David G Fernig - Publications

Affiliations: 
University of Liverpool, LIVERPOOL, UK. 
Area:
growth factors, glycosaminoglycans, receptor tyrosine kinases, signaling, nanoparticles, extracellular matrix

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sun C, Liu M, Sun P, Yang M, Yates EA, Guo Z, Fernig DG. Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation. Febs Open Bio. PMID 31271519 DOI: 10.1002/2211-5463.12696  0.377
2018 Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Lu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, et al. New tools for carbohydrate sulphation analysis: Heparan Sulphate 2- -sulphotransferase (HS2ST) is a target for small molecule protein kinase inhibitors. The Biochemical Journal. PMID 29934491 DOI: 10.1042/Bcj20180265  0.318
2018 Yang H, Tian H, Cheng J, Zheng J, Wang D, Sun C, Fernig D, Chen T, Gong W, Wang S, Li X, Jiang C. Highly efficient production of functional recombinant human fibroblast growth factor 22 in E. coli and its protective effects on HO-lesioned L02 cells. Protein Expression and Purification. PMID 29627393 DOI: 10.1016/J.Pep.2018.04.002  0.336
2017 Wang S, Lin H, Zhao T, Huang S, Fernig DG, Xu N, Wu F, Zhou M, Jiang C, Tian H. Expression and purification of an FGF9 fusion protein in E. coli, and the effects of the FGF9 subfamily on human hepatocellular carcinoma cell proliferation and migration. Applied Microbiology and Biotechnology. PMID 28921304 DOI: 10.1007/S00253-017-8468-1  0.389
2017 Zheng J, Wang S, Yang H, Chen Z, Huang S, Zhao T, Pan X, Fernig DG, Jiang C, Li X, Tian H. Large-Scale Expression, Purification of Bioactive Recombinant Human FGF6 in E. coli and the Mechanisms of Its Myocardial Protection International Journal of Peptide Research and Therapeutics. 24: 105-115. DOI: 10.1007/S10989-017-9592-6  0.384
2016 Paramelle D, Peng T, Free P, Fernig DG, Lim S, Tomczak N. Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding. Plos One. 11: e0162848. PMID 27622533 DOI: 10.1371/Journal.Pone.0162848  0.317
2016 Li Y, Sun C, Yates EA, Jiang C, Wilkinson MC, Fernig DG. Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Open Biology. 6. PMID 27030175 DOI: 10.1098/Rsob.150275  0.378
2016 Sun C, Marcello M, Li Y, Mason D, Lévy R, Fernig DG. Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix. Open Biology. 6. PMID 27009190 DOI: 10.1098/Rsob.150277  0.372
2016 Lackey B, Nunes QM, Higham SM, Fernig DG, Valappil SP. In silico analyses of heparin binding proteins expression in human periodontal tissues. Bmc Research Notes. 9: 53. PMID 26821679 DOI: 10.1186/S13104-016-1857-1  0.311
2016 Nunes QM, Li Y, Sun C, Kinnunen TK, Fernig DG. Fibroblast growth factors as tissue repair and regeneration therapeutics. Peerj. 4: e1535. PMID 26793421 DOI: 10.7717/Peerj.1535  0.345
2015 Tian H, Zhao Y, Chen N, Wu M, Gong W, Zheng J, Fernig DG, Jungbauer A, Wang D, Li X, Jiang C. High production in E. coli of biologically active recombinant human fibroblast growth factor 20 and its neuroprotective effects. Applied Microbiology and Biotechnology. PMID 26603761 DOI: 10.1007/S00253-015-7168-Y  0.374
2015 Lee J, Wee S, Gunaratne J, Chua RJ, Smith RA, Ling L, Fernig DG, Swaminathan K, Nurcombe V, Cool SM. Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signalling. Glycobiology. PMID 26306634 DOI: 10.1093/Glycob/Cwv064  0.318
2015 Migliorini E, Thakar D, Kühnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP. Cytokines and growth factors cross-link heparan sulfate. Open Biology. 5. PMID 26269427 DOI: 10.1098/Rsob.150046  0.401
2015 Sun C, Li Y, Taylor SE, Mao X, Wilkinson MC, Fernig DG. HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors. Peerj. 3: e1060. PMID 26137434 DOI: 10.7717/Peerj.1060  0.356
