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Stephen P. Bell - Publications

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Biochemistry, Molecular Biology
Website:
https://biology.mit.edu/people/stephen_bell

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Phizicky DV, Bell SP. Transcriptional repression of CDC6 and SLD2 during meiosis is associated with production of short heterogeneous RNA isoforms. Chromosoma. PMID 30276463 DOI: 10.1007/s00412-018-0681-x  0.4
2018 Phizicky DV, Berchowitz LE, Bell SP. Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis. Elife. 7. PMID 29388912 DOI: 10.7554/Elife.33309  0.4
2015 Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC. The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level. Molecular Cell. 58: 483-94. PMID 25921072 DOI: 10.1016/J.Molcel.2015.03.017  1
2015 Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC. The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level. Molecular Cell. 58: 483-94. PMID 25921072 DOI: 10.1016/J.Molcel.2015.03.017  1
2015 Ticau S, Friedman LJ, Ivica NA, Gelles J, Bell SP. Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading. Cell. 161: 513-25. PMID 25892223 DOI: 10.1016/J.Cell.2015.03.012  1
2015 Ticau S, Friedman LJ, Ivica NA, Gelles J, Bell SP. Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading. Cell. 161: 513-25. PMID 25892223 DOI: 10.1016/J.Cell.2015.03.012  1
2014 Bell SP. Terminating the replisome: Multiple proteins modify and dismantle a key enzyme after DNA replication terminates Science. 346: 418-419. PMID 25342784 DOI: 10.1126/Science.1261245  1
2014 Froelich CA, Kang S, Epling LB, Bell SP, Enemark EJ. A conserved MCM single-stranded DNA binding element is essential for replication initiation Elife. 2014. DOI: 10.7554/eLife.01993  1
2012 Blitzblau HG, Chan CS, Hochwagen A, Bell SP. Separation of DNA replication from the assembly of break-competent meiotic chromosomes. Plos Genetics. 8: e1002643. PMID 22615576 DOI: 10.1371/journal.pgen.1002643  1
2011 Takara TJ, Bell SP. Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases Embo Journal. 30: 4885-4896. PMID 22045335 DOI: 10.1038/Emboj.2011.394  1
2011 Heller RC, Kang S, Lam WM, Chen S, Chan CS, Bell SP. Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell. 146: 80-91. PMID 21729781 DOI: 10.1016/j.cell.2011.06.012  1
2011 Heller RC, Kang S, Lam WM, Chen S, Chan CS, Bell SP. Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell. 146: 80-91. PMID 21729781 DOI: 10.1016/j.cell.2011.06.012  1
2011 Chen S, Bell SP. CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6 Genes and Development. 25: 363-372. PMID 21289063 DOI: 10.1101/gad.2011511  1
2010 Randell JCW, Fan A, Chan C, Francis LI, Heller RC, Galani K, Bell SP. Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7 Molecular Cell. 40: 353-363. PMID 21070963 DOI: 10.1016/j.molcel.2010.10.017  1
2010 Eaton ML, Galani K, Kang S, Bell SP, MacAlpine DM. Conserved nucleosome positioning defines replication origins Genes and Development. 24: 748-753. PMID 20351051 DOI: 10.1101/Gad.1913210  1
2010 Tsakraklides V, Bell SP. Dynamics of pre-replicative complex assembly Journal of Biological Chemistry. 285: 9437-9443. PMID 20097898 DOI: 10.1074/Jbc.M109.072504  1
2009 Takara TJ, Bell SP. Putting two heads together to unwind DNA. Cell. 139: 652-4. PMID 19914158 DOI: 10.1016/J.Cell.2009.10.037  1
2009 Francis LI, Randell JCW, Takara TJ, Uchima L, Bell SP. Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation Genes and Development. 23: 643-654. PMID 19270162 DOI: 10.1101/Gad.1759609  1
