| Year |
Citation |
Score |
| 2009 |
Hillmann P, Ko GY, Spinrath A, Raulf A, Von Kügelgen I, Wolff SC, Nicholas RA, Kostenis E, Höltje HD, Müller CE. Key determinants of nucleotide-activated G protein-coupled P2Y2 receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling Journal of Medicinal Chemistry. 52: 2762-2775. PMID 19419204 DOI: 10.1021/Jm801442P |
0.369 |
|
| 2008 |
Thielmann Y, Mohrlüder J, Koenig BW, Stangler T, Hartmann R, Becker K, Höltje HD, Willbold D. An indole-binding site is a major determinant of the ligand specificity of the GABA type A receptor-associated protein GABARAP Chembiochem. 9: 1767-1775. PMID 18567048 DOI: 10.1002/cbic.200800117 |
0.326 |
|
| 2007 |
Schlegel B, Laggner C, Meier R, Langer T, Schnell D, Seifert R, Stark H, Höltje HD, Sippl W. Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening Journal of Computer-Aided Molecular Design. 21: 437-453. PMID 17668276 DOI: 10.1007/S10822-007-9127-X |
0.556 |
|
| 2005 |
Schlegel B, Sippl W, Höltje HD. Molecular dynamics simulations of bovine rhodopsin: Influence of protonation states and different membrane-mimicking environments Journal of Molecular Modeling. 12: 49-64. PMID 16247601 DOI: 10.1007/S00894-005-0004-Z |
0.458 |
|
| 2005 |
Schlegel B, Stark H, Sippl W, Höltje HD. Model of a specific human histamine H3 receptor (hH 3R) binding pocket suitable for virtual drug design Inflammation Research. 54: S50-S51. PMID 15928832 DOI: 10.1007/S00011-004-0423-9 |
0.546 |
|
| 2005 |
Jöhren K, Höltje HD. Different environments for a realistic simulation of GPCRs-application to the M2 muscarinic receptor Archiv Der Pharmazie. 338: 260-267. PMID 15924369 DOI: 10.1002/ardp.200400992 |
0.346 |
|
| 2005 |
Terzioglu N, Höltje HD. Receptor-based 3D QSAR analysis of serotonin 5-HT1D receptor agonists Collection of Czechoslovak Chemical Communications. 70: 1482-1492. DOI: 10.1135/cccc20051482 |
0.318 |
|
| 2003 |
Bröer BM, Gurrath M, Höltje HD. Molecular modelling studies on the ORL1-receptor and ORL1-agonists Journal of Computer-Aided Molecular Design. 17: 739-754. PMID 15072434 DOI: 10.1023/B:JCAM.0000017491.97244.69 |
0.463 |
|
| 2003 |
Hammer S, Spika I, Sippl W, Jessen G, Kleuser B, Höltje HD, Schäfer-Korting M. Glucocorticoid receptor interactions with glucocorticoids: Evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants Steroids. 68: 329-339. PMID 12787894 DOI: 10.1016/S0039-128X(03)00030-8 |
0.565 |
|
| 2002 |
Jöhren K, Höltje HD. A model of the human M2 muscarinic acetylcholine receptor Journal of Computer-Aided Molecular Design. 16: 795-801. PMID 12825791 DOI: 10.1023/A:1023880611709 |
0.391 |
|
| 2002 |
Stoll F, Liesener S, Hohlfeld T, Schrör K, Fuchs PL, Höltje HD. Pharmacophore definition and three-dimensional quantitative structure-activity relationship study on structurally diverse prostacyclin receptor agonists. Molecular Pharmacology. 62: 1103-11. PMID 12391273 DOI: 10.1124/mol.62.5.1103 |
0.379 |
|
| 2002 |
Iadanza M, Höltje M, Ronsisvalle G, Höltje HD. κ-opioid receptor model in a phospholipid bilayer: Molecular dynamics simulation Journal of Medicinal Chemistry. 45: 4838-4846. PMID 12383009 DOI: 10.1021/jm0209127 |
0.407 |
|
| 2000 |
Cinone N, Höltje HD, Carotti A. Development of a unique 3D interaction model of endogenous and synthetic peripheral benzodiazepine receptor ligands Journal of Computer-Aided Molecular Design. 14: 753-768. PMID 11131968 DOI: 10.1023/A:1008168127539 |
0.4 |
|
| 2000 |
Sippl W, Höltje HD. Structure-based 3D-QSAR - Merging the accuracy of structure-based alignments with the computational efficiency of ligand-based methods Journal of Molecular Structure: Theochem. 503: 31-50. DOI: 10.1016/S0166-1280(99)00361-9 |
0.513 |
|
| 1999 |
Gysler A, Kleuser B, Sippl W, Lange K, Korting HC, Höltje HD, Schäfer-Korting M. Skin penetration and metabolism of topical glucocorticoids in reconstructed epidermis and in excised human skin Pharmaceutical Research. 16: 1386-1391. PMID 10496654 DOI: 10.1023/A:1018946924585 |
