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Michael B. Yaffe - Publications

Biology  Massachusetts Institute of Technology, Cambridge, MA, United States 
Signaling and Systems Biology

221 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cahill LA, Joughin BA, Kwon WY, Itagaki K, Kirk CH, Shapiro NI, Otterbein LE, Yaffe MB, Lederer JA, Hauser CJ. Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper. Annals of Surgery. 272: 604-610. PMID 32932316 DOI: 10.1097/Sla.0000000000004379  0.36
2020 Krismer K, Bird MA, Varmeh S, Handly ED, Gattinger A, Bernwinkler T, Anderson DA, Heinzel A, Joughin BA, Kong YW, Cannell IG, Yaffe MB. Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression. Cell Reports. 32: 108064. PMID 32846122 DOI: 10.1016/J.Celrep.2020.108064  0.4
2020 Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR. Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model. Journal of Thrombosis and Haemostasis : Jth. PMID 32367690 DOI: 10.1111/Jth.14875  0.32
2019 Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, et al. Substrate-based kinase activity inference identifies MK2 as driver of colitis. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31617572 DOI: 10.1093/Intbio/Zyz025  0.36
2019 Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB. VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Cell Systems. PMID 31302152 DOI: 10.1016/J.Cels.2019.05.009  0.36
2019 Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB. ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest. Cell Systems. PMID 30797774 DOI: 10.1016/J.Cels.2019.01.005  0.36
2019 Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes. Cancer Research. PMID 30755444 DOI: 10.1158/0008-5472.Can-18-1604  0.4
2019 Kooij Bvd, Creixell P, Vlimmeren Av, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Author response: Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs Elife. DOI: 10.7554/Elife.44635.025  0.36
2018 Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nature Communications. 9: 1991. PMID 29777137 DOI: 10.1038/S41467-018-04315-4  0.4
2018 Dreaden EC, Kong YW, Quadir MA, Correa S, Suárez-López L, Barberio AE, Hwang MK, Shi AC, Oberlton B, Gallagher PN, Shopsowitz KE, Elias KM, Yaffe MB, Hammond PT. RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors. Bioengineering & Translational Medicine. 3: 26-36. PMID 29376131 DOI: 10.1002/btm2.10086  0.4
2017 Dayma Y, Yaffe MB. Abstract 52: Dynamic rewiring of apoptotic signaling networks by combined EGFR/FRGR inhibition enhances killing of head and neck squamous tumor by DNA damage Clinical Cancer Research. 23: 52-52. DOI: 10.1158/1557-3265.Aacrahns17-52  0.4
2016 Lee MJ, Yaffe MB. Protein Regulation in Signal Transduction. Cold Spring Harbor Perspectives in Biology. 8. PMID 27252361 DOI: 10.1101/Cshperspect.A005918  0.8
2016 Lam FC, Yaffe MB. Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma. Cancer Cell. 29: 435-6. PMID 27070697 DOI: 10.1016/J.Ccell.2016.03.022  0.8
2016 Barrett CD, Yaffe MB. Neutrophils, inflammation, and innate immunity in trauma-induced coagulopathy Trauma Induced Coagulopathy. 149-165. DOI: 10.1007/978-3-319-28308-1_10  0.8
2015 Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. PMID 26602816 DOI: 10.1016/j.ccell.2015.09.009  0.8
2015 Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT. Tumor-Targeted Synergistic Blockade of MAPK and PI3K From a Layer-by-Layer Nanoparticle. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26034127 DOI: 10.1158/1078-0432.Ccr-15-0013  0.8
2015 Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock (Augusta, Ga.). 44: 128-36. PMID 26009816 DOI: 10.1097/Shk.0000000000000386  0.8
2015 Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. Journal of Biomolecular Screening. PMID 25918037 DOI: 10.1177/1087057115583037  0.8
2015 Ehrenberger T, Cantley LC, Yaffe MB. Computational prediction of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 1278: 57-75. PMID 25859943 DOI: 10.1007/978-1-4939-2425-7_4  0.56
2015 Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM. Engineered bromodomains to explore the acetylproteome. Proteomics. 15: 1470-5. PMID 25641834 DOI: 10.1002/Pmic.201400401  0.56
2015 Lee MJ, Dayma Y, Heijinks A, Morton SW, Dreaden EC, Hammond PT, Yaffe MB. Abstract SY19-01: Therapeutic network re-wiring of the DNA damage response can be used to enhance tumor killing by cytotoxic chemotherapy Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy19-01  0.4
2015 Naegle K, Gough NR, Yaffe MB. Criteria for biological reproducibility: What does "n" mean? Science Signaling. 8. DOI: 10.1126/scisignal.aab1125  0.8
2015 Yaffe MB. Reproducibility in science Science Signaling. 8. DOI: 10.1126/scisignal.aaa5764  0.8
2014 Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells. Biopolymers. 102: 444-55. PMID 25283071 DOI: 10.1002/Bip.22569  0.8
2014 Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 158: 1094-109. PMID 25171410 DOI: 10.1016/J.Cell.2014.07.032  0.8
