Howard S. Tager - Related publications

Biochemistry & Molecular Biology University of Chicago, Chicago, IL 
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Gençoğlu H, Şahin K, Jones PM. Determining the insulin secretion potential for certain specific G-protein coupled receptors in MIN6 pancreatic beta cells Turkish Journal of Medical Sciences. 49: 403-411. PMID 30761839 DOI: 10.3906/sag-1712-147   
2019 Shirinfar B, Ahmed N. Diabetes Treatment: Selective Synthetic Receptor for Glucose. Chemistryopen. 8: 84-86. PMID 30693171 DOI: 10.1002/open.201800279   
2019 Csajbók ÉA, Kocsis ÁK, Faragó N, Furdan S, Kovács B, Lovas S, Molnár G, Likó I, Zvara Á, Puskás LG, Patócs A, Tamás G. Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex. Diabetologia. PMID 30637442 DOI: 10.1007/s00125-018-4803-z   
2019 Hussein H, Zaccardi F, Khunti K, Seidu S, Davies MJ, Gray LJ. Cardiovascular efficacy and safety of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists: a systematic review and network meta-analysis. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 30653708 DOI: 10.1111/dme.13898   
2019 Boye KS, Riddle MC, Gerstein HC, Mody R, Garcia-Perez LE, Karanikas CA, Lage MJ, Riesmeyer JS, Lakshmanan MC. Generalizability of Glucagon-Like Peptide-1 Receptor Agonist Cardiovascular Outcome Trials to the Overall Type 2 Diabetes Population in the United States. Diabetes, Obesity & Metabolism. PMID 30714309 DOI: 10.1111/dom.13649   
2019 Subiabre M, Villalobos-Labra R, Silva L, Fuentes G, Toledo F, Sobrevia L. Role of insulin, adenosine, and adipokine receptors in the foetoplacental vascular dysfunction in gestational diabetes mellitus. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 30660686 DOI: 10.1016/j.bbadis.2018.12.021   
2019 Jones KL, Rigda RS, Buttfield MD, Hatzinikolas S, Pham HT, Marathe CS, Wu T, Lange K, Trahair LG, Rayner CK, Horowitz M. Effects of lixisenatide on postprandial blood pressure, gastric emptying and glycemia in health and type 2 diabetes. Diabetes, Obesity & Metabolism. PMID 30623563 DOI: 10.1111/dom.13633   
2019 Willars GB, Lu J. Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation. The Biochemical Journal. PMID 30626614 DOI: 10.1042/BCJ20180853   
2019 Zhou X, Xu C, Zou Z, Shen X, Xie T, Zhang R, Liao L, Dong J. aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model. Molecular Medicine (Cambridge, Mass.). 25: 2. PMID 30616503 DOI: 10.1186/s10020-018-0067-9   
2019 Zha D, Yao T, Bao L, Gao P, Wu X. Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1. Life Sciences. PMID 30699330 DOI: 10.1016/j.lfs.2019.01.044   
2019 Lenaerts C, Marchal E, Peeters P, Vanden Broeck J. The ecdysone receptor complex is essential for the reproductive success in the female desert locust, Schistocerca gregaria. Scientific Reports. 9: 15. PMID 30626886 DOI: 10.1038/s41598-018-36763-9   
2019 Fischer JP, Schönauer R, Els-Heindl S, Bierer D, Koebberling J, Riedl B, Beck-Sickinger AG. Adrenomedullin disulfide bond mimetics uncover structural requirements for AM receptor activation. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3147. PMID 30680847 DOI: 10.1002/psc.3147   
2019 Wang JH, Li HZ, Shao XX, Nie WH, Liu YL, Xu ZG, Guo ZY. Identifying the binding mechanism of LEAP2 to receptor GHSR1a. The Febs Journal. PMID 30666806 DOI: 10.1111/febs.14763   
2019 Bergmann NC, Lund A, Gasbjerg LS, Meessen ECE, Andersen MM, Bergmann S, Hartmann B, Holst JJ, Jessen L, Christensen MB, Vilsbøll T, Knop FK. Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study. Diabetologia. PMID 30683945 DOI: 10.1007/s00125-018-4810-0   
2019 Rujan RM, Reynolds CA. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies. Handbook of Experimental Pharmacology. PMID 30689083 DOI: 10.1007/164_2018_173   
2019 Zhou Y, Wang Y, Zhang L, Tang C, Feng B. Discovery and biological evaluation of novel G protein-coupled receptor 119 agonists for type 2 diabetes. Archiv Der Pharmazie. e1800267. PMID 30740769 DOI: 10.1002/ardp.201800267   
