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Kenton Jon Swartz, PhD - Publications

Affiliations: 
1997- NINDS National Institutes of Health, Bethesda, MD 
Area:
Ion channels
Website:
https://neuroscience.nih.gov/Faculty/Profile/kenton-swartz.aspx
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154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ. Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms. Elife. 9. PMID 32804077 DOI: 10.7554/Elife.58660  0.593
2020 Ballesteros A, Swartz KJ. Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells. Journal of Visualized Experiments. PMID 32090986 DOI: 10.3791/60769  0.409
2020 Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ. Author response: Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms Elife. DOI: 10.7554/Elife.58660.Sa2  0.522
2020 George BI, Swartz K, Li M. Hearing Loss Mutations Alter the Functional Properties of Human P2X2 Receptor Channels Through Distinct Mechanisms Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.3175  0.743
2020 Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz K. Making Sense of TRP Channel Structures Biophysical Journal. 118: 22a-23a. DOI: 10.1016/J.Bpj.2019.11.303  0.575
2020 Matthies D, Qiu B, Bae C, Perozo E, Swartz K, Subramaniam S, Boudker O, Yu Z. Single-particle Cryo-EM of Membrane Proteins - Success Stories and Current Challenges Biophysical Journal. 118: 13a. DOI: 10.1016/J.Bpj.2019.11.253  0.304
2020 Jara-Oseguera A, Huffer KE, Swartz KJ. The Selectivity Filter of the TRPV1 Channel Does Not Function as an Activation Gate Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2326  0.494
2020 Fernández-Mariño AI, Swartz K. Conserved Voltage-Dependent Gating Elements between Shaker and HERG Kv Channels Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1855  0.58
2020 Gupta K, Toombes GES, Swartz KJ. Exploring Structural Dynamics of a Membrane Protein by Combining Bioorthogonal Chemistry and Cysteine Mutagenesis Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1036  0.323
2019 Jara-Oseguera A, Huffer KE, Swartz KJ. The ion selectivity filter is not an activation gate in TRPV1-3 channels. Elife. 8. PMID 31724952 DOI: 10.7554/Elife.51212  0.529
2019 Gupta K, Toombes GE, Swartz KJ. Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis. Elife. 8. PMID 31714877 DOI: 10.7554/Elife.50776  0.481
2019 George B, Swartz KJ, Li M. Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America. PMID 31636190 DOI: 10.1073/Pnas.1912156116  0.784
2019 Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ. Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. Elife. 8. PMID 31232692 DOI: 10.7554/Elife.47060  0.782
2019 Papp F, Lomash S, Szilagyi O, Babikow E, Smith J, Chang TH, Bahamonde MI, Toombes GES, Swartz KJ. TMEM266 is a functional voltage sensor regulated by extracellular Zn. Elife. 8. PMID 30810529 DOI: 10.7554/Elife.42372  0.843
2019 Zhang F, Swartz KJ, Jara-Oseguera A. Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity. Elife. 8. PMID 30644819 DOI: 10.1016/J.Bpj.2018.11.2881  0.58
2019 Jara-Oseguera A, Huffer KE, Swartz KJ. Author response: The ion selectivity filter is not an activation gate in TRPV1-3 channels Elife. DOI: 10.7554/Elife.51212.Sa2  0.496
2019 Gupta K, Toombes GE, Swartz KJ. Author response: Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis Elife. DOI: 10.7554/Elife.50776.025  0.317
2019 Yellen G, Swartz KJ. Decision letter: Regulation of Eag1 gating by its intracellular domains Elife. DOI: 10.7554/Elife.49188.025  0.344
2019 Swartz KJ, Lipscombe D. Decision letter: Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation Elife. DOI: 10.7554/Elife.48118.Sa1  0.416
