| Year |
Citation |
Score |
| 2023 |
Du L, Wilson BAP, Li N, Shah R, Dalilian M, Wang D, Smith EA, Wamiru A, Goncharova EI, Zhang P, O'Keefe BR. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. Journal of Natural Products. PMID 37843072 DOI: 10.1021/acs.jnatprod.3c00394 |
0.47 |
|
| 2023 |
Tian X, Wang D, Jiang W, Bokesch HR, Wilson BAP, O'Keefe BR, Gustafson KR. Rare Caulamidine Hexacyclic Alkaloids from the Marine Ascidian sp. Journal of Natural Products. PMID 37368408 DOI: 10.1021/acs.jnatprod.3c00393 |
0.4 |
|
| 2023 |
Wilson BAP, Li N, Martinez Fiesco JA, Dalilian M, Wang D, Smith EA, Wamiru A, Shah R, Goncharova EI, Beutler JA, Grkovic T, Zhang P, O'Keefe BR. Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors. Acs Pharmacology & Translational Science. 6: 633-650. PMID 37082750 DOI: 10.1021/acsptsci.3c00010 |
0.623 |
|
| 2022 |
Jiang W, Tian X, Wang D, Bokesch HR, Thomas CL, Woldemichael GM, Gryder BE, Wei JS, Song YK, Chou HC, Khan J, O'Keefe BR, Gustafson KR. Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid . Journal of Natural Products. PMID 35465663 DOI: 10.1021/acs.jnatprod.2c00246 |
0.454 |
|
| 2021 |
Jiang W, Wang D, Wilson BAP, Kang U, Bokesch HR, Smith EA, Wamiru A, Goncharova EI, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge . Marine Drugs. 19. PMID 34202500 DOI: 10.3390/md19070361 |
0.473 |
|
| 2021 |
Jiang W, Wang D, Wilson BAP, Voeller D, Bokesch HR, Smith EA, Lipkowitz S, O'Keefe BR, Gustafson KR. Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a sp. Soft Coral. Journal of Natural Products. PMID 34038132 DOI: 10.1021/acs.jnatprod.1c00367 |
0.436 |
|
| 2021 |
Wang D, Jiang W, Kim CK, Bokesch HR, Woldemichael GM, Gryder BE, Shern JF, Khan J, O'Keefe BR, Beutler JA, Gustafson KR. Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge sp. Organic Letters. PMID 33848174 DOI: 10.1021/acs.orglett.1c00743 |
0.555 |
|
| 2020 |
Kim CK, Wang D, Wilson BAP, Saurí J, Voeller D, Lipkowitz S, O'Keefe BR, Gustafson KR. Suberitamides A-C, Aryl Alkaloids from a sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity. Marine Drugs. 18. PMID 33126420 DOI: 10.3390/md18110536 |
0.416 |
|
| 2019 |
He M, Grkovic T, Evans JR, Thornburg CC, Akee RK, Thompson JR, Whitt JA, Harris MJ, Loyal JA, Britt JR, Jia L, White JD, Newman DJ, O'Keefe BR. The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species. Fitoterapia. 104285. PMID 31386897 DOI: 10.1016/J.Fitote.2019.104285 |
0.31 |
|
| 2019 |
Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruchirawat S, Kittakoop P, O'Keefe BR, Gustafson KR. NMR Characterization of Rearranged Staurosporine Aglycone Analogues from the Marine Sponge Damiria sp. Magnetic Resonance in Chemistry : Mrc. PMID 31379005 DOI: 10.1002/mrc.4932 |
0.325 |
|
| 2017 |
Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, et al. US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer. Journal of the National Cancer Institute. Monographs. 2017. PMID 29140488 DOI: 10.1093/Jncimonographs/Lgx007 |
0.466 |
|
| 2016 |
Shaffer C, Cai S, Perez A, Risinger A, Du L, O'Keefe B, Cichewicz R, Mooberry S. Abstract P5-04-18: Extracts derived from fungi and plants demonstrate specificity for subtyptes of triple negative breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P5-04-18 |
0.395 |
|
| 2015 |
Espindola L, Wilson B, Beutler J, Gustafson K, O'Keefe B. Brazilian cerrado biome plant extract bank screening in inflammatory disease and cancer enzymes Planta Medica. 81. DOI: 10.1055/S-0035-1556521 |
0.531 |
|
| 2015 |
Thornburg C, Grkovic T, Britt J, Akee R, Whitt J, Evans J, Grothaus P, Collins J, O'Keefe B. Development of a natural product-based fraction library for improved performance in high-throughput screening systems Planta Medica. 81. DOI: 10.1055/S-0035-1556299 |
0.306 |
|
| 2015 |
Grkovic T, Akee R, Evans J, Collins J, O'Keefe B. Biologically active natural products from Cassine viburnifolia Planta Medica. 81. DOI: 10.1055/S-0035-1556259 |
0.301 |
|
| 2014 |
Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, et al. Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins. Journal of Biomolecular Screening. 19: 1201-1211. PMID 24870016 DOI: 10.1177/1087057114536227 |
0.422 |
|
| 2014 |
