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Ronald N Germain - Publications

Affiliations: 
LBS NIH/NIAID 
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Year Citation  Score
2023 Yayon N, Kedlian VR, Boehme L, Suo C, Wachter B, Beuschel RT, Amsalem O, Polanski K, Koplev S, Tuck E, Dann E, Van Hulle J, Perera S, Putteman T, Predeus AV, ... ... Germain RN, et al. A spatial human thymus cell atlas mapped to a continuous tissue axis. Biorxiv : the Preprint Server For Biology. PMID 37986877 DOI: 10.1101/2023.10.25.562925  0.302
2023 Chan W, Cao YM, Zhao X, Schrom EC, Jia D, Song J, Sibener LV, Dong S, Fernandes RA, Bradfield CJ, Smelkinson M, Kabat J, Hor JL, Altan-Bonnet G, Garcia KC, ... Germain RN, et al. TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. The Journal of Experimental Medicine. 220. PMID 37796477 DOI: 10.1084/jem.20231242  0.598
2023 Globig AM, Zhao S, Roginsky J, Maltez VI, Guiza J, Avina-Ochoa N, Heeg M, Araujo Hoffmann F, Chaudhary O, Wang J, Senturk G, Chen D, O'Connor C, Pfaff S, Germain RN, et al. The β-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. PMID 37731001 DOI: 10.1038/s41586-023-06568-6  0.381
2022 Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC. Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.). 376: eabl5282. PMID 35389803 DOI: 10.1126/science.abl5282  0.31
2021 Wong HS, Germain RN. Mesoscale T cell antigen discrimination emerges from intercellular feedback. Trends in Immunology. PMID 34493455 DOI: 10.1016/j.it.2021.08.006  0.398
2021 Wong HS, Park K, Gola A, Baptista AP, Miller CH, Deep D, Lou M, Boyd LF, Rudensky AY, Savage PA, Altan-Bonnet G, Tsang JS, Germain RN. A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell. PMID 34157301 DOI: 10.1016/j.cell.2021.05.028  0.69
2021 Russler-Germain EV, Yi J, Young S, Nutsch K, Wong HS, Ai TL, Chai JN, Durai V, Kaplan DH, Germain RN, Murphy KM, Hsieh CS. Gut presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation. Elife. 10. PMID 33533717 DOI: 10.7554/eLife.54792  0.371
2020 Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, ... ... Germain RN, et al. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. PMID 32362324 DOI: 10.1016/J.Immuni.2020.04.001  0.387
2020 Grant SM, Lou M, Yao L, Germain RN, Radtke AJ. The lymph node at a glance - how spatial organization optimizes the immune response. Journal of Cell Science. 133. PMID 32144196 DOI: 10.1242/Jcs.241828  0.434
2019 Germain RN. The Cellular Determinants of Adaptive Immunity. The New England Journal of Medicine. 381: 1083-1085. PMID 31502768 DOI: 10.1056/Nejmcibr1909387  0.3
2019 Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP. Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells. The Journal of Experimental Medicine. PMID 31405895 DOI: 10.1084/Jem.20181218  0.391
2019 Gottschalk RA, Dorrington MG, Dutta B, Krauss KS, Martins AJ, Uderhardt S, Chan W, Tsang JS, Torabi-Parizi P, Fraser ID, Germain RN. IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses. Elife. 8. PMID 31385572 DOI: 10.7554/Elife.46836  0.32
2019 Baptista AP, Gola A, Huang Y, Milanez-Almeida P, Torabi-Parizi P, Urban JF, Shapiro VS, Gerner MY, Germain RN. The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4 T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity. PMID 31053504 DOI: 10.1016/J.Immuni.2019.04.001  0.513
2019 Li W, Germain RN, Gerner MY. High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging. Nature Protocols. PMID 31028373 DOI: 10.1038/S41596-019-0156-4  0.305
2019 Uderhardt S, Martins AJ, Tsang JS, Lämmermann T, Germain RN. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. PMID 30955887 DOI: 10.1016/J.Cell.2019.02.028  0.31
2019 Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, ... Germain RN, et al. Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors. Science Immunology. 4. PMID 30824528 DOI: 10.1126/Sciimmunol.Aaw1941  0.321
2019 Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Quantifying in situ adaptive immune cell cognate interactions in humans. Nature Immunology. PMID 30778242 DOI: 10.1038/S41590-019-0315-3  0.503
2019 Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. PMID 30712876 DOI: 10.1016/J.Cell.2018.12.040  0.331
2019 Franco LM, Gadkari M, Howe KN, Sun J, Kardava L, Kumar P, Kumari S, Hu Z, Fraser IDC, Moir S, Tsang JS, Germain RN. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. The Journal of Experimental Medicine. PMID 30674564 DOI: 10.1084/Jem.20180595  0.396
2018 Germain RN, Huang Y. ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move? Current Opinion in Immunology. 56: 76-81. PMID 30472437 DOI: 10.1016/J.Coi.2018.11.001  0.478
2018 Huang Y, Mao K, Germain RN. Thinking differently about ILCs-Not just tissue resident and not just the same as CD4 T-cell effectors. Immunological Reviews. 286: 160-171. PMID 30294968 DOI: 10.1111/Imr.12704  0.495
2018 Gola A, Silman D, Walters AA, Sridhar S, Uderhardt S, Salman AM, Halbroth BR, Bellamy D, Bowyer G, Powlson J, Baker M, Venkatraman N, Poulton I, Berrie E, Roberts R, ... ... Germain RN, et al. Prime and target immunization protects against liver-stage malaria in mice. Science Translational Medicine. 10. PMID 30257955 DOI: 10.1126/Scitranslmed.Aap9128  0.339
2018 Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, ... ... Germain RN, et al. Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity. Nature Immunology. PMID 30127432 DOI: 10.1038/S41590-018-0182-3  0.443
2018 Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH. Spatial distribution and function of T follicular regulatory cells in human lymph nodes. The Journal of Experimental Medicine. PMID 29769249 DOI: 10.1084/Jem.20171940  0.479
2018 Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN. Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism. Nature. PMID 29364878 DOI: 10.1038/Nature25437  0.441
2018 Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF, Paul WE, Germain RN. S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. Science (New York, N.Y.). 359: 114-119. PMID 29302015 DOI: 10.1126/Science.Aam5809  0.379
2017 Wong HS, Germain RN. Robust control of the adaptive immune system. Seminars in Immunology. PMID 29290544 DOI: 10.1016/J.Smim.2017.12.009  0.437
2017 Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M. Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations. Immunity. 47: 862-874.e3. PMID 29166587 DOI: 10.1016/J.Immuni.2017.10.020  0.409
2017 Gerner MY, Casey KA, Kastenmuller W, Germain RN. Dendritic cell and antigen dispersal landscapes regulate T cell immunity. The Journal of Experimental Medicine. PMID 28847868 DOI: 10.1084/Jem.20170335  0.485
2017 Li W, Germain RN, Gerner MY. Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D). Proceedings of the National Academy of Sciences of the United States of America. PMID 28808033 DOI: 10.1073/Pnas.1708981114  0.332
2017 Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE. Memory-phenotype CD4(+) T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function. Science Immunology. 2. PMID 28783663 DOI: 10.1126/Sciimmunol.Aam9304  0.489
2017 Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ. Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells. The Journal of Experimental Medicine. PMID 28768709 DOI: 10.1084/Jem.20161955  0.457
2017 Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. PMID 28389069 DOI: 10.1016/J.Immuni.2017.03.011  0.74
2017 Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, et al. CD8 T Cells Orchestrate pDC-XCR1 Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity. 46: 205-219. PMID 28190711 DOI: 10.1016/J.Immuni.2017.01.003  0.473
2017 Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. The Journal of Experimental Medicine. PMID 28130403 DOI: 10.1084/Jem.20161318  0.513
2017 Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, ... ... Germain RN, et al. Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies. Science Translational Medicine. 9. PMID 28100833 DOI: 10.1126/Scitranslmed.Aag2285  0.392
2017 Radtke AJ, Anderson CF, Riteau N, Rausch K, Scaria P, Kelnhofer ER, Howard RF, Sher A, Germain RN, Duffy P. Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate. Scientific Reports. 7: 40312. PMID 28091576 DOI: 10.1038/Srep40312  0.353
2016 Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 27903737 DOI: 10.4049/Jimmunol.1601448  0.456
2016 Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, et al. Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy. Nature. PMID 27501248 DOI: 10.1038/Nature19330  0.433
2016 Gottschalk RA, Martins AJ, Angermann BR, Dutta B, Ng CE, Uderhardt S, Tsang JS, Fraser ID, Meier-Schellersheim M, Germain RN. Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses. Cell Systems. PMID 27237739 DOI: 10.1016/J.Cels.2016.04.016  0.313
2016 Liarski V, Sibley A, Panhuys Nv, Germain R, Giger M, Clark M. II-07 Generation of cell distance mapping plus (CDM+): mapping cognate T cell: dendritic cell interactions and their relationship to cell shape Lupus Science & Medicine. 3. DOI: 10.1136/Lupus-2016-000179.37  0.492
2015 Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. PMID 26605524 DOI: 10.1038/Nature16169  0.518
2015 Germain RN. Tracking the T cell repertoire. Nature Reviews. Immunology. 15: 730. PMID 26515079 DOI: 10.1038/Nri3922  0.43
2015 Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y. Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity. Cell. 163: 354-66. PMID 26451485 DOI: 10.1016/J.Cell.2015.08.030  0.323
2015 Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR. NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis. The Journal of Experimental Medicine. PMID 26347474 DOI: 10.1084/Jem.20141678  0.338
2015 Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W. Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions. Cell. 162: 1322-37. PMID 26296422 DOI: 10.1016/J.Cell.2015.08.004  0.503
