Martin E. Tanner, Ph.D. - Publications

Affiliations: 
Chemistry University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Studies on novel enzyme mechanisms; epimerases and racemases; sugar nucleotide-modifying enzymes; isotope effects; inhibitor design; site-directed mutagenesis
Website:
http://www.chem.ubc.ca/our-people/profiles/martin-tanner

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Liu Y, Frirdich E, Taylor JA, Chan AC, Blair KM, Vermeulen J, Ha R, Murphy ME, Salama NR, Gaynor EC, Tanner ME. A Bacterial Cell Shape-Determining Inhibitor. Acs Chemical Biology. PMID 26735022 DOI: 10.1021/acschembio.5b01039  1
2015 Chan AC, Blair KM, Liu Y, Frirdich E, Gaynor EC, Tanner ME, Salama NR, Murphy ME. Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4. The Journal of Biological Chemistry. 290: 3622-38. PMID 25505267 DOI: 10.1074/jbc.M114.624734  1
2015 Tanner ME. Mechanistic studies on the indole prenyltransferases Natural Product Reports. 32: 88-101. PMID 25270661 DOI: 10.1039/c4np00099d  1
2015 Tanner ME. Increasing the Diversity of Known Pictet-Spenglerases Chemistry and Biology. 22: 806-807. DOI: 10.1016/j.chembiol.2015.07.003  1
2014 Awakawa T, Zhang L, Wakimoto T, Hoshino S, Mori T, Ito T, Ishikawa J, Tanner ME, Abe I. A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis. Journal of the American Chemical Society. 136: 9910-3. PMID 24992358 DOI: 10.1021/ja505224r  1
2013 Hadi T, Hazra S, Tanner ME, Blanchard JS. Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor. Biochemistry. 52: 9358-66. PMID 24251551 DOI: 10.1021/bi4010446  1
2013 Mahmoodi N, Tanner ME. Potential rearrangements in the reaction catalyzed by the indole prenyltransferase FtmPT1 Chembiochem. 14: 2029-2037. PMID 24014462 DOI: 10.1002/cbic.201300385  1
2013 Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM. Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes. Biochemistry. 52: 6525-36. PMID 23972005 DOI: 10.1021/bi400750a  1
2013 Liu Y, Garnham CP, Roll-Mecak A, Tanner ME. Phosphinic acid-based inhibitors of tubulin polyglutamylases Bioorganic and Medicinal Chemistry Letters. 23: 4408-4412. PMID 23777780 DOI: 10.1016/j.bmcl.2013.05.069  1
2013 Miyafusa T, Caaveiro JMM, Tanaka Y, Tanner ME, Tsumoto K. Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus. Bioscience Reports. 33. PMID 23611437 DOI: 10.1042/BSR20130017  1
2013 Mahmoodi N, Qian Q, Luk LYP, Tanner ME. Rearrangements in the mechanisms of the indole alkaloid prenyltransferases Pure and Applied Chemistry. 85: 1935-1948. DOI: 10.1351/PAC-CON-13-02-02  1
2012 Qian Q, Schultz AW, Moore BS, Tanner ME. Mechanistic studies on CymD: a tryptophan reverse N-prenyltransferase. Biochemistry. 51: 7733-9. PMID 22935004 DOI: 10.1021/bi3009054  1
2012 Otto NJ, Green DE, Masuko S, Mayer A, Tanner ME, Linhardt RJ, DeAngelis PL. Structure/function analysis of Pasteurella multocida heparosan synthases: Toward defining enzyme specificity and engineering novel catalysts Journal of Biological Chemistry. 287: 7203-7212. PMID 22235128 DOI: 10.1074/jbc.M111.311704  1
2011 Luk LYP, Qian Q, Tanner ME. A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase? Journal of the American Chemical Society. 133: 12342-12345. PMID 21766851 DOI: 10.1021/ja2034969  1