0.392 |
|
| 1998 |
Schleifer KJ, Tot E, Höltje HD. Pharmacophore and pseudoreceptor modelling of class Ib antiarrhythmic and local anaesthetic lidocaine analogues Pharmazie. 53: 596-602. PMID 9770207 |
0.313 |
|
| 1998 |
Sippl W, Stark H, Höltje HD. Development of a binding site model for histamine H3-receptor agonists Pharmazie. 53: 433-437. PMID 9699219 |
0.506 |
|
| 1998 |
Sippl W, Stark H, Höltje HD. Development of a binding site model for histamine H3-receptor agonists Pharmazie. 53: 433-437. PMID 9699219 |
0.597 |
|
| 1997 |
Höltje HD, Sippl W. Molecular modelling studies on histamine H2- and H3-receptor agonists Pharmacochemistry Library. 28: 137-148. DOI: 10.1016/S0165-7208(97)80060-8 |
0.569 |
|
| 1997 |
Höltje HD, Sippl W. Molecular modelling studies on histamine H2- and H3-receptor agonists Pharmacochemistry Library. 28: 137-148. DOI: 10.1016/S0165-7208(97)80060-8 |
0.423 |
|
| 1995 |
Höltje HD, Jendretzki UK. Construction of a detailed serotoninergic 5-HT2a receptor model. Archiv Der Pharmazie. 328: 577-84. PMID 7492262 |
0.35 |
|
| 1995 |
Sippl W, Stark H, Holtje HD. Computer-assisted analysis of histamine H2- and H3-receptor agonists Quantitative Structure-Activity Relationships. 14: 121-125. DOI: 10.1002/Qsar.19950140203 |
0.59 |
|
| 1994 |
Sippl W, Höltje HD. P81 sterical and electronical properties of histamine H2-agonists European Journal of Pharmaceutical Sciences. 2: 139. DOI: 10.1016/0928-0987(94)90254-2 |
0.435 |
|
| 1993 |
Höltje HD, Dall N. A molecular modelling study on the hormone binding site of the estrogen receptor. Die Pharmazie. 48: 243-9. PMID 8391709 |
0.351 |
|
| 1993 |
Höltje HD. [Molecular modelling studies on hormone binding regulation by estrogen receptors]. Archiv Der Pharmazie. 326: 765-8. PMID 8267512 |
0.346 |
|
| 1990 |
Höltje HD, Batzenschlager A. Conformational analyses on histamine H2-receptor antagonists. Journal of Computer-Aided Molecular Design. 4: 391-402. PMID 1982629 |
0.421 |
|
| 1989 |
Höltje HD. Molecular modelling of the interaction of dihydropyridine drugs with their receptors. Progress in Clinical and Biological Research. 291: 237-41. PMID 2542977 |
0.349 |
|
| 1987 |
Höltje HD, Adler P. [Theoretical research on the interaction between drugs and receptor models. VIII. An interaction model for the binding of sulfonamides on human serum albumin]. Archiv Der Pharmazie. 320: 234-40. PMID 3579525 |
0.33 |
|
| 1986 |
Höltje HD. [Molecular modeling of the structure of barbiturate receptors]. Archiv Der Pharmazie. 319: 570-2. PMID 3017268 DOI: 10.1002/ARDP.19863190617 |
0.38 |
|
| 1986 |
Tintelnot M, Höltje HD. Conformational studies on histamine H2-receptor antagonists: deduction of a simple structure-activity relationship Journal of Molecular Graphics. 4: 7-11. DOI: 10.1016/0263-7855(86)80087-X |
0.409 |
|
| 1985 |
Höltje HD, Baranowski P, Spengler JP, Schunack W. [A binding-site model for H2-antagonists of the 4-pyrimidinone type]. Archiv Der Pharmazie. 318: 542-8. PMID 2862855 |
0.334 |
|
| 1983 |
Höltje HD, Baranowski P. [Theoretical investigations of interactions between drugs and models of receptor sites, 3: induced fit interactions of verapamil derivatives]. Archiv Der Pharmazie. 316: 154-60. PMID 6847345 |
0.305 |
|
| 1979 |
Höltje HD. [Theoretical studies on drug-receptor model complexes]. Pharmaceutica Acta Helvetiae. 54: 125-34. PMID 386361 |
0.301 |
|
| 1978 |
Höltje HD. [Theoretical studies on interactions between pharmacon models and ionic receptor binding sites (author's transl)]. Archiv Der Pharmazie. 311: 2-11. PMID 626563 |
0.348 |
|
| 1975 |
Kier LB, Höltje HD. A stochastic model of the remote recognition of preferred conformation in a drug-receptor interaction. Journal of Theoretical Biology. 49: 401-16. PMID 1121187 DOI: 10.1016/0022-5193(75)90181-2 |
0.341 |
|
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