2019 Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ. Author response: Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP Elife. DOI: 10.7554/Elife.47060.029  0.772
2019 Papp F, Lomash S, Szilagyi O, Babikow E, Smith J, Chang T, Bahamonde MI, Toombes GES, Swartz KJ. Author response: TMEM266 is a functional voltage sensor regulated by extracellular Zn2+ Elife. DOI: 10.7554/Elife.42372.023  0.77
2019 George BI, Li M, Swartz KJ. Characterizing P2X2 Mutants Associated with Progressive Sensorineural Hearing Loss (DFNA41) Biophysical Journal. 116: 109a. DOI: 10.1016/J.Bpj.2018.11.623  0.631
2019 Gupta K, Toombes GES, Swartz KJ. Using Click Chemistry and Voltage Clamp Fluorimetry to Study Structural Dynamics of Membrane Proteins Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2913  0.392
2019 Fernández-Mariño AI, Swartz KJ. Identifying Common Structural Features for Electromechanical Coupling between Domain-Swapped and Non-Domain Swapped Potassium Channels Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2909  0.472
2019 Gochman A, Jara-Oseguera A, Swartz K. Cannabidiol Directly Activates TRPV2 Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2898  0.318
2019 Morcillo AB, Fenollar-Ferrer MC, Swartz KJ. Structural Relationship between the Putative Hair Cell Mechanotransduction Channel TMC1 and TMEM16 Proteins Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2485  0.506
2019 Li M, Wang Y, Silberberg SD, Hattori M, Swartz K. A Critical Mobile Divalent Cation Site in the ATP-Binding Pocket of P2X3 Receptors that Controls Channel Gating Biophysical Journal. 116: 36a. DOI: 10.1016/J.Bpj.2018.11.238  0.774
2018 Matthies D, Bae C, Toombes GE, Fox T, Bartesaghi A, Subramaniam S, Swartz KJ. Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs. Elife. 7. PMID 30109985 DOI: 10.7554/Elife.37558  0.612
2018 Ballesteros A, Fenollar-Ferrer C, Swartz KJ. Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins. Elife. 7. PMID 30063209 DOI: 10.7554/Elife.38433  0.598
2018 Ballesteros A, Swartz KJ. Lipids surf the groove in scramblases. Proceedings of the National Academy of Sciences of the United States of America. 115: 7648-7650. PMID 29980647 DOI: 10.1073/Pnas.1809472115  0.349
2018 Bae C, Jara-Oseguera A, Swartz KJ. TRPM channels come into focus. Science (New York, N.Y.). 359: 160-161. PMID 29326261 DOI: 10.1126/Science.Aar6205  0.546
2018 Zhang F, Swartz KJ, Jara-Oseguera A. Author response: Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity Elife. DOI: 10.7554/Elife.42756.017  0.352
2018 Swartz KJ, Shyng S, Goldschen-Ohm MP. Decision letter: Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding Elife. DOI: 10.7554/Elife.41103.027  0.466
2018 Ballesteros A, Fenollar-Ferrer C, Swartz KJ. Author response: Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins Elife. DOI: 10.7554/Elife.38433.039  0.488
2018 Matthies D, Bae C, Toombes GE, Fox T, Bartesaghi A, Subramaniam S, Swartz KJ. Author response: Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs Elife. DOI: 10.7554/Elife.37558.031  0.532
2018 Li M, Silberberg SD, Swartz KJ. Magnesium Modulation of P2X Receptor Channels Biophysical Journal. 114: 126a-127a. DOI: 10.1016/J.Bpj.2017.11.720  0.784
2018 George BI, Li M, Swartz KJ. Characterization of Hearing Loss-Related Mutations in ATP-Activated Ion Channels Biophysical Journal. 114: 126a. DOI: 10.1016/J.Bpj.2017.11.719  0.757
2018 Jara-Oseguera A, Swartz KJ. The Role of the Selectivity Filter in TRPV1 Channel Gating Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2191  0.487
2017 Zhang F, Jara-Oseguera A, Chang TH, Bae C, Hanson SM, Swartz KJ. Heat activation is intrinsic to the pore domain of TRPV1. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279388 DOI: 10.1073/Pnas.1717192115  0.63
