Stephen Hill - Publications

Affiliations: 
University of Bristol, Bristol, England, United Kingdom 

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kok ZY, Stoddart LA, Mistry SJ, Mocking TAM, Vischer HF, Leurs R, Hill SJ, Mistry SN, Kellam B. Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H Receptor. Journal of Medicinal Chemistry. 65: 8258-8288. PMID 35734860 DOI: 10.1021/acs.jmedchem.2c00125  0.813
2022 Wragg ES, Pannucci P, Hill SJ, Woolard J, Cooper SL. Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A and A receptor agonists. Pharmacology Research & Perspectives. 10: e00975. PMID 35643970 DOI: 10.1002/prp2.975  0.333
2022 Cooper SL, Wragg ES, Pannucci P, Soave M, Hill SJ, Woolard J. Regionally selective cardiovascular responses to adenosine A and A receptor activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 36: e22214. PMID 35230706 DOI: 10.1096/fj.202101945R  0.356
2022 Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov K, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, et al. Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX. British Journal of Pharmacology. PMID 35106752 DOI: 10.1111/bph.15811  0.401
2021 Kilpatrick LE, Hill SJ. The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update. Biochemical Society Transactions. 49: 1547-1554. PMID 34436556 DOI: 10.1042/BST20201001  0.449
2021 Trinh PNH, Chong DJW, Leach K, Hill SJ, Tyndall JDA, May LT, Vernall AJ, Gregory KJ. Development of Covalent, Clickable Probes for Adenosine A and A Receptors. Journal of Medicinal Chemistry. PMID 34120444 DOI: 10.1021/acs.jmedchem.0c02169  0.496
2021 Goulding J, Mistry SJ, Soave M, Woolard J, Briddon SJ, White CW, Kellam B, Hill SJ. Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2-adrenoceptor in CRISPR/Cas9 genome-edited HEK293T cells at low expression levels. Pharmacology Research & Perspectives. 9: e00779. PMID 34003582 DOI: 10.1002/prp2.779  0.693
2021 Kilpatrick LE, Hill SJ. Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies. Current Opinion in Endocrine and Metabolic Research. 16: 102-112. PMID 33748531 DOI: 10.1016/j.coemr.2020.10.003  0.423
2021 Comeo E, Trinh P, Nguyen AT, Nowell CJ, Kindon ND, Soave M, Stoddart LA, White JM, Hill SJ, Kellam B, Halls ML, May LT, Scammells PJ. Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A Receptor in Living Cells. Journal of Medicinal Chemistry. PMID 33724031 DOI: 10.1021/acs.jmedchem.0c02067  0.795
2021 Stoddart LA, Kilpatrick LE, Corriden R, Kellam B, Briddon SJ, Hill SJ. Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21211. PMID 33710641 DOI: 10.1096/fj.202001729RR  0.709
2021 Mai QN, Shenoy P, Quach T, Retamal JS, Gondin AB, Yeatman HR, Aurelio L, Conner JW, Poole DP, Canals M, Nowell CJ, Graham B, Davis TP, Briddon SJ, Hill SJ, et al. A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes. The Journal of Biological Chemistry. 100345. PMID 33515548 DOI: 10.1016/j.jbc.2021.100345  0.324
2021 Soave M, Stoddart LA, White CW, Kilpatrick LE, Goulding J, Briddon SJ, Hill SJ. Detection of Genome-Edited and Endogenously Expressed G Protein-Coupled Receptors. The Febs Journal. PMID 33506623 DOI: 10.1111/febs.15729  0.419
2021 Johnstone EKM, See HB, Abhayawardana RS, Song A, Rosengren KJ, Hill SJ, Pfleger KDG. Investigation of Receptor Heteromers Using NanoBRET Ligand Binding. International Journal of Molecular Sciences. 22. PMID 33499147 DOI: 10.3390/ijms22031082  0.475
2021 White CW, Kilpatrick LE, Pfleger KDG, Hill SJ. A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding. Iscience. 24: 102011. PMID 33490919 DOI: 10.1016/j.isci.2020.102011  0.405
2020 Stoddart LA, Kindon ND, Otun O, Harwood CR, Patera F, Veprintsev DB, Woolard J, Briddon SJ, Franks HA, Hill SJ, Kellam B. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells. Communications Biology. 3: 722. PMID 33247190 DOI: 10.1038/s42003-020-01451-w  0.739
