| Year |
Citation |
Score |
| 2022 |
Mathes F, Gilbert N, Newcomer M. Non-Competitive Inhibition by a Substrate Mimetic of Human 5-Lipoxygenase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35560542 DOI: 10.1096/fasebj.2022.36.S1.R5916 |
0.347 |
|
| 2020 |
Gilbert NC, Gerstmeier J, Schexnaydre EE, Börner F, Garscha U, Neau DB, Werz O, Newcomer ME. Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nature Chemical Biology. PMID 32393899 DOI: 10.1038/S41589-020-0544-7 |
0.437 |
|
| 2019 |
Newcomer ME. Chloride to the rescue. The Journal of Biological Chemistry. 294: 11402-11403. PMID 31350284 DOI: 10.1074/Jbc.H119.009687 |
0.326 |
|
| 2019 |
Pakhomova S, Boeglin WE, Neau DB, Bartlett SG, Brash AR, Newcomer ME. An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Science : a Publication of the Protein Society. PMID 30861228 DOI: 10.2210/Pdb6Ns2/Pdb |
0.37 |
|
| 2018 |
Schexnaydre EE, Gerstmeier J, Garscha U, Jordan PM, Werz O, Newcomer ME. A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30291962 DOI: 10.1016/J.Bbalip.2018.09.011 |
0.397 |
|
| 2018 |
Gilbert NC, Neau DB, Newcomer ME. Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla. Methods in Enzymology. 605: 33-49. PMID 29909831 DOI: 10.1016/Bs.Mie.2018.02.010 |
0.345 |
|
| 2018 |
Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. PMID 29366648 DOI: 10.1016/J.Bmcl.2018.01.003 |
0.3 |
|
| 2017 |
Wang C, Pakhomova S, Newcomer ME, Christner BC, Luo BH. Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein. Plos One. 12: e0187169. PMID 29108002 DOI: 10.1371/Journal.Pone.0187169 |
0.375 |
|
| 2016 |
Mashhadi Z, Newcomer ME, Brash AR. The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides. Chembiochem : a European Journal of Chemical Biology. PMID 27653176 DOI: 10.1002/Cbic.201600345 |
0.398 |
|
| 2016 |
Bender G, Schexnaydre EE, Murphy RC, Uhlson C, Newcomer ME. Membrane-dependent Activities of Human 15-LOX-2 and its Murine Counterpart: Implications for Murine Models of Atherosclerosis. The Journal of Biological Chemistry. PMID 27435673 DOI: 10.1074/Jbc.M116.741454 |
0.352 |
|
| 2016 |
Gerstmeier J, Newcomer ME, Dennhardt S, Romp E, Fischer J, Werz O, Garscha U. 5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26842853 DOI: 10.1096/Fj.201500210R |
0.316 |
|
| 2015 |
Mitra S, Bartlett SG, Newcomer ME. Identification of the Substrate Access Portal of 5-Lipoxygenase. Biochemistry. PMID 26427761 DOI: 10.1021/Acs.Biochem.5B00930 |
0.411 |
|
| 2015 |
Newcomer ME, Brash AR. The structural basis for specificity in lipoxygenase catalysis. Protein Science : a Publication of the Protein Society. 24: 298-309. PMID 25524168 DOI: 10.1002/Pro.2626 |
0.451 |
|
| 2014 |
Neau DB, Bender G, Boeglin WE, Bartlett SG, Brash AR, Newcomer ME. Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. The Journal of Biological Chemistry. 289: 31905-13. PMID 25231982 DOI: 10.1074/Jbc.M114.599662 |
0.469 |
|
| 2014 |
Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C. Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate Biochemical and Biophysical Research Communications. 449: 392-398. PMID 24858690 DOI: 10.1016/J.Bbrc.2014.05.064 |
0.452 |
|
| 2014 |
Luka Z, Pakhomova S, Loukachevitch LV, Calcutt MW, Newcomer ME, Wagner C. Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate Protein Science. 23: 993-998. PMID 24715612 DOI: 10.1002/Pro.2469 |
0.346 |
|
| 2014 |
