Matthew G. Vander Heiden - Publications

Affiliations: 
Biology  Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
cancer metabolism
Website:
https://biology.mit.edu/people/matthew_vander_heiden

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lien EC, Vander Heiden MG. A framework for examining how diet impacts tumour metabolism. Nature Reviews. Cancer. PMID 31530936 DOI: 10.1038/s41568-019-0198-5  0.36
2016 Mattaini KR, Sullivan MR, Vander Heiden MG. The importance of serine metabolism in cancer. The Journal of Cell Biology. PMID 27458133 DOI: 10.1083/jcb.201604085  0.92
2016 Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Developmental Cell. 36: 540-9. PMID 26954548 DOI: 10.1016/j.devcel.2016.02.012  0.92
2016 Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. The Journal of Cell Biology. 212: 439-47. PMID 26880201 DOI: 10.1083/jcb.201506118  0.92
2016 Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, ... ... Vander Heiden MG, et al. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metabolism. PMID 26853747 DOI: 10.1016/j.cmet.2016.01.007  0.92
2016 Yuan C, Clish CB, Wu C, Mayers JR, Kraft P, Townsend MK, Zhang M, Tworoger SS, Bao Y, Qian ZR, Rubinson DA, Ng K, Giovannucci EL, Ogino S, Stampfer MJ, ... ... Vander Heiden MG, et al. Circulating Metabolites and Survival Among Patients With Pancreatic Cancer. Journal of the National Cancer Institute. 108. PMID 26755275 DOI: 10.1093/jnci/djv409  0.92
2015 Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Cooperative nutrient accumulation sustains growth of mammalian cells. Scientific Reports. 5: 17401. PMID 26620632 DOI: 10.1038/srep17401  0.92
2015 Lau AN, Vander Heiden MG. Stopping the Clock with MYC. Molecular Cell. 60: 511-3. PMID 26590710 DOI: 10.1016/j.molcel.2015.11.008  0.92
2015 Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Vander Heiden MG, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/j.semcancer.2015.09.007  0.8
2015 Liu VM, Vander Heiden MG. The Role of Pyruvate Kinase M2 in Cancer Metabolism. Brain Pathology (Zurich, Switzerland). 25: 781-3. PMID 26526946 DOI: 10.1111/bpa.12311  0.92
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, ... ... Vander Heiden MG, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  0.92
2015 Hosios AM, Fiske BP, Gui DY, Vander Heiden MG. Lack of Evidence for PKM2 Protein Kinase Activity. Molecular Cell. 59: 850-7. PMID 26300261 DOI: 10.1016/j.molcel.2015.07.013  0.92
2015 Israelsen WJ, Vander Heiden MG. Pyruvate kinase: Function, regulation and role in cancer. Seminars in Cell & Developmental Biology. PMID 26277545 DOI: 10.1016/j.semcdb.2015.08.004  0.92
2015 Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Cell. 162: 552-63. PMID 26232225 DOI: 10.1016/j.cell.2015.07.017  0.92
2015 Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG. An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation. Cancer & Metabolism. 3: 5. PMID 25926973 DOI: 10.1186/s40170-015-0131-7  0.4
2015 Yang NJ, Liu DV, Sklaviadis D, Gui DY, Vander Heiden MG, Wittrup KD. Antibody-mediated neutralization of perfringolysin o for intracellular protein delivery. Molecular Pharmaceutics. 12: 1992-2000. PMID 25881713 DOI: 10.1021/mp500797n  0.92
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, ... ... Vander Heiden MG, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/nature14363  0.92
2015 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Vander Heiden MG, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/j.copbio.2015.02.003  0.92
2015 Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research. 75: 544-53. PMID 25644265 DOI: 10.1158/0008-5472.CAN-14-2211  0.52
2015 Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. Acs Chemical Biology. 10: 510-6. PMID 25406093 DOI: 10.1021/cb500683c  0.92
2015 Anastasiou D, Locasale JW, Vander Heiden MG. Cancer metabolism Systems Biology of Cancer. 295-308. DOI: 10.1017/9780511979811.020  0.92
2015 Mayers JR, Vander Heiden MG. Famine versus feast: Understanding the metabolism of tumors in vivo Trends in Biochemical Sciences. 40: 130-140. DOI: 10.1016/j.tibs.2015.01.004  0.92