2020 Baker JG, Fromont C, Bruder M, Thompson KSJ, Kellam B, Hill SJ, Gardiner SM, Fischer PM. Using Esterase Selectivity to Determine the Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers. Acs Pharmacology & Translational Science. 3: 737-748. PMID 32832874 DOI: 10.1021/acsptsci.0c00051  0.572
2020 Soave M, Heukers R, Kellam B, Woolard J, Smit MJ, Briddon SJ, Hill SJ. Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies. Cell Chemical Biology. PMID 32610042 DOI: 10.1016/J.Chembiol.2020.06.006  0.691
2020 Perpina-Viciano C, Isbilir A, Zarca A, Caspar B, Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C. Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4. Molecular Pharmacology. PMID 32474443 DOI: 10.1124/Mol.119.118448  0.397
2020 Grime RL, Goulding J, Uddin R, Stoddart LA, Hill SJ, Poyner DR, Briddon SJ, Wheatley M. Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles. Nanoscale. PMID 32428052 DOI: 10.1039/D0Nr01060J  0.427
2020 Robers MB, Friedman-Ohana R, Huber K, Kilpatrick L, Vasta JD, Berger BT, Chaudhry C, Hill S, Müller S, Knapp S, Wood KV. Quantifying Target Occupancy of Small Molecules Within Living Cells. Annual Review of Biochemistry. PMID 32208767 DOI: 10.1146/Annurev-Biochem-011420-092302  0.346
2020 White CW, Caspar B, Vanyai HK, Pfleger KDG, Hill SJ. CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes. Cell Chemical Biology. PMID 32053779 DOI: 10.1016/J.Chembiol.2020.01.010  0.422
2020 Soave M, Goulding J, Markus R, Hill SJ, Stoddart LA. Application of Fluorescent Purinoceptor Antagonists for Bioluminescence Resonance Energy Transfer Assays and Fluorescent Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2041: 163-181. PMID 31646488 DOI: 10.1007/978-1-4939-9717-6_12  0.489
2020 Cooper SL, Wragg E, March J, Hill S, Woolard J. Effects of an Adenosine Receptor Bitopic Ligand on The Cardiovascular System The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02426  0.517
2019 Comeo E, Kindon ND, Soave M, Stoddart LA, Kilpatrick L, Scammells PJ, Hill SJ, Kellam B. Subtype-selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor. Journal of Medicinal Chemistry. PMID 31887252 DOI: 10.1021/Acs.Jmedchem.9B01856  0.804
2019 Soave M, Briddon SJ, Hill SJ, Stoddart LA. Fluorescent ligands: Bringing light to emerging G protein-coupled receptor paradigms. British Journal of Pharmacology. PMID 31877233 DOI: 10.1111/bph.14953  0.471
2019 Cooper SL, March J, Sabbatini AR, Hill SJ, Jörg M, Scammells PJ, Woolard J. The effect of two selective A -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats. British Journal of Pharmacology. PMID 31596949 DOI: 10.1111/Bph.14870  0.646
2019 Soave M, Kellam B, Woolard J, Briddon SJ, Hill SJ. NanoBiT Complementation to Monitor Agonist-Induced Adenosine A Receptor Internalization. Slas Discovery : Advancing Life Sciences R & D. 2472555219880475. PMID 31583945 DOI: 10.1177/2472555219880475  0.746
2019 Adlere I, Caspar B, Arimont M, Dekkers S, Visser K, Stuijt J, de Graaf C, Stocks M, Kellam B, Briddon S, Wijtmans M, de Esch I, Hill S, Leurs R. Modulators of CXCR4 and CXCR7/ACKR3 function. Molecular Pharmacology. PMID 31548340 DOI: 10.1124/Mol.119.117663  0.745
2019 Peach CJ, Kilpatrick LE, Woolard J, Hill SJ. Comparison of the ligand binding properties of fluorescent VEGF-A isoforms to VEGFR2 in living cells and membrane preparations using NanoBRET. British Journal of Pharmacology. PMID 31162634 DOI: 10.1111/Bph.14755  0.312
2019 Bosma R, Stoddart LA, Georgi V, Bouzo-Lorenzo M, Bushby N, Inkoom L, Waring MJ, Briddon SJ, Vischer HF, Sheppard RJ, Fernández-Montalván A, Hill SJ, Leurs R. Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor. Scientific Reports. 9: 7906. PMID 31133718 DOI: 10.1038/S41598-019-44025-5  0.38
