Kenji Watanabe - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
 Hokkaido University, Sapporo-shi, Hokkaidō, Japan 
 2010- University of Shizuoka, Shizuoka-shi, Shizuoka-ken, Japan 

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Year Citation  Score
2020 Tang Y, Gu J, Liu S, Watanabe K, Taniguchi T, Hone J, Mak KF, Shan J. Tuning layer-hybridized moiré excitons by the quantum-confined Stark effect. Nature Nanotechnology. PMID 33139934 DOI: 10.1038/s41565-020-00783-2  0.72
2020 Watanabe D, Murakami H, Ohno H, Tanisawa K, Konishi K, Tsunematsu Y, Sato M, Miyoshi N, Wakabayashi K, Watanabe K, Miyachi M. Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults. Scientific Reports. 10: 15221. PMID 32939005 DOI: 10.1038/s41598-020-72245-7  0.68
2020 Zhang Z, Qiao T, Watanabe K, Tang Y. Concise biosynthesis of phenylfuropyridones from fungi. Angewandte Chemie (International Ed. in English). PMID 32779306 DOI: 10.1002/anie.202008321  0.72
2020 Asai S, Tsunematsu Y, Masuya T, Otaka J, Osada H, Watanabe K. Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete. The Journal of Antibiotics. PMID 32759961 DOI: 10.1038/s41429-020-0355-9  0.68
2020 Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M. Artesunate Inhibits Intestinal Tumorigenesis through Inhibiting Wnt Signaling. Carcinogenesis. PMID 32710739 DOI: 10.1093/carcin/bgaa084  0.44
2020 Wang CY, Liang SJ, Wang S, Wang P, Li Z, Wang Z, Gao A, Pan C, Liu C, Liu J, Yang H, Liu X, Song W, Wang C, Cheng B, ... ... Watanabe K, et al. Gate-tunable van der Waals heterostructure for reconfigurable neural network vision sensor. Science Advances. 6: eaba6173. PMID 32637614 DOI: 10.1126/sciadv.aba6173  0.4
2020 Yoshikawa Y, Tsunematsu Y, Matsuzaki N, Hirayama Y, Higashiguchi F, Sato M, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Characterization of colibactin-producing Escherichia coli isolated from Japanese patients with colorectal cancer. Japanese Journal of Infectious Diseases. PMID 32475872 DOI: 10.7883/yoken.JJID.2020.066  0.68
2020 Lin D, Li S, Wen J, Berger H, Forró L, Zhou H, Jia S, Taniguchi T, Watanabe K, Xi X, Bahramy MS. Patterns and driving forces of dimensionality-dependent charge density waves in 2H-type transition metal dichalcogenides. Nature Communications. 11: 2406. PMID 32415071 DOI: 10.1038/s41467-020-15715-w  0.4
2020 Uchikawa M, Kato M, Nagata A, Sanada S, Yoshikawa Y, Tsunematsu Y, Sato M, Suzuki T, Hashidume T, Watanabe K, Yoshikawa Y, Miyoshi N. Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-A mice. Scientific Reports. 10: 5681. PMID 32231228 DOI: 10.1038/s41598-020-62541-7  0.68
2020 Tang Y, Li L, Li T, Xu Y, Liu S, Barmak K, Watanabe K, Taniguchi T, MacDonald AH, Shan J, Mak KF. Simulation of Hubbard model physics in WSe/WS moiré superlattices. Nature. 579: 353-358. PMID 32188950 DOI: 10.1038/s41586-020-2085-3  0.72
2020 Kawanishi M, Shimohara C, Oda Y, Hisatomi Y, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, ... Watanabe K, et al. Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of strains obtained from the Japan Collection of Microorganisms. Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society. 42: 12. PMID 32175032 DOI: 10.1186/s41021-020-00149-z  0.68
2020 Sarmales-Murga C, Akaoka F, Sato M, Takanishi J, Mino T, Miyoshi N, Watanabe K. A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity. The Journal of Antibiotics. PMID 32024969 DOI: 10.1038/s41429-020-0281-x  0.44