Kobe MJ, Neau DB, Mitchell CE, Bartlett SG, Newcomer ME. The structure of human 15-lipoxygenase-2 with a substrate mimic. The Journal of Biological Chemistry. 289: 8562-9. PMID 24497644 DOI: 10.1074/Jbc.M113.543777 |
0.428 |
|
| 2013 |
Pecic S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD, Zhu Z, Rinderspacher A, Deng SX. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors Bioorganic and Medicinal Chemistry Letters. 23: 417-421. PMID 23237835 DOI: 10.1016/J.Bmcl.2012.11.084 |
0.308 |
|
| 2012 |
Eek P, Järving R, Järving I, Gilbert NC, Newcomer ME, Samel N. Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation Journal of Biological Chemistry. 287: 22377-22386. PMID 22573333 DOI: 10.1074/Jbc.M112.343285 |
0.412 |
|
| 2012 |
Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C. Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate Biochimica Et Biophysica Acta - Proteins and Proteomics. 1824: 286-291. PMID 22037183 DOI: 10.1016/J.Bbapap.2011.10.008 |
0.364 |
|
| 2011 |
Pakhomova S, Bartlett SG, Doerner PA, Newcomer ME. Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry. 50: 6909-19. PMID 21728358 DOI: 10.1021/Bi2004334 |
0.332 |
|
| 2010 |
Newcomer ME, Gilbert NC. Location, location, location: compartmentalization of early events in leukotriene biosynthesis. The Journal of Biological Chemistry. 285: 25109-14. PMID 20507998 DOI: 10.1074/Jbc.R110.125880 |
0.377 |
|
| 2009 |
Pakhomova S, Gao B, Boeglin WE, Brash AR, Newcomer ME. The structure and peroxidase activity of a 33-kDa catalase-related protein from Mycobacterium avium ssp. paratuberculosis Protein Science. 18: 2559-2568. PMID 19827095 DOI: 10.1002/Pro.265 |
0.417 |
|
| 2009 |
Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, Newcomer ME. The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry. 48: 7906-15. PMID 19594169 DOI: 10.1021/Bi900084M |
0.325 |
|
| 2009 |
Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, Newcomer ME. The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry. 48: 7906-15. PMID 19594169 DOI: 10.1021/Bi900084M |
0.325 |
|
| 2008 |
Pakhomova S, Bartlett SG, Augustus A, Kuzuyama T, Newcomer ME. Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis. The Journal of Biological Chemistry. 283: 28518-26. PMID 18701452 DOI: 10.1074/Jbc.M803709200 |
0.336 |
|
| 2008 |
Pakhomova S, Bartlett SG, Augustus A, Kuzuyama T, Newcomer ME. Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis. The Journal of Biological Chemistry. 283: 28518-26. PMID 18701452 DOI: 10.1074/Jbc.M803709200 |
0.336 |
|
| 2007 |
Neau DB, Gilbert NC, Bartlett SG, Dassey A, Newcomer ME. Improving protein crystal quality by selective removal of a Ca 2+-dependent membrane-insertion loop Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63: 972-975. PMID 18007054 DOI: 10.1107/S1744309107050993 |
0.36 |
|
| 2007 |
Luka Z, Pakhomova S, Luka Y, Newcomer ME, Wagner C. Destabilization of human glycine N-methyltransferase by H176N mutation Protein Science. 16: 1957-1964. PMID 17660255 DOI: 10.1110/Ps.072921507 |
0.358 |
|
| 2007 |
Fillgrove KL, Pakhomova S, Schaab MR, Newcomer ME, Armstrong RN. Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. Biochemistry. 46: 8110-20. PMID 17567049 DOI: 10.1021/Bi700625P |
0.386 |
|
| 2007 |
Fillgrove KL, Pakhomova S, Schaab MR, Newcomer ME, Armstrong RN. Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes. Biochemistry. 46: 8110-20. PMID 17567049 DOI: 10.1021/Bi700625P |
0.386 |
|
| 2007 |