2019 Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C. Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3). Molecular Pharmacology. PMID 31092552 DOI: 10.1124/Mol.118.115477  0.363
2019 Bouzo-Lorenzo M, Stoddart LA, Xia L, IJzerman AP, Heitman LH, Briddon SJ, Hill SJ. A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A receptor. Purinergic Signalling. PMID 30919204 DOI: 10.1007/S11302-019-09650-9  0.46
2019 Sykes DA, Stoddart LA, Kilpatrick LE, Hill SJ. Binding kinetics of ligands acting at GPCRs. Molecular and Cellular Endocrinology. PMID 30738950 DOI: 10.1016/J.Mce.2019.01.018  0.375
2019 Cooper SL, Soave M, Jörg M, Scammells PJ, Woolard J, Hill SJ. Probe dependence of allosteric enhancers on the binding affinity of adenosine A -receptor agonists at rat and human A -receptors measured using NanoBRET. British Journal of Pharmacology. PMID 30644086 DOI: 10.1111/Bph.14575  0.683
2019 Chazot P, Cowart M, Fukui H, Ganellin CR, Gutzmer R, Haas HL, Hill SJ, Hills R, Leurs R, Levi R, Liu S, Panula P, Schunack W, Schwartz J, Seifert R, et al. Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f33/2019.4  0.332
2018 Singh S, Cooper SL, Glenn JR, Beresford J, Percival LR, Tyndall JDA, Hill SJ, Kilpatrick LE, Vernall AJ. Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools. Rsc Advances. 8: 16362-16369. PMID 35542203 DOI: 10.1039/c7ra13148h  0.5
2018 Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano Perpiñá C, Caspar B, Arimont M, Bebelman JP, Briddon SJ, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, et al. Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. European Journal of Medicinal Chemistry. 162: 631-649. PMID 30476826 DOI: 10.1016/J.Ejmech.2018.10.060  0.363
2018 Alcobia DC, Ziegler AI, Kondrashov A, Comeo E, Mistry S, Kellam B, Chang A, Woolard J, Hill SJ, Sloan EK. Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET. Iscience. 6: 280-288. PMID 30240618 DOI: 10.1016/J.Isci.2018.08.006  0.633
2018 Peach CJ, Kilpatrick LE, Friedman-Ohana R, Zimmerman K, Robers MB, Wood KV, Woolard J, Hill SJ. Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells. Cell Chemical Biology. PMID 30057299 DOI: 10.1016/J.Chembiol.2018.06.012  0.344
2018 Conroy S, Kindon ND, Glenn J, Stoddart LA, Lewis RJ, Hill SJ, Kellam B, Stocks MJ. Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y Receptor Based on AR-C118925. Journal of Medicinal Chemistry. PMID 29688707 DOI: 10.1021/Acs.Jmedchem.8B00606  0.708
2018 Conroy S, Kindon ND, Glenn J, Stoddart LA, Lewis RJ, Hill SJ, Kellam B, Stocks MJ. Synthesis and Evaluation of the first Fluorescent Antagonists of the Human P2YReceptor based on AR-C118925. Journal of Medicinal Chemistry. PMID 29558126 DOI: 10.1021/Acs.Jmedchem.8B00139  0.745
2018 Stoddart LA, Vernall AJ, Bouzo-Lorenzo M, Bosma R, Kooistra AJ, de Graaf C, Vischer HF, Leurs R, Briddon SJ, Kellam B, Hill SJ. Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells. Scientific Reports. 8: 1572. PMID 29371669 DOI: 10.1038/S41598-018-19714-2  0.753
2017 Arruda MA, Stoddart LA, Gherbi K, Briddon SJ, Kellam B, Hill SJ. A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells. Frontiers in Pharmacology. 8: 908. PMID 29321740 DOI: 10.3389/Fphar.2017.00908  0.734
2017 Briddon SJ, Kilpatrick LE, Hill SJ. Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age. Trends in Pharmacological Sciences. PMID 29277246 DOI: 10.1016/J.Tips.2017.11.004  0.444
2017 Stoddart LA, Kilpatrick LE, Hill SJ. NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs. Trends in Pharmacological Sciences. PMID 29132917 DOI: 10.1016/J.Tips.2017.10.006  0.516
2017 Goulding J, May LT, Hill SJ. Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: Evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603. Biochemical Pharmacology. PMID 29106905 DOI: 10.1016/J.Bcp.2017.10.013  0.352
