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Sachdev Sidhu - Publications

Affiliations: 
Molecular Genetics University of Toronto, Toronto, ON, Canada 
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47/322 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, ... ... Sidhu SS, et al. Structural surfaceomics reveals an AML-specific conformation of integrin β as a CAR T cellular therapy target. Nature Cancer. PMID 37904046 DOI: 10.1038/s43018-023-00652-6  0.309
2023 Giang KA, Sidhu SS, Nilvebrant J. Construction of Synthetic Antibody Phage Display Libraries. Methods in Molecular Biology (Clifton, N.J.). 2702: 59-75. PMID 37679615 DOI: 10.1007/978-1-0716-3381-6_4  0.303
2021 Philpott DN, Gomis S, Wang H, Atwal R, Kelil A, Sack T, Morningstar B, Burnie C, Sargent EH, Angers S, Sidhu S, Kelley SO. Rapid On-Cell Selection of High-Performance Human Antibodies. Acs Central Science. 8: 102-109. PMID 35106377 DOI: 10.1021/acscentsci.1c01205  0.313
2021 Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. A T cell redirection platform for co-targeting dual antigens on solid tumors. Mabs. 13: 1933690. PMID 34190031 DOI: 10.1080/19420862.2021.1933690  0.314
2021 Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS. Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody That Targets Two Distinct Epitopes on αv Integrins. Journal of Molecular Biology. 167090. PMID 34090922 DOI: 10.1016/j.jmb.2021.167090  0.323
2020 Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, ... ... Sidhu S, et al. Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. Cell Host & Microbe. PMID 32735849 DOI: 10.1016/J.Chom.2020.06.021  0.36
2020 Moffat J, Zhang X, Lawson K, Banerjee S, Wang X, Adams J, Pan J, Ailles L, Finelli A, Sidhu S. Abstract B49: Development and characterization of a novel CA9 targeting dual-antibody T-cell engager for renal cell carcinoma Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-B49  0.379
2019 Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, ... Sidhu SS, et al. Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30894493 DOI: 10.1073/Pnas.1817246116  0.321
2019 Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J. A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Scientific Reports. 9: 842. PMID 30696911 DOI: 10.1038/S41598-018-37462-1  0.331
2019 Vora P, Venugopal C, Chokshi C, Qazi M, Tatari N, Brown K, Yelle N, Adams J, Tieu D, Seyfrid M, Singh M, Savage N, Subapanditha M, Bakhshinyan D, Kuhlmann L, ... ... Sidhu S, et al. Abstract 570: A glioblastoma translational pipeline: discovery of novel tumor antigens that drive GBM recurrence Cancer Research. 79: 570-570. DOI: 10.1158/1538-7445.Am2019-570  0.344
2018 Liu H, Huang H, Voss C, Kaneko T, Qin W, Sidhu S, Shun-Cheng Li SS. Surface loops in a single SH2 domain are capable of encoding the spectrum of specificity of the SH2 family. Molecular & Cellular Proteomics : McP. PMID 30482845 DOI: 10.1074/Mcp.Ra118.001123  0.322
2018 Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu AX, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, ... ... Sidhu S, et al. Co-targeting ephrin receptor tyrosine kinases A2 and A3 in cancer stem cells reduces growth of recurrent glioblastoma. Cancer Research. PMID 29945963 DOI: 10.1158/0008-5472.Can-18-0267  0.353
2018 Nelson B, Adams J, Kuglstatter A, Li Z, Harris SF, Liu Y, Bohini S, Ma H, Klumpp K, Gao J, Sidhu SS. Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies. Journal of Molecular Biology. PMID 29778602 DOI: 10.1016/j.jmb.2018.05.018  0.301
2018 Vora P, Adams J, Singh M, Venugopal C, Tatari N, Chokshi C, Qazi M, Salim S, Mahendram S, Bakhshinyan D, London M, Savage N, Subapanditha M, McFarlane N, Pan J, ... ... Sidhu S, et al. Abstract 1763: BiTEs vs CAR-Ts: Preclinical targeting of CD133+ brain tumor initiating cells using immunotherapy-based treatment strategies Cancer Research. 78: 1763-1763. DOI: 10.1158/1538-7445.Am2018-1763  0.403
2017 Apel AR, Hoban K, Chuartzman S, Tonikian R, Sidhu S, Schuldiner M, Wendland B, Prosser D. Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif. Molecular Biology of the Cell. PMID 28701344 DOI: 10.1091/Mbc.E15-10-0731  0.365
2017 Liu H, Saxena A, Sidhu SS, Wu D. Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds. Frontiers in Immunology. 8: 38. PMID 28184223 DOI: 10.3389/fimmu.2017.00038  0.34
2017 Vora P, Chokshi C, Qazi M, Singh M, Venugopal C, Mahendram S, Adams J, Bakhshinyan D, London M, Singh J, Subapanditha M, McFarlane N, Pan J, Bramson J, Sidhu S, et al. Abstract 3758: The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of glioblastoma Cancer Research. 77: 3758-3758. DOI: 10.1158/1538-7445.Am2017-3758  0.393
2017 Qazi M, Vora P, Chokshi C, Venugopal C, London M, Hu A, Subapandtiha M, Singh M, Adams J, Moffat J, Sidhu S, Singh SK. Abstract 3639: Therapeutic targeting of tumorigenic EphA2+/EphA3+ brain tumor initiating cells with bi-specific antibody in human glioblastoma Cancer Research. 77: 3639-3639. DOI: 10.1158/1538-7445.Am2017-3639  0.388
2017 Qazi M, Vora P, Venugopal C, Gorelik M, Singh M, Hu A, Subapanditha M, Chokshi C, Savage N, Yelle N, Adams J, Moffat J, Sidhu S, Singh S. IMMU-03. THERAPEUTIC TARGETING OF TUMORIGENIC
EphA2+/EphA3+ BRAIN TUMOR INITIATING CELLS WITH BISPECIFIC ANTIBODY IN HUMAN GLIOBLASTOMA Neuro-Oncology. 19: vi113-vi113. DOI: 10.1093/Neuonc/Nox168.462  0.38
2017 Singh M, Venugopal C, Vora P, Adams J, Pan J, Chokshi C, Murty N, Sidhu S, Moffat J, Singh S. CMET-35. PRELIMINARY SCREENING OF A NOVEL EpCAM BISPECIFIC T-CELL ENGAGER (BiTE) ANTIBODY TO TARGET A BMIC POPULATION IN HUMAN BRAIN METASTASES Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.182  0.369
2016 Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. Journal of Molecular Biology. PMID 27887869 DOI: 10.1016/j.jmb.2016.11.016  0.31
2016 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. PMID 27869803 DOI: 10.1038/Nm.4219  0.426
2016 Vora P, Qazi M, Chokshi C, Venugopal C, London M, Hu A, McFarlane N, Subapanditha M, Singh M, Mahendram S, Adams J, Moffat J, Sidhu S, Singh S. Abstract B092: Therapeutic targeting of tumorigenic EphA2+/EphA3+ brain tumor initiating cells with bi-specific antibody in glioblastoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B092  0.416
2016 Vora P, Chokshi C, Qazi M, Venugopal C, Mahendram S, Singh M, Adams J, Bakhshinyan D, London M, Subapanditha M, McFarlane N, Pan J, Bramson J, Moffat J, Sidhu S, et al. Abstract B079: The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of recurrent glioblastoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B079  0.388
2016 Steinhart Z, Hart T, Sidhu S, Moffat J, Angers S. Abstract IA13: Inhibiting the Wnt pathway with selective anti-Frizzled synthetic antibodies Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Ia13  0.419
2016 Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, Macleod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Driks P, Sidhu S, Roth FP, Rissland OS, Durocher D, et al. Abstract PR03: High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with CRISPR-Cas9 screens Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Pr03  0.355
2016 Tomic J, McLaughlin M, Geyer R, Sidhu S, Moffat J. Abstract 2972: Development and characterization of synthetic antibodies with a human framework that directly link metabolism to immune system in cancer cells Cancer Research. 76: 2972-2972. DOI: 10.1158/1538-7445.Am2016-2972  0.363
2016 Vora P, Venugopal C, Mahendram S, Chokshi C, Qazi M, Subapanditha M, Singh M, Bakhshinyan D, Bezverbnaya K, Adams J, McFarlane N, Sidhu S, Moffat J, Bramson J, Singh S. Abstract 2300: Human CD133-specific chimeric antigen receptor (CAR) modified T cells target patient-derived glioblastoma brain tumors Cancer Research. 76: 2300-2300. DOI: 10.1158/1538-7445.Am2016-2300  0.372
2016 Vora P, Venugopal C, Adams J, Pan J, Chokshi C, Qazi M, Subapanditha M, Singh M, Bakhshinyan D, Bezverbnaya K, McFarlane N, Bramson J, Sidhu S, Moffat J, Singh S. Abstract 1481: Preclinical validation of a novel CD133/CD3 bispecific T-cell engager (BiTE) antibody to target patient-derived glioblastoma cells Cancer Research. 76: 1481-1481. DOI: 10.1158/1538-7445.Am2016-1481  0.394
2016 Vora P, Venugopal C, Choksi C, Qazi M, Adams J, London M, Subapanditha M, Singh M, Bakshinyan D, Sidhu S, Moffat J, Singh S. PS2 - 172 Preclinical Validation of a Novel CD33/CD3 Bispecific T-Cell Engager (BiTE) Antibody to Target Patient-Derived Glioblastoma Cells Canadian Journal of Neurological Sciences. 43. DOI: 10.1017/Cjn.2016.367  0.371
2015 Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, et al. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. PMID 26627737 DOI: 10.1016/J.Cell.2015.11.015  0.344
2015 Huang H, Economopoulos NO, Liu BA, Uetrecht A, Gu J, Jarvik N, Nadeem V, Pawson T, Moffat J, Miersch S, Sidhu SS. Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display. Protein Science : a Publication of the Protein Society. 24: 1890-900. PMID 26332758 DOI: 10.1002/Pro.2799  0.348
2015 Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, ... ... Sidhu S, et al. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Molecular & Cellular Proteomics : McP. PMID 26290498 DOI: 10.1074/Mcp.O115.052209  0.429
2015 Luz D, Chen G, Maranhão AQ, Rocha LB, Sidhu S, Piazza RM. Development and characterization of recombinant antibody fragments that recognize and neutralize in vitro Stx2 toxin from Shiga toxin-producing Escherichia coli. Plos One. 10: e0120481. PMID 25790467 DOI: 10.1371/Journal.Pone.0120481  0.379