Luka Z, Pakhomova S, Loukachevitch LV, Egli M, Newcomer ME, Wagner C. 5-Methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase Journal of Biological Chemistry. 282: 4069-4075. PMID 17158459 DOI: 10.1074/Jbc.M610384200 |
0.414 |
|
| 2006 |
Bordelon T, Wilkinson SP, Grove A, Newcomer ME. The Crystal Structure of the Transcriptional Regulator HucR from Deinococcus radiodurans Reveals a Repressor Preconfigured for DNA Binding Journal of Molecular Biology. 360: 168-177. PMID 16750221 DOI: 10.1016/J.Jmb.2006.05.005 |
0.364 |
|
| 2006 |
Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, Holley S, Al-Kassim L, Spessard C, Melnick M, Newcomer M, Waldrop GL. The structure of the carboxyltransferase component of acetyl-CoA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme Biochemistry. 45: 1712-1722. PMID 16460018 DOI: 10.1021/Bi0520479 |
0.416 |
|
| 2006 |
Vander Kooi CW, Ohi MD, Rosenberg JA, Oldham ML, Newcomer ME, Gould KL, Chazin WJ. The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases Biochemistry. 45: 121-130. PMID 16388587 DOI: 10.1021/Bi051787E |
0.668 |
|
| 2005 |
Oldham ML, Brash AR, Newcomer ME. Insights from the x-ray crystal structure of coral 8R-lipoxygenase: Calcium activation via a C2-like domain and a structural basis of product chirality Journal of Biological Chemistry. 280: 39545-39552. PMID 16162493 DOI: 10.1074/Jbc.M506675200 |
0.68 |
|
| 2005 |
Oldham ML, Brash AR, Newcomer ME. The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide Proceedings of the National Academy of Sciences of the United States of America. 102: 297-302. PMID 15625113 DOI: 10.1073/Pnas.0406352102 |
0.702 |
|
| 2005 |
Pakhomova S, Buck J, Newcomer ME. The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition Protein Science. 14: 176-182. PMID 15608121 DOI: 10.1110/Ps.041061105 |
0.445 |
|
| 2004 |
Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME. Glycine N-methyltransferases: A comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes Proteins: Structure, Function and Genetics. 57: 331-337. PMID 15340920 DOI: 10.1002/Prot.20209 |
0.414 |
|
| 2004 |
Bordelon T, Montegudo SK, Pakhomova S, Oldham ML, Newcomer ME. A disorder to order transition accompanies catalysis in retinaldehyde dehydrogenase type II Journal of Biological Chemistry. 279: 43085-43091. PMID 15299009 DOI: 10.1074/Jbc.M406139200 |
0.695 |
|
| 2004 |
Pakhomova S, Rife CL, Armstrong RN, Newcomer ME. Structure of fosfomycin resistance protein FosA from transposon Tn2921. Protein Science : a Publication of the Protein Society. 13: 1260-5. PMID 15075406 DOI: 10.1110/Ps.03585004 |
0.324 |
|
| 2004 |
Pakhomova S, Rife CL, Armstrong RN, Newcomer ME. Structure of fosfomycin resistance protein FosA from transposon Tn2921. Protein Science : a Publication of the Protein Society. 13: 1260-5. PMID 15075406 DOI: 10.1110/Ps.03585004 |
0.324 |
|
| 2004 |
Bilder PW, Ding H, Newcomer ME. Crystal Structure of the Ancient, Fe-S Scaffold IscA Reveals a Novel Protein Fold Biochemistry. 43: 133-139. PMID 14705938 DOI: 10.1021/Bi035440S |
0.405 |
|
| 2003 |
Fillgrove KL, Pakhomova S, Newcomer ME, Armstrong RN. Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. Journal of the American Chemical Society. 125: 15730-1. PMID 14677948 DOI: 10.1021/Ja039307Z |
0.3 |
|
| 2003 |
Fillgrove KL, Pakhomova S, Newcomer ME, Armstrong RN. Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. Journal of the American Chemical Society. 125: 15730-1. PMID 14677948 DOI: 10.1021/Ja039307Z |
0.3 |
|
| 2002 |