2017 Soave M, Cseke G, Hutchings CJ, Brown AJH, Woolard J, Hill SJ. A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines. Biochemical Pharmacology. PMID 29102678 DOI: 10.1016/J.Bcp.2017.10.015  0.329
2017 Baker JG, Gardiner SM, Woolard J, Fromont C, Jadhav GP, Mistry SN, Thompson KS, Kellam B, Hill SJ, Fischer PM. Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28400472 DOI: 10.1096/Fj.201601305R  0.754
2017 Kilpatrick LE, Friedman-Ohana R, Alcobia DC, Riching K, Peach CJ, Wheal AJ, Briddon SJ, Robers MB, Zimmerman K, Machleidt T, Wood KV, Woolard J, Hill SJ. Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes. Biochemical Pharmacology. PMID 28392095 DOI: 10.1016/J.Bcp.2017.04.006  0.357
2016 Hothersall JD, Guo D, Sarda S, Sheppard RJ, Chen H, Keur W, Waring MJ, IJzerman AP, Hill SJ, Dale IL, Rawlins P. Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics. Molecular Pharmacology. PMID 27803241 DOI: 10.1124/Mol.116.105551  0.412
2016 Soave M, Stoddart LA, Brown A, Woolard J, Hill SJ. Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β 1-adrenoceptor expressed in HEK-293 cells. Pharmacology Research & Perspectives. 4: e00250. PMID 27588207 DOI: 10.1002/Prp2.250  0.415
2016 Kilpatrick LE, Hill SJ. The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors. Biochemical Society Transactions. 44: 624-9. PMID 27068980 DOI: 10.1042/Bst20150285  0.448
2015 Ranganathan A, Stoddart LA, Hill SJ, Carlsson J. Fragment-based discovery of subtype selective adenosine receptor ligands from homology models. Journal of Medicinal Chemistry. PMID 26592528 DOI: 10.1021/Acs.Jmedchem.5B01120  0.457
2015 Stoddart LA, White CW, Nguyen K, Hill SJ, Pfleger KD. Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding. British Journal of Pharmacology. PMID 26317175 DOI: 10.1111/Bph.13316  0.454
2015 Hoffmann C, Castro M, Rinken A, Leurs R, Hill SJ, Vischer HF. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It. Molecular Pharmacology. 88: 552-60. PMID 26152198 DOI: 10.1124/Mol.115.099671  0.323
2015 Stoddart LA, Johnstone EK, Wheal AJ, Goulding J, Robers MB, Machleidt T, Wood KV, Hill SJ, Pfleger KD. Application of BRET to monitor ligand binding to GPCRs. Nature Methods. 12: 661-3. PMID 26030448 DOI: 10.1038/Nmeth.3398  0.391
2015 Stoddart LA, Kilpatrick LE, Briddon SJ, Hill SJ. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands. Neuropharmacology. 98: 48-57. PMID 25979488 DOI: 10.1016/J.Neuropharm.2015.04.033  0.532
2015 van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ. A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms. Molecular Pharmacology. 88: 589-95. PMID 25972446 DOI: 10.1124/Mol.115.098897  0.315
2015 Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 98: 68-77. PMID 25937210 DOI: 10.1016/J.Neuropharm.2015.04.013  0.715
2015 Hill S. Investigation of GPCR allosterism and dimerization in single living cells using fluorescent ligands Springerplus. 4: 1-32. DOI: 10.1186/2193-1801-4-S1-L8  0.402
2015 Hill SR, Majeed S, Ignell R. Molecular basis for odorant receptor tuning: A short C-terminal sequence is necessary and sufficient for selectivity of mosquito Or8 Insect Molecular Biology. 24: 491-501. DOI: 10.1111/Imb.12176  0.306
2015 Stoddart LA, Kilpatrick LE, Briddon SJ, Hill SJ. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands Neuropharmacology. DOI: 10.1016/j.neuropharm.2015.04.033  0.458
2014 Gherbi K, Briddon SJ, Hill SJ. Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. British Journal of Pharmacology. 171: 5431-45. PMID 25052258 DOI: 10.1111/Bph.12858  0.332
2014 Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4211-22. PMID 24970394 DOI: 10.1096/Fj.13-247270  0.713
2014 Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology. 171: 3827-44. PMID 24750014 DOI: 10.1111/Bph.12739  0.687