2019 Kawanishi M, Hisatomi Y, Oda Y, Shimohara C, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, ... Watanabe K, et al. In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient. The Journal of Toxicological Sciences. 44: 871-876. PMID 31813906 DOI: 10.2131/jts.44.871  0.68
2019 Takahashi K, Yoshino T, Maki Y, Ishiuchi K, Namiki T, Ogawa-Ochiai K, Minamizawa K, Makino T, Nakamura T, Mimura M, Watanabe K. Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study. Archives of Toxicology. PMID 31605160 DOI: 10.1007/s00204-019-02588-2  0.56
2019 Tsunematsu Y, Takanishi J, Asai S, Masuya T, Nakazawa T, Watanabe K. Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development. Organic Letters. PMID 31496254 DOI: 10.1021/acs.orglett.9b02861  0.68
2019 Kishimoto S, Tsunematsu Y, Matsushita T, Hara K, Hashimoto H, Tang Y, Watanabe K. Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis. Biochemistry. PMID 31486637 DOI: 10.1021/acs.biochem.9b00702  0.72
2019 Cheng B, Pan C, Che S, Wang P, Wu Y, Watanabe K, Taniguchi T, Ge S, Lake R, Smirnov D, Lau CN, Bockrath M. Fractional and Symmetry-Broken Chern Insulators in Tunable Moiré Superlattices. Nano Letters. PMID 31204812 DOI: 10.1021/acs.nanolett.9b00811  0.4
2019 Hirayama Y, Tsunematsu Y, Yoshikawa Y, Tamafune R, Matsuzaki N, Iwashita Y, Ohnishi I, Tanioka F, Sato M, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Wakabayashi K, Watanabe K. Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples. Organic Letters. PMID 31192617 DOI: 10.1021/acs.orglett.9b01345  0.68
2019 Wang Y, Wang L, Liu X, Wu H, Wang P, Yan D, Cheng B, Shi Y, Watanabe K, Taniguchi T, Liang SJ, Miao F. Direct evidence for charge compensation induced large magnetoresistance in thin WTe2. Nano Letters. PMID 31082263 DOI: 10.1021/acs.nanolett.9b01275  0.4
2019 Masuya T, Tsunematsu Y, Hirayama Y, Sato M, Noguchi H, Nakazawa T, Watanabe K. Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions. Organic & Biomolecular Chemistry. 17: 234-239. PMID 30556075 DOI: 10.1039/c8ob02814a  0.68
2018 Tsunematsu Y, Maeda N, Yokoyama M, Chankhamjon P, Watanabe K, Scherlach K, Hertweck C. Enzymatic Amide Tailoring Expedites Unusual Retro-Aldol-Type Amino Acid Conversion to Form Antifungal Cyclopeptide. Angewandte Chemie (International Ed. in English). PMID 30109903 DOI: 10.1002/anie.201806740  0.76
2018 Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K. Enzymatic one-step ring contraction for quinolone biosynthesis. Nature Communications. 9: 2826. PMID 30026518 DOI: 10.1038/s41467-018-05221-5  0.72
2018 Spanton EM, Zibrov AA, Zhou H, Taniguchi T, Watanabe K, Zaletel MP, Young AF. Observation of fractional Chern insulators in a van der Waals heterostructure. Science (New York, N.Y.). PMID 29496958 DOI: 10.1126/science.aan8458  0.4
2018 Li L, Tang MC, Tang S, Gao SS, Soliman SSM, Hang L, Xu W, Ye T, Watanabe K, Tang Y. Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. Journal of the American Chemical Society. PMID 29373009 DOI: 10.1021/jacs.8b00056  0.72
2017 Nakazawa T, Izuno A, Horii M, Kodera R, Nishimura H, Hirayama Y, Tsunematsu Y, Miyazaki Y, Awano T, Muraguchi H, Watanabe K, Sakamoto M, Takabe K, Watanabe T, Isagi Y, et al. Effects of pex1 disruption on wood lignin biodegradation, fruiting development and the utilization of carbon sources in the white-rot Agaricomycete Pleurotus ostreatus and non-wood decaying Coprinopsis cinerea. Fungal Genetics and Biology : Fg & B. PMID 29030267 DOI: 10.1016/j.fgb.2017.10.002  0.68
2017 Suwama T, Watanabe K, Monthakantirat O, Luecha P, Noguchi H, Watanabe K, Umehara K. Naphthalene glycosides in the Thai medicinal plant Diospyros mollis. Journal of Natural Medicines. PMID 29019024 DOI: 10.1007/s11418-017-1134-1  0.36