Newcomer ME. Protein folding and three-dimensional domain swapping: A strained relationship? Current Opinion in Structural Biology. 12: 48-53. PMID 11839489 DOI: 10.1016/S0959-440X(02)00288-9 |
0.334 |
|
| 2001 |
Pakhomova S, Kobayashi M, Buck J, Newcomer ME. A helical lid converts a sulfotransferase to a dehydratase Nature Structural Biology. 8: 447-451. PMID 11323722 DOI: 10.1038/87617 |
0.324 |
|
| 1999 |
Lamb AL, Newcomer ME. The structure of retinal dehydrogenase type II at 2.7 Å resolution: Implications for retinal specificity Biochemistry. 38: 6003-6011. PMID 10320326 DOI: 10.1021/Bi9900471 |
0.615 |
|
| 1999 |
Lamb AL, Newcomer ME. The structure of retinal dehydrogenase type II at 2.7 Å resolution: Implications for retinal specificity Biochemistry. 38: 6003-6011. PMID 10320326 DOI: 10.1021/Bi9900471 |
0.615 |
|
| 1999 |
Naylor HM, Newcomer ME. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP Biochemistry. 38: 2647-2653. PMID 10052934 DOI: 10.1021/Bi982291I |
0.401 |
|
| 1998 |
Lamb AL, Wang X, Napoli JL, Newcomer ME. Purification, crystallization and preliminary X-ray diffraction studies of retinal dehydrogenase type II. Acta Crystallographica. Section D, Biological Crystallography. 54: 639-42. PMID 9761861 DOI: 10.1107/S0907444997014121 |
0.693 |
|
| 1998 |
Lamb AL, Wang X, Napoli JL, Newcomer ME. Purification, crystallization and preliminary X-ray diffraction studies of retinal dehydrogenase type II. Acta Crystallographica. Section D, Biological Crystallography. 54: 639-42. PMID 9761861 DOI: 10.1107/S0907444997014121 |
0.693 |
|
| 1998 |
Pattanayek R, Newcomer ME, Wagner C. Crystal structure of apo-glycine N-methyltransferase (GNMT) Protein Science. 7: 1326-1331. PMID 9655336 |
0.346 |
|
| 1994 |
Jamison RS, Newcomer ME, Ong DE. Cellular retinoid-binding proteins: limited proteolysis reveals a conformational change upon ligand binding. Biochemistry. 33: 2873-9. PMID 8130200 DOI: 10.1021/Bi00176A017 |
0.407 |
|
| 1993 |
Newcomer ME. Structure of the epididymal retinoic acid binding protein at 2.1 Å resolution Structure. 1: 7-18. PMID 8069623 DOI: 10.1016/0969-2126(93)90004-Z |
0.306 |
|
| 1989 |
Burrows GG, Newcomer ME, Hazelbauer GL. Purification of receptor protein Trg by exploiting a property common to chemotactic transducers of Escherichia coli Journal of Biological Chemistry. 264: 17309-17315. PMID 2677004 |
0.61 |
|
| 1981 |
Newcomer ME, Lewis BA, Quiocho FA. The radius of gyration of L-arabinose-binding protein decreases upon binding of ligand. The Journal of Biological Chemistry. 256: 13218-22. PMID 7031058 |
0.413 |
|
| 1981 |
Newcomer ME, Lewis BA, Quiocho FA. The radius of gyration of L-arabinose-binding protein decreases upon binding of ligand. The Journal of Biological Chemistry. 256: 13218-22. PMID 7031058 |
0.413 |
|
| 1981 |
Newcomer ME, Gilliland GL, Quiocho FA. L-Arabinose-binding protein-sugar complex at 2.4 A resolution. Stereochemistry and evidence for a structural change. The Journal of Biological Chemistry. 256: 13213-7. PMID 7031057 |
0.437 |
|
| 1981 |
Newcomer ME, Gilliland GL, Quiocho FA. L-Arabinose-binding protein-sugar complex at 2.4 A resolution. Stereochemistry and evidence for a structural change. The Journal of Biological Chemistry. 256: 13213-7. PMID 7031057 |
0.437 |
|
| 1980 |
Newcomer ME, Gilliland GL, Parish EJ, Schroepfer GJ, Quiocho FA. Concerning the structure of 7 alpha,15 beta-dichloro-5 alpha-cholest-8(14)-en-3 beta-ol, a novel inhibitor of cholesterol biosynthesis. Chemistry and Physics of Lipids. 26: 249-58. PMID 7371118 DOI: 10.1016/0009-3084(80)90055-9 |