2014 Jaeger WC, Armstrong SP, Hill SJ, Pfleger KD. Biophysical Detection of Diversity and Bias in GPCR Function. Frontiers in Endocrinology. 5: 26. PMID 24634666 DOI: 10.3389/Fendo.2014.00026  0.396
2014 Hutchings CJ, Cseke G, Osborne G, Woolard J, Zhukov A, Koglin M, Jazayeri A, Pandya-Pathak J, Langmead CJ, Hill SJ, Weir M, Marshall FH. Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment. Mabs. 6: 246-61. PMID 24253107 DOI: 10.4161/Mabs.27226  0.329
2014 Hill SJ, May LT, Kellam B, Woolard J. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. British Journal of Pharmacology. 171: 1102-13. PMID 24024783 DOI: 10.1111/Bph.12345  0.714
2014 Vernall AJ, Hill SJ, Kellam B. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. British Journal of Pharmacology. 171: 1073-84. PMID 23734587 DOI: 10.1111/Bph.12265  0.694
2013 Baker JG, Proudman RG, Hill SJ. Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor. Plos One. 8: e77582. PMID 24250787 DOI: 10.1371/Journal.Pone.0077582  0.336
2013 Stoddart LA, Briddon SJ, Hill SJ. Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery. Future Medicinal Chemistry. 5: 1367-9. PMID 23919546 DOI: 10.4155/Fmc.13.110  0.468
2013 Vernall AJ, Stoddart LA, Briddon SJ, Ng HW, Laughton CA, Doughty SW, Hill SJ, Kellam B. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry. 11: 5673-82. PMID 23881285 DOI: 10.1039/C3Ob41221K  0.77
2013 Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. Embo Reports. 14: 726-32. PMID 23817552 DOI: 10.1038/Embor.2013.89  0.677
2013 Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. Journal of Medicinal Chemistry. 56: 3852-65. PMID 23614528 DOI: 10.1021/Jm400348G  0.782
2012 Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chemistry & Biology. 19: 1105-15. PMID 22999879 DOI: 10.1016/J.Chembiol.2012.07.014  0.747
2012 Vernall AJ, Stoddart LA, Briddon SJ, Hill SJ, Kellam B. Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. Journal of Medicinal Chemistry. 55: 1771-82. PMID 22277057 DOI: 10.1021/Jm201722Y  0.765
2012 Rose RH, Briddon SJ, Hill SJ. A novel fluorescent histamine H(1) receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands. British Journal of Pharmacology. 165: 1789-800. PMID 21880035 DOI: 10.1111/J.1476-5381.2011.01640.X  0.501
2012 Dale CL, Hill SJ, Kellam B. New potent, short-linker BODIPY-630/650™ labelled fluorescent adenosine receptor agonists Medchemcomm. 3: 333-338. DOI: 10.1039/C2Md00247G  0.758
2011 Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry. 54: 6874-87. PMID 21870877 DOI: 10.1021/Jm2008562  0.828
2011 May LT, Bridge LJ, Stoddart LA, Briddon SJ, Hill SJ. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3465-76. PMID 21715680 DOI: 10.1096/Fj.11-186296  0.483
2011 Briddon SJ, Kellam B, Hill SJ. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods in Molecular Biology (Clifton, N.J.). 746: 211-36. PMID 21607859 DOI: 10.1007/978-1-61779-126-0_11  0.734
2010 May LT, Self TJ, Briddon SJ, Hill SJ. The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells. Molecular Pharmacology. 78: 511-23. PMID 20571079 DOI: 10.1124/Mol.110.064493  0.441
2010 Kilpatrick LE, Briddon SJ, Hill SJ, Holliday ND. Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation. British Journal of Pharmacology. 160: 892-906. PMID 20438572 DOI: 10.1111/J.1476-5381.2010.00676.X  0.437
2010 Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. British Journal of Pharmacology. 159: 772-86. PMID 20105183 DOI: 10.1111/J.1476-5381.2009.00488.X  0.763
2010 May LT, Briddon SJ, Hill SJ. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Molecular Pharmacology. 77: 678-86. PMID 20086038 DOI: 10.1124/Mol.109.063065  0.48
2010 Bridge LJ, King JR, Hill SJ, Owen MR. Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition. Mathematical Biosciences. 223: 115-32. PMID 19932126 DOI: 10.1016/J.Mbs.2009.11.005  0.355