2008 Bochman ML, Bell SP, Schwacha A. Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability Molecular and Cellular Biology. 28: 5865-5873. PMID 18662997 DOI: 10.1128/Mcb.00161-08  1
2007 Blitzblau HG, Bell GW, Rodriguez J, Bell SP, Hochwagen A. Mapping of Meiotic Single-Stranded DNA Reveals Double-Strand-Break Hotspots near Centromeres and Telomeres Current Biology. 17: 2003-2012. PMID 18060788 DOI: 10.1016/J.Cub.2007.10.066  1
2007 Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. The Embo Journal. 26: 4974-84. PMID 18007591 DOI: 10.1038/Sj.Emboj.7601926  1
2007 Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. The Embo Journal. 26: 4974-84. PMID 18007591 DOI: 10.1038/Sj.Emboj.7601926  1
2007 Chen S, de Vries MA, Bell SP. Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Genes & Development. 21: 2897-907. PMID 18006685 DOI: 10.1101/Gad.1596807  1
2007 Chen S, de Vries MA, Bell SP. Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Genes & Development. 21: 2897-907. PMID 18006685 DOI: 10.1101/Gad.1596807  1
2007 Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Bell SP, Speed T, Manak JR, Botchan MR. Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes & Development. 21: 2880-96. PMID 17978103 DOI: 10.1101/Gad.1600107  1
2006 Gibson DG, Bell SP, Aparicio OM. Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae Genes to Cells. 11: 557-573. PMID 16716188 DOI: 10.1111/J.1365-2443.2006.00967.X  1
2006 Tanny RE, MacAlpine DM, Blitzblau HG, Bell SP. Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation Molecular Biology of the Cell. 17: 2415-2423. PMID 16525018 DOI: 10.1091/Mbc.E05-11-1037  1
2006 Randell JCW, Bowers JL, Rodríguez HK, Bell SP. Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase Molecular Cell. 21: 29-39. PMID 16387651 DOI: 10.1016/J.Molcel.2005.11.023  1
2006 Sivaprasad U, Dutta A, Bell SP. 3 Assembly of Pre-replication Complexes Cold Spring Harbor Monograph Archive. 47: 63-88. DOI: 10.1101/087969766.47.63  1
2005 MacAlpine DM, Bell SP. A genomic view of eukaryotic DNA replication. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 13: 309-326. PMID 15868424 DOI: 10.1007/S10577-005-1508-1  1
2004 Bowers JL, Randell JCW, Chen S, Bell SP. ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication Molecular Cell. 16: 967-978. PMID 15610739 DOI: 10.1016/J.Molcel.2004.11.038  1
2004 MacAlpine DM, Rodríguez HK, Bell SP. Coordination of replication and transcription along a Drosophila chromosome Genes and Development. 18: 3094-3105. PMID 15601823 DOI: 10.1101/Gad.1246404  1
2004 Chastain PD, Bowers JL, Lee DG, Bell SP, Griffith JD. Mapping subunit location on the Saccharomyces cerevisiae origin recognition complex free and bound to DNA using a novel nanoscale biopointer Journal of Biological Chemistry. 279: 36354-36362. PMID 15201282 DOI: 10.1074/Jbc.M403501200  1
2004 Schübeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, Groudine M. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes & Development. 18: 1263-71. PMID 15175259 DOI: 10.1101/Gad.1198204  1
2004 Schübeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, Groudine M. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes & Development. 18: 1263-71. PMID 15175259 DOI: 10.1101/Gad.1198204  1
2004 Wilmes GM, Archambault V, Austin RJ, Jacobson MD, Bell SP, Cross FR. Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes & Development. 18: 981-91. PMID 15105375 DOI: 10.1101/Gad.1202304  1
2004 Wilmes GM, Archambault V, Austin RJ, Jacobson MD, Bell SP, Cross FR. Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes & Development. 18: 981-91. PMID 15105375 DOI: 10.1101/Gad.1202304  1
