Peter W Lewis - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jain SU, Khazaei S, Marchione DM, Lundgren SM, Wang X, Weinberg DN, Deshmukh S, Juretic N, Lu C, Allis CD, Garcia BA, Jabado N, Lewis PW. Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression. Proceedings of the National Academy of Sciences of the United States of America. PMID 33067396 DOI: 10.1073/pnas.2006076117  0.8
2020 Jain SU, Rashoff AQ, Krabbenhoft SD, Hoelper D, Do TJ, Gibson TJ, Lundgren SM, Bondra ER, Deshmukh S, Harutyunyan AS, Juretic N, Jabado N, Harrison MM, Lewis PW. H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2. Molecular Cell. PMID 33049227 DOI: 10.1016/j.molcel.2020.09.028  0.64
2020 Khazaei S, De Jay N, Deshmukh S, Hendrikse LD, Jawhar W, Chen CC, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil E, Ishii T, Jain SU, Rossokhata K, Sihota TS, ... ... Lewis PW, et al. H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone. Cancer Discovery. PMID 32967858 DOI: 10.1158/2159-8290.CD-20-0461  0.64
2019 Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, ... ... Lewis PW, et al. Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Cancer Cell. 36: 338-339. PMID 31526762 DOI: 10.1016/j.ccell.2019.08.012  0.6
2019 Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nature Communications. 10: 2146. PMID 31086175 DOI: 10.1038/S41467-019-09981-6  0.64
2019 Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, ... ... Lewis PW, et al. Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Cancer Cell. 35: 782-797.e8. PMID 31085178 DOI: 10.1016/J.Ccell.2019.04.004  0.6
2019 Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 30967505 DOI: 10.1073/Pnas.1819029116  0.64
2019 Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, ... ... Lewis PW, et al. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Nature Communications. 10: 1262. PMID 30890717 DOI: 10.1038/S41467-019-09140-X  0.64
2019 McDaniel SL, Gibson TJ, Schulz KN, Fernandez Garcia M, Nevil M, Jain SU, Lewis PW, Zaret KS, Harrison MM. Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Molecular Cell. PMID 30797686 DOI: 10.1016/J.Molcel.2019.01.014  0.64
2019 Strekalova E, Malin D, Weisenhorn EMM, Russell JD, Hoelper D, Jain A, Coon JJ, Lewis PW, Cryns VL. S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells. Breast Cancer Research and Treatment. PMID 30712196 DOI: 10.1007/S10549-019-05146-7  0.52
2018 Chan CS, Laddha SV, Lewis PW, Koletsky MS, Robzyk K, Da Silva E, Torres PJ, Untch BR, Li J, Bose P, Chan TA, Klimstra DS, Allis CD, Tang LH. ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup. Nature Communications. 9: 4158. PMID 30315258 DOI: 10.1038/S41467-018-06498-2  0.8
2018 Lu C, Jain S, Hoelper D, Bechet D, Ran L, Andrulis I, Dickson B, Majewski J, Thompson C, Chi P, Garcia B, Jabado N, Lewis P, Allis CD. Abstract PR12: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Sarcomas17-Pr12  0.8
2018 Strekalova E, Malin D, Hoelper D, Lewis P, Cryns V. Abstract LB-247: Targeting methionine metabolism to eradicate cancer stem cells Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-247  0.52
2017 Hoelper D, Huang H, Jain AY, Patel DJ, Lewis PW. Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX. Nature Communications. 8: 1193. PMID 29084956 DOI: 10.1038/S41467-017-01206-Y  0.52
2017 Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, et al. Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nature Genetics. PMID 28067913 DOI: 10.1038/Ng.3757  0.8
2017 Lu C, Papillon-Cavanagh S, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu O, Dhaliwal S, et al. Abstract 08: Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas Clinical Cancer Research. 23: 8-8. DOI: 10.1158/1557-3265.Aacrahns17-08  0.8
2017 Venneti S, Bayliss J, Mukherjee P, Lu C, Jain S, Chung C, Martinez D, Sabari B, Margol A, Panwalkar P, Paroloia A, Pekmezci M, Eachin RM, Cieslik M, Tamrazi B, ... ... Lewis P, et al. Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas Cancer Research. 77: 3863-3863. DOI: 10.1158/1538-7445.Am2017-3863  0.8
2016 Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, ... ... Lewis PW, et al. Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas. Science Translational Medicine. 8: 366ra161. PMID 27881822 DOI: 10.1126/Scitranslmed.Aah6904  0.64
2016 Jayaram H, Hoelper D, Jain SU, Cantone N, Lundgren SM, Poy F, Allis CD, Cummings R, Bellon S, Lewis PW. S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proceedings of the National Academy of Sciences of the United States of America. PMID 27185940 DOI: 10.1073/Pnas.1605523113  0.8
