133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053  0.367
2020 Royea J, Lacalle-Aurioles M, Trigiani LJ, Fermigier A, Hamel E. AT2R's (Angiotensin II Type 2 Receptor's) Role in Cognitive and Cerebrovascular Deficits in a Mouse Model of Alzheimer Disease. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11914. PMID 32362228 DOI: 10.1161/Hypertensionaha.119.14431  0.374
2020 Trigiani LJ, Lacalle-Aurioles M, Bourourou M, Li L, Greenhalgh AD, Zarruk JG, David S, Fehlings MG, Hamel E. Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia. Glia. PMID 32154952 DOI: 10.1002/Glia.23815  0.335
2019 Royea J, Martinot P, Hamel E. Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease. Neurobiology of Disease. 134: 104644. PMID 31669735 DOI: 10.1016/J.Nbd.2019.104644  0.399
2019 Trigiani LJ, Royea J, Tong XK, Hamel E. Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901002R. PMID 31557051 DOI: 10.1096/Fj.201901002R  0.322
2019 Wong EW, Glasgow SD, Trigiani LJ, Chitsaz D, Rymar V, Sadikot A, Ruthazer ES, Hamel E, Kennedy TE. Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain. Learning & Memory (Cold Spring Harbor, N.Y.). 26: 77-83. PMID 30770464 DOI: 10.1101/Lm.049072.118  0.325
2019 Lecrux C, Bourourou M, Hamel E. How reliable is cerebral blood flow to map changes in neuronal activity? Autonomic Neuroscience : Basic & Clinical. 217: 71-79. PMID 30744905 DOI: 10.1016/J.Autneu.2019.01.005  0.348
2019 Tong XK, Trigiani LJ, Hamel E. High cholesterol triggers white matter alterations and cognitive deficits in a mouse model of cerebrovascular disease: benefits of simvastatin. Cell Death & Disease. 10: 89. PMID 30692517 DOI: 10.1038/S41419-018-1199-0  0.346
2019 Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, ... ... Hamel E, et al. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 158-167. PMID 30642436 DOI: 10.1016/J.Jalz.2018.07.222  0.357
2018 Trigiani LJ, Royea J, Lacalle-Aurioles M, Tong XK, Hamel E. Pleiotropic Benefits of the Angiotensin Receptor Blocker Candesartan in a Mouse Model of Alzheimer Disease. Hypertension (Dallas, Tex. : 1979). 72: 1217-1226. PMID 30354809 DOI: 10.1161/Hypertensionaha.118.11775  0.404
2018 Cauli B, Hamel E. Brain Perfusion and Astrocytes. Trends in Neurosciences. 41: 409-413. PMID 29933772 DOI: 10.1016/J.Tins.2018.04.010  0.322
2017 Trigiani LJ, Hamel E. An endothelial link between the benefits of physical exercise in dementia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17714655. PMID 28617071 DOI: 10.1177/0271678X17714655  0.329
2017 Royea J, Zhang L, Tong XK, Hamel E. Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28476949 DOI: 10.1523/Jneurosci.0329-17.2017  0.413
2017 Pakavathkumar P, Noël A, Lecrux C, Tubeleviciute-Aydin A, Hamel E, Ahlfors JE, LeBlanc AC. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Molecular Neurodegeneration. 12: 22. PMID 28241839 DOI: 10.1186/S13024-017-0166-Z  0.309
2017 Naito Y, Tanabe Y, Lee AK, Hamel E, Takahashi H. Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization. Scientific Reports. 7: 42548. PMID 28211900 DOI: 10.1038/Srep42548  0.316
2017 Lecrux C, Sandoe CH, Neupane S, Kropf P, Toussay X, Tong XK, Lacalle-Aurioles M, Shmuel A, Hamel E. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28069927 DOI: 10.1523/Jneurosci.1784-16.2016  0.388
2017 Hamel E. Animal Models: Vascular Models of Cognitive Dysfunction Primer On Cerebrovascular Diseases. 315-319. DOI: 10.1016/B978-0-12-803058-5.00066-7  0.364
2016 Lecrux C, Hamel E. Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states. Philosophical Transactions of the Royal Society B. 371: 20150350. PMID 27574304 DOI: 10.1098/Rstb.2015.0350  0.363
2016 Papadopoulos P, Tong XK, Imboden H, Hamel E. Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27389178 DOI: 10.1177/0271678X16658489  0.388