2015 Miersch S, Li Z, Hanna R, McLaughlin ME, Hornsby M, Matsuguchi T, Paduch M, Sääf A, Wells J, Koide S, Kossiakoff A, Sidhu SS. Scalable high throughput selection from phage-displayed synthetic antibody libraries. Journal of Visualized Experiments : Jove. 51492. PMID 25651360 DOI: 10.3791/51492  0.301
2015 Griffin C, Miersch S, Marcon E, Banerjee S, Wells J, Hornsby M, Kossiakoff A, Koide S, Paduch M, Sidhu S, Moffat J. Validation of Recombinant Antibodies Against Human Transcription Factors The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.571.13  0.345
2014 Abu-Odeh M, Bar-Mag T, Huang H, Kim T, Salah Z, Abdeen SK, Sudol M, Reichmann D, Sidhu S, Kim PM, Aqeilan RI. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. The Journal of Biological Chemistry. 289: 8865-80. PMID 24550385 DOI: 10.1074/Jbc.M113.506790  0.333
2013 Owen SC, Patel N, Logie J, Pan G, Persson H, Moffat J, Sidhu SS, Shoichet MS. Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 395-404. PMID 23880472 DOI: 10.1016/J.Jconrel.2013.07.011  0.307
2013 Rojas G, Pupo A, Leon K, Avellanet J, Carmenate T, Sidhu S. Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: a versatile platform for fine epitope mapping. Immunobiology. 218: 105-13. PMID 22459271 DOI: 10.1016/J.Imbio.2012.02.009  0.383
2012 Sidhu S. Synthetic Proteins Engineered for the Modulation of Cell Signaling Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2400  0.423
2008 Birtalan S, Zhang Y, Fellouse FA, Shao L, Schaefer G, Sidhu SS. The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies Journal of Molecular Biology. 377: 1518-1528. PMID 18336836 DOI: 10.1016/j.jmb.2008.01.093  0.316
2007 Fellouse FA, Esaki K, Birtalan S, Raptis D, Cancasci VJ, Koide A, Jhurani P, Vasser M, Wiesmann C, Kossiakoff AA, Koide S, Sidhu SS. High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. Journal of Molecular Biology. 373: 924-40. PMID 17825836 DOI: 10.1016/J.Jmb.2007.08.005  0.312
2007 Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D. Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Molecular Systems Biology. 3: 116. PMID 17551511 DOI: 10.1038/Msb4100159  0.32
2006 Li B, Russell SJ, Compaan DM, Totpal K, Marsters SA, Ashkenazi A, Cochran AG, Hymowitz SG, Sidhu SS. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. Journal of Molecular Biology. 361: 522-36. PMID 16859704 DOI: 10.1016/J.Jmb.2006.06.042  0.301
2004 Lee CV, Sidhu SS, Fuh G. Bivalent antibody phage display mimics natural immunoglobulin. Journal of Immunological Methods. 284: 119-32. PMID 14736422 DOI: 10.1016/J.JIM.2003.11.001  0.31
2001 Pelletier J, Sidhu S. Mapping protein-protein interactions with combinatorial biology methods Current Opinion in Biotechnology. 12: 340-347. PMID 11551461 DOI: 10.1016/S0958-1669(00)00225-1  0.305
1998 Baardsnes J, Sidhu S, MacLeod A, Elliott J, Morden D, Watson J, Borgford T. Streptomyces griseus Protease B: Secretion Correlates with the Length of the Propeptide Journal of Bacteriology. 180: 3241-3244. PMID 9620979 DOI: 10.1128/Jb.180.12.3241-3244.1998  0.323
Low-probability matches (unlikely to be authored by this person)
2012 Tonikian R, Sidhu SS. Selecting and purifying autonomous human variable heavy (VH) domains. Methods in Molecular Biology (Clifton, N.J.). 911: 327-53. PMID 22886261 DOI: 10.1007/978-1-61779-968-6_20  0.3
2022 Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey RA, Sidhu SS, Leung DW, Amarasinghe GK. Monoclonal antibodies binding data for SARS-CoV-2 proteins. Data in Brief. 43: 108415. PMID 35789908 DOI: 10.1016/j.dib.2022.108415  0.3
2016 Vora P, Chokshi C, Qazi M, Venugopal C, Mahendram S, Singh M, Adams J, London M, Bakhshinyan D, Subapanditha M, McFarlane N, Pan J, Bramson J, Moffat J, Sidhu S, et al. IMST-53. THE EFFICACY OF CD133 BiTEs AND CAR-T CELLS IN PRECLINICAL MODEL OF RECURRENT GLIOBLASTOMA Neuro-Oncology. 18. DOI: 10.1093/Neuonc/Now212.409  0.298
2014 Liu P, Cai Z, Kang JW, Boyle AJ, Adams J, Lu Y, Ngo Ndjock Mbong G, Sidhu S, Reilly RM, Winnik MA. Intracellular routing in breast cancer cells of streptavidin-conjugated trastuzumab Fab fragments linked to biotinylated doxorubicin-functionalized metal chelating polymers. Biomacromolecules. 15: 715-25. PMID 24506198 DOI: 10.1021/Bm401483A  0.298
2015 Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, ... ... Sidhu SS, et al. Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. Plos One. 10: e0139695. PMID 26437229 DOI: 10.1371/Journal.Pone.0139695  0.298
2018 Pavlovic Z, Adams JJ, Blazer LL, Gakhal AK, Jarvik N, Steinhart Z, Robitaille M, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS. A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties. Mabs. PMID 30183492 DOI: 10.1080/19420862.2018.1515565  0.298
2014 Adams JJ, Nelson B, Sidhu SS. Recombinant genetic libraries and human monoclonal antibodies. Methods in Molecular Biology (Clifton, N.J.). 1060: 149-70. PMID 24037841 DOI: 10.1007/978-1-62703-586-6_9  0.298
2022 Miersch S, Sharma N, Saberianfar R, Chen C, Caccuri F, Zani A, Caruso A, Case JB, Diamond MS, Amarasinghe GK, Novelli G, Sidhu SS. Ultrapotent and broad neutralization of SARS-CoV-2 variants by modular, tetravalent, bi-paratopic antibodies. Cell Reports. 110905. PMID 35617963 DOI: 10.1016/j.celrep.2022.110905  0.297
2018 Nilvebrant J, Sidhu SS. Construction of Synthetic Antibody Phage-Display Libraries. Methods in Molecular Biology (Clifton, N.J.). 1701: 45-60. PMID 29116499 DOI: 10.1007/978-1-4939-7447-4_3  0.296
2016 Na H, Laver JD, Jeon J, Singh F, Ancevicius K, Fan Y, Cao WX, Nie K, Yang Z, Luo H, Wang M, Rissland O, Westwood JT, Kim PM, Smibert CA, ... ... Sidhu SS, et al. A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes. Rna (New York, N.Y.). PMID 26847261 DOI: 10.1261/Rna.055186.115  0.296
2018 Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu S. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. The Journal of Biological Chemistry. PMID 30523157 DOI: 10.1074/Jbc.Ra118.004420  0.296
2013 Hu MC, Shi M, Cho HJ, Zhang J, Pavlenco A, Liu S, Sidhu S, Huang LJ, Moe OW. The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection. Kidney International. 84: 468-81. PMID 23636173 DOI: 10.1038/Ki.2013.149  0.295
2022 Veggiani G, Yates BP, Martyn GD, Manczyk N, Singer AU, Kurinov I, Sicheri F, Sidhu SS. Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. Acs Chemical Biology. 17: 941-956. PMID 35385646 DOI: 10.1021/acschembio.2c00089  0.295
2021 Kelil A, Gallo E, Banerjee S, Adams JJ, Sidhu SS. CellectSeq: In silico discovery of antibodies targeting integral membrane proteins combining in situ selections and next-generation sequencing. Communications Biology. 4: 561. PMID 33980972 DOI: 10.1038/s42003-021-02066-5  0.291
2018 Park M, Xu X, Min W, Sugiman-Marangos SN, Beilhartz GL, Adams JJ, Sidhu SS, Grunebaum E, Melnyk RA. Intracellular delivery of human purine nucleoside phosphorylase by engineered diphtheria toxin rescues function in target cells. Molecular Pharmaceutics. PMID 30212635 DOI: 10.1021/acs.molpharmaceut.8b00735  0.29
2010 Birtalan S, Fisher RD, Sidhu SS. The functional capacity of the natural amino acids for molecular recognition Molecular Biosystems. 6: 1186-1194. PMID 20383388 DOI: 10.1039/b927393j  0.289
2018 Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29476010 DOI: 10.1073/Pnas.1721899115  0.288
2012 Karauzum H, Chen G, Abaandou L, Mahmoudieh M, Boroun AR, Shulenin S, Devi VS, Stavale E, Warfield KL, Zeitlin L, Roy CJ, Sidhu SS, Aman MJ. Synthetic human monoclonal antibodies toward staphylococcal enterotoxin B (SEB) protective against toxic shock syndrome. The Journal of Biological Chemistry. 287: 25203-15. PMID 22645125 DOI: 10.1074/jbc.M112.364075  0.288
2020 Miersch S, Li Z, Saberianfar R, Ustav M, Case JB, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Perez JG, Subramania S, Singh S, Ploder L, Ganaie S, ... ... Sidhu SS, et al. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. Biorxiv : the Preprint Server For Biology. PMID 33398270 DOI: 10.1101/2020.10.31.362848  0.287
2021 Miersch S, Li Z, Saberianfar R, Ustav M, Brett Case J, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Garcia Perez J, Subramania S, Singh S, Ploder L, Ganaie S, ... ... Sidhu SS, et al. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. Journal of Molecular Biology. 167177. PMID 34329642 DOI: 10.1016/j.jmb.2021.167177  0.287
2017 Miersch S, Maruthachalam BV, Geyer CR, Sidhu SS. Structure-Directed and Tailored Diversity Synthetic Antibody Libraries Yield Novel Anti-EGFR Antagonists. Acs Chemical Biology. 12: 1381-1389. PMID 28375604 DOI: 10.1021/acschembio.6b00990  0.286
2012 Miller KR, Koide A, Leung B, Fitzsimmons J, Yoder B, Yuan H, Jay M, Sidhu SS, Koide S, Collins EJ. T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment. Plos One. 7: e43746. PMID 22916301 DOI: 10.1371/Journal.Pone.0043746  0.286
2014 Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nature Chemical Biology. 10: 156-163. PMID 24316736 DOI: 10.1038/Nchembio.1412  0.285
2012 Nelson B, Sidhu SS. Synthetic antibody libraries. Methods in Molecular Biology (Clifton, N.J.). 899: 27-41. PMID 22735944 DOI: 10.1007/978-1-61779-921-1_2  0.285
2020 Watchmaker P, Choe J, Simic M, Gilbert R, li A, Krasnow N, Carrera D, Yu W, Downey K, Celli A, Cho J, Briones J, Dannenfelser R, Cardarelli L, Sidhu S, et al. IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA Neuro-Oncology. 22: ii111-ii112. DOI: 10.1093/neuonc/noaa215.463  0.284
2021 Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, ... ... Sidhu SS, et al. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Science Translational Medicine. 13. PMID 33910979 DOI: 10.1126/scitranslmed.abe7378  0.281