2015 Paramelle D, Nieves D, Brun B, Kraut RS, Fernig DG. Targeting Cell Membrane Lipid Rafts by Stoichiometric Functionalization of Gold Nanoparticles With a Sphingolipid-Binding Domain Peptide. Advanced Healthcare Materials. 4: 911-7. PMID 25650337 DOI: 10.1002/Adhm.201400730  0.312
2014 Mournetas V, Nunes QM, Murray PA, Sanderson CM, Fernig DG. Network based meta-analysis prediction of microenvironmental relays involved in stemness of human embryonic stem cells. Peerj. 2: e618. PMID 25374775 DOI: 10.7717/Peerj.618  0.341
2014 Dos Santos C, Blanc C, Elahouel R, Prescott M, Carpentier G, Ori A, Courty J, Hamma-Kourbali Y, Fernig DG, Delbé J. Proliferation and migration activities of fibroblast growth factor-2 in endothelial cells are modulated by its direct interaction with heparin affin regulatory peptide. Biochimie. 107: 350-7. PMID 25315978 DOI: 10.1016/J.Biochi.2014.10.002  0.431
2014 Uniewicz KA, Ori A, Ahmed YA, Yates EA, Fernig DG. Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars. Peerj. 2: e461. PMID 25024924 DOI: 10.7717/Peerj.461  0.353
2013 Xu R, Rudd TR, Hughes AJ, Siligardi G, Fernig DG, Yates EA. Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network. The Febs Journal. 280: 2260-70. PMID 23441759 DOI: 10.1111/Febs.12201  0.315
2012 Xu R, Ori A, Rudd TR, Uniewicz KA, Ahmed YA, Guimond SE, Skidmore MA, Siligardi G, Yates EA, Fernig DG. Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity. The Journal of Biological Chemistry. 287: 40061-73. PMID 23019343 DOI: 10.1074/Jbc.M112.398826  0.373
2012 Duchesne L, Octeau V, Bearon RN, Beckett A, Prior IA, Lounis B, Fernig DG. Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate. Plos Biology. 10: e1001361. PMID 22815649 DOI: 10.1371/Journal.Pbio.1001361  0.365
2012 Puvirajesinghe TM, Ahmed YA, Powell AK, Fernig DG, Guimond SE, Turnbull JE. Array-based functional screening of heparin glycans. Chemistry & Biology. 19: 553-8. PMID 22633407 DOI: 10.1016/J.Chembiol.2012.03.011  0.374
2012 Du M, Wang G, Ismail TM, Gross S, Fernig DG, Barraclough R, Rudland PS. S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration. The Journal of Biological Chemistry. 287: 15330-44. PMID 22399300 DOI: 10.1074/Jbc.M112.349787  0.555
2012 Uniewicz KA, Ori A, Rudd TR, Guerrini M, Wilkinson MC, Fernig DG, Yates EA. Following protein-glycosaminoglycan polysaccharide interactions with differential scanning fluorimetry. Methods in Molecular Biology (Clifton, N.J.). 836: 171-82. PMID 22252635 DOI: 10.1007/978-1-61779-498-8_12  0.329
2011 Ori A, Wilkinson MC, Fernig DG. A systems biology approach for the investigation of the heparin/heparan sulfate interactome. The Journal of Biological Chemistry. 286: 19892-904. PMID 21454685 DOI: 10.1074/Jbc.M111.228114  0.352
2011 Polanska UM, Edwards E, Fernig DG, Kinnunen TK. The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans. The Journal of Biological Chemistry. 286: 5657-66. PMID 21177529 DOI: 10.1074/Jbc.M110.173039  0.313
2011 Uniewicz KA, Cross MJ, Fernig DG. Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis. The Journal of Biological Chemistry. 286: 12-23. PMID 20956519 DOI: 10.1074/Jbc.M110.190801  0.331
2010 Rudd TR, Uniewicz KA, Ori A, Guimond SE, Skidmore MA, Gaudesi D, Xu R, Turnbull JE, Guerrini M, Torri G, Siligardi G, Wilkinson MC, Fernig DG, Yates EA. Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Organic & Biomolecular Chemistry. 8: 5390-7. PMID 20865198 DOI: 10.1039/C0Ob00246A  0.367
2010 Zhu H, Duchesne L, Rudland PS, Fernig DG. The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor. Cell Communication and Signaling : Ccs. 8: 14. PMID 20576134 DOI: 10.1186/1478-811X-8-14  0.558
2010 Uniewicz KA, Ori A, Xu R, Ahmed Y, Wilkinson MC, Fernig DG, Yates EA. Differential scanning fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a screening test for binding specificity. Analytical Chemistry. 82: 3796-802. PMID 20353159 DOI: 10.1021/Ac100188X  0.369