2015 Manes NP, Angermann BR, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A. Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. Molecular & Cellular Proteomics : McP. 14: 2661-81. PMID 26199343 DOI: 10.1074/Mcp.M115.048918  0.301
2015 Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metabolism. 21: 543-57. PMID 25863247 DOI: 10.1016/J.Cmet.2015.03.005  0.466
2015 Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP, Cockburn IA. Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. Plos Pathogens. 11: e1004637. PMID 25658939 DOI: 10.1371/Journal.Ppat.1004637  0.438
2015 Subramanian N, Torabi-Parizi P, Gottschalk RA, Germain RN, Dutta B. Network representations of immune system complexity. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 7: 13-38. PMID 25625853 DOI: 10.1002/Wsbm.1288  0.327
2015 Gerner MY, Torabi-Parizi P, Germain RN. Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens. Immunity. 42: 172-85. PMID 25607462 DOI: 10.1016/J.Immuni.2014.12.024  0.468
2015 Liarski VM, Yanez D, Panhuys Nv, Germain R, Lan L, Giger M, Clark M. THU0374 Use and Validation of Cell Distance Mapping (CDM) in Studying the Pathogenesis of Tubulointerstitial Inflammation in Human Lupus Nephritis Annals of the Rheumatic Diseases. 74: 331-332. DOI: 10.1136/Annrheumdis-2015-Eular.5122  0.48
2014 Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, ... Germain RN, et al. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. The Journal of Experimental Medicine. 211: 2549-66. PMID 25422492 DOI: 10.1084/Jem.20141307  0.401
2014 Clatworthy MR, Aronin CE, Mathews RJ, Morgan NY, Smith KG, Germain RN. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nature Medicine. 20: 1458-63. PMID 25384086 DOI: 10.1038/Nm.3709  0.375
2014 Hodes RJ, Germain RN, Bluestone JA. The regulation of the immune system. Immunology Today. 5: 279-85. PMID 25290540 DOI: 10.1016/0167-5699(84)90145-2  0.328
2014 Qi H, Kastenmüller W, Germain RN. Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology. 30: 141-67. PMID 25150013 DOI: 10.1146/Annurev-Cellbio-100913-013254  0.455
2014 Vrisekoop N, Monteiro JP, Mandl JN, Germain RN. Revisiting thymic positive selection and the mature T cell repertoire for antigen. Immunity. 41: 181-90. PMID 25148022 DOI: 10.1016/J.Immuni.2014.07.007  0.493
2014 van Panhuys N, Klauschen F, Germain RN. T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. Immunity. 41: 63-74. PMID 24981853 DOI: 10.1016/j.immuni.2014.06.003  0.41
2014 Mandl JN, Germain RN. Focusing in on T cell cross-reactivity. Cell. 157: 1006-8. PMID 24855938 DOI: 10.1016/J.Cell.2014.05.002  0.475
2014 Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F, et al. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell. 157: 499-513. PMID 24725414 DOI: 10.1016/J.Cell.2014.03.031  0.366
2014 Mandl JN, Torabi-Parizi P, Germain RN. Visualization and dynamic analysis of host-pathogen interactions. Current Opinion in Immunology. 29: 8-15. PMID 24705104 DOI: 10.1016/J.Coi.2014.03.002  0.448
2014 Lämmermann T, Germain RN. The multiple faces of leukocyte interstitial migration. Seminars in Immunopathology. 36: 227-51. PMID 24573488 DOI: 10.1007/S00281-014-0418-8  0.372
2014 Germain RN. Open questions: a rose is a rose is a rose--or not? Bmc Biology. 12: 2. PMID 24484903 DOI: 10.1186/1741-7007-12-2  0.466
2014 Honda T, Egen JG, Lämmermann T, Kastenmüller W, Torabi-Parizi P, Germain RN. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity. 40: 235-247. PMID 24440150 DOI: 10.1016/J.Immuni.2013.11.017  0.499
2014 Torabi-Parizi P, Vrisekoop N, Kastenmuller W, Gerner MY, Egen JG, Germain RN. Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung. Journal of Immunology (Baltimore, Md. : 1950). 192: 1651-60. PMID 24431231 DOI: 10.4049/Jimmunol.1301743  0.444
2014 Petrovas C, Ferrando-Martinez S, Pegu A, Boswell K, Asokan M, Ambrozak D, Kotlyar D, Gerson M, Germain R, Reyes-Teran G, del Rio P, Docobo F, Leal M, Ruiz-Mateos E, Koup RA. B-108 Germinal center CD8 T cells can be redirected to eliminate HIV-expressing T follicular helper cells Jaids Journal of Acquired Immune Deficiency Syndromes. 67: 47. DOI: 10.1097/01.Qai.0000456074.83556.A7  0.423
2013 Lämmermann T, Afonso PV, Angermann BR, Wang JM, Kastenmüller W, Parent CA, Germain RN. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature. 498: 371-5. PMID 23708969 DOI: 10.1038/Nature12175  0.338
2013 Tang J, van Panhuys N, Kastenmüller W, Germain RN. The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful. European Journal of Immunology. 43: 1407-12. PMID 23568494 DOI: 10.1002/Eji.201243119  0.397
2013 Kastenmüller W, Brandes M, Wang Z, Herz J, Egen JG, Germain RN. Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. Immunity. 38: 502-13. PMID 23352234 DOI: 10.1016/J.Immuni.2012.11.012  0.396
2013 Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada GH, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M. Dynamic visualization of RANKL and Th17-mediated osteoclast function. The Journal of Clinical Investigation. 123: 866-73. PMID 23321670 DOI: 10.1172/Jci65054  0.355
2013 Mandl JN, Monteiro JP, Vrisekoop N, Germain RN. T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity. 38: 263-74. PMID 23290521 DOI: 10.1016/J.Immuni.2012.09.011  0.501
2013 Gottschalk RA, Martins AJ, Sjoelund VH, Angermann BR, Lin B, Germain RN. Recent progress using systems biology approaches to better understand molecular mechanisms of immunity. Seminars in Immunology. 25: 201-8. PMID 23238271 DOI: 10.1016/J.Smim.2012.11.002  0.329
2013 Honda T, Egen J, Germain R. Regulation of TCR-induced stop signal and T cell-effector function in peripheral tissue through PD-L1-PD-1 signaling Journal of Dermatological Science. 69: e68. DOI: 10.1016/J.Jdermsci.2012.11.510  0.309
2012 Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY, Germain RN. Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 18036-41. PMID 23071319 DOI: 10.1073/Pnas.1211717109  0.452
2012 Germain RN. Maintaining system homeostasis: the third law of Newtonian immunology. Nature Immunology. 13: 902-6. PMID 22990887 DOI: 10.1038/Ni.2404  0.325
2012 Kastenmüller W, Torabi-Parizi P, Subramanian N, Lämmermann T, Germain RN. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell. 150: 1235-48. PMID 22980983 DOI: 10.1016/J.Cell.2012.07.021  0.411
2012 Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, ... ... Germain RN, et al. CD4 T follicular helper cell dynamics during SIV infection. The Journal of Clinical Investigation. 122: 3281-94. PMID 22922258 DOI: 10.1172/Jci63039  0.468
2012 Gerner MY, Kastenmuller W, Ifrim I, Kabat J, Germain RN. Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes. Immunity. 37: 364-76. PMID 22863836 DOI: 10.1016/J.Immuni.2012.07.011  0.355
2012 Lee M, Mandl JN, Germain RN, Yates AJ. The race for the prize: T-cell trafficking strategies for optimal surveillance. Blood. 120: 1432-8. PMID 22773385 DOI: 10.1182/Blood-2012-04-424655  0.421
2012 Germain RN, Robey EA, Cahalan MD. A decade of imaging cellular motility and interaction dynamics in the immune system. Science (New York, N.Y.). 336: 1676-81. PMID 22745423 DOI: 10.1126/Science.1221063  0.448
2012 Gaiser MR, Lämmermann T, Feng X, Igyarto BZ, Kaplan DH, Tessarollo L, Germain RN, Udey MC. Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: E889-97. PMID 22411813 DOI: 10.1073/Pnas.1117674109  0.413
2011 Germain RN, Burakoff SJ. A remembrance of Baruj Benacerraf (AAI '57) 1920-2011. Journal of Immunology (Baltimore, Md. : 1950). 187: 5465-9. PMID 22102728 DOI: 10.4049/Jimmunol.1190069  0.46
2011 Mionnet C, Sanos SL, Mondor I, Jorquera A, Laugier JP, Germain RN, Bajénoff M. High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes. Blood. 118: 6115-22. PMID 21937697 DOI: 10.1182/Blood-2011-07-367409  0.311
2011 Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. Journal of Immunology (Baltimore, Md. : 1950). 187: 3186-97. PMID 21849683 DOI: 10.4049/Jimmunol.1101649  0.482
2011 Germain RN. Uncovering the role of invariant chain in controlling MHC class II antigen capture. Journal of Immunology (Baltimore, Md. : 1950). 187: 1073-5. PMID 21772033 DOI: 10.4049/Jimmunol.1101663  0.337
2011 Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity. 34: 807-19. PMID 21596592 DOI: 10.1016/J.Immuni.2011.03.022  0.52
2011 Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ, Kaplan DH, Kastenmüller W, Germain RN, Seder RA. Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. The Journal of Clinical Investigation. 121: 1782-96. PMID 21540549 DOI: 10.1172/Jci45416  0.429
2010 Germain RN. Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future. Febs Letters. 584: 4814-22. PMID 20965176 DOI: 10.1016/J.Febslet.2010.10.027  0.414
2010 Kastenmüller W, Gerner MY, Germain RN. The in situ dynamics of dendritic cell interactions. European Journal of Immunology. 40: 2103-6. PMID 20853494 DOI: 10.1002/Eji.201040482  0.435
2010 Coward J, Germain RN, Altan-Bonnet G. Perspectives for computer modeling in the study of T cell activation. Cold Spring Harbor Perspectives in Biology. 2: a005538. PMID 20516137 DOI: 10.1101/Cshperspect.A005538  0.715
2010 Cannons JL, Qi H, Lu KT, Dutta M, Gomez-Rodriguez J, Cheng J, Wakeland EK, Germain RN, Schwartzberg PL. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity. 32: 253-65. PMID 20153220 DOI: 10.1016/J.Immuni.2010.01.010  0.499
2010 Klauschen F, Meier-Schellersheim M, Mandl J, Qi H, Ishii M, Dietel M, Germain RN, Denkert C. Abstract 98: Automated cell tracking and interaction analysis in intra-vital two-photon microscopy image data Cancer Research. 70: 98-98. DOI: 10.1158/1538-7445.Am10-98  0.403
2009 Vrisekoop N, Mandl JN, Germain RN. Life and death as a T lymphocyte: from immune protection to HIV pathogenesis. Journal of Biology. 8: 91. PMID 19951397 DOI: 10.1186/Jbiol198  0.421