2002 Lau A, Blitzblau H, Bell SP. Cell-cycle control of the establishment of mating-type silencing in S. cerevisiae Genes and Development. 16: 2935-2945. PMID 12435634 DOI: 10.1101/Gad.764102  1
2002 Claycomb JM, MacAlpine DM, Evans JG, Bell SP, Orr-Weaver TL. Visualization of replication initiation and elongation in Drosophila. The Journal of Cell Biology. 159: 225-36. PMID 12403810 DOI: 10.1083/Jcb.200207046  1
2002 Claycomb JM, MacAlpine DM, Evans JG, Bell SP, Orr-Weaver TL. Visualization of replication initiation and elongation in Drosophila. The Journal of Cell Biology. 159: 225-36. PMID 12403810 DOI: 10.1083/Jcb.200207046  1
2002 Bell SP, Dutta A. DNA replication in eukaryotic cells Annual Review of Biochemistry. 71: 333-374. PMID 12045100 DOI: 10.1146/Annurev.Biochem.71.110601.135425  1
2002 Bell SP. The origin recognition complex: From simple origins to complex functions Genes and Development. 16: 659-672. PMID 11914271 DOI: 10.1101/Gad.969602  1
2002 Wilmes GM, Bell SP. The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation. Proceedings of the National Academy of Sciences of the United States of America. 99: 101-6. PMID 11756674 DOI: 10.1073/Pnas.012578499  1
2002 Wilmes GM, Bell SP. The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation. Proceedings of the National Academy of Sciences of the United States of America. 99: 101-6. PMID 11756674 DOI: 10.1073/Pnas.012578499  1
2001 Wyrick JJ, Aparicio JG, Chen T, Barnett JD, Jennings EG, Young RA, Bell SP, Aparicio OM. Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science (New York, N.Y.). 294: 2357-60. PMID 11743203 DOI: 10.1126/Science.1066101  1
2001 Wyrick JJ, Aparicio JG, Chen T, Barnett JD, Jennings EG, Young RA, Bell SP, Aparicio OM. Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science (New York, N.Y.). 294: 2357-60. PMID 11743203 DOI: 10.1126/Science.1066101  1
2001 Schwacha A, Bell SP. Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication Molecular Cell. 8: 1093-1104. PMID 11741544 DOI: 10.1016/S1097-2765(01)00389-6  1
2001 Klemm RD, Bell SP. ATP bound to the origin recognition complex is important for preRC formation. Proceedings of the National Academy of Sciences of the United States of America. 98: 8361-7. PMID 11459976 DOI: 10.1073/Pnas.131006898  1
2001 Klemm RD, Bell SP. ATP bound to the origin recognition complex is important for preRC formation. Proceedings of the National Academy of Sciences of the United States of America. 98: 8361-7. PMID 11459976 DOI: 10.1073/Pnas.131006898  1
2001 Lipford JR, Bell SP. Nucleosomes positioned by ORC facilitate the initiation of DNA replication Molecular Cell. 7: 21-30. PMID 11172708 DOI: 10.1016/S1097-2765(01)00151-4  1
2000 Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J, Schreiber J, Hannett N, Kanin E, Volkert TL, Wilson CJ, Bell SP, Young RA. Genome-wide location and function of DNA binding proteins. Science (New York, N.Y.). 290: 2306-9. PMID 11125145 DOI: 10.1126/science.290.5500.2306  1
2000 Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J, Schreiber J, Hannett N, Kanin E, Volkert TL, Wilson CJ, Bell SP, Young RA. Genome-wide location and function of DNA binding proteins. Science (New York, N.Y.). 290: 2306-9. PMID 11125145 DOI: 10.1126/science.290.5500.2306  1
2000 Lee DG, Makhov AM, Klemm RD, Griffith JD, Bell SP. Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding. The Embo Journal. 19: 4774-82. PMID 10970868 DOI: 10.1093/Emboj/19.17.4774  1
2000 Lee DG, Makhov AM, Klemm RD, Griffith JD, Bell SP. Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding. The Embo Journal. 19: 4774-82. PMID 10970868 DOI: 10.1093/Emboj/19.17.4774  1