2017 Chavan T, Maduke M, Swartz K. Protein ligands for studying ion channel proteins. The Journal of General Physiology. PMID 28270405 DOI: 10.1085/Jgp.201711776  0.473
2017 Swartz KJ. Decision letter: Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells Elife. DOI: 10.7554/Elife.33149.014  0.429
2017 Jara-Oseguera A, Swartz KJ. Investigating the Putative Activation Gate in the Selectivity Filter of the TRPV1 Channel Biophysical Journal. 112: 114. DOI: 10.1016/J.Bpj.2016.11.645  0.592
2017 Huffer KE, Jara-Oseguera A, Swartz KJ. Transfer of TRPV1 Sodium Binding Site into TRPV2 Biophysical Journal. 112: 114a. DOI: 10.1016/J.Bpj.2016.11.644  0.495
2017 Zhang F, Hanson S, Andres Jara-Oseguera A, Swartz K. Localization of the Temperature Sensors to the Pore Domain of the TRPV1 Channel Biophysical Journal. 112: 114a. DOI: 10.1016/J.Bpj.2016.11.643  0.639
2017 Morcillo AB, Swartz K. Expression and Characterization of the Putative Mechanosensitive Transmembrane Channel-Like Protein 1 Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2891  0.524
2017 Toombes GE, Li M, Silberberg SD, Swartz KJ. Got Ion Accumulation or Depletion (In Your Recording)? Biophysical Journal. 112: 249a. DOI: 10.1016/J.Bpj.2016.11.1358  0.67
2017 Gupta K, Swartz KJ. Using Unnatural Amino Acids to Probe the Interaction between Tarantula Toxins and Voltage Sensing Domains in KV Channels Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1343  0.652
2016 Toombes GE, Swartz KJ. STRUCTURAL BIOLOGY. Twists and turns in gating ion channels with voltage. Science (New York, N.Y.). 353: 646-7. PMID 27516583 DOI: 10.1126/Science.Aah4194  0.605
2016 Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. Engineering vanilloid-sensitivity into the rat TRPV2 channel. Elife. 5. PMID 27177419 DOI: 10.7554/Elife.16409  0.829
2016 Jara-Oseguera A, Bae C, Swartz KJ. An external sodium ion binding site controls allosteric gating in TRPV1 channels. Elife. 5. PMID 26882503 DOI: 10.7554/Elife.13356  0.58
2016 Bae C, Anselmi C, Kalia J, Jara-Oseguera A, Schwieters CD, Krepkiy D, Won Lee C, Kim EH, Kim JI, Faraldo-Gómez JD, Swartz KJ. Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin. Elife. 5. PMID 26880553 DOI: 10.7554/Elife.11273  0.875
2016 Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. Author response: Engineering vanilloid-sensitivity into the rat TRPV2 channel Elife. DOI: 10.7554/Elife.16409.015  0.786
2016 Jara-Oseguera A, Bae C, Swartz KJ. Author response: An external sodium ion binding site controls allosteric gating in TRPV1 channels Elife. DOI: 10.7554/Elife.13356.036  0.522
2016 Papp F, Smith J, Szilagyi O, Chang T, Swartz KJ. Characterization of a Fast Voltage-Sensing Protein using Voltage-Clamp Fluorometry Biophysical Journal. 110: 103. DOI: 10.1016/J.Bpj.2015.11.613  0.533
2016 Li M, Silberberg SD, Swartz KJ. Expression Level Dependence of the Gating and Permeation Properties of P2X Receptor Channels Biophysical Journal. 110: 287a. DOI: 10.1016/J.Bpj.2015.11.1555  0.762
2016 Bae C, Anselmi C, Kalia J, Jara-Oseguera A, Schwieters CD, Krepkiy D, Won Lee C, Il Kim J, Faraldo-Gómez JD, Swartz KJ. Structure of a Double-Knot Tarantula Toxin Bound to the TRPV1 Channel at the Protein-Lipid Interface Biophysical Journal. 110: 285a. DOI: 10.1016/J.Bpj.2015.11.1544  0.874
2016 Jara-Oseguera A, Bae C, Swartz KJ. Extracellular Sodium is Required for Temperature-Dependent Gating in TRPV1 Channels Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1538  0.554
2015 Li M, Toombes GE, Silberberg SD, Swartz KJ. Physical basis of apparent pore dilation of ATP-activated P2X receptor channels. Nature Neuroscience. 18: 1577-83. PMID 26389841 DOI: 10.1038/Nn.4120  0.795