Bermingham A, Price E, Marchand C, Whitson E, Gustafson K, McMahon J, Pommier Y, O'Keefe B. A screen for the identification of inhibitors of tyrosyl-DNA phosphodiesterase 1 Planta Medica. 80. DOI: 10.1055/S-0034-1382735 |
0.305 |
|
| 2014 |
Chan S, Henrich C, O'Keefe B, McKee T, McMahon J, Gustafson K. Isolation and identification of biologically active natural products from marine ascidians Planta Medica. 80. DOI: 10.1055/S-0034-1382375 |
0.339 |
|
| 2013 |
Castro A, Smith E, Haugh Krumpe L, O'Keefe B, Staudt L, McMahon J, Gustafson K. Natural Product Inhibitors of the Arginine-Specific Protease Activity of MALT1 Planta Medica. 79. DOI: 10.1055/S-0033-1348633 |
0.352 |
|
| 2013 |
Divlianska D, Wright A, Francis S, Walters M, Salomon C, Diaz P, Hassig C, O'Keefe B, Reed J, Roth G. In Search of Novel Cancer Therapeutics: Assessing the NCI Natural Product Library against Ten Anti-Apoptotic Protein Targets Planta Medica. 79. DOI: 10.1055/S-0033-1348587 |
0.331 |
|
| 2010 |
Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryotic Cell. 9: 1661-8. PMID 20852023 DOI: 10.1128/Ec.00166-10 |
0.317 |
|
| 2010 |
Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF. Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrobial Agents and Chemotherapy. 54: 3913-21. PMID 20547794 DOI: 10.1128/Aac.00434-10 |
0.562 |
|
| 2010 |
Alexandre KB, Gray ES, Lambson BE, Moore PL, Choge IA, Mlisana K, Karim SS, McMahon J, O'Keefe B, Chikwamba R, Morris L. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin. Virology. 402: 187-96. PMID 20392471 DOI: 10.1016/J.Virol.2010.03.021 |
0.376 |
|
| 2009 |
Bermingham A, Price E, Marchand C, Pommier Y, Goncharova K, Evans J, McMahon J, O'Keefe B. Abstract A174: High‐throughput screening for natural product inhibitors of human tyrosyl‐DNA‐phosphodiesterase (Tdp‐1) Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A174 |
0.429 |
|
| 2008 |
Weissman AM, Yang Y, Kitagaki J, Sasiela CA, Beutler JA, O'Keefe BR. Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer. Ernst Schering Foundation Symposium Proceedings. 171-90. PMID 19202599 |
0.543 |
|
| 2008 |
Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Acs Chemical Biology. 3: 635-44. PMID 18831589 DOI: 10.1021/Cb8001039 |
0.561 |
|
| 2008 |
Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen. Journal of Biomolecular Screening. 13: 229-37. PMID 18270365 DOI: 10.1177/1087057108315038 |
0.559 |
|
| 2007 |
Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB. An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis. Journal of Natural Products. 70: 1647-9. PMID 17935297 DOI: 10.1021/Np0702279 |
0.562 |
|
| 2004 |
Bokesch HR, Charan RD, Meragelman KM, Beutler JA, Gardella R, O'Keefe BR, McKee TC, McMahon JB. Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. Febs Letters. 567: 287-90. PMID 15178338 DOI: 10.1016/J.Febslet.2004.04.085 |
0.547 |
|
| 2002 |
Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, Boyd MR. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. Journal of Biomolecular Screening. 7: 105-10. PMID 12006108 DOI: 10.1177/108705710200700202 |
0.564 |
|
| 2000 |
Charan RD, Munro MH, O'Keefe BR, Sowder RCII, McKee TC, Currens MJ, Pannell LK, Boyd MR. Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii(1). Journal of Natural Products. 63: 1170-4. PMID 10978222 DOI: 10.1021/Np000039H |
0.333 |
|
| 2000 |
McMahon JB, Beutler JA, O'Keefe BR, Goodrum CB, Myers MA, Boyd MR. Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence. Journal of Biomolecular Screening. 5: 169-76. PMID 10894760 DOI: 10.1177/108705710000500309 |
0.571 |
|
| 1998 |
O'Keefe BR, Erim T, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Johnson DG, Buckheit RW, Halliday S, Boyd MR. Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. Febs Letters. 431: 85-90. PMID 9684871 DOI: 10.1016/S0014-5793(98)00736-4 |
0.554 |
|
| 1997 |
O'Keefe BR, Beutler JA, Cardellina JH, Prather TR, Shoemaker RH, Sowder RC, Henderson LE, Pannell LK, Boyd MR. Isolation of a novel Kunitz family protease inhibitor in association with Tethya hemolysin from the sponge Tethya ingalli. Journal of Natural Products. 60: 1094-9. PMID 9392878 DOI: 10.1021/Np970242L |
0.547 |
|
| 1997 |