2010 Thompson SM, Jesudason EC, Turnbull JE, Fernig DG. Heparan sulfate in lung morphogenesis: The elephant in the room. Birth Defects Research. Part C, Embryo Today : Reviews. 90: 32-44. PMID 20301217 DOI: 10.1002/Bdrc.20169  0.302
2010 Ismail TM, Zhang S, Fernig DG, Gross S, Martin-Fernandez ML, See V, Tozawa K, Tynan CJ, Wang G, Wilkinson MC, Rudland PS, Barraclough R. Self-association of calcium-binding protein S100A4 and metastasis. The Journal of Biological Chemistry. 285: 914-22. PMID 19917604 DOI: 10.1074/Jbc.M109.010892  0.566
2009 Thompson SM, Fernig DG, Jesudason EC, Losty PD, van de Westerlo EM, van Kuppevelt TH, Turnbull JE. Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities. The Journal of Biological Chemistry. 284: 35621-31. PMID 19837661 DOI: 10.1074/Jbc.M109.009712  0.332
2009 Polanska UM, Duchesne L, Harries JC, Fernig DG, Kinnunen TK. N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo. The Journal of Biological Chemistry. 284: 33030-9. PMID 19801543 DOI: 10.1074/Jbc.M109.058925  0.332
2009 Daghestani HN, Fernig DG, Day BW. Evaluation of biosensor surfaces for the detection of microtubule perturbation. Biosensors & Bioelectronics. 25: 136-41. PMID 19595587 DOI: 10.1016/J.Bios.2009.06.014  0.307
2009 Ori A, Free P, Courty J, Wilkinson MC, Fernig DG. Identification of heparin-binding sites in proteins by selective labeling. Molecular & Cellular Proteomics : McP. 8: 2256-65. PMID 19567366 DOI: 10.1074/Mcp.M900031-Mcp200  0.349
2009 Guimond SE, Rudd TR, Skidmore MA, Ori A, Gaudesi D, Cosentino C, Guerrini M, Edge R, Collison D, McInnes E, Torri G, Turnbull JE, Fernig DG, Yates EA. Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution. Biochemistry. 48: 4772-9. PMID 19400583 DOI: 10.1021/Bi802318Z  0.333
2009 Popplewell JF, Swann MJ, Ahmed Y, Turnbull JE, Fernig DG. Fabrication of carbohydrate surfaces by using nonderivatised oligosaccharides, and their application to measuring the assembly of sugar-protein complexes Chembiochem. 10: 1218-1226. PMID 19360804 DOI: 10.1002/Cbic.200800696  0.331
2009 Polanska UM, Fernig DG, Kinnunen T. Extracellular interactome of the FGF receptor-ligand system: complexities and the relative simplicity of the worm. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 277-93. PMID 18985724 DOI: 10.1002/Dvdy.21757  0.364
2008 Kurisetty VV, Johnston PG, Johnston N, Erwin P, Crowe P, Fernig DG, Campbell FC, Anderson IP, Rudland PS, El-Tanani MK. RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin. Oncogene. 27: 7139-49. PMID 18794800 DOI: 10.1038/Onc.2008.325  0.573
2008 Ismail TM, Fernig DG, Rudland PS, Terry CJ, Wang G, Barraclough R. The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis. Carcinogenesis. 29: 2259-66. PMID 18784356 DOI: 10.1093/Carcin/Bgn217  0.545
2008 Skidmore MA, Guimond SE, Rudd TR, Fernig DG, Turnbull JE, Yates EA. The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation. Connective Tissue Research. 49: 140-4. PMID 18661329 DOI: 10.1080/03008200802148595  0.315
2008 Uniewicz KA, Fernig DG. Neuropilins: a versatile partner of extracellular molecules that regulate development and disease. Frontiers in Bioscience. 13: 4339. PMID 18508514 DOI: 10.2741/3008  0.37
2008 Ori A, Wilkinson MC, Fernig DG. The heparanome and regulation of cell function: structures, functions and challenges. Frontiers in Bioscience. 13: 4309-4338. PMID 18508513 DOI: 10.2741/3007  0.336
2008 Catlow KR, Deakin JA, Wei Z, Delehedde M, Fernig DG, Gherardi E, Gallagher JT, Pavão MS, Lyon M. Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density. The Journal of Biological Chemistry. 283: 5235-48. PMID 18156180 DOI: 10.1074/Jbc.M706589200  0.357