2014 Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, ... ... Yaffe MB, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 26: 222-34. PMID 25117710 DOI: 10.1016/J.Ccr.2014.06.026  0.8
2014 Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Science Signaling. 7: ra44. PMID 24825919 DOI: 10.1126/Scisignal.2005261  0.8
2014 Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH. Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation Cell Death and Differentiation. 21: 854-863. PMID 24510127 DOI: 10.1038/cdd.2014.8  0.8
2013 Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response InVivo Cell Reports. 5: 868-877. PMID 24239348 DOI: 10.1016/J.Celrep.2013.10.025  0.8
2013 Qian WJ, Park JE, Lim D, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Peptide-based inhibitors of plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs Chemistry and Biology. 20: 1255-1264. PMID 24120332 DOI: 10.1016/J.Chembiol.2013.09.005  0.8
2013 Christian Reinhardt H, Yaffe MB. Phospho-Ser/Thr-binding domains: Navigating the cell cycle and DNA damage response Nature Reviews Molecular Cell Biology. 14: 563-580. PMID 23969844 DOI: 10.1038/Nrm3640  0.8
2013 Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (New York, N.Y.). 341: 1236566. PMID 23888043 DOI: 10.1126/Science.1236566  0.8
2013 Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, ... ... Yaffe MB, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 498: 246-50. PMID 23728299 DOI: 10.1038/Nature12147  0.8
2013 Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 940-63. PMID 23685806 DOI: 10.1039/C3Ib40013A  0.8
2013 Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR, Winey M, Smerdon SJ, Yaffe MB, Amon A. Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science (New York, N.Y.). 340: 871-5. PMID 23579499 DOI: 10.1126/Science.1235822  0.8
2013 Yaffe MB. The scientific drunk and the lamppost: Massive sequencing efforts in cancer discovery and treatment Science Signaling. 6: pe13. PMID 23550209 DOI: 10.1126/Scisignal.2003684  0.8
2013 Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1 Bioorganic and Medicinal Chemistry. 21: 2623-2634. PMID 23498919 DOI: 10.1016/J.Bmc.2013.02.020  0.8
2013 Weingeist DM, Ge J, Wood DK, Mutamba JT, Huang Q, Rowland EA, Yaffe MB, Floyd S, Engelward BP. Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle (Georgetown, Tex.). 12: 907-15. PMID 23422001 DOI: 10.4161/Cc.23880  0.8
2013 Yaffe MB, Gough NR. 2012: Signaling breakthroughs of the year Science Signaling. 6. PMID 23281367 DOI: 10.1126/Scisignal.2003881  0.8
2013 Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JPJ. Structure of the toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence Journal of Biological Chemistry. 288: 34968-34980. DOI: 10.1074/jbc.M113.523266  0.8
2012 Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proceedings of the National Academy of Sciences of the United States of America. 109: 14381-6. PMID 22908299 DOI: 10.1073/Pnas.1212366109  0.8
2012 Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1237-55. PMID 22892544 DOI: 10.1039/C2Ib20091K  0.32
2012 Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2574-83. PMID 22889908 DOI: 10.1098/Rstb.2012.0010  0.8
2012 Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Molecular Biosystems. 8: 2771-82. PMID 22851037 DOI: 10.1039/C2Mb25200G  0.8
2012 Morandell S, Yaffe MB. Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy Progress in Molecular Biology and Translational Science. 110: 289-314. PMID 22749150 DOI: 10.1016/B978-0-12-387665-2.00011-0  0.8
2012 Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 149: 780-94. PMID 22579283 DOI: 10.1016/J.Cell.2012.03.031  0.8
2012 Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1 Chembiochem. 13: 1291-1296. PMID 22570300 DOI: 10.1002/Cbic.201200206  0.8
2012 Kholodenko B, Yaffe MB, Kolch W. Computational approaches for analyzing information flow in biological networks Science Signaling. 5. PMID 22510471 DOI: 10.1126/Scisignal.2002961  0.8
2012 Mohammad DH, Yaffe MB. Fixin' to Divide Molecular Cell. 45: 273-275. PMID 22325348 DOI: 10.1016/J.Molcel.2012.01.022  0.8
2012 Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Molecular Systems Biology. 8: 568. PMID 22294094 DOI: 10.1038/Msb.2012.1  0.8
2012 Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification Acs Chemical Biology. 7: 805-810. PMID 22292814 DOI: 10.1021/Cb200469A  0.8
2012 Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, et al. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proceedings of the National Academy of Sciences of the United States of America. 109: 929-34. PMID 22223660 DOI: 10.1073/Pnas.1115528109  0.8
2011 Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell. 44: 878-92. PMID 22137581 DOI: 10.1016/J.Molcel.2011.11.005  0.68
2011 Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, Yaffe MB, Strano S, Blandino G, Di Agostino S. Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop Cell Cycle. 10: 4330-4340. PMID 22134238 DOI: 10.4161/Cc.10.24.18682  0.8