2016 Badhwar A, Brown R, Stanimirovic DB, Haqqani AS, Hamel E. Proteomic differences in brain vessels of Alzheimer's disease mice: Normalization by PPARγ agonist pioglitazone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27339263 DOI: 10.1177/0271678X16655172  0.37
2016 Hamel E, Royea J, Ongali B, Tong XK. Neurovascular and Cognitive failure in Alzheimer's Disease: Benefits of Cardiovascular Therapy. Cellular and Molecular Neurobiology. PMID 26993506 DOI: 10.1007/S10571-015-0285-4  0.369
2016 Ongali B, Nicolakakis N, Tong XK, Aboulkassim T, Imboden H, Hamel E. Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26923013 DOI: 10.3233/Jad-150868  0.406
2015 Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, ... ... Hamel E, et al. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. The Journal of Experimental Medicine. 212: 1529-49. PMID 26347470 DOI: 10.1084/Jem.20150165  0.313
2015 Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EM, Tegeder I, Murphy TH, Hamel E, Cauli B. COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11791-810. PMID 26311764 DOI: 10.1523/Jneurosci.0651-15.2015  0.387
2015 Martins C, H?lková H, Dridi L, Dormoy-Raclet V, Grigoryeva L, Choi Y, Langford-Smith A, Wilkinson FL, Ohmi K, DiCristo G, Hamel E, Ausseil J, Cheillan D, Moreau A, Svobodová E, et al. Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model. Brain : a Journal of Neurology. 138: 336-55. PMID 25567323 DOI: 10.1093/Brain/Awu355  0.344
2015 Tong XK, Hamel E. Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 512-20. PMID 25564230 DOI: 10.1038/Jcbfm.2014.226  0.375
2015 Hamel E. Cerebral circulation: function and dysfunction in Alzheimer's disease. Journal of Cardiovascular Pharmacology. 65: 317-24. PMID 25384195 DOI: 10.1097/Fjc.0000000000000177  0.332
2015 Hamel E. Basic concepts of neuronal control of cerebral blood flow in health and disease Autonomic Neuroscience: Basic and Clinical. 192: 28. DOI: 10.1016/J.Autneu.2015.07.337  0.307
2014 Gupta A, Lacoste B, Pistell PJ, Pistel PJ, Ingram DK, Hamel E, Alaoui-Jamali MA, Szarek WA, Vlahakis JZ, Jie S, Song W, Schipper HM. Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease. Journal of Neurochemistry. 131: 778-90. PMID 25111043 DOI: 10.1111/Jnc.12927  0.64
2014 Ongali B, Nicolakakis N, Tong XK, Aboulkassim T, Papadopoulos P, Rosa-Neto P, Lecrux C, Imboden H, Hamel E. Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model. Neurobiology of Disease. 68: 126-36. PMID 24807206 DOI: 10.1016/J.Nbd.2014.04.018  0.401
2014 Badhwar A, Stanimirovic DB, Hamel E, Haqqani AS. The proteome of mouse cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1033-46. PMID 24667914 DOI: 10.1038/Jcbfm.2014.52  0.31
2014 LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. Cell Death and Differentiation. 21: 696-706. PMID 24413155 DOI: 10.1038/Cdd.2013.194  0.314
2014 Papadopoulos P, Tong XK, Hamel E. Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice. Neurobiology of Aging. 35: 203-12. PMID 23954171 DOI: 10.1016/J.Neurobiolaging.2013.07.010  0.366
2013 Badhwar A, Lerch JP, Hamel E, Sled JG. Impaired structural correlates of memory in Alzheimer's disease mice. Neuroimage. Clinical. 3: 290-300. PMID 24273714 DOI: 10.1016/J.Nicl.2013.08.017  0.338
2013 Zhang L, Papadopoulos P, Hamel E. Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease. British Journal of Pharmacology. 170: 661-70. PMID 23889563 DOI: 10.1111/Bph.12315  0.359
2013 Papadopoulos P, Rosa-Neto P, Rochford J, Hamel E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology. Plos One. 8: e68612. PMID 23874687 DOI: 10.1371/Journal.Pone.0068612  0.404
2013 Lacoste B, Tong XK, Lahjouji K, Couture R, Hamel E. Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice. Journal of Neuroinflammation. 10: 57. PMID 23642031 DOI: 10.1186/1742-2094-10-57  0.684
