| Year |
Citation |
Score |
| 2023 |
Yayon N, Kedlian VR, Boehme L, Suo C, Wachter B, Beuschel RT, Amsalem O, Polanski K, Koplev S, Tuck E, Dann E, Van Hulle J, Perera S, Putteman T, Predeus AV, ... ... Germain RN, et al. A spatial human thymus cell atlas mapped to a continuous tissue axis. Biorxiv : the Preprint Server For Biology. PMID 37986877 DOI: 10.1101/2023.10.25.562925 |
0.302 |
|
| 2023 |
Chan W, Cao YM, Zhao X, Schrom EC, Jia D, Song J, Sibener LV, Dong S, Fernandes RA, Bradfield CJ, Smelkinson M, Kabat J, Hor JL, Altan-Bonnet G, Garcia KC, ... Germain RN, et al. TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. The Journal of Experimental Medicine. 220. PMID 37796477 DOI: 10.1084/jem.20231242 |
0.598 |
|
| 2023 |
Globig AM, Zhao S, Roginsky J, Maltez VI, Guiza J, Avina-Ochoa N, Heeg M, Araujo Hoffmann F, Chaudhary O, Wang J, Senturk G, Chen D, O'Connor C, Pfaff S, Germain RN, et al. The β-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. PMID 37731001 DOI: 10.1038/s41586-023-06568-6 |
0.381 |
|
| 2022 |
Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC. Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.). 376: eabl5282. PMID 35389803 DOI: 10.1126/science.abl5282 |
0.31 |
|
| 2021 |
Wong HS, Germain RN. Mesoscale T cell antigen discrimination emerges from intercellular feedback. Trends in Immunology. PMID 34493455 DOI: 10.1016/j.it.2021.08.006 |
0.398 |
|
| 2021 |
Wong HS, Park K, Gola A, Baptista AP, Miller CH, Deep D, Lou M, Boyd LF, Rudensky AY, Savage PA, Altan-Bonnet G, Tsang JS, Germain RN. A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell. PMID 34157301 DOI: 10.1016/j.cell.2021.05.028 |
0.69 |
|
| 2021 |
Russler-Germain EV, Yi J, Young S, Nutsch K, Wong HS, Ai TL, Chai JN, Durai V, Kaplan DH, Germain RN, Murphy KM, Hsieh CS. Gut presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation. Elife. 10. PMID 33533717 DOI: 10.7554/eLife.54792 |
0.371 |
|
| 2020 |
Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, ... ... Germain RN, et al. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. PMID 32362324 DOI: 10.1016/J.Immuni.2020.04.001 |
0.387 |
|
| 2020 |
Grant SM, Lou M, Yao L, Germain RN, Radtke AJ. The lymph node at a glance - how spatial organization optimizes the immune response. Journal of Cell Science. 133. PMID 32144196 DOI: 10.1242/Jcs.241828 |
0.434 |
|
| 2019 |
Germain RN. The Cellular Determinants of Adaptive Immunity. The New England Journal of Medicine. 381: 1083-1085. PMID 31502768 DOI: 10.1056/Nejmcibr1909387 |
0.3 |
|
| 2019 |
Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP. Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells. The Journal of Experimental Medicine. PMID 31405895 DOI: 10.1084/Jem.20181218 |
0.391 |
|
| 2019 |
Gottschalk RA, Dorrington MG, Dutta B, Krauss KS, Martins AJ, Uderhardt S, Chan W, Tsang JS, Torabi-Parizi P, Fraser ID, Germain RN. IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses. Elife. 8. PMID 31385572 DOI: 10.7554/Elife.46836 |
0.32 |
|
| 2019 |
Baptista AP, Gola A, Huang Y, Milanez-Almeida P, Torabi-Parizi P, Urban JF, Shapiro VS, Gerner MY, Germain RN. The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4 T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity. PMID 31053504 DOI: 10.1016/J.Immuni.2019.04.001 |
0.513 |
|
| 2019 |
Li W, Germain RN, Gerner MY. High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging. Nature Protocols. PMID 31028373 DOI: 10.1038/S41596-019-0156-4 |
0.305 |
|
| 2019 |
Uderhardt S, Martins AJ, Tsang JS, Lämmermann T, Germain RN. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. PMID 30955887 DOI: 10.1016/J.Cell.2019.02.028 |
0.31 |
|
| 2019 |
Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, ... Germain RN, et al. Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors. Science Immunology. 4. PMID 30824528 DOI: 10.1126/Sciimmunol.Aaw1941 |
0.321 |
|
| 2019 |
Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Quantifying in situ adaptive immune cell cognate interactions in humans. Nature Immunology. PMID 30778242 DOI: 10.1038/S41590-019-0315-3 |
0.503 |
|
| 2019 |
Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. PMID 30712876 DOI: 10.1016/J.Cell.2018.12.040 |
0.331 |
|
| 2019 |
Franco LM, Gadkari M, Howe KN, Sun J, Kardava L, Kumar P, Kumari S, Hu Z, Fraser IDC, Moir S, Tsang JS, Germain RN. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. The Journal of Experimental Medicine. PMID 30674564 DOI: 10.1084/Jem.20180595 |
0.396 |
|
| 2018 |
Germain RN, Huang Y. ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move? Current Opinion in Immunology. 56: 76-81. PMID 30472437 DOI: 10.1016/J.Coi.2018.11.001 |
0.478 |
|
| 2018 |
Huang Y, Mao K, Germain RN. Thinking differently about ILCs-Not just tissue resident and not just the same as CD4 T-cell effectors. Immunological Reviews. 286: 160-171. PMID 30294968 DOI: 10.1111/Imr.12704 |
0.495 |
|
| 2018 |
Gola A, Silman D, Walters AA, Sridhar S, Uderhardt S, Salman AM, Halbroth BR, Bellamy D, Bowyer G, Powlson J, Baker M, Venkatraman N, Poulton I, Berrie E, Roberts R, ... ... Germain RN, et al. Prime and target immunization protects against liver-stage malaria in mice. Science Translational Medicine. 10. PMID 30257955 DOI: 10.1126/Scitranslmed.Aap9128 |
0.339 |
|
| 2018 |
Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, ... ... Germain RN, et al. Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity. Nature Immunology. PMID 30127432 DOI: 10.1038/S41590-018-0182-3 |
0.443 |
|
| 2018 |
Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH. Spatial distribution and function of T follicular regulatory cells in human lymph nodes. The Journal of Experimental Medicine. PMID 29769249 DOI: 10.1084/Jem.20171940 |
0.479 |
|
| 2018 |
Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN. Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism. Nature. PMID 29364878 DOI: 10.1038/Nature25437 |
0.441 |
|
| 2018 |
Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF, Paul WE, Germain RN. S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. Science (New York, N.Y.). 359: 114-119. PMID 29302015 DOI: 10.1126/Science.Aam5809 |
0.379 |
|
| 2017 |
Wong HS, Germain RN. Robust control of the adaptive immune system. Seminars in Immunology. PMID 29290544 DOI: 10.1016/J.Smim.2017.12.009 |
0.437 |
|
| 2017 |
Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M. Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations. Immunity. 47: 862-874.e3. PMID 29166587 DOI: 10.1016/J.Immuni.2017.10.020 |
0.409 |
|
| 2017 |
Gerner MY, Casey KA, Kastenmuller W, Germain RN. Dendritic cell and antigen dispersal landscapes regulate T cell immunity. The Journal of Experimental Medicine. PMID 28847868 DOI: 10.1084/Jem.20170335 |
0.485 |
|
| 2017 |
Li W, Germain RN, Gerner MY. Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D). Proceedings of the National Academy of Sciences of the United States of America. PMID 28808033 DOI: 10.1073/Pnas.1708981114 |
0.332 |
|
| 2017 |
Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE. Memory-phenotype CD4(+) T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function. Science Immunology. 2. PMID 28783663 DOI: 10.1126/Sciimmunol.Aam9304 |
0.489 |
|
| 2017 |
Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ. Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells. The Journal of Experimental Medicine. PMID 28768709 DOI: 10.1084/Jem.20161955 |