2009 Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, ... ... Germain RN, et al. Visualization and identification of IL-7 producing cells in reporter mice. Plos One. 4: e7637. PMID 19907640 DOI: 10.1371/Journal.Pone.0007637  0.31
2009 Bajénoff M, Germain RN. B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood. 114: 4989-97. PMID 19713459 DOI: 10.1182/Blood-2009-06-229567  0.439
2009 Klauschen F, Ishii M, Qi H, Bajénoff M, Egen JG, Germain RN, Meier-Schellersheim M. Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nature Protocols. 4: 1305-11. PMID 19696749 DOI: 10.1038/Nprot.2009.129  0.308
2009 Mueller SN, Germain RN. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Reviews. Immunology. 9: 618-29. PMID 19644499 DOI: 10.1038/Nri2588  0.413
2009 Klauschen F, Qi H, Egen JG, Germain RN, Meier-Schellersheim M. Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nature Protocols. 4: 1006-12. PMID 19536268 DOI: 10.1038/Nprot.2009.94  0.303
2009 Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nature Medicine. 15: 410-6. PMID 19330007 DOI: 10.1038/Nm.1946  0.403
2009 Fraser ID, Germain RN. Navigating the network: signaling cross-talk in hematopoietic cells. Nature Immunology. 10: 327-31. PMID 19295628 DOI: 10.1038/Ni.1711  0.309
2008 Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature. 455: 764-9. PMID 18843362 DOI: 10.1038/Nature07345  0.505
2008 Bajénoff M, Glaichenhaus N, Germain RN. Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone. Journal of Immunology (Baltimore, Md. : 1950). 181: 3947-54. PMID 18768849 DOI: 10.4049/Jimmunol.181.6.3947  0.439
2008 Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science (New York, N.Y.). 321: 1081-4. PMID 18719282 DOI: 10.1126/Science.1158013  0.805
2008 O'Shea JJ, Hunter CA, Germain RN. T cell heterogeneity: Firmly fixed, predominantly plastic or merely malleable? Nature Immunology. 9: 450-453. PMID 18425095 DOI: 10.1038/Ni0508-450  0.423
2008 Germain RN, Bajénoff M, Castellino F, Chieppa M, Egen JG, Huang AY, Ishii M, Koo LY, Qi H. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews. 221: 163-81. PMID 18275481 DOI: 10.1111/J.1600-065X.2008.00591.X  0.382
2008 Egen JG, Rothfuchs AG, Feng CG, Winter N, Sher A, Germain RN. Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity. 28: 271-84. PMID 18261937 DOI: 10.1016/J.Immuni.2007.12.010  0.447
2008 Germain RN. Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm. Immunology. 123: 20-7. PMID 18154615 DOI: 10.1111/J.1365-2567.2007.02779.X  0.491
2008 Bajénoff M, Germain RN. Seeing is believing: a focus on the contribution of microscopic imaging to our understanding of immune system function. European Journal of Immunology. S18-33. PMID 17972341 DOI: 10.1002/Eji.200737663  0.405
2008 Feinerman O, Germain RN, Altan-Bonnet G. Quantitative challenges in understanding ligand discrimination by alphabeta T cells. Molecular Immunology. 45: 619-31. PMID 17825415 DOI: 10.1016/J.Molimm.2007.03.028  0.789
2007 Bajénoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends in Immunology. 28: 346-52. PMID 17625969 DOI: 10.1016/J.It.2007.06.005  0.408
2007 Guarda G, Hons M, Soriano SF, Huang AY, Polley R, Martín-Fontecha A, Stein JV, Germain RN, Lanzavecchia A, Sallusto F. L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nature Immunology. 8: 743-52. PMID 17529983 DOI: 10.1038/Ni1469  0.432
2007 Castellino F, Germain RN. Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 778-87. PMID 17202339 DOI: 10.4049/Jimmunol.178.2.778  0.442
2006 Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. The Journal of Experimental Medicine. 203: 2841-52. PMID 17145958 DOI: 10.1084/Jem.20061884  0.391
2006 Bajénoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 25: 989-1001. PMID 17112751 DOI: 10.1016/J.Immuni.2006.10.011  0.437
2006 Meier-Schellersheim M, Xu X, Angermann B, Kunkel EJ, Jin T, Germain RN. Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. Plos Computational Biology. 2: e82. PMID 16854213 DOI: 10.1371/Journal.Pcbi.0020082  0.312
2006 Germain RN, Miller MJ, Dustin ML, Nussenzweig MC. Dynamic imaging of the immune system: Progress, pitfalls and promise Nature Reviews Immunology. 6: 497-507. PMID 16799470 DOI: 10.1038/Nri1884  0.415
2006 Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science (New York, N.Y.). 312: 1672-6. PMID 16778060 DOI: 10.1126/Science.1125703  0.453
2006 Benoist C, Germain RN, Mathis D. A plaidoyer for 'systems immunology'. Immunological Reviews. 210: 229-34. PMID 16623774 DOI: 10.1111/J.0105-2896.2006.00374.X  0.357
2006 Castellino F, Huang AY, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature. 440: 890-5. PMID 16612374 DOI: 10.1038/Nature04651  0.732
2006 Castellino F, Germain RN. Cooperation between CD4+ and CD8+ T cells: when, where, and how. Annual Review of Immunology. 24: 519-40. PMID 16551258 DOI: 10.1146/Annurev.Immunol.23.021704.115825  0.51
2006 Bajénoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. The Journal of Experimental Medicine. 203: 619-31. PMID 16505138 DOI: 10.1084/Jem.20051474  0.49
2005 Itoh Y, Wang Z, Ishida H, Eichelberg K, Fujimoto N, Makino J, Ogasawara K, Germain RN. Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling. European Journal of Immunology. 35: 3187-95. PMID 16276482 DOI: 10.1002/Eji.200526064  0.395
2005 Altan-Bonnet G, Germain RN. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. Plos Biology. 3: e356. PMID 16231973 DOI: 10.1371/Journal.Pbio.0030356  0.701
2005 Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H. An extended vision for dynamic high-resolution intravital immune imaging. Seminars in Immunology. 17: 431-41. PMID 16216522 DOI: 10.1016/J.Smim.2005.09.003  0.405
2005 Fowlkes BJ, Germain RN, Leonard WJ, Paul WE, Samelson LE. A new year for immunity Immunity. 22: 1. DOI: 10.1016/J.Immuni.2005.01.001  0.356
2004 Germain RN. An innately interesting decade of research in immunology. Nature Medicine. 10: 1307-20. PMID 15580257 DOI: 10.1038/Nm1159  0.404
2004 Huang AY, Qi H, Germain RN. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity. 21: 331-9. PMID 15357944 DOI: 10.1016/J.Immuni.2004.08.001  0.354
2004 Faure S, Salazar-Fontana LI, Semichon M, Tybulewicz VL, Bismuth G, Trautmann A, Germain RN, Delon J. ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nature Immunology. 5: 272-9. PMID 14758359 DOI: 10.1038/Ni1039  0.478
2004 Germain RN, Jenkins MK. In vivo antigen presentation. Current Opinion in Immunology. 16: 120-5. PMID 14734120 DOI: 10.1016/J.Coi.2003.11.001  0.49
2004 Germain RN. Ligand-dependent regulation of T cell development and activation. Immunologic Research. 27: 277-86. PMID 12857974 DOI: 10.1385/Ir:27:2-3:277  0.501
2003 Mackey MF, Wang Z, Eichelberg K, Germain RN. Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion. European Journal of Immunology. 33: 779-89. PMID 12616498 DOI: 10.1002/Eji.200323729  0.349
2003 Stefanova I, Dorfman JR, Tsukamoto M, Germain RN. On the role of self-recognition in T cell responses to foreign antigen. Immunological Reviews. 191: 97-106. PMID 12614354 DOI: 10.1034/J.1600-065X.2003.00006.X  0.488
2003 Germain RN. T-cell activation: the power of one. Current Biology : Cb. 13: R137-9. PMID 12593815 DOI: 10.1016/S0960-9822(03)00075-7  0.526
2003 Stefanová I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunology. 4: 248-54. PMID 12577055 DOI: 10.1038/Ni895  0.405
2003 Fowlkes BJ, Germain RN, Leonard WJ, Paul WE, Samelson LE. Casting a wider net Immunity. 18: 313. DOI: 10.1016/S1074-7613(03)00059-1  0.316
2002 Stefanová I, Dorfman JR, Germain RN. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature. 420: 429-34. PMID 12459785 DOI: 10.1038/Nature01146  0.494
2002 Delon J, Stoll S, Germain RN. Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue Immunological Reviews. 189: 51-63. PMID 12445265 DOI: 10.1034/J.1600-065X.2002.18906.X  0.514
2002 Germain RN, Stefanova I, Dorfman J. Self-recognition and the regulation of CD4+ T cell survival. Advances in Experimental Medicine and Biology. 512: 97-105. PMID 12405192 DOI: 10.1007/978-1-4615-0757-4_13  0.456
2002 Scheinecker C, McHugh R, Shevach EM, Germain RN. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. The Journal of Experimental Medicine. 196: 1079-90. PMID 12391019 DOI: 10.1084/Jem.20020991  0.42
2002 Stoll S, Delon J, Brotz TM, Germain RN. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science (New York, N.Y.). 296: 1873-6. PMID 12052961 DOI: 10.1126/Science.1071065  0.487
2002 Germain RN. T-cell development and the CD4-CD8 lineage decision. Nature Reviews. Immunology. 2: 309-22. PMID 12033737 DOI: 10.1038/Nri798  0.411
2002 Dorfman JR, Germain RN. MHC-dependent survival of naïve T cells? A complicated answer to a simple question. Microbes and Infection / Institut Pasteur. 4: 547-54. PMID 11959510 DOI: 10.1016/S1286-4579(02)01571-X  0.472
2001 Delon J, Kaibuchi K, Germain RN. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity. 15: 691-701. PMID 11728332 DOI: 10.1016/S1074-7613(01)00231-X  0.332
2001 Germain RN. The art of the probable: system control in the adaptive immune system. Science (New York, N.Y.). 293: 240-5. PMID 11452112 DOI: 10.1126/Science.1062946  0.369
2001 Germain RN. The T cell receptor for antigen: signaling and ligand discrimination. The Journal of Biological Chemistry. 276: 35223-6. PMID 11435448 DOI: 10.1074/Jbc.R100025200  0.43
2001 Dorfman JR, Stefanová, Yasutomo K, Germain RN. Response to 'Class II essential for CD4 survival' Nature Immunology. 2: 136-137. PMID 11175807 DOI: 10.1038/84231  0.38
2001 Delon J, Germain RN. Information transfer at the immunological synapse. Current Biology : Cb. 10: R923-33. PMID 11137031 DOI: 10.1016/S0960-9822(00)00870-8  0.465
2000 Dorfman JR, Stefanová I, Yasutomo K, Germain RN. CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nature Immunology. 1: 329-35. PMID 11017105 DOI: 10.1038/79783  0.49