2015 Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PNM, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, ... ... Vander Heiden MG, et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation Molecular Cell. 57: 95-107. DOI: 10.1016/j.molcel.2014.10.027  0.92
2014 Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, ... ... Vander Heiden MG, et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nature Medicine. 20: 1193-8. PMID 25261994 DOI: 10.1038/nm.3686  0.92
2014 Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 158: 1309-23. PMID 25215489 DOI: 10.1016/j.cell.2014.07.048  0.8
2014 Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Molecular Cell. 55: 253-63. PMID 24882210 DOI: 10.1016/j.molcel.2014.05.008  0.92
2014 Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, ... ... Vander Heiden MG, et al. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nature Communications. 5: 3608. PMID 24699711 DOI: 10.1038/ncomms4608  0.92
2014 Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J. A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. The Journal of Biological Chemistry. 289: 13010-25. PMID 24634222 DOI: 10.1074/jbc.M113.546515  0.92
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, ... ... Vander Heiden MG, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/j.cell.2013.09.025  0.92
2013 Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/j.stem.2013.09.001  0.92
2013 Mayers JR, Vander Heiden MG. BCAT1 defines gliomas by IDH status Nature Medicine. 19: 816-817. PMID 23836221 DOI: 10.1038/nm.3263  0.92
2013 Olenchock BA, Vander Heiden MG. XPyruvate as a pivot point for oncogene-induced senescence Cell. 153: X1429-1430. PMID 23791173 DOI: 10.1016/j.cell.2013.06.001  0.92
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, ... ... Vander Heiden MG, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.CAN-13-0080  0.92
2013 Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 497: 633-7. PMID 23665962 DOI: 10.1038/nature12138  0.92
2013 Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nature Biotechnology. 31: 522-9. PMID 23604282 DOI: 10.1038/nbt.2530  0.92
2013 Gui DY, Lewis CA, Vander Heiden MG. Allosteric regulation of PKM2 allows cellular adaptation to different physiological states. Science Signaling. 6: pe7. PMID 23423437 DOI: 10.1126/scisignal.2003925  0.92
2013 Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, ... ... Vander Heiden MG, et al. Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2929-40. PMID 23403635 DOI: 10.1158/1078-0432.CCR-12-2307  0.92
2013 Metallo CM, Vander Heiden MG. Understanding Metabolic Regulation and Its Influence on Cell Physiology Molecular Cell. 49: 388-398. PMID 23395269 DOI: 10.1016/j.molcel.2013.01.018  0.92
2013 Harris JM, Esain V, Frechette GM, Harris LJ, Cox AG, Cortes M, Garnaas MK, Carroll KJ, Cutting CC, Khan T, Elks PM, Renshaw SA, Dickinson BC, Chang CJ, Murphy MP, ... ... Vander Heiden MG, et al. Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood. 121: 2483-93. PMID 23341543 DOI: 10.1182/blood-2012-12-471201  0.92
2012 Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, ... ... Vander Heiden MG, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry & Biology. 19: 1187-98. PMID 22999886 DOI: 10.1016/j.chembiol.2012.07.021  0.8
2012 Mattaini KR, Vander Heiden MG. Glycosylation to adapt to stress Science. 337: 925-926. PMID 22923571 DOI: 10.1126/science.1227513  0.92
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Vander Heiden MG, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/nchembio.1060  0.8
2012 Fiske BP, Vander Heiden MG. Seeing the Warburg effect in the developing retina Nature Cell Biology. 14: 790-791. PMID 22854814 DOI: 10.1038/ncb2554  0.92
2012 Hvid H, Fendt SM, Blouin MJ, Birman E, Voisin G, Svendsen AM, Frank R, Vander Heiden MG, Stephanopoulos G, Hansen BF, Pollak M. Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway. Endocrine-Related Cancer. 19: 557-74. PMID 22685267 DOI: 10.1530/ERC-12-0125  0.92
2012 Lyssiotis CA, Vander-Heiden MG, Heiden MG, Muñoz-Pinedo C, Emerling BM. Emerging concepts: linking hypoxic signaling and cancer metabolism. Cell Death & Disease. 3: e303. PMID 22552280 DOI: 10.1038/cddis.2012.41  0.48
2012 Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149: 49-62. PMID 22401813 DOI: 10.1016/j.cell.2012.02.030  0.92