2011 Li X, Apel D, Gaynor EC, Tanner ME. 5′-Methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni Journal of Biological Chemistry. 286: 19392-19398. PMID 21489995 DOI: 10.1074/jbc.M111.229781  1
2011 Mayer A, Gloster TM, Chou WK, Vocadlo DJ, Tanner ME. 6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate. Bioorganic & Medicinal Chemistry Letters. 21: 1199-201. PMID 21273069 DOI: 10.1016/j.bmcl.2010.12.090  1
2011 Hadi T, Pfeffer JM, Clarke AJ, Tanner ME. Water-soluble substrates of the peptidoglycan-modifying enzyme O-acetylpeptidoglycan esterase (Ape1) from Neisseria gonorrheae Journal of Organic Chemistry. 76: 1118-1125. PMID 21244065 DOI: 10.1021/jo102329c  1
2010 Kowatz T, Morrison JP, Tanner ME, Naismith JH. The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-β-D-mannose suggests a one base mechanism Protein Science. 19: 1337-1343. PMID 20506248 DOI: 10.1002/pro.410  1
2010 Li X, Tanner ME. An efficient synthesis of futalosine Tetrahedron Letters. 51: 6463-6465. DOI: 10.1016/j.tetlet.2010.10.010  1
2009 Luk LYP, Tanner ME. Mechanism of dimethylallyltryptophan synthase: Evidence for a dimethylallyl cation intermediate in an aromatic prenyltransferase reaction Journal of the American Chemical Society. 131: 13932-13933. PMID 19743851 DOI: 10.1021/ja906485u  1
2009 Liu F, Lee HJ, Strynadka NC, Tanner ME. Inhibition of Neisseria meningitidis sialic acid synthase by a tetrahedral intermediate analogue. Biochemistry. 48: 9194-201. PMID 19719325 DOI: 10.1021/bi9012758  1
2009 Liu F, Aubry AJ, Schoenhofen IC, Logan SM, Tanner ME. The engineering of bacteria. Bearing azido-pseudaminic acid-modified flagella Chembiochem. 10: 1317-1320. DOI: 10.1002/cbic.200900018  1
2008 Lau STB, Tanner ME. Mechanism and active site residues of GDP-fucose synthase Journal of the American Chemical Society. 130: 17593-17602. PMID 19053199 DOI: 10.1021/ja807799k  1
2008 Morrison JP, Schoenhofen IC, Tanner ME. Mechanistic studies on PseB of pseudaminic acid biosynthesis: A UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase Bioorganic Chemistry. 36: 312-320. PMID 18845311 DOI: 10.1016/j.bioorg.2008.08.004  1
2008 Hadi T, Dahl U, Mayer C, Tanner ME. Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): An etherase involved in peptidoglycan recycling Biochemistry. 47: 11547-11558. PMID 18837509 DOI: 10.1021/bi8014532  1
2008 Tanner ME. Transient oxidation as a mechanistic strategy in enzymatic catalysis Current Opinion in Chemical Biology. 12: 532-538. PMID 18625333 DOI: 10.1016/j.cbpa.2008.06.016  1
2008 Glaze PA, Watson DC, Young NM, Tanner ME. Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila Biochemistry. 47: 3272-3282. PMID 18275154 DOI: 10.1021/bi702364s  1
2007 Luk LYP, Bunn S, Liscombe DK, Facchini PJ, Tanner ME. Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: An enzymatic Pictet-Spengler reaction Biochemistry. 46: 10153-10161. PMID 17696451 DOI: 10.1021/bi700752n  1
2007 Mayer A, Tanner ME. Intermediate release by ADP-L-glycero-D-manno-heptose 6-epimerase Biochemistry. 46: 6149-6155. PMID 17455913 DOI: 10.1021/bi700332h  1
2007 Morrison JP, Tanner ME. A two-base mechanism for Escherichia coli ADP-L-glycero-D-manno-heptose 6-epimerase Biochemistry. 46: 3916-3924. PMID 17316025 DOI: 10.1021/bi602641m  1
2006 Liu F, Tanner ME. PseG of pseudaminic acid biosynthesis: A UDP-sugar hydrolase as a masked glycosyltransferase Journal of Biological Chemistry. 281: 20902-20909. PMID 16728396 DOI: 10.1074/jbc.M602972200  1