2013 Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proceedings of the National Academy of Sciences of the United States of America. 110: 17832-7. PMID 24127596 DOI: 10.1073/Pnas.1317118110  0.281
2004 Fellouse FA, Wiesmann C, Sidhu SS. Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proceedings of the National Academy of Sciences of the United States of America. 101: 12467-72. PMID 15306681 DOI: 10.1073/pnas.0401786101  0.28
2001 Sidhu SS. Phage display in pharmaceutical biotechnology. Current Opinion in Biotechnology. 11: 610-6. PMID 11102798 DOI: 10.1016/S0958-1669(00)00152-X  0.279
2010 Fisher RD, Ultsch M, Lingel A, Schaefer G, Shao L, Birtalan S, Sidhu SS, Eigenbrot C. Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine Journal of Molecular Biology. 402: 217-229. PMID 20654626 DOI: 10.1016/j.jmb.2010.07.027  0.278
2015 Van Deventer JA, Kelly RL, Rajan S, Wittrup KD, Sidhu SS. A switchable yeast display/secretion system. Protein Engineering, Design & Selection : Peds. 28: 317-25. PMID 26333274 DOI: 10.1093/Protein/Gzv043  0.277
2019 Tao Y, Mis M, Blazer L, Ustav M, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice. Elife. 8. PMID 31452509 DOI: 10.7554/Elife.46134  0.276
2015 Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, ... ... Sidhu SS, et al. Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods. PMID 26121405 DOI: 10.1038/Nmeth.3472  0.276
2016 Gakhal AK, Jensen TJ, Bozoky Z, Roldan A, Lukacs GL, Forman-Kay J, Riordan JR, Sidhu SS. Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator. Mabs. 0. PMID 27185291 DOI: 10.1080/19420862.2016.1186320  0.275
2005 Fellouse FA, Li B, Compaan DM, Peden AA, Hymowitz SG, Sidhu SS. Molecular recognition by a binary code. Journal of Molecular Biology. 348: 1153-62. PMID 15854651 DOI: 10.1016/j.jmb.2005.03.041  0.274
2017 Miersch S, Kuruganti S, Walter MR, Sidhu SS. A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family. Protein Engineering, Design & Selection : Peds. 30: 697-704. PMID 28981904 DOI: 10.1093/protein/gzx048  0.274
2006 Fellouse FA, Barthelemy PA, Kelley RF, Sidhu SS. Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code. Journal of Molecular Biology. 357: 100-14. PMID 16413576 DOI: 10.1016/j.jmb.2005.11.092  0.274
2012 Laver JD, Ancevicius K, Sollazzo P, Westwood JT, Sidhu SS, Lipshitz HD, Smibert CA. Synthetic antibodies as tools to probe RNA-binding protein function. Molecular Biosystems. 8: 1650-7. PMID 22481296 DOI: 10.1039/C2Mb00007E  0.273
2023 Veggiani G, Sidhu SS. Generation and Selection of Synthetic Human Antibody Libraries via Phage Display. Cold Spring Harbor Protocols. PMID 37295821 DOI: 10.1101/pdb.prot108347  0.273
2003 Schaffer ML, Deshayes K, Nakamura G, Sidhu S, Skelton NJ. Complex with a Phage Display-Derived Peptide Provides Insight into the Function of Insulin-like Growth Factor I Biochemistry. 42: 9324-9334. PMID 12899619 DOI: 10.1021/Bi034386C  0.272
2002 Vajdos FF, Adams CW, Breece TN, Presta LG, de Vos AM, Sidhu SS. Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis. Journal of Molecular Biology. 320: 415-28. PMID 12079396 DOI: 10.1016/S0022-2836(02)00264-4  0.272
2018 Saxena A, Bai B, Hou SC, Jiang L, Ying T, Miersch S, Sidhu SS, Wu D. Fc Engineering: Tailored Synthetic Human IgG1-Fc Repertoire for High-Affinity Interaction with FcRn at pH 6.0. Methods in Molecular Biology (Clifton, N.J.). 1827: 399-417. PMID 30196509 DOI: 10.1007/978-1-4939-8648-4_21  0.272
2004 Lee CV, Liang WC, Dennis MS, Eigenbrot C, Sidhu SS, Fuh G. High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold. Journal of Molecular Biology. 340: 1073-93. PMID 15236968 DOI: 10.1016/j.jmb.2004.05.051  0.272
2020 Gallo E, Kelil A, Bayliss PE, Jeganathan A, Egorova O, Ploder L, Adams JA, Giblin P, Sidhu SS. antibody phage display yields optimal inhibitors of integrin α11/β1. Mabs. 12: 1717265. PMID 31980006 DOI: 10.1080/19420862.2020.1717265  0.271
2023 Veggiani G, Sidhu SS. Beyond Natural Immune Repertoires: Synthetic Antibodies. Cold Spring Harbor Protocols. PMID 37295822 DOI: 10.1101/pdb.top107768  0.271
2020 Hanna R, Cardarelli L, Patel N, Blazer LL, Adams JJ, Sidhu SS. A phage-displayed single-chain Fab library optimized for rapid production of single-chain IgGs. Protein Science : a Publication of the Protein Society. PMID 32803886 DOI: 10.1002/pro.3931  0.27
2018 Luz D, Shiga EA, Chen G, Quintilio W, Andrade FB, Maranhão AQ, Caetano BA, Mitsunari T, Silva MA, Rocha LB, Moro AM, Sidhu SS, Piazza RMF. Structural Changes in Stx1 Engineering Monoclonal Antibody Improves Its Functionality as Diagnostic Tool for a Rapid Latex Agglutination Test. Antibodies (Basel, Switzerland). 7. PMID 31544861 DOI: 10.3390/antib7010009  0.27
2022 Xiang J, Su J, Lan Q, Zhao W, Zhou Y, Xu Y, Niu J, Xia S, Qi Q, Sidhu S, Lu L, Miersch S, Yang B. Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein. Communications Biology. 5: 1179. PMID 36333470 DOI: 10.1038/s42003-022-04160-8  0.267
2012 Rajan S, Sidhu SS. Simplified synthetic antibody libraries. Methods in Enzymology. 502: 3-23. PMID 22208979 DOI: 10.1016/B978-0-12-416039-2.00001-X  0.267
2016 Nilvebrant J, Tessier PM, Sidhu SS. Engineered autonomous human variable domains. Current Pharmaceutical Design. PMID 27655414 DOI: 10.2174/1381612822666160921143011  0.267
2017 Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS. Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif. Protein Science : a Publication of the Protein Society. PMID 28276594 DOI: 10.1002/Pro.3155  0.267
2020 Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, et al. Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chemical Biology. PMID 32726587 DOI: 10.1016/J.Chembiol.2020.07.010  0.266
2015 Chen G, Gorelik L, Simon KJ, Pavlenco A, Cheung A, Brickelmaier M, Chen LL, Jin P, Weinreb PH, Sidhu SS. Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1. Mabs. 7: 681-92. PMID 25879139 DOI: 10.1080/19420862.2015.1038447  0.265
2004 Sidhu SS, Li B, Chen Y, Fellouse FA, Eigenbrot C, Fuh G. Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions. Journal of Molecular Biology. 338: 299-310. PMID 15066433 DOI: 10.1016/j.jmb.2004.02.050  0.265
2022 Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey R, Sidhu SS, Leung DW, Amarasinghe GK. Development of monoclonal antibodies to detect for SARS-CoV-2 proteins. Journal of Molecular Biology. 167583. PMID 35405107 DOI: 10.1016/j.jmb.2022.167583  0.264
2012 Miersch S, Sidhu SS. Synthetic antibodies: concepts, potential and practical considerations. Methods (San Diego, Calif.). 57: 486-98. PMID 22750306 DOI: 10.1016/j.ymeth.2012.06.012  0.262
2018 Huang G, Zhong Z, Miersch S, Sidhu SS, Hou SC, Wu D. Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity. Journal of Visualized Experiments : Jove. PMID 29782009 DOI: 10.3791/57357  0.261
2020 Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, ... ... Sidhu S, et al. Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32511401 DOI: 10.1101/2020.05.18.102038  0.261
2017 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. 23: 1384. PMID 29117169 DOI: 10.1038/Nm1117-1384D  0.259
2020 Han Z, Dash S, Sagum CA, Ruthel G, Jaladanki CK, Berry CT, Schwoerer MP, Harty NM, Freedman BD, Bedford MT, Fan H, Sidhu SS, Sudol M, Shtanko O, Harty RN. Modular Mimicry and Engagement of the Hippo Pathway by Marburg Virus VP40: Implications for Filovirus Biology and Budding. Plos Pathogens. 16: e1008231. PMID 31905227 DOI: 10.1371/Journal.Ppat.1008231  0.258
2021 Murdocca M, Citro G, Romeo I, Lupia A, Miersch S, Amadio B, Bonomo A, Rossi A, Sidhu SS, Pandolfi PP, Alcaro S, Sangiuolo FC, Novelli G. Peptide Platform as a Powerful Tool in the Fight against COVID-19. Viruses. 13. PMID 34452531 DOI: 10.3390/v13081667  0.257
2014 Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, Liu B, Teyra J, Pawson T, Moffat J, Li SS, Sidhu SS, Kim PM. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Proceedings of the National Academy of Sciences of the United States of America. 111: 2542-7. PMID 24550280 DOI: 10.1073/Pnas.1312296111  0.257
2008 Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh JH, Reva B, Held HA, Appleton BA, Evangelista M, Wu Y, Xin X, Chan AC, Seshagiri S, Lasky LA, Sander C, ... ... Sidhu SS, et al. A specificity map for the PDZ domain family. Plos Biology. 6: e239. PMID 18828675 DOI: 10.1371/Journal.Pbio.0060239  0.256
2009 Gao J, Sidhu SS, Wells JA. Two-state selection of conformation-specific antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 3071-6. PMID 19208804 DOI: 10.1073/Pnas.0812952106  0.255
2023 Tessier TM, Chowdhury A, Stekel Z, Fux J, Sartori MA, Teyra J, Jarvik N, Chung J, Kurinov I, Sicheri F, Sidhu SS, Singer AU, Zhang W. Structural and functional validation of a highly specific Smurf2 inhibitor. Protein Science : a Publication of the Protein Society. e4885. PMID 38147466 DOI: 10.1002/pro.4885  0.254
2021 Tang JQ, Veggiani G, Singer A, Teyra J, Chung J, Sidhu SS. A Panel of Engineered Ubiquitin Variants Targeting the Family of Domains Found in Ubiquitin Specific Proteases (DUSPs). Journal of Molecular Biology. 167300. PMID 34666042 DOI: 10.1016/j.jmb.2021.167300  0.254
2017 Chen G, Sidhu SS, Nilvebrant J. Synthetic Antibodies in Infectious Disease. Advances in Experimental Medicine and Biology. 1053: 79-98. PMID 29549636 DOI: 10.1007/978-3-319-72077-7_5  0.254
2018 Zhang W, Sidhu SS. Generating Intracellular Modulators of E3 Ligases and Deubiquitinases from Phage-Displayed Ubiquitin Variant Libraries. Methods in Molecular Biology (Clifton, N.J.). 1844: 101-119. PMID 30242706 DOI: 10.1007/978-1-4939-8706-1_8  0.253