2008 Hamma-Kourbali Y, Bernard-Pierrot I, Heroult M, Dalle S, Caruelle D, Milhiet PE, Fernig DG, Delbé J, Courty J. Inhibition of the mitogenic, angiogenic and tumorigenic activities of pleiotrophin by a synthetic peptide corresponding to its C-thrombospondin repeat-I domain. Journal of Cellular Physiology. 214: 250-9. PMID 17607711 DOI: 10.1002/Jcp.21191  0.376
2007 Bermek O, Diamantopoulou Z, Polykratis A, Dos Santos C, Hamma-Kourbali Y, Burlina F, Delbé J, Chassaing G, Fernig DG, Katsoris P, Courty J. A basic peptide derived from the HARP C-terminus inhibits anchorage-independent growth of DU145 prostate cancer cells. Experimental Cell Research. 313: 4041-50. PMID 17727841 DOI: 10.1016/J.Yexcr.2007.07.032  0.368
2007 Vanpouille C, Deligny A, Delehedde M, Denys A, Melchior A, Liénard X, Lyon M, Mazurier J, Fernig DG, Allain F. The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue. The Journal of Biological Chemistry. 282: 24416-29. PMID 17588944 DOI: 10.1074/Jbc.M701835200  0.347
2007 Rudd TR, Guimond SE, Skidmore MA, Duchesne L, Guerrini M, Torri G, Cosentino C, Brown A, Clarke DT, Turnbull JE, Fernig DG, Yates EA. Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. Glycobiology. 17: 983-93. PMID 17580314 DOI: 10.1093/Glycob/Cwm062  0.315
2007 Schofield AL, Rudd TR, Martin DS, Fernig DG, Edwards C. Real-time monitoring of the development and stability of biofilms of Streptococcus mutans using the quartz crystal microbalance with dissipation monitoring. Biosensors & Bioelectronics. 23: 407-13. PMID 17580113 DOI: 10.1016/J.Bios.2007.05.001  0.307
2007 Thompson SM, Connell MG, Fernig DG, Ten Dam GB, van Kuppevelt TH, Turnbull JE, Jesudason EC, Losty PD. Novel 'phage display antibodies identify distinct heparan sulfate domains in developing mammalian lung. Pediatric Surgery International. 23: 411-7. PMID 17216534 DOI: 10.1007/S00383-006-1864-8  0.318
2006 Duchesne L, Tissot B, Rudd TR, Dell A, Fernig DG. N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding. The Journal of Biological Chemistry. 281: 27178-89. PMID 16829530 DOI: 10.1074/Jbc.M601248200  0.359
2005 Zhang S, Wang G, Liu D, Bao Z, Fernig DG, Rudland PS, Barraclough R. The C-terminal region of S100A4 is important for its metastasis-inducing properties Oncogene. 24: 4401-4411. PMID 15856021 DOI: 10.1038/Sj.Onc.1208663  0.565
2005 West DC, Rees CG, Duchesne L, Patey SJ, Terry CJ, Turnbull JE, Delehedde M, Heegaard CW, Allain F, Vanpouille C, Ron D, Fernig DG. Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. The Journal of Biological Chemistry. 280: 13457-64. PMID 15695515 DOI: 10.1074/Jbc.M410924200  0.426
2005 Wang G, Zhang S, Fernig DG, Martin-Fernandez M, Rudland PS, Barraclough R. Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes. Oncogene. 24: 1445-54. PMID 15608682 DOI: 10.1038/Sj.Onc.1208291  0.585
2005 Zhang S, Wang G, Fernig DG, Rudland PS, Webb SE, Barraclough R, Martin-Fernandez M. Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. European Biophysics Journal : Ebj. 34: 19-27. PMID 15289939 DOI: 10.1007/S00249-004-0428-X  0.544
2004 Wang G, Zhang S, Fernig DG, Spiller D, Martin-Fernandez M, Zhang H, Ding Y, Rao Z, Rudland PS, Barraclough R. Heterodimeric interaction and interfaces of S100A1 and S100P. The Biochemical Journal. 382: 375-83. PMID 15171681 DOI: 10.1042/Bj20040142  0.529
2004 Powell AK, Yates EA, Fernig DG, Turnbull JE. Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. Glycobiology. 14: 17R-30R. PMID 14718374 DOI: 10.1093/Glycob/Cwh051  0.359
2004 Rudd T, Duchesne L, Fernig DG, Nichols RJ. The analysis of the fibroblast growth factor ligand-receptor complex using a quartz crystal microbalance-dissipation International Journal of Experimental Pathology. 85: A72-A73. DOI: 10.1111/J.0959-9673.2004.390Al.X  0.361