2010 Woodroffe PJ, Bridge LJ, King JR, Chen CY, Hill SJ. Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity. Journal of Mathematical Biology. 60: 313-46. PMID 19347339 DOI: 10.1007/S00285-009-0268-5  0.305
2010 Corriden R, Stoddart L, Briddon S, Hill SJ. Studying the Diffusion Characteristics of Different Activity States of the Human Adenosine-A3 Receptor Using Fluorescence Correlation Spectroscopy Biophysical Journal. 98: 289a-290a. DOI: 10.1016/J.Bpj.2009.12.1578  0.464
2010 Briddon SJ, Hern JA, Hill SJ. Use of Fluorescence Correlation Spectroscopy to Study the Diffusion of G Protein-coupled Receptors G Protein-Coupled Receptors: Essential Methods. 169-195. DOI: 10.1002/9780470749210.ch9  0.356
2010 May LT, Holliday ND, Hill SJ. The Evolving Pharmacology of GPCRs Gpcr Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. 27-60. DOI: 10.1002/9780470627327.ch2  0.313
2009 Rose RH, Briddon SJ, Hill SJ. The Effect of Agonist Activation and Homodimerisation on the Membrane Diffusion of the Human Histamine H1 Receptor Biophysical Journal. 96: 6-8. DOI: 10.1016/J.Bpj.2008.12.3581  0.343
2009 May LT, Briddon SJ, Hill SJ. Live Cell Imaging Of The Kinetics Of Ligand Binding At The Human Adenosine A3 Receptor Biophysical Journal. 96: 677a. DOI: 10.1016/J.Bpj.2008.12.3576  0.463
2009 Briddon S, Hill SJ. An Investigation Into the Membrane Diffusion and Organisation of Adenosine Receptor Homo-oligomers Biophysical Journal. 96: 676a-677a. DOI: 10.1016/J.Bpj.2008.12.3575  0.437
2008 Briddon SJ, Gandía J, Amaral OB, Ferré S, Lluís C, Franco R, Hill SJ, Ciruela F. Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochimica Et Biophysica Acta. 1783: 2262-8. PMID 18691614 DOI: 10.1016/J.Bbamcr.2008.07.006  0.364
2008 Longden J, Cooke EL, Hill SJ. Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells. British Journal of Pharmacology. 153: 1513-27. PMID 18223665 DOI: 10.1038/Sj.Bjp.0707691  0.518
2008 Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 850-60. PMID 17959910 DOI: 10.1096/Fj.07-8180Com  0.71
2007 Briddon SJ, Hill SJ. Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes. Trends in Pharmacological Sciences. 28: 637-45. PMID 18001848 DOI: 10.1016/J.Tips.2007.09.008  0.49
2007 Baker JG, Hill SJ. Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates. Trends in Pharmacological Sciences. 28: 374-81. PMID 17629959 DOI: 10.1016/J.Tips.2007.06.011  0.43
2007 Middleton RJ, Briddon SJ, Cordeaux Y, Yates AS, Dale CL, George MW, Baker JG, Hill SJ, Kellam B. New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells. Journal of Medicinal Chemistry. 50: 782-93. PMID 17249651 DOI: 10.1021/Jm061279I  0.763
2007 Baker JG, Hill SJ. A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor. The Journal of Pharmacology and Experimental Therapeutics. 320: 218-28. PMID 17018691 DOI: 10.1124/Jpet.106.113589  0.428
2006 Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, et al. Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 4287-90. PMID 16753296 DOI: 10.1016/j.bmcl.2006.05.062  0.413
2006 Hill SJ. G-protein-coupled receptors: past, present and future. British Journal of Pharmacology. 147: S27-37. PMID 16402114 DOI: 10.1038/Sj.Bjp.0706455  0.369
2005 Self TJ, Oakley SM, Hill SJ. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells. British Journal of Pharmacology. 146: 612-24. PMID 16086035 DOI: 10.1038/Sj.Bjp.0706337  0.33
2004 Cordeaux Y, Ijzerman AP, Hill SJ. Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. British Journal of Pharmacology. 143: 705-14. PMID 15302686 DOI: 10.1038/Sj.Bjp.0705925  0.351
2004 Briddon SJ, Middleton RJ, Cordeaux Y, Flavin FM, Weinstein JA, George MW, Kellam B, Hill SJ. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 4673-8. PMID 15070776 DOI: 10.1073/Pnas.0400420101  0.708