2016 Zhang W, Ben-David M, Sidhu SS. Engineering cell signaling modulators from native protein-protein interactions. Current Opinion in Structural Biology. 45: 25-35. PMID 27866084 DOI: 10.1016/j.sbi.2016.11.002  0.253
2007 Runyon ST, Zhang Y, Appleton BA, Sazinsky SL, Wu P, Pan B, Wiesmann C, Skelton NJ, Sidhu SS. Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3. Protein Science : a Publication of the Protein Society. 16: 2454-71. PMID 17962403 DOI: 10.1110/Ps.073049407  0.253
2014 Chen G, Sidhu SS. Design and generation of synthetic antibody libraries for phage display. Methods in Molecular Biology (Clifton, N.J.). 1131: 113-31. PMID 24515463 DOI: 10.1007/978-1-62703-992-5_8  0.252
2019 Hu AX, Adams JJ, Vora P, Qazi M, Singh SK, Moffat J, Sidhu SS. EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF. Methods in Molecular Biology (Clifton, N.J.). 1869: 155-168. PMID 30324522 DOI: 10.1007/978-1-4939-8805-1_14  0.252
2011 Bradbury AR, Sidhu S, Dübel S, McCafferty J. Beyond natural antibodies: the power of in vitro display technologies. Nature Biotechnology. 29: 245-54. PMID 21390033 DOI: 10.1038/nbt.1791  0.251
2021 Luz D, Gómez FD, Ferreira RL, Melo BS, Guth BEC, Quintilio W, Moro AM, Presta A, Sacerdoti F, Ibarra C, Chen G, Sidhu SS, Amaral MM, Piazza RMF. The Deleterious Effects of Shiga Toxin Type 2 Are Neutralized In Vitro by FabF8:Stx2 Recombinant Monoclonal Antibody. Toxins. 13. PMID 34822608 DOI: 10.3390/toxins13110825  0.25
2023 Martyn GD, Veggiani G, Sidhu SS. Engineering SH2 Domains with Tailored Specificities and Affinities. Methods in Molecular Biology (Clifton, N.J.). 2705: 307-348. PMID 37668982 DOI: 10.1007/978-1-0716-3393-9_17  0.249
2019 Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, ... Sidhu SS, et al. Potent Neutralization of Staphylococcal Enterotoxin B in vivo by Antibodies that Block Binding to the T-Cell Receptor. Journal of Molecular Biology. PMID 30928493 DOI: 10.1016/J.Jmb.2019.03.017  0.249
2018 Veggiani G, Huang H, Yates BP, Tong J, Kaneko T, Joshi R, Li SS, Moran MF, Gish G, Sidhu SS. Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis. Protein Science : a Publication of the Protein Society. PMID 30431205 DOI: 10.1002/pro.3551  0.248
2009 Li B, Xi H, Diehl L, Lee WP, Sturgeon L, Chinn J, Deforge L, Kelley RF, Wiesmann C, van Lookeren Campagne M, Sidhu SS. Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation. The Journal of Biological Chemistry. 284: 35605-11. PMID 19833734 DOI: 10.1074/Jbc.M109.035170  0.247
2022 Miersch S, de la Rosa G, Friis R, Ledsgaard L, Boddum K, Laustsen AH, Sidhu SS. Synthetic antibodies block receptor binding and current-inhibiting effects of α-cobratoxin from Naja kaouthia. Protein Science : a Publication of the Protein Society. 31: e4296. PMID 35481650 DOI: 10.1002/pro.4296  0.247
2007 Zhang Y, Appleton BA, Wu P, Wiesmann C, Sidhu SS. Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain. Protein Science : a Publication of the Protein Society. 16: 1738-50. PMID 17656586 DOI: 10.1110/Ps.072833207  0.246
2009 Koide S, Sidhu SS. The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. Acs Chemical Biology. 4: 325-34. PMID 19298050 DOI: 10.1021/Cb800314V  0.246
2017 Teyra J, Huang H, Jain S, Guan X, Dong A, Liu Y, Tempel W, Min J, Tong Y, Kim PM, Bader GD, Sidhu SS. Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities. Structure (London, England : 1993). PMID 28890361 DOI: 10.1016/j.str.2017.07.017  0.246
2013 Persson H, Ye W, Wernimont A, Adams JJ, Koide A, Koide S, Lam R, Sidhu SS. CDR-H3 diversity is not required for antigen recognition by synthetic antibodies. Journal of Molecular Biology. 425: 803-11. PMID 23219464 DOI: 10.1016/J.Jmb.2012.11.037  0.246
2012 Huang H, Sidhu SS. Studying binding specificities of peptide recognition modules by high-throughput phage display selections. Methods in Molecular Biology (Clifton, N.J.). 781: 87-97. PMID 21877279 DOI: 10.1007/978-1-61779-276-2_6  0.245
2007 Sidhu SS, Koide S. Phage display for engineering and analyzing protein interaction interfaces. Current Opinion in Structural Biology. 17: 481-7. PMID 17870470 DOI: 10.1016/J.Sbi.2007.08.007  0.245
2013 Orava EW, Jarvik N, Shek YL, Sidhu SS, Gariépy J. A short DNA aptamer that recognizes TNFα and blocks its activity in Vitro Acs Chemical Biology. 8: 170-178. PMID 23046187 DOI: 10.1021/cb3003557  0.244
2017 Huang H, Kaneko T, Sidhu SS, Li SS. Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain. Methods in Molecular Biology (Clifton, N.J.). 1555: 225-254. PMID 28092036 DOI: 10.1007/978-1-4939-6762-9_13  0.243
2003 Sidhu SS, Bader GD, Boone C. Functional genomics of intracellular peptide recognition domains with combinatorial biology methods. Current Opinion in Chemical Biology. 7: 97-102. PMID 12547433 DOI: 10.1016/S1367-5931(02)00011-X  0.243
2019 Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S. Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases. Journal of Molecular Biology. PMID 30763569 DOI: 10.1016/J.Jmb.2019.02.007  0.242
2016 Leung I, Dekel A, Shifman JM, Sidhu SS. Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21. Proceedings of the National Academy of Sciences of the United States of America. PMID 27436899 DOI: 10.1073/pnas.1524648113  0.241
2011 Gfeller D, Butty F, Wierzbicka M, Verschueren E, Vanhee P, Huang H, Ernst A, Dar N, Stagljar I, Serrano L, Sidhu SS, Bader GD, Kim PM. The multiple-specificity landscape of modular peptide recognition domains. Molecular Systems Biology. 7: 484. PMID 21525870 DOI: 10.1038/Msb.2011.18  0.241
2017 Zhang W, Sartori MA, Makhnevych T, Federowicz KE, Dong X, Liu L, Nim S, Dong A, Yang J, Li Y, Haddad D, Ernst A, Heerding D, Tong Y, Moffat J, ... Sidhu SS, et al. Generation and validation of intracellular ubiquitin variant inhibitors for USP7 and USP10. Journal of Molecular Biology. PMID 28587923 DOI: 10.1016/J.Jmb.2017.05.025  0.241
2018 Kini RM, Sidhu SS, Laustsen AH. Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims. Toxins. 10. PMID 30551565 DOI: 10.3390/Toxins10120534  0.239
2012 Geyer CR, McCafferty J, Dübel S, Bradbury AR, Sidhu SS. Recombinant antibodies and in vitro selection technologies. Methods in Molecular Biology (Clifton, N.J.). 901: 11-32. PMID 22723092 DOI: 10.1007/978-1-61779-931-0_2  0.238
2019 Teyra J, Ernst A, Singer A, Sicheri F, Sidhu SS. Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities. Protein Science : a Publication of the Protein Society. PMID 31654425 DOI: 10.1002/Pro.3759  0.238
2014 Chen G, Koellhoffer JF, Zak SE, Frei JC, Liu N, Long H, Ye W, Nagar K, Pan G, Chandran K, Dye JM, Sidhu SS, Lai JR. Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge. Acs Chemical Biology. 9: 2263-73. PMID 25140871 DOI: 10.1021/Cb5006454  0.237
2006 Sidhu SS, Fellouse FA. Synthetic therapeutic antibodies. Nature Chemical Biology. 2: 682-8. PMID 17108986 DOI: 10.1038/nchembio843  0.237
2020 Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe GK, Henderson JP, Miersch S, ... ... Sidhu S, et al. Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. Ssrn. 3606354. PMID 32714117 DOI: 10.2139/ssrn.3606354  0.237
2021 Teyra J, McLaughlin M, Singer A, Kelil A, Ernst A, Sicheri F, Sidhu SS. Comprehensive Assessment of The Relationship Between Site Specificity and Helix α2 in the Erbin PDZ Domain. Journal of Molecular Biology. 167115. PMID 34171344 DOI: 10.1016/j.jmb.2021.167115  0.237
2012 Kaneko T, Huang H, Cao X, Li X, Li C, Voss C, Sidhu SS, Li SSC. Superbinder SH2 domains act as antagonists of cell signaling Science Signaling. 5. PMID 23012655 DOI: 10.1126/scisignal.2003021  0.236
2013 Ma X, Barthelemy PA, Rouge L, Wiesmann C, Sidhu SS. Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor. Journal of Molecular Biology. 425: 2247-59. PMID 23507309 DOI: 10.1016/j.jmb.2013.03.020  0.236
2007 Sidhu SS, Kossiakoff AA. Exploring and designing protein function with restricted diversity. Current Opinion in Chemical Biology. 11: 347-54. PMID 17500026 DOI: 10.1016/J.Cbpa.2007.05.001  0.235
2000 Fuh G, Pisabarro MT, Li Y, Quan C, Lasky LA, Sidhu SS. Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display. The Journal of Biological Chemistry. 275: 21486-91. PMID 10887205 DOI: 10.1074/JBC.275.28.21486  0.234
2017 Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS. Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. Plos Pathogens. 13: e1006372. PMID 28542609 DOI: 10.1371/Journal.Ppat.1006372  0.234
2012 Kim T, Tyndel MS, Huang H, Sidhu SS, Bader GD, Gfeller D, Kim PM. MUSI: an integrated system for identifying multiple specificity from very large peptide or nucleic acid data sets. Nucleic Acids Research. 40: e47. PMID 22210894 DOI: 10.1093/nar/gkr1294  0.234
2002 Skelton NJ, Koehler MF, Zobel K, Wong WL, Yeh S, Pisabarro MT, Yin JP, Lasky LA, Sidhu SS. Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain. The Journal of Biological Chemistry. 278: 7645-54. PMID 12446668 DOI: 10.1074/jbc.M209751200  0.232
2016 Tong J, Cao B, Martyn GD, Krieger JR, Taylor P, Yates B, Sidhu SS, Li SS, Mao X, Moran MF. Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS. Proteomics. PMID 27880036 DOI: 10.1002/pmic.201600360  0.232
2008 Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, et al. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell. 134: 668-78. PMID 18724939 DOI: 10.1016/J.Cell.2008.07.039  0.231
2019 Zhang Y, Sun X, Qian Y, Yi H, Song K, Zhu H, Zonta F, Chen W, Ji Q, Miersch S, Sidhu SS, Wu D. A potent anti-SpuE antibody allosterically inhibits type III secretion system and attenuates virulence of Pseudomonas aeruginosa. Journal of Molecular Biology. PMID 31682834 DOI: 10.1016/j.jmb.2019.10.026  0.231
