David Grahame Hardie - Publications

Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom 
Biochemistry, Cell Biology

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, ... Hardie DG, et al. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research. PMID 30948787 DOI: 10.1038/s41422-019-0163-6  1
2018 Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM. Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical Journal. PMID 30135087 DOI: 10.1042/BCJ20180475  1
2018 Fyffe FA, Hawley SA, Gray A, Hardie DG. Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK. Methods in Molecular Biology (Clifton, N.J.). 1732: 69-86. PMID 29480469 DOI: 10.1007/978-1-4939-7598-3_5  1
2017 Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, ... ... Hardie DG, et al. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. PMID 28723898 DOI: 10.1038/nature23275  1
2017 Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG. Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chemical Biology. PMID 28625738 DOI: 10.1016/j.chembiol.2017.05.021  1
2016 Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG. The Na+/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes. PMID 27381369 DOI: 10.2337/db16-0058  1
2016 Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG. AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2. Molecular Cancer Research : McR. PMID 27141100 DOI: 10.1158/1541-7786.MCR-15-0479  1
2015 Hardie DG, Schaffer BE, Brunet A. AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends in Cell Biology. PMID 26616193 DOI: 10.1016/j.tcb.2015.10.013  1
2015 Schneider H, Schubert KM, Blodow S, Kreutz CP, Erdogmus S, Wiedenmann M, Qiu J, Fey T, Ruth P, Lubomirov LT, Pfitzer G, Mederos Y Schnitzler M, Hardie DG, Gudermann T, Pohl U. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle. Hypertension. 66: 108-16. PMID 26034200 DOI: 10.1161/HYPERTENSIONAHA.115.05514  1
2015 Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA. PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. The Biochemical Journal. 467: 461-72. PMID 25695398 DOI: 10.1042/BJ20141142  1
2015 Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 64: 360-9. PMID 25338814 DOI: 10.2337/db14-0508  1
2014 Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK. Chemistry & Biology. 21: 866-79. PMID 25036776 DOI: 10.1016/j.chembiol.2014.05.014  1
2014 Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. The Biochemical Journal. 459: 275-87. PMID 24467442 DOI: 10.1042/BJ20131344  1
2013 Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nature Medicine. 19: 1649-54. PMID 24185692 DOI: 10.1038/nm.3372  1
2013 Philp A, MacKenzie MG, Belew MY, Towler MC, Corstorphine A, Papalamprou A, Hardie DG, Baar K. Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle. Plos One. 8: e77200. PMID 24146969 DOI: 10.1371/journal.pone.0077200  1
2013 Gowans GJ, Hawley SA, Ross FA, Hardie DG. AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metabolism. 18: 556-66. PMID 24093679 DOI: 10.1016/j.cmet.2013.08.019  1
2013 Steinberg GR, Dandapani M, Hardie DG. AMPK: mediating the metabolic effects of salicylate-based drugs? Trends in Endocrinology and Metabolism: Tem. 24: 481-7. PMID 23871515 DOI: 10.1016/j.tem.2013.06.002  1
2013 Hardie DG, Alessi DR. LKB1 and AMPK and the cancer-metabolism link - ten years after. Bmc Biology. 11: 36. PMID 23587167 DOI: 10.1186/1741-7007-11-36  1
2012 Hardie DG, Ross FA, Hawley SA. AMP-activated protein kinase: a target for drugs both ancient and modern. Chemistry & Biology. 19: 1222-36. PMID 23102217 DOI: 10.1016/j.chembiol.2012.08.019  1
2012 Evans AM, Peers C, Wyatt CN, Kumar P, Hardie DG. Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level. Advances in Experimental Medicine and Biology. 758: 81-90. PMID 23080146 DOI: 10.1007/978-94-007-4584-1_11  1