2005 Chou WK, Dick S, Wakarchuk WW, Tanner ME. Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase. The Journal of Biological Chemistry. 280: 35922-8. PMID 16120604 DOI: 10.1074/jbc.M507483200  1
2005 Read JA, Ahmed RA, Tanner ME. Efficient chemoenzymatic synthesis of ADP-D-glycero-β-D-manno-heptose and a mechanistic study of ADP-L-glycero-D-manno-heptose 6-epimerase Organic Letters. 7: 2457-2460. PMID 15932222 DOI: 10.1021/ol050774q  1
2005 Tanner ME. The enzymes of sialic acid biosynthesis Bioorganic Chemistry. 33: 216-228. PMID 15888312 DOI: 10.1016/j.bioorg.2005.01.005  1
2005 Morrison JP, Read JA, Coleman WG, Tanner ME. Dismutase activity of ADP-L-glycero-D-manno-heptose 6-epimerase: Evidence for a direct oxidation/reduction mechanism Biochemistry. 44: 5907-5915. PMID 15823050 DOI: 10.1021/bi050106c  1
2005 Gunawan J, Simard D, Gilbert M, Lovering AL, Wakarchuk WW, Tanner ME, Strynadka NC. Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol. The Journal of Biological Chemistry. 280: 3555-63. PMID 15516336 DOI: 10.1074/jbc.M411942200  1
2004 Murkin AS, Chou WK, Wakarchuk WW, Tanner ME. Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase Biochemistry. 43: 14290-14298. PMID 15518580 DOI: 10.1021/bi048606d  1
2004 Read JA, Ahmed RA, Morrison JP, Coleman WG, Tanner ME. The mechanism of the reaction catalyzed by ADP-β-L-glycero-D-manno- heptose 6-epimerase Journal of the American Chemical Society. 126: 8878-8879. PMID 15264802 DOI: 10.1021/ja0485659  1
2004 Samuel J, Tanner ME. Active site mutants of the "non-hydrolyzing" UDP-N- acetylglucosamine 2-epimerase from Escherichia coli Biochimica Et Biophysica Acta - Proteins and Proteomics. 1700: 85-91. PMID 15210128 DOI: 10.1016/j.bbapap.2004.03.017  1
2004 Vann WF, Daines DA, Murkin AS, Tanner ME, Chaffin DO, Rubens CE, Vionnet J, Silver RP. The NeuC Protein of Escherichia coli K1 is a UDP N-Acetylglucosamine 2-Epimerase Journal of Bacteriology. 186: 706-712. PMID 14729696 DOI: 10.1128/JB.186.3.706-712.2004  1
2004 Ge X, Penney LC, Van De Rijn I, Tanner ME. Active site residues and mechanism of UDP-glucose dehydrogenase European Journal of Biochemistry. 271: 14-22. PMID 14686915 DOI: 10.1046/j.1432-1033.2003.03876.x  1
2003 Chou WK, Hinderlich S, Reutter W, Tanner ME. Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-N-acetylglucosamine 2-epimerase. Journal of the American Chemical Society. 125: 2455-61. PMID 12603133 DOI: 10.1021/ja021309g  1
2002 Murkin AS, Tanner ME. Dehydroalanine-based inhibition of a peptide epimerase from spider venom. The Journal of Organic Chemistry. 67: 8389-94. PMID 12444615  0.88
2002 Samuel J, Tanner ME. Mechanistic aspects of enzymatic carbohydrate epimerization Natural Product Reports. 19: 261-277. PMID 12137277 DOI: 10.1039/b100492l  1
2002 Murkin AS, Tanner ME. Dehydroalanine-based inhibition of a peptide epimerase from spider venom Journal of Organic Chemistry. 67: 8389-8394. DOI: 10.1021/jo0204653  1
2002 Tanner ME. Understanding nature's strategies for enzyme-catalyzed racemization and epimerization Accounts of Chemical Research. 35: 237-246. DOI: 10.1021/ar000056y  1
2001 Samuel J, Luo Y, Morgan PM, Strynadka NC, Tanner ME. Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a comparison with L-fuculose-1-phosphate aldolase. Biochemistry. 40: 14772-80. PMID 11732896 DOI: 10.1021/bi011252v  1