2019 Wang JH, Nie WH, Shao XX, Li HZ, Hu MJ, Liu YL, Xu ZG, Guo ZY. Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay. Biochimica Et Biophysica Acta. Biomembranes. PMID 30684458 DOI: 10.1016/j.bbamem.2019.01.010   
2019 Hernandez-Reyes JE, Salinas-Abarca AB, Vidal-Cantu GC, Raya-Tafolla G, Elias-Viñas D, Granados-Soto V, Delgado-Lezama R. α5GABAA receptors play a pro-nociceptive role and avoid the rate dependent depression of the Hoffmann reflex in diabetic neuropathic pain and reduce primary afferent excitability. Pain. PMID 30720584 DOI: 10.1097/j.pain.0000000000001515   
2019 Kong D, Guo S, Yang Y, Guo B, Xie X, Hu W. Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine. Bioorganic & Medicinal Chemistry Letters. PMID 30685095 DOI: 10.1016/j.bmcl.2019.01.014   
2019 Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. The Journal of Clinical Endocrinology and Metabolism. PMID 30726969 DOI: 10.1210/jc.2018-02503   
2019 Li X, Zhang X, Pang L, Yao L, ShangGuan Z, Pan Y. Agaricus bisporus-derived β-glucan enter macrophages and adipocytes by CD36 receptor. Natural Product Research. 1-4. PMID 30676779 DOI: 10.1080/14786419.2018.1556654   
2019 Chepurny OG, Matsoukas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG. Non-conventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP. The Journal of Biological Chemistry. PMID 30622136 DOI: 10.1074/jbc.RA118.005682   
2019 Jean-Louis B, Blais VD, Holleran BJ, Bergeron A, Pineyro G, Guérin B, Gendron L, Dory YL. N-guanidyl and C-tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties. Acs Chemical Neuroscience. PMID 30614675 DOI: 10.1021/acschemneuro.8b00550   
2019 Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. PMID 30639100 DOI: 10.1016/j.cell.2018.12.006   
2019 Morgan ES, Tai LJ, Pham NC, Overman JK, Watts LM, Smith A, Jung SW, Gajdošík M, Krššák M, Krebs M, Geary RS, Baker BF, Bhanot S. Antisense Inhibition of Glucagon Receptor by IONIS-GCGR Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy. Diabetes Care. PMID 30765435 DOI: 10.2337/dc18-1343   
2019 Ritler A, Shoshan M, Deupi X, Wilhelm P, Schibli R, Wennemers H, Behe M. Elucidating the structure-activity relationship of the pentaglutamic acid sequence of minigastrin with the cholecystokinin receptor subtype 2. Bioconjugate Chemistry. PMID 30608664 DOI: 10.1021/acs.bioconjchem.8b00849   
2019 Modestia SM, Malta de Sá M, Auger E, Trossini GHG, Krieger JE, Rangel-Yagui CO. Biased Agonist TRV027 Determinants in AT1R by Molecular Dynamics Simulations. Journal of Chemical Information and Modeling. PMID 30668103 DOI: 10.1021/acs.jcim.8b00628   
2019 Perrault DP, Lee GK, Park SY, Lee S, Choi D, Jung E, Seong YJ, Park EK, Sung C, Yu R, Bouz A, Pourmoussa A, Kim SJ, Hong YK, Wong AK. Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis. Lymphatic Research and Biology. PMID 30648916 DOI: 10.1089/lrb.2018.0035   
2019 Rasaeifar B, Lupala CS, Gomez-Gutierrez P, Perez JJ. Molecular features characterizing non-peptide selectivity to the human B1 and B2 bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 29: 11-14. PMID 30466897 DOI: 10.1016/j.bmcl.2018.11.026   
2019 Mack SM, Gomes I, Devi LA. Neuropeptide PEN and its receptor GPR83; Distribution, Signaling and Regulation. Acs Chemical Neuroscience. PMID 30726666 DOI: 10.1021/acschemneuro.8b00559   
2019 Cai Y, Huang J, Xing H, Li B, Li L, Wang X, Peng D, Chen J. Contribution of FPR and TLR9 to hypoxia-induced chemoresistance of ovarian cancer cells. Oncotargets and Therapy. 12: 291-301. PMID 30643427 DOI: 10.2147/OTT.S190118   
2019 Elzinga D, Sternburg E, Sabbadin D, Bartsch M, Park SY, Vaidya A, Mosquna A, Kaundal A, Wendeborn S, Lachia M, Karginov FV, Cutler SR. Defining and Exploiting Hypersensitivity Hotspots to Facilitate Abscisic Acid Agonist Optimization. Acs Chemical Biology. PMID 30668093 DOI: 10.1021/acschembio.8b00955   