2012 Andronesi OC, Kim GS, Gerstner E, Batchelor T, Tzika AA, Fantin VR, Vander Heiden MG, Sorensen AG. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy Science Translational Medicine. 4. PMID 22238332 DOI: 10.1126/scitranslmed.3002693  0.92
2012 Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/nature10602  0.92
2012 Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology. 4: 79-87. PMID 22044881 DOI: 10.1093/jmcb/mjr030  0.92
2012 Davidson SM, Vander Heiden MG. METabolic adaptations in the tumor MYCroenvironment Cell Metabolism. 15: 131-133. DOI: 10.1016/j.cmet.2012.01.005  0.92
2012 Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth Biomedical Research. 23: 213-217.  0.92
2011 Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harbor Symposia On Quantitative Biology. 76: 325-34. PMID 22262476 DOI: 10.1101/sqb.2012.76.010900  0.92
2011 Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (New York, N.Y.). 334: 1278-83. PMID 22052977 DOI: 10.1126/science.1211485  0.92
2011 Lunt SY, Vander Heiden MG. Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation Annual Review of Cell and Developmental Biology. 27: 441-464. PMID 21985671 DOI: 10.1146/annurev-cellbio-092910-154237  0.92
2011 Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell & Melanoma Research. 24: 1112-5. PMID 21981974 DOI: 10.1111/j.1755-148X.2011.00919.x  0.92
2011 Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas CJ, Boxer MB. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 21: 6322-7. PMID 21958545 DOI: 10.1016/j.bmcl.2011.08.114  0.92
2011 Vander Heiden MG. Targeting cancer metabolism: A therapeutic window opens Nature Reviews Drug Discovery. 10: 671-684. PMID 21878982 DOI: 10.1038/nrd3504  0.92
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/j.cell.2011.06.050  0.92
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Vander Heiden MG, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/ng.890  0.92
2010 Metallo CM, Vander Heiden MG. Metabolism strikes back: Metabolic flux regulates cell signaling Genes and Development. 24: 2717-2722. PMID 21159812 DOI: 10.1101/gad.2010510  0.92
2010 Locasale JW, Vander Heiden MG, Cantley LC. Rewiring of glycolysis in cancer cell metabolism. Cell Cycle (Georgetown, Tex.). 9: 4253. PMID 21045562 DOI: 10.4161/cc.9.21.13925  0.92
2010 Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 329: 1492-9. PMID 20847263 DOI: 10.1126/science.1188015  0.92
2010 Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell. 39: 171-83. PMID 20670887 DOI: 10.1016/j.molcel.2010.06.022  0.92
2010 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Vander Heiden MG, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 465: 966. PMID 20559394 DOI: 10.1038/nature09132  0.92
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/j.molcel.2010.05.007  0.92
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/j.molcel.2010.05.007  0.92
2010 Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F, et al. The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle (Georgetown, Tex.). 9: 1960-71. PMID 20495363 DOI: 10.4161/cc.9.10.11601  0.92
2010 Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F, et al. The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle (Georgetown, Tex.). 9: 1960-71. PMID 20495363 DOI: 10.4161/cc.9.10.11601  0.92
2010 Vander Heiden MG. Targeting cell metabolism in cancer patients Science Translational Medicine. 2: 31ed1. PMID 20463364 DOI: 10.1126/scitranslmed.3001210  0.92
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/j.bmcl.2010.04.015  0.92
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/j.bmcl.2010.04.015  0.92
2010 Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 1894-9. PMID 20133837 DOI: 10.1073/pnas.0914845107  0.92
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/jm901577g  0.92
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/jm901577g  0.92
2010 Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79: 1118-24. PMID 20005212 DOI: 10.1016/j.bcp.2009.12.003  0.92
2010 Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79: 1118-24. PMID 20005212 DOI: 10.1016/j.bcp.2009.12.003  0.92