2013 Grand'maison M, Zehntner SP, Ho MK, Hébert F, Wood A, Carbonell F, Zijdenbos AP, Hamel E, Bedell BJ. Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease. Neurobiology of Disease. 54: 59-67. PMID 23454197 DOI: 10.1016/J.Nbd.2013.02.005  0.356
2013 Toussay X, Basu K, Lacoste B, Hamel E. Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3390-401. PMID 23426667 DOI: 10.1523/Jneurosci.3346-12.2013  0.649
2013 Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, et al. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Reports. 3: 173-85. PMID 23291093 DOI: 10.1016/J.Celrep.2012.12.005  0.325
2013 Hébert F, Grand'maison M, Ho MK, Lerch JP, Hamel E, Bedell BJ. Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer's disease. Neurobiology of Aging. 34: 1644-52. PMID 23273599 DOI: 10.1016/J.Neurobiolaging.2012.11.022  0.358
2012 Song W, Zukor H, Lin SH, Hascalovici J, Liberman A, Tavitian A, Mui J, Vali H, Tong XK, Bhardwaj SK, Srivastava LK, Hamel E, Schipper HM. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10841-53. PMID 22875919 DOI: 10.1523/Jneurosci.6469-11.2012  0.334
2012 Tong XK, Lecrux C, Rosa-Neto P, Hamel E. Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4705-15. PMID 22492027 DOI: 10.1523/Jneurosci.0169-12.2012  0.404
2012 Lecrux C, Kocharyan A, Sandoe CH, Tong XK, Hamel E. Pyramidal cells and cytochrome P450 epoxygenase products in the neurovascular coupling response to basal forebrain cholinergic input. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 896-906. PMID 22293985 DOI: 10.1038/Jcbfm.2012.4  0.368
2012 Badhwar A, Stanimirovic D, Haqqani A, Hamel E. P4-041: Quantitative proteomics of Alzheimer's-like cerebral vasculature in TGF-ß1 overexpressing mice and its perturbation by pioglitazone Alzheimer's & Dementia. 8: P650-P650. DOI: 10.1016/J.Jalz.2012.05.1742  0.348
2012 Badhwar A, Brown R, Delaney C, Stanimirovic D, Haqqani A, Hamel E. P3-332: Rescue of beta-amyloid-induced alterations in cerebrovascular protein expression by pioglitazone in APP mice: Link to functional recovery in the cerebrovasculature Alzheimer's & Dementia. 8: P574-P575. DOI: 10.1016/J.Jalz.2012.05.1556  0.312
2011 Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Lévesque M, Plaisier F, Shmuel A, Cauli B, Hamel E. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9836-47. PMID 21734275 DOI: 10.1523/Jneurosci.4943-10.2011  0.362
2011 Aboulkassim T, Tong XK, Tse YC, Wong TP, Woo SB, Neet KE, Brahimi F, Hamel E, Saragovi HU. Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory. Molecular Pharmacology. 80: 498-508. PMID 21616921 DOI: 10.1124/Mol.111.071332  0.339
2011 Nicolakakis N, Hamel E. Neurovascular function in Alzheimer's disease patients and experimental models. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1354-70. PMID 21468088 DOI: 10.1038/Jcbfm.2011.43  0.376
2011 Lecrux C, Hamel E. The neurovascular unit in brain function and disease. Acta Physiologica (Oxford, England). 203: 47-59. PMID 21272266 DOI: 10.1111/J.1748-1716.2011.02256.X  0.345
2011 Drouin A, Bolduc V, Thorin-Trescases N, Bélanger É, Fernandes P, Baraghis E, Lesage F, Gillis MA, Villeneuve L, Hamel E, Ferland G, Thorin E. Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1032-43. PMID 21186270 DOI: 10.1152/Ajpheart.00410.2010  0.35
2011 Nicolakakis N, Aboulkassim T, Aliaga A, Tong XK, Rosa-Neto P, Hamel E. Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 200-11. PMID 20571524 DOI: 10.1038/Jcbfm.2010.78  0.356
2011 Hebert F, Ho M, Lerch J, Hamel E, Bedell B. P4-356: MRI-derived cortical thickness measurements from APP transgenic mice Alzheimer's & Dementia. 7: e36-e36. DOI: 10.1016/J.Jalz.2011.09.101  0.304
2011 Lacoste B, Tong X, Lahjouji K, Couture R, Hamel E. O3-07-02: Bradykinin B1 receptor blockade in the treatment of Alzheimer's disease: improvement of cognitive and cerebrovascular functions and reduction of amyloidosis Alzheimer's & Dementia. 7: S512-S513. DOI: 10.1016/J.Jalz.2011.05.1433  0.622