0.326 |
|
| 1980 |
Newcomer ME, Gilliland GL, Parish EJ, Schroepfer GJ, Quiocho FA. Concerning the structure of 7 alpha,15 beta-dichloro-5 alpha-cholest-8(14)-en-3 beta-ol, a novel inhibitor of cholesterol biosynthesis. Chemistry and Physics of Lipids. 26: 249-58. PMID 7371118 DOI: 10.1016/0009-3084(80)90055-9 |
0.326 |
|
| 1979 |
Newcomer ME, Miller DM, Quiocho FA. Location of the sugar-binding site of L-arabinose-binding protein. Sugar derivative syntheses, sugar binding specificity, and difference Fourier analyses. The Journal of Biological Chemistry. 254: 7529-33. PMID 381285 |
0.447 |
|
| 1979 |
Newcomer ME, Miller DM, Quiocho FA. Location of the sugar-binding site of L-arabinose-binding protein. Sugar derivative syntheses, sugar binding specificity, and difference Fourier analyses. The Journal of Biological Chemistry. 254: 7529-33. PMID 381285 |
0.447 |
|
| 1979 |
Miller DM, Newcomer ME, Quiocho FA. The thiol group of the L-arabinose-binding protein. Chromophoric labeling and chemical identification of the sugar-binding site. The Journal of Biological Chemistry. 254: 7521-8. PMID 38241 |
0.391 |
|
| 1979 |
Miller DM, Newcomer ME, Quiocho FA. The thiol group of the L-arabinose-binding protein. Chromophoric labeling and chemical identification of the sugar-binding site. The Journal of Biological Chemistry. 254: 7521-8. PMID 38241 |
0.391 |
|
| 1978 |
Schroepfer GJ, Parish EJ, Gilliland GL, Newcomer ME, Sommerville LL, Quiocho FA, Kandutsch AA. 7alpha, 15beta-Dichloro-5alpha-cholest-8 (14)-en-3beta-ol, a novel inhibitor of sterol biosynthesis in animal cells. Biochemical and Biophysical Research Communications. 84: 823-9. PMID 718720 DOI: 10.1016/0006-291X(78)90778-7 |
0.319 |
|
| 1978 |
Schroepfer GJ, Parish EJ, Gilliland GL, Newcomer ME, Sommerville LL, Quiocho FA, Kandutsch AA. 7alpha, 15beta-Dichloro-5alpha-cholest-8 (14)-en-3beta-ol, a novel inhibitor of sterol biosynthesis in animal cells. Biochemical and Biophysical Research Communications. 84: 823-9. PMID 718720 DOI: 10.1016/0006-291X(78)90778-7 |
0.319 |
|
| 1978 |
Quiocho FA, Gilliland GL, Miller DM, Newcomer ME. Crystallographic and chemical studies of the L-arabinose-binding protein from E. coli Progress in Clinical and Biological Research. 333-348. |
0.404 |
|
| 1977 |
Quiocho FA, Gilliland GL, Miller DM, Newcomer ME. Crystallographic and chemical studies of the L-arabinose-binding protein from E. coli. Journal of Supramolecular Structure. 6: 503-18. PMID 338996 DOI: 10.1002/jss.400060405 |
0.404 |
|
| 1977 |
Quiocho FA, Gilliland GL, Miller DM, Newcomer ME. Crystallographic and chemical studies of the L-arabinose-binding protein from E. coli. Journal of Supramolecular Structure. 6: 503-18. PMID 338996 DOI: 10.1002/jss.400060405 |
0.404 |
|
| 1977 |
Gilliland GL, Newcomer ME, Parish EJ, Schroepfer GJ, Quiocho FA. Crystal structure and synthesis of 5α,14β-cholest-7-ene-3β,l5β-diol di-p-bromobenzoate Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 33: 3117-3121. DOI: 10.1107/S0567740877010371 |
0.343 |
|
| 1976 |
Parish EJ, Newcomer ME, Gilliland GL, Quiocho FA, Schroepfer GJ. Synthesis and structure of 15-oxygenated 5α,14β-cholest-7-en-3β-ol derivatives Tetrahedron Letters. 17: 4401-4404. DOI: 10.1016/0040-4039(76)80127-X |
0.312 |
|
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