2000 Yasutomo K, Lucas B, Germain RN. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type. Journal of Immunology (Baltimore, Md. : 1950). 165: 3015-22. PMID 10975810 DOI: 10.4049/Jimmunol.165.6.3015  0.449
2000 Lucas B, Germain RN. Opening a window on thymic positive selection: developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced by TCR engagement. Journal of Immunology (Baltimore, Md. : 1950). 165: 1889-95. PMID 10925269 DOI: 10.4049/Jimmunol.165.4.1889  0.362
2000 Castellino F, Boucher PE, Eichelberg K, Mayhew M, Rothman JE, Houghton AN, Germain RN. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. The Journal of Experimental Medicine. 191: 1957-64. PMID 10839810 DOI: 10.1084/Jem.191.11.1957  0.435
2000 Yasutomo K, Doyle C, Miele L, Germain RN. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate Nature. 404: 506-510. PMID 10761920 DOI: 10.1038/35006664  0.433
2000 Inaba K, Turley S, Iyoda T, Yamaide F, Shimoyama S, Reis e Sousa C, Germain RN, Mellman I, Steinman RM. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. The Journal of Experimental Medicine. 191: 927-36. PMID 10727455 DOI: 10.1084/Jem.191.6.927  0.403
2000 Lu FW, Yasutomo K, Goodman GB, McHeyzer-Williams LJ, McHeyzer-Williams MG, Germain RN, Ashwell JD. Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire. Immunity. 12: 183-92. PMID 10714684 DOI: 10.1016/S1074-7613(00)80171-5  0.506
2000 Yasutomo K, Doyle C, Miele L, Fuchs C, Germain RN. Erratum: correction: The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate Nature. 407: 110-110. DOI: 10.1038/35024133  0.369
1999 Dittel BN, Štefanov́a I, Germain RN, Janeway CA. Cross-antagonism of a T cell clone expressing two distinct T cell receptors Immunity. 11: 289-298. PMID 10514007 DOI: 10.1016/S1074-7613(00)80104-1  0.46
1999 Germain RN, Stefanová I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annual Review of Immunology. 17: 467-522. PMID 10358766 DOI: 10.1146/Annurev.Immunol.17.1.467  0.437
1999 Lucas B, Stefanová I, Yasutomo K, Dautigny N, Germain RN. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity. 10: 367-76. PMID 10204492 DOI: 10.1016/S1074-7613(00)80036-9  0.448
1999 Sher A, Hieny S, Charest H, Scharton-Kersten T, Collazo C, Germain RN, Reis e Sousa C. The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii. Advances in Experimental Medicine and Biology. 452: 103-10. PMID 9889964 DOI: 10.1007/978-1-4615-5355-7_12  0.385
1998 Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP, Germain RN. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization Journal of Experimental Medicine. 188: 1075-1082. PMID 9743526 DOI: 10.1084/Jem.188.6.1075  0.45
1998 Sant'Angelo DB, Lucas B, Waterbury PG, Cohen B, Brabb T, Goverman J, Germain RN, Janeway CA. A molecular map of T cell development. Immunity. 9: 179-86. PMID 9729038 DOI: 10.1016/S1074-7613(00)80600-7  0.435
1998 Kim MG, Chen C, Flomerfelt FA, Germain RN, Schwartz RH. A subtractive PCR-based cDNA library made from fetal thymic stromal cells. Journal of Immunological Methods. 213: 169-82. PMID 9692849 DOI: 10.1016/S0022-1759(98)00031-3  0.362
1998 Combadière B, Reis e Sousa C, Germain RN, Lenardo MJ. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. The Journal of Experimental Medicine. 187: 349-55. PMID 9449715 DOI: 10.1084/Jem.187.3.349  0.477
1998 Zhong G, Reis e Sousa C, Germain RN. Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 13856-61. PMID 9391117 DOI: 10.1073/Pnas.94.25.13856  0.394
1998 Germain RN. T-cell signaling: the importance of receptor clustering. Current Biology : Cb. 7: R640-4. PMID 9368747 DOI: 10.1016/S0960-9822(06)00323-X  0.426
1997 Reis e Sousa C, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. The Journal of Experimental Medicine. 186: 1819-29. PMID 9382881 DOI: 10.1084/Jem.186.11.1819  0.461
1997 Castellino F, Zhong G, Germain RN. Antigen presentation by MHC class II molecules: Invariant chain function, protein trafficking, and the molecular basis of diverse determinant capture Human Immunology. 54: 159-169. PMID 9297534 DOI: 10.1016/S0198-8859(97)00078-5  0.359
1997 Itoh Y, Germain RN. Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. The Journal of Experimental Medicine. 186: 757-66. PMID 9271591 DOI: 10.1084/Jem.186.5.757  0.491
1997 Zhong G, Reis e Sousa C, Germain RN. Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro. The Journal of Experimental Medicine. 186: 673-82. PMID 9271583 DOI: 10.1084/Jem.186.5.673  0.514
1997 Day PM, Yewdell JW, Porgador A, Germain RN, Bennink JR. Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 8064-9. PMID 9223315 DOI: 10.1073/Pnas.94.15.8064  0.333
1997 Porgador A, Yewdell JW, Deng Y, Bennink JR, Germain RN. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity. 6: 715-26. PMID 9208844 DOI: 10.1016/S1074-7613(00)80447-1  0.427
1997 Zhong G, Romagnoli P, Germain RN. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein Journal of Experimental Medicine. 185: 429-438. PMID 9053443 DOI: 10.1084/Jem.185.3.429  0.316
1997 van Meerwijk JP, Marguerat S, Lees RK, Germain RN, Fowlkes BJ, MacDonald HR. Quantitative impact of thymic clonal deletion on the T cell repertoire. The Journal of Experimental Medicine. 185: 377-83. PMID 9053438 DOI: 10.1084/Jem.185.3.377  0.44
1997 Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. The Journal of Experimental Medicine. 185: 219-29. PMID 9016871 DOI: 10.1084/Jem.185.2.219  0.418
1997 Lucas B, Germain RN. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity. 5: 461-77. PMID 8934573 DOI: 10.1016/S1074-7613(00)80502-6  0.328
1997 Huang LY, van Meerwijk JP, Bikoff EK, Germain RN. Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate. International Immunology. 8: 1429-40. PMID 8921421 DOI: 10.1093/Intimm/8.9.1429  0.416
1997 Madrenas J, Germain RN. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Seminars in Immunology. 8: 83-101. PMID 8920243 DOI: 10.1006/Smim.1996.0011  0.441
1997 Lucas B, Germain RN. T-cell repertoire: political correctness in the immune system. Current Biology : Cb. 6: 783-7. PMID 8805292 DOI: 10.1016/S0960-9822(02)00594-8  0.496
1996 Zhong G, Castellino F, Romagnoli P, Germain RN. Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP). The Journal of Experimental Medicine. 184: 2061-6. PMID 8920896 DOI: 10.1084/Jem.184.5.2061  0.312
1996 Madrenas J, Schwartz RH, Germain RN. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proceedings of the National Academy of Sciences of the United States of America. 93: 9736-41. PMID 8790400 DOI: 10.1073/Pnas.93.18.9736  0.429
1996 Germain RN. Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function. Seminars in Immunology. 7: 361-72. PMID 8775462 DOI: 10.1006/Smim.1995.0041  0.345
1996 Reis e Sousa C, Levine EH, Germain RN. Partial signaling by CD8+ T cells in response to antagonist ligands. The Journal of Experimental Medicine. 184: 149-57. PMID 8691128 DOI: 10.1084/Jem.184.1.149  0.442
1996 König R, Fleury S, Germain RN. The structural basis of CD4-MHC class II interactions: coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction. Current Topics in Microbiology and Immunology. 205: 19-46. PMID 8575196 DOI: 10.1007/978-3-642-79798-9_2  0.379
1995 van Meerwijk JP, Germain RN. The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection. Seminars in Immunology. 6: 231-9. PMID 8000032 DOI: 10.1006/Smim.1994.1030  0.359
1995 Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (New York, N.Y.). 267: 515-8. PMID 7824949 DOI: 10.1126/Science.7824949  0.376
1995 Marks MS, Germain RN, Bonifacino JS. Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells. The Journal of Biological Chemistry. 270: 10475-81. PMID 7737982 DOI: 10.1074/Jbc.270.18.10475  0.318
1995 Reis e Sousa C, Germain RN. Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. The Journal of Experimental Medicine. 182: 841-51. PMID 7650490 DOI: 10.1084/Jem.182.3.841  0.419
1995 König R, Shen X, Germain RN. Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation. The Journal of Experimental Medicine. 182: 779-87. PMID 7650484 DOI: 10.1084/Jem.182.3.779  0.386
1995 Germain RN. The biochemistry and cell biology of antigen presentation by MHC class I and class II molecules. Implications for development of combination vaccines. Annals of the New York Academy of Sciences. 754: 114-25. PMID 7625645 DOI: 10.1111/J.1749-6632.1995.Tb44444.X  0.444
1995 Castellino F, Germain RN. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity. 2: 73-88. PMID 7600303 DOI: 10.1016/1074-7613(95)90080-2  0.344
1995 Racioppi L, Germain RN. Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. Chemical Immunology. 60: 79-99. DOI: 10.1159/000423972  0.468
1994 Germain RN. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 76: 287-99. PMID 8293464 DOI: 10.1016/0092-8674(94)90336-0  0.402
1994 Seder RA, Germain RN, Linsley PS, Paul WE. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. The Journal of Experimental Medicine. 179: 299-304. PMID 8270872 DOI: 10.1084/Jem.179.1.299  0.371
1994 Germain RN. Modern concepts in immune recognition and lymphocyte activation. Relevance for the development of useful vaccines. International Journal of Technology Assessment in Health Care. 10: 81-92. PMID 8157465 DOI: 10.1017/S026646230001401X  0.448
1994 Sadegh-Nasseri S, Stern LJ, Wiley DC, Germain RN. MHC class II function preserved by low-affinity peptide interactions preceding stable binding. Nature. 370: 647-50. PMID 8065450 DOI: 10.1038/370647A0  0.654
1993 Germain RN, Rinker AG. Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules. Nature. 363: 725-8. PMID 8515815 DOI: 10.1038/363725A0  0.362
1993 Hahn WC, Menzin E, Saito T, Germain RN, Bierer BE. The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines. Gene. 127: 267-8. PMID 8500769 DOI: 10.1016/0378-1119(93)90731-H  0.315
1993 Germain RN, Margulies DH. The biochemistry and cell biology of antigen processing and presentation. Annual Review of Immunology. 11: 403-50. PMID 8476568 DOI: 10.1146/Annurev.Iy.11.040193.002155  0.373