2011 Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, et al. Systematic phosphorylation analysis of human mitotic protein complexes. Science Signaling. 4: rs12. PMID 22067460 DOI: 10.1126/Scisignal.2001993  0.8
2011 Gardino AK, Yaffe MB. 14-3-3 proteins as signaling integration points for cell cycle control and apoptosis Seminars in Cell and Developmental Biology. 22: 688-695. PMID 21945648 DOI: 10.1016/J.Semcdb.2011.09.008  0.8
2011 Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Molecular & Cellular Proteomics : McP. 10: M111.008540. PMID 21857030 DOI: 10.1074/Mcp.M111.008540  0.8
2011 Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets. Plos Computational Biology. 7: e1002119. PMID 21799663 DOI: 10.1371/Journal.Pcbi.1002119  0.8
2011 Liu F, Park JE, Qian WJ, Lim D, Gräber M, Berg T, Yaffe MB, Lee KS, Burke TR. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel Nature Chemical Biology. 7: 595-601. PMID 21765407 DOI: 10.1038/Nchembio.614  0.8
2011 Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JRA, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, ... ... Yaffe MB, et al. Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling Science Signaling. 4. PMID 21712545 DOI: 10.1126/Scisignal.2001796  0.8
2011 Cannell IG, Yaffe MB. Salvaging the septic heart through targeting the interleukin-6/p38 mitogen-activated protein kinase signaling network Critical Care Medicine. 39: 1836-1837. PMID 21685754 DOI: 10.1097/Ccm.0B013E3182204Ad1  0.8
2011 Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (New York, N.Y.). 332: 1317-22. PMID 21659604 DOI: 10.1126/Science.1199498  0.8
2011 Gough NR, Yaffe MB. Focus issue: Conquering the data mountain Science Signaling. 4. PMID 21325201 DOI: 10.1126/Scisignal.2001871  0.8
2011 Reinhardt HC, Cannell IG, Morandell S, Yaffe MB. Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle. 10: 23-27. PMID 21173571 DOI: 10.4161/Cc.10.1.14351  0.8
2011 Yaffe MB. The complex art of telling it simply Science Signaling. 4. DOI: 10.1126/Scisignal.2002710  0.8
2011 Yaffe MB, VanHook AM. Podcasts - Science Signaling Podcast: 4 January 2011 Science Signaling. 4. DOI: 10.1126/Scisignal.2001786  0.8
2011 Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome Molecular and Cellular Proteomics. 10. DOI: 10.1074/mcp.M111.008540  0.8
2010 Pennell S, Westcott S, Ortiz-Lombardía M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ. Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure (London, England : 1993). 18: 1587-95. PMID 21134638 DOI: 10.1016/J.Str.2010.09.014  0.8
2010 Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Molecular Cell. 40: 34-49. PMID 20932473 DOI: 10.1016/J.Molcel.2010.09.018  0.8
2010 Yaffe MB. Looking ahead to the past Science Signaling. 3: eg7. PMID 20823400 DOI: 10.1126/Scisignal.3138Eg7  0.8
2010 Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Molecular & Cellular Proteomics : McP. 9: 2558-70. PMID 20631208 DOI: 10.1074/Mcp.M110.001206  0.8
2010 Van Vugt MATM, Yaffe MB. Cell cycle re-entry mechanisms after DNA damage checkpoints: Giving it some gas to shut off the breaks! Cell Cycle. 9: 2097-2101. PMID 20505366 DOI: 10.4161/Cc.9.11.11840  0.8
2010 Jeong H, Bae S, An SY, Byun MR, Hwang JH, Yaffe MB, Hong JH, Hwang ES. TAZ as a novel enhancer of MyoD-mediated myogenic differentiation Faseb Journal. 24: 3310-3320. PMID 20466877 DOI: 10.1096/Fj.09-151324  0.8
2010 Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Research. 70: 3843-50. PMID 20406974 DOI: 10.1158/0008-5472.Can-09-3421  0.8
2010 van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, ... Yaffe MB, et al. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. Plos Biology. 8: e1000287. PMID 20126263 DOI: 10.1371/Journal.Pbio.1000287  0.8
2010 Wen J, Wilker EW, Yaffe MB, Jensen KF. Microfluidic preparative free-flow isoelectric focusing: system optimization for protein complex separation. Analytical Chemistry. 82: 1253-60. PMID 20092256 DOI: 10.1021/Ac902157E  0.8
2010 Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M. Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of gli with 14-3-3 Journal of Biological Chemistry. 285: 4185-4194. PMID 19996099 DOI: 10.1074/Jbc.M109.038232  0.8
2010 Jiang Y, Puliyappadamba VT, Zhang L, Wu W, Wali A, Yaffe MB, Fontana JA, Rishi AK. A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 Journal of Molecular Signaling. 5. DOI: 10.1186/1750-2187-5-7  0.8
2010 Yaffe MB, Vanhook AM. Science signaling podcast: 5 January 2010 Science Signaling. 3: pc1. DOI: 10.1126/Scisignal.3103Pc1  0.8
2010 Ellson CD, Yaffe MB. PX domains Handbook of Cell Signaling, 2/E. 2: 1103-1109. DOI: 10.1016/B978-0-12-374145-5.00137-6  0.8
2010 Smerdon SJ, Yaffe MB. Recognition of phospho-serine/threonine phosphorylated proteins by phospho-serine/threonine-binding domains Handbook of Cell Signaling, 2/E. 2: 539-550. DOI: 10.1016/B978-0-12-374145-5.00072-3  0.8
