Hai Qian - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yang B, Yin C, Zhou Y, Wang Q, Jiang Y, Bai Y, Qian H, Xing G, Wang S, Li F, Feng Y, Zhang Y, Cai J, Michael A, Lu R. Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ. Toxicology. 152248. PMID 31330227 DOI: 10.1016/j.tox.2019.152248  0.32
2019 Li Z, Liu C, Yang J, Zhou J, Ye Z, Feng D, Yue N, Tong J, Huang W, Qian H. Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold. European Journal of Medicinal Chemistry. 179: 608-622. PMID 31279294 DOI: 10.1016/j.ejmech.2019.06.087  0.32
2019 Li J, Nie C, Qiao Y, Hu J, Li Q, Wang Q, Pu X, Yan L, Qian H. Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists. European Journal of Medicinal Chemistry. 178: 433-445. PMID 31202991 DOI: 10.1016/j.ejmech.2019.06.007  0.32
2019 Kairuki M, Qiu Q, Pan M, Li Q, Zhou J, Ghaleb H, Huang W, Qian H, Jiang C. Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells. Bioorganic & Medicinal Chemistry. PMID 31202598 DOI: 10.1016/j.bmc.2019.06.013  0.32
2019 Bi X, Li J, Li J, Shi W, Dai Y, Li Q, Zhang W, Huang W, Qian H, Jiang C. Design, synthesis and biological evaluation of novel 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as potential BRD4 inhibitors. Bioorganic & Medicinal Chemistry. PMID 31079968 DOI: 10.1016/j.bmc.2019.05.006  0.32
2019 Dai Y, Yue N, Liu C, Cai X, Su X, Bi X, Li Q, Li C, Huang W, Qian H. Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates. Bioorganic Chemistry. 88: 102945. PMID 31054430 DOI: 10.1016/j.bioorg.2019.102945  0.4
2019 Shao B, Qian H, Li Q, Aprahamian I. Structure Property Analysis of the Solution and Solid-State Properties of Bistable Photochromic Hydrazones. Journal of the American Chemical Society. PMID 31050408 DOI: 10.1021/jacs.9b03932  0.44
2019 Dai Y, Cai X, Bi X, Liu C, Yue N, Zhu Y, Zhou J, Fu M, Huang W, Qian H. Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance. European Journal of Medicinal Chemistry. 171: 104-115. PMID 30913525 DOI: 10.1016/j.ejmech.2019.03.031  0.32
2019 Qiu Q, Zhou J, Shi W, Kairuki M, Huang W, Qian H. Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance. Bioorganic Chemistry. 86: 166-175. PMID 30710850 DOI: 10.1016/j.bioorg.2019.01.039  0.32
2018 Li J, Liu Y, Li H, Shi W, Bi X, Qiu Q, Zhang B, Huang W, Qian H. pH-Sensitive micelles with mitochondria-targeted and aggregation-induced emission characterization: synthesis, cytotoxicity and biological applications. Biomaterials Science. PMID 30259038 DOI: 10.1039/c8bm00889b  0.32
2018 Shao B, Baroncini M, Qian H, Bussotti L, Di Donato M, Credi A, Aprahamian I. Solution and Solid-State Emission Toggling of a Photochromic Hydrazone. Journal of the American Chemical Society. PMID 30251843 DOI: 10.1021/jacs.8b07108  0.44
2018 Li Q, Qian H, Shao B, Hughes RP, Aprahamian I. Building Strain with Large Macrocycles and using it to Tune the Thermal Half-Lives of Hydrazone Photochromes. Journal of the American Chemical Society. PMID 30133273 DOI: 10.1021/jacs.8b07612  0.44
2018 Liu Y, Liao C, Zhou J, Liu C, Li Q, Jiang Y, Qian H. Novel benzodiazepines derivatives as analgesic modulating for Transient receptor potential vanilloid 1. Bioorganic & Medicinal Chemistry. PMID 30093345 DOI: 10.1016/j.bmc.2018.08.002  0.32