1993 Racioppi L, Ronchese F, Matis LA, Germain RN. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. The Journal of Experimental Medicine. 177: 1047-60. PMID 8384651 DOI: 10.1084/Jem.177.4.1047  0.446
1993 van Meerwijk JP, Germain RN. Development of mature CD8+ thymocytes: selection rather than instruction? Science (New York, N.Y.). 261: 911-5. PMID 8102208 DOI: 10.1126/Science.8102208  0.417
1993 Bikoff EK, Huang LY, Episkopou V, van Meerwijk J, Germain RN, Robertson EJ. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. The Journal of Experimental Medicine. 177: 1699-712. PMID 8098731 DOI: 10.1084/Jem.177.6.1699  0.414
1992 König R, Huang LY, Germain RN. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8 Nature. 356: 796-798. PMID 1574118 DOI: 10.1038/356796A0  0.4
1992 Sadegh-Nasseri S, Germain RN. How MHC class II molecules work: peptide-dependent completion of protein folding Immunology Today. 13: 43-46. PMID 1533524 DOI: 10.1016/0167-5699(92)90131-P  0.641
1992 Takahashi H, Nakagawa Y, Pendleton CD, Houghten RA, Yokomuro K, Germain RN, Berzofsky JA. Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science (New York, N.Y.). 255: 333-6. PMID 1372448 DOI: 10.1126/Science.1372448  0.371
1992 Kozlowski S, Corr M, Takeshita T, Boyd LF, Pendleton CD, Germain RN, Berzofsky JA, Margulies DH. Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules. The Journal of Experimental Medicine. 175: 1417-22. PMID 1316930 DOI: 10.1084/Jem.175.6.1417  0.388
1991 Kozlowski S, Takeshita T, Boehncke WH, Takahashi H, Boyd LF, Germain RN, Berzofsky JA, Margulies DH. Excess beta 2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules. Nature. 349: 74-7. PMID 1985269 DOI: 10.1038/349074A0  0.356
1991 Sant AJ, Hendrix LR, Coligan JE, Maloy WL, Germain RN. Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains. The Journal of Experimental Medicine. 174: 799-808. PMID 1919435 DOI: 10.1084/Jem.174.4.799  0.324
1991 Otten GR, Germain RN. Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science (New York, N.Y.). 251: 1228-31. PMID 1900952 DOI: 10.1126/Science.1900952  0.413
1991 Layet C, Germain RN. Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment. Proceedings of the National Academy of Sciences of the United States of America. 88: 2346-50. PMID 1900941 DOI: 10.1073/Pnas.88.6.2346  0.324
1991 Germain RN, Hendrix LR. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding Nature. 353: 134-139. PMID 1891045 DOI: 10.1038/353134A0  0.347
1991 Germain RN. Antigen presentation. The second class story. Nature. 353: 605-7. PMID 1833649 DOI: 10.1038/353605A0  0.319
1991 Bikoff EK, Jaffe L, Ribaudo RK, Otten GR, Germain RN, Robertson EJ. MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon. Nature. 354: 235-8. PMID 1720508 DOI: 10.1038/354235A0  0.331
1991 Sadegh-Nasseri S, Germain RN. A role for peptide in determining MHC class II structure Nature. 353: 167-170. PMID 1653903 DOI: 10.1038/353167A0  0.646
1990 Takahashi H, Houghten R, Putney SD, Margulies DH, Moss B, Germain RN, Berzofsky JA. Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. The Journal of Experimental Medicine. 170: 2023-35. PMID 2479705 DOI: 10.1084/Jem.170.6.2023  0.325
1990 Hosmalin A, Clerici M, Houghten R, Pendleton CD, Flexner C, Lucey DR, Moss B, Germain RN, Shearer GM, Berzofsky JA. An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 87: 2344-2348. PMID 1690429 DOI: 10.1073/Pnas.87.6.2344  0.427
1990 Takahashi H, Germain RN, Moss B, Berzofsky JA. An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself. The Journal of Experimental Medicine. 171: 571-6. PMID 1689366 DOI: 10.1084/Jem.171.2.571  0.408
1989 Takahashi H, Merli S, Putney SD, Houghten R, Moss B, Germain RN, Berzofsky JA. A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. Science (New York, N.Y.). 246: 118-21. PMID 2789433 DOI: 10.1126/Science.2789433  0.323
1989 Sant AJ, Germain RN. Intracellular competition for component chains determines class II MHC cell surface phenotype. Cell. 57: 797-805. PMID 2497991 DOI: 10.1016/0092-8674(89)90794-0  0.305
1989 Saito T, Germain RN. The molecular basis of MHC-restricted antigen recognition by T cells. International Reviews of Immunology. 3: 147-74. PMID 2469752 DOI: 10.3109/08830188809051187  0.463
1988 Sussman JJ, Mercép M, Saito T, Germain RN, Bonvini E, Ashwell JD. Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma Nature. 334: 625-628. PMID 3261394 DOI: 10.1038/334625A0  0.383
1988 Saito T, Hochstenbach F, Marusic-Galesic S, Kruisbeek AM, Brenner M, Germain RN. Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains. The Journal of Experimental Medicine. 168: 1003-20. PMID 2971751 DOI: 10.1084/Jem.168.3.1003  0.306
1988 Germain RN. Antigen processing and CD4+ T cell depletion in AIDS. Cell. 54: 441-4. PMID 2969773 DOI: 10.1016/0092-8674(88)90062-1  0.346
1988 Takahashi H, Cohen J, Hosmalin A, Cease KB, Houghten R, Cornette JL, DeLisi C, Moss B, Germain RN, Berzofsky JA. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility comples molecule-restricted murine cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 85: 3105-3109. PMID 2452443 DOI: 10.1073/Pnas.85.9.3105  0.399
1988 Saito T, Germain RN. The generation and selection of the T cell repertoire: insights from studies of the molecular basis of T cell recognition. Immunological Reviews. 101: 81-113. PMID 2450828 DOI: 10.1111/J.1600-065X.1988.Tb00733.X  0.473
1988 Gunter KC, Germain RN, Leo O, Chan C, Shevach EM. Mitogenic activation of EL-4 cells does not require surface Thy-1 expression. Cellular Immunology. 112: 135-46. PMID 2449976 DOI: 10.1016/0008-8749(88)90282-1  0.454
1988 Fox BS, Carbone FR, Germain RN, Paterson Y, Schwartz RH. Processing of a minimal antigenic peptide alters its interaction with MHC molecules. Nature. 331: 538-40. PMID 2448649 DOI: 10.1038/331538A0  0.396
1987 McCluskey J, Singer A, Germain RN, Margulies DH. The role of CD4/L3T4 in T-lymphocyte function. Annales De L'Institut Pasteur. Immunology. 138: 150-7. PMID 3107588 DOI: 10.1016/S0769-2625(87)80108-3  0.361
1987 Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature. 326: 505-7. PMID 3104795 DOI: 10.1038/326505A0  0.439
1987 Ronchese F, Schwartz RH, Germain RN. Functionally distinct subsites on a class II major histocompatibility complex molecule. Nature. 329: 254-6. PMID 3041233 DOI: 10.1038/329254A0  0.42
1987 Braunstein NS, Germain RN. Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships. Proceedings of the National Academy of Sciences of the United States of America. 84: 2921-5. PMID 3033670 DOI: 10.1073/Pnas.84.9.2921  0.363
1987 Saito T, Weiss A, Miller J, Norcross MA, Germain RN. Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature. 325: 125-30. PMID 3027582 DOI: 10.1038/325125A0  0.418
1987 Stingl G, Gunter KC, Tschachler E, Yamada H, Lechler RI, Yokoyama WM, Steiner G, Germain RN, Shevach EM. Thy-1+ dendritic epidermal cells belong to the T-cell lineage. Proceedings of the National Academy of Sciences of the United States of America. 84: 2430-4. PMID 2882517 DOI: 10.1073/Pnas.84.8.2430  0.456
1987 Saito T, Germain RN. Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor beta-chain gene. Nature. 329: 256-9. PMID 2442621 DOI: 10.1038/329256A0  0.409
1986 Lew AM, Pardoll DM, Maloy WL, Fowlkes BJ, Kruisbeek A, Cheng SF, Germain RN, Bluestone JA, Schwartz RH, Coligan JE. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes Science. 234: 1401-1405. PMID 3787252 DOI: 10.1126/Science.3787252  0.45
1986 Germain RN. Immunology. The ins and outs of antigen processing and presentation. Nature. 322: 687-9. PMID 3489186 DOI: 10.1038/322687A0  0.307
1986 Brown MA, Glimcher LA, Nielsen EA, Paul WE, Germain RN. T-cell recognition of Ia molecules selectively altered by a single amino acid substitution. Science (New York, N.Y.). 231: 255-8. PMID 3484558 DOI: 10.1126/Science.3484558  0.424
1986 Miller J, Germain RN. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. The Journal of Experimental Medicine. 164: 1478-89. PMID 3464691 DOI: 10.1084/Jem.164.5.1478  0.403
1986 Germain RN, Quill H. Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L-cells. Nature. 320: 72-5. PMID 3456487 DOI: 10.1038/320072A0  0.311
1986 Kroczek RA, Gunter KC, Germain RN, Shevach EM. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Nature. 322: 181-4. PMID 2873512 DOI: 10.1038/322181A0  0.474
1986 Lechler RI, Ronchese F, Braunstein NS, Germain RN. I-A-restricted T cell antigen recognition. Analysis of the roles of A alpha and A beta using DNA-mediated gene transfer. The Journal of Experimental Medicine. 163: 678-96. PMID 2419471 DOI: 10.1084/Jem.163.3.678  0.346
1986 Gunter KC, Kroczek RA, Shevach EM, Germain RN. Functional expression of the murine Thy-1.2 gene in transfected human T cells. The Journal of Experimental Medicine. 163: 285-300. PMID 2418145 DOI: 10.1084/Jem.163.2.285  0.492
1985 Samelson LE, Lindsten T, Fowlkes BJ, Van den Elsen P, Terhorst C, Davis MM, Germain RN, Schwartz RH. Expression of genes of the T-cell antigen receptor complex in precursor thymocytes Nature. 315: 765-768. PMID 4010781 DOI: 10.1038/315765A0  0.471
1985 Golding H, McCluskey J, Munitz TI, Germain RN, Margulies DH, Singer A. T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4. Nature. 317: 425-7. PMID 3930971 DOI: 10.1038/317425A0  0.452
1985 Germain RN, Ashwell JD, Lechler RI, Margulies DH, Nickerson KM, Suzuki G, Tou JY. "Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proceedings of the National Academy of Sciences of the United States of America. 82: 2940-4. PMID 3921966 DOI: 10.1073/Pnas.82.9.2940  0.338
1985 Hedrick SM, Germain RN, Bevan MJ, Dorf M, Engel I, Fink P, Gascoigne N, Heber-Katz E, Kapp J, Kaufmann Y. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proceedings of the National Academy of Sciences of the United States of America. 82: 531-5. PMID 2578667 DOI: 10.1073/Pnas.82.2.531  0.333