2019 Cha HJ, Song YJ, Lee DE, Kim YH, Shin J, Jang CG, Suh SK, Kim SJ, Yun J. Receptor Binding Affinities of Synthetic Cannabinoids Determined by Non-Isotopic Receptor Binding Assay. Toxicological Research. 35: 37-44. PMID 30766656 DOI: 10.5487/TR.2019.35.1.037   
2019 Jia K, Zhang D, Jia Q, Zhang QY. Regulation of Fgf15 expression in the intestine by glucocorticoid receptor. Molecular Medicine Reports. PMID 30720089 DOI: 10.3892/mmr.2019.9915   
2019 Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wüthrich K, Zhao Q. Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. Nature Communications. 10: 638. PMID 30733446 DOI: 10.1038/s41467-019-08568-5   
2019 Liu L, Panzitt K, Racedo S, Wagner M, Platzer W, Zaufel A, Theiler-Schwetz V, Obermayer-Pietsch B, Müller H, Höfler G, Heinemann A, Zollner G, Fickert P. Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1. Liver International : Official Journal of the International Association For the Study of the Liver. PMID 30664326 DOI: 10.1111/liv.14052   
2019 Liu L, Hu Y, Zhang S, Li X, Zhang J. Association of insulin-like growth factor 1 receptor and estrogen receptor with pathological complete response to neoadjuvant chemotherapy in HER2-negative breast cancer. Breast Cancer (Tokyo, Japan). PMID 30617938 DOI: 10.1007/s12282-018-00939-y   
2019 Yang P, Read C, Kuc RE, Nyimanu D, Williams TL, Crosby A, Buonincontri G, Southwood M, Sawiak SJ, Morrell NW, Davenport AP, Maguire JJ. A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. British Journal of Pharmacology. PMID 30710493 DOI: 10.1111/bph.14603   
2019 Shah UH, Gaitonde SA, Moreno JL, Glennon RA, Dukat M, González-Maeso J. A revised pharmacophore model for 5-HT2A receptor antagonists derived from the atypical antipsychotic agent risperidone. Acs Chemical Neuroscience. PMID 30609893 DOI: 10.1021/acschemneuro.8b00637   
2019 Jansen HJ, Mackasey M, Moghtadaei M, Liu Y, Kaur J, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice. Circulation. Arrhythmia and Electrophysiology. 12: e006863. PMID 30636477 DOI: 10.1161/CIRCEP.118.006863   
2019 McGraw C, Yang L, Levental I, Lyman E, Skaja-Robinson A. Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A receptor. Biochimica Et Biophysica Acta. Biomembranes. PMID 30629951 DOI: 10.1016/j.bbamem.2019.01.001   
2019 Fargher HA, Lau N, Zakharov LN, Haley MM, Johnson DW, Pluth MD. Expanding reversible chalcogenide binding: supramolecular receptors for the hydroselenide (HSe) anion. Chemical Science. 10: 67-72. PMID 30746074 DOI: 10.1039/c8sc03968b   
2019 Müskens FM, Ward RJ, Herkt D, van de Langemheen H, Tobin AB, Liskamp RMJ, Milligan G. Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors. Molecular Pharmacology. 95: 196-209. PMID 30514721 DOI: 10.1124/mol.118.114249   
2019 Deng SJ, Alabi A, Gu HM, Adijiang A, Qin S, Zhang DW. Identification of amino acid residues in the ligand binding repeats of LDLR important for PCSK9 binding. Journal of Lipid Research. PMID 30617148 DOI: 10.1194/jlr.M089193   
2019 Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. PMID 30639099 DOI: 10.1016/j.cell.2018.12.005   
2019 Igawa T, Kishikawa S, Abe Y, Yamashita T, Nagai S, Shiroishi M, Shinozaki C, Tanaka H, Tozaki-Saitoh H, Tsuda M, Inoue K, Ueda T. Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure. Purinergic Signalling. PMID 30684150 DOI: 10.1007/s11302-019-09646-5   
2019 Taylor ME, Drickamer K. Mammalian sugar-binding receptors: known functions and unexplored roles. The Febs Journal. PMID 30657247 DOI: 10.1111/febs.14759   
2019 Reinscheid RK, Civelli O. The History of N/OFQ and the NOP Receptor. Handbook of Experimental Pharmacology. PMID 30689090 DOI: 10.1007/164_2018_195   
2019 Cataldo Bascuñan LR, Lyons C, Bennet H, Artner I, Fex M. Serotonergic regulation of insulin secretion. Acta Physiologica (Oxford, England). 225: e13101. PMID 29791774 DOI: 10.1111/apha.13101   
2019 Czarnecka M, Lu C, Pons J, Maheswaran I, Ciborowski P, Zhang L, Cheema A, Kitlinska J. Neuropeptide Y receptor interactions regulate its mitogenic activity. Neuropeptides. 73: 11-24. PMID 30503694 DOI: 10.1016/j.npep.2018.11.008