2004 Catlow K, Deakin JA, Delehedde M, Fernig DG, Pavao MS, Gallagher JT, Lyon M. Molecular recognition and modulation of hepatocyte growth factor activity by heparan and dermatan sulfates International Journal of Experimental Pathology. 85: A58-A58. DOI: 10.1111/J.0959-9673.2004.0390P.X  0.396
2003 Catlow K, Deakin JA, Delehedde M, Fernig DG, Gallagher JT, Pavão MS, Lyon M. Hepatocyte growth factor/scatter factor and its interaction with heparan sulphate and dermatan sulphate. Biochemical Society Transactions. 31: 352-3. PMID 12653636 DOI: 10.1042/Bst0310352  0.396
2003 Rudd T, Gallagher JT, Ron D, Nichols RJ, Fernig DG. A gravimetric analysis of protein-oligosaccharide interactions. Biochemical Society Transactions. 31: 349-51. PMID 12653635 DOI: 10.1042/Bst0310349  0.367
2003 Zhang H, Wang G, Ding Y, Wang Z, Barraclough R, Rudland PS, Fernig DG, Rao Z. The crystal structure at 2A resolution of the Ca2+ -binding protein S100P. Journal of Molecular Biology. 325: 785-94. PMID 12507480 DOI: 10.1016/S0022-2836(02)01278-0  0.552
2003 Chen H, Fernig DG, Rudland PS, Sparks A, Wilkinson MC, Barraclough R. Erratum to “Binding to Intracellular Targets of the Metastasis-Inducing Protein, S100A4 (p9Ka)” [Biochem. Biophys. Res. Commun. 286 (2001) 1212–1217] Biochemical and Biophysical Research Communications. 308: 408. DOI: 10.1016/S0006-291X(03)01310-X  0.499
2002 Powell AK, Fernig DG, Turnbull JE. Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex. The Journal of Biological Chemistry. 277: 28554-63. PMID 12034712 DOI: 10.1074/Jbc.M111754200  0.386
2002 Delehedde M, Lyon M, Gallagher JT, Rudland PS, Fernig DG. Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts. The Biochemical Journal. 366: 235-44. PMID 12000311 DOI: 10.1042/Bj20011718  0.597
2002 Delehedde M, Lyon M, Vidyasagar R, McDonnell TJ, Fernig DG. Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes. The Journal of Biological Chemistry. 277: 12456-62. PMID 11799124 DOI: 10.1074/Jbc.M111345200  0.394
2002 Ostrovsky O, Berman B, Gallagher J, Mulloy B, Fernig DG, Delehedde M, Ron D. Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes. The Journal of Biological Chemistry. 277: 2444-53. PMID 11714710 DOI: 10.1074/Jbc.M108540200  0.377
2001 Milton JD, Fernig DG, Rhodes JM. Use of a biosensor to determine the binding kinetics of five lectins for Galactosyl-N-acetylgalactosamine. Glycoconjugate Journal. 18: 565-9. PMID 12151718 DOI: 10.1023/A:1019655303395  0.318
2001 Béchard D, Gentina T, Delehedde M, Scherpereel A, Lyon M, Aumercier M, Vazeux R, Richet C, Degand P, Jude B, Janin A, Fernig DG, Tonnel AB, Lassalle P. Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity. The Journal of Biological Chemistry. 276: 48341-9. PMID 11590178 DOI: 10.1074/Jbc.M108395200  0.398
2001 Delehedde M, Lyon M, Sergeant N, Rahmoune H, Fernig DG. Proteoglycans: Pericellular and Cell Surface Multireceptors that Integrate External Stimuli in the Mammary Gland Journal of Mammary Gland Biology and Neoplasia. 6: 253-273. PMID 11547896 DOI: 10.1023/A:1011367423085  0.433
2001 Chen H, Fernig DG, Rudland PS, Sparks A, Wilkinson MC, Barraclough R. Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka). Biochemical and Biophysical Research Communications. 286: 1212-7. PMID 11527429 DOI: 10.1006/Bbrc.2001.5517  0.555
2001 El-Tanani M, Fernig DG, Barraclough R, Green C, Rudland P. Differential modulation of transcriptional activity of estrogen receptors by direct protein-protein interactions with the T cell factor family of transcription factors. Journal of Biological Chemistry. 276: 41675-41682. PMID 11522780 DOI: 10.1074/Jbc.M103966200  0.568
2001 Delehedde M, Sergeant N, Lyon M, Rudland PS, Fernig DG. Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways. Febs Journal. 268: 4423-4429. PMID 11502202 DOI: 10.1046/J.1432-1327.2001.02363.X  0.536