2010 Ongali B, Nicolakakis N, Lecrux C, Aboulkassim T, Rosa-Neto P, Papadopoulos P, Tong XK, Hamel E. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. The American Journal of Pathology. 177: 3071-80. PMID 21088218 DOI: 10.2353/Ajpath.2010.100339  0.392
2010 Seyrantepe V, Lema P, Caqueret A, Dridi L, Bel Hadj S, Carpentier S, Boucher F, Levade T, Carmant L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud JL, Morales CR, et al. Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. Plos Genetics. 6: e1001118. PMID 20862357 DOI: 10.1371/Journal.Pgen.1001118  0.338
2010 Nicolakakis N, Hamel E. The Nuclear Receptor PPARgamma as a Therapeutic Target for Cerebrovascular and Brain Dysfunction in Alzheimer's Disease. Frontiers in Aging Neuroscience. 2. PMID 20725514 DOI: 10.3389/Fnagi.2010.00021  0.382
2010 Cauli B, Hamel E. Revisiting the role of neurons in neurovascular coupling. Frontiers in Neuroenergetics. 2: 9. PMID 20616884 DOI: 10.3389/Fnene.2010.00009  0.335
2009 Saragovi HU, Hamel E, Di Polo A. A neurotrophic rationale for the therapy of neurodegenerative disorders. Current Alzheimer Research. 6: 419-23. PMID 19874265 DOI: 10.2174/156720509789207912  0.31
2009 Tong XK, Nicolakakis N, Fernandes P, Ongali B, Brouillette J, Quirion R, Hamel E. Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice. Neurobiology of Disease. 35: 406-14. PMID 19524673 DOI: 10.1016/J.Nbd.2009.06.003  0.397
2009 Enager P, Piilgaard H, Offenhauser N, Kocharyan A, Fernandes P, Hamel E, Lauritzen M. Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 976-86. PMID 19337274 DOI: 10.1038/Jcbfm.2009.23  0.37
2009 Badhwar A, Chakravarty M, Zehntner S, Hamel E, Bedell B. Automated quantification of vascular and parenchymal beta-amyloid burdens in a transgenic mouse model of Alzheimer's disease Journal of the Neurological Sciences. 283: 253. DOI: 10.1016/J.Jns.2009.02.058  0.321
2009 Ongali B, Nicolakakis N, Lecrux C, Aboulkassim T, Fernandes P, Tong X, Hamel E. P4-043: Cerebrovascular and memory deficits in an Alzheimer's disease mouse model overexpressing amyloid precursor protein and transforming growth factor-β1 Alzheimer's & Dementia. 5: P444-P444. DOI: 10.1016/J.Jalz.2009.04.913  0.302
2008 Nicolakakis N, Aboulkassim T, Ongali B, Lecrux C, Fernandes P, Rosa-Neto P, Tong XK, Hamel E. Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9287-96. PMID 18784309 DOI: 10.1523/Jneurosci.3348-08.2008  0.445
2008 Sakai Y, Dobson C, Diksic M, Aubé M, Hamel E. Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis Neurology. 70: 431-439. PMID 18250288 DOI: 10.1212/01.Wnl.0000299095.65331.6F  0.31
2008 Kocharyan A, Fernandes P, Tong XK, Vaucher E, Hamel E. Specific subtypes of cortical GABA interneurons contribute to the neurovascular coupling response to basal forebrain stimulation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 221-31. PMID 17895909 DOI: 10.1038/Sj.Jcbfm.9600558  0.336
2007 Tong XK, Hamel E. Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase. Molecular Pharmacology. 72: 1476-83. PMID 17848599 DOI: 10.1124/Mol.107.039602  0.378
2007 Drouin A, Thorin-Trescases N, Hamel E, Falck JR, Thorin E. Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries. Cardiovascular Research. 73: 73-81. PMID 17113574 DOI: 10.1016/J.Cardiores.2006.10.005  0.323
2006 Rancillac A, Rossier J, Guille M, Tong XK, Geoffroy H, Amatore C, Arbault S, Hamel E, Cauli B. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6997-7006. PMID 16807329 DOI: 10.1523/Jneurosci.5515-05.2006  0.385
2006 Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. Journal of Applied Physiology (Bethesda, Md. : 1985). 100: 1059-64. PMID 16467392 DOI: 10.1152/Japplphysiol.00954.2005  0.341
2006 Choi JK, Chen YI, Hamel E, Jenkins BG. Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage. 30: 700-12. PMID 16459104 DOI: 10.1016/J.Neuroimage.2005.10.029  0.307