2017 Ohashi M, Liu F, Hai Y, Chen M, Tang MC, Yang Z, Sato M, Watanabe K, Houk KN, Tang Y. SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. Nature. PMID 28902839 DOI: 10.1038/nature23882  0.72
2017 Kishimoto S, Tsunematsu Y, Sato M, Watanabe K. Elucidation of biosynthetic pathways of natural products. Chemical Record (New York, N.Y.). PMID 28387469 DOI: 10.1002/tcr.201700015  0.68
2017 Yokoyama M, Hirayama Y, Yamamoto T, Kishimoto S, Tsunematsu Y, Watanabe K. Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide-Peptide Hybrid Biosynthesis. Organic Letters. PMID 28361537 DOI: 10.1021/acs.orglett.7b00559  0.68
2017 Zou Y, Garcia-Borràs M, Tang MC, Hirayama Y, Li DH, Li L, Watanabe K, Houk KN, Tang Y. Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. Nature Chemical Biology. PMID 28114276 DOI: 10.1038/nchembio.2283  0.72
2016 Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C. Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angewandte Chemie (International Ed. in English). PMID 27559694 DOI: 10.1002/anie.201604516  0.76
2016 Kishimoto S, Sato M, Tsunematsu Y, Watanabe K. Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids. Molecules (Basel, Switzerland). 21. PMID 27548127 DOI: 10.3390/molecules21081078  0.68
2016 Kato H, Tsunematsu Y, Yamamoto T, Namiki T, Kishimoto S, Noguchi H, Watanabe K. New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145. The Journal of Antibiotics. PMID 27189118 DOI: 10.1038/ja.2016.54  0.68
2016 Yamamoto T, Tsunematsu Y, Hara K, Suzuki T, Kishimoto S, Kawagishi H, Noguchi H, Hashimoto H, Tang Y, Hotta K, Watanabe K. Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 27072782 DOI: 10.1002/anie.201600940  0.64
2016 Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Y, Watanabe K. Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis. Organic Letters. PMID 26959241 DOI: 10.1021/acs.orglett.6b00380  0.64
2015 Yamamoto T, Tsunematsu Y, Noguchi H, Hotta K, Watanabe K. Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation. Organic Letters. PMID 26414728 DOI: 10.1021/acs.orglett.5b02435  0.64
2015 Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem : a European Journal of Chemical Biology. PMID 26360642 DOI: 10.1002/cbic.201500386  0.64
2015 Zou Y, Zhan Z, Li D, Tang M, Cacho RA, Watanabe K, Tang Y. Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids. Journal of the American Chemical Society. 137: 4980-3. PMID 25859931 DOI: 10.1021/jacs.5b03022  0.72
2015 Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, et al. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 521: 541-4. PMID 25799992 DOI: 10.1038/nature14328  0.64
2015 Wong FT, Hotta K, Chen X, Fang M, Watanabe K, Kim CY. Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis. Journal of the American Chemical Society. 137: 86-9. PMID 25535803 DOI: 10.1021/ja511374k  0.56
2014 Zou Y, Xu W, Tsunematsu Y, Tang M, Watanabe K, Tang Y. Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis. Organic Letters. 16: 6390-3. PMID 25494235 DOI: 10.1021/ol503179v  0.72
2014 Ishikawa N, Tanaka H, Koyama F, Noguchi H, Wang CC, Hotta K, Watanabe K. Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. Angewandte Chemie (International Ed. in English). 53: 12880-4. PMID 25251934 DOI: 10.1002/anie.201407920  0.64
2014 Tsunematsu Y, Fukutomi M, Saruwatari T, Noguchi H, Hotta K, Tang Y, Watanabe K. Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity. Angewandte Chemie (International Ed. in English). 53: 8475-9. PMID 24939566 DOI: 10.1002/anie.201404804  0.64