2001 Yu LG, Milton JD, Fernig DG, Rhodes JM. Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins. Journal of Cellular Physiology. 186: 282-7. PMID 11169464 DOI: 10.1002/1097-4652(200102)186:2<282::Aid-Jcp1028>3.0.Co;2-2  0.392
2001 Yu L, Milton JD, Fernig DG, Rhodes JM. Jacktruit Lectin (Jacalin), a Thomsen-Friedenreich antigen-binding lectin, inhibits proliferation of HT29 human colon cancer cells by altering cell surface tyrosine phosphorylation and down regulating MAP kinase kinase (MEK1/2) and MAP kinase (Erk1/2) Gastroenterology. 120: A665. DOI: 10.1016/S0016-5085(08)83309-4  0.302
2000 Delehedde M, Seve M, Sergeant N, Wartelle I, Lyon M, Rudland PS, Fernig DG. Fibroblast growth factor-2 stimulation of p42/44MAPK phosphorylation and IkappaB degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts. Journal of Biological Chemistry. 275: 33905-33910. PMID 10944532 DOI: 10.1074/Jbc.M005949200  0.58
2000 Sergeant N, Lyon M, Rudland PS, Fernig DG, Delehedde M. Stimulation of DNA Synthesis and Cell Proliferation of Human Mammary Myoepithelial-like Cells by Hepatocyte Growth Factor/Scatter Factor Depends on Heparan Sulfate Proteoglycans and Sustained Phosphorylation of Mitogen-activated Protein Kinases p42/44 Journal of Biological Chemistry. 275: 17094-17099. PMID 10747885 DOI: 10.1074/Jbc.M000237200  0.591
2000 Yu L, Fernig DG, Rhodes JM. Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells Febs Journal. 267: 2122-2126. PMID 10727953 DOI: 10.1046/J.1432-1327.2000.01230.X  0.337
2000 Fernig DG, Chen H, Rahmoune H, Descamps S, Boilly B, Hondermarck H. Differential Regulation of FGF-1 and -2 Mitogenic Activity Is Related to Their Kinetics of Binding to Heparan Sulfate in MDA-MB-231 Human Breast Cancer Cells Biochemical and Biophysical Research Communications. 267: 770-776. PMID 10673367 DOI: 10.1006/Bbrc.1999.2028  0.402
2000 Brooks B, Briggs DM, Eastmond NC, Fernig DG, Coleman JW. Presentation of IFN-γ to Nitric Oxide-Producing Cells: A Novel Function for Mast Cells Journal of Immunology. 164: 573-579. PMID 10623797 DOI: 10.4049/Jimmunol.164.2.573  0.334
2000 Singh R, Yu L, Fernig DG, Delehedde M, Campbell BJ, Rhodes JM. Peanut lectin-induced proliferation of HT29 human colon cancer cells is mediated by activation of mitogen-activated protein kinase (MAPK) Gastroenterology. 118: A614. DOI: 10.1016/S0016-5085(00)84595-3  0.307
1999 Li P, Wilde CJ, Finch LM, Fernig DG, Rudland PS. Identification of cell types in the developing goat mammary gland. The Histochemical Journal. 31: 379-93. PMID 10462224 DOI: 10.1023/A:1003700224900  0.567
1999 Li P, Rudland PS, Fernig DG, Finch LM, Wilde CJ. Modulation of mammary development and programmed cell death by the frequency of milk removal in lactating goats. The Journal of Physiology. 519: 885-900. PMID 10457098 DOI: 10.1111/J.1469-7793.1999.0885N.X  0.524
1999 Vacherot F, Delbé J, Heroult M, Barritault D, Fernig DG, Courty J. Glycosaminoglycans differentially bind HARP and modulate its biological activity. Journal of Biological Chemistry. 274: 7741-7747. PMID 10075664 DOI: 10.1074/Jbc.274.12.7741  0.398
1999 Yu LG, Fernig DG, White MR, Spiller DG, Appleton P, Evans RC, Grierson I, Smith JA, Davies H, Gerasimenko OV, Petersen OH, Milton JD, Rhodes JM. Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. The Journal of Biological Chemistry. 274: 4890-9. PMID 9988731 DOI: 10.1074/Jbc.274.8.4890  0.356
1998 Li P, Barraclough R, Fernig DG, Smith JA, Rudland PS. Stem cells in breast epithelia. International Journal of Experimental Pathology. 79: 193-206. PMID 9797716 DOI: 10.1046/J.1365-2613.1998.00068.X  0.599
1998 Kinsella L, Chen HL, Smith JA, Rudland PS, Fernig DG. Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides. Glycoconjugate Journal. 15: 419-22. PMID 9613830 DOI: 10.1023/A:1006986104865  0.585