2005 Tong XK, Nicolakakis N, Kocharyan A, Hamel E. Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11165-74. PMID 16319316 DOI: 10.1523/Jneurosci.4031-05.2005  0.396
2005 Aucoin JS, Jiang P, Aznavour N, Tong XK, Buttini M, Descarries L, Hamel E. Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease. Neuroscience. 132: 73-86. PMID 15780468 DOI: 10.1016/J.Neuroscience.2004.11.047  0.619
2005 Descarries L, Aznavour N, Hamel E. The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPP(SW,IND) mouse model of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 149-62. PMID 15599613 DOI: 10.1007/S00702-004-0186-Z  0.62
2005 Tong X, Nicolakakis N, Hamel E. Vascular fibrosis versus amyloid beta (A|[szlig]|)-induced oxidative stress in the cerebrovascular pathology associated with Alzheimer|[rsquo]|s disease (AD) Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0173  0.328
2005 Kocharyan A, Fernandes P, Serluca N, Vaucher E, Hamel E. Chemical or electrical stimulation of basal forebrain neurons activates specific subsets of cortical GABA-interneurons in parallel with increases in cortical cerebral blood flow Journal of Cerebral Blood Flow & Metabolism. 25: S159-S159. DOI: 10.1038/Sj.Jcbfm.9591524.0159  0.339
2005 Nicolakakis N, Tong X, Hamel E. Reversal of fully developed cerebrovascular dysfunctions in two transgenic mouse models of Alzheimer's disease Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0157  0.321
2004 Cauli B, Tong XK, Rancillac A, Serluca N, Lambolez B, Rossier J, Hamel E. Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8940-9. PMID 15483113 DOI: 10.1523/Jneurosci.3065-04.2004  0.388
2004 Dobson C, Tohyama Y, Diksic M, Hamel E. Effects of acute or chronic administration of anti‐migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain Cephalalgia. 24: 2-11. PMID 14687006 DOI: 10.1111/J.1468-2982.2004.00647.X  0.312
2004 Hamel E. Cholinergic modulation of the cortical microvascular bed. Progress in Brain Research. 145: 171-8. PMID 14650915 DOI: 10.1016/S0079-6123(03)45012-7  0.377
2002 Férézou I, Cauli B, Hill EL, Rossier J, Hamel E, Lambolez B. 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7389-97. PMID 12196560 DOI: 10.1523/Jneurosci.22-17-07389.2002  0.365
2002 Moreno MJ, Abounader R, Hébert E, Doods H, Hamel E. Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment. Neuropharmacology. 42: 568-76. PMID 11955527 DOI: 10.1016/S0028-3908(02)00008-4  0.347
2002 Moreno MJ, Terrón JA, Stanimirovic DB, Doods H, Hamel E. Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture. Neuropharmacology. 42: 270-80. PMID 11804624 DOI: 10.1016/S0028-3908(01)00176-9  0.331
2001 Elhusseiny A, Hamel E. Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles British Journal of Pharmacology. 132: 55-62. PMID 11156561 DOI: 10.1038/Sj.Bjp.0703763  0.356
2000 Vaucher E, Tong XK, Cholet N, Lantin S, Hamel E. GABA neurons provide a rich input to microvessels but not nitric oxide neurons in the rat cerebral cortex: a means for direct regulation of local cerebral blood flow. The Journal of Comparative Neurology. 421: 161-71. PMID 10813779 DOI: 10.1002/(Sici)1096-9861(20000529)421:2<161::Aid-Cne3>3.0.Co;2-F  0.367
2000 Tomita M, Suzuki N, Hamel E, Busija D, Lauritzen M. Regulation of cerebral microcirculation--update. The Keio Journal of Medicine. 49: 26-34. PMID 10750378 DOI: 10.2302/Kjm.49.26  0.381
2000 Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R. BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. British Journal of Pharmacology. 129: 1075-88. PMID 10725255 DOI: 10.1038/Sj.Bjp.0703162  0.327
2000 Bouchelet I, Case B, Olivier A, Hamel E. No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries: similarity with human coronary artery. British Journal of Pharmacology. 129: 501-508. PMID 10711348 DOI: 10.1038/Sj.Bjp.0703081  0.321