2014 Saruwatari T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K. Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis. Chembiochem : a European Journal of Chemical Biology. 15: 656-9. PMID 24677498 DOI: 10.1002/cbic.201300751  0.64
2014 Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. Journal of the American Chemical Society. 136: 4426-36. PMID 24568283 DOI: 10.1021/ja500881e  0.64
2014 Hotta K, Keegan RM, Ranganathan S, Fang M, Bibby J, Winn MD, Sato M, Lian M, Watanabe K, Rigden DJ, Kim CY. Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis. Angewandte Chemie (International Ed. in English). 53: 824-8. PMID 24302672 DOI: 10.1002/anie.201307404  0.64
2013 Tsunematsu Y, Ishikawa N, Wakana D, Goda Y, Noguchi H, Moriya H, Hotta K, Watanabe K. Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk. Nature Chemical Biology. 9: 818-25. PMID 24121553 DOI: 10.1038/nchembio.1366  0.64
2013 Nakazawa T, Ishiuchi K, Sato M, Tsunematsu Y, Sugimoto S, Gotanda Y, Noguchi H, Hotta K, Watanabe K. Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol. Journal of the American Chemical Society. 135: 13446-55. PMID 23941144 DOI: 10.1021/ja405128k  0.68
2013 Sato M, Nakazawa T, Tsunematsu Y, Hotta K, Watanabe K. Echinomycin biosynthesis. Current Opinion in Chemical Biology. 17: 537-45. PMID 23856054 DOI: 10.1016/j.cbpa.2013.06.022  0.68
2013 Tsunematsu Y, Ishiuchi K, Hotta K, Watanabe K. Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products. Natural Product Reports. 30: 1139-49. PMID 23824111 DOI: 10.1039/c3np70037b  0.68
2012 Winter JM, Sato M, Sugimoto S, Chiou G, Garg NK, Tang Y, Watanabe K. Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. Journal of the American Chemical Society. 134: 17900-3. PMID 23072467 DOI: 10.1021/ja3090498  0.64
2012 Tsunematsu Y, Ichinoseki S, Nakazawa T, Ishikawa N, Noguchi H, Hotta K, Watanabe K. Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis. The Journal of Antibiotics. 65: 377-80. PMID 22569160 DOI: 10.1038/ja.2012.34  0.68
2012 Minami A, Shimaya M, Suzuki G, Migita A, Shinde SS, Sato K, Watanabe K, Tamura T, Oguri H, Oikawa H. Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis. Journal of the American Chemical Society. 134: 7246-9. PMID 22506807 DOI: 10.1021/ja301386g  0.64
2012 Nakazawa T, Ishiuchi K, Praseuth A, Noguchi H, Hotta K, Watanabe K. Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce a novel polyketide. Chembiochem : a European Journal of Chemical Biology. 13: 855-61. PMID 22447538 DOI: 10.1002/cbic.201200107  0.64
2012 Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H, Hotta K, Moriya H, Watanabe K. Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics. Chembiochem : a European Journal of Chemical Biology. 13: 846-54. PMID 22447505 DOI: 10.1002/cbic.201100798  0.68
2012 Hotta K, Chen X, Paton RS, Minami A, Li H, Swaminathan K, Mathews II, Watanabe K, Oikawa H, Houk KN, Kim CY. Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature. 483: 355-8. PMID 22388816 DOI: 10.1038/nature10865  0.64
2011 Saruwatari T, Praseuth AP, Sato M, Torikai K, Noguchi H, Watanabe K. A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases. The Journal of Antibiotics. 64: 9-17. PMID 21102597 DOI: 10.1038/ja.2010.130  0.64
2009 Pickens LB, Kim W, Wang P, Zhou H, Watanabe K, Gomi S, Tang Y. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. Journal of the American Chemical Society. 131: 17677-89. PMID 19908837 DOI: 10.1021/ja907852c  0.64