0.457 |
|
| 2017 |
Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. PMID 28389069 DOI: 10.1016/J.Immuni.2017.03.011 |
0.74 |
|
| 2017 |
Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, et al. CD8 T Cells Orchestrate pDC-XCR1 Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity. 46: 205-219. PMID 28190711 DOI: 10.1016/J.Immuni.2017.01.003 |
0.473 |
|
| 2017 |
Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. The Journal of Experimental Medicine. PMID 28130403 DOI: 10.1084/Jem.20161318 |
0.513 |
|
| 2017 |
Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, ... ... Germain RN, et al. Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies. Science Translational Medicine. 9. PMID 28100833 DOI: 10.1126/Scitranslmed.Aag2285 |
0.392 |
|
| 2017 |
Radtke AJ, Anderson CF, Riteau N, Rausch K, Scaria P, Kelnhofer ER, Howard RF, Sher A, Germain RN, Duffy P. Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate. Scientific Reports. 7: 40312. PMID 28091576 DOI: 10.1038/Srep40312 |
0.353 |
|
| 2016 |
Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 27903737 DOI: 10.4049/Jimmunol.1601448 |
0.456 |
|
| 2016 |
Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, et al. Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy. Nature. PMID 27501248 DOI: 10.1038/Nature19330 |
0.433 |
|
| 2016 |
Gottschalk RA, Martins AJ, Angermann BR, Dutta B, Ng CE, Uderhardt S, Tsang JS, Fraser ID, Meier-Schellersheim M, Germain RN. Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses. Cell Systems. PMID 27237739 DOI: 10.1016/J.Cels.2016.04.016 |
0.313 |
|
| 2016 |
Liarski V, Sibley A, Panhuys Nv, Germain R, Giger M, Clark M. II-07 Generation of cell distance mapping plus (CDM+): mapping cognate T cell: dendritic cell interactions and their relationship to cell shape Lupus Science & Medicine. 3. DOI: 10.1136/Lupus-2016-000179.37 |
0.492 |
|
| 2015 |
Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. PMID 26605524 DOI: 10.1038/Nature16169 |
0.518 |
|
| 2015 |
Germain RN. Tracking the T cell repertoire. Nature Reviews. Immunology. 15: 730. PMID 26515079 DOI: 10.1038/Nri3922 |
0.43 |
|
| 2015 |
Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y. Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity. Cell. 163: 354-66. PMID 26451485 DOI: 10.1016/J.Cell.2015.08.030 |
0.323 |
|
| 2015 |
Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR. NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis. The Journal of Experimental Medicine. PMID 26347474 DOI: 10.1084/Jem.20141678 |
0.338 |
|
| 2015 |
Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W. Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions. Cell. 162: 1322-37. PMID 26296422 DOI: 10.1016/J.Cell.2015.08.004 |
0.503 |
|
| 2015 |
Manes NP, Angermann BR, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A. Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. Molecular & Cellular Proteomics : McP. 14: 2661-81. PMID 26199343 DOI: 10.1074/Mcp.M115.048918 |
0.301 |
|
| 2015 |
Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metabolism. 21: 543-57. PMID 25863247 DOI: 10.1016/J.Cmet.2015.03.005 |
0.466 |
|
| 2015 |
Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP, Cockburn IA. Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. Plos Pathogens. 11: e1004637. PMID 25658939 DOI: 10.1371/Journal.Ppat.1004637 |
0.438 |
|
| 2015 |
Subramanian N, Torabi-Parizi P, Gottschalk RA, Germain RN, Dutta B. Network representations of immune system complexity. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 7: 13-38. PMID 25625853 DOI: 10.1002/Wsbm.1288 |
0.327 |
|
| 2015 |
Gerner MY, Torabi-Parizi P, Germain RN. Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens. Immunity. 42: 172-85. PMID 25607462 DOI: 10.1016/J.Immuni.2014.12.024 |
0.468 |
|
| 2015 |
Liarski VM, Yanez D, Panhuys Nv, Germain R, Lan L, Giger M, Clark M. THU0374 Use and Validation of Cell Distance Mapping (CDM) in Studying the Pathogenesis of Tubulointerstitial Inflammation in Human Lupus Nephritis Annals of the Rheumatic Diseases. 74: 331-332. DOI: 10.1136/Annrheumdis-2015-Eular.5122 |
0.48 |
|
| 2014 |
Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, ... Germain RN, et al. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. The Journal of Experimental Medicine. 211: 2549-66. PMID 25422492 DOI: 10.1084/Jem.20141307 |
0.401 |
|
| 2014 |
Clatworthy MR, Aronin CE, Mathews RJ, Morgan NY, Smith KG, Germain RN. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nature Medicine. 20: 1458-63. PMID 25384086 DOI: 10.1038/Nm.3709 |
0.375 |
|
| 2014 |
Hodes RJ, Germain RN, Bluestone JA. The regulation of the immune system. Immunology Today. 5: 279-85. PMID 25290540 DOI: 10.1016/0167-5699(84)90145-2 |
0.328 |
|
| 2014 |
Qi H, Kastenmüller W, Germain RN. Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology. 30: 141-67. PMID 25150013 DOI: 10.1146/Annurev-Cellbio-100913-013254 |
0.455 |
|
| 2014 |
Vrisekoop N, Monteiro JP, Mandl JN, Germain RN. Revisiting thymic positive selection and the mature T cell repertoire for antigen. Immunity. 41: 181-90. PMID 25148022 DOI: 10.1016/J.Immuni.2014.07.007 |
0.493 |
|
| 2014 |
van Panhuys N, Klauschen F, Germain RN. T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. Immunity. 41: 63-74. PMID 24981853 DOI: 10.1016/j.immuni.2014.06.003 |
0.41 |
|
| 2014 |
Mandl JN, Germain RN. Focusing in on T cell cross-reactivity. Cell. 157: 1006-8. PMID 24855938 DOI: 10.1016/J.Cell.2014.05.002 |
0.475 |
|
| 2014 |
Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F, et al. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell. 157: 499-513. PMID 24725414 DOI: 10.1016/J.Cell.2014.03.031 |
0.366 |
|
| 2014 |
Mandl JN, Torabi-Parizi P, Germain RN. Visualization and dynamic analysis of host-pathogen interactions. Current Opinion in Immunology. 29: 8-15. PMID 24705104 DOI: 10.1016/J.Coi.2014.03.002 |
0.448 |
|
| 2014 |
Lämmermann T, Germain RN. The multiple faces of leukocyte interstitial migration. Seminars in Immunopathology. 36: 227-51. PMID 24573488 DOI: 10.1007/S00281-014-0418-8 |
0.372 |
|
| 2014 |
Germain RN. Open questions: a rose is a rose is a rose--or not? Bmc Biology. 12: 2. PMID 24484903 DOI: 10.1186/1741-7007-12-2 |
0.466 |
|
| 2014 |
Honda T, Egen JG, Lämmermann T, Kastenmüller W, Torabi-Parizi P, Germain RN. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity. 40: 235-247. PMID 24440150 DOI: 10.1016/J.Immuni.2013.11.017 |
0.499 |
|
| 2014 |
Torabi-Parizi P, Vrisekoop N, Kastenmuller W, Gerner MY, Egen JG, Germain RN. Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung. Journal of Immunology (Baltimore, Md. : 1950). 192: 1651-60. PMID 24431231 DOI: 10.4049/Jimmunol.1301743 |
0.444 |
|
| 2014 |
Petrovas C, Ferrando-Martinez S, Pegu A, Boswell K, Asokan M, Ambrozak D, Kotlyar D, Gerson M, Germain R, Reyes-Teran G, del Rio P, Docobo F, Leal M, Ruiz-Mateos E, Koup RA. B-108 Germinal center CD8 T cells can be redirected to eliminate HIV-expressing T follicular helper cells Jaids Journal of Acquired Immune Deficiency Syndromes. 67: 47. DOI: 10.1097/01.Qai.0000456074.83556.A7 |
0.423 |
|
| 2013 |
Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature. 498: 371-5. PMID 23708969 DOI: 10.1038/Nature12175 |
0.338 |
|
| 2013 |
Tang J, van Panhuys N, Kastenmüller W, Germain RN. The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful. European Journal of Immunology. 43: 1407-12. PMID 23568494 DOI: 10.1002/Eji.201243119 |