2000 Ishine T, Bouchelet I, Hamel E, Lee TJF. Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins American Journal of Physiology-Heart and Circulatory Physiology. 278. PMID 10710360 DOI: 10.1152/Ajpheart.2000.278.3.H907  0.304
2000 Elhusseiny A, Hamel E. Muscarinic—but Not Nicotinic—Acetylcholine Receptors Mediate a Nitric Oxide-Dependent Dilation in Brain Cortical Arterioles: A Possible Role for the M5 Receptor Subtype Journal of Cerebral Blood Flow and Metabolism. 20: 298-305. PMID 10698067 DOI: 10.1097/00004647-200002000-00011  0.311
1999 Moreno MJ, Cohen Z, Stanimirovic DB, Hamel E. Functional calcitonin gene-related peptide type 1 and adrenomedullin receptors in human trigeminal ganglia, brain vessels, and cerebromicrovascular or astroglial cells in culture. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 1270-8. PMID 10566974 DOI: 10.1097/00004647-199911000-00012  0.353
1999 Hamel E. The biology of serotonin receptors: focus on migraine pathophysiology and treatment. Canadian Journal of Neurological Sciences. 26: 2-6. PMID 10563226 DOI: 10.1017/S0317167100000123  0.32
1999 Cohen Z, Bouchelet I, Olivier A, Villemure JG, Ball R, Stanimirovic DB, Hamel E. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 908-17. PMID 10458598 DOI: 10.1097/00004647-199908000-00010  0.37
1999 Elhusseiny A, Cohen Z, Olivier A, Stanimirović DB, Hamel E. Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 794-802. PMID 10413035 DOI: 10.1097/00004647-199907000-00010  0.354
1999 Tong XK, Hamel E. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience. 92: 163-175. PMID 10392839 DOI: 10.1016/S0306-4522(98)00750-7  0.423
1999 Ljubic‐Thibal V, Morin A, Diksic M, Hamel E. Origin of the serotonergic innervation to the rat dorsolateral hypothalamus: retrograde transport of cholera toxin and upregulation of tryptophan hydroxylase mRNA expression following selective nerve terminals lesion. Synapse. 32: 177-186. PMID 10340628 DOI: 10.1002/(Sici)1098-2396(19990601)32:3<177::Aid-Syn4>3.0.Co;2-D  0.338
1999 Abounader R, Elhusseiny A, Cohen Z, Olivier A, Stanimirovic D, Quirion R, Hamel E. Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 155-63. PMID 10027771 DOI: 10.1097/00004647-199902000-00007  0.326
1998 Riad M, Tong XK, el Mestikawy S, Hamon M, Hamel E, Descarries L. Endothelial expression of the 5-hydroxytryptamine1B antimigraine drug receptor in rat and human brain microvessels. Neuroscience. 86: 1031-5. PMID 9697110 DOI: 10.1016/S0306-4522(98)00196-1  0.615
1998 St-Pierre JA, Dumont Y, Nouel D, Herzog H, Hamel E, Quirion R. Preferential expression of the neuropeptide Y Y1 over the Y2 receptor subtype in cultured hippocampal neurons and cloning of the rat Y2 receptor. British Journal of Pharmacology. 123: 183-94. PMID 9489605 DOI: 10.1038/Sj.Bjp.0701589  0.344
1998 Petty MA, Elands J, Johnson MP, Linnik MD, Hamel E, Moskowitz MA, Lee WS, McCarty DR, Hibert M, Baron BM. The selectivity of MDL 74,721 in models of neurogenic versus vascular components of migraine. European Journal of Pharmacology. 336: 127-36. PMID 9384224 DOI: 10.1016/S0014-2999(97)01218-1  0.355
1997 Abounader R, Hamel E. Associations between neuropeptide Y nerve terminals and intraparenchymal microvessels in rat and human cerebral cortex The Journal of Comparative Neurology. 388: 444-453. PMID 9368852 DOI: 10.1002/(Sici)1096-9861(19971124)388:3<444::Aid-Cne7>3.0.Co;2-0  0.389
1997 Cohen Z, Molinatti G, Hamel E. Astroglial and Vascular Interactions of Noradrenaline Terminals in the Rat Cerebral Cortex Journal of Cerebral Blood Flow and Metabolism. 17: 894-904. PMID 9290587 DOI: 10.1097/00004647-199708000-00008  0.352
1997 Vaucher E, Linville D, Hamel E. Cholinergic basal forebrain projections to nitric oxide synthase- containing neurons in the rat cerebral cortex Neuroscience. 79: 827-836. PMID 9219945 DOI: 10.1016/S0306-4522(97)00033-X  0.357