2009 Yaffe MB. Living by the numbers Science Signaling. 2: eg15. PMID 19952368 DOI: 10.1126/Scisignal.299Eg15  0.8
2009 Blandino G, Shaul Y, Strano S, Sudol M, Yaffe M. The hippo tumor suppressor pathway: A brainstorming workshop Science Signaling. 2: mr6. PMID 19887678 DOI: 10.1126/Scisignal.295Mr6  0.8
2009 Christian Reinhardt H, Jiang H, Hemann MT, Yaffe MB. Exploiting synthetic lethal interactions for targeted cancer therapy Cell Cycle. 8: 3112-3119. PMID 19755856 DOI: 10.4161/Cc.8.19.9626  0.8
2009 Yaffe MB. Re-reviewing peer review Science Signaling. 2: eg11. PMID 19706869 DOI: 10.1126/Scisignal.285Eg11  0.8
2009 Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis and Rheumatism. 60: 2314-24. PMID 19644878 DOI: 10.1002/Art.24704  0.8
2009 Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT. The combined status of ATM and p53 link tumor development with therapeutic response Genes and Development. 23: 1895-1909. PMID 19608766 DOI: 10.1101/Gad.1815309  0.8
2009 Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, ... ... Yaffe MB, et al. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1 Nature Structural and Molecular Biology. 16: 876-882. PMID 19597481 DOI: 10.1038/Nsmb.1628  0.8
2009 Yaffe MB. Challenging times Science Signaling. 2: eg8. PMID 19567911 DOI: 10.1126/scisignal.277eg8  0.8
2009 Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Molecular Cancer Therapeutics. 8: 1666-75. PMID 19509266 DOI: 10.1158/1535-7163.Mct-08-1012  0.8
2009 Mohammad DH, Yaffe MB. 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response Dna Repair. 8: 1009-1017. PMID 19481982 DOI: 10.1016/J.Dnarep.2009.04.004  0.8
2009 van Leuken R, Clijsters L, van Zon W, Lim D, Yao XB, Wolthuis RMF, Yaffe MB, Medema RH, van Vugt MATM. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1 Plos One. 4. PMID 19390576 DOI: 10.1371/Journal.Pone.0005282  0.8
2009 Kishi K, Van Vugt MATM, Okamoto KI, Hayashi Y, Yaffe MB. Functional dynamics of polo-like kinase 1 at the centrosome Molecular and Cellular Biology. 29: 3134-3150. PMID 19307309 DOI: 10.1128/Mcb.01663-08  0.8
2009 Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2 Current Opinion in Cell Biology. 21: 245-255. PMID 19230643 DOI: 10.1016/J.Ceb.2009.01.018  0.8
2009 Yaffe MB. Freedom of materials Science Signaling. 2: eg2. PMID 19176512 DOI: 10.1126/Scisignal.255Eg2  0.8
2009 Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G. Distinct mechanisms act in concert to mediate cell cycle arrest Proceedings of the National Academy of Sciences of the United States of America. 106: 785-790. PMID 19139404 DOI: 10.1073/Pnas.0806196106  0.8
2009 Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM. An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells. Molecular Biosystems. 5: 59-67. PMID 19081932 DOI: 10.1039/B815075C  0.8
2009 Edbauer D, Cheng D, Batterton MN, Wang CF, Duong DM, Yaffe MB, Peng J, Sheng M. Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Molecular & Cellular Proteomics : McP. 8: 681-95. PMID 19054758 DOI: 10.1074/Mcp.M800233-Mcp200  0.8
2009 Ostheimer GJ, Lauffenburger DA, Yaffe MB. Abstract B73: To sleep or die: Cell fate after chemotherapy Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-B73  0.32
2009 Yaffe MB, VanHook AM. Science signaling podcast: 28 July 2009 Science Signaling. 2: pc14. DOI: 10.1126/Scisignal.281Pc14  0.8
2009 Yaffe MB, VanHook AM. Science signaling podcast: 21 April 2009 Science Signaling. 2: pc8. DOI: 10.1126/Scisignal.267Pc8  0.8
2008 Yaffe MB. Beyond microarrays Science Signaling. 1: eg11. PMID 19109235 DOI: 10.1126/scisignal.151eg11  0.8
2008 Yaffe MB. How to "cell" a Genomic or Proteomic Screen Science Signaling. 1: eg9. PMID 19036710 DOI: 10.1126/Scisignal.147Eg9  0.8
2008 Yaffe MB. Signaling networks and mathematics. Science Signaling. 1: eg7. PMID 18957689 DOI: 10.1126/Scisignal.143Eg7  0.8
2008 Janes KA, Reinhardt HC, Yaffe MB. Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell. 135: 343-54. PMID 18957207 DOI: 10.1016/J.Cell.2008.08.034  0.8
2008 Yi C, Wilker EW, Yaffe MB, Stemmer-Rachamimov A, Kissil JL. Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2 Cancer Research. 68: 7932-7937. PMID 18829550 DOI: 10.1158/0008-5472.Can-08-0866  0.8
2008 Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, ... ... Yaffe MB, et al. Linear motif atlas for phosphorylation-dependent signaling. Science Signaling. 1: ra2. PMID 18765831 DOI: 10.1126/Scisignal.1159433  0.8
2008 Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM, Yaffe M, Weiss EL. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. Plos Biology. 6: e203. PMID 18715118 DOI: 10.1371/Journal.Pbio.0060203  0.8
2008 Tian W, Li XJ, Stull ND, Ming W, Sun CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC. Fc{gamma}R-stimulated activation of the NADPH oxidase: Phosphoinositide- binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome Blood. 112: 3867-3877. PMID 18711001 DOI: 10.1182/Blood-2007-11-126029  0.8