2012 Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. The ancient drug salicylate directly activates AMP-activated protein kinase. Science (New York, N.Y.). 336: 918-22. PMID 22517326 DOI: 10.1126/science.1215327  1
2012 Turban S, Stretton C, Drouin O, Green CJ, Watson ML, Gray A, Ross F, Lantier L, Viollet B, Hardie DG, Marette A, Hundal HS. Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. The Journal of Biological Chemistry. 287: 20088-99. PMID 22511782 DOI: 10.1074/jbc.M111.330746  1
2012 Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature Reviews. Molecular Cell Biology. 13: 251-62. PMID 22436748 DOI: 10.1038/nrm3311  1
2011 Ikematsu N, Dallas ML, Ross FA, Lewis RW, Rafferty JN, David JA, Suman R, Peers C, Hardie DG, Evans AM. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability. Proceedings of the National Academy of Sciences of the United States of America. 108: 18132-7. PMID 22006306 DOI: 10.1073/pnas.1106201108  1
2011 Hardie DG, Carling D, Gamblin SJ. AMP-activated protein kinase: also regulated by ADP? Trends in Biochemical Sciences. 36: 470-7. PMID 21782450 DOI: 10.1016/j.tibs.2011.06.004  1
2011 Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L, Moulder-Thompson S, Dewar JA, Thompson AM. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Research and Treatment. 128: 783-94. PMID 21655990 DOI: 10.1007/s10549-011-1612-1  1
2011 zur Nedden S, Hawley S, Pentland N, Hardie DG, Doney AS, Frenguelli BG. Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6221-34. PMID 21508245 DOI: 10.1523/JNEUROSCI.4039-10.2011  1
2011 Green CJ, Macrae K, Fogarty S, Hardie DG, Sakamoto K, Hundal HS. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase. The Biochemical Journal. 435: 463-74. PMID 21323644 DOI: 10.1042/BJ20101517  1
2011 Ross FA, Rafferty JN, Dallas ML, Ogunbayo O, Ikematsu N, McClafferty H, Tian L, Widmer H, Rowe IC, Wyatt CN, Shipston MJ, Peers C, Hardie DG, Evans AM. Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase. The Journal of Biological Chemistry. 286: 11929-36. PMID 21209098 DOI: 10.1074/jbc.M110.189779  1
2011 Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, ... ... Hardie DG, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nature Genetics. 43: 117-20. PMID 21186350 DOI: 10.1038/ng.735  1
2011 Evans AM, Hardie DG, Peers C, Mahmoud A. Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing. Current Opinion in Anaesthesiology. 24: 13-20. PMID 21157304 DOI: 10.1097/ACO.0b013e3283421201  1
2010 Mankouri J, Tedbury PR, Gretton S, Hughes ME, Griffin SD, Dallas ML, Green KA, Hardie DG, Peers C, Harris M. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 107: 11549-54. PMID 20534540 DOI: 10.1073/pnas.0912426107  1
2010 Hawley SA, Ross FA, Chevtzoff C, Green KA, Evans A, Fogarty S, Towler MC, Brown LJ, Ogunbayo OA, Evans AM, Hardie DG. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metabolism. 11: 554-65. PMID 20519126 DOI: 10.1016/j.cmet.2010.04.001  1
2010 McDonald A, Fogarty S, Leclerc I, Hill EV, Hardie DG, Rutter GA. Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic β-cells: Evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement Biochemical Society Transactions. 38: 205-208. PMID 20074060 DOI: 10.1042/BST0380205  1
2010 Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: Synergistic effects of Ca2+ and AMP Biochemical Journal. 426: 109-118. PMID 19958286 DOI: 10.1042/BJ20091372  1
2009 McDonald A, Fogarty S, Leclerc I, Hill EV, Hardie DG, Rutter GA. Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation. Islets. 1: 198-209. PMID 21099273 DOI: 10.4161/isl.1.3.9608  1