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Vander Heiden MG, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/nature08617  0.92
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Vander Heiden MG, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/nature08617  0.92
2009 Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling. 2: ra73. PMID 19920251 DOI: 10.1126/scisignal.2000431  0.92
2009 Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling. 2: ra73. PMID 19920251 DOI: 10.1126/scisignal.2000431  0.92
2009 Locasale JW, Cantley LC, Vander Heiden MG. Cancer's insatiable appetite. Nature Biotechnology. 27: 916-7. PMID 19816448 DOI: 10.1038/nbt1009-916  0.92
2009 Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (New York, N.Y.). 324: 1029-33. PMID 19460998 DOI: 10.1126/science.1160809  0.92
2009 Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, et al. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (New York, N.Y.). 324: 626-31. PMID 19407199 DOI: 10.1126/science.1165069  0.92
2008 Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452: 230-3. PMID 18337823 DOI: 10.1038/nature06734  0.92
2008 Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452: 230-3. PMID 18337823 DOI: 10.1038/nature06734  0.92
2008 Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature. 452: 181-186. PMID 18337815 DOI: 10.1038/nature06667  0.92
2008 Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature. 452: 181-186. PMID 18337815 DOI: 10.1038/nature06667  0.52
2003 McDonnell MA, Wang D, Khan SM, Vander Heiden MG, Kelekar A. Caspase-9 is activated in a cytochrome c-independent manner early during TNFα-induced apoptosis in murine cells Cell Death and Differentiation. 10: 1005-1015. PMID 12934075 DOI: 10.1038/sj.cdd.4401271  0.92
2002 Vander Heiden MG, Choy JS, VanderWeele DJ, Brace JL, Harris MH, Bauer DE, Prange B, Kron SJ, Thompson CB, Rudin CM. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. The Journal of Biological Chemistry. 277: 44870-6. PMID 12244097 DOI: 10.1074/jbc.M204888200  0.92
2002 Vander Heiden MG, Choy JS, VanderWeele DJ, Brace JL, Harris MH, Bauer DE, Prange B, Kron SJ, Thompson CB, Rudin CM. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. The Journal of Biological Chemistry. 277: 44870-6. PMID 12244097 DOI: 10.1074/jbc.M204888200  0.92
2002 Zhou R, Vander Heiden MG, Rudin CM. Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Research. 62: 3515-20. PMID 12067998  0.92
2002 Zhou R, Vander Heiden MG, Rudin CM. Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Research. 62: 3515-20. PMID 12067998  0.92
2001 Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism Molecular and Cellular Biology. 21: 5899-5912. PMID 11486029 DOI: 10.1128/MCB.21.17.5899-5912.2001  0.92
2001 Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism Molecular and Cellular Biology. 21: 5899-5912. PMID 11486029 DOI: 10.1128/MCB.21.17.5899-5912.2001  0.92
2001 Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M. Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. The Journal of Biological Chemistry. 276: 19414-9. PMID 11259441 DOI: 10.1074/jbc.M101590200  0.92
2001 Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M. Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. The Journal of Biological Chemistry. 276: 19414-9. PMID 11259441 DOI: 10.1074/jbc.M101590200  0.92
2000 Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Molecular Cell. 6: 683-92. PMID 11030347  0.52
2000 Chuang E, Fisher TS, Morgan RW, Robbins MD, Duerr JM, Vander Heiden MG, Gardner JP, Hambor JE, Neveu MJ, Thompson CB. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A Immunity. 13: 313-322. PMID 11021529  0.92
2000 Chuang E, Fisher TS, Morgan RW, Robbins MD, Duerr JM, Vander Heiden MG, Gardner JP, Hambor JE, Neveu MJ, Thompson CB. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A Immunity. 13: 313-322. PMID 11021529  0.92
2000 Chandel NS, Vander Heiden MG, Thompson CB, Schumacker PT. Redox regulation of p53 during hypoxia Oncogene. 19: 3840-3848. PMID 10951577  0.92
2000 Gottlieb E, Vander Heiden MG, Thompson CB. Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis Molecular and Cellular Biology. 20: 5680-5689. PMID 10891504 DOI: 10.1128/MCB.20.15.5680-5689.2000  0.92
