Simon Z Giroux - Publications

Affiliations: 
Vertex Pharmaceuticals, Boston, MA, United States 

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wilson JC, Boyd MJ, Giroux S, Bandarage UK. Application of a Dual Catalytic Nickel/Iridium-Based Photoredox Reaction to Synthesize 2-Alkyl--Arylindoles in a Continuous Flow. The Journal of Organic Chemistry. PMID 32915566 DOI: 10.1021/Acs.Joc.0C01809  0.366
2019 Gair JJ, Grey RL, Giroux S, Brodney MA. Palladium Catalyzed Hydrodefluorination of Fluoro-(hetero)arenes Organic Letters. 21: 2482-2487. PMID 30912952 DOI: 10.1021/Acs.Orglett.9B00889  0.328
2018 Bissonnette NB, Boyd MJ, May GD, Giroux S, Nuhant P. C-H Functionalization of Heteroarenes Using Unactivated Alkyl Halides through Visible-Light Photoredox Catalysis under Basic Conditions. The Journal of Organic Chemistry. PMID 30092130 DOI: 10.1021/Acs.Joc.8B01589  0.374
2015 Giroux S, Bilimoria D, Cadilhac C, Cottrell KM, Denis F, Dietrich E, Ewing N, Henderson JA, L'Heureux L, Mani N, Morris M, Nicolas O, Reddy TJ, Selliah S, Shawgo RS, et al. Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers. Bioorganic & Medicinal Chemistry Letters. 25: 936-9. PMID 25595681 DOI: 10.1016/J.Bmcl.2014.12.046  0.337
2015 Henderson JA, Bilimoria D, Bubenik M, Cadilhac C, Cottrell KM, Dietrich E, Denis F, Ewing N, Falardeau G, Giroux S, Grey R, L'Heureux L, Liu B, Mani N, Morris M, et al. Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency. Bioorganic & Medicinal Chemistry Letters. 25: 944-7. PMID 25577041 DOI: 10.1016/J.Bmcl.2014.12.045  0.313
2015 Henderson JA, Bilimoria D, Bubenik M, Cadilhac C, Cottrell KM, Denis F, Dietrich E, Ewing N, Falardeau G, Giroux S, L'Heureux L, Liu B, Mani N, Morris M, Nicolas O, et al. Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores. Bioorganic & Medicinal Chemistry Letters. 25: 948-51. PMID 25577039 DOI: 10.1016/J.Bmcl.2014.12.042  0.337
2014 Giroux S, Xu J, Reddy TJ, Morris M, Cottrell KM, Cadilhac C, Henderson JA, Nicolas O, Bilimoria D, Denis F, Mani N, Ewing N, Shawgo R, L'Heureux L, Selliah S, et al. Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors. Acs Medicinal Chemistry Letters. 5: 240-3. PMID 24900811 DOI: 10.1021/Ml300461F  0.313
2008 Giroux S, Corey EJ. Enantioselective synthesis of a simple benzenoid analogue of glycinoeclepin A. Organic Letters. 10: 5617-9. PMID 19007174 DOI: 10.1021/Ol8024633  0.438
2008 Giroux S, Bethke A, Fielenbach N, Antebi A, Corey EJ. Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A. Organic Letters. 10: 3643-5. PMID 18642835 DOI: 10.1021/Ol801425V  0.405
2008 Giroux S, Corey EJ. An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol. Organic Letters. 10: 801-2. PMID 18247628 DOI: 10.1021/Ol702936F  0.372
2007 Giroux S, Corey EJ. Stereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegans. Journal of the American Chemical Society. 129: 9866-7. PMID 17658816 DOI: 10.1021/Ja074306I  0.389
2006 Hanessian S, Giroux S, Larsson A. Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst. Organic Letters. 8: 5481-4. PMID 17107052 DOI: 10.1021/Ol062167O  0.467
2006 Hanessian S, Chahal N, Giroux S. Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design. The Journal of Organic Chemistry. 71: 7403-11. PMID 16958535 DOI: 10.1021/Jo061098O  0.51
2006 Hanessian S, Giroux S, Mascitti V. The iterative synthesis of acyclic deoxypropionate units and their implication in polyketide-derived natural products Synthesis. 1057-1076. DOI: 10.1055/S-2006-926376  0.462
2005 Hanessian S, Giroux S, Buffat M. Total synthesis and structural confirmation of (+)-longicin. Organic Letters. 7: 3989-92. PMID 16119949 DOI: 10.1021/Ol051483K  0.529
2004 Hanessian S, Mascitti V, Giroux S. Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates. Proceedings of the National Academy of Sciences of the United States of America. 101: 11996-2001. PMID 15210988 DOI: 10.1073/Pnas.0401637101  0.521
2003 Hanessian S, Yang Y, Giroux S, Mascitti V, Ma J, Raeppel F. Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate. Journal of the American Chemical Society. 125: 13784-92. PMID 14599218 DOI: 10.1021/Ja030139K  0.561
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