0.397 |
|
| 2013 |
Kastenmüller W, Brandes M, Wang Z, Herz J, Egen JG, Germain RN. Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity. 38: 502-13. PMID 23352234 DOI: 10.1016/J.Immuni.2012.11.012 |
0.396 |
|
| 2013 |
Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada GH, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. Dynamic visualization of RANKL and Th17-mediated osteoclast function. The Journal of Clinical Investigation. 123: 866-73. PMID 23321670 DOI: 10.1172/Jci65054 |
0.355 |
|
| 2013 |
Mandl JN, Monteiro JP, Vrisekoop N, Germain RN. T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity. 38: 263-74. PMID 23290521 DOI: 10.1016/J.Immuni.2012.09.011 |
0.501 |
|
| 2013 |
Gottschalk RA, Martins AJ, Sjoelund VH, Angermann BR, Lin B, Germain RN. Recent progress using systems biology approaches to better understand molecular mechanisms of immunity. Seminars in Immunology. 25: 201-8. PMID 23238271 DOI: 10.1016/J.Smim.2012.11.002 |
0.329 |
|
| 2013 |
Honda T, Egen J, Germain R. Regulation of TCR-induced stop signal and T cell-effector function in peripheral tissue through PD-L1-PD-1 signaling Journal of Dermatological Science. 69: e68. DOI: 10.1016/J.Jdermsci.2012.11.510 |
0.309 |
|
| 2012 |
Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY, Germain RN. Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 18036-41. PMID 23071319 DOI: 10.1073/Pnas.1211717109 |
0.452 |
|
| 2012 |
Germain RN. Maintaining system homeostasis: the third law of Newtonian immunology. Nature Immunology. 13: 902-6. PMID 22990887 DOI: 10.1038/Ni.2404 |
0.325 |
|
| 2012 |
Kastenmüller W, Torabi-Parizi P, Subramanian N, Lämmermann T, Germain RN. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell. 150: 1235-48. PMID 22980983 DOI: 10.1016/J.Cell.2012.07.021 |
0.411 |
|
| 2012 |
Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, ... ... Germain RN, et al. CD4 T follicular helper cell dynamics during SIV infection. The Journal of Clinical Investigation. 122: 3281-94. PMID 22922258 DOI: 10.1172/Jci63039 |
0.468 |
|
| 2012 |
Gerner MY, Kastenmuller W, Ifrim I, Kabat J, Germain RN. Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity. 37: 364-76. PMID 22863836 DOI: 10.1016/J.Immuni.2012.07.011 |
0.355 |
|
| 2012 |
Lee M, Mandl JN, Germain RN, Yates AJ. The race for the prize: T-cell trafficking strategies for optimal surveillance. Blood. 120: 1432-8. PMID 22773385 DOI: 10.1182/Blood-2012-04-424655 |
0.421 |
|
| 2012 |
Germain RN, Robey EA, Cahalan MD. A decade of imaging cellular motility and interaction dynamics in the immune system. Science (New York, N.Y.). 336: 1676-81. PMID 22745423 DOI: 10.1126/Science.1221063 |
0.448 |
|
| 2012 |
Gaiser MR, Lämmermann T, Feng X, Igyarto BZ, Kaplan DH, Tessarollo L, Germain RN, Udey MC. Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: E889-97. PMID 22411813 DOI: 10.1073/Pnas.1117674109 |
0.413 |
|
| 2011 |
Germain RN, Burakoff SJ. A remembrance of Baruj Benacerraf (AAI '57) 1920-2011. Journal of Immunology (Baltimore, Md. : 1950). 187: 5465-9. PMID 22102728 DOI: 10.4049/Jimmunol.1190069 |
0.46 |
|
| 2011 |
Mionnet C, Sanos SL, Mondor I, Jorquera A, Laugier JP, Germain RN, Bajénoff M. High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes. Blood. 118: 6115-22. PMID 21937697 DOI: 10.1182/Blood-2011-07-367409 |
0.311 |
|
| 2011 |
Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. Journal of Immunology (Baltimore, Md. : 1950). 187: 3186-97. PMID 21849683 DOI: 10.4049/Jimmunol.1101649 |
0.482 |
|
| 2011 |
Germain RN. Uncovering the role of invariant chain in controlling MHC class II antigen capture. Journal of Immunology (Baltimore, Md. : 1950). 187: 1073-5. PMID 21772033 DOI: 10.4049/Jimmunol.1101663 |
0.337 |
|
| 2011 |
Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity. 34: 807-19. PMID 21596592 DOI: 10.1016/J.Immuni.2011.03.022 |
0.52 |
|
| 2011 |
Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ, Kaplan DH, Kastenmüller W, Germain RN, Seder RA. Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. The Journal of Clinical Investigation. 121: 1782-96. PMID 21540549 DOI: 10.1172/Jci45416 |
0.429 |
|
| 2010 |
Germain RN. Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future. Febs Letters. 584: 4814-22. PMID 20965176 DOI: 10.1016/J.Febslet.2010.10.027 |
0.414 |
|
| 2010 |
Kastenmüller W, Gerner MY, Germain RN. The in situ dynamics of dendritic cell interactions. European Journal of Immunology. 40: 2103-6. PMID 20853494 DOI: 10.1002/Eji.201040482 |
0.435 |
|
| 2010 |
Coward J, Germain RN, Altan-Bonnet G. Perspectives for computer modeling in the study of T cell activation. Cold Spring Harbor Perspectives in Biology. 2: a005538. PMID 20516137 DOI: 10.1101/Cshperspect.A005538 |
0.715 |
|
| 2010 |
Cannons JL, Qi H, Lu KT, Dutta M, Gomez-Rodriguez J, Cheng J, Wakeland EK, Germain RN, Schwartzberg PL. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity. 32: 253-65. PMID 20153220 DOI: 10.1016/J.Immuni.2010.01.010 |
0.499 |
|
| 2010 |
Klauschen F, Meier-Schellersheim M, Mandl J, Qi H, Ishii M, Dietel M, Germain RN, Denkert C. Abstract 98: Automated cell tracking and interaction analysis in intra-vital two-photon microscopy image data Cancer Research. 70: 98-98. DOI: 10.1158/1538-7445.Am10-98 |
0.403 |
|
| 2009 |
Vrisekoop N, Mandl JN, Germain RN. Life and death as a T lymphocyte: from immune protection to HIV pathogenesis. Journal of Biology. 8: 91. PMID 19951397 DOI: 10.1186/Jbiol198 |
0.421 |
|
| 2009 |
Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, ... ... Germain RN, et al. Visualization and identification of IL-7 producing cells in reporter mice. Plos One. 4: e7637. PMID 19907640 DOI: 10.1371/Journal.Pone.0007637 |
0.31 |
|
| 2009 |
Bajénoff M, Germain RN. B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood. 114: 4989-97. PMID 19713459 DOI: 10.1182/Blood-2009-06-229567 |
0.439 |
|
| 2009 |
Klauschen F, Ishii M, Qi H, Bajénoff M, Egen JG, Germain RN, Meier-Schellersheim M. Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nature Protocols. 4: 1305-11. PMID 19696749 DOI: 10.1038/Nprot.2009.129 |
0.308 |
|
| 2009 |
Mueller SN, Germain RN. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Reviews. Immunology. 9: 618-29. PMID 19644499 DOI: 10.1038/Nri2588 |
0.413 |
|
| 2009 |
Klauschen F, Qi H, Egen JG, Germain RN, Meier-Schellersheim M. Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nature Protocols. 4: 1006-12. PMID 19536268 DOI: 10.1038/Nprot.2009.94 |
0.303 |
|
| 2009 |
Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nature Medicine. 15: 410-6. PMID 19330007 DOI: 10.1038/Nm.1946 |
0.403 |
|
| 2009 |
Fraser ID, Germain RN. Navigating the network: signaling cross-talk in hematopoietic cells. Nature Immunology. 10: 327-31. PMID 19295628 DOI: 10.1038/Ni.1711 |
0.309 |
|
| 2008 |
Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature. 455: 764-9. PMID 18843362 DOI: 10.1038/Nature07345 |
0.505 |
|
| 2008 |
Bajénoff M, Glaichenhaus N, Germain RN. Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone. Journal of Immunology (Baltimore, Md. : 1950). 181: 3947-54. PMID 18768849 DOI: 10.4049/Jimmunol.181.6.3947 |
0.439 |
|
| 2008 |
Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science (New York, N.Y.). 321: 1081-4. PMID 18719282 DOI: 10.1126/Science.1158013 |
0.805 |
|
| 2008 |