1999 Austin RJ, Orr-Weaver TL, Bell SP. Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element. Genes & Development. 13: 2639-49. PMID 10541550 DOI: 10.1101/Gad.13.20.2639  1
1999 Aparicio OM, Stout AM, Bell SP. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 96: 9130-5. PMID 10430907 DOI: 10.1073/Pnas.96.16.9130  1
1999 Royzman I, Austin RJ, Bosco G, Bell SP, Orr-Weaver TL. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes & Development. 13: 827-40. PMID 10197983 DOI: 10.1101/Gad.13.7.827  1
1998 Baker TA, Bell SP. Polymerases and the replisome: machines within machines. Cell. 92: 295-305. PMID 9476890 DOI: 10.1016/S0092-8674(00)80923-X  1
1997 Dutta A, Bell SP. Initiation of DNA replication in eukaryotic cells. Annual Review of Cell and Developmental Biology. 13: 293-332. PMID 9442876 DOI: 10.1146/Annurev.Cellbio.13.1.293  1
1997 Lee DG, Bell SP. Architecture of the yeast origin recognition complex bound to origins of DNA replication. Molecular and Cellular Biology. 17: 7159-68. PMID 9372948 DOI: 10.1128/Mcb.17.12.7159  1
1997 Aparicio OM, Weinstein DM, Bell SP. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell. 91: 59-69. PMID 9335335 DOI: 10.1016/S0092-8674(01)80009-X  1
1997 Klemm RD, Austin RJ, Bell SP. Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell. 88: 493-502. PMID 9038340 DOI: 10.1016/S0092-8674(00)81889-9  1
1995 Bell SP. Eukaryotic replicators and associated protein complexes. Current Opinion in Genetics & Development. 5: 162-7. PMID 7613084 DOI: 10.1016/0959-437X(95)80003-4  1
1995 Bell SP, Mitchell J, Leber J, Kobayashi R, Stillman B. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell. 83: 563-8. PMID 7585959 DOI: 10.1016/0092-8674(95)90096-9  1
1993 Bell SP, Kobayashi R, Stillman B. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science (New York, N.Y.). 262: 1844-9. PMID 8266072 DOI: 10.1126/Science.8266072  1
1993 Bell SP, Marahrens Y, Rao H, Stillman B. The replicon model and eukaryotic chromosomes. Cold Spring Harbor Symposia On Quantitative Biology. 58: 435-42. PMID 7956057 DOI: 10.1101/Sqb.1993.058.01.050  1
1992 Bell SP, Stillman B. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature. 357: 128-34. PMID 1579162 DOI: 10.1038/357128A0  1
1992 Stillman B, Bell SP, Dutta A, Marahrens Y. DNA replication and the cell cycle. Ciba Foundation Symposium. 170: 147-56; discussion 1. PMID 1336449  1
1990 Bell SP, Jantzen HM, Tjian R. Assembly of alternative multiprotein complexes directs rRNA promoter selectivity. Genes & Development. 4: 943-54. PMID 2384215 DOI: 10.1101/Gad.4.6.943  1
1990 Jantzen HM, Admon A, Bell SP, Tjian R. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature. 344: 830-6. PMID 2330041 DOI: 10.1038/344830A0  1
1989 Bell SP, Pikaard CS, Reeder RH, Tjian R. Molecular mechanisms governing species-specific transcription of ribosomal RNA. Cell. 59: 489-97. PMID 2805069 DOI: 10.1016/0092-8674(89)90032-9  1
1989 Pikaard CS, McStay B, Schultz MC, Bell SP, Reeder RH. The Xenopus ribosomal gene enhancers bind an essential polymerase I transcription factor, xUBF. Genes & Development. 3: 1779-88. PMID 2606347 DOI: 10.1101/Gad.3.11.1779  1
1988 Bell SP, Learned RM, Jantzen HM, Tjian R. Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Science (New York, N.Y.). 241: 1192-7. PMID 3413483 DOI: 10.1126/Science.3413483  1
1986 Briggs MR, Kadonaga JT, Bell SP, Tjian R. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science (New York, N.Y.). 234: 47-52. PMID 3529394 DOI: 10.1126/Science.3529394  1
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