O'Keefe BR, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Henderson LE, Pannell LK, Pomponi SA, Boyd MR. Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta. European Journal of Biochemistry / Febs. 245: 47-53. PMID 9128723 DOI: 10.1111/J.1432-1033.1997.T01-1-00047.X |
0.547 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2015 |
Risinger A, Du L, Robles A, Sarkar P, Perez A, King J, Dybdal-Hargreaves N, Dai W, O'Keefe B, Cichewicz R, Mooberry S. Utilizing differential cytotoxicity screening to identify lead compounds for rare adult and pediatric tumors Planta Medica. 81. DOI: 10.1055/S-0035-1556136 |
0.298 |
|
| 2005 |
Mori T, O'Keefe BR, Sowder RC, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW, McMahon JB, Boyd MR. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. The Journal of Biological Chemistry. 280: 9345-53. PMID 15613479 DOI: 10.1074/jbc.M411122200 |
0.293 |
|
| 2017 |
Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR. Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1). Slas Discovery. 2472555217717200. PMID 28697309 DOI: 10.1177/2472555217717200 |
0.293 |
|
| 2016 |
Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K. Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. PMID 27797192 DOI: 10.1021/acs.jnatprod.6b00645 |
0.289 |
|
| 2020 |
Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR. NCI Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library. Acs Chemical Biology. PMID 32223208 DOI: 10.1021/Acschembio.0C00139 |
0.286 |
|
| 2020 |
Grant CV, Cai S, Risinger AL, Liang H, O'Keefe BR, Doench JG, Cichewicz RH, Mooberry SL. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. Journal of Natural Products. PMID 33021790 DOI: 10.1021/acs.jnatprod.0c00642 |
0.286 |
|
| 2023 |
Martínez-Fructuoso L, Arends SJR, Freire VF, Evans JR, DeVries S, Peyser BD, Akee RK, Thornburg CC, Kumar R, Ensel S, Morgan GM, McConachie GD, Veeder N, Duncan LR, Grkovic T, et al. Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library. Acs Infectious Diseases. PMID 37163243 DOI: 10.1021/acsinfecdis.3c00067 |
0.283 |
|
| 2018 |
Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Journal of Natural Products. PMID 30106296 DOI: 10.1021/Acs.Jnatprod.8B00411 |
0.277 |
|
| 2016 |
Robles AJ, Cai S, Du L, Shaffer CV, Grkovic T, Risinger AL, O'Keefe BR, Cichewicz RH, Mooberry SL. Identifying specific inhibitors of triple-negative breast cancer subtypes. Planta Medica. 81: S1-S381. PMID 27975763 DOI: 10.1055/S-0036-1596562 |
0.275 |
|
| 2020 |
Krumpe LRH, Wilson BAP, Marchand C, Sunassee SN, Bermingham A, Wang W, Price E, Guszczynski T, Kelley JA, Gustafson KR, Pommier Y, Rosengren KJ, Schroeder CI, O'Keefe BR. Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I. Journal of the American Chemical Society. PMID 33263997 DOI: 10.1021/jacs.0c10418 |
0.275 |
|
| 2020 |
Tran TD, Wilson BAP, Henrich CJ, Wendt KL, King J, Cichewicz RH, Stchigel AM, Miller AN, O'Keefe BR, Gustafson KR. Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry. 173: 112278. PMID 32078832 DOI: 10.1016/J.Phytochem.2020.112278 |
0.273 |
|
| 2002 |
Botos I, O'Keefe BR, Shenoy SR, Cartner LK, Ratner DM, Seeberger PH, Boyd MR, Wlodawer A. Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides. The Journal of Biological Chemistry. 277: 34336-42. PMID 12110688 DOI: 10.1074/Jbc.M205909200 |
0.273 |
|
| 2003 |
Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC, Turpin J, Watson K, Buckheit RW, Boyd MR. A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry. 42: 2578-84. PMID 12614152 DOI: 10.1021/bi0205698 |
0.272 |
|
| 2020 |
Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of . Journal of Natural Products. PMID 32105068 DOI: 10.1021/Acs.Jnatprod.9B00896 |
0.27 |
|
| 2015 |
Moulaei T, Alexandre KB, Shenoy SR, Meyerson JR, Krumpe LR, Constantine B, Wilson J, Buckheit RW, McMahon JB, Subramaniam S, Wlodawer A, O'Keefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology. 12: 6. PMID 25613831 DOI: 10.1186/S12977-014-0127-3 |
0.269 |
|
| 2016 |
He M, Grkovic T, Thornburg CC, Whitt J, Akee R, Thompson J, Britt J, Jia L, White J, Newman D, O'Keefe B. A prototype traditional Chinese medicinal plant library at the National Cancer Institute. Planta Medica. 81: S1-S381. PMID 27975690 DOI: 10.1055/S-0036-1596489 |