O'Shea JJ, Hunter CA, Germain RN. T cell heterogeneity: Firmly fixed, predominantly plastic or merely malleable? Nature Immunology. 9: 450-453. PMID 18425095 DOI: 10.1038/Ni0508-450 |
0.423 |
|
| 2008 |
Germain RN, Bajénoff M, Castellino F, Chieppa M, Egen JG, Huang AY, Ishii M, Koo LY, Qi H. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews. 221: 163-81. PMID 18275481 DOI: 10.1111/J.1600-065X.2008.00591.X |
0.382 |
|
| 2008 |
Egen JG, Rothfuchs AG, Feng CG, Winter N, Sher A, Germain RN. Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity. 28: 271-84. PMID 18261937 DOI: 10.1016/J.Immuni.2007.12.010 |
0.447 |
|
| 2008 |
Germain RN. Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm. Immunology. 123: 20-7. PMID 18154615 DOI: 10.1111/J.1365-2567.2007.02779.X |
0.491 |
|
| 2008 |
Bajénoff M, Germain RN. Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function. European Journal of Immunology. S18-33. PMID 17972341 DOI: 10.1002/Eji.200737663 |
0.405 |
|
| 2008 |
Feinerman O, Germain RN, Altan-Bonnet G. Quantitative challenges in understanding ligand discrimination by alphabeta T cells. Molecular Immunology. 45: 619-31. PMID 17825415 DOI: 10.1016/J.Molimm.2007.03.028 |
0.789 |
|
| 2007 |
Bajénoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends in Immunology. 28: 346-52. PMID 17625969 DOI: 10.1016/J.It.2007.06.005 |
0.408 |
|
| 2007 |
Guarda G, Hons M, Soriano SF, Huang AY, Polley R, MartÃn-Fontecha A, Stein JV, Germain RN, Lanzavecchia A, Sallusto F. L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nature Immunology. 8: 743-52. PMID 17529983 DOI: 10.1038/Ni1469 |
0.432 |
|
| 2007 |
Castellino F, Germain RN. Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 778-87. PMID 17202339 DOI: 10.4049/Jimmunol.178.2.778 |
0.442 |
|
| 2006 |
Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. The Journal of Experimental Medicine. 203: 2841-52. PMID 17145958 DOI: 10.1084/Jem.20061884 |
0.391 |
|
| 2006 |
Bajénoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 25: 989-1001. PMID 17112751 DOI: 10.1016/J.Immuni.2006.10.011 |
0.437 |
|
| 2006 |
Meier-Schellersheim M, Xu X, Angermann B, Kunkel EJ, Jin T, Germain RN. Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. Plos Computational Biology. 2: e82. PMID 16854213 DOI: 10.1371/Journal.Pcbi.0020082 |
0.312 |
|
| 2006 |
Germain RN, Miller MJ, Dustin ML, Nussenzweig MC. Dynamic imaging of the immune system: Progress, pitfalls and promise Nature Reviews Immunology. 6: 497-507. PMID 16799470 DOI: 10.1038/Nri1884 |
0.415 |
|
| 2006 |
Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science (New York, N.Y.). 312: 1672-6. PMID 16778060 DOI: 10.1126/Science.1125703 |
0.453 |
|
| 2006 |
Benoist C, Germain RN, Mathis D. A plaidoyer for 'systems immunology'. Immunological Reviews. 210: 229-34. PMID 16623774 DOI: 10.1111/J.0105-2896.2006.00374.X |
0.357 |
|
| 2006 |
Castellino F, Huang AY, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature. 440: 890-5. PMID 16612374 DOI: 10.1038/Nature04651 |
0.732 |
|
| 2006 |
Castellino F, Germain RN. Cooperation between CD4+ and CD8+ T cells: when, where, and how. Annual Review of Immunology. 24: 519-40. PMID 16551258 DOI: 10.1146/Annurev.Immunol.23.021704.115825 |
0.51 |
|
| 2006 |
Bajénoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. The Journal of Experimental Medicine. 203: 619-31. PMID 16505138 DOI: 10.1084/Jem.20051474 |
0.49 |
|
| 2005 |
Itoh Y, Wang Z, Ishida H, Eichelberg K, Fujimoto N, Makino J, Ogasawara K, Germain RN. Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling. European Journal of Immunology. 35: 3187-95. PMID 16276482 DOI: 10.1002/Eji.200526064 |
0.395 |
|
| 2005 |
Altan-Bonnet G, Germain RN. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. Plos Biology. 3: e356. PMID 16231973 DOI: 10.1371/Journal.Pbio.0030356 |
0.701 |
|
| 2005 |
Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H. An extended vision for dynamic high-resolution intravital immune imaging. Seminars in Immunology. 17: 431-41. PMID 16216522 DOI: 10.1016/J.Smim.2005.09.003 |
0.405 |
|
| 2005 |
Fowlkes BJ, Germain RN, Leonard WJ, Paul WE, Samelson LE. A new year for immunity Immunity. 22: 1. DOI: 10.1016/J.Immuni.2005.01.001 |
0.356 |
|
| 2004 |
Germain RN. An innately interesting decade of research in immunology. Nature Medicine. 10: 1307-20. PMID 15580257 DOI: 10.1038/Nm1159 |
0.404 |
|
| 2004 |
Huang AY, Qi H, Germain RN. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity. 21: 331-9. PMID 15357944 DOI: 10.1016/J.Immuni.2004.08.001 |
0.354 |
|
| 2004 |
Faure S, Salazar-Fontana LI, Semichon M, Tybulewicz VL, Bismuth G, Trautmann A, Germain RN, Delon J. ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nature Immunology. 5: 272-9. PMID 14758359 DOI: 10.1038/Ni1039 |
0.478 |
|
| 2004 |
Germain RN, Jenkins MK. In vivo antigen presentation. Current Opinion in Immunology. 16: 120-5. PMID 14734120 DOI: 10.1016/J.Coi.2003.11.001 |
0.49 |
|
| 2004 |
Germain RN. Ligand-dependent regulation of T cell development and activation. Immunologic Research. 27: 277-86. PMID 12857974 DOI: 10.1385/Ir:27:2-3:277 |
0.501 |
|
| 2003 |
Mackey MF, Wang Z, Eichelberg K, Germain RN. Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion. European Journal of Immunology. 33: 779-89. PMID 12616498 DOI: 10.1002/Eji.200323729 |
0.349 |
|
| 2003 |
Stefanova I, Dorfman JR, Tsukamoto M, Germain RN. On the role of self-recognition in T cell responses to foreign antigen. Immunological Reviews. 191: 97-106. PMID 12614354 DOI: 10.1034/J.1600-065X.2003.00006.X |
0.488 |
|
| 2003 |
Germain RN. T-cell activation: the power of one. Current Biology : Cb. 13: R137-9. PMID 12593815 DOI: 10.1016/S0960-9822(03)00075-7 |
0.526 |
|
| 2003 |
Stefanová I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunology. 4: 248-54. PMID 12577055 DOI: 10.1038/Ni895 |
0.405 |
|
| 2003 |
Fowlkes BJ, Germain RN, Leonard WJ, Paul WE, Samelson LE. Casting a wider net Immunity. 18: 313. DOI: 10.1016/S1074-7613(03)00059-1 |
0.316 |
|
| 2002 |
Stefanová I, Dorfman JR, Germain RN. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature. 420: 429-34. PMID 12459785 DOI: 10.1038/Nature01146 |
0.494 |
|
| 2002 |
Delon J, Stoll S, Germain RN. Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue Immunological Reviews. 189: 51-63. PMID 12445265 DOI: 10.1034/J.1600-065X.2002.18906.X |
0.514 |
|
| 2002 |
Germain RN, Stefanova I, Dorfman J. Self-recognition and the regulation of CD4+ T cell survival. Advances in Experimental Medicine and Biology. 512: 97-105. PMID 12405192 DOI: 10.1007/978-1-4615-0757-4_13 |
0.456 |
|
| 2002 |
Scheinecker C, McHugh R, Shevach EM, Germain RN. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. The Journal of Experimental Medicine. 196: 1079-90. PMID 12391019 DOI: 10.1084/Jem.20020991 |
0.42 |
|
| 2002 |
Stoll S, Delon J, Brotz TM, Germain RN. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science (New York, N.Y.). 296: 1873-6. PMID 12052961 DOI: 10.1126/Science.1071065 |
0.487 |
|
| 2002 |
Germain RN. T-cell development and the CD4-CD8 lineage decision. Nature Reviews. Immunology. 2: 309-22. PMID 12033737 DOI: 10.1038/Nri798 |
0.411 |
|
| 2002 |
Dorfman JR, Germain RN. MHC-dependent survival of naïve T cells? A complicated answer to a simple question. Microbes and Infection / Institut Pasteur. 4: 547-54. PMID 11959510 DOI: 10.1016/S1286-4579(02)01571-X |
0.472 |
|
| 2001 |
Delon J, Kaibuchi K, Germain RN. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity. 15: 691-701. PMID 11728332 DOI: 10.1016/S1074-7613(01)00231-X |