1985 McCluskey J, Germain RN, Margulies DH. Cell surface expression of an in vitro recombinant class II/class I major histocompatibility complex gene product. Cell. 40: 247-57. PMID 2578320 DOI: 10.1016/0092-8674(85)90139-4  0.352
1984 Germain RN, Norcross MA, Margulies DH. Functional expression of a transfected murine class II MHC gene. Nature. 306: 190-4. PMID 6606131 DOI: 10.1038/306190A0  0.423
1984 Norcross MA, Bentley DM, Margulies DH, Germain RN. Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. Journal of Experimental Medicine. 160: 1316-1337. PMID 6436430 DOI: 10.1084/Jem.160.5.1316  0.465
1984 Samelson LE, Germain RN, Schwartz RH. Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proceedings of the National Academy of Sciences of the United States of America. 80: 6972-6. PMID 6316339 DOI: 10.1073/Pnas.80.22.6972  0.422
1983 Weinberger O, Germain RN, Burakoff SJ. Responses to the H-2Kba mutant involve recognition of syngeneic Ia molecules. Nature. 302: 429-31. PMID 6220226 DOI: 10.1038/302429A0  0.654
1981 Letvin NL, Benacerraf B, Germain RN. B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 5113-7. PMID 6975477 DOI: 10.1073/Pnas.78.8.5113  0.682
1981 Whitaker RB, Nepom JT, Sy MS, Takaoki M, Gramm CF, Fox I, Germain RN, Nelles MJ, Greene MI, Benacerraf B. Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate. Proceedings of the National Academy of Sciences of the United States of America. 78: 6441-5. PMID 6458813 DOI: 10.1073/Pnas.78.10.6441  0.567
1981 Sy MS, Nisonoff A, Germain RN, Benacerraf B, Greene MI. Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target. The Journal of Experimental Medicine. 153: 1415-25. PMID 6454748 DOI: 10.1084/Jem.153.6.1415  0.602
1981 Picus J, Germain RN, Fox IJ, Greene MI, Benacerraf B, Letvin NL. Immunologic effects of whole-body ultraviolet (uv) irradiation. III Defective splenic adherent cell function in alloantigen-stimulated T-cell proliferation. Cellular Immunology. 63: 300-7. PMID 6168395 DOI: 10.1016/0008-8749(81)90009-5  0.638
1981 Dietz MH, Sy MS, Benacerraf B, Nisonoff A, Greene MI, Germain RN. Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells. The Journal of Experimental Medicine. 153: 450-63. PMID 6165799 DOI: 10.1084/Jem.153.2.450  0.569
1981 Germain RN. Complementation of H-2 linked genetic defects in the production and function of antigen specific suppressor factor: implications for suppressor cell activation. Molecular Immunology. 17: 851-6. PMID 6163969 DOI: 10.1016/0161-5890(80)90033-4  0.412
1980 Letvin NL, Greene MI, Benacerraf B, Germain RN. Immunologic effects of whole-body ultraviolet irradiation: selective defect in splenic adherent cell function in vitro. Proceedings of the National Academy of Sciences of the United States of America. 77: 2881-5. PMID 6967214 DOI: 10.1073/Pnas.77.5.2881  0.611
1980 Germain RN, Benacerraf B. Helper and suppressor T cell factors. Springer Seminars in Immunopathology. 3: 93-127. PMID 6792727 DOI: 10.1007/BF00199927  0.49
1980 Germain RN, Waltenbaugh C, Benacerraf B. Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor. The Journal of Experimental Medicine. 151: 1245-59. PMID 6445400 DOI: 10.1084/Jem.151.5.1245  0.541
1980 Sy MS, Dietz MH, Germain RN, Benacerraf B, Greene MI. Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors. The Journal of Experimental Medicine. 151: 1183-95. PMID 6445398 DOI: 10.1084/Jem.151.5.1183  0.559
1980 Zubler RH, Benacerraf B, Germain RN. Feedback suppression of the immune response in vitro. II. IgVH-restricted antibody-dependent suppression. The Journal of Experimental Medicine. 151: 681-94. PMID 6444664 DOI: 10.1084/Jem.151.3.681  0.561
1980 Zubler RH, Cantor H, Benacerraf B, Germain RN. Feedback suppression of the immune response in vitro. I. Activity of antigen-stimulated B cells. The Journal of Experimental Medicine. 151: 667-80. PMID 6444663 DOI: 10.1084/Jem.151.3.667  0.594
1980 Weinberger JZ, Germain RN, Benacerraf B, Dorf ME. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway. The Journal of Experimental Medicine. 152: 161-9. PMID 6156980 DOI: 10.1084/Jem.152.1.161  0.551
1979 Ju ST, Pierres M, Waltenbaugh C, Germain RN, Benacerraf B, Dorf ME. Idiotypic analysis of monoclonal antibodies to poly(Glu60Ala30Tyr10). Proceedings of the National Academy of Sciences of the United States of America. 76: 2942-6. PMID 288079 DOI: 10.1073/Pnas.76.6.2942  0.413
1979 Germain RN, Ju ST, Kipps TJ, Benacerraf B, Dorf ME. Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10. The Journal of Experimental Medicine. 149: 613-22. PMID 107261 DOI: 10.1084/Jem.149.3.613  0.549
1979 Weinberger JZ, Germain RN, Ju ST, Greene MI, Benacerraf B, Dorf ME. Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. The Journal of Experimental Medicine. 150: 761-76. PMID 92517 DOI: 10.1084/Jem.150.4.761  0.555
1979 Pierres M, Ju ST, Waltenbaugh C, Dorf ME, Benacerraf B, Germain RN. Fine specificity of antibodies to poly(Glu60Ala30Tyr10) produced by hybrid cell lines. Proceedings of the National Academy of Sciences of the United States of America. 76: 2425-9. PMID 88055 DOI: 10.1073/Pnas.76.5.2425  0.46
1978 Germain RN, Benacerraf B. The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine. The Journal of Experimental Medicine. 148: 1324-37. PMID 102725 DOI: 10.1084/Jem.148.5.1324  0.505
1978 Pierres M, Germain RN, Dorf ME, Benacerraf B. In vivo effects of anti-Ia alloantisera. I. Elimination of specific suppression by in vivo administration of antisera specific for I-J controlled determinants. The Journal of Experimental Medicine. 147: 656-66. PMID 75939 DOI: 10.1084/Jem.147.3.656  0.485
1978 Germain RN, Thèze J, Kapp JA, Benacerraf B. Antigen-specific T-cell-mediated suppression. I. Induction of L-glutamic acid60-L-alanine30-L-tyrosine10 specific suppressor T cells in vitro requires both antigen-specific T-cell-suppressor factor and antigen. The Journal of Experimental Medicine. 147: 123-36. PMID 75231 DOI: 10.1084/Jem.147.1.123  0.572
1978 Benacerraf B, Germain RN. The immune response genes of the major histocompatibility complex. Immunological Reviews. 38: 70-119. PMID 75166 DOI: 10.1111/J.1600-065X.1978.Tb00385.X  0.469
1977 Pierce CW, Germain RN, Kapp JA, Benacerraf B. Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages. The Journal of Experimental Medicine. 146: 1827-32. PMID 411879 DOI: 10.1084/JEM.146.6.1827  0.423
1977 Pierres M, Germain RN, Dorf ME, Benacerraf B. Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex. Proceedings of the National Academy of Sciences of the United States of America. 74: 3975-9. PMID 410029 DOI: 10.1073/Pnas.74.9.3975  0.483
1977 Thèze J, Waltenbaugh C, Germain RN, Benacerraf B. Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyosine50. IV. In vitro activity and immunochemical properties. European Journal of Immunology. 7: 705-10. PMID 73465 DOI: 10.1002/Eji.1830071011  0.454
1976 Burakoff SJ, Germain RN, Benacerraf B. Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells. The Journal of Experimental Medicine. 144: 1609-20. PMID 1087327 DOI: 10.1084/Jem.144.6.1609  0.653
1976 Burakoff SJ, Germain RN, Dorf ME, Benacerrah B. Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex. Proceedings of the National Academy of Sciences of the United States of America. 73: 625-9. PMID 1082140 DOI: 10.1073/Pnas.73.2.625  0.599
1975 Germain RN, Dorf ME, Benacerraf B. Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor. The Journal of Experimental Medicine. 142: 1023-8. PMID 809532 DOI: 10.1084/Jem.142.4.1023  0.545
Low-probability matches (unlikely to be authored by this person)
2019 Gottschalk RA, Dorrington MG, Dutta B, Krauss KS, Martins AJ, Uderhardt S, Chan W, Tsang JS, Torabi-Parizi P, Fraser ID, Germain RN. Author response: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses Elife. DOI: 10.7554/Elife.46836.025  0.298
2003 Scheinecker C, McHugh R, Shevach E, Germain R. Dendritic cells present a tissue-specific autoantigen under steady state and autoimmune conditions in the draining lymph node Arthritis Research & Therapy. 5: 103-103. DOI: 10.1186/Ar904  0.298
2023 Simeonov DR, Park K, Cortez JT, Young A, Li Z, Nguyen V, Umhoefer J, Indart AC, Woo JM, Anderson MS, Tsang JS, Germain RN, Wong HS, Marson A. Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk. Biorxiv : the Preprint Server For Biology. PMID 37503101 DOI: 10.1101/2023.06.17.545426  0.297
2022 Hu Y, Hudson WH, Kissick HT, Medina CB, Baptista AP, Ma C, Liao W, Germain RN, Turley SJ, Zhang N, Ahmed R. TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection. The Journal of Experimental Medicine. 219. PMID 35980386 DOI: 10.1084/jem.20211574  0.297
1987 Pardoll DM, Fowlkes BJ, Lechler RI, Germain RN, Schwartz RH. Early genetic events in T cell development analyzed by in situ hybridization Journal of Experimental Medicine. 165: 1624-1638. PMID 2884272 DOI: 10.1084/Jem.165.6.1624  0.295
2012 Angermann BR, Klauschen F, Garcia AD, Prustel T, Zhang F, Germain RN, Meier-Schellersheim M. Computational modeling of cellular signaling processes embedded into dynamic spatial contexts. Nature Methods. 9: 283-9. PMID 22286385 DOI: 10.1038/Nmeth.1861  0.295
1994 Romagnoli P, Germain RN. The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. The Journal of Experimental Medicine. 180: 1107-13. PMID 8064228 DOI: 10.1084/Jem.180.3.1107  0.294
2005 Germain RN. Imaging dynamic interactions in immune responses. Seminars in Immunology. 17: 385-6. PMID 16275126 DOI: 10.1016/J.Smim.2005.10.001  0.294
2017 Veres TZ, Kopcsányi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M. Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy. Scientific Reports. 7: 694. PMID 28386104 DOI: 10.1038/S41598-017-00769-6  0.293
