Year |
Citation |
Score |
2022 |
Xu G, Liu Z, Wang X, Lu T, DesJarlais RL, Thieu T, Zhang J, Devine ZH, Du F, Li Q, Milligan CM, Shaffer P, Cedervall PE, Spurlino JC, Stratton CF, et al. Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. Journal of Medicinal Chemistry. PMID 35862732 DOI: 10.1021/acs.jmedchem.2c00442 |
0.323 |
|
2017 |
Barbay JK, Cummings MD, Abad M, Castro G, Kreutter KD, Kummer DA, Maharoof U, Milligan C, Nishimura R, Pierce J, Schalk-Hihi C, Spurlino J, Tanis VM, Urbanski M, Venkatesan H, et al. 6-Substituted quinolines as RORγt inverse agonists. Bioorganic & Medicinal Chemistry Letters. PMID 29079472 DOI: 10.1016/J.Bmcl.2017.10.027 |
0.332 |
|
2008 |
Kervinen J, Abad M, Crysler C, Kolpak M, Mahan AD, Masucci JA, Bayoumy S, Cummings MD, Yao X, Olson M, De Garavilla L, Kuo L, Deckman I, Spurlino J. Structural basis for elastolytic substrate specificity in rodent α-chymases Journal of Biological Chemistry. 283: 427-436. PMID 17981788 DOI: 10.1074/jbc.M707157200 |
0.3 |
|
2008 |
Abad MC, Askari H, O'Neill J, Klinger AL, Milligan C, Lewandowski F, Springer B, Spurlino J, Rentzeperis D. Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. The Journal of Steroid Biochemistry and Molecular Biology. 108: 44-54. PMID 17964775 DOI: 10.1016/j.jsbmb.2007.06.006 |
0.305 |
|
2007 |
Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA. Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors Journal of Biological Chemistry. 282: 4094-4101. PMID 17132624 DOI: 10.1074/Jbc.M608183200 |
0.426 |
|
2004 |
Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis Bioorganic and Medicinal Chemistry Letters. 14: 3727-3731. PMID 15203151 DOI: 10.1016/J.Bmcl.2004.05.002 |
0.353 |
|
2004 |
Subasinghe NL, Ali F, Illig CR, Rudolph MJ, Klein S, Khalil E, Soll RM, Bone RF, Spurlino JC, DesJarlais RL, Crysler CS, Cummings MD, Morris PE, Kilpatrick JM, Babu YS. A novel series of potent and selective small molecule inhibitors of the complement component C1s Bioorganic and Medicinal Chemistry Letters. 14: 3043-3047. PMID 15149641 DOI: 10.1016/J.Bmcl.2004.04.034 |
0.302 |
|
2003 |
Tomczuk B, Lu T, Soll RM, Fedde C, Wang A, Murphy L, Crysler C, Dasgupta M, Eisennagel S, Spurlino J, Bone R. Oxyguanidines: Application to non-peptidic phenyl-based thrombin inhibitors Bioorganic and Medicinal Chemistry Letters. 13: 1495-1498. PMID 12668020 DOI: 10.1016/S0960-894X(03)00125-2 |
0.332 |
|
2002 |
Rudolph MJ, Illig CR, Subasinghe NL, Wilson KJ, Hoffman JB, Randle T, Green D, Molloy CJ, Soll RM, Lewandowski F, Zhang M, Bone R, Spurlino JC, Deckman IC, Manthey C, et al. Design and Synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors Bioorganic and Medicinal Chemistry Letters. 12: 491-495. PMID 11814826 DOI: 10.1016/S0960-894X(01)00787-9 |
0.373 |
|
2001 |
Subasinghe NL, Illig C, Hoffman J, Rudolph MJ, Wilson KJ, Soll R, Randle T, Green D, Lewandowski F, Zhang M, Bone R, Spurlino J, DesJarlais R, Deckman I, Molloy CJ, et al. Structure-Based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors Bioorganic and Medicinal Chemistry Letters. 11: 1379-1382. PMID 11378359 DOI: 10.1016/S0960-894X(01)00247-5 |
0.454 |
|
2001 |
Wilson KJ, Illig CR, Subasinghe N, Hoffman JB, Jonathan Rudolph M, Soll R, Molloy CJ, Bone R, Green D, Randall T, Zhang M, Lewandowski FA, Zhou Z, Sharp C, Maguire D, ... ... Spurlino J, et al. Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors Bioorganic and Medicinal Chemistry Letters. 11: 915-918. PMID 11294390 DOI: 10.1016/S0960-894X(01)00102-0 |
0.33 |
|
2000 |
Lu T, Soll RM, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Tomczuk BE. Structure-activity and crystallographic analysis of a new class of non- amide-based thrombin inhibitor Bioorganic and Medicinal Chemistry Letters. 10: 79-82. PMID 10636249 DOI: 10.1016/S0960-894X(99)00617-4 |