2014 Van Deventer JA, Dane Wittrup K, Rajan S, Sidhu SS. A yeast-based approach to the development of antibodies targeting cancer-associated fibroblasts Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972963  0.231
2016 Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS. Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976582 DOI: 10.1073/Pnas.1519389113  0.231
2019 Gabrielsen M, Buetow L, Kowalczyk D, Zhang W, Sidhu SS, Huang DT. Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation. Structure (London, England : 1993). PMID 31303481 DOI: 10.1016/J.Str.2019.06.008  0.23
2011 Kaneko T, Sidhu SS, Li SS. Evolving specificity from variability for protein interaction domains. Trends in Biochemical Sciences. 36: 183-90. PMID 21227701 DOI: 10.1016/j.tibs.2010.12.001  0.229
2011 Yip KY, Utz L, Sitwell S, Hu X, Sidhu SS, Turk BE, Gerstein M, Kim PM. Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps. Bmc Biology. 9: 53. PMID 21835011 DOI: 10.1186/1741-7007-9-53  0.228
2021 Nilvebrant J, Ereño-Orbea J, Gorelik M, Julian MC, Tessier PM, Julien JP, Sidhu SS. Systematic engineering of optimized autonomous heavy-chain variable domains. Journal of Molecular Biology. 167241. PMID 34508727 DOI: 10.1016/j.jmb.2021.167241  0.228
2014 Murciano-Calles J, McLaughlin ME, Erijman A, Hooda Y, Chakravorty N, Martinez JC, Shifman JM, Sidhu SS. Alteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects. Journal of Molecular Biology. 426: 3500-8. PMID 24813123 DOI: 10.1016/j.jmb.2014.05.003  0.227
2021 Ma Y, Chen K, Xia F, Atwal R, Wang H, Ahmed SU, Cardarelli L, Lui I, Duong B, Wang Z, Wells JA, Sidhu SS, Kelley SO. Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture. Acs Nano. PMID 34813293 DOI: 10.1021/acsnano.1c03935  0.227
2013 Xin X, Gfeller D, Cheng J, Tonikian R, Sun L, Guo A, Lopez L, Pavlenco A, Akintobi A, Zhang Y, Rual JF, Currell B, Seshagiri S, Hao T, Yang X, ... ... Sidhu SS, et al. SH3 interactome conserves general function over specific form. Molecular Systems Biology. 9: 652. PMID 23549480 DOI: 10.1038/Msb.2013.9  0.227
2022 Labriola JM, Miersch S, Chen G, Chen C, Pavlenco A, Saberianfar R, Caccuri F, Zani A, Sharma N, Feng A, Leung DW, Caruso A, Novelli G, Amarasinghe GK, Sidhu SS. Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants. Acs Chemical Biology. PMID 35731947 DOI: 10.1021/acschembio.2c00411  0.227
2014 Adams JJ, Sidhu SS. Synthetic antibody technologies. Current Opinion in Structural Biology. 24: 1-9. PMID 24721448 DOI: 10.1016/j.sbi.2013.11.003  0.226
2016 Miersch S, Sidhu SS. Intracellular targeting with engineered proteins. F1000research. 5. PMID 27547383 DOI: 10.12688/f1000research.8915.1  0.224
2008 Yeh JH, Sidhu SS, Chan AC. Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell. 132: 846-59. PMID 18329370 DOI: 10.1016/j.cell.2008.01.013  0.224
2019 Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, et al. Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America. PMID 31350353 DOI: 10.1073/Pnas.1902889116  0.223
2006 Zhang Y, Yeh S, Appleton BA, Held HA, Kausalya PJ, Phua DC, Wong WL, Lasky LA, Wiesmann C, Hunziker W, Sidhu SS. Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families. The Journal of Biological Chemistry. 281: 22299-311. PMID 16737968 DOI: 10.1074/Jbc.M602902200  0.222
2021 Le PJ, Miersch S, Forbes MW, Jarvik N, Ku A, Sidhu SS, Reilly RM, Winnik MA. Site-Specific Conjugation of Metal-Chelating Polymers to Anti-Frizzled-2 Antibodies Microbial Transglutaminase. Biomacromolecules. PMID 33961407 DOI: 10.1021/acs.biomac.1c00246  0.222
2022 Spitalieri P, Centofanti F, Murdocca M, Scioli MG, Latini A, Di Cesare S, Citro G, Rossi A, Orlandi A, Miersch S, Sidhu SS, Pandolfi PP, Botta A, Sangiuolo F, Novelli G. Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids. Cells. 11. PMID 35406799 DOI: 10.3390/cells11071235  0.222
2007 Tonikian R, Zhang Y, Boone C, Sidhu SS. Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries. Nature Protocols. 2: 1368-86. PMID 17545975 DOI: 10.1038/Nprot.2007.151  0.222
2023 Henneberg LT, Singh J, Duda DM, Baek K, Yanishevski D, Murray PJ, Mann M, Sidhu SS, Schulman B. Activity-based profiling of cullin-RING ligase networks by conformation-specific probes. Biorxiv : the Preprint Server For Biology. PMID 36711970 DOI: 10.1101/2023.01.14.524048  0.221
2010 Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D, Bader GD, Sidhu SS, Vandekerckhove J, Gettemans J, Sudol M. Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. The Biochemical Journal. 432: 461-72. PMID 20868367 DOI: 10.1042/Bj20100870  0.22
2009 Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS. Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nature Chemical Biology. 5: 217-9. PMID 19252499 DOI: 10.1038/Nchembio.152  0.22
2010 Ernst A, Gfeller D, Kan Z, Seshagiri S, Kim PM, Bader GD, Sidhu SS. Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing. Molecular Biosystems. 6: 1782-90. PMID 20714644 DOI: 10.1039/C0Mb00061B  0.22
2019 Tao Y, Mis M, Blazer L, Jnr MU, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. Author response: Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice Elife. DOI: 10.7554/Elife.46134.028  0.22
2014 Gfeller D, Ernst A, Jarvik N, Sidhu SS, Bader GD. Prediction and experimental characterization of nsSNPs altering human PDZ-binding motifs. Plos One. 9: e94507. PMID 24722214 DOI: 10.1371/Journal.Pone.0094507  0.219
2008 Michnick SW, Sidhu SS. Submitting antibodies to binding arbitration. Nature Chemical Biology. 4: 326-9. PMID 18488004 DOI: 10.1038/Nchembio0608-326  0.219
2005 Pál G, Fong SY, Kossiakoff AA, Sidhu SS. Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Science : a Publication of the Protein Society. 14: 2405-13. PMID 16131663 DOI: 10.1110/Ps.051519805  0.219
2007 Sidhu SS. Full-length antibodies on display. Nature Biotechnology. 25: 537-8. PMID 17483836 DOI: 10.1038/nbt0507-537  0.217
2018 Ben-David M, Huang H, Sun MGF, Corbi-Verge C, Petsalaki E, Liu K, Gfeller D, Garg P, Tempel W, Sochirca I, Shifman JM, Davidson A, Min J, Kim PM, Sidhu SS. Allosteric Modulation of Binding Specificity by Alternative Packing of Protein Cores. Journal of Molecular Biology. PMID 30471255 DOI: 10.1016/J.Jmb.2018.11.018  0.216
2019 Newsted D, Banerjee S, Watt K, Nersesian S, Truesdell P, Blazer LL, Cardarelli L, Adams JJ, Sidhu SS, Craig AW. Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models. Oncoimmunology. 8: e1539613. PMID 30713798 DOI: 10.1080/2162402X.2018.1539613  0.216
2012 Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR. Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein. Chembiochem : a European Journal of Chemical Biology. 13: 2549-57. PMID 23111988 DOI: 10.1002/Cbic.201200493  0.216
2013 Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, ... ... Sidhu SS, et al. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 152: 1008-20. PMID 23452850 DOI: 10.1016/J.Cell.2013.01.056  0.215
2009 Tonikian R, Xin X, Toret CP, Gfeller D, Landgraf C, Panni S, Paoluzi S, Castagnoli L, Currell B, Seshagiri S, Yu H, Winsor B, Vidal M, Gerstein MB, Bader GD, ... ... Sidhu SS, et al. Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. Plos Biology. 7: e1000218. PMID 19841731 DOI: 10.1371/Journal.Pbio.1000218  0.214
2005 Bond CJ, Wiesmann C, Marsters JC, Sidhu SS. A structure-based database of antibody variable domain diversity. Journal of Molecular Biology. 348: 699-709. PMID 15826665 DOI: 10.1016/j.jmb.2005.02.063  0.213
2019 Veggiani G, Gerpe MCR, Sidhu SS, Zhang W. Emerging drug development technologies targeting Ubiquitination for Cancer therapeutics. Pharmacology & Therapeutics. PMID 30851297 DOI: 10.1016/j.pharmthera.2019.03.003  0.212
2014 Ernst A, Appleton BA, Ivarsson Y, Zhang Y, Gfeller D, Wiesmann C, Sidhu SS. A structural portrait of the PDZ domain family. Journal of Molecular Biology. 426: 3509-19. PMID 25158098 DOI: 10.1016/J.Jmb.2014.08.012  0.212
2017 Ghosh E, Srivastava A, Baidya M, Kumari P, Dwivedi H, Nidhi K, Ranjan R, Dogra S, Koide A, Yadav PN, Sidhu SS, Koide S, Shukla AK. A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis. Nature Nanotechnology. PMID 28967893 DOI: 10.1038/Nnano.2017.188  0.211
2012 Teyra J, Sidhu SS, Kim PM. Elucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domains. Febs Letters. 586: 2631-7. PMID 22691579 DOI: 10.1016/j.febslet.2012.05.043  0.21
2010 Lam HY, Kim PM, Mok J, Tonikian R, Sidhu SS, Turk BE, Snyder M, Gerstein MB. MOTIPS: automated motif analysis for predicting targets of modular protein domains. Bmc Bioinformatics. 11: 243. PMID 20459839 DOI: 10.1186/1471-2105-11-243  0.21
2006 Appleton BA, Zhang Y, Wu P, Yin JP, Hunziker W, Skelton NJ, Sidhu SS, Wiesmann C. Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. The Journal of Biological Chemistry. 281: 22312-20. PMID 16737969 DOI: 10.1074/Jbc.M602901200  0.21
2015 Ren L, Willet AH, Roberts-Galbraith RH, McDonald NA, Feoktistova A, Chen JS, Huang H, Guillen R, Boone C, Sidhu SS, Beckley JR, Gould KL. The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast. Molecular Biology of the Cell. 26: 256-69. PMID 25428987 DOI: 10.1091/Mbc.E14-10-1451  0.21
2015 Kuruganti S, Miersch S, Deshpande A, Speir JA, Harris BD, Schriewer JM, Buller RM, Sidhu SS, Walter MR. Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes. The Journal of Biological Chemistry. PMID 26546677 DOI: 10.1074/jbc.M115.665943  0.209
2019 Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F. Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. Protein Science : a Publication of the Protein Society. PMID 30793400 DOI: 10.1002/Pro.3593  0.209