2006 Chieppa M, Huang A, Rescigno M, Germain RN. Intravital 2-Photon Microscopy of Dendritic Cell Extension Sampling Pathogen Bacteria Into the Small Bowel Lumen Inflammatory Bowel Diseases. 12: S20. DOI: 10.1097/00054725-200604002-00042  0.293
2018 Germain RN. Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines? What Really Constitutes the Study of "Systems Biology" and How Might Such an Approach Facilitate Vaccine Design. Cold Spring Harbor Perspectives in Biology. 10. PMID 29038120 DOI: 10.1101/Cshperspect.A033308  0.292
1993 Romagnoli P, Layet C, Yewdell J, Bakke O, Germain RN. Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments. The Journal of Experimental Medicine. 177: 583-96. PMID 8436902 DOI: 10.1084/Jem.177.3.583  0.29
1994 Bonnerot C, Marks MS, Cosson P, Robertson EJ, Bikoff EK, Germain RN, Bonifacino JS. Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain. The Embo Journal. 13: 934-44. PMID 8112308 DOI: 10.1002/J.1460-2075.1994.Tb06338.X  0.289
2001 Castellino F, Han R, Germain RN. The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP-independent manner. European Journal of Immunology. 31: 841-50. PMID 11241289 DOI: 10.1002/1521-4141(200103)31:3<841::Aid-Immu841>3.0.Co;2-D  0.286
2013 Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell. 153: 348-61. PMID 23582325 DOI: 10.1016/J.Cell.2013.02.054  0.285
2022 Xu Q, Milanez-Almeida P, Martins AJ, Radtke AJ, Hoehn KB, Oguz C, Chen J, Liu C, Tang J, Grubbs G, Stein S, Ramelli S, Kabat J, Behzadpour H, Karkanitsa M, ... ... Germain RN, et al. Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children. Nature Immunology. PMID 36536106 DOI: 10.1038/s41590-022-01367-z  0.284
1986 Germain RN, Bentley DM, Quill H. Influence of allelic polymorphism on the assembly and surface expression of class II MHC (Ia) molecules. Cell. 43: 233-42. PMID 3935317 DOI: 10.1016/0092-8674(85)90028-5  0.284
1990 Takahashi H, Takeshita T, Morein B, Putney S, Germain RN, Berzofsky JA. Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature. 344: 873-5. PMID 2184369 DOI: 10.1038/344873A0  0.282
2012 Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 492: 123-7. PMID 23143333 DOI: 10.1038/Nature11588  0.28
1983 Auffray C, Ben-Nun A, Roux-Dosseto M, Germain R, Seidman J, Strominger J. Polymorphism and complexity of the human DC and murine I-A alpha chain genes. The Embo Journal. 2: 121-124. DOI: 10.1002/J.1460-2075.1983.Tb01392.X  0.279
1983 Choi E, McIntyre K, Germain RN, Seidman JG. Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (New York, N.Y.). 221: 283-6. PMID 6407114 DOI: 10.1126/Science.6407114  0.278
2010 Germain RN. Vaccines and the future of human immunology. Immunity. 33: 441-50. PMID 21029956 DOI: 10.1016/J.Immuni.2010.09.014  0.278
2011 Germain RN, Meier-Schellersheim M, Angermann B, Klauschen F, Zhang F, Brandes-Kuchen M, Garcia A, Prustel T, Fraser I, Li N, Deng L, Sun J, Benet Z, Nita-Lazar A, Tsang J. PL2-1. Bottom-up and Top-Down Systems Biology Approaches to Understanding Immunity Cytokine. 56: 50. DOI: 10.1016/J.Cyto.2011.07.295  0.276
1996 Romagnoli P, Germain RN. Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexes. The Journal of Experimental Medicine. 182: 2027-36. PMID 7500048 DOI: 10.1084/Jem.182.6.2027  0.275
2007 Durum SK, Warming S, Lawrence SM, Ishii M, Abshari M, Feigenbaum L, Washington AV, Warner AC, Sims DJ, Qing Li W, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, ... ... Germain RN, et al. 33 Visualization and Identification of IL-7 Producing Cells Cytokine. 39: 9-10. DOI: 10.1016/J.Cyto.2007.07.038  0.273
2011 Germain RN, Schwartzberg PL. The human condition: an immunological perspective. Nature Immunology. 12: 369-72. PMID 21502986 DOI: 10.1038/Ni0511-369  0.272
2013 Brandes M, Klauschen F, Kuchen S, Germain RN. A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell. 154: 197-212. PMID 23827683 DOI: 10.1016/J.Cell.2013.06.013  0.27
2019 Freeman SA, Uderhardt S, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren D, Grinstein S. Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science (New York, N.Y.). PMID 31806695 DOI: 10.1126/Science.Aaw9544  0.27
2011 Germain RN, Paul WE. Baruj Benacerraf (1920-2011). Nature. 477: 34. PMID 21886149 DOI: 10.1038/477034A  0.266
2015 Germain RN. William E. Paul, M.D. (1936-2015), President, The American Association of Immunologists, 1986-1987. Journal of Immunology (Baltimore, Md. : 1950). 195: 5519-21. PMID 26637660 DOI: 10.4049/Jimmunol.1590025  0.265
2011 Germain RN, Meier-Schellersheim M, Nita-Lazar A, Fraser ID. Systems biology in immunology: a computational modeling perspective. Annual Review of Immunology. 29: 527-85. PMID 21219182 DOI: 10.1146/Annurev-Immunol-030409-101317  0.264
2023 Hor JL, Germain RN. Spatiotemporal and cell-state control of antigen presentation during tolerance and immunity. Current Opinion in Immunology. 84: 102357. PMID 37331219 DOI: 10.1016/j.coi.2023.102357  0.263
1981 Germain RN. Regulatory T Lymphocytes. Benvenuto Pernis , Henry J. Vogel The Quarterly Review of Biology. 56: 239-240. DOI: 10.1086/412305  0.263
1995 Bikoff EK, Germain RN, Robertson EJ. Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. Immunity. 2: 301-10. PMID 7697546 DOI: 10.1016/1074-7613(95)90054-3  0.261
2009 Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature. 458: 524-8. PMID 19204730 DOI: 10.1038/Nature07713  0.258
2015 Kong L, Tang J, Little JP, Yu Y, Lämmermann T, Lin CP, Germain RN, Cui M. Continuous volumetric imaging via an optical phase-locked ultrasound lens. Nature Methods. 12: 759-62. PMID 26167641 DOI: 10.1038/Nmeth.3476  0.256
2006 Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement The Journal of Cell Biology. 175: i15-i15. DOI: 10.1083/JCB1756OIA15  0.255
1987 Sant AJ, Braunstein NS, Germain RN. Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression. Proceedings of the National Academy of Sciences of the United States of America. 84: 8065-9. PMID 3120183 DOI: 10.1073/Pnas.84.22.8065  0.255
1992 Ruberti G, Sellins KS, Hill CM, Germain RN, Fathman CG, Livingstone A. Presentation of antigen by mixed isotype class II molecules in normal H-2d mice. The Journal of Experimental Medicine. 175: 157-62. PMID 1730914 DOI: 10.1084/Jem.175.1.157  0.253
2022 Manthiram K, Xu Q, Milanez-Almeida P, Martins A, Radtke A, Hoehn K, Chen J, Liu C, Tang J, Grubbs G, Stein S, Ramelli S, Kabat J, Behzadpour H, Karkanitsa M, ... ... Germain R, et al. Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children. Research Square. PMID 35350206 DOI: 10.21203/rs.3.rs-1276578/v1  0.252
1986 Malek TR, Ashwell JD, Germain RN, Shevach EM, Miller J. The murine interleukin-2 receptor: biochemical structure and regulation of expression. Immunological Reviews. 92: 81-101. PMID 3091485 DOI: 10.1111/J.1600-065X.1986.Tb01495.X  0.25
2020 Gola A, Dorrington MG, Speranza E, Sala C, Shih RM, Radtke AJ, Wong HS, Baptista AP, Hernandez JM, Castellani G, Fraser IDC, Germain RN. Commensal-driven immune zonation of the liver promotes host defence. Nature. PMID 33239787 DOI: 10.1038/s41586-020-2977-2  0.25
2021 Chan W, Gottschalk RA, Yao Y, Pomerantz JL, Germain RN. Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools. Immunohorizons. 5: 117-132. PMID 33622708 DOI: 10.4049/immunohorizons.2000082  0.248
2008 Peters NC, Egen JG, Secundino N, Debrabant A, Kimblin N, Kamhawi S, Lawyer P, Fay MP, Germain RN, Sacks D. In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science (New York, N.Y.). 321: 970-4. PMID 18703742 DOI: 10.1126/Science.1159194  0.248
2018 Germain RN, Greenbaum BD, Hoffmann A, Miller-Jensen K, Mora T, Walczak AM, Segal E, Vogl T, Klompus S, Peled-Liviatan S, Weinberger A, Smale ST, Tsang JS. What Can Immunologists Learn from Systems Approaches Trends in Immunology. 39: 163-166. PMID 29477635 DOI: 10.1016/J.It.2018.01.002  0.247
2021 Germain RN, Radtke AJ, Thakur N, Schrom EC, Hor JL, Ichise H, Arroyo-Mejias AJ, Chu CJ, Grant S. Understanding immunity in a tissue-centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction. Immunological Reviews. PMID 34918351 DOI: 10.1111/imr.13052  0.246
2018 Yao L, Gregg L, Germain RN, Soloski MJ. Lymphatic Voyage: Communicating 4D Immune Cell Dynamics and Lymph Node Architecture using WebGL-based Animation and Interactivity Journal of Biocommunication. 42. DOI: 10.5210/jbc.v42i1.9185  0.241
2021 Hor JL, Germain RN. Intravital and high-content multiplex imaging of the immune system. Trends in Cell Biology. PMID 34920936 DOI: 10.1016/j.tcb.2021.11.007  0.237
2021 Dong R, Aksel T, Chan W, Germain RN, Vale RD, Douglas SM. DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34588308 DOI: 10.1073/pnas.2109057118  0.237
2020 Kagan J, Moritz RL, Mazurchuck R, Lee JH, Kharchenko PV, Rozenblatt-Rosen O, Ruppin E, Edfors F, Ginty F, Goltsev Y, Wells JA, LaCava J, Riesterer JL, Germain RN, Shi T, et al. NCI Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. Journal of Proteome Research. PMID 32163288 DOI: 10.1021/Acs.Jproteome.0C00021  0.236
2010 Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. The Journal of Experimental Medicine. 207: 2793-8. PMID 21135136 DOI: 10.1084/Jem.20101474  0.235
2002 Germain RN. Two hats too many Current Biology. 12: R376. DOI: 10.1016/S0960-9822(02)00875-8  0.233
2022 Speranza E, Purushotham JN, Port JR, Schwarz B, Flagg M, Williamson BN, Feldmann F, Singh M, Pérez-Pérez L, Sturdevant GL, Roberts LM, Carmody A, Schulz JE, van Doremalen N, Okumura A, ... ... Germain RN, et al. Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques. Life Science Alliance. 5. PMID 35039442 DOI: 10.26508/lsa.202101314  0.228
2012 Tang J, Germain RN, Cui M. Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique. Proceedings of the National Academy of Sciences of the United States of America. 109: 8434-9. PMID 22586078 DOI: 10.1073/Pnas.1119590109  0.228