2000 Gottlieb E, Vander Heiden MG, Thompson CB. Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis Molecular and Cellular Biology. 20: 5680-5689. PMID 10891504 DOI: 10.1128/MCB.20.15.5680-5689.2000  0.92
2000 Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M, Thompson CB. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proceedings of the National Academy of Sciences of the United States of America. 97: 4666-71. PMID 10781072 DOI: 10.1073/pnas.090082297  0.92
2000 Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M, Thompson CB. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proceedings of the National Academy of Sciences of the United States of America. 97: 4666-71. PMID 10781072 DOI: 10.1073/pnas.090082297  0.92
2000 Harris MH, Vander Heiden MG, Kron SJ, Thompson CB. Role of oxidative phosphorylation in Bax toxicity Molecular and Cellular Biology. 20: 3590-3596. PMID 10779348 DOI: 10.1128/MCB.20.10.3590-3596.2000  0.92
2000 Harris MH, Vander Heiden MG, Kron SJ, Thompson CB. Role of oxidative phosphorylation in Bax toxicity Molecular and Cellular Biology. 20: 3590-3596. PMID 10779348 DOI: 10.1128/MCB.20.10.3590-3596.2000  0.92
1999 Thompson CB, Rathmell JC, Frauwirth KA, Lindsten T, Rudin CM, Opferman JT, Ashton-Rickardt PG, Harris MH, Chandel NS, Schumacker PT, Vander Heiden MG. What keeps a resting T cell alive? Cold Spring Harbor Symposia On Quantitative Biology. 64: 383-7. PMID 11232311  0.92
1999 Thompson CB, Rathmell JC, Frauwirth KA, Lindsten T, Rudin CM, Opferman JT, Ashton-Rickardt PG, Harris MH, Chandel NS, Schumacker PT, Vander Heiden MG. What keeps a resting T cell alive? Cold Spring Harbor Symposia On Quantitative Biology. 64: 383-7. PMID 11232311  0.92
1999 Vander Heiden MG, Thompson CB. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis? Nature Cell Biology. 1: E209-E216. PMID 10587660  0.92
1999 Vander Heiden MG, Thompson CB. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis? Nature Cell Biology. 1: E209-E216. PMID 10587660  0.92
1999 Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB. Bcl-x(L) prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange Molecular Cell. 3: 159-167. PMID 10078199 DOI: 10.1016/S1097-2765(00)80307-X  0.92
1999 Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB. Bcl-x(L) prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange Molecular Cell. 3: 159-167. PMID 10078199 DOI: 10.1016/S1097-2765(00)80307-X  0.92
1999 Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB. Bcl-x(L) regulates apoptosis by heterodimerization-dependent and -independent mechanisms Embo Journal. 18: 632-643. PMID 9927423 DOI: 10.1093/emboj/18.3.632  0.92
1999 Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB. Bcl-x(L) regulates apoptosis by heterodimerization-dependent and -independent mechanisms Embo Journal. 18: 632-643. PMID 9927423 DOI: 10.1093/emboj/18.3.632  0.92
1999 Thompson CB, Vander Heiden M, Chang BS, Minn AJ, Sattler M, Liang H, Muchmore SW, Fesik SW. Role of Bcl-2 family members in apoptotic cell death Kidney International. 56: 1192.  0.92
1997 Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria Cell. 91: 627-637. PMID 9393856  0.92
1997 Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria Cell. 91: 627-637. PMID 9393856  0.92
1997 Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the Clathrin-Associated Protein AP50 Results in Ligand-Independent Endocytosis That Limits Cell Surface Expression Journal of Immunology. 159: 144-151. PMID 9200449  0.92
1997 Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the Clathrin-Associated Protein AP50 Results in Ligand-Independent Endocytosis That Limits Cell Surface Expression Journal of Immunology. 159: 144-151. PMID 9200449  0.92
1997 Thompson CB, Vander Heiden M, Chang BS, Minn AJ, Sattler M, Liang H, Muchmore SW, Fesik SW. The role of BCL-2 family members in apoptotic cell death Experimental Hematology. 25: 795.  0.92
1994 Baerson SR, Vander Heiden MG, Lamppa GK. Identification of domains in an Arabidopsis acyl carrier protein gene promoter required for maximal organ-specific expression Plant Molecular Biology. 26: 1947-1959. PMID 7858229 DOI: 10.1007/BF00019505  0.92
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