2008 Mac?rek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery Nature. 455: 119-123. PMID 18615013 DOI: 10.1038/Nature07185  0.8
2008 Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nature Cell Biology. 10: 837-48. PMID 18568018 DOI: 10.1038/Ncb1748  0.8
2008 Bissonnette SA, Glazier CM, Stewart MQ, Brown GE, Ellson CD, Yaffe MB. Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase. The Journal of Biological Chemistry. 283: 2108-19. PMID 18029359 DOI: 10.1074/Jbc.M706639200  0.8
2008 Linding R, Jensen LJ, Pasculescu A, Olhovsky M, Colwill K, Bork P, Yaffe MB, Pawson T. NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Research. 36: D695-9. PMID 17981841 DOI: 10.1093/Nar/Gkm902  0.8
2008 Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks (DOI:10.1016/j.cell.2005.09.038) Cell. 133: 549. DOI: 10.1016/j.cell.2008.04.021  0.8
2008 Wen J, Albrecht J, Wilker EW, Yaffe MB, Jensen KF. Microfluidic protein separation by free flow isoelectric focusing 12th International Conference On Miniaturized Systems For Chemistry and Life Sciences - the Proceedings of Microtas 2008 Conference. 492-494.  0.8
2007 Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 131: 901-14. PMID 18001825 DOI: 10.1016/J.Cell.2007.09.041  0.8
2007 Dai S, Zhang Y, Weimbs T, Yaffe MB, Zhou D. Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic (Copenhagen, Denmark). 8: 1365-74. PMID 17645435 DOI: 10.1111/J.1600-0854.2007.00613.X  0.8
2007 Tian Y, Kolb R, Hong JH, Carroll J, Li D, You J, Bronson R, Yaffe MB, Zhou J, Benjamin T. TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Molecular and Cellular Biology. 27: 6383-95. PMID 17636028 DOI: 10.1128/Mcb.00254-07  0.8
2007 Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguyen V, Pasculescu A, Jin J, Park JG, ... ... Yaffe MB, et al. Systematic discovery of in vivo phosphorylation networks. Cell. 129: 1415-26. PMID 17570479 DOI: 10.1016/J.Cell.2007.05.052  0.8
2007 Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB. Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. The Embo Journal. 26: 2262-73. PMID 17446864 DOI: 10.1038/Sj.Emboj.7601683  0.8
2007 Wilker EW, van Vugt MA, Artim SA, Huang PH, Petersen CP, Reinhardt HC, Feng Y, Sharp PA, Sonenberg N, White FM, Yaffe MB. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 446: 329-32. PMID 17361185 DOI: 10.1038/Nature05584  0.8
2007 Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell. 11: 175-89. PMID 17292828 DOI: 10.1016/J.Ccr.2006.11.024  0.8
2007 Yaffe MB, White FM. Signaling netwErks get the global treatment. Genome Biology. 8: 202. PMID 17274840 DOI: 10.1186/Gb-2007-8-1-202  0.8
2006 Janes KA, Yaffe MB. Data-driven modelling of signal-transduction networks. Nature Reviews. Molecular Cell Biology. 7: 820-8. PMID 17057752 DOI: 10.1038/Nrm2041  0.8
2006 Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Research. 66: 7473-81. PMID 16885344 DOI: 10.1158/0008-5472.Can-06-1193  0.8
2006 Suh CI, Stull ND, Xing JL, Tian W, Price MO, Grinstein S, Yaffe MB, Atkinson S, Dinauer MC. The phosphoinositide-binding protein p40 phox activates the NADPH oxidase during FcγIIA receptor-induced phagocytosis Journal of Experimental Medicine. 203: 1915-1925. PMID 16880255 DOI: 10.1083/Jcb1744Oia8  0.8
2006 Cheng C, Yaffe MB, Sharp PA. A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes & Development. 20: 1715-20. PMID 16818603 DOI: 10.1101/Gad.1430906  0.8
2006 Yaffe MB. "Bits" and pieces Science's Stke : Signal Transduction Knowledge Environment. 2006: pe28. PMID 16788164 DOI: 10.1126/Stke.3402006Pe28  0.8
2006 Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y, Pellman D. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science (New York, N.Y.). 313: 108-11. PMID 16763112 DOI: 10.1126/Science.1126747  0.8
2006 Gardino AK, Smerdon SJ, Yaffe MB. Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Seminars in Cancer Biology. 16: 173-82. PMID 16678437 DOI: 10.1016/J.Semcancer.2006.03.007  0.8
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/Journal.Pbio.0040038  0.8
2006 Hong JH, Yaffe MB. A β-catenin-like molecule that regulates mesenchymal stem cell differentiation Cell Cycle. 5: 176-179. PMID 16397409 DOI: 10.4161/Cc.5.2.2362  0.8
2006 Nishikawa K, Watanabe M, Kita E, Igai K, Omata K, Yaffe MB, Natori Y. A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin Faseb Journal. 20: E2077-E2086. DOI: 10.1096/fj.06-6572fje  0.8
2005 Yaffe MB. X-ray crystallography and structural biology Critical Care Medicine. 33: S435-S440. PMID 16340415 DOI: 10.1097/01.Ccm.0000191719.66383.01  0.8
2005 Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (New York, N.Y.). 310: 1646-53. PMID 16339439 DOI: 10.1126/Science.1116598  0.8
2005 Macdonald N, Welburn JP, Noble ME, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Molecular Cell. 20: 199-211. PMID 16246723 DOI: 10.1016/J.Molcel.2005.08.032  0.8
2005 Mah AS, Elia AE, Devgan G, Ptacek J, Schutkowski M, Snyder M, Yaffe MB, Deshaies RJ. Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. Bmc Biochemistry. 6: 22. PMID 16242037 DOI: 10.1186/1471-2091-6-22  0.8