2009 Evans AM, Hardie DG, Peers C, Wyatt CN, Viollet B, Kumar P, Dallas ML, Ross F, Ikematsu N, Jordan HL, Barr BL, Rafferty JN, Ogunbayo O. Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery. Annals of the New York Academy of Sciences. 1177: 89-100. PMID 19845611 DOI: 10.1111/j.1749-6632.2009.05041.x  1
2009 Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM. Histological evaluation of AMPK signalling in primary breast cancer. Bmc Cancer. 9: 307. PMID 19723334 DOI: 10.1186/1471-2407-9-307  1
2009 Fogarty S, Hardie DG. C-terminal phosphorylation of LKB1 Is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest Journal of Biological Chemistry. 284: 77-84. PMID 18854318 DOI: 10.1074/jbc.M806152200  1
2008 Towler MC, Fogarty S, Hawley SA, Pan DA, Martin DM, Morrice NA, McCarthy A, Galardo MN, Meroni SB, Cigorraga SB, Ashworth A, Sakamoto K, Hardie DG. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. The Biochemical Journal. 416: 1-14. PMID 18774945 DOI: 10.1042/BJ20081447  1
2008 Robertson TP, Mustard KJ, Lewis TH, Clark JH, Wyatt CN, Blanco EA, Peers C, Hardie DG, Evans AM. AMP-activated protein kinase and hypoxic pulmonary vasoconstriction. European Journal of Pharmacology. 595: 39-43. PMID 18703047 DOI: 10.1016/j.ejphar.2008.07.035  1
2008 McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. The Journal of Physiology. 586: 1731-41. PMID 18202101 DOI: 10.1113/jphysiol.2007.143685  1
2008 Wyatt CN, Pearson SA, Kumar P, Peers C, Hardie DG, Evans AM. Key roles for AMP-activated protein kinase in the function of the carotid body? Advances in Experimental Medicine and Biology. 605: 63-8. PMID 18085248 DOI: 10.1007/978-0-387-73693-8_11  1
2007 Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. The Journal of Biological Chemistry. 282: 32549-60. PMID 17855357 DOI: 10.1074/jbc.M706536200  1
1994 Davies SP, Hawley SA, Woods A, Carling D, Haystead TA, Hardie DG. Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. European Journal of Biochemistry / Febs. 223: 351-7. PMID 8055903 DOI: 10.1111/j.1432-1033.1994.tb19001.x  1
1991 Hardie DG, Haystead TAJ, Sim ATR. Use of okadaic acid to inhibit protein phosphatases in intact cells Methods in Enzymology. 201: 469-476. PMID 1658560  1
1990 Haystead TAJ, Moore F, Cohen P, Hardie DG. Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes European Journal of Biochemistry. 187: 199-205. PMID 1688796 DOI: 10.1111/j.1432-1033.1990.tb15295.x  1
1989 Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337: 78-81. PMID 2562908 DOI: 10.1038/337078a0  1
1988 Haystead TAJ, Campbell DG, Hardie DG. Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase European Journal of Biochemistry. 175: 347-354. PMID 2900140  1
1988 Haystead TAJ, Hardie DG. Insulin and phorbol ester stimulate phosphorylation of acety-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C European Journal of Biochemistry. 175: 339-345. PMID 2900139  1
1986 Haystead TAJ, Hardie DG. Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-M(r) effector and not by increased phosphorylation Biochemical Journal. 240: 99-106. PMID 2881538  1
1986 Munday MR, Haystead TA, Holland R, Carling DA, Hardie DG. The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. Biochemical Society Transactions. 14: 559-62. PMID 2874088  1
1986 Haystead TAJ, Hardie DG. Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay Biochemical Journal. 234: 279-284. PMID 2872882  1
1976 Hardie DG, Manners DJ, Yellowlees D. The limit dextrinase from malted sorghum (Sorghum vulgare). Carbohydrate Research. 50: 75-85. PMID 975121  1
1974 Hardie DG, Manners DJ. A viscometric assay for pullulanase-type, debranching enzymes. Carbohydrate Research. 36: 207-10. PMID 4471984  1
1973 Dunn G, Hardie DG, Manners DJ. Observations of the action of limit dextrinases on amylopectin-like polysaccharides. The Biochemical Journal. 133: 413-6. PMID 4734116  1
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