2016 Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Beuhler E, Fraser ID. An interactive web-based application for Comprehensive Analysis of RNAi-screen Data. Nature Communications. 7: 10578. PMID 26902267 DOI: 10.1038/Ncomms10578  0.22
1990 Germain RN. Immunology. Making a molecular match. Nature. 344: 19-22. PMID 2406610 DOI: 10.1038/344019A0  0.219
2015 Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN. Mitochondria play a central role in NLRP3 inflammasome activation Mitochondrion. 24: S15-S16. DOI: 10.1016/J.Mito.2015.07.049  0.217
2015 Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ. William E. Paul, MD (1936-2015). Trends in Immunology. 36: 751-3. PMID 27064162 DOI: 10.1016/J.It.2015.10.001  0.213
1990 Solomon SD, Jarcho JA, McKenna W, Geisterfer-Lowrance A, Germain R, Salerni R, Seidman JG, Seidman CE. Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease. The Journal of Clinical Investigation. 86: 993-9. PMID 1975599 DOI: 10.1172/Jci114802  0.21
2021 Walters N, Zhang J, Rima XY, Nguyen LTH, Germain RN, Lämmermann T, Reátegui E. Analyzing Inter-Leukocyte Communication and Migration : Neutrophils Play an Essential Role in Monocyte Activation During Swarming. Frontiers in Immunology. 12: 671546. PMID 34054848 DOI: 10.3389/fimmu.2021.671546  0.209
2020 Milanez-Almeida P, Martins AJ, Germain RN, Tsang JS. Cancer prognosis with shallow tumor RNA sequencing. Nature Medicine. 26: 188-192. PMID 32042193 DOI: 10.1038/S41591-019-0729-3  0.207
2011 Bumb A, Regino CA, Egen JG, Bernardo M, Dobson PJ, Germain RN, Choyke PL, Brechbiel MW. Trafficking of a dual-modality magnetic resonance and fluorescence imaging superparamagnetic iron oxide-based nanoprobe to lymph nodes. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 13: 1163-72. PMID 21080233 DOI: 10.1007/S11307-010-0424-8  0.206
2020 Radtke AJ, Shaffer AL, Pittaluga S, Bagaev A, Thakur N, Davies-Hill T, Plotnikova O, Galkin I, Postovalova E, Svekolkin V, Isaev S, Lozinsky Y, Meerson M, Varlamova A, Ovcharov P, ... ... Germain RN, et al. Integration and Iteration: Using Advanced, High-Content Imaging and Single-Cell Gene Expression Analysis to Uncover Unique Aspects of Follicular Lymphoma Biology Blood. 136: 9-10. DOI: 10.1182/blood-2020-142633  0.206
2018 Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell C, Scott AJ, Ernst RK. intradermal delivery of bacteria using microneedle arrays. Infection and Immunity. PMID 29986891 DOI: 10.1128/Iai.00406-18  0.2
2022 Rahman SMT, Aqdas M, Martin EW, Tomassoni Ardori F, Songkiatisak P, Oh KS, Uderhardt S, Yun S, Claybourne QC, McDevitt RA, Greco V, Germain RN, Tessarollo L, Sung MH. Double knockin mice show NF-κB trajectories in immune signaling and aging. Cell Reports. 41: 111682. PMID 36417863 DOI: 10.1016/j.celrep.2022.111682  0.198
2021 Rommereim L, Akhade AS, Germain RN, Fraser IDC, Subramanian N. Lentivirus-mediated Conditional Gene Expression. Bio-Protocol. 11: e4205. PMID 34859120 DOI: 10.21769/BioProtoc.4205  0.197
2016 Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Buehler E, Fraser ID. Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data. Nature Communications. 7: 11214. PMID 26997126 DOI: 10.1038/Ncomms11214  0.195
2015 Germain RN. Healing the NIH-Funded Biomedical Research Enterprise. Cell. 161: 1485-91. PMID 26091028 DOI: 10.1016/J.Cell.2015.05.052  0.192
2022 Manes NP, Calzola JM, Kaplan PR, Fraser IDC, Germain RN, Meier-Schellersheim M, Nita-Lazar A. Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways. Scientific Data. 9: 491. PMID 35961990 DOI: 10.1038/s41597-022-01612-y  0.19
2010 Dustin M, Zanin-Zhorov AZ, Ding Y, Kumari S, Hippen K, Attur M, Abramson S, Blazar B, Lafaille J, Brown M, Germain R, Huang AYC, Qi H, Castellino F, Bajenoff M, et al. Immuno imaging (SY4-3) Chairpersons: Takashi Saito, Susan Pierce International Immunology. 22. DOI: 10.1093/Intimm/Dxq289  0.187
2021 Hickey JW, Neumann EK, Radtke AJ, Camarillo JM, Beuschel RT, Albanese A, McDonough E, Hatler J, Wiblin AE, Fisher J, Croteau J, Small EC, Sood A, Caprioli RM, Angelo RM, ... ... Germain RN, et al. Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. Nature Methods. PMID 34811556 DOI: 10.1038/s41592-021-01316-y  0.178
2015 Germain RN. William E. Paul (1936-2015). Nature. 526: 324. PMID 26469035 DOI: 10.1038/526324A  0.174
2023 Zhao C, Germain RN. Multiplex imaging in immuno-oncology. Journal For Immunotherapy of Cancer. 11. PMID 37899132 DOI: 10.1136/jitc-2023-006923  0.172
2003 Paul WE, Germain RN. Obituary: Charles A. Janeway Jr (1943-2003). Nature. 423: 237. PMID 12748629 DOI: 10.1038/423237A  0.162
2020 Radtke AJ, Kandov E, Lowekamp B, Speranza E, Chu CJ, Gola A, Thakur N, Shih R, Yao L, Yaniv ZR, Beuschel RT, Kabat J, Croteau J, Davis J, Hernandez JM, ... Germain RN, et al. IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues. Proceedings of the National Academy of Sciences of the United States of America. 117: 33455-33465. PMID 33376221 DOI: 10.1073/pnas.2018488117  0.162
1989 Bill J, Ronchese F, Germain RN, Palmer E. The contribution of mutant amino acids to alloantigenicity. The Journal of Experimental Medicine. 170: 739-50. PMID 2769182 DOI: 10.1084/JEM.170.3.739  0.157
2020 Rommereim LM, Akhade AS, Dutta B, Hutcheon C, Lounsbury NW, Rostomily CC, Savan R, Fraser IDC, Germain RN, Subramanian N. A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses. Science Signaling. 13. PMID 33293463 DOI: 10.1126/scisignal.aba3244  0.153
2023 Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, et al. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Systems. 14: 252-257. PMID 37080161 DOI: 10.1016/j.cels.2023.03.002  0.145
1986 Germain RN, Malissen B. Analysis of the expression and function of class-II major histocompatibility complex-encoded molecules by DNA-mediated gene transfer. Annual Review of Immunology. 4: 281-315. PMID 3518745 DOI: 10.1146/ANNUREV.IY.04.040186.001433  0.138
2022 Germain RN. Imaging the immune system redux. Immunological Reviews. 306: 5-7. PMID 35034360 DOI: 10.1111/imr.13063  0.136
2021 Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmüller W, Lämmermann T. Neutrophils self-limit swarming to contain bacterial growth in vivo. Science (New York, N.Y.). 372. PMID 34140358 DOI: 10.1126/science.abe7729  0.133
2015 Subramanian N, Torabi-Parizi P, Gottschalk RA, Germain RN, Dutta B. Network representations of immune system complexity Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 7: 13-38. DOI: 10.1002/wsbm.1288  0.131
2006 Bajénoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging Journal of Cell Biology. 172: i13-i13. DOI: 10.1083/JCB1726OIA13  0.131
2023 Schrom EC, McCaffrey EF, Radtke AJ, Speranza E, Arakkal L, Thakur N, Grant S, Germain RN. Spatial Patterning Analysis of Cellular Ensembles (SPACE) enables statistically robust discovery of complex spatial organization at the cell and tissue level. Biorxiv : the Preprint Server For Biology. PMID 38168288 DOI: 10.1101/2023.12.08.570837  0.12
2022 Gola A, Dorrington MG, Speranza E, Sala C, Shih RM, Radtke AJ, Wong HS, Baptista AP, Hernandez JM, Castellani G, Fraser IDC, Germain RN. Author Correction: Commensal-driven immune zonation of the liver promotes host defence. Nature. 611: E7. PMID 36280745 DOI: 10.1038/s41586-022-05462-x  0.119
2023 Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Casals AM, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, ... ... Germain RN, et al. Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging. Nature Methods. PMID 37468619 DOI: 10.1038/s41592-023-01846-7  0.107
2021 Gola A, Dorrington MG, Speranza E, Sala C, Shih RM, Radtke AJ, Wong HS, Baptista AP, Hernandez JM, Castellani G, Fraser IDC, Germain RN. Author Correction: Commensal-driven immune zonation of the liver promotes host defence. Nature. PMID 34373651 DOI: 10.1038/s41586-021-03346-0  0.106
2017 Shields AF, Jacobs P, Sznol M, Graham MM, Germain R, Lum L, Jaffee E, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung D, Wu AM, Sharon E, Shankar LK. Immune Modulation Therapy and Imaging: Workshop Report. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28818991 DOI: 10.2967/Jnumed.117.195610  0.098
1986 Braunstein N, Germain R. The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription. The Embo Journal. 5: 2469-2476. DOI: 10.1002/j.1460-2075.1986.tb04523.x  0.095
2022 Radtke AJ, Chu CJ, Yaniv Z, Yao L, Marr J, Beuschel RT, Ichise H, Gola A, Kabat J, Lowekamp B, Speranza E, Croteau J, Thakur N, Jonigk D, Davis JL, ... ... Germain RN, et al. IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues. Nature Protocols. PMID 35022622 DOI: 10.1038/s41596-021-00644-9  0.092
2018 Khurana S, Coyle EM, Manischewitz J, King LR, Gao J, Germain RN, Schwartzberg PL, Tsang JS, Golding H. AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization. Npj Vaccines. 3: 40. PMID 30302282 DOI: 10.1038/s41541-018-0076-2  0.088
2022 Wong-Rolle A, Dong Q, Zhu Y, Divakar P, Hor JL, Kedei N, Wong M, Tillo D, Conner EA, Rajan A, Schrump DS, Jin C, Germain RN, Zhao C. Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature. Journal For Immunotherapy of Cancer. 10. PMID 35793869 DOI: 10.1136/jitc-2022-004698  0.069
2022 Kuchina A, Yang J, Aldridge B, Janes KA, Subramanian N, Krogan NJ, Bouhaddou M, Einav S, Papin J, Germain RN. How can systems approaches help us understand and treat infectious disease? Cell Systems. 13: 945-949. PMID 36549272 DOI: 10.1016/j.cels.2022.11.009  0.037
2016 Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ. William E. Paul, MD (1936-2015)(black small square)(black small square) Trends in Immunology. DOI: 10.1016/j.it.2015.10.001  0.025
2015 Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ. William E. Paul, M.D. (1936–2015). Immunity. 43: 617-9. PMID 26788561  0.019
2005 Germain RN. Seeing double. Current Biology : Cb. 3: 586-9. PMID 15335672 DOI: 10.1016/0960-9822(93)90004-8  0.01
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