2005 Russ WP, Lowery DM, Mishra P, Yaffe MB, Ranganathan R. Natural-like function in artificial WW domains. Nature. 437: 579-83. PMID 16177795 DOI: 10.1038/Nature03990  0.8
2005 Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309: 1074-8. PMID 16099986 DOI: 10.1126/Science.1110955  0.8
2005 Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Current Biology : Cb. 15: 1078-89. PMID 15964272 DOI: 10.1016/J.Cub.2005.05.026  0.8
2005 Wilker EW, Grant RA, Artim SC, Yaffe MB. A structural basis for 14-3-3sigma functional specificity. The Journal of Biological Chemistry. 280: 18891-8. PMID 15731107 DOI: 10.1074/Jbc.M500982200  0.8
2005 Lowery DM, Lim D, Yaffe MB. Structure and function of Polo-like kinases. Oncogene. 24: 248-59. PMID 15640840 DOI: 10.1038/Sj.Onc.1208280  0.8
2005 Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro Journal of Biological Chemistry. 280: 9780-9785. PMID 15640142 DOI: 10.1074/Jbc.M414080200  0.8
2005 Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, Yaffe MB. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Molecular Cell. 17: 37-48. PMID 15629715 DOI: 10.1016/J.Molcel.2004.11.021  0.8
2005 Mahoney WM, Hong JH, Yaffe MB, Farrance IKG. The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members Biochemical Journal. 388: 217-225. PMID 15628970 DOI: 10.1042/Bj20041434  0.8
2005 Joughin BA, Tidor B, Yaffe MB. A computational method for the analysis and prediction of protein: Phosphopeptide-binding sites Protein Science. 14: 131-139. PMID 15576564 DOI: 10.1110/Ps.04964705  0.8
2005 Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, ... ... Yaffe MB, et al. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. The Journal of Biological Chemistry. 280: 7519-29. PMID 15475363 DOI: 10.1074/Jbc.M407438200  0.8
2004 Yaffe MB. Novel at the library Nat Methods. 1: 13-14. PMID 15782146 DOI: 10.1038/Nmeth1004-13  0.8
2004 Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Developmental Cell. 7: 571-83. PMID 15469845 DOI: 10.1016/J.Devcel.2004.07.024  0.8
2004 Wilker E, Yaffe MB. 14-3-3 Proteins - A focus on cancer and human disease Journal of Molecular and Cellular Cardiology. 37: 633-642. PMID 15350836 DOI: 10.1016/J.Yjmcc.2004.04.015  0.8
2004 Nguyen A, Rothman DM, Stehn J, Imperiali B, Yaffe MB. Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function. Nature Biotechnology. 22: 993-1000. PMID 15273693 DOI: 10.1038/Nbt997  0.8
2004 Yaffe MB, Smerdon SJ. The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function Annual Review of Biophysics and Biomolecular Structure. 33: 225-244. PMID 15139812 DOI: 10.1146/Annurev.Biophys.33.110502.133346  0.8
2004 Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer Nature Structural and Molecular Biology. 11: 512-518. PMID 15133502 DOI: 10.1038/Nsmb775  0.8
2004 Dalal SN, Yaffe MB, DeCaprio JA. 14-3-3 Family members act coordinately to regulate mitotic progression Cell Cycle. 3: 672-677. PMID 15107609 DOI: 10.4161/Cc.3.5.856  0.8
2004 Brown GE, Stewart MQ, Bissonnette SA, Elia AE, Wilker E, Yaffe MB. Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. The Journal of Biological Chemistry. 279: 27059-68. PMID 15102856 DOI: 10.1074/Jbc.M314258200  0.8
2004 Obenauer JC, Yaffe MB. Computational prediction of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 261: 445-68. PMID 15064475 DOI: 10.1385/1-59259-762-9:445  0.8
2004 Yaffe MB. Master of all things phosphorylated The Biochemical Journal. 379: e1-2. PMID 15061704 DOI: 10.1042/Bj20040284  0.8
2004 Park KS, Whitsett JA, Di Palma T, Hong JH, Yaffe MB, Zannini M. TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. The Journal of Biological Chemistry. 279: 17384-90. PMID 14970209 DOI: 10.1074/Jbc.M312569200  0.8
2004 Yaffe MB. Study of substrate specificity of MAPKs using oriented peptide libraries Methods in Molecular Biology (Clifton, N.J.). 250: 237-250. PMID 14755092 DOI: 10.1385/1-59259-671-1:237  0.8
2004 Lowery DM, Mohammad DH, Elia AE, Yaffe MB. The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function. Cell Cycle (Georgetown, Tex.). 3: 128-31. PMID 14712072  0.8
2003 Endy D, Yaffe MB. Molecular monogamy Nature. 426: 614-615. PMID 14668845 DOI: 10.1038/426614A  0.8
2003 Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Molecular Cell. 12: 841-9. PMID 14580336 DOI: 10.1016/S1097-2765(03)00382-4  0.8
2003 Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science (New York, N.Y.). 302: 636-9. PMID 14576432 DOI: 10.1126/Science.1088877  0.8
2003 Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 115: 83-95. PMID 14532005 DOI: 10.1016/S0092-8674(03)00725-6  0.8
2003 Vázquez ME, Nitz M, Stehn J, Yaffe MB, Imperiali B. Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations. Journal of the American Chemical Society. 125: 10150-1. PMID 12926919 DOI: 10.1021/Ja0351847  0.8