0.332 |
|
| 2001 |
Germain RN. The art of the probable: system control in the adaptive immune system. Science (New York, N.Y.). 293: 240-5. PMID 11452112 DOI: 10.1126/Science.1062946 |
0.369 |
|
| 2001 |
Germain RN. The T cell receptor for antigen: signaling and ligand discrimination. The Journal of Biological Chemistry. 276: 35223-6. PMID 11435448 DOI: 10.1074/Jbc.R100025200 |
0.43 |
|
| 2001 |
Dorfman JR, Stefanová, Yasutomo K, Germain RN. Response to 'Class II essential for CD4 survival' Nature Immunology. 2: 136-137. PMID 11175807 DOI: 10.1038/84231 |
0.38 |
|
| 2001 |
Delon J, Germain RN. Information transfer at the immunological synapse. Current Biology : Cb. 10: R923-33. PMID 11137031 DOI: 10.1016/S0960-9822(00)00870-8 |
0.465 |
|
| 2000 |
Dorfman JR, Stefanová I, Yasutomo K, Germain RN. CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nature Immunology. 1: 329-35. PMID 11017105 DOI: 10.1038/79783 |
0.49 |
|
| 2000 |
Yasutomo K, Lucas B, Germain RN. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type. Journal of Immunology (Baltimore, Md. : 1950). 165: 3015-22. PMID 10975810 DOI: 10.4049/Jimmunol.165.6.3015 |
0.449 |
|
| 2000 |
Lucas B, Germain RN. Opening a window on thymic positive selection: developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced by TCR engagement. Journal of Immunology (Baltimore, Md. : 1950). 165: 1889-95. PMID 10925269 DOI: 10.4049/Jimmunol.165.4.1889 |
0.362 |
|
| 2000 |
Castellino F, Boucher PE, Eichelberg K, Mayhew M, Rothman JE, Houghton AN, Germain RN. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. The Journal of Experimental Medicine. 191: 1957-64. PMID 10839810 DOI: 10.1084/Jem.191.11.1957 |
0.435 |
|
| 2000 |
Yasutomo K, Doyle C, Miele L, Germain RN. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate Nature. 404: 506-510. PMID 10761920 DOI: 10.1038/35006664 |
0.433 |
|
| 2000 |
Inaba K, Turley S, Iyoda T, Yamaide F, Shimoyama S, Reis e Sousa C, Germain RN, Mellman I, Steinman RM. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. The Journal of Experimental Medicine. 191: 927-36. PMID 10727455 DOI: 10.1084/Jem.191.6.927 |
0.403 |
|
| 2000 |
Lu FW, Yasutomo K, Goodman GB, McHeyzer-Williams LJ, McHeyzer-Williams MG, Germain RN, Ashwell JD. Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire. Immunity. 12: 183-92. PMID 10714684 DOI: 10.1016/S1074-7613(00)80171-5 |
0.506 |
|
| 2000 |
Yasutomo K, Doyle C, Miele L, Fuchs C, Germain RN. Erratum: correction: The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate Nature. 407: 110-110. DOI: 10.1038/35024133 |
0.369 |
|
| 1999 |
Dittel BN, Štefanov́a I, Germain RN, Janeway CA. Cross-antagonism of a T cell clone expressing two distinct T cell receptors Immunity. 11: 289-298. PMID 10514007 DOI: 10.1016/S1074-7613(00)80104-1 |
0.46 |
|
| 1999 |
Germain RN, Stefanová I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annual Review of Immunology. 17: 467-522. PMID 10358766 DOI: 10.1146/Annurev.Immunol.17.1.467 |
0.437 |
|
| 1999 |
Lucas B, Stefanová I, Yasutomo K, Dautigny N, Germain RN. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity. 10: 367-76. PMID 10204492 DOI: 10.1016/S1074-7613(00)80036-9 |
0.448 |
|
| 1999 |
Sher A, Hieny S, Charest H, Scharton-Kersten T, Collazo C, Germain RN, Reis e Sousa C. The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii. Advances in Experimental Medicine and Biology. 452: 103-10. PMID 9889964 DOI: 10.1007/978-1-4615-5355-7_12 |
0.385 |
|
| 1998 |
Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP, Germain RN. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization Journal of Experimental Medicine. 188: 1075-1082. PMID 9743526 DOI: 10.1084/Jem.188.6.1075 |
0.45 |
|
| 1998 |
Sant'Angelo DB, Lucas B, Waterbury PG, Cohen B, Brabb T, Goverman J, Germain RN, Janeway CA. A molecular map of T cell development. Immunity. 9: 179-86. PMID 9729038 DOI: 10.1016/S1074-7613(00)80600-7 |
0.435 |
|
| 1998 |
Kim MG, Chen C, Flomerfelt FA, Germain RN, Schwartz RH. A subtractive PCR-based cDNA library made from fetal thymic stromal cells. Journal of Immunological Methods. 213: 169-82. PMID 9692849 DOI: 10.1016/S0022-1759(98)00031-3 |
0.362 |
|
| 1998 |
Combadière B, Reis e Sousa C, Germain RN, Lenardo MJ. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. The Journal of Experimental Medicine. 187: 349-55. PMID 9449715 DOI: 10.1084/Jem.187.3.349 |
0.477 |
|
| 1998 |
Zhong G, Reis e Sousa C, Germain RN. Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 13856-61. PMID 9391117 DOI: 10.1073/Pnas.94.25.13856 |
0.394 |
|
| 1998 |
Germain RN. T-cell signaling: the importance of receptor clustering. Current Biology : Cb. 7: R640-4. PMID 9368747 DOI: 10.1016/S0960-9822(06)00323-X |
0.426 |
|
| 1997 |
Reis e Sousa C, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. The Journal of Experimental Medicine. 186: 1819-29. PMID 9382881 DOI: 10.1084/Jem.186.11.1819 |
0.461 |
|
| 1997 |
Castellino F, Zhong G, Germain RN. Antigen presentation by MHC class II molecules: Invariant chain function, protein trafficking, and the molecular basis of diverse determinant capture Human Immunology. 54: 159-169. PMID 9297534 DOI: 10.1016/S0198-8859(97)00078-5 |
0.359 |
|
| 1997 |
Itoh Y, Germain RN. Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. The Journal of Experimental Medicine. 186: 757-66. PMID 9271591 DOI: 10.1084/Jem.186.5.757 |
0.491 |
|
| 1997 |
Zhong G, Reis e Sousa C, Germain RN. Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro. The Journal of Experimental Medicine. 186: 673-82. PMID 9271583 DOI: 10.1084/Jem.186.5.673 |
0.514 |
|
| 1997 |
Day PM, Yewdell JW, Porgador A, Germain RN, Bennink JR. Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 8064-9. PMID 9223315 DOI: 10.1073/Pnas.94.15.8064 |
0.333 |
|
| 1997 |
Porgador A, Yewdell JW, Deng Y, Bennink JR, Germain RN. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity. 6: 715-26. PMID 9208844 DOI: 10.1016/S1074-7613(00)80447-1 |
0.427 |
|
| 1997 |
Zhong G, Romagnoli P, Germain RN. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein Journal of Experimental Medicine. 185: 429-438. PMID 9053443 DOI: 10.1084/Jem.185.3.429 |
0.316 |
|
| 1997 |
van Meerwijk JP, Marguerat S, Lees RK, Germain RN, Fowlkes BJ, MacDonald HR. Quantitative impact of thymic clonal deletion on the T cell repertoire. The Journal of Experimental Medicine. 185: 377-83. PMID 9053438 DOI: 10.1084/Jem.185.3.377 |
0.44 |
|
| 1997 |
Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. The Journal of Experimental Medicine. 185: 219-29. PMID 9016871 DOI: 10.1084/Jem.185.2.219 |
0.418 |
|
| 1997 |
Lucas B, Germain RN. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity. 5: 461-77. PMID 8934573 DOI: 10.1016/S1074-7613(00)80502-6 |
0.328 |
|
| 1997 |
Huang LY, van Meerwijk JP, Bikoff EK, Germain RN. Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate. International Immunology. 8: 1429-40. PMID 8921421 DOI: 10.1093/Intimm/8.9.1429 |
0.416 |
|
| 1997 |
Madrenas J, Germain RN. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Seminars in Immunology. 8: 83-101. PMID 8920243 DOI: 10.1006/Smim.1996.0011 |
0.441 |
|
| 1997 |
Lucas B, Germain RN. T-cell repertoire: political correctness in the immune system. Current Biology : Cb. 6: 783-7. PMID 8805292 DOI: 10.1016/S0960-9822(02)00594-8 |
0.496 |
|
| 1996 |