2004 Briddon SJ, Middleton RJ, Yates AS, George MW, Kellam B, Hill SJ. Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level. Faraday Discussions. 126: 197-207; discussion . PMID 14992407 DOI: 10.1039/B307407B  0.706
2003 Baker JG, Hall IP, Hill SJ. Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses. Molecular Pharmacology. 64: 679-88. PMID 12920204 DOI: 10.1124/Mol.64.3.679  0.389
2003 Chen CY, Cordeaux Y, Hill SJ, King JR. Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy. Bulletin of Mathematical Biology. 65: 933-58. PMID 12909256 DOI: 10.1016/S0092-8240(03)00055-7  0.324
2003 Baker JG, Hall IP, Hill SJ. Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist. British Journal of Pharmacology. 139: 232-42. PMID 12770928 DOI: 10.1038/Sj.Bjp.0705287  0.314
2002 Baker G, Hall I, Hill S. Agonist-specific Temporal Characteristics of β2-Adrenoceptor-Stimulated Gene Transcription Response in CHO-K1 Cells Transfected with the Human β2-Adrenoceptor Clinical Science. 103: 59P-60P. DOI: 10.1042/Cs103059Pb  0.304
2001 Hill SJ, Baker JG, Rees S. Reporter-gene systems for the study of G-protein-coupled receptors. Current Opinion in Pharmacology. 1: 526-32. PMID 11764780 DOI: 10.1016/S1471-4892(01)00091-1  0.303
2000 Cordeaux Y, Briddon SJ, Megson AE, McDonnell J, Dickenson JM, Hill SJ. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. Molecular Pharmacology. 58: 1075-84. PMID 11040056 DOI: 10.1124/Mol.58.5.1075  0.362
1998 Walker EM, Bispham JR, Hill SJ. Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells. Biochemical Pharmacology. 56: 1455-62. PMID 9827577 DOI: 10.1016/S0006-2952(98)00256-1  0.362
1998 Haynes JM, Alexander SP, Hill SJ. A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig. British Journal of Pharmacology. 125: 570-6. PMID 9806342 DOI: 10.1038/Sj.Bjp.0702095  0.375
1998 Dickenson JM, Hill SJ. Involvement of G-protein betagamma subunits in coupling the adenosine A1 receptor to phospholipase C in transfected CHO cells. European Journal of Pharmacology. 355: 85-93. PMID 9754942 DOI: 10.1016/S0014-2999(98)00468-3  0.329
1998 Dickenson JM, Hill SJ. Human 5-HT1B receptor stimulated inositol phospholipid hydrolysis in CHO cells: synergy with Gq-coupled receptors. European Journal of Pharmacology. 348: 279-85. PMID 9652344 DOI: 10.1016/S0014-2999(98)00148-4  0.441
1998 Selbie LA, Hill SJ. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends in Pharmacological Sciences. 19: 87-93. PMID 9584624 DOI: 10.1016/S0165-6147(97)01166-8  0.327
1997 Cooper J, Hill SJ, Alexander SP. An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. British Journal of Pharmacology. 122: 546-50. PMID 9351513 DOI: 10.1038/Sj.Bjp.0701401  0.344
1996 Alexander SP, Cooper J, Shine J, Hill SJ. Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells. British Journal of Pharmacology. 119: 1286-90. PMID 8937736 DOI: 10.1111/J.1476-5381.1996.Tb16035.X  0.31
1996 Clark EA, Hill SJ. Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. European Journal of Pharmacology. 296: 223-5. PMID 8838460 DOI: 10.1016/0014-2999(95)00800-4  0.357
1996 Dickenson JM, Hill SJ. Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells. European Journal of Pharmacology. 302: 141-51. PMID 8791002 DOI: 10.1016/0014-2999(96)00039-8  0.394
1995 Megson AC, Dickenson JM, Townsend-Nicholson A, Hill SJ. Synergy between the inositol phosphate responses to transfected human adenosine A1-receptors and constitutive P2-purinoceptors in CHO-K1 cells. British Journal of Pharmacology. 115: 1415-24. PMID 8564200 DOI: 10.1111/J.1476-5381.1995.Tb16632.X  0.345
1994 Dickenson JM, Hill SJ. Interactions between adenosine A1- and histamine H1-receptors. The International Journal of Biochemistry. 26: 959-69. PMID 8088416 DOI: 10.1016/0020-711X(94)90066-3  0.417