2009 Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. Journal of the American Chemical Society. 131: 9347-53. PMID 19514719 DOI: 10.1021/ja902261a  0.64
2009 Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP. Chromatin-level regulation of biosynthetic gene clusters. Nature Chemical Biology. 5: 462-4. PMID 19448638 DOI: 10.1038/nchembio.177  0.64
2008 Zhan J, Watanabe K, Tang Y. Synergistic actions of a monooxygenase and cyclases in aromatic polyketide biosynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1710-5. PMID 18604835 DOI: 10.1002/cbic.200800178  0.72
2008 Chiang YM, Szewczyk E, Nayak T, Davidson AD, Sanchez JF, Lo HC, Ho WY, Simityan H, Kuo E, Praseuth A, Watanabe K, Oakley BR, Wang CC. Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chemistry & Biology. 15: 527-32. PMID 18559263 DOI: 10.1016/j.chembiol.2008.05.010  0.64
2008 Zhou H, Zhan J, Watanabe K, Xie X, Tang Y. A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences of the United States of America. 105: 6249-54. PMID 18427109 DOI: 10.1073/pnas.0800657105  0.64
2008 Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J. Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. Journal of the American Chemical Society. 130: 6068-9. PMID 18422316 DOI: 10.1021/ja800951e  0.64
2008 Praseuth AP, Praseuth MB, Oguri H, Oikawa H, Watanabe K, Wang CC. Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture. Biotechnology Progress. 24: 134-9. PMID 18173279 DOI: 10.1021/bp070298y  0.64
2007 Zhang W, Watanabe K, Wang CC, Tang Y. Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. The Journal of Biological Chemistry. 282: 25717-25. PMID 17631493 DOI: 10.1074/jbc.M703437200  0.72
2007 Zhang W, Wilke BI, Zhan J, Watanabe K, Boddy CN, Tang Y. A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society. 129: 9304-5. PMID 17625867 DOI: 10.1021/ja0736919  0.64
2007 Watanabe K, Praseuth AP, Wang CC. A comprehensive and engaging overview of the type III family of polyketide synthases. Current Opinion in Chemical Biology. 11: 279-86. PMID 17482864 DOI: 10.1016/j.cbpa.2006.11.041  0.64
2006 Zhang W, Watanabe K, Wang CC, Tang Y. Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase. Journal of Natural Products. 69: 1633-6. PMID 17125237 DOI: 10.1021/np060290i  0.72
2006 Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chemistry & Biology. 13: 1161-9. PMID 17113998 DOI: 10.1016/j.chembiol.2006.09.008  0.64
2006 Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CC, Oguri H, Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nature Chemical Biology. 2: 423-8. PMID 16799553 DOI: 10.1038/nchembio803  0.64
2004 Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I. Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase. The Journal of Biological Chemistry. 279: 37956-63. PMID 15231835 DOI: 10.1074/jbc.M406144200  0.64
2004 Toyomasu T, Nakaminami K, Toshima H, Mie T, Watanabe K, Ito H, Matsui H, Mitsuhashi W, Sassa T, Oikawa H. Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha. Bioscience, Biotechnology, and Biochemistry. 68: 146-52. PMID 14745177 DOI: 10.1271/bbb.68.146  0.64
2003 Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/j.jmb.2003.10.021  0.64
2003 Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of Biological Chemistry. 278: 42020-6. PMID 12923197 DOI: 10.1074/jbc.M305339200  0.64
2003 Watanabe K, Rude MA, Walsh CT, Khosla C. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 9774-8. PMID 12888623 DOI: 10.1073/pnas.1632167100  0.72
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