Zhong G, Castellino F, Romagnoli P, Germain RN. Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP). The Journal of Experimental Medicine. 184: 2061-6. PMID 8920896 DOI: 10.1084/Jem.184.5.2061 |
0.312 |
|
| 1996 |
Madrenas J, Schwartz RH, Germain RN. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proceedings of the National Academy of Sciences of the United States of America. 93: 9736-41. PMID 8790400 DOI: 10.1073/Pnas.93.18.9736 |
0.429 |
|
| 1996 |
Germain RN. Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function. Seminars in Immunology. 7: 361-72. PMID 8775462 DOI: 10.1006/Smim.1995.0041 |
0.345 |
|
| 1996 |
Reis e Sousa C, Levine EH, Germain RN. Partial signaling by CD8+ T cells in response to antagonist ligands. The Journal of Experimental Medicine. 184: 149-57. PMID 8691128 DOI: 10.1084/Jem.184.1.149 |
0.442 |
|
| 1996 |
König R, Fleury S, Germain RN. The structural basis of CD4-MHC class II interactions: coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction. Current Topics in Microbiology and Immunology. 205: 19-46. PMID 8575196 DOI: 10.1007/978-3-642-79798-9_2 |
0.379 |
|
| 1995 |
van Meerwijk JP, Germain RN. The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection. Seminars in Immunology. 6: 231-9. PMID 8000032 DOI: 10.1006/Smim.1994.1030 |
0.359 |
|
| 1995 |
Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (New York, N.Y.). 267: 515-8. PMID 7824949 DOI: 10.1126/Science.7824949 |
0.376 |
|
| 1995 |
Marks MS, Germain RN, Bonifacino JS. Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells. The Journal of Biological Chemistry. 270: 10475-81. PMID 7737982 DOI: 10.1074/Jbc.270.18.10475 |
0.318 |
|
| 1995 |
Reis e Sousa C, Germain RN. Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. The Journal of Experimental Medicine. 182: 841-51. PMID 7650490 DOI: 10.1084/Jem.182.3.841 |
0.419 |
|
| 1995 |
König R, Shen X, Germain RN. Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation. The Journal of Experimental Medicine. 182: 779-87. PMID 7650484 DOI: 10.1084/Jem.182.3.779 |
0.386 |
|
| 1995 |
Germain RN. The biochemistry and cell biology of antigen presentation by MHC class I and class II molecules. Implications for development of combination vaccines. Annals of the New York Academy of Sciences. 754: 114-25. PMID 7625645 DOI: 10.1111/J.1749-6632.1995.Tb44444.X |
0.444 |
|
| 1995 |
Castellino F, Germain RN. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity. 2: 73-88. PMID 7600303 DOI: 10.1016/1074-7613(95)90080-2 |
0.344 |
|
| 1995 |
Racioppi L, Germain RN. Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. Chemical Immunology. 60: 79-99. DOI: 10.1159/000423972 |
0.468 |
|
| 1994 |
Germain RN. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 76: 287-99. PMID 8293464 DOI: 10.1016/0092-8674(94)90336-0 |
0.402 |
|
| 1994 |
Seder RA, Germain RN, Linsley PS, Paul WE. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. The Journal of Experimental Medicine. 179: 299-304. PMID 8270872 DOI: 10.1084/Jem.179.1.299 |
0.371 |
|
| 1994 |
Germain RN. Modern concepts in immune recognition and lymphocyte activation. Relevance for the development of useful vaccines. International Journal of Technology Assessment in Health Care. 10: 81-92. PMID 8157465 DOI: 10.1017/S026646230001401X |
0.448 |
|
| 1994 |
Sadegh-Nasseri S, Stern LJ, Wiley DC, Germain RN. MHC class II function preserved by low-affinity peptide interactions preceding stable binding. Nature. 370: 647-50. PMID 8065450 DOI: 10.1038/370647A0 |
0.654 |
|
| 1993 |
Germain RN, Rinker AG. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules. Nature. 363: 725-8. PMID 8515815 DOI: 10.1038/363725A0 |
0.362 |
|
| 1993 |
Hahn WC, Menzin E, Saito T, Germain RN, Bierer BE. The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines. Gene. 127: 267-8. PMID 8500769 DOI: 10.1016/0378-1119(93)90731-H |
0.315 |
|
| 1993 |
Germain RN, Margulies DH. The biochemistry and cell biology of antigen processing and presentation. Annual Review of Immunology. 11: 403-50. PMID 8476568 DOI: 10.1146/Annurev.Iy.11.040193.002155 |
0.373 |
|
| 1993 |
Racioppi L, Ronchese F, Matis LA, Germain RN. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. The Journal of Experimental Medicine. 177: 1047-60. PMID 8384651 DOI: 10.1084/Jem.177.4.1047 |
0.446 |
|
| 1993 |
van Meerwijk JP, Germain RN. Development of mature CD8+ thymocytes: selection rather than instruction? Science (New York, N.Y.). 261: 911-5. PMID 8102208 DOI: 10.1126/Science.8102208 |
0.417 |
|
| 1993 |
Bikoff EK, Huang LY, Episkopou V, van Meerwijk J, Germain RN, Robertson EJ. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. The Journal of Experimental Medicine. 177: 1699-712. PMID 8098731 DOI: 10.1084/Jem.177.6.1699 |
0.414 |
|
| 1992 |
König R, Huang LY, Germain RN. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8 Nature. 356: 796-798. PMID 1574118 DOI: 10.1038/356796A0 |
0.4 |
|
| 1992 |
Sadegh-Nasseri S, Germain RN. How MHC class II molecules work: peptide-dependent completion of protein folding Immunology Today. 13: 43-46. PMID 1533524 DOI: 10.1016/0167-5699(92)90131-P |
0.641 |
|
| 1992 |
Takahashi H, Nakagawa Y, Pendleton CD, Houghten RA, Yokomuro K, Germain RN, Berzofsky JA. Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science (New York, N.Y.). 255: 333-6. PMID 1372448 DOI: 10.1126/Science.1372448 |
0.371 |
|
| 1992 |
Kozlowski S, Corr M, Takeshita T, Boyd LF, Pendleton CD, Germain RN, Berzofsky JA, Margulies DH. Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules. The Journal of Experimental Medicine. 175: 1417-22. PMID 1316930 DOI: 10.1084/Jem.175.6.1417 |
0.388 |
|
| 1991 |
Kozlowski S, Takeshita T, Boehncke WH, Takahashi H, Boyd LF, Germain RN, Berzofsky JA, Margulies DH. Excess beta 2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules. Nature. 349: 74-7. PMID 1985269 DOI: 10.1038/349074A0 |
0.356 |
|
| 1991 |
Sant AJ, Hendrix LR, Coligan JE, Maloy WL, Germain RN. Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains. The Journal of Experimental Medicine. 174: 799-808. PMID 1919435 DOI: 10.1084/Jem.174.4.799 |
0.324 |
|
| 1991 |
Otten GR, Germain RN. Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science (New York, N.Y.). 251: 1228-31. PMID 1900952 DOI: 10.1126/Science.1900952 |
0.413 |
|
| 1991 |
Layet C, Germain RN. Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment. Proceedings of the National Academy of Sciences of the United States of America. 88: 2346-50. PMID 1900941 DOI: 10.1073/Pnas.88.6.2346 |
0.324 |
|
| 1991 |
Germain RN, Hendrix LR. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding Nature. 353: 134-139. PMID 1891045 DOI: 10.1038/353134A0 |
0.347 |
|
| 1991 |
Germain RN. Antigen presentation. The second class story. Nature. 353: 605-7. PMID 1833649 DOI: 10.1038/353605A0 |
0.319 |
|
| 1991 |
Bikoff EK, Jaffe L, Ribaudo RK, Otten GR, Germain RN, Robertson EJ. MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon. Nature. 354: 235-8. PMID 1720508 DOI: 10.1038/354235A0 |
0.331 |
|
| 1991 |
Sadegh-Nasseri S, Germain RN. A role for peptide in determining MHC class II structure Nature. 353: 167-170. PMID 1653903 DOI: 10.1038/353167A0 |
0.646 |
|
| 1990 |
Takahashi H, Houghten R, Putney SD, Margulies DH, Moss B, Germain RN, Berzofsky JA. Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. The Journal of Experimental Medicine. 170: 2023-35. PMID 2479705 DOI: 10.1084/Jem.170.6.2023 |
0.325 |
|
| 1990 |