1998 Rahmoune H, Rudland PS, Gallagher JT, Fernig DG. Hepatocyte growth factor/scatter factor has distinct classes of binding site in heparan sulfate from mammary cells. Biochemistry. 37: 6003-6008. PMID 9558337 DOI: 10.1021/Bi972468T  0.603
1998 Rahmoune H, Chen H, Gallagher JT, Rudland PS, Fernig DG. Interaction of Heparan Sulfate from Mammary Cells with Acidic Fibroblast Growth Factor (FGF) and Basic FGF REGULATION OF THE ACTIVITY OF BASIC FGF BY HIGH AND LOW AFFINITY BINDING SITES IN HEPARAN SULFATE Journal of Biological Chemistry. 273: 7303-7310. PMID 9516424 DOI: 10.1074/Jbc.273.13.7303  0.58
1998 Lyon M, Deakin JA, Rahmoune H, Fernig DG, Nakamura T, Gallagher JT. Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate Journal of Biological Chemistry. 273: 271-278. PMID 9417075 DOI: 10.1074/Jbc.273.1.271  0.371
1998 Milton J, Yu L, Fernig D, Rhodes J. The binding characteristics and effects on nuclear protein import in HT29 colon cancer cells of four dietary TF-binding lectins with contrasting effects on epithelial proliferation Gastroenterology. 114. DOI: 10.1016/S0016-5085(98)82632-2  0.346
1997 Yu LG, Jansson B, Fernig DG, Milton JD, Smith JA, Gerasimenko OV, Jones M, Rhodes JM. Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine). International Journal of Cancer. Journal International Du Cancer. 73: 424-31. PMID 9359491 DOI: 10.1002/(Sici)1097-0215(19971104)73:3<424::Aid-Ijc18>3.0.Co;2-C  0.328
1997 Galzie Z, Fernig DG, Smith JA, Poston GJ, Kinsella AR. Invasion of human colorectal carcinoma cells is promoted by endogenous basic fibroblast growth factor. International Journal of Cancer. 71: 390-395. PMID 9139874 DOI: 10.1002/(Sici)1097-0215(19970502)71:3<390::Aid-Ijc15>3.0.Co;2-K  0.398
1997 Rahmoune H, Turnbull JE, Gallagher JT, Rudland PS, Fernig DG. Heparan sulphate in breast cancer cells. Biochemical Society Transactions. 24: 355S. PMID 8878899 DOI: 10.1042/Bst024355S  0.501
1997 Rudland PS, Barraclough R, Fernig DG, Smith JA. 7 – Mammary stem cells in normal development and cancer Stem Cells. 147-232. DOI: 10.1016/B978-012563455-7/50008-8  0.562
1996 Galzie Z, Fernig DG, Smith JA, Poston GJ, Kinsella AR. Basic fibroblast growth factor and colorectal carcinoma invasion Biochemical Society Transactions. 24. PMID 8879045 DOI: 10.1042/Bst024501S  0.311
1996 Chen H, Smith JA, Rudland PS, Fernig DG. Potentiation of the growth-stimulatory effects of aFGF by heparin in Rama 27 fibroblasts. Biochemical Society Transactions. 24. PMID 8878902 DOI: 10.1042/Bst024358S  0.545
1996 Li P, Fernig DG, Rudland PS, Finch LM, Wilde CJ. Identification of cell types in the developing goat mammary gland. Biochemical Society Transactions. 24: 357S. PMID 8878901 DOI: 10.1042/Bst024357S  0.536
1996 Chen H, Rudland PS, Smith JA, Fernig DG. Late signals are required for the stimulation of DNA synthesis in rat mammary fibroblasts by growth factors. Bioscience Reports. 16: 249-263. PMID 8842375 DOI: 10.1007/Bf01207339  0.556
1996 Davies BR, Fernig DG, Barraclough R, Rudland PS. Effect on tumorigenicity and metastasis of transfection of a diploid benign rat mammary epithelial cell line with DNA corresponding to the mRNA for basic fibroblast growth factor International Journal of Cancer. 65: 104-111. PMID 8543386 DOI: 10.1002/(Sici)1097-0215(19960103)65:1<104::Aid-Ijc18>3.0.Co;2-G  0.613
1995 Rudland P, Fernig D, Smith J. Growth factors and their receptors in neoplastic mammary glands. Biomedicine & Pharmacotherapy. 49: 389-399. PMID 8746075 DOI: 10.1016/0753-3322(96)82676-X  0.598
1995 Yu LG, Evans RC, Davies H, Ward S, Miller G, Grierson I, Fernig DG, Smith JA, Milton JD, Rhodes JM. Demonstration of Internalization and Nuclear Incorporation of the Growth Inhibitory Lectin from Edible Mushroom Clinical Science. 88. DOI: 10.1042/Cs088011Pa  0.319