2003 Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR. Proteomic identification of 14-3-3ζ as a mitogen-activated protein kinase-activated protein kinase 2 substrate: Role in dimer formation and ligand binding Molecular and Cellular Biology. 23: 5376-5387. PMID 12861023 DOI: 10.1128/Mcb.23.15.5376-5387.2003  0.8
2003 Yaffe MB. Studying the optimal peptide substrate motifs of protein kinase C using oriented peptide libraries Methods in Molecular Biology (Clifton, N.J.). 233: 273-285. PMID 12840514 DOI: 10.1385/1-59259-397-6:273  0.8
2003 Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & Cellular Proteomics : McP. 2: 463-73. PMID 12832460 DOI: 10.1074/Mcp.M300045-Mcp200  0.8
2003 Obenauer JC, Cantley LC, Yaffe MB. Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Research. 31: 3635-41. PMID 12824383 DOI: 10.1093/Nar/Gkg584  0.8
2003 Manke IA, Yaffe MB. Chk'n out in mitosis Cell Cycle (Georgetown, Tex.). 2: 236-237. PMID 12775938 DOI: 10.4161/Cc.2.3.405  0.8
2003 Elia AE, Cantley LC, Yaffe MB. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science (New York, N.Y.). 299: 1228-31. PMID 12595692 DOI: 10.1126/Science.1079079  0.8
2003 Nguyen A, Yaffe MB. Proteomics and systems biology approaches to signal transduction in sepsis. Critical Care Medicine. 31: S1-6. PMID 12544970 DOI: 10.1097/00003246-200301001-00001  0.8
2003 Brown GE, Stewart MQ, Liu H, Ha VL, Yaffe MB. A novel assay system implicates PtdIns(3,4)P2, PtdIns(3)P, and PKCδ in intracellular production of reactive oxygen species by the NADPH oxidase Molecular Cell. 11: 35-47. PMID 12535519 DOI: 10.1016/S1097-2765(03)00005-4  0.8
2002 Yaffe MB. The p47phox PX domain: Two heads are better than one! Structure. 10: 1288-1290. PMID 12377114 DOI: 10.1016/S0969-2126(02)00860-2  0.8
2002 Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ. Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Molecular Cell. 9: 1045-54. PMID 12049740 DOI: 10.1016/S1097-2765(02)00527-0  0.8
2002 Yaffe MB. Phosphotyrosine-binding domains in signal transduction Nature Reviews Molecular Cell Biology. 3: 177-186. PMID 11994738 DOI: 10.1038/Nrm759  0.8
2002 Yaffe MB. How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis Febs Letters. 513: 53-57. PMID 11911880 DOI: 10.1016/S0014-5793(01)03288-4  0.8
2002 Johnson BA, Stehn JR, Yaffe MB, Blackwell TK. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. The Journal of Biological Chemistry. 277: 18029-36. PMID 11886850 DOI: 10.1074/Jbc.M110465200  0.8
2002 Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. The Journal of Cell Biology. 156: 817-28. PMID 11864996 DOI: 10.1083/Jcb.200112059  0.8
2002 Yaffe MB. MAGUK SH3 domains-swapped and stranded by their kinases? Structure. 10: 3-5. PMID 11796103 DOI: 10.1016/S0969-2126(01)00705-5  0.8
2001 Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. The Embo Journal. 20: 5840-52. PMID 11689425 DOI: 10.1093/Emboj/20.21.5840  0.8
2001 He J, Lau AG, Yaffe MB, Hall RA. Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase. The Journal of Biological Chemistry. 276: 41559-65. PMID 11533036 DOI: 10.1074/Jbc.M106859200  0.8
2001 Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nature Cell Biology. 3: 675-8. PMID 11433300 DOI: 10.1038/35083070  0.8
2001 Yaffe MB, Smerdon SJ. PhosphoSerine/threonine binding domains: You can't pSERious? Structure. 9: R33-R38. PMID 11286893 DOI: 10.1016/S0969-2126(01)00580-9  0.8
2001 Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nature Biotechnology. 19: 348-53. PMID 11283593 DOI: 10.1038/86737  0.8
2001 Yaffe MB, Elia AE. Phosphoserine/threonine-binding domains. Current Opinion in Cell Biology. 13: 131-8. PMID 11248545 DOI: 10.1016/S0955-0674(00)00189-7  0.8
2000 Durocher D, Smerdon SJ, Yaffe MB, Jackson SP. The FHA domain in DNA repair and checkpoint signaling Cold Spring Harbor Symposia On Quantitative Biology. 65: 423-431. PMID 12760058 DOI: 10.1101/Sqb.2000.65.423  0.8
2000 Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. The Embo Journal. 19: 6778-91. PMID 11118213 DOI: 10.1093/Emboj/19.24.6778  0.8
2000 Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Molecular Cell. 6: 1169-82. PMID 11106755 DOI: 10.1016/S1097-2765(00)00114-3  0.8
2000 Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Molecular Cell. 6: 969-74. PMID 11090635 DOI: 10.1016/S1097-2765(05)00085-7  0.8
2000 Yaffe MB, Cantley LC. Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods in Enzymology. 328: 157-70. PMID 11075345 DOI: 10.1016/S0076-6879(00)28397-3  0.8
2000 Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Molecular Cell. 6: 41-51. PMID 10949026 DOI: 10.1016/S1097-2765(05)00012-2  0.8
2000 Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. The Journal of Biological Chemistry. 275: 36108-15. PMID 10945990 DOI: 10.1074/Jbc.M005497200  0.8
2000 Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. The Journal of Biological Chemistry. 275: 28167-72. PMID 10862767 DOI: 10.1074/Jbc.M002905200  0.32