Hosmalin A, Clerici M, Houghten R, Pendleton CD, Flexner C, Lucey DR, Moss B, Germain RN, Shearer GM, Berzofsky JA. An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 87: 2344-2348. PMID 1690429 DOI: 10.1073/Pnas.87.6.2344 |
0.427 |
|
| 1990 |
Takahashi H, Germain RN, Moss B, Berzofsky JA. An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself. The Journal of Experimental Medicine. 171: 571-6. PMID 1689366 DOI: 10.1084/Jem.171.2.571 |
0.408 |
|
| 1989 |
Takahashi H, Merli S, Putney SD, Houghten R, Moss B, Germain RN, Berzofsky JA. A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. Science (New York, N.Y.). 246: 118-21. PMID 2789433 DOI: 10.1126/Science.2789433 |
0.323 |
|
| 1989 |
Sant AJ, Germain RN. Intracellular competition for component chains determines class II MHC cell surface phenotype. Cell. 57: 797-805. PMID 2497991 DOI: 10.1016/0092-8674(89)90794-0 |
0.305 |
|
| 1989 |
Saito T, Germain RN. The molecular basis of MHC-restricted antigen recognition by T cells. International Reviews of Immunology. 3: 147-74. PMID 2469752 DOI: 10.3109/08830188809051187 |
0.463 |
|
| 1988 |
Sussman JJ, Mercép M, Saito T, Germain RN, Bonvini E, Ashwell JD. Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma Nature. 334: 625-628. PMID 3261394 DOI: 10.1038/334625A0 |
0.383 |
|
| 1988 |
Saito T, Hochstenbach F, Marusic-Galesic S, Kruisbeek AM, Brenner M, Germain RN. Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains. The Journal of Experimental Medicine. 168: 1003-20. PMID 2971751 DOI: 10.1084/Jem.168.3.1003 |
0.306 |
|
| 1988 |
Germain RN. Antigen processing and CD4+ T cell depletion in AIDS. Cell. 54: 441-4. PMID 2969773 DOI: 10.1016/0092-8674(88)90062-1 |
0.346 |
|
| 1988 |
Takahashi H, Cohen J, Hosmalin A, Cease KB, Houghten R, Cornette JL, DeLisi C, Moss B, Germain RN, Berzofsky JA. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility comples molecule-restricted murine cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 85: 3105-3109. PMID 2452443 DOI: 10.1073/Pnas.85.9.3105 |
0.399 |
|
| 1988 |
Saito T, Germain RN. The generation and selection of the T cell repertoire: insights from studies of the molecular basis of T cell recognition. Immunological Reviews. 101: 81-113. PMID 2450828 DOI: 10.1111/J.1600-065X.1988.Tb00733.X |
0.473 |
|
| 1988 |
Gunter KC, Germain RN, Leo O, Chan C, Shevach EM. Mitogenic activation of EL-4 cells does not require surface Thy-1 expression. Cellular Immunology. 112: 135-46. PMID 2449976 DOI: 10.1016/0008-8749(88)90282-1 |
0.454 |
|
| 1988 |
Fox BS, Carbone FR, Germain RN, Paterson Y, Schwartz RH. Processing of a minimal antigenic peptide alters its interaction with MHC molecules. Nature. 331: 538-40. PMID 2448649 DOI: 10.1038/331538A0 |
0.396 |
|
| 1987 |
McCluskey J, Singer A, Germain RN, Margulies DH. The role of CD4/L3T4 in T-lymphocyte function. Annales De L'Institut Pasteur. Immunology. 138: 150-7. PMID 3107588 DOI: 10.1016/S0769-2625(87)80108-3 |
0.361 |
|
| 1987 |
Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature. 326: 505-7. PMID 3104795 DOI: 10.1038/326505A0 |
0.439 |
|
| 1987 |
Ronchese F, Schwartz RH, Germain RN. Functionally distinct subsites on a class II major histocompatibility complex molecule. Nature. 329: 254-6. PMID 3041233 DOI: 10.1038/329254A0 |
0.42 |
|
| 1987 |
Braunstein NS, Germain RN. Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships. Proceedings of the National Academy of Sciences of the United States of America. 84: 2921-5. PMID 3033670 DOI: 10.1073/Pnas.84.9.2921 |
0.363 |
|
| 1987 |
Saito T, Weiss A, Miller J, Norcross MA, Germain RN. Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature. 325: 125-30. PMID 3027582 DOI: 10.1038/325125A0 |
0.418 |
|
| 1987 |
Stingl G, Gunter KC, Tschachler E, Yamada H, Lechler RI, Yokoyama WM, Steiner G, Germain RN, Shevach EM. Thy-1+ dendritic epidermal cells belong to the T-cell lineage. Proceedings of the National Academy of Sciences of the United States of America. 84: 2430-4. PMID 2882517 DOI: 10.1073/Pnas.84.8.2430 |
0.456 |
|
| 1987 |
Saito T, Germain RN. Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor beta-chain gene. Nature. 329: 256-9. PMID 2442621 DOI: 10.1038/329256A0 |
0.409 |
|
| 1986 |
Lew AM, Pardoll DM, Maloy WL, Fowlkes BJ, Kruisbeek A, Cheng SF, Germain RN, Bluestone JA, Schwartz RH, Coligan JE. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes Science. 234: 1401-1405. PMID 3787252 DOI: 10.1126/Science.3787252 |
0.45 |
|
| 1986 |
Germain RN. Immunology. The ins and outs of antigen processing and presentation. Nature. 322: 687-9. PMID 3489186 DOI: 10.1038/322687A0 |
0.307 |
|
| 1986 |
Brown MA, Glimcher LA, Nielsen EA, Paul WE, Germain RN. T-cell recognition of Ia molecules selectively altered by a single amino acid substitution. Science (New York, N.Y.). 231: 255-8. PMID 3484558 DOI: 10.1126/Science.3484558 |
0.424 |
|
| 1986 |
Miller J, Germain RN. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. The Journal of Experimental Medicine. 164: 1478-89. PMID 3464691 DOI: 10.1084/Jem.164.5.1478 |
0.403 |
|
| 1986 |
Germain RN, Quill H. Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L-cells. Nature. 320: 72-5. PMID 3456487 DOI: 10.1038/320072A0 |
0.311 |
|
| 1986 |
Kroczek RA, Gunter KC, Germain RN, Shevach EM. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Nature. 322: 181-4. PMID 2873512 DOI: 10.1038/322181A0 |
0.474 |
|
| 1986 |
Lechler RI, Ronchese F, Braunstein NS, Germain RN. I-A-restricted T cell antigen recognition. Analysis of the roles of A alpha and A beta using DNA-mediated gene transfer. The Journal of Experimental Medicine. 163: 678-96. PMID 2419471 DOI: 10.1084/Jem.163.3.678 |
0.346 |
|
| 1986 |
Gunter KC, Kroczek RA, Shevach EM, Germain RN. Functional expression of the murine Thy-1.2 gene in transfected human T cells. The Journal of Experimental Medicine. 163: 285-300. PMID 2418145 DOI: 10.1084/Jem.163.2.285 |
0.492 |
|
| 1985 |
Samelson LE, Lindsten T, Fowlkes BJ, Van den Elsen P, Terhorst C, Davis MM, Germain RN, Schwartz RH. Expression of genes of the T-cell antigen receptor complex in precursor thymocytes Nature. 315: 765-768. PMID 4010781 DOI: 10.1038/315765A0 |
0.471 |
|
| 1985 |
Golding H, McCluskey J, Munitz TI, Germain RN, Margulies DH, Singer A. T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4. Nature. 317: 425-7. PMID 3930971 DOI: 10.1038/317425A0 |
0.452 |
|
| 1985 |
Germain RN, Ashwell JD, Lechler RI, Margulies DH, Nickerson KM, Suzuki G, Tou JY. "Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proceedings of the National Academy of Sciences of the United States of America. 82: 2940-4. PMID 3921966 DOI: 10.1073/Pnas.82.9.2940 |
0.338 |
|
| 1985 |
Hedrick SM, Germain RN, Bevan MJ, Dorf M, Engel I, Fink P, Gascoigne N, Heber-Katz E, Kapp J, Kaufmann Y. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proceedings of the National Academy of Sciences of the United States of America. 82: 531-5. PMID 2578667 DOI: 10.1073/Pnas.82.2.531 |
0.333 |
|
| 1985 |
McCluskey J, Germain RN, Margulies DH. Cell surface expression of an in vitro recombinant class II/class I major histocompatibility complex gene product. Cell. 40: 247-57. PMID 2578320 DOI: 10.1016/0092-8674(85)90139-4 |
0.352 |
|
| 1984 |
Germain RN, Norcross MA, Margulies DH. Functional expression of a transfected murine class II MHC gene. Nature. 306: 190-4. PMID 6606131 DOI: 10.1038/306190A0 |
0.423 |
|
| 1984 |