2015 Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Vladimir YY, Kim JI, Swartz KJ. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 4: e06774. PMID 25948544 DOI: 10.7554/Elife.06774  0.841
2015 Hanson SM, Newstead S, Swartz KJ, Sansom MS. Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. Biophysical Journal. 108: 1425-34. PMID 25809255 DOI: 10.1016/J.Bpj.2015.02.013  0.481
2015 Bae C, Anselmi C, Kalia J, Jara-Oseguera A, Schwieters CD, Krepkiy D, Lee CW, Kim E, Kim JI, Faraldo-Gómez JD, Swartz KJ. Author response: Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin Elife. DOI: 10.7554/Elife.11273.028  0.854
2015 Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Author response: Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels Elife. DOI: 10.7554/Elife.06774.017  0.839
2015 Jara-Oseguera A, Swartz KJ. Unraveling Allosteric Coupling Mechanisms in the TRPV1 Channel Biophysical Journal. 108: 124a. DOI: 10.1016/J.Bpj.2014.11.695  0.608
2015 Babikow E, Papp F, Lomash S, Smith J, Swartz K. Investigating the Function of a Novel Voltage-Sensing Protein Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2328  0.486
2015 Bae C, Jara-Oseguera A, Krepkiy DV, Ryu J, Kim JI, Swartz KJ. Surface Characterization and Membrane Interaction of Double-Knot Toxin, an Activator of TRPV1 Channels Biophysical Journal. 108: 36a. DOI: 10.1016/J.Bpj.2014.11.227  0.85
2015 Toombes GE, Li M, Silberberg SD, Swartz KJ. Ion Accumulation and Depletion in Patch Clamp Experiments Biophysical Journal. 108: 289a. DOI: 10.1016/J.Bpj.2014.11.1576  0.742
2015 Li M, Toombes G, Silberberg SD, Swartz KJ. Rapid Activation of Distinct Conducting States in P2X Receptor Channels Biophysical Journal. 108: 193a. DOI: 10.1016/J.Bpj.2014.11.1065  0.784
2014 Mihailescu M, Krepkiy D, Milescu M, Gawrisch K, Swartz KJ, White S. Structural interactions of a voltage sensor toxin with lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. 111: E5463-70. PMID 25453087 DOI: 10.1073/Pnas.1415324111  0.841
2014 Toombes GE, Swartz KJ. Divining the design principles of voltage sensors. The Journal of General Physiology. 143: 139-44. PMID 24470485 DOI: 10.1085/Jgp.201411162  0.419
2014 Li M, Harnish E, Silberberg SD, Swartz KJ. Subtype-Specific Control of P2X Receptor Signaling by ATP and Magnesium Biophysical Journal. 106: 153a. DOI: 10.1016/J.Bpj.2013.11.881  0.779
2014 Bae C, Krepkiy DV, Kalia J, Kim J, Kim JI, Swartz KJ. Structural Characterization of Double-Knot Toxin, an Activator of TRPV1 Channels Biophysical Journal. 106: 757a. DOI: 10.1016/J.Bpj.2013.11.4165  0.858
2014 Hanson SM, Newstead S, Swartz KJ, Sansom MSP. Toward the Mechanism of Capsaicin Binding to TRPV1 in a Lipid Bilayer via Atomistic Simulation Biophysical Journal. 106: 756. DOI: 10.1016/J.Bpj.2013.11.4159  0.455
2014 Jara-Oseguera A, Bae C, Zhang F, Chang T, Kim JI, Swartz KJ. Exploring the Architecture of the Outer Pore of the TRPV1 Channel with Double-Knot Toxin Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4157  0.689
2014 Papp F, Babikow E, Smith J, Chang T, Swartz KJ. Exploring Conformational Rearrangements in a Novel Voltage-Sensing Protein Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4102  0.443
2014 Zamanian M, Bae C, Tilley D, Gupta K, Sack J, Yarov-Yarovoy V, Kim JI, Swartz K. Common Interaction Surfaces for Tarantula Toxins Targeting Kv and ASIC Channels Biophysical Journal. 106: 737-738. DOI: 10.1016/J.Bpj.2013.11.4065  0.618
2014 Zhang F, Krepkiy D, Bae C, Moiseenkova-Bell V, Hanson S, Gorshkova I, Pearce L, Blumberg PM, Kim JI, Swartz KJ. Lipid-Mediated Interaction of Double-Knot Toxin with TRPV1 Channels Biophysical Journal. 106: 336a. DOI: 10.1016/J.Bpj.2013.11.1923  0.841