2001 Luo Y, Samuel J, Mosimann SC, Lee JE, Tanner ME, Strynadka NC. The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization. Biochemistry. 40: 14763-71. PMID 11732895 DOI: 10.1021/bi0112513  1
2001 Glavas S, Tanner ME. Active site residues of glutamate racemase Biochemistry. 40: 6199-6204. PMID 11371180 DOI: 10.1021/bi002703z  1
2001 Tanner ME. Sugar nucleotide-modifying enzymes Current Organic Chemistry. 5: 169-192. DOI: 10.2174/1385272013375643  1
2000 Campbell RE, Mosimann SC, Tanner ME, Strynadka NC. The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. Biochemistry. 39: 14993-5001. PMID 11106477 DOI: 10.1021/bi001627x  1
2000 Campbell RE, Mosimann SC, Van De Rijn I, Tanner ME, Strynadka NCJ. The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation Biochemistry. 39: 7012-7023. PMID 10841783 DOI: 10.1021/bi000181h  1
1999 Glavas S, Tanner ME. Catalytic acid/base residues of glutamate racemase Biochemistry. 38: 4106-4113. PMID 10194325 DOI: 10.1021/bi982663n  1
1999 Campbell RE, Tanner ME. UDP-glucose analogues as inhibitors and mechanistic probes of UDP- glucose dehydrogenase Journal of Organic Chemistry. 64: 9487-9492. DOI: 10.1021/jo991092h  1
1999 Galpin JD, Ellis BE, Tanner ME. The inactivation of histidine ammonia-lyase by L-cysteine and oxygen: Modification of the electrophilic center [7] Journal of the American Chemical Society. 121: 10840-10841. DOI: 10.1021/ja992729h  1
1998 Sala RF, MacKinnon SL, Palcic MM, Tanner ME. UDP-N-trifluoroacetylglucosamine as an alternative substrate in N- acetylglucosaminyltransferase reactions Carbohydrate Research. 306: 127-136. PMID 9691444 DOI: 10.1016/S0008-6215(97)10033-7  1
1998 Johnson AE, Tanner ME. Epimerization via carbon-carbon bond cleavage. L-ribulose-5-phosphate 4- epimerase as a masked class II aldolase Biochemistry. 37: 5746-5754. PMID 9548961 DOI: 10.1021/bi972984j  1
1998 Zeng B, Wong KK, Pompliano DL, Reddy S, Tanner ME. A phosphinate inhibitor of the meso-diaminopimelic acid-adding enzyme (MurE) of peptidoglycan biosynthesis Journal of Organic Chemistry. 63: 10081-10086. DOI: 10.1021/jo981895p  1
1998 Ge X, Campbell RE, Van de Rijn I, Tanner ME. Covalent adduct formation with a mutated enzyme: Evidence for a thioester intermediate in the reaction catalyzed by UDP-glucose dehydrogenase Journal of the American Chemical Society. 120: 6613-6614. DOI: 10.1021/ja9805977  1
1997 Campbell RE, Sala RF, Van de Rijn I, Tanner ME. Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci. Irreversible inhibition by UDP-chloroacetol Journal of Biological Chemistry. 272: 3416-3422. PMID 9013585 DOI: 10.1074/jbc.272.6.3416  1
1997 Morgan PM, Sala RF, Tanner ME. Eliminations in the reactions catalyzed by UDP-N-acetylglucosamine 2-epimerase Journal of the American Chemical Society. 119: 10269-10277. DOI: 10.1021/ja971718q  1
1997 Glavas S, Tanner ME. The inhibition of glutamate racemase by D-N hydroxyglutamate Bioorganic and Medicinal Chemistry Letters. 7: 2265-2270. DOI: 10.1016/S0960-894X(97)00413-7  1
1997 Campbell RE, Tanner ME. Uridine diphospho-α-D-gluco-hexodialdose: Synthesis and kinetic competence in the reaction catalyzed by UDP-glucose dehydrogenase Angewandte Chemie - International Edition in English. 36: 1520-1522.  1
