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Lawrence Kazak - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Mitochondria, thermogenesis, adipocyte biology
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kazak L. Promoting metabolic inefficiency for metabolic disease. Iscience. 26: 107843. PMID 37736043 DOI: 10.1016/j.isci.2023.107843  0.314
2022 Rahbani JF, Scholtes C, Lagarde DM, Hussain MF, Roesler A, Dykstra CB, Bunk J, Samborska B, O'Brien SL, Tripp E, Pacis A, Angueira AR, Johansen OS, Cinkornpumin J, Hossain I, ... ... Kazak L, et al. ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP. Nature Metabolism. PMID 36344764 DOI: 10.1038/s42255-022-00667-w  0.567
2022 Rahbani JF, Kazak L. A brown fat-selective mechanism of mitochondrial calcium import? Cell Metabolism. 34: 1231-1233. PMID 36070679 DOI: 10.1016/j.cmet.2022.08.011  0.358
2022 Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Mitochondrial uncouplers induce proton leak by activating AAC and UCP1. Nature. 606: 180-187. PMID 35614225 DOI: 10.1038/s41586-022-04747-5  0.689
2022 Rahbani JF, Chouchani ET, Spiegelman BM, Kazak L. Measurement of Futile Creatine Cycling Using Respirometry. Methods in Molecular Biology (Clifton, N.J.). 2448: 141-153. PMID 35167096 DOI: 10.1007/978-1-0716-2087-8_10  0.746
2021 Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, ... Kazak L, et al. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. PMID 33981039 DOI: 10.1038/s41586-021-03533-z  0.807
2021 Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L. Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature. 590: 480-485. PMID 33597756 DOI: 10.1038/s41586-021-03221-y  0.606
2021 Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, ... ... Kazak L, et al. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metabolism. PMID 33596409 DOI: 10.1016/j.cmet.2021.01.018  0.459
2021 Connell NJ, Doligkeit D, Andriessen C, Kornips-Moonen E, Bruls YMH, Schrauwen-Hinderling VB, van de Weijer T, van Marken-Lichtenbelt WD, Havekes B, Kazak L, Spiegelman BM, Hoeks J, Schrauwen P. No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians. Nature Metabolism. 3: 107-117. PMID 33462512 DOI: 10.1038/s42255-020-00332-0  0.45
2020 Kazak L, Spiegelman BM. Mechanism of futile creatine cycling in thermogenesis. American Journal of Physiology. Endocrinology and Metabolism. PMID 32954828 DOI: 10.1152/Ajpendo.00444.2020  0.478
2020 Kazak L, Cohen P. Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature Reviews. Endocrinology. PMID 32493980 DOI: 10.1038/S41574-020-0365-5  0.52
2020 Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM. Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32358195 DOI: 10.1073/Pnas.2001387117  0.736
2020 Hussain MF, Roesler A, Kazak L. Regulation of adipocyte thermogenesis: mechanisms controlling obesity. The Febs Journal. PMID 32301220 DOI: 10.1111/febs.15331  0.351
2020 Roesler A, Kazak L. UCP1-independent thermogenesis. The Biochemical Journal. 477: 709-725. PMID 32059055 DOI: 10.1042/BCJ20190463  0.377
2020 Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace D, Spiegelman BM, Kirichok YV. Molecular Identity and Regulatory Mechanisms of the Mitochondrial Uncoupling Protein of Non-Adipose Tissues Biophysical Journal. 118: 185a. DOI: 10.1016/J.Bpj.2019.11.1127  0.809
2019 Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. H transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 571: 515-520. PMID 31341297 DOI: 10.1038/S41586-019-1400-3  0.793
2019 Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, et al. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nature Metabolism. 1: 360-370. PMID 31161155 DOI: 10.1038/s42255-019-0035-x  0.764
2019 Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, et al. An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metabolism. PMID 31105043 DOI: 10.1016/J.Cmet.2019.04.013  0.732
2018 Chouchani ET, Kazak L, Spiegelman BM. New Advances in Adaptive Thermogenesis: UCP1 and Beyond. Cell Metabolism. PMID 30503034 DOI: 10.1016/J.Cmet.2018.11.002  0.752
2018 Cluett TJ, Akman G, Reyes A, Kazak L, Mitchell A, Wood SR, Spinazzola A, Spelbrink JN, Holt IJ. Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication. Nucleic Acids Research. PMID 30239839 DOI: 10.1093/Nar/Gky852  0.623
2018 Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism. PMID 30078553 DOI: 10.1016/J.Cmet.2018.07.004  0.682
2018 Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. PMID 30022159 DOI: 10.1038/S41586-018-0353-2  0.779
2018 Paulo JA, Jedrychowski MP, Chouchani ET, Kazak L, Gygi SP. Multiplexed isobaric tag-based profiling of seven murine tissues following in vivo nicotine treatment using a minimalistic proteomics strategy. Proteomics. e1700326. PMID 29660237 DOI: 10.1002/Pmic.201700326  0.649
2018 Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29295932 DOI: 10.1073/Pnas.1717776115  0.602