Norcross MA, Bentley DM, Margulies DH, Germain RN. Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. Journal of Experimental Medicine. 160: 1316-1337. PMID 6436430 DOI: 10.1084/Jem.160.5.1316 |
0.465 |
|
| 1984 |
Samelson LE, Germain RN, Schwartz RH. Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proceedings of the National Academy of Sciences of the United States of America. 80: 6972-6. PMID 6316339 DOI: 10.1073/Pnas.80.22.6972 |
0.422 |
|
| 1983 |
Weinberger O, Germain RN, Burakoff SJ. Responses to the H-2Kba mutant involve recognition of syngeneic Ia molecules. Nature. 302: 429-31. PMID 6220226 DOI: 10.1038/302429A0 |
0.654 |
|
| 1981 |
Letvin NL, Benacerraf B, Germain RN. B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 5113-7. PMID 6975477 DOI: 10.1073/Pnas.78.8.5113 |
0.682 |
|
| 1981 |
Whitaker RB, Nepom JT, Sy MS, Takaoki M, Gramm CF, Fox I, Germain RN, Nelles MJ, Greene MI, Benacerraf B. Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate. Proceedings of the National Academy of Sciences of the United States of America. 78: 6441-5. PMID 6458813 DOI: 10.1073/Pnas.78.10.6441 |
0.567 |
|
| 1981 |
Sy MS, Nisonoff A, Germain RN, Benacerraf B, Greene MI. Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target. The Journal of Experimental Medicine. 153: 1415-25. PMID 6454748 DOI: 10.1084/Jem.153.6.1415 |
0.602 |
|
| 1981 |
Picus J, Germain RN, Fox IJ, Greene MI, Benacerraf B, Letvin NL. Immunologic effects of whole-body ultraviolet (uv) irradiation. III Defective splenic adherent cell function in alloantigen-stimulated T-cell proliferation. Cellular Immunology. 63: 300-7. PMID 6168395 DOI: 10.1016/0008-8749(81)90009-5 |
0.638 |
|
| 1981 |
Dietz MH, Sy MS, Benacerraf B, Nisonoff A, Greene MI, Germain RN. Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells. The Journal of Experimental Medicine. 153: 450-63. PMID 6165799 DOI: 10.1084/Jem.153.2.450 |
0.569 |
|
| 1981 |
Germain RN. Complementation of H-2 linked genetic defects in the production and function of antigen specific suppressor factor: implications for suppressor cell activation. Molecular Immunology. 17: 851-6. PMID 6163969 DOI: 10.1016/0161-5890(80)90033-4 |
0.412 |
|
| 1980 |
Letvin NL, Greene MI, Benacerraf B, Germain RN. Immunologic effects of whole-body ultraviolet irradiation: selective defect in splenic adherent cell function in vitro. Proceedings of the National Academy of Sciences of the United States of America. 77: 2881-5. PMID 6967214 DOI: 10.1073/Pnas.77.5.2881 |
0.611 |
|
| 1980 |
Germain RN, Benacerraf B. Helper and suppressor T cell factors. Springer Seminars in Immunopathology. 3: 93-127. PMID 6792727 DOI: 10.1007/BF00199927 |
0.49 |
|
| 1980 |
Germain RN, Waltenbaugh C, Benacerraf B. Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor. The Journal of Experimental Medicine. 151: 1245-59. PMID 6445400 DOI: 10.1084/Jem.151.5.1245 |
0.541 |
|
| 1980 |
Sy MS, Dietz MH, Germain RN, Benacerraf B, Greene MI. Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors. The Journal of Experimental Medicine. 151: 1183-95. PMID 6445398 DOI: 10.1084/Jem.151.5.1183 |
0.559 |
|
| 1980 |
Zubler RH, Benacerraf B, Germain RN. Feedback suppression of the immune response in vitro. II. IgVH-restricted antibody-dependent suppression. The Journal of Experimental Medicine. 151: 681-94. PMID 6444664 DOI: 10.1084/Jem.151.3.681 |
0.561 |
|
| 1980 |
Zubler RH, Cantor H, Benacerraf B, Germain RN. Feedback suppression of the immune response in vitro. I. Activity of antigen-stimulated B cells. The Journal of Experimental Medicine. 151: 667-80. PMID 6444663 DOI: 10.1084/Jem.151.3.667 |
0.594 |
|
| 1980 |
Weinberger JZ, Germain RN, Benacerraf B, Dorf ME. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway. The Journal of Experimental Medicine. 152: 161-9. PMID 6156980 DOI: 10.1084/Jem.152.1.161 |
0.551 |
|
| 1979 |
Ju ST, Pierres M, Waltenbaugh C, Germain RN, Benacerraf B, Dorf ME. Idiotypic analysis of monoclonal antibodies to poly(Glu60Ala30Tyr10). Proceedings of the National Academy of Sciences of the United States of America. 76: 2942-6. PMID 288079 DOI: 10.1073/Pnas.76.6.2942 |
0.413 |
|
| 1979 |
Germain RN, Ju ST, Kipps TJ, Benacerraf B, Dorf ME. Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10. The Journal of Experimental Medicine. 149: 613-22. PMID 107261 DOI: 10.1084/Jem.149.3.613 |
0.549 |
|
| 1979 |
Weinberger JZ, Germain RN, Ju ST, Greene MI, Benacerraf B, Dorf ME. Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. The Journal of Experimental Medicine. 150: 761-76. PMID 92517 DOI: 10.1084/Jem.150.4.761 |
0.555 |
|
| 1979 |
Pierres M, Ju ST, Waltenbaugh C, Dorf ME, Benacerraf B, Germain RN. Fine specificity of antibodies to poly(Glu60Ala30Tyr10) produced by hybrid cell lines. Proceedings of the National Academy of Sciences of the United States of America. 76: 2425-9. PMID 88055 DOI: 10.1073/Pnas.76.5.2425 |
0.46 |
|
| 1978 |
Germain RN, Benacerraf B. The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine. The Journal of Experimental Medicine. 148: 1324-37. PMID 102725 DOI: 10.1084/Jem.148.5.1324 |
0.505 |
|
| 1978 |
Pierres M, Germain RN, Dorf ME, Benacerraf B. In vivo effects of anti-Ia alloantisera. I. Elimination of specific suppression by in vivo administration of antisera specific for I-J controlled determinants. The Journal of Experimental Medicine. 147: 656-66. PMID 75939 DOI: 10.1084/Jem.147.3.656 |
0.485 |
|
| 1978 |
Germain RN, Thèze J, Kapp JA, Benacerraf B. Antigen-specific T-cell-mediated suppression. I. Induction of L-glutamic acid60-L-alanine30-L-tyrosine10 specific suppressor T cells in vitro requires both antigen-specific T-cell-suppressor factor and antigen. The Journal of Experimental Medicine. 147: 123-36. PMID 75231 DOI: 10.1084/Jem.147.1.123 |
0.572 |
|
| 1978 |
Benacerraf B, Germain RN. The immune response genes of the major histocompatibility complex. Immunological Reviews. 38: 70-119. PMID 75166 DOI: 10.1111/J.1600-065X.1978.Tb00385.X |
0.469 |
|
| 1977 |
Pierce CW, Germain RN, Kapp JA, Benacerraf B. Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages. The Journal of Experimental Medicine. 146: 1827-32. PMID 411879 DOI: 10.1084/JEM.146.6.1827 |
0.423 |
|
| 1977 |
Pierres M, Germain RN, Dorf ME, Benacerraf B. Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex. Proceedings of the National Academy of Sciences of the United States of America. 74: 3975-9. PMID 410029 DOI: 10.1073/Pnas.74.9.3975 |
0.483 |
|
| 1977 |
Thèze J, Waltenbaugh C, Germain RN, Benacerraf B. Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyosine50. IV. In vitro activity and immunochemical properties. European Journal of Immunology. 7: 705-10. PMID 73465 DOI: 10.1002/Eji.1830071011 |
0.454 |
|
| 1976 |
Burakoff SJ, Germain RN, Benacerraf B. Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells. The Journal of Experimental Medicine. 144: 1609-20. PMID 1087327 DOI: 10.1084/Jem.144.6.1609 |
0.653 |
|
| 1976 |
Burakoff SJ, Germain RN, Dorf ME, Benacerrah B. Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex. Proceedings of the National Academy of Sciences of the United States of America. 73: 625-9. PMID 1082140 DOI: 10.1073/Pnas.73.2.625 |
0.599 |
|
| 1975 |
Germain RN, Dorf ME, Benacerraf B. Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor. The Journal of Experimental Medicine. 142: 1023-8. PMID 809532 DOI: 10.1084/Jem.142.4.1023 |
0.545 |
|
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