2013 Heymann G, Dai J, Li M, Silberberg SD, Zhou HX, Swartz KJ. Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels. Proceedings of the National Academy of Sciences of the United States of America. 110: E4045-54. PMID 24082111 DOI: 10.1073/Pnas.1311071110  0.839
2013 Li M, Silberberg SD, Swartz KJ. Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+. Proceedings of the National Academy of Sciences of the United States of America. 110: E3455-63. PMID 23959888 DOI: 10.1073/Pnas.1308088110  0.78
2013 Swartz KJ. The scorpion toxin and the potassium channel. Elife. 2: e00873. PMID 23705072 DOI: 10.7554/Elife.00873  0.556
2013 Kalia J, Swartz KJ. The design principle of paddle motifs in voltage sensors. Nature Structural & Molecular Biology. 20: 534-5. PMID 23649359 DOI: 10.1038/Nsmb.2578  0.808
2013 Kalia J, Swartz KJ. Exploring structure-function relationships between TRP and Kv channels. Scientific Reports. 3: 1523. PMID 23519328 DOI: 10.1038/Srep01523  0.837
2013 Milescu M, Lee HC, Bae CH, Kim JI, Swartz KJ. Opening the shaker K+ channel with hanatoxin. The Journal of General Physiology. 141: 203-16. PMID 23359283 DOI: 10.1085/Jgp.201210914  0.861
2013 Kalia J, Swartz KJ. Common principles of voltage-dependent gating for Hv and Kv channels. Neuron. 77: 214-6. PMID 23352157 DOI: 10.1016/J.Neuron.2013.01.001  0.796
2013 Milescu M, Lee H, Bae CH, Kim JI, Swartz K. Opening the Shaker Kv Channel with Hanatoxin Biophysical Journal. 104: 1-4. DOI: 10.1016/J.Bpj.2012.11.713  0.858
2013 Zamanian M, Bae CH, Kim JI, Swartz K. Defining the Interactive Surfaces of Tarantula Toxins for Voltage Sensors in Kv Channels Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.712  0.635
2013 Heymann G, Li M, Silberberg SD, Swartz KJ. Engineering Metal Bridges to Constrain the Structure of the Open State of P2X Receptors Biophysical Journal. 104: 63a. DOI: 10.1016/J.Bpj.2012.11.385  0.826
2013 Kalia J, Bae C, Il Kim J, Swartz KJ. Functional Characterization of the Double Knot Toxin (DkTx) as an Activator of the TRPV1 Ion Channel Biophysical Journal. 104: 456a. DOI: 10.1016/J.Bpj.2012.11.2524  0.793
2013 Hanson SM, Swartz KJ, Newstead S, Sansom MS. Molecular Dynamics Studies of Lipophilic Small Molecule TRPV1 Ligands in Lipid Bilayers Biophysical Journal. 104: 456a. DOI: 10.1016/J.Bpj.2012.11.2523  0.543
2012 Bae C, Kalia J, Song I, Yu J, Kim HH, Swartz KJ, Kim JI. High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels. Plos One. 7: e51516. PMID 23240036 DOI: 10.1371/Journal.Pone.0051516  0.732
2012 Krepkiy D, Gawrisch K, Swartz KJ. Structural interactions between lipids, water and S1-S4 voltage-sensing domains. Journal of Molecular Biology. 423: 632-47. PMID 22858867 DOI: 10.1016/J.Jmb.2012.07.015  0.797
2012 Lee CW, Bae C, Lee J, Ryu JH, Kim HH, Kohno T, Swartz KJ, Kim JI. Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca(2+) channels. Biochemistry. 51: 1862-73. PMID 22329781 DOI: 10.1021/Bi201633J  0.499
2012 Krepkiy D, Gawrisch K, Swartz KJ. Protein- Lipid Interactions in Lipid Reconstituted Potassium Channel Voltage-Sensing Domains Biophysical Journal. 102: 685a. DOI: 10.1016/J.Bpj.2011.11.3722  0.807
2012 Kalia J, Swartz KJ. Mechanism of Inhibition of Voltage-Gated Potassium Channels by Guanidine Compounds Biophysical Journal. 102: 533a. DOI: 10.1016/J.Bpj.2011.11.2913  0.815
2012 Ladt KC, Bae C, Yu J, Kim JI, Swartz K. Activation of TRPV1 by a Recombinant Double-Knot Toxin from a Chinese Bird Spider Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1872  0.599
2012 Li M, Silberberg SD, Swartz KJ. Subtype Specific Activation of P2X Receptors by Free and Magnesium-Bound ATP Biophysical Journal. 102: 336a-337a. DOI: 10.1016/J.Bpj.2011.11.1845  0.732
2012 Bosmans F, Swartz KJ. Sodium Channel Voltage Sensor Movements Are Influenced by the Auxiliary β1 Subunit Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1789  0.715
