349 DOI: 10.1111/J.1432-1033.1991.TB16172.X  0.396
1991 Cohen P, Hardie DG. The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase. Biochimica Et Biophysica Acta. 1094: 292-9. PMID 1655040 DOI: 10.1016/0167-4889(91)90089-G  0.421
1990 Hardie DG. Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase. Progress in Lipid Research. 28: 117-46. PMID 2575259 DOI: 10.1016/0163-7827(89)90010-6  0.301
1990 Denis-Duphil M, Lecaer JP, Hardie DG, Carrey EA. Yeast carbamoyl-phosphate-synthetase--aspartate-transcarbamylase multidomain protein is phosphorylated in vitro by cAMP-dependent protein kinase. European Journal of Biochemistry. 193: 581-7. PMID 1977585 DOI: 10.1111/J.1432-1033.1990.TB19376.X  0.369
1990 Davies SP, Sim AT, Hardie DG. Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase. European Journal of Biochemistry. 187: 183-90. PMID 1967580 DOI: 10.1111/J.1432-1033.1990.TB15293.X  0.369
1990 Haystead TAJ, Moore F, Cohen P, Hardie DG. Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes European Journal of Biochemistry. 187: 199-205. PMID 1688796 DOI: 10.1111/J.1432-1033.1990.Tb15295.X  0.396
1990 Clarke PR, Hardie DG. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. The Embo Journal. 9: 2439-2446. DOI: 10.1002/j.1460-2075.1990.tb07420.x  0.327
1989 Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. European Journal of Biochemistry / Febs. 186: 129-36. PMID 2598924 DOI: 10.1111/J.1432-1033.1989.Tb15186.X  0.402
1989 Davies SP, Carling D, Hardie DG. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. European Journal of Biochemistry / Febs. 186: 123-8. PMID 2574667 DOI: 10.1111/J.1432-1033.1989.Tb15185.X  0.325
1989 Carling D, Hardie DG. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochimica Et Biophysica Acta. 1012: 81-6. PMID 2567185 DOI: 10.1016/0167-4889(89)90014-1  0.375
1989 Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337: 78-81. PMID 2562908 DOI: 10.1038/337078A0  0.558
1989 Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. European Journal of Biochemistry / Febs. 179: 249-54. PMID 2537200 DOI: 10.1111/J.1432-1033.1989.Tb14548.X  0.363
1988 Munday MR, Carling D, Hardie DG. Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. Febs Letters. 235: 144-8. PMID 2900158 DOI: 10.1016/0014-5793(88)81251-1  0.338
1988 Haystead TAJ, Campbell DG, Hardie DG. Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase European Journal of Biochemistry. 175: 347-354. PMID 2900140 DOI: 10.1111/J.1432-1033.1988.Tb14203.X  0.305
1988 Haystead TAJ, Hardie DG. Insulin and phorbol ester stimulate phosphorylation of acety-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C European Journal of Biochemistry. 175: 339-345. PMID 2900139 DOI: 10.1111/J.1432-1033.1988.Tb14202.X  0.312
1988 Munday MR, Campbell DG, Carling D, Hardie DG. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. European Journal of Biochemistry / Febs. 175: 331-8. PMID 2900138 DOI: 10.1111/J.1432-1033.1988.Tb14201.X  0.39
1988 Sim AT, Hardie DG. The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase. Febs Letters. 233: 294-8. PMID 2898386 DOI: 10.1016/0014-5793(88)80445-9  0.383
1987 Jones SMA, Sim ATR, Hardie DG, Yeaman SJ. Phosphorylation of branched-chain 2-oxo acid dehydrogenase complex in isolated hepatocytes Biochemical and Biophysical Research Communications. 144: 628-633. PMID 3579934 DOI: 10.1016/S0006-291X(87)80012-8  0.308
1987 Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. Febs Letters. 223: 217-22. PMID 2889619 DOI: 10.1016/0014-5793(87)80292-2  0.417
1986 Shenolikar S, Lickteig R, Hardie DG, Soderling TR, Hanley RM, Kelly PT. Calmodulin-dependent multifunctional protein kinase. Evidence for isoenzyme forms in mammalian tissues. European Journal of Biochemistry / Febs. 161: 739-47. PMID 3539597 DOI: 10.1111/j.1432-1033.1986.tb10502.x  0.334
1986 Haystead TAJ, Hardie DG. Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-M(r) effector and not by increased phosphorylation Biochemical Journal. 240: 99-106. PMID 2881538 DOI: 10.1042/Bj2400099  0.341
1986 Munday MR, Haystead TA, Holland R, Carling DA, Hardie DG. The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. Biochemical Society Transactions. 14: 559-62. PMID 2874088  0.537
1986 Hardie DG, Carling D, Ferrari S, Guy PS, Aitken A. Characterization of the phosphorylation of rat mammary ATP-citrate lyase and acetyl-CoA carboxylase by Ca2+ and calmodulin-dependent multiprotein kinase and Ca2+ and phospholipid-dependent protein kinase. European Journal of Biochemistry / Febs. 157: 553-61. PMID 2873035 DOI: 10.1111/J.1432-1033.1986.Tb09702.X  0.38
1986 Carling D, Hardie DG. Isolation of a cyclic-AMP-independent protein kinase from rat liver and its effect on the enzymic activity of acetyl-CoA carboxylase Biochemical Society Transactions. 14: 1076-1077. DOI: 10.1042/Bst0141076  0.342