1996 Vaganay S, Tanner ME, Van Heijenoort J, Blanot D. Study of the reaction mechanism of the D-glutamic acid-adding enzyme from Escherichia coli Microbial Drug Resistance. 2: 51-54. PMID 9158722  1
1996 Tanner ME, Vaganay S, Van Heijenoort J, Blanot D. Phosphinate inhibitors of the D-glutamic acid-adding enzyme of peptidoglycan biosynthesis Journal of Organic Chemistry. 61: 1756-1760. DOI: 10.1021/jo951780a  1
1996 Sala RF, Morgan PM, Tanner ME. Enzymatic formation and release of a stable glycal intermediate: The mechanism of the reaction catalyzed by UDP-N-acetylglucosamine 2-epimerase Journal of the American Chemical Society. 118: 3033-3034. DOI: 10.1021/ja960266z  1
1994 Tanner ME, Miao S. The synthesis and stability of aziridino-glutamate, an irreversible inhibitor of glutamate racemase Tetrahedron Letters. 35: 4073-4076. DOI: 10.1016/S0040-4039(00)73115-7  1
1993 Tanner ME, Gallo KA, Knowles JR. Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase. Biochemistry. 32: 3998-4006. PMID 8097110  1
1993 Tanner ME, Gallo KA, Knowles JR. Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase. Biochemistry. 32: 3998-4006. PMID 8097110  1
1992 Tanner ME, Knobler CB, Cram DJ. Rigidly hollow hosts that encapsulate small molecules Journal of Organic Chemistry. 57: 40-46.  1
1992 Tanner ME, Knobler CB, Cram DJ. Rigidly hollow hosts that encapsulate small molecules Journal of Organic Chemistry. 57: 40-46.  1
1991 Cram DJ, Tanner ME, Keipert SJ, Knobler CB. Two chiral [1.1.1]orthocyclophane units bridged by three biacetylene units as a host which binds medium-sized organic guests Journal of the American Chemical Society. 113: 8909-8916.  1
1991 Cram DJ, Tanner ME, Keipert SJ, Knobler CB. Two chiral [1.1.1]orthocyclophane units bridged by three biacetylene units as a host which binds medium-sized organic guests Journal of the American Chemical Society. 113: 8909-8916.  1
1991 Cram DJ, Tanner ME, Knobler CB. Guest release and capture by hemicarcerands introduces the phenomonen of constructive binding Journal of the American Chemical Society. 113: 7717-7727.  1
1991 Cram DJ, Tanner ME, Knobler CB. Guest release and capture by hemicarcerands introduces the phenomonen of constructive binding Journal of the American Chemical Society. 113: 7717-7727.  1
1991 Cram DJ, Tanner ME, Thomas R. The taming of cyclobutadiene Angewandte Chemie (International Edition in English). 30: 1024-1027.  1
1990 Tanner ME, Knobler CB, Cram DJ. Hemicarcerands permit entrance to and egress from their inside phases with high structural recognition and activation free energies Journal of the American Chemical Society. 112: 1659-1660.  1
1990 Tanner ME, Knobler CB, Cram DJ. Hemicarcerands permit entrance to and egress from their inside phases with high structural recognition and activation free energies Journal of the American Chemical Society. 112: 1659-1660.  1
1985 Casal HL, Tanner M, Werstiuk NH, Scaiano JC. Fluorenone oxide: Transient spectroscopy and kinetics of its formation and reactions Journal of the American Chemical Society. 107: 4616-4620.  1
1985 Scaiano JC, Tanner M, Weir D. Exploratory study of the intermolecular reactivity of excited diphenylmethyl radicals Journal of the American Chemical Society. 107: 4396-4403.  1
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