2011 Bosmans F, Milescu M, Swartz KJ. Palmitoylation influences the function and pharmacology of sodium channels. Proceedings of the National Academy of Sciences of the United States of America. 108: 20213-8. PMID 22123950 DOI: 10.1073/Pnas.1108497108  0.83
2011 Lee CW, Eu YJ, Min HJ, Cho EM, Lee JH, Kim HH, Nah SY, Swartz KJ, Kim JI. Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels. Biochemical and Biophysical Research Communications. 416: 277-82. PMID 22093820 DOI: 10.1016/J.Bbrc.2011.11.003  0.487
2011 Kalia J, Swartz KJ. Elucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels. Molecular Pharmacology. 80: 1085-95. PMID 21926190 DOI: 10.1124/Mol.111.074989  0.809
2011 Bosmans F, Puopolo M, Martin-Eauclaire MF, Bean BP, Swartz KJ. Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors. The Journal of General Physiology. 138: 59-72. PMID 21670206 DOI: 10.1085/Jgp.201110614  0.872
2011 Kawate T, Robertson JL, Li M, Silberberg SD, Swartz KJ. Ion access pathway to the transmembrane pore in P2X receptor channels. The Journal of General Physiology. 137: 579-90. PMID 21624948 DOI: 10.1085/Jgp.201010593  0.764
2011 Kawate T, Robertson JL, Li M, Silberberg SD, Swartz KJ. Ion Access Pathway to the Transmembrane Pore in P2X Receptors Biophysical Journal. 100: 25a. DOI: 10.1016/J.Bpj.2010.12.341  0.724
2011 Bosmans F, Milescu M, Swartz KJ. Palmitoylation Affects the Interaction of Animal Toxins with Sodium Channels Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2497  0.88
2011 Krepkiy D, Hanson S, Gawrisch K, Swartz KJ. Conformational Changes in Lipid Reconstituted Potassium Channel Voltage-Sensing Domains Biophysical Journal. 100: 282a. DOI: 10.1016/J.Bpj.2010.12.1748  0.789
2011 Li M, Silberberg SD, Swartz KJ. Atp4- Activates P2x Receptors Biophysical Journal. 100: 270a. DOI: 10.1016/J.Bpj.2010.12.1684  0.738
2010 Phillips LR, Swartz KJ. Position and motions of the S4 helix during opening of the Shaker potassium channel. The Journal of General Physiology. 136: 629-44. PMID 21115696 DOI: 10.1085/Jgp.201010517  0.556
2010 Li M, Kawate T, Silberberg SD, Swartz KJ. Pore-opening mechanism in trimeric P2X receptor channels. Nature Communications. 1: 44. PMID 20975702 DOI: 10.1038/Ncomms1048  0.828
2010 Jung HH, Jung HJ, Milescu M, Lee CW, Lee S, Lee JY, Eu YJ, Kim HH, Swartz KJ, Kim JI. Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophysical Journal. 99: 638-46. PMID 20643084 DOI: 10.1016/J.Bpj.2010.04.061  0.8
2010 Lee S, Milescu M, Jung HH, Lee JY, Bae CH, Lee CW, Kim HH, Swartz KJ, Kim JI. Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels . Biochemistry. 49: 5134-42. PMID 20509680 DOI: 10.1021/Bi100246U  0.849
2010 Bosmans F, Swartz KJ. Targeting voltage sensors in sodium channels with spider toxins. Trends in Pharmacological Sciences. 31: 175-82. PMID 20097434 DOI: 10.1016/J.Tips.2009.12.007  0.797
2010 Bosmans F, Puopolo M, Martin-Eauclaire M, Bean BP, Swartz KJ. Defining the Voltage Sensor Properties and Pharmacology of Nav1.9 Biophysical Journal. 98: 115a. DOI: 10.1016/J.Bpj.2009.12.4215  0.848
2010 Kawate T, Li M, Silberberg SD, Swartz KJ. Identifying the Ion Access Pathway to the Transmembrane Pore in P2X Receptors Biophysical Journal. 98: 702a. DOI: 10.1016/J.Bpj.2009.12.3852  0.765
2010 Li M, Kawate T, Silberberg SD, Swartz KJ. Structure Rearrangement of the Pore in P2X Receptors During Gating Biophysical Journal. 98: 610a. DOI: 10.1016/J.Bpj.2009.12.3328  0.801
2010 Kalia J, Swartz KJ. Exploring Structural Relationships between TRP and Kv Channels Biophysical Journal. 98: 341a. DOI: 10.1016/J.Bpj.2009.12.1847  0.837
2010 Krepkiy D, Swartz KJ. Conformational Changes in Potassium Channel Voltage-Sensing Domains Reconstituted into Different Lipids Biophysical Journal. 98: 315a. DOI: 10.1016/J.Bpj.2009.12.1711  0.806