2023 Henneberg LT, Singh J, Duda DM, Baek K, Yanishevski D, Murray PJ, Mann M, Sidhu SS, Schulman BA. Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nature Chemical Biology. PMID 37653169 DOI: 10.1038/s41589-023-01392-5  0.209
2003 Sidhu SS, Fairbrother WJ, Deshayes K. Exploring protein-protein interactions with phage display. Chembiochem : a European Journal of Chemical Biology. 4: 14-25. PMID 12512072 DOI: 10.1002/cbic.200390008  0.209
2017 Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN. Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 to Regulate Egress. Journal of Virology. PMID 28768865 DOI: 10.1128/Jvi.00812-17  0.209
2022 van Vliet VJE, Huynh N, Palà J, Patel A, Singer A, Slater C, Chung J, van Huizen M, Teyra J, Miersch S, Luu GK, Ye W, Sharma N, Ganaie SS, Russell R, ... ... Sidhu SS, et al. Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. Plos Pathogens. 18: e1011065. PMID 36548304 DOI: 10.1371/journal.ppat.1011065  0.209
2002 Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. The Journal of Biological Chemistry. 277: 12906-14. PMID 11821434 DOI: 10.1074/jbc.M200818200  0.208
2012 McCluskey AJ, Bolewska-Pedyczak E, Jarvik N, Chen G, Sidhu SS, Gariépy J. Charged and hydrophobic surfaces on the a chain of Shiga-Like toxin 1 recognize the C-Terminal domain of ribosomal stalk proteins Plos One. 7. PMID 22355345 DOI: 10.1371/journal.pone.0031191  0.208
2004 Skelton NJ, Schaffer ML, Deshayes K, Blandl T, Runyon S, Nakamura G, Sidhu SS. Phage display-derived ligands provide structural insight into insulin-like growth factor I function Spectroscopy. 18: 237-249. DOI: 10.1155/2004/142593  0.207
2017 Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. Plos Pathogens. 13: e1006132. PMID 28076420 DOI: 10.1371/Journal.Ppat.1006132  0.207
2000 Fuh G, Sidhu SS. Efficient phage display of polypeptides fused to the carboxy-terminus of the M13 gene-3 minor coat protein. Febs Letters. 480: 231-4. PMID 11034335 DOI: 10.1016/S0014-5793(00)01946-3  0.204
2013 Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Sidhu SS, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/Science.1230161  0.204
2016 Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, ... ... Sidhu SS, et al. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Molecular Cell. PMID 26949039 DOI: 10.1016/J.Molcel.2016.02.005  0.203
2017 Gorelik M, Sidhu SS. Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants. Bioengineering & Translational Medicine. 2: 31-42. PMID 28580429 DOI: 10.1002/btm2.10044  0.202
2006 Pál G, Kouadio JL, Artis DR, Kossiakoff AA, Sidhu SS. Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. The Journal of Biological Chemistry. 281: 22378-85. PMID 16762925 DOI: 10.1074/Jbc.M603826200  0.202
2004 Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS. Definition of the consensus motif recognized by gamma-adaptin ear domains. The Journal of Biological Chemistry. 279: 8018-28. PMID 14665628 DOI: 10.1074/Jbc.M311873200  0.202
2015 Uchime O, Dai Z, Biris N, Lee D, Sidhu SS, Li S, Lai JR, Gavathiotis E. Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. The Journal of Biological Chemistry. PMID 26565029 DOI: 10.1074/jbc.M115.680918  0.201
2023 Bruce HA, Singer AU, Filippova EV, Blazer LL, Adams JJ, Enderle L, Ben-David M, Radley EH, Mao DYL, Pau V, Orlicky S, Sicheri F, Kourinov I, Atwell S, Kossiakoff AA, ... Sidhu SS, et al. Engineered Antigen-Binding Fragments for Enhanced Crystallization of Antibody:Antigen Complexes. Protein Science : a Publication of the Protein Society. e4824. PMID 37945533 DOI: 10.1002/pro.4824  0.201
2000 Sidhu SS, Weiss GA, Wells JA. High copy display of large proteins on phage for functional selections. Journal of Molecular Biology. 296: 487-95. PMID 10669603 DOI: 10.1006/Jmbi.1999.3465  0.201
2012 Zalatan JG, Coyle SM, Rajan S, Sidhu SS, Lim WA. Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (New York, N.Y.). 337: 1218-22. PMID 22878499 DOI: 10.1126/Science.1220683  0.201
2023 Sawula E, Miersch S, Jong ED, Li C, Chou FY, Tang JK, Saberianfar R, Harding J, Sidhu SS, Nagy A. Cell-based passive immunization for protection against SARS-CoV-2 infection. Stem Cell Research & Therapy. 14: 318. PMID 37932852 DOI: 10.1186/s13287-023-03556-5  0.2
2018 Gorelik M, Manczyk N, Pavlenco A, Kurinov I, Sidhu SS, Sicheri F. A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure (London, England : 1993). PMID 30033217 DOI: 10.1016/J.Str.2018.06.004  0.2
2019 Amatya P, Wagner N, Chen G, Luthra P, Shi L, Borek D, Pavlenco A, Rohrs HW, Basler CF, Sidhu SS, Gross ML, Leung DW. Marburg virus RNA synthesis is inhibited by a synthetic anti-VP35 antibody. Acs Infectious Diseases. PMID 31120240 DOI: 10.1021/ACSINFECDIS.9B00091  0.2
2021 Marinec PS, Landgraf KE, Uppalapati M, Chen G, Xie D, Jiang Q, Zhao Y, Petriello A, Deshayes K, Kent SBH, Ault-Riche D, Sidhu SS. A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chemical Biology. PMID 33621466 DOI: 10.1021/acschembio.1c00017  0.2
2017 Zhang H, Liu K, Izumi N, Huang H, Ding D, Ni Z, Sidhu SS, Chen C, Tomari Y, Min J. Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proceedings of the National Academy of Sciences of the United States of America. PMID 29118143 DOI: 10.1073/Pnas.1711486114  0.198
2018 Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Haybe Z, Fu Y, Mascall K, Pan J, Angers S, Moffat J, Sidhu SS, et al. Structure-guided engineering fine-tunes pharmacokinetics, tolerability and anti-tumor profile of anti-frizzled antibody Acta Crystallographica Section a Foundations and Advances. 74: a297-a297. DOI: 10.1107/S0108767318097039  0.197
2009 Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS. Rapid evolution of functional complexity in a domain family. Science Signaling. 2: ra50. PMID 19738200 DOI: 10.1126/Scisignal.2000416  0.197
2018 Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress. Diseases (Basel, Switzerland). 6. PMID 30011814 DOI: 10.3390/Diseases6030064  0.196
2021 Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications. 12: 7032. PMID 34857742 DOI: 10.1038/s41467-021-26983-5  0.196
2021 Chidiac R, Abedin M, Macleod G, Yang A, Thibeault PE, Blazer LL, Adams JJ, Zhang L, Roehrich H, Jo HN, Seshagiri S, Sidhu SS, Junge HJ, Angers S. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. Embo Molecular Medicine. e13977. PMID 34105895 DOI: 10.15252/emmm.202113977  0.195
2021 Suryamohan K, Diwanji D, Stawiski EW, Gupta R, Miersch S, Liu J, Chen C, Jiang YP, Fellouse FA, Sathirapongsasuti JF, Albers PK, Deepak T, Saberianfar R, Ratan A, Washburn G, ... ... Sidhu S, et al. Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2. Communications Biology. 4: 475. PMID 33846513 DOI: 10.1038/s42003-021-02030-3  0.194
2022 McClary WD, Catala A, Zhang W, Gamboni F, Dzieciatkowska M, Sidhu SS, D'Alessandro A, Catalano CE. A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells. Acs Chemical Biology. PMID 35796308 DOI: 10.1021/acschembio.2c00256  0.194
2003 Bond CJ, Marsters JC, Sidhu SS. Contributions of CDR3 to V H H domain stability and the design of monobody scaffolds for naive antibody libraries. Journal of Molecular Biology. 332: 643-55. PMID 12963373 DOI: 10.1016/S0022-2836(03)00967-7  0.194
2021 Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, Sattler M, Prabu JR, Sidhu SS, Schulman BA. Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. Journal of Molecular Biology. 434: 167347. PMID 34767800 DOI: 10.1016/j.jmb.2021.167347  0.193
2014 Jeon J, Nim S, Teyra J, Datti A, Wrana JL, Sidhu SS, Moffat J, Kim PM. A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening. Genome Medicine. 6: 57. PMID 25165489 DOI: 10.1186/S13073-014-0057-7  0.193
2021 Zeitler L, Fiore A, Meyer C, Russier M, Zanella G, Suppmann S, Gagaro M, Sidhu SS, Seshagiri S, Ohnmacht C, Köcher T, Fallarino F, Linkermann A, Murray PJ. Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism. Elife. 10. PMID 33646117 DOI: 10.7554/eLife.64806  0.192
2017 Ling B, Watt K, Banerjee S, Newsted D, Truesdell P, Adams J, Sidhu SS, Craig AWB. A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models. Oncotarget. 8: 58372-58385. PMID 28938563 DOI: 10.18632/oncotarget.17702  0.192
2017 Ling B, Watt K, Banerjee S, Newsted D, Truesdell P, Adams J, Sidhu SS, Craig AW. A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models. Oncotarget. PMID 28537911 DOI: 10.18632/oncotarget.17702  0.192
2021 Middleton AJ, Teyra J, Zhu J, Sidhu SS, Day CL. Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chemical Biology. PMID 34397214 DOI: 10.1021/acschembio.1c00445  0.191
2021 Ganaie SS, Schwarz MM, McMillen CM, Price DA, Feng AX, Albe JR, Wang W, Miersch S, Orvedahl A, Cole AR, Sentmanat MF, Mishra N, Boyles DA, Koenig ZT, Kujawa MR, ... ... Sidhu SS, et al. Lrp1 is a host entry factor for Rift Valley fever virus. Cell. PMID 34559985 DOI: 10.1016/j.cell.2021.09.001  0.191
2008 Gilbreth RN, Esaki K, Koide A, Sidhu SS, Koide S. A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces. Journal of Molecular Biology. 381: 407-18. PMID 18602117 DOI: 10.1016/J.Jmb.2008.06.014  0.19
2016 Garrido-Urbani S, Garg P, Ghossoub R, Arnold R, Lembo F, Sundell GN, Kim PM, Lopez M, Zimmermann P, Sidhu SS, Ivarsson Y. Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin. Febs Letters. 590: 3-12. PMID 26787460 DOI: 10.1002/1873-3468.12037  0.19
2022 Martyn GD, Veggiani G, Kusebauch U, Morrone SR, Yates BP, Singer AU, Tong J, Manczyk N, Gish G, Sun Z, Kurinov I, Sicheri F, Moran MF, Moritz RL, Sidhu SS. Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chemical Biology. PMID 35613471 DOI: 10.1021/acschembio.2c00051  0.19