2018 Bertholet AM, Fedorenko A, Chouchani ET, Kazak L, Angelin A, Vidoni S, Cho J, Terada N, Spiegelman BM, Wallace DC, Kirichok Y. Molecular Identity and Regulatory Mechanisms of the Mitochondrial Uncoupling Protein of Regular Somatic Tissues Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e50. DOI: 10.1016/J.Bbabio.2018.09.150  0.759
2017 Palmer CJ, Bruckner RJ, Paulo JA, Kazak L, Long JZ, Mina AI, Deng Z, LeClair KB, Hall JA, Hong S, Zushin PH, Smith KL, Gygi SP, Hagen S, Cohen DE, et al. Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue. Molecular Metabolism. 6: 1212-1225. PMID 29031721 DOI: 10.1016/J.Molmet.2017.07.013  0.725
2017 Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism. 26: 693. PMID 28978428 DOI: 10.1016/J.Cmet.2017.09.007  0.782
2017 Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism. PMID 28844881 DOI: 10.1016/J.Cmet.2017.08.009  0.802
2017 Chouchani ET, Kazak L, Spiegelman BM. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms. The Journal of Biological Chemistry. PMID 28842500 DOI: 10.1074/Jbc.R117.789628  0.776
2017 Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630339 DOI: 10.1073/Pnas.1705406114  0.806
2017 Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metabolism. 25: 811-822.e4. PMID 28380374 DOI: 10.1016/J.Bbabio.2018.09.358  0.786
2017 Kazak L. Bioenergetic Analyses in Adipose Tissue. Methods in Molecular Biology (Clifton, N.J.). 1566: 125-134. PMID 28244046 DOI: 10.1007/978-1-4939-6820-6_12  0.455
2016 Liyanage SU, Coyaud E, Laurent EM, Hurren R, Maclean N, Wood SR, Kazak L, Shamas-Din A, Holt I, Raught B, Schimmer A. Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria. Mitochondrion. PMID 27845271 DOI: 10.1016/J.Mito.2016.11.001  0.633
2016 Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED. IRF3 promotes adipose inflammation and insulin resistance and represses browning. The Journal of Clinical Investigation. PMID 27400129 DOI: 10.1172/Jci86080  0.641
2016 Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. PMID 27281219 DOI: 10.1038/Nature18279  0.705
2016 Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. PMID 27027295 DOI: 10.1038/Nature17399  0.795
2016 Holt IJ, Kazak L, Reyes A, Wood SR. Analysis of Replicating Mitochondrial DNA by In Organello Labeling and Two-Dimensional Agarose Gel Electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 1351: 95-113. PMID 26530677 DOI: 10.1007/978-1-4939-3040-1_8  0.588
2015 Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat. Cell. 163: 643-55. PMID 26496606 DOI: 10.1016/J.Cell.2015.09.035  0.821
2014 Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 513: 100-4. PMID 25043053 DOI: 10.1038/Nature13528  0.649
2014 Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, et al. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 158: 69-83. PMID 24995979 DOI: 10.1016/J.Cell.2014.04.049  0.735
2013 Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12480-5. PMID 23818608 DOI: 10.1073/Pnas.1310261110  0.751
2013 Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ. A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. Plos One. 8: e62340. PMID 23675412 DOI: 10.1371/Journal.Pone.0062340  0.608
2013 Reyes A, Kazak L, Wood SR, Yasukawa T, Jacobs HT, Holt IJ. Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Research. 41: 5837-50. PMID 23595151 DOI: 10.1093/Nar/Gkt196  0.595
2013 Kazak L, Reyes A, Duncan AL, Rorbach J, Wood SR, Brea-Calvo G, Gammage PA, Robinson AJ, Minczuk M, Holt IJ. Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Research. 41: 2354-69. PMID 23275553 DOI: 10.1093/Nar/Gks1347  0.67
2012 Kazak L, Reyes A, Holt IJ. Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nature Reviews. Molecular Cell Biology. 13: 659-71. PMID 22992591 DOI: 10.1038/Nrm3439  0.607
2012 He J, Cooper HM, Reyes A, Di Re M, Kazak L, Wood SR, Mao CC, Fearnley IM, Walker JE, Holt IJ. Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit. Nucleic Acids Research. 40: 6097-108. PMID 22447445 DOI: 10.1093/Nar/Gks257  0.66
2012 Kazak L, Reyes A, Wood SR, Holt IJ. A mitochondrial isoform of FEN1 functions as a tailed R-loop binding protein and associates with early mitochondrial DNA replication intermediates F1000research. 3. DOI: 10.7490/F1000Research.1092211.1  0.431
2012 Kazak L, Reyes A, Holt IJ. Erratum: Minimizing the damage: repair pathways keep mitochondrial DNA intact Nature Reviews Molecular Cell Biology. 13: 726-726. DOI: 10.1038/Nrm3458  0.412
2011 Vainshtein A, Kazak L, Hood DA. Effects of endurance training on apoptotic susceptibility in striated muscle. Journal of Applied Physiology (Bethesda, Md. : 1985). 110: 1638-45. PMID 21474699 DOI: 10.1152/Japplphysiol.00020.2011  0.373
2011 Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, et al. Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Research. 39: 5098-108. PMID 21398640 DOI: 10.1093/Nar/Gkr052  0.636
2011 Reyes A, He J, Mao C, Bailey L, Re MD, Sembongi H, Kazak L, Dzionek K, Holmes J, Cluett T, Harbour M, Fearnley I, Crouch R, Conti M, Adelstein R, et al. Actomyosin & mitochondrial DNA maintenance F1000research. 2. DOI: 10.7490/F1000Research.955.1  0.421
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