2018 Li Z, Chen Y, Zhang Y, Jiang H, Liu Y, Chen Y, Zhang L, Qian H. Structure-based design of free fatty acid receptor 1 agonists bearing non-biphenyl scaffold. Bioorganic Chemistry. 80: 296-302. PMID 29980115 DOI: 10.1016/j.bioorg.2018.06.039  0.32
2018 Ghaleb H, Li H, Kairuki M, Qiu Q, Bi X, Liu C, Liao C, Li J, Hezam K, Huang W, Qian H. Design, Synthesis and Evaluation of a Novel Series of Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. Chemical Biology & Drug Design. PMID 29786944 DOI: 10.1111/cbdd.13338  0.32
2018 Liu C, Li Z, Shi W, Li H, Wang N, Dai Y, Liao C, Huang W, Qian H. Improving metabolic stability with deuterium: The discovery of HWL-066, a potent and long-acting free fatty acid receptor 1 agonists. Chemical Biology & Drug Design. PMID 29777569 DOI: 10.1111/cbdd.13321  0.32
2018 Wang Y, Shen T, Fang P, Zhou J, Lou K, Cen Z, Qian H, Zhou J, Liu N, Lian J. The role and mechanism of chaperones Calnexin/Calreticulin in which ALLN selectively rescues the trafficking defective of HERG-A561V mutation. Bioscience Reports. PMID 29752336 DOI: 10.1042/BSR20171269  0.32
2018 Cai X, Sun L, Dai Y, Avraham Y, Liu C, Han J, Liu Y, Feng D, Huang W, Qian H. Novel fatty acid chain modified GLP-1 derivatives with prolonged in vivo glucose-lowering ability and balanced glucoregulatory activity. Bioorganic & Medicinal Chemistry. PMID 29673717 DOI: 10.1016/j.bmc.2018.04.022  0.32
2018 Gao Y, Shi W, Cui J, Liu C, Bi X, Li Z, Huang W, Wang G, Qian H. Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors. Bioorganic & Medicinal Chemistry. PMID 29631786 DOI: 10.1016/j.bmc.2018.03.045  0.32
2018 Wu Y, Liu Y, Cai Z, Qin H, Li H, Su W, Wang Y, Qian H, Jiang L, Wu M, Pang J, Chen Y. Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation? Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 24: 736-742. PMID 29401205  0.32
2018 Liu Y, Shi X, K C KIS, Sun Y, Liu F, Qian H, Zhang J. Microsurgical Treatment for Complex Basilar Artery Aneurysms With Long-Term Follow-Up in A Series of 35 Cases. World Neurosurgery. PMID 29317359 DOI: 10.1016/j.wneu.2017.12.158  0.32
2017 Liao C, Liu Y, Liu C, Zhou J, Li H, Wang N, Li J, Liu T, Ghaleb H, Huang W, Qian H. Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide. Bioorganic & Medicinal Chemistry. PMID 29317149 DOI: 10.1016/j.bmc.2017.12.048  0.32
2017 Li Z, Liu C, Shi W, Cai X, Dai Y, Liao C, Huang W, Qian H. Identification of highly potent and orally available free fatty acid receptor 1 agonists bearing isoxazole scaffold. Bioorganic & Medicinal Chemistry. PMID 29291938 DOI: 10.1016/j.bmc.2017.12.030  0.32
2017 Li Z, Liu C, Xu X, Shi W, Li H, Dai Y, Cai X, Huang W, Qian H. Design, synthesis, and biological evaluation of deuterated phenylpropionic acid derivatives as potent and long-acting free fatty acid receptor 1 agonists. Bioorganic Chemistry. 76: 303-313. PMID 29223807 DOI: 10.1016/j.bioorg.2017.12.012  0.32
2017 Li J, Gu W, Bi X, Li H, Liao C, Liu C, Huang W, Qian H. Design, synthesis, and biological evaluation of thieno[2,3-d]pyrimidine derivatives as novel dual c-Met and VEGFR-2 kinase inhibitors. Bioorganic & Medicinal Chemistry. PMID 29146452 DOI: 10.1016/j.bmc.2017.11.010  0.32
2017 Zhou J, Cai X, Huang X, Dai Y, Sun L, Zhang B, Yang B, Lin H, Huang W, Qian H. A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects. European Journal of Medicinal Chemistry. 138: 1158-1169. PMID 28772236 DOI: 10.1016/j.ejmech.2017.07.046  0.32