2014 Yu CG, Tonikian R, Felsensteiner C, Jhingree JR, Desveaux D, Sidhu SS, Harris TJ. Peptide binding properties of the three PDZ domains of Bazooka (Drosophila Par-3). Plos One. 9: e86412. PMID 24466078 DOI: 10.1371/Journal.Pone.0086412  0.19
2019 Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, ... ... Sidhu SS, et al. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure (London, England : 1993). PMID 30713027 DOI: 10.1016/J.Str.2019.01.002  0.19
2003 Pal G, Kossiakoff AA, Sidhu SS. The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. Journal of Molecular Biology. 332: 195-204. PMID 12946357 DOI: 10.1016/S0022-2836(03)00898-2  0.189
2017 Gabrielsen M, Buetow L, Nakasone MA, Ahmed SF, Sibbet GJ, Smith BO, Zhang W, Sidhu SS, Huang DT. A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Molecular Cell. 68: 456-470.e10. PMID 29053960 DOI: 10.1016/J.Molcel.2017.09.027  0.188
2003 Deshayes K, Schaffer ML, Skelton NJ, Nakamura GR, Kadkhodayan S, Sidhu SS. Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function. Chemistry & Biology. 9: 495-505. PMID 11983338 DOI: 10.1016/S1074-5521(02)00129-1  0.187
2012 Ahmed SM, Thériault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. The Journal of Cell Biology. 199: 951-67. PMID 23209302 DOI: 10.1083/Jcb.201206051  0.185
2019 Garg P, Ceccarelli DF, Keszei AF, Kourinov I, Sicheri F, Sidhu SS. Structural and Functional Analysis of Ubiquitin-based inhibitors that Target the Backsides of E2 Enzymes. Journal of Molecular Biology. PMID 31634471 DOI: 10.1016/J.Jmb.2019.09.024  0.184
2022 Nardin C, Tettey-Matey A, Donati V, Marazziti D, Di Pietro C, Peres C, Raspa M, Zonta F, Yang G, Gorelik M, Singh S, Cardarelli L, Sidhu SS, Mammano F. A Quantitative Assay for Ca Uptake through Normal and Pathological Hemichannels. International Journal of Molecular Sciences. 23. PMID 35806342 DOI: 10.3390/ijms23137337  0.184
2022 Sankar K, Trainor K, Blazer LL, Adams JJ, Sidhu SS, Day T, Meiering E, Maier JKX. A Descriptor Set for Quantitative Structure-property Relationship Prediction in Biologics. Molecular Informatics. e2100240. PMID 35277930 DOI: 10.1002/minf.202100240  0.184
2008 Ye JD, Tereshko V, Frederiksen JK, Koide A, Fellouse FA, Sidhu SS, Koide S, Kossiakoff AA, Piccirilli JA. Synthetic antibodies for specific recognition and crystallization of structured RNA. Proceedings of the National Academy of Sciences of the United States of America. 105: 82-7. PMID 18162543 DOI: 10.1073/Pnas.0709082105  0.183
2020 Teyra J, Kelil A, Jain S, Helmy M, Jajodia R, Hooda Y, Gu J, D'Cruz AA, Nicholson SE, Min J, Sudol M, Kim PM, Bader GD, Sidhu SS. Large-scale survey and database of high affinity ligands for peptide recognition modules. Molecular Systems Biology. 16: e9310. PMID 33438817 DOI: 10.15252/msb.20199310  0.182
2014 Zhang W, Sidhu SS. Development of inhibitors in the ubiquitination cascade. Febs Letters. 588: 356-67. PMID 24239534 DOI: 10.1016/j.febslet.2013.11.003  0.182
2013 McLaughlin ME, Sidhu SS. Engineering and analysis of peptide-recognition domain specificities by phage display and deep sequencing Methods in Enzymology. 523: 327-349. PMID 23422437 DOI: 10.1016/B978-0-12-394292-0.00015-1  0.181
2016 Hershey DM, Browne PJ, Iavarone AT, Teyra J, Lee EH, Sidhu SS, Komeili A. Magnetite Biomineralization in Magnetospirillum magneticum is Regulated by a Switch-like Behavior in the HtrA Protease MamE. The Journal of Biological Chemistry. PMID 27302060 DOI: 10.1074/Jbc.M116.731000  0.179
2015 Laver JD, Li X, Ray D, Cook KB, Hahn NA, Nabeel-Shah S, Kekis M, Luo H, Marsolais AJ, Fung KY, Hughes TR, Westwood JT, Sidhu SS, Morris Q, Lipshitz HD, et al. Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition. Genome Biology. 16: 94. PMID 25962635 DOI: 10.1186/S13059-015-0659-4  0.178
2021 Novelli G, Liu J, Biancolella M, Alonzi T, Novelli A, Patten JJ, Cocciadiferro D, Agolini E, Colona VL, Rizzacasa B, Giannini R, Bigio B, Goletti D, Capobianchi MR, Grelli S, ... ... Sidhu SS, et al. Inhibition of HECT E3 ligases as potential therapy for COVID-19. Cell Death & Disease. 12: 310. PMID 33762578 DOI: 10.1038/s41419-021-03513-1  0.177
2019 Manczyk N, Veggiani G, Teyra J, Strilchuk AW, Sidhu SS, Sicheri F. The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency. Scientific Reports. 9: 4119. PMID 30858488 DOI: 10.1038/S41598-019-40815-Z  0.175
1996 Sidhu SS, Borgford TJ. Selection ofStreptomyces griseusProtease B Mutants With Desired Alterations in Primary Specificity Using a Library Screening Strategy Journal of Molecular Biology. 257: 233-245. PMID 8609620 DOI: 10.1006/Jmbi.1996.0159  0.175
2005 Pál G, Ultsch MH, Clark KP, Currell B, Kossiakoff AA, Sidhu SS. Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. Journal of Molecular Biology. 347: 489-94. PMID 15755445 DOI: 10.1016/J.Jmb.2005.01.040  0.174
2001 Sidhu SS. Engineering M13 for phage display. Biomolecular Engineering. 18: 57-63. PMID 11535417 DOI: 10.1016/S1389-0344(01)00087-9  0.173
2018 Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW. Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Molecular Cell. PMID 29656925 DOI: 10.1016/J.Molcel.2018.03.012  0.171
2012 Sidhu SS. Antibodies for all: The case for genome-wide affinity reagents. Febs Letters. 586: 2778-9. PMID 22664378 DOI: 10.1016/j.febslet.2012.05.044  0.171
2012 Mandal K, Uppalapati M, Ault-Riché D, Kenney J, Lowitz J, Sidhu SS, Kent SB. Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proceedings of the National Academy of Sciences of the United States of America. 109: 14779-84. PMID 22927390 DOI: 10.1073/Pnas.1210483109  0.17
2017 Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, ... ... Sidhu SS, et al. Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nature Biotechnology. PMID 29176614 DOI: 10.1038/Nbt.4021  0.17
2011 Qazi O, Rani M, Gnanam AJ, Cullen TW, Stead CM, Kensing H, McCaul K, Ngugi S, Prior JL, Lipka A, Nagy JM, Gregory CW, Judy BM, Harding SV, Titball RW, ... Sidhu SS, et al. Development of reagents and assays for the detection of pathogenic Burkholderia species. Faraday Discussions. 149: 23-36; discussion 63. PMID 21413172 DOI: 10.1039/C005422B  0.169
2007 Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. The Journal of Cell Biology. 178: 1265-78. PMID 17893247 DOI: 10.1083/Jcb.200705021  0.169
2015 Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC. Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity. Nature Immunology. PMID 26523866 DOI: 10.1038/Ni.3310  0.163
2018 Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, ... ... Sidhu SS, et al. Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature. 563: 559-563. PMID 30464266 DOI: 10.1038/S41586-018-0702-1  0.163
2021 Liang J, Ruthel G, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Jaladanki CK, Fan H, Freedman BD, Harty RN. Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress. Journal of Virology. PMID 33536174 DOI: 10.1128/JVI.00121-21  0.162
2015 Mattera R, Guardia CM, Sidhu S, Bonifacino JS. Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. The Journal of Biological Chemistry. PMID 26542808 DOI: 10.1074/Jbc.M115.683409  0.161
2019 Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. Optimization of peptidic HIV-1 fusion inhibitor T20 by phage display. Protein Science : a Publication of the Protein Society. PMID 31228294 DOI: 10.1002/pro.3669  0.16
1995 Sidhu SS, Kalmar GB, Willis LG, Borgford TJ. Protease evolution in Streptomyces griseus. Discovery of a novel dimeric enzymes. The Journal of Biological Chemistry. 270: 7594-600. PMID 7706307 DOI: 10.1074/Jbc.270.13.7594  0.159
2004 Held HA, Sidhu SS. Comprehensive mutational analysis of the M13 major coat protein: improved scaffolds for C-terminal phage display. Journal of Molecular Biology. 340: 587-97. PMID 15210356 DOI: 10.1016/J.JMB.2004.04.060  0.157
2023 Nabhan AN, Webster JD, Adams JJ, Blazer L, Everrett C, Eidenschenk C, Arlantico A, Fleming I, Brightbill HD, Wolters PJ, Modrusan Z, Seshagiri S, Angers S, Sidhu SS, Newton K, et al. Targeted alveolar regeneration with Frizzled-specific agonists. Cell. PMID 37321220 DOI: 10.1016/j.cell.2023.05.022  0.155
2014 Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Sidhu SS, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/Nature13430  0.153
2022 Hu S, Liu S, Bian Y, Poddar M, Singh S, Cao C, McGaughey J, Bell A, Blazer LL, Adams JJ, Sidhu SS, Angers S, Monga SP. Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b. Cell Reports. Medicine. 3: 100754. PMID 36220068 DOI: 10.1016/j.xcrm.2022.100754  0.153
2003 Weiss GA, Roth TA, Baldi PF, Sidhu SS. Comprehensive mutagenesis of the C-terminal domain of the M13 gene-3 minor coat protein: the requirements for assembly into the bacteriophage particle. Journal of Molecular Biology. 332: 777-82. PMID 12972250 DOI: 10.1016/S0022-2836(03)00950-1  0.153
2019 Lam AJ, MacDonald KN, Pesenacker AM, Juvet SC, Morishita KA, Bressler B, Pan JG, Sidhu SS, Rioux JD, Levings MK. Innate Control of Tissue-Reparative Human Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 30850479 DOI: 10.4049/Jimmunol.1801330  0.153
2016 Han Z, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 to Regulate Budding. Journal of Virology. PMID 27489272 DOI: 10.1128/Jvi.01078-16  0.153
2002 Roth TA, Weiss GA, Eigenbrot C, Sidhu SS. A minimized M13 coat protein defines the requirements for assembly into the bacteriophage particle. Journal of Molecular Biology. 322: 357-67. PMID 12217696 DOI: 10.1016/S0022-2836(02)00769-6  0.152
2001 Sidhu SS. Getting what you want from phage display Trends in Microbiology. 9: 565. DOI: 10.1016/S0966-842X(01)02206-5  0.152