1994 Iredale PA, Alexander SP, Hill SJ. Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. British Journal of Pharmacology. 111: 1252-6. PMID 8032613 DOI: 10.1111/J.1476-5381.1994.Tb14880.X  0.36
1994 Peakman MC, Hill SJ. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. British Journal of Pharmacology. 111: 191-8. PMID 8012696 DOI: 10.1111/J.1476-5381.1994.Tb14043.X  0.392
1994 Alexander SP, Losinski A, Kendall DA, Hill SJ. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aorta. British Journal of Pharmacology. 111: 185-90. PMID 8012695 DOI: 10.1111/J.1476-5381.1994.Tb14042.X  0.323
1994 Peakman MC, Hill SJ. Endogenous expression of histamine H1 receptors functionally coupled to phosphoinositide hydrolysis in C6 glioma cells: regulation by cyclic AMP. British Journal of Pharmacology. 113: 1554-60. PMID 7889313 DOI: 10.1111/J.1476-5381.1994.Tb17173.X  0.313
1994 Alexander SP, Curtis AR, Kendall DA, Hill SJ. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex. British Journal of Pharmacology. 113: 1501-7. PMID 7889308 DOI: 10.1111/J.1476-5381.1994.Tb17166.X  0.331
1993 White TE, Dickenson JM, Hill SJ. Histamine H1-receptor-mediated inositol phospholipid hydrolysis in DDT1MF-2 cells: agonist and antagonist properties. British Journal of Pharmacology. 108: 196-203. PMID 8381320 DOI: 10.1111/J.1476-5381.1993.Tb13462.X  0.313
1993 Iredale PA, Fukui H, Hill SJ. High, stable expression of the bovine histamine H1-receptor coupled to [Ca2+]i mobilisation in CHO-K1 cells. Biochemical and Biophysical Research Communications. 195: 1294-300. PMID 8216261 DOI: 10.1006/bbrc.1993.2184  0.31
1993 Dickenson JM, Hill SJ. Coupling of histamine H1 and adenosine A1 receptors to phospholipase C in DDT1MF-2 cells: synergistic interactions and regulation by cyclic AMP. Biochemical Society Transactions. 21: 1124-9. PMID 8131910 DOI: 10.1042/Bst0211124  0.313
1992 Hill SJ. Multiple histamine receptors: properties and functional characteristics. Biochemical Society Transactions. 20: 122-5. PMID 1321744 DOI: 10.1042/Bst0200122  0.364
1991 Hill SJ. Histamine receptors and interactions between second messenger transduction systems. Agents and Actions. Supplements. 33: 145-59. PMID 1647127  0.318
1990 Ottosson A, Hill SJ, Edvinsson L. Histamine receptors in brain vessels of guinea-pig: in-vitro pharmacology and ligand binding. Acta Physiologica Scandinavica. 140: 135-41. PMID 2177313 DOI: 10.1111/j.1748-1716.1990.tb08984.x  0.364
1989 Alexander SP, Kendall DA, Hill SJ. Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex. British Journal of Pharmacology. 98: 1241-8. PMID 2482102 DOI: 10.1111/J.1476-5381.1989.Tb12670.X  0.359
1987 Hill SJ, Kendall DA. Studies on the adenosine-receptor mediating the augmentation of histamine-induced inositol phospholipid hydrolysis in guinea-pig cerebral cortex. British Journal of Pharmacology. 91: 661-9. PMID 3038249 DOI: 10.1111/J.1476-5381.1987.Tb11260.X  0.334
1987 Hill SJ. Histamine receptors branch out. Nature. 327: 104-5. PMID 3033514 DOI: 10.1038/327104A0  0.372
1987 Hill SJ. Histamine receptors in the mammalian central nervous system: biochemical studies. Progress in Medicinal Chemistry. 24: 29-84. PMID 2849144 DOI: 10.1016/S0079-6468(08)70419-3  0.36
1986 Donaldson J, Hill SJ. Enhancement of histamine H1-receptor agonist activity by 1,4-dithiothreitol in guinea-pig cerebellum and cerebral cortex. Journal of Neurochemistry. 47: 1476-82. PMID 3020176 DOI: 10.1111/J.1471-4159.1986.Tb00781.X  0.3
1985 Al-Gadi M, Hill SJ. Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. British Journal of Pharmacology. 85: 877-88. PMID 2994788 DOI: 10.1111/J.1476-5381.1985.Tb11087.X  0.324
1978 Hill SJ, Young JM, Marrian DH. Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle. Nature. 270: 361-3. PMID 593357 DOI: 10.1038/270361A0  0.364
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