2017 Li Z, Liu C, Xu X, Qiu Q, Su X, Dai Y, Yang J, Li H, Shi W, Liao C, Pan M, Huang W, Qian H. Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. European Journal of Medicinal Chemistry. 138: 458-479. PMID 28689096 DOI: 10.1016/j.ejmech.2017.07.001  0.4
2017 Dai Y, Cai X, Shi W, Bi X, Su X, Pan M, Li H, Lin H, Huang W, Qian H. Pro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. PMID 28664269 DOI: 10.1007/s00726-017-2453-y  0.4
2017 Pan M, Cui J, Jiao L, Ghaleb H, Liao C, Zhou J, Kairuki M, Lin H, Huang W, Qian H. Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors. Bioorganic & Medicinal Chemistry. PMID 28645831 DOI: 10.1016/j.bmc.2017.06.015  0.32
2017 Qian H, Pramanik S, Aprahamian I. Photochromic Hydrazone Switches with Extremely Long Thermal Half-Lives. Journal of the American Chemical Society. PMID 28644015 DOI: 10.1021/jacs.7b04993  0.44
2017 Zhang B, Shi W, Li J, Liao C, Yang L, Huang W, Qian H. Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities. Chemical Biology & Drug Design. PMID 28524273 DOI: 10.1111/cbdd.13023  0.32
2017 Zhang B, Shi W, Li J, Liao C, Li M, Huang W, Qian H. Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities. Amino Acids. PMID 28474125 DOI: 10.1007/s00726-017-2434-1  0.32
2017 Gu W, Dai Y, Qiang H, Shi W, Liao C, Zhao F, Huang W, Qian H. Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors. Bioorganic Chemistry. 72: 116-122. PMID 28411406 DOI: 10.1016/j.bioorg.2017.04.001  0.32
2017 Qiu Q, Liu B, Cui J, Li Z, Deng X, Qiang H, Li J, Liao C, Zhang B, Shi W, Pan M, Huang W, Qian H. Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl) quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-glycoprotein-Mediated Multidrug Resistance. Journal of Medicinal Chemistry. PMID 28355069 DOI: 10.1021/acs.jmedchem.6b01787  0.32
2017 Yang J, Li Z, Li H, Liu C, Wang N, Shi W, Liao C, Cai X, Huang W, Qian H. Design, synthesis and structure-activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker. Bioorganic & Medicinal Chemistry. PMID 28285923 DOI: 10.1016/j.bmc.2017.03.001  0.32
2017 Liu Y, Shi X, Liu F, Sun Y, Qian H, Lei T. Bilateral cavernous carotid aneurysms treated by two-stage extracranial-intracranial bypass followed by parent artery occlusion: case report and literature review. Acta Neurochirurgica. PMID 28181086 DOI: 10.1007/s00701-017-3101-8  0.32
2017 Qian H, Wang YY, Guo DS, Aprahamian I. Controlling the Isomerization Rate of an Azo-BF2 Switch using Aggregation. Journal of the American Chemical Society. PMID 28072532 DOI: 10.1021/jacs.6b10982  0.44
2017 Qian H, Cousins ME, Horak EH, Wakefield A, Liptak MD, Aprahamian I. Suppression of Kasha's rule as a mechanism for fluorescent molecular rotors and aggregation-induced emission. Nature Chemistry. 9: 83-87. PMID 27995926 DOI: 10.1038/nchem.2612  0.44
2015 Qian H, Aprahamian I. An emissive and pH switchable hydrazone-based hydrogel. Chemical Communications (Cambridge, England). 51: 11158-61. PMID 25989245 DOI: 10.1039/c5cc03007b  0.4
2013 Robbins TF, Qian H, Su X, Hughes RP, Aprahamian I. Cyanide detection using a triazolopyridinium salt. Organic Letters. 15: 2386-9. PMID 23627279 DOI: 10.1021/ol4008298  0.4
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