1994 McAndrew J, Fernig DG, Rudland PS, Smith JA. Secretion of transforming growth factor alpha and expression of its receptor in human mammary cell lines. Growth Factors Journal. 10: 281-287. PMID 7803044 DOI: 10.3109/08977199409010994  0.599
1994 Fernig DG, Gallagher JT. Fibroblast growth factors and their receptors: an information network controlling tissue growth, morphogenesis and repair. Progress in Growth Factor Research. 5: 353-377. PMID 7780086 DOI: 10.1016/0955-2235(94)00007-8  0.401
1994 Pearce A, Durkin AF, Fisher MJ, Rees HH, Taylor CF, Fernig DG. A Novel Tyrosine Kinase Activity In The Cotton Leafworm, Spodoptera Littoralis Comparative Biochemistry and Physiology B. 109: 253-259. DOI: 10.1016/0305-0491(94)90009-4  0.321
1993 Fernig DG, Barraclough R, Ke Y, Wilkinson MC, Rudland PS, Smith JA. Ectopic production of heparin-binding growth factors and receptors for basic fibroblast growth factor by rat mammary epithelial cell lines derived from malignant metastatic tumours. International Journal of Cancer. 54: 629-635. PMID 8514454 DOI: 10.1002/Ijc.2910540418  0.616
1993 Rudland PS, Platt-Higgins AM, Wilkinson MC, Fernig DG. Immunocytochemical identification of basic fibroblast growth factor in the developing rat mammary gland: variations in location are dependent on glandular structure and differentiation.: Journal of Histochemistry and Cytochemistry. 41: 887-898. PMID 7686196 DOI: 10.1177/41.6.7686196  0.577
1993 Turnbull JE, Fernig DG, Walker A, Gallagher JT. S5.2 FGF-binding sequences in heparan sulphate: Structural characterisation and regulation of FGF activity Glycoconjugate Journal. 10: 250-250. DOI: 10.1007/Bf01209898  0.314
1992 Ke Y, Wilkinson MC, Fernig DG, Smith JA, Rudland PS, Barraclough R. A rapid procedure for production of human basic fibroblast growth factor in Escherichia coli cells. Biochimica Et Biophysica Acta. 1131: 307-310. PMID 1627646 DOI: 10.1016/0167-4781(92)90029-Y  0.571
1992 Fernig DG, Rudland PS, Smith JA. Rat mammary myoepithelial-like cells in culture possess kinetically distinct low-affinity receptors for fibroblast growth factor that modulate growth stimulatory responses. Growth Factors Journal. 7: 27-39. PMID 1323979 DOI: 10.3109/08977199209023935  0.599
1991 Fernig DG, Smith JA, Rudland PS. Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland. Cancer Treatment and Research. 53: 47-78. PMID 1672090 DOI: 10.1007/978-1-4615-3940-7_3  0.566
1990 Barraclough R, Fernig DG, Rudland PS, Smith JA. Synthesis of basic fibroblast growth factor upon differentiation of rat mammary epithelial to myoepithelial-like cells in culture. Journal of Cellular Physiology. 144: 333-344. PMID 2166060 DOI: 10.1002/Jcp.1041440220  0.588
1990 Fernig DG, Smith JA, Rudland PS. Appearance of basic fibroblast growth factor receptors upon differentiation of rat mammary epithelial to myoepithelial-like cells in culture. Journal of Cellular Physiology. 142: 108-116. PMID 2153686 DOI: 10.1002/Jcp.1041420114  0.622
1990 Ke Y, Fernig DG, Smith JA, Wilkinson MC, Anandappa SY, Rudland PS, Barraclough R. High-level production of human acidic fibroblast growth factor in E. coli cells: inhibition of DNA synthesis in rat mammary fibroblasts at high concentrations of growth factor. Biochemical and Biophysical Research Communications. 171: 963-971. PMID 1699532 DOI: 10.1016/0006-291X(90)90778-L  0.608
1989 Smith JA, Barraclough R, Fernig DG, Rudland PS. Identification of alpha transforming growth factor as a possible local trophic agent for the mammary gland. Journal of Cellular Physiology. 141: 362-370. PMID 2808543 DOI: 10.1002/Jcp.1041410218  0.555
1987 Fernig DG, Mayer RJ. Degradation of nuclear proteins: studies on transplanted B82 cell karyoplast proteins Febs Letters. 210: 165-168. PMID 3025024 DOI: 10.1016/0014-5793(87)81329-7  0.513
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