1985 Vulliet PR, Woodgett JR, Ferrari S, Hardie DG. Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid-dependent protein kinase, calmodulin-dependent multiprotein kinase and cyclic AMP-dependent protein kinase. Febs Letters. 182: 335-9. PMID 2858405 DOI: 10.1016/0014-5793(85)80328-8  0.33
1985 Holland R, Hardie DG, Clegg RA, Zammit VA. Evidence that glucagon-mediated inhibition of acetyl-CoA carboxylase in isolated adipocytes involves increased phosphorylation of the enzyme by cyclic AMP-dependent protein kinase. The Biochemical Journal. 226: 139-45. PMID 2858203 DOI: 10.1042/BJ2260139  0.421
1985 Holland R, Hardie DG. Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl-CoA carboxylase and ATP-citrate lyase in isolated hepatocytes. Febs Letters. 181: 308-12. PMID 2857659 DOI: 10.1016/0014-5793(85)80282-9  0.309
1985 Carrey E, Campbell D, Hardie D. Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. The Embo Journal. 4: 3735-3742. DOI: 10.1002/j.1460-2075.1985.tb04142.x  0.362
1984 Munday MR, Hardie DG. Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity. European Journal of Biochemistry. 141: 617-27. PMID 6146523 DOI: 10.1111/J.1432-1033.1984.TB08237.X  0.38
1984 Holland R, Witters LA, Hardie DG. Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase. European Journal of Biochemistry. 140: 325-33. PMID 6143665 DOI: 10.1111/J.1432-1033.1984.TB08105.X  0.413
1983 Ingebritsen TS, Blair J, Guy P, Witters L, Hardie DG. The protein phosphatases involved in cellular regulation. 3. Fatty acid synthesis, cholesterol synthesis and glycolysis/gluconeogenesis. European Journal of Biochemistry. 132: 275-81. PMID 6301826 DOI: 10.1111/J.1432-1033.1983.TB07359.X  0.328
1983 Holland R, Woodgett JR, Hardie DG. Evidence that amiloride antagonises insulin-stimulated protein phosphorylation by inhibiting protein kinase activity Febs Letters. 154: 269-273. PMID 6299802 DOI: 10.1016/0014-5793(83)80163-X  0.343
1983 Hardie DG, Guy PS. The regulation of enzyme activity by reversible phosphorylation. Progress in Brain Research. 56: 145-61. PMID 6298869 DOI: 10.1016/S0079-6123(08)63773-5  0.392
1981 Guy PS, Cohen P, Hardie DG. Purification and physicochemical properties of ATP citrate (pro-3S) lyase from lactating rat mammary gland and studies of its reversible phosphorylation. European Journal of Biochemistry. 114: 399-405. PMID 6260494 DOI: 10.1111/J.1432-1033.1981.Tb05160.X  0.398
1981 Brownsey RW, Hardie DG. Regulation of acetyl-CoA carboxylase: identity fo sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP-dependent protein kinase. Febs Letters. 120: 67-70. PMID 6108241 DOI: 10.1016/0014-5793(80)81048-9  0.35
1981 Hardie DG, Guy PS. Reversible phosphorylation and inactivation of acetyl-CoA carboxylase from lactating rat mammary gland by cyclic AMP-dependent protein kinase. European Journal of Biochemistry. 110: 167-77. PMID 6108209 DOI: 10.1111/J.1432-1033.1980.TB04852.X  0.432
1981 Guy PS, Aitken A, Hardie DG. STUDIES OF THE SITE ON ATP-CITRATE LYASE PHOSPHORYLATED BY CYCLIC AMP-DEPENDENT PROTEIN KINASE Biochemical Society Transactions. 9: 237P-237P. DOI: 10.1042/BST009237PC  0.338
1981 Hardie DG. ISOLATION OF TWO CYCLIC AMP-INDEPENDENT PROTEIN KINASES WHICH PHOSPHORYLATE ACETYL-COA CARBOXYLASE Biochemical Society Transactions. 9: 237P-237P. DOI: 10.1042/BST009237PB  0.341
1980 Guy PS, Cohen P, Hardie DG. Rat mammary gland ATP-citrate lyase is phosphorylated by cyclic amp-dependent protein kinase. Febs Letters. 109: 205-8. PMID 6243582 DOI: 10.1016/0014-5793(80)81087-8  0.412
1979 HARDIE DG. Regulation of Acetyl-Coenzyme A Carboxylase by Phosphorylation-Dephosphorylation Biochemical Society Transactions. 7: 228-228. DOI: 10.1042/BST0070228B  0.319
1977 Hardie DG, Stansfield DA. Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3':5'-cyclic monophosphate. The Biochemical Journal. 164: 213-21. PMID 195580 DOI: 10.1042/BJ1640213  0.335
1976 Hardie DG, Manners DJ, Yellowlees D. The limit dextrinase from malted sorghum (Sorghum vulgare). Carbohydrate Research. 50: 75-85. PMID 975121 DOI: 10.1016/S0008-6215(00)84084-7  0.493
1976 HARDIE DG, MATTHEWS HR, BRADBURY EM. Cell‐Cycle Dependence of Two Nuclear Histone Kinase Enzyme Activities European Journal of Biochemistry. 66: 37-42. PMID 182490 DOI: 10.1111/j.1432-1033.1976.tb10422.x  0.306
1974 Hardie DG, Manners DJ. A viscometric assay for pullulanase-type, debranching enzymes. Carbohydrate Research. 36: 207-10. PMID 4471984 DOI: 10.1016/S0008-6215(00)82010-8  0.497
1973 Dunn G, Hardie DG, Manners DJ. Observations of the action of limit dextrinases on amylopectin-like polysaccharides. The Biochemical Journal. 133: 413-6. PMID 4734116  0.501
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