2009 Krepkiy D, Mihailescu M, Freites JA, Schow EV, Worcester DL, Gawrisch K, Tobias DJ, White SH, Swartz KJ. Structure and hydration of membranes embedded with voltage-sensing domains. Nature. 462: 473-9. PMID 19940918 DOI: 10.1038/Nature08542  0.803
2009 Milescu M, Bosmans F, Lee S, Alabi AA, Kim JI, Swartz KJ. Interactions between lipids and voltage sensor paddles detected with tarantula toxins. Nature Structural & Molecular Biology. 16: 1080-5. PMID 19783984 DOI: 10.1038/Nsmb.1679  0.852
2009 Silberberg SD, Swartz KJ. Structural biology: Trimeric ion-channel design. Nature. 460: 580-1. PMID 19641581 DOI: 10.1038/460580A  0.599
2009 Bosmans F, Martin-Eauclaire M, Swartz KJ. Using Potassium Channels As Reporters To Deconstruct The Function And Pharmacology Of Sodium Channel Voltage Sensors Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.961  0.811
2009 Milescu M, Swartz KJ. Voltage-sensor Pharmacology Of Voltage-activated Calcium Channels (cav) Biophysical Journal. 96: 184a. DOI: 10.1016/J.Bpj.2008.12.862  0.841
2009 Li M, Silberberg SD, Swartz KJ. Accessibility of Ag+ in the Pore of P2X Receptor Channels Biophysical Journal. 96: 485a. DOI: 10.1016/J.Bpj.2008.12.2503  0.81
2009 Krepkiy D, Mihailescu E, Gawrisch K, White SH, Swartz KJ. Water-filled Cavities in the Voltage-Sensing Domain of a Potassium Channel Embedded in Lipid Bilayers Biophysical Journal. 96: 483a-484a. DOI: 10.1016/J.Bpj.2008.12.2494  0.772
2008 Swartz KJ. Sensing voltage across lipid membranes. Nature. 456: 891-7. PMID 19092925 DOI: 10.1038/Nature07620  0.547
2008 Bosmans F, Martin-Eauclaire MF, Swartz KJ. Deconstructing voltage sensor function and pharmacology in sodium channels. Nature. 456: 202-8. PMID 19005548 DOI: 10.1038/Nature07473  0.785
2008 Li M, Chang TH, Silberberg SD, Swartz KJ. Gating the pore of P2X receptor channels. Nature Neuroscience. 11: 883-7. PMID 18587390 DOI: 10.1038/Nn.2151  0.814
2007 Alabi AA, Bahamonde MI, Jung HJ, Kim JI, Swartz KJ. Portability of paddle motif function and pharmacology in voltage sensors. Nature. 450: 370-5. PMID 18004375 DOI: 10.1038/Nature06266  0.854
2007 Milescu M, Vobecky J, Roh SH, Kim SH, Jung HJ, Kim JI, Swartz KJ. Tarantula toxins interact with voltage sensors within lipid membranes. The Journal of General Physiology. 130: 497-511. PMID 17938232 DOI: 10.1085/Jgp.200709869  0.827
2007 Silberberg SD, Li M, Swartz KJ. Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels. Neuron. 54: 263-74. PMID 17442247 DOI: 10.1016/J.Neuron.2007.03.020  0.804
2007 Swartz KJ. Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon : Official Journal of the International Society On Toxinology. 49: 213-30. PMID 17097703 DOI: 10.1016/J.Toxicon.2006.09.024  0.685
2006 Soler-Llavina GJ, Chang TH, Swartz KJ. Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel. Neuron. 52: 623-34. PMID 17114047 DOI: 10.1016/J.Neuron.2006.10.005  0.861
2006 Swartz KJ. Greasing the gears of potassium channels. Nature Chemical Biology. 2: 401-2. PMID 16850015 DOI: 10.1038/Nchembio0806-401  0.656
2005 Kitaguchi T, Swartz KJ. An inhibitor of TRPV1 channels isolated from funnel Web spider venom. Biochemistry. 44: 15544-9. PMID 16300403 DOI: 10.1021/Bi051494L  0.808
2005 Swartz KJ. Structure and anticipatory movements of the S6 gate in Kv channels. The Journal of General Physiology. 126: 413-7. PMID 16260835 DOI: 10.1085/Jgp.200509430  0.573
2005 Phillips LR, Milescu M, Li-Smerin Y, Mindell JA, Kim JI, Swartz KJ. Voltage-sensor activation with a tarantula toxin as cargo. Nature. 436: 857-60. PMID 16094370 DOI: 10.1038/Nature03873  0.844