0.269 |
|
| 2014 |
Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SF, O'Keefe BR, Schneekloth JS. Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays. Journal of the American Chemical Society. 136: 8402-10. PMID 24820959 DOI: 10.1021/Ja502754F |
0.268 |
|
| 2006 |
Xiong C, O'Keefe BR, Botos I, Wlodawer A, McMahon JB. Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expression and Purification. 46: 233-9. PMID 16289703 DOI: 10.1016/j.pep.2005.09.019 |
0.267 |
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| 2013 |
Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR. Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. Plos One. 8: e64449. PMID 23700478 DOI: 10.1055/S-0032-1320301 |
0.266 |
|
| 2016 |
Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stöger E, Christou P, Capell T. Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnology Journal. PMID 26800650 DOI: 10.1111/Pbi.12507 |
0.266 |
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| 2018 |
Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T. Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm. Proceedings of the National Academy of Sciences of the United States of America. PMID 30061386 DOI: 10.1073/pnas.1806022115 |
0.266 |
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| 2016 |
Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T. Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro. Plant Cell Reports. 35: 1309-19. PMID 27007716 DOI: 10.1007/s00299-016-1963-5 |
0.265 |
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| 1997 |
Boyd MR, Gustafson KR, McMahon JB, Shoemaker RH, O'Keefe BR, Mori T, Gulakowski RJ, Wu L, Rivera MI, Laurencot CM, Currens MJ, Cardellina JH, Buckheit RW, Nara PL, Pannell LK, et al. Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development. Antimicrobial Agents and Chemotherapy. 41: 1521-30. PMID 9210678 DOI: 10.1128/AAC.41.7.1521 |
0.265 |
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| 2019 |
Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines. Journal of Natural Products. PMID 30830773 DOI: 10.1021/Acs.Jnatprod.8B01015 |
0.263 |
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| 2019 |
Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities. Journal of Natural Products. PMID 30600998 DOI: 10.1021/Acs.Jnatprod.8B00871 |
0.262 |
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| 2006 |
Xiong C, O'Keefe BR, Byrd RA, McMahon JB. Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides. 27: 1668-75. PMID 16647158 DOI: 10.1016/J.Peptides.2006.03.018 |
0.262 |
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| 2009 |
O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component Proceedings of the National Academy of Sciences of the United States of America. 106: 6099-6104. PMID 19332801 DOI: 10.1073/pnas.0901506106 |
0.26 |
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| 2017 |
Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa. The Journal of Organic Chemistry. PMID 29286245 DOI: 10.1021/acs.joc.7b02951 |
0.258 |
|
| 2010 |
Moulaei T, Shenoy SR, Giomarelli B, Thomas C, McMahon JB, Dauter Z, O'Keefe BR, Wlodawer A. Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure (London, England : 1993). 18: 1104-15. PMID 20826337 DOI: 10.1016/j.str.2010.05.016 |
0.257 |
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| 1998 |
Mariner JM, McMahon JB, O'Keefe BR, Nagashima K, Boyd MR. The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding. Biochemical and Biophysical Research Communications. 248: 841-5. PMID 9704015 DOI: 10.1006/BBRC.1998.9060 |
0.255 |
|
| 2005 |
Maderia M, Wu J, Bax A, Shenoy S, O'Keefe B, Marquez VE, Barchi JJ. Engineering DNA topology with locked nucleosides: a structural study. Nucleosides, Nucleotides & Nucleic Acids. 24: 687-90. PMID 16248015 DOI: 10.1081/Ncn-200060256 |
0.255 |
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| 2018 |
Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Grkovic T, O'Keefe BR. NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening. Acs Chemical Biology. PMID 29812901 DOI: 10.1021/Acschembio.8B00389 |
0.254 |