2022 Sherpa D, Mueller J, Karayel Ö, Xu P, Yao Y, Chrustowicz J, Gottemukkala KV, Baumann C, Gross A, Czarnecki O, Zhang W, Gu J, Nilvebrant J, Sidhu SS, Murray PJ, et al. Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. Elife. 11. PMID 36459484 DOI: 10.7554/eLife.77937  0.15
2023 Alsaadi A, Artibani M, Hu Z, Wietek N, Morotti M, Gonzalez LS, Alazzam M, Jiang J, Abdul B, Soleymani Majd H, Blazer LL, Adams J, Silvestri F, Sidhu SS, Brugge JS, et al. Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids. Cell Reports. 42: 113354. PMID 37917586 DOI: 10.1016/j.celrep.2023.113354  0.15
2020 Liu S, Miersch S, Li P, Bai B, Liu C, Qin W, Su J, Huang H, Pan J, Sidhu SS, Wu D. A synthetic human antibody antagonizes IL-18Rβ signaling through an allosteric mechanism. Journal of Molecular Biology. PMID 31954129 DOI: 10.1016/j.jmb.2020.01.012  0.147
2016 Uppalapati M, Lee DJ, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riche D, Kent SB, Sidhu SS. A Potent D-protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable and Longer-Circulating In Vivo. Acs Chemical Biology. PMID 26745345 DOI: 10.1021/Acschembio.5B01006  0.147
2019 Stiffler MA, Poelwijk FJ, Brock KP, Stein RR, Riesselman A, Teyra J, Sidhu SS, Marks DS, Gauthier NP, Sander C. Protein Structure from Experimental Evolution. Cell Systems. PMID 31838147 DOI: 10.1016/J.Cels.2019.11.008  0.147
2023 Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications. 14: 7951. PMID 38040684 DOI: 10.1038/s41467-023-42706-4  0.145
2018 Veggiani G, Sidhu SS. Peptides meet ubiquitin: Simple interactions regulating complex cell signaling Peptide Science. 111: e24091. DOI: 10.1002/pep2.24091  0.145
2017 Rissland OS, Subtelny AO, Wang M, Lugowski A, Nicholson B, Laver JD, Sidhu SS, Smibert CA, Lipshitz HD, Bartel DP. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Genome Biology. 18: 211. PMID 29089021 DOI: 10.1186/S13059-017-1330-Z  0.144
2007 Sidhu SS, Feld BK, Weiss GA. M13 bacteriophage coat proteins engineered for improved phage display. Methods in Molecular Biology (Clifton, N.J.). 352: 205-19. PMID 17041267 DOI: 10.1385/1-59745-187-8:205  0.144
2009 Uysal S, Vásquez V, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A. Crystal structure of full-length KcsA in its closed conformation. Proceedings of the National Academy of Sciences of the United States of America. 106: 6644-9. PMID 19346472 DOI: 10.1073/Pnas.0810663106  0.142
2011 Koldobskaya Y, Duguid EM, Shechner DM, Suslov NB, Ye J, Sidhu SS, Bartel DP, Koide S, Kossiakoff AA, Piccirilli JA. A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nature Structural & Molecular Biology. 18: 100-6. PMID 21151117 DOI: 10.1038/Nsmb.1945  0.142
2020 Laver JD, Ly J, Winn AK, Karaiskakis A, Lin S, Nie K, Benic G, Jaberi-Lashkari N, Cao WX, Khademi A, Westwood JT, Sidhu SS, Morris Q, Angers S, Smibert CA, et al. The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs. Cell Reports. 30: 3353-3367.e7. PMID 32160542 DOI: 10.1016/J.Celrep.2020.02.066  0.141
2015 Barker SL, Pastor J, Carranza D, Quiñones H, Griffith C, Goetz R, Mohammadi M, Ye J, Zhang J, Hu MC, Kuro-o M, Moe OW, Sidhu SS. The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 30: 223-33. PMID 25324355 DOI: 10.1093/Ndt/Gfu291  0.138
2013 Sémiond D, Sidhu SS, Bissery MC, Vrignaud P. Can taxanes provide benefit in patients with CNS tumors and in pediatric patients with tumors? An update on the preclinical development of cabazitaxel. Cancer Chemotherapy and Pharmacology. 72: 515-28. PMID 23820961 DOI: 10.1007/s00280-013-2214-x  0.135
2016 Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA. Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Molecular Cell. PMID 27522463 DOI: 10.1016/J.Molcel.2016.07.003  0.134
2016 Arita Y, Allen S, Chen G, Zhang W, Wang Y, Owen AJ, Dentinger P, Sidhu SS. Rapid isolation of peptidic inhibitors of the solute carrier family transporters OATP1B1 and OATP1B3 by cell-based phage display selections. Biochemical and Biophysical Research Communications. PMID 26792727 DOI: 10.1016/j.bbrc.2016.01.050  0.133
2008 Barthelemy PA, Raab H, Appleton BA, Bond CJ, Wu P, Wiesmann C, Sidhu SS. Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. The Journal of Biological Chemistry. 283: 3639-54. PMID 18045863 DOI: 10.1074/Jbc.M708536200  0.132
2016 Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, ... ... Sidhu SS, et al. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165: 1440-1453. PMID 27259151 DOI: 10.1016/J.Cell.2016.05.037  0.13
2021 Phillips AT, Boumil EF, Castro N, Venkatesan A, Gallo E, Adams JJ, Sidhu SS, Bernstein AM. USP10 Promotes Fibronectin Recycling, Secretion, and Organization. Investigative Ophthalmology & Visual Science. 62: 15. PMID 34665194 DOI: 10.1167/iovs.62.13.15  0.128
2015 Boyle AJ, Cao PJ, Hedley DW, Sidhu SS, Winnik MA, Reilly RM. MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using (64)Cu-NOTA-panitumumab F(ab')2 fragments. Nuclear Medicine and Biology. 42: 71-7. PMID 25456837 DOI: 10.1016/J.Nucmedbio.2014.10.009  0.126
2014 Boyle AJ, Hedley DW, Sidhu SS, Winnik MA, Reilly RM. Abstract 103: 64-Cu-NOTA-panitumumab F(ab')2 fragments for PET/CT imaging of pancreatic cancer Cancer Research. 74: 103-103. DOI: 10.1158/1538-7445.Am2014-103  0.125
2016 Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. The Embo Journal. PMID 28028054 DOI: 10.15252/Embj.201695063  0.121
2014 Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, ... ... Sidhu SS, et al. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nature Structural & Molecular Biology. 21: 686-95. PMID 24997600 DOI: 10.1038/Nsmb.2853  0.12
2015 Hu MC, Shi M, Zhang J, Addo T, Cho HJ, Barker SL, Ravikumar P, Gillings N, Bian A, Sidhu SS, Kuro-O M, Moe OW. Renal Production, Uptake, and Handling of Circulating αKlotho. Journal of the American Society of Nephrology : Jasn. PMID 25977312 DOI: 10.1681/Asn.2014101030  0.119
2020 Yuan X, Garg S, Haan K, Fellouse FA, Gopalsamy A, Tykvart J, Sidhu SS, Varma MM, Pal P, Hillan EM, Dou JJ, Aitchison JS. Bead-based multiplex detection of dengue biomarkers in a portable imaging device. Biomedical Optics Express. 11: 6154-6167. PMID 33282481 DOI: 10.1364/BOE.403803  0.115
2016 Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, ... ... Sidhu SS, et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nature Cell Biology. PMID 27323329 DOI: 10.1038/Ncb3376  0.115
2018 Lam AJ, Huang H, Pan JG, Sidhu SS, Charron G, Ivison SM, Rioux JD, Levings MK. Human Regulatory T Cell Potential for Tissue Repair Via IL-33/ST2 and Amphiregulin Transplantation. 102. DOI: 10.1097/01.Tp.0000543061.12872.C0  0.115
2003 Sidhu SS, Fairbrother WJ, Deshayes K. Exploring Protein—Protein Interactions with Phage Display Cheminform. 34. DOI: 10.1002/CHIN.200310279  0.103
2022 Bhardwaj A, Banh RS, Zhang W, Sidhu SS, Neel BG. MMD-associated SNPs encode dominant-negative alleles that globally impair ubiquitylation. Life Science Alliance. 5. PMID 35135845 DOI: 10.26508/lsa.202000807  0.103
2017 Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN. Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. Plos Pathogens. 13: e1006519. PMID 28723972 DOI: 10.1371/Journal.Ppat.1006519  0.102
2017 Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC. Effects of Erythropoietin Receptor Activity on Angiogenesis, Tubular Injury and Fibrosis in Acute Kidney Injury: A "U-Shaped" Relationship. American Journal of Physiology. Renal Physiology. ajprenal.00306.2017. PMID 29187371 DOI: 10.1152/ajprenal.00306.2017  0.081
2011 Bahudhanapati H, Zhang Y, Sidhu SS, Brew K. Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1)). The Journal of Biological Chemistry. 286: 31761-70. PMID 21715326 DOI: 10.1074/Jbc.M111.253328  0.081
1993 Sidhu SS, Kalmar GB, Borgford TJ. Characterization of the gene encoding the glutamic-acid-specific protease of Streptomyces griseus. Biochemistry and Cell Biology. 71: 454-461. PMID 7910748 DOI: 10.1139/O93-067  0.08
2008 YEH J, Sidhu SS, Chan AC. Crtam regulates a late phase of T cell polarity and IFNγ/IL22 cytokine production The Faseb Journal. 22: 384-384. DOI: 10.1096/FASEBJ.22.2_SUPPLEMENT.384  0.073
2018 Gorelik M, Sidhu SS. Regulation of SCF E3 ligase activity by Cand1 Biotarget. 2: 10-10. DOI: 10.21037/biotarget.2018.05.03  0.07
2020 Neyra JA, Moe OW, Pastor J, Gianella F, Sidhu SS, Sarnak MJ, Ix JH, Drew DA. Performance of soluble Klotho assays in clinical samples of kidney disease. Clinical Kidney Journal. 13: 235-244. PMID 32297879 DOI: 10.1093/ckj/sfz085  0.065
2013 Miersch S, Sidhu SS. Immunology: Evolving superkines for selectivity. Nature Chemical Biology. 8: 955-6. PMID 23183579 DOI: 10.1038/nchembio.1119  0.065
2013 Ernst A, Sidhu SS. Engineering ubiquitin to modulate the ubiquitin proteosome system. Cell Cycle (Georgetown, Tex.). 12: 1651-2. PMID 23673323 DOI: 10.4161/cc.24985  0.059
2018 Zhang W, Sidhu SS. Drug development: Allosteric inhibitors hit USP7 hard. Nature Chemical Biology. 14: 110-111. PMID 29337966 DOI: 10.1038/nchembio.2557  0.058
2019 Sidhu SS. Phage display: increasing the rewards from genomic information. Drug Discovery Today. 6: 936. PMID 11546606 DOI: 10.1016/S1359-6446(01)01970-5  0.052
2009 Sidhu SS, VanHook AM. Science Signaling Podcast: 8 September 2009 Science Signaling. 2. DOI: 10.1126/Scisignal.287Pc16  0.041
2023 Brandimarte B, Di Rienzo Businco L, Cappello F, Fiore R, Bastone G, Gualdi G, Sollaku S, Casciani E, Tortorella F, Longo P, Centanini E, Pavaci S, Sangiuolo F, Patrizi MP, Miersch S, ... Sidhu SS, et al. Nebulization of pharmacological solutions with an innovative medical device based on microvaporization. Heliyon. 9: e14673. PMID 37020941 DOI: 10.1016/j.heliyon.2023.e14673  0.039
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