2016 Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, ... ... Lewis PW, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science (New York, N.Y.). 352: 844-9. PMID 27174990 DOI: 10.1126/Science.Aac7272  1
2015 Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW. Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin. Angewandte Chemie (International Ed. in English). 54: 6457-61. PMID 25873363 DOI: 10.1002/Anie.201500085  1
2015 Noh KM, Maze I, Zhao D, Xiang B, Wenderski W, Lewis PW, Shen L, Li H, Allis CD. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons. Proceedings of the National Academy of Sciences of the United States of America. 112: 6820-7. PMID 25538301 DOI: 10.1073/Pnas.1411258112  1
2014 Funato K, Major T, Lewis PW, Allis CD, Tabar V. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science (New York, N.Y.). 346: 1529-33. PMID 25525250 DOI: 10.1126/Science.1253799  1
2014 Venneti S, Santi M, Felicella MM, Yarilin D, Phillips JJ, Sullivan LM, Martinez D, Perry A, Lewis PW, Thompson CB, Judkins AR. A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas. Acta Neuropathologica. 128: 743-53. PMID 25200322 DOI: 10.1007/S00401-014-1338-3  1
2014 Bechet D, Gielen GG, Korshunov A, Pfister SM, Rousso C, Faury D, Fiset PO, Benlimane N, Lewis PW, Lu C, David Allis C, Kieran MW, Ligon KL, Pietsch T, Ellezam B, et al. Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas. Acta Neuropathologica. 128: 733-41. PMID 25200321 DOI: 10.1007/S00401-014-1337-4  1
2014 Brown ZZ, Müller MM, Jain SU, Allis CD, Lewis PW, Muir TW. Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. Journal of the American Chemical Society. 136: 13498-501. PMID 25180930 DOI: 10.1021/Ja5060934  1
2014 Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U, Zuccaro J, Agnihotri S, Ryall S, Barszczyk M, Chornenkyy Y, et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nature Genetics. 46: 451-6. PMID 24705254 DOI: 10.1038/Ng.2936  1
2013 Lewis PW, Allis CD. Poisoning the "histone code" in pediatric gliomagenesis. Cell Cycle (Georgetown, Tex.). 12: 3241-2. PMID 24036540 DOI: 10.4161/Cc.26356  1
2013 Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, et al. KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell. 154: 541-55. PMID 23871696 DOI: 10.1016/J.Cell.2013.06.051  1
2013 Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (New York, N.Y.). 340: 857-61. PMID 23539183 DOI: 10.1126/Science.1232245  1
2012 Elsässer SJ, Huang H, Lewis PW, Chin JW, Allis CD, Patel DJ. DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature. 491: 560-5. PMID 23075851 DOI: 10.1038/Nature11608  1
2012 Lewis PW, Sahoo D, Geng C, Bell M, Lipsick JS, Botchan MR. Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Molecular and Cellular Biology. 32: 3218-27. PMID 22688510 DOI: 10.1128/Mcb.00432-12  1
2011 Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature Structural & Molecular Biology. 18: 769-76. PMID 21666679 DOI: 10.1038/Nsmb.2062  1
2011 Elsässer SJ, Allis CD, Lewis PW. Cancer. New epigenetic drivers of cancers. Science (New York, N.Y.). 331: 1145-6. PMID 21385704 DOI: 10.1126/Science.1203280  1
2010 Banaszynski LA, Allis CD, Lewis PW. Histone variants in metazoan development. Developmental Cell. 19: 662-74. PMID 21074717 DOI: 10.1016/J.Devcel.2010.10.014  1
2010 Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proceedings of the National Academy of Sciences of the United States of America. 107: 14075-80. PMID 20651253 DOI: 10.1073/Pnas.1008850107  1
2010 Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 140: 678-91. PMID 20211137 DOI: 10.1016/J.Cell.2010.01.003  1
2007 Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Bell SP, Speed T, Manak JR, Botchan MR. Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes & Development. 21: 2880-96. PMID 17978103 DOI: 10.1101/Gad.1600107  1
2007 Beall EL, Lewis PW, Bell M, Rocha M, Jones DL, Botchan MR. Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes & Development. 21: 904-19. PMID 17403774 DOI: 10.1101/gad.1516607  1
2006 Moyer SE, Lewis PW, Botchan MR. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proceedings of the National Academy of Sciences of the United States of America. 103: 10236-41. PMID 16798881 DOI: 10.1073/Pnas.0602400103  1
2004 Lewis PW, Beall EL, Fleischer TC, Georlette D, Link AJ, Botchan MR. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes & Development. 18: 2929-40. PMID 15545624 DOI: 10.1101/Gad.1255204  1
2004 Johnson JS, Osheim YN, Xue Y, Emanuel MR, Lewis PW, Bankovich A, Beyer AL, Engel DA. Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A. Journal of Virology. 78: 6459-68. PMID 15163739 DOI: 10.1128/Jvi.78.12.6459-6468.2004  1
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