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| 2015 |
O'Keefe BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araújo AC, Lacorte CC, Madeira L, McMahon JB, Rech EL. Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV. Plant Biotechnology Journal. PMID 25572960 DOI: 10.1111/pbi.12309 |
0.253 |
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| 2014 |
Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG, McMahon JB, Huggins J, O'Keefe BR. The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus. Antiviral Research. 112: 1-7. PMID 25265598 DOI: 10.1016/J.Antiviral.2014.09.012 |
0.142 |
|
| 2007 |
Ziółkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A. Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine. Protein Science : a Publication of the Protein Society. 16: 1485-9. PMID 17567736 DOI: 10.1110/ps.072889407 |
0.14 |
|
| 2004 |
Ratner DM, Adams EW, Su J, O'Keefe BR, Mrksich M, Seeberger PH. Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides Chembiochem. 5: 379-382. PMID 14997532 DOI: 10.1002/Cbic.200300804 |
0.128 |
|
| 2012 |
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors. Journal of Medicinal Chemistry. 55: 7297. PMID 22891611 DOI: 10.1021/Jm301167V |
0.125 |
|
| 2020 |
Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O'Keefe BR, Spiropoulou CF. Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge. The Journal of Infectious Diseases. PMID 32037447 DOI: 10.1093/Infdis/Jiz630 |
0.124 |
|
| 2007 |
Moulaei T, Botos I, Ziółkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A. Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Science : a Publication of the Protein Society. 16: 2756-60. PMID 17965185 DOI: 10.1110/ps.073157507 |
0.123 |
|
| 2015 |
Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, Fernández-Romero JA. Griffithsin and carrageenan combination to target HSV-2 and HPV. Antimicrobial Agents and Chemotherapy. PMID 26369967 DOI: 10.1128/Aac.01816-15 |
0.122 |
|
| 1997 |
O'Keefe BR, Mahady GB, Gills JJ, Beecher CWW, Schilling AB. Stable vindoline production in transformed cell cultures of Catharanthus roseus Journal of Natural Products. 60: 261-264. DOI: 10.1021/Np960703N |
0.112 |
|
| 2021 |
Grkovic T, Ruchirawat S, Kittakoop P, Grothaus PG, Evans JR, Britt JR, Newman DJ, Mahidol C, O'Keefe BR. A New Bispyrroloiminoquinone Alkaloid From a Thai Collection of
Clavelina
sp. Asian Journal of Organic Chemistry. 10: 1647-1649. DOI: 10.1002/AJOC.202100155 |
0.111 |
|
| 2007 |
Smee DF, Wandersee MK, Checketts MB, O'Keefe BR, Saucedo C, Boyd MR, Mishin VP, Gubareva LV. Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor. Antiviral Chemistry & Chemotherapy. 18: 317-27. PMID 18320936 |
0.11 |
|
| 2021 |
Woldemichael GM, O'Keefe BR. Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs. Structure (London, England : 1993). 29: 401-403. PMID 33961789 DOI: 10.1016/j.str.2021.03.010 |
0.107 |
|
| 2016 |
Wlodawer A, Lubkowski J, Gustchina A, Zhou D, Jakob M, O'Keefe BR, da Silva Ferreira R, Lobo YA, Hansen D, Oliva MLV. Structural studies of medically-interesting protease inhibitors and lectins that belong to the β-trefoil family Acta Crystallographica Section a Foundations and Advances. 72: s33-s33. DOI: 10.1107/S2053273316099484 |
0.105 |
|
| 2008 |
Smee DF, Bailey KW, Wong MH, O'Keefe BR, Gustafson KR, Mishin VP, Gubareva LV. Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N. Antiviral Research. 80: 266-71. PMID 18601954 DOI: 10.1016/j.antiviral.2008.06.003 |
0.104 |
|
| 2018 |
White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL. India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base. Journal of Global Oncology. 1-10. PMID 30241135 DOI: 10.1200/Jgo.17.00099 |
0.096 |
|
| 2005 |
O'Keefe BR. Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs Edited by R. J. Y. Ho and M. Gibaldi (University of Washington). Wiley-LISS, New York. 2003. xvii + 556 pp. 7 × 10 in. $83.95. ISBN 0-471-20690-3. Journal of Natural Products. 68: 630-630. DOI: 10.1021/np058230k |
0.081 |
|
| 2016 |
Chau CH, O'Keefe BR, Figg WD. The canSAR data hub for drug discovery. The Lancet. Oncology. 17: 286. PMID 26972856 DOI: 10.1016/S1470-2045(16)00095-4 |
0.058 |
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