2005 Jung HJ, Lee JY, Kim SH, Eu YJ, Shin SY, Milescu M, Swartz KJ, Kim JI. Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel. Biochemistry. 44: 6015-23. PMID 15835890 DOI: 10.1021/Bi0477034  0.838
2005 Silberberg SD, Chang TH, Swartz KJ. Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels. The Journal of General Physiology. 125: 347-59. PMID 15795310 DOI: 10.1085/Jgp.200409221  0.58
2004 Swartz KJ. Towards a structural view of gating in potassium channels. Nature Reviews. Neuroscience. 5: 905-16. PMID 15550946 DOI: 10.1038/Nrn1559  0.633
2004 Kitaguchi T, Sukhareva M, Swartz KJ. Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal. The Journal of General Physiology. 124: 319-32. PMID 15365093 DOI: 10.1085/Jgp.200409098  0.867
2004 Swartz KJ. Opening the gate in potassium channels. Nature Structural & Molecular Biology. 11: 499-501. PMID 15164005 DOI: 10.1038/Nsmb0604-499  0.627
2004 Wang JM, Roh SH, Kim S, Lee CW, Kim JI, Swartz KJ. Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. The Journal of General Physiology. 123: 455-67. PMID 15051809 DOI: 10.1085/Jgp.200309005  0.579
2004 Lee CW, Kim S, Roh SH, Endoh H, Kodera Y, Maeda T, Kohno T, Wang JM, Swartz KJ, Kim JI. Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating. Biochemistry. 43: 890-7. PMID 14744131 DOI: 10.1021/Bi0353373  0.596
2003 Lee HC, Wang JM, Swartz KJ. Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels. Neuron. 40: 527-36. PMID 14642277 DOI: 10.1016/S0896-6273(03)00636-6  0.647
2003 Sukhareva M, Hackos DH, Swartz KJ. Constitutive activation of the Shaker Kv channel. The Journal of General Physiology. 122: 541-56. PMID 14557403 DOI: 10.1085/Jgp.200308905  0.879
2003 Soler-Llavina GJ, Holmgren M, Swartz KJ. Defining the conductance of the closed state in a voltage-gated K+ channel. Neuron. 38: 61-7. PMID 12691664 DOI: 10.1016/S0896-6273(03)00157-0  0.849
2002 Takeuchi K, Park E, Lee C, Kim J, Takahashi H, Swartz K, Shimada I. Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel. Journal of Molecular Biology. 321: 517-26. PMID 12162963 DOI: 10.1016/S0022-2836(02)00595-8  0.585
2002 Hackos DH, Chang TH, Swartz KJ. Scanning the intracellular S6 activation gate in the shaker K+ channel. The Journal of General Physiology. 119: 521-32. PMID 12034760 DOI: 10.1085/Jgp.20028569  0.817
2001 Li-Smerin Y, Swartz KJ. Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. The Journal of General Physiology. 117: 205-18. PMID 11222625 DOI: 10.1085/Jgp.117.3.205  0.874
2000 Winterfield JR, Swartz KJ. A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. The Journal of General Physiology. 116: 637-44. PMID 11055992 DOI: 10.1085/Jgp.116.5.637  0.824
2000 Li-Smerin Y, Swartz KJ. Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel. The Journal of General Physiology. 115: 673-84. PMID 10828242 DOI: 10.1085/Jgp.115.6.673  0.872
2000 Takahashi H, Kim JI, Min HJ, Sato K, Swartz KJ, Shimada I. Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins. Journal of Molecular Biology. 297: 771-80. PMID 10731427 DOI: 10.1006/Jmbi.2000.3609  0.615
2000 Li-Smerin Y, Hackos DH, Swartz KJ. A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel. Neuron. 25: 411-23. PMID 10719895 DOI: 10.1016/S0896-6273(00)80904-6  0.85
2000 Li-Smerin Y, Hackos DH, Swartz KJ. alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. The Journal of General Physiology. 115: 33-50. PMID 10613917 DOI: 10.1085/Jgp.115.1.33  0.826
1998 Chuang RS, Jaffe H, Cribbs L, Perez-Reyes E, Swartz KJ. Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. Nature Neuroscience. 1: 668-74. PMID 10196582 DOI: 10.1038/3669  0.501
1998 Li-Smerin Y, Swartz KJ. Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 95: 8585-9. PMID 9671721 DOI: 10.1073/Pnas.95.15.8585  0.874
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