1997 Linville DG, Hamel E. Acetylcholine and Its Receptors Primer On Cerebrovascular Diseases. 82-85. DOI: 10.1016/B978-012743170-3.50024-8  0.412
1996 Cohen Z, Bonvento G, Lacombe P, Hamel E. Serotonin In The Regulation Of Brain Microcirculation Progress in Neurobiology. 50: 335-362. PMID 9004349 DOI: 10.1016/S0301-0082(96)00033-0  0.365
1996 Ljubić-Thibal V, Diksic M, Hamel E, Raison S, Pujol JF, Weissmann D. Ipsilateral alterations in tryptophan hydroxylase activity in rat brain after hypothalamic 5,7-di-hydroxytryptamine lesion. Brain Research. 724: 222-31. PMID 8828572 DOI: 10.1016/0006-8993(96)00327-7  0.304
1995 Abounader R, Villemure J, Hamel E. Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226. British Journal of Pharmacology. 116: 2245-2250. PMID 8564255 DOI: 10.1111/J.1476-5381.1995.Tb15060.X  0.352
1995 Cohen Z, Tsuiki K, Takada A, Beaudet A, Diksic M, Hamel E. In vivo-synthesized radioactively labelled α-methyl serotonin as a selective tracer for visualization of brain serotonin neurons Synapse. 21: 21-28. PMID 8525458 DOI: 10.1002/Syn.890210104  0.318
1995 Linville DG, Hamel E. Pharmacological characterization of muscarinic acetylcholine binding sites in human and bovine cerebral microvessels Naunyn-Schmiedeberg's Archives of Pharmacology. 352: 179-186. PMID 7477441 DOI: 10.1007/Bf00176772  0.316
1995 Vaucher E, Hamel E. Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry The Journal of Neuroscience. 15: 7427-7441. DOI: 10.1523/Jneurosci.15-11-07427.1995  0.349
1994 Chédotal A, Cozzari C, Faure MP, Hartman BK, Hamel E. Distinct choline acetyltransferase (ChAT) and vasoactive intestinal polypeptide (VIP) bipolar neurons project to local blood vessels in the rat cerebral cortex. Brain Research. 646: 181-93. PMID 8069662 DOI: 10.1016/0006-8993(94)90076-0  0.621
1994 Dauphin F, Linville DG, Hamel E. Cholinergic dilatation and constriction of feline cerebral blood vessels are mediated by stimulation of phosphoinositide metabolism via two different muscarinic receptor subtypes. Journal of Neurochemistry. 63: 544-51. PMID 8035178 DOI: 10.1046/J.1471-4159.1994.63020544.X  0.347
1994 Chédotal A, Umbriaco D, Descarries L, Hartman BK, Hamel E. Light and electron microscopic immunocytochemical analysis of the neurovascular relationships of choline acetyltransferase and vasoactive intestinal polypeptide nerve terminals in the rat cerebral cortex. The Journal of Comparative Neurology. 343: 57-71. PMID 8027437 DOI: 10.1002/Cne.903430105  0.705
1993 Hamel E, Grégoire L, Lau B. 5-HT1 receptors mediating contraction in bovine cerebral arteries: a model for human cerebrovascular '5-HT1Dβ' receptors European Journal of Pharmacology. 242: 75-82. PMID 8223939 DOI: 10.1016/0014-2999(93)90012-7  0.327
1993 Cossette P, Umbriaco D, Zamar N, Hamel E, Descarries L. Recovery of choline acetyltransferase activity without sprouting of the residual acetylcholine innervation in adult rat cerebral cortex after lesion of the nucleus basalis. Brain Research. 630: 195-206. PMID 8118686 DOI: 10.1016/0006-8993(93)90657-9  0.584
1993 Hasséssian H, Poulat P, Hamel E, Reader TA, Couture R. Spinal cord serotonin receptors in cardiovascular regulation and potentiation of the pressor response to intrathecal substance P after serotonin depletion. Canadian Journal of Physiology and Pharmacology. 71: 453-64. PMID 7694781 DOI: 10.1139/Y93-067  0.303
1992 Cohen Z, Bovento G, Lacombe P, Seylaz J, MacKenzie ET, Hamel E. Cerebrovascular nerve fibers immunoreactive for tryptophan-5-hydroxylase in the rat: distribution, putative origin and comparison with sympathetic noradrenergic nerves. Brain Research. 598: 203-14. PMID 1486481 DOI: 10.1016/0006-8993(92)90184-B  0.321
1992 Giguère JF, Hamel E, Butterworth RF. Increased densities of binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 in rat brain following portacaval anastomosis. Brain Research. 585: 295-8. PMID 1324770 DOI: 10.1016/0006-8993(92)91222-Z  0.319