0.448 |
|
2000 |
Soll RM, Lu T, Tomczuk B, Illig CR, Fedde C, Eisennagel S, Bone R, Murphy L, Spurlino J, Salemme FR. Amidinohydrazones as guanidine bioisosteres: Application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors Bioorganic and Medicinal Chemistry Letters. 10: 1-4. PMID 10636229 DOI: 10.1016/S0960-894X(99)00632-0 |
0.398 |
|
1998 |
Lu T, Tomczuk B, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Soll RM. In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors Bioorganic and Medicinal Chemistry Letters. 8: 1595-1600. PMID 9873397 DOI: 10.1016/S0960-894X(98)00290-X |
0.393 |
|
1998 |
Bone R, Lu T, Illig CR, Soll RM, Spurlino JC. Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes Journal of Medicinal Chemistry. 41: 2068-2075. PMID 9622548 DOI: 10.1021/Jm970796L |
0.414 |
|
1997 |
Quiocho FA, Spurlino JC, Rodseth LE. Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor. Structure (London, England : 1993). 5: 997-1015. PMID 9309217 DOI: 10.1016/S0969-2126(97)00253-0 |
0.59 |
|
1997 |
Salemme FR, Spurlino J, Bone R. Serendipity meets precision: The integration of structure-based drug design and combinatorial chemistry for efficient drug discovery Structure. 5: 319-324. PMID 9083110 DOI: 10.1016/S0969-2126(97)00189-5 |
0.332 |
|
1996 |
Quiocho FA, Vyas NK, Vyas MN, Spurlino JC, Rodseth LE, Bundle DR. Atomic interactions between proteins and carbohydrates Acta Crystallographica Section a Foundations of Crystallography. 52: C191-C191. DOI: 10.1107/S0108767396091660 |
0.354 |
|
1994 |
Spurlino JC, Smallwood AM, Carlton DD, Banks TM, Vavra KJ, Johnson JS, Cook ER, Falvo J, Wahl RC, Pulvino TA. 1.56 A structure of mature truncated human fibroblast collagenase. Proteins. 19: 98-109. PMID 8090713 DOI: 10.1002/prot.340190203 |
0.302 |
|
1993 |
Guevara J, Spurlino J, Jan AY, Yang CY, Tulinsky A, Prasad BV, Gaubatz JW, Morrisett JD. Proposed mechanisms for binding of apo[a] kringle type 9 to apo B-100 in human lipoprotein[a]. Biophysical Journal. 64: 686-700. PMID 8386013 DOI: 10.1016/S0006-3495(93)81428-0 |
0.353 |
|
1992 |
Spurlino JC, Rodseth LE, Quiocho FA. Atomic interactions in protein-carbohydrate complexes. Tryptophan residues in the periplasmic maltodextrin receptor for active transport and chemotaxis. Journal of Molecular Biology. 226: 15-22. PMID 1619648 DOI: 10.1016/0022-2836(92)90119-5 |
0.569 |
|
1992 |
Sharff AJ, Rodseth LE, Spurlino JC, Quiocho FA. Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis. Biochemistry. 31: 10657-63. PMID 1420181 DOI: 10.1021/Bi00159A003 |
0.551 |
|
1991 |
Spurlino JC, Lu GY, Quiocho FA. The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. The Journal of Biological Chemistry. 266: 5202-19. PMID 2002054 DOI: 10.2210/Pdb1Mbp/Pdb |
0.581 |
|
1990 |
Ruan KH, Spurlino J, Quiocho FA, Atassi MZ. Acetylcholine receptor-α-bungarotoxin interactions: Determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity Proceedings of the National Academy of Sciences of the United States of America. 87: 6156-6160. PMID 2385590 DOI: 10.1073/Pnas.87.16.6156 |
0.457 |
|
1990 |
Martineau P, Szmelcman S, Spurlino JC, Quiocho FA, Hofnung M. Genetic approach to the role of tryptophan residues in the activities and fluorescence of a bacterial periplasmic maltose-binding protein. Journal of Molecular Biology. 214: 337-52. PMID 2196376 DOI: 10.1016/0022-2836(90)90165-I |
0.566 |
|
1990 |
Martineau P, Saurin W, Hofnung M, Spurlino JC, Quiocho FA. Progress in the identification of interaction sites on the periplasmic maltose binding protein from E coli. Biochimie. 72: 397-402. PMID 2124143 DOI: 10.1016/0300-9084(90)90063-M |
0.5 |
|
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