2000 Obata T, Brown GE, Yaffe MB. MAP kinase pathways activated by stress: the p38 MAPK pathway. Critical Care Medicine. 28: 67-77. PMID 10807318 DOI: 10.1097/00003246-200004001-00008  0.32
2000 Yaffe MB, Fink MP. Cellular signaling in critical care - Putting the pieces together Critical Care Medicine. 28. PMID 10807311 DOI: 10.1097/00003246-200004001-00001  0.8
2000 Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. The Journal of Biological Chemistry. 275: 16030-6. PMID 10748127 DOI: 10.1074/Jbc.M909368199  0.8
2000 Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. The Journal of Biological Chemistry. 275: 10359-69. PMID 10744724 DOI: 10.1074/Jbc.275.14.10359  0.8
2000 Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. The Journal of Biological Chemistry. 275: 2219-30. PMID 10636929 DOI: 10.1074/Jbc.275.3.2219  0.8
1999 Yaffe MB, Cantley LC. Signal transduction. Grabbing phosphoproteins. Nature. 402: 30-1. PMID 10573413 DOI: 10.1038/46925  0.68
1999 Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Molecular Cell. 4: 555-61. PMID 10549287 DOI: 10.1016/S1097-2765(00)80206-3  0.8
1999 Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (New York, N.Y.). 285: 2129-33. PMID 10497131 DOI: 10.1126/Science.285.5436.2129  0.68
1999 Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Molecular Cell. 4: 153-66. PMID 10488331 DOI: 10.1016/S1097-2765(00)80363-9  0.68
1999 Yaffe MB, Xu J, Burke PA, Forse RA, Brown GE. Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation Surgery. 126: 248-254. PMID 10455891 DOI: 10.1016/S0039-6060(99)70162-5  0.8
1998 Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Molecular Cell. 2: 353-9. PMID 9774973 DOI: 10.1016/S1097-2765(00)80279-8  0.68
1997 Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 91: 961-71. PMID 9428519 DOI: 10.1016/S0092-8674(00)80487-0  0.68
1997 Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (New York, N.Y.). 278: 1957-60. PMID 9395400 DOI: 10.1126/Science.278.5345.1957  0.8
1997 Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR. Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart Journal of Biological Chemistry. 272: 23696-23702. PMID 9295312 DOI: 10.1074/Jbc.272.38.23696  0.8
1996 Burke PA, Luo M, Zhu J, Yaffe MB, Forse RA. Injury induces rapid changes in hepatocyte nuclear factor-1:DNA binding Surgery. 120: 374-381. PMID 8751607 DOI: 10.1016/S0039-6060(96)80312-6  0.8
1993 Yaffe MB, Murthy S, Eckert RL. Evidence that involucrin is a covalently linked constituent of highly purified cultured keratinocyte cornified envelopes. The Journal of Investigative Dermatology. 100: 3-9. PMID 8423390 DOI: 10.1111/1523-1747.Ep12349857  0.8
1993 Sternlicht H, Farr GW, Sternlicht ML, Driscoll JK, Willison K, Yaffe MB. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Proceedings of the National Academy of Sciences of the United States of America. 90: 9422-6. PMID 8105476 DOI: 10.1073/Pnas.90.20.9422  0.8
1993 Eckert RL, Yaffe MB, Crish JF, Murthy S, Rorke EA, Welter JF. Involucrin--structure and role in envelope assembly. The Journal of Investigative Dermatology. 100: 613-7. PMID 8098344 DOI: 10.1111/1523-1747.Ep12472288  0.8
1993 Szasz J, Yaffe MB, Sternlicht H. Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region. Biophysical Journal. 64: 792-802. PMID 8097117 DOI: 10.1016/S0006-3495(93)81440-1  0.8
1992 Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature. 358: 245-8. PMID 1630491 DOI: 10.1038/358245A0  0.8
1990 Farr GW, Yaffe MB, Sternlicht H. Alpha-tubulin influences nucleotide binding to beta-tubulin: an assay using picomoles of unpurified protein. Proceedings of the National Academy of Sciences of the United States of America. 87: 5041-5. PMID 2367522 DOI: 10.1073/Pnas.87.13.5041  0.8
1989 Yaffe MB, Farr GW, Sternlicht H. Kinetics of beta-tubulin exchange following translation. Evidence for a slow conformational change in beta-tubulin necessary for incorporation into heterodimers. The Journal of Biological Chemistry. 264: 19045-51. PMID 2808409  0.8
1988 Yaffe MB, Farr GW, Sternlicht H. Translation of beta-tubulin mRNA in vitro generates multiple molecular forms. The Journal of Biological Chemistry. 263: 16023-31. PMID 3182779  0.8
1988 Yaffe MB, Levison BS, Szasz J, Sternlicht H. Expression of a human alpha-tubulin: properties of the isolated subunit. Biochemistry. 27: 1869-80. PMID 2897863 DOI: 10.1021/Bi00406A012  0.8
1987 Sternlicht H, Yaffe MB, Farr GW. A model of the nucleotide-binding site in tubulin. Febs Letters. 214: 226-35. PMID 3106086 DOI: 10.1016/0014-5793(87)80061-3  0.8
1986 Szasz J, Yaffe MB, Elzinga M, Blank GS, Sternlicht H. Microtubule assembly is dependent on a cluster of basic residues in alpha-tubulin. Biochemistry. 25: 4572-82. PMID 3768299 DOI: 10.1021/Bi00364A018  0.8
1986 Blank GS, Yaffe MB, Szasz J, George E, Rosenberry TL, Sternlicht H. The role of Lys 394 in microtubule assembly. Annals of the New York Academy of Sciences. 466: 467-81. PMID 3089112 DOI: 10.1111/J.1749-6632.1986.Tb38425.X  0.8
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