1991 Dauphin F, Richard JW, Seylaz J, Quirion R, Hamel E. Acetylcholine levels and choline acetyltransferase activity in rat cerebrovascular bed after uni- or bilateral sphenopalatine ganglionectomy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11: 253-60. PMID 1997497 DOI: 10.1038/Jcbfm.1991.57  0.351
1991 Dauphin F, Lacombe P, Sercombe R, Hamel E, Seylaz J. Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms. Brain Research. 553: 75-83. PMID 1933278 DOI: 10.1016/0006-8993(91)90232-K  0.312
1991 Dauphin F, Ting V, Payette P, Dennis M, Hamel E. Vasocontractile muscarinic M1 receptors in cat cerebral arteries: pharmacological identification and detection of mRNA. European Journal of Pharmacology. 207: 319-27. PMID 1783002 DOI: 10.1016/0922-4106(91)90006-4  0.331
1990 Hamel E, Assumel Lurdin C, Fage D, Edvinsson L, MacKenzie ET. Small pial vessels, but not choroid plexus, exhibit specific biochemical correlates of functional cholinergic innervation. Brain Research. 516: 301-9. PMID 2364295 DOI: 10.1016/0006-8993(90)90931-Z  0.359
1990 Dauphin F, Hamel E. Muscarinic receptor subtype mediating vasodilation feline middle cerebral artery exhibits M3 pharmacology. European Journal of Pharmacology. 178: 203-13. PMID 2328761 DOI: 10.1016/0014-2999(90)90476-M  0.338
1990 González C, Martin C, Hamel E, Galea E, Gómez B, Lluch S, Estrada C. Endothelial cells inhibit the vascular response to adrenergic nerve stimulation by a receptor-mediated mechanism Canadian Journal of Physiology and Pharmacology. 68: 104-109. PMID 2328438 DOI: 10.1139/Y90-016  0.339
1990 Chédotal A, Hamel E. Serotonin-synthesizing nerve fibers in rat and cat cerebral arteries and arterioles: immunohistochemistry of tryptophan-5-hydroxylase. Neuroscience Letters. 116: 269-74. PMID 2243604 DOI: 10.1016/0304-3940(90)90085-N  0.589
1990 Hamel E, Assumel-Lurdin C, Bouloy M, MacKenzie ET. Selective age-related changes in neuronal markers and smooth muscle reactivity in cerebrovascular beds of Fischer 344 rats. Neurobiology of Aging. 11: 631-9. PMID 1980721 DOI: 10.1016/0197-4580(90)90029-Y  0.327
1989 Hara H, Jansen I, Ekman R, Hamel E, MacKenzie ET, Uddman R, Edvinsson L. Acetylcholine and vasoactive intestinal peptide in cerebral blood vessels: effect of extirpation of the sphenopalatine ganglion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 9: 204-11. PMID 2921295 DOI: 10.1038/Jcbfm.1989.30  0.367
1989 Kiyosawa M, Baron JC, Hamel E, Pappata S, Duverger D, Riche D, Mazoyer B, Naquet R, MacKenzie ET. Time course of effects of unilateral lesions of the nucleus basalis of Meynert on glucose utilization by the cerebral cortex. Positron tomography in baboons. Brain : a Journal of Neurology. 112: 435-55. PMID 2784988 DOI: 10.1093/Brain/112.2.435  0.318
1988 Hamel E, Edvinsson L, MacKenzie ET. Heterogeneous vasomotor responses of anatomically distinct feline cerebral arteries. British Journal of Pharmacology. 94: 423-36. PMID 3395784 DOI: 10.1111/J.1476-5381.1988.Tb11544.X  0.31
1987 Hamel E, Assumel-Lurdin C, Edvinsson L, Fage D, MacKenzie ET. Neuronal versus endothelial origin of vasoactive acetylcholine in pial vessels. Brain Research. 420: 391-6. PMID 3676771 DOI: 10.1016/0006-8993(87)91263-7  0.344
1987 Hamel E, Beaudet A. Opioid receptors in rat neostriatum: radioautographic distribution at the electron microscopic level Brain Research. 401: 239-257. PMID 3028575 DOI: 10.1016/0006-8993(87)91409-0  0.309
1985 Edvinsson L, Fredholm BB, Hamel E, Jansen I, Verrecchia C. Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neuroscience Letters. 58: 213-7. PMID 2995876 DOI: 10.1016/0304-3940(85)90166-1  0.328
1984 Hamel E, Beaudet A. Electron microscopic autoradiographic localization of opioid receptors in rat neostriatum. Nature. 312: 155-157. PMID 6095083 DOI: 10.1038/312155A0  0.305
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