| Year |
Citation |
Score |
| 2020 |
Hu K, Cai L, Li Z, Glatt H, Shi M, Liu Y. Human CYP2E1-Dependent Mutagenicity of Benzene and Its Hydroxylated Metabolites in V79-derived cells: Suppression and Enhancement by Ethanol Pretreatment. Environmental and Molecular Mutagenesis. PMID 32285472 DOI: 10.1002/Em.22375 |
0.396 |
|
| 2019 |
Chen Y, Wu Y, Xiao W, Jia H, Glatt H, Shi M, Liu Y. Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells. Toxicology. 152329. PMID 31733235 DOI: 10.1016/J.Tox.2019.152329 |
0.414 |
|
| 2019 |
Ebmeyer J, Braeuning A, Glatt H, These A, Hessel-Pras S, Lampen A. Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 130: 79-88. PMID 31103741 DOI: 10.1016/J.Fct.2019.05.019 |
0.42 |
|
| 2019 |
Wiesner-Reinhold M, Barknowitz G, Florian S, Mewis I, Schumacher F, Schreiner M, Glatt H. 1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence. Archives of Toxicology. PMID 30993378 DOI: 10.1007/S00204-019-02452-3 |
0.323 |
|
| 2019 |
Ebmeyer J, Franz L, Lim R, Niemann B, Glatt H, Braeuning A, Lampen A, Hessel-Pras S. Sensitization of Human Liver Cells Towards Fas-Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine. Molecular Nutrition & Food Research. e1801206. PMID 30900802 DOI: 10.1002/Mnfr.201801206 |
0.344 |
|
| 2018 |
Jin G, Cai L, Hu K, Luo Y, Chen Y, Glatt H, Liu Y. Mutagenic activity of N-nitrosodiethylamine in cell lines expressing human CYP2E1 - adequacy of dimethylsulfoxide as solvent. Environmental and Molecular Mutagenesis. PMID 30387191 DOI: 10.1002/Em.22264 |
0.415 |
|
| 2018 |
Li Y, Chen Z, Paonessa JD, Meinl W, Bhattacharya A, Glatt H, Vouros P, Zhang Y. Strong impact of sulfotransferases on DNA adduct formation by 4-aminobiphenyl in bladder and liver in mice. Cancer Medicine. PMID 30306738 DOI: 10.1002/Cam4.1779 |
0.345 |
|
| 2018 |
Monien BH, Sachse B, Meinl W, Abraham K, Lampen A, Glatt H. Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2. Toxicology Letters. PMID 29908303 DOI: 10.1016/J.Toxlet.2018.06.008 |
0.365 |
|
| 2017 |
Tremmel R, Herrmann K, Engst W, Meinl W, Klein K, Glatt H, Zanger UM. Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels. Archives of Toxicology. PMID 28326452 DOI: 10.1007/S00204-017-1955-4 |
0.362 |
|
| 2017 |
Chevereau M, Glatt H, Zalko D, Cravedi JP, Audebert M. Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells. Archives of Toxicology. PMID 28160022 DOI: 10.1007/S00204-017-1935-8 |
0.431 |
|
| 2016 |
Liu Y, Hu K, Jia H, Jin G, Glatt H, Jiang H. Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme. Archives of Toxicology. PMID 27913846 DOI: 10.1007/S00204-016-1904-7 |
0.448 |
|
| 2016 |
Förster N, Mewis I, Glatt H, Haack M, Brigelius-Flohé R, Schreiner M, Ulrichs C. Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food & Function. PMID 27775133 DOI: 10.1039/C6Fo01231K |
0.374 |
|
| 2016 |
Jia H, Zhang C, Glatt H, Liu Y. Role of exposure/recovery schedule in micronuclei induction by several promutagens in V79-derived cells expressing human CYP2E1 and SULT1A1. Mutation Research. Genetic Toxicology and Environmental Mutagenesis. 808: 27-37. PMID 27637483 DOI: 10.1016/J.Mrgentox.2016.08.004 |
0.32 |
|
| 2016 |
Arlt VM, Meinl W, Florian S, Nagy E, Barta F, Thomann M, Mrizova I, Krais AM, Liu M, Richards M, Mirza A, Kopka K, Phillips DH, Glatt H, Stiborova M, et al. Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone. Archives of Toxicology. PMID 27557898 DOI: 10.1007/S00204-016-1808-6 |
0.396 |
|
| 2016 |
Bendadani C, Steinhauser L, Albert K, Glatt H, Monien BH. Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats. Toxicology. PMID 27501763 DOI: 10.1016/J.Tox.2016.08.006 |
0.322 |
|
| 2016 |
Huffman MP, Høie AH, Svendsen C, Brunborg G, Murkovic M, Glatt H, Husøy T. An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol. Mutagenesis. PMID 27226491 DOI: 10.1093/Mutage/Gew025 |
0.416 |
|
| 2016 |
Høie AH, Monien BH, Glatt H, Hjertholm H, Husøy T. DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2. Toxicology Letters. 248: 34-8. PMID 26940682 DOI: 10.1016/J.Toxlet.2016.02.017 |
0.35 |
|
| 2016 |
Glatt H, Sabbioni G, Monien BH, Meinl W. Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of human sulfotransferases in the bioactivation of nitro- and aminotoluenes. Environmental and Molecular Mutagenesis. PMID 26924705 DOI: 10.1002/Em.22005 |
0.396 |
|
| 2016 |
Sachse B, Meinl W, Glatt H, Monien BH. Ethanol and 4-Methylpyrazole Increase DNA Adduct Formation of Furfuryl Alcohol in FVB/N Wild-type Mice and in Mice Expressing Human Sulfotransferases 1A1/1A2. Carcinogenesis. PMID 26775039 DOI: 10.1093/Carcin/Bgw006 |
0.364 |
|
| 2015 |
Zhang C, Lai Y, Jin G, Glatt H, Wei Q, Liu Y. Human CYP2E1-dependent mutagenicity of mono- and dichlorobiphenyls in Chinese hamster (V79)-derived cells. Chemosphere. 144: 1908-1915. PMID 26547025 DOI: 10.1016/J.Chemosphere.2015.10.083 |
0.432 |
|
| 2015 |
Sachse B, Meinl W, Glatt H, Monien BH. Conversion of Suspected Food Carcinogen 5-Hydroxymethylfurfural by Sulfotransferases and Aldehyde Dehydrogenases in Post-Mitochondrial Tissue Preparations of Humans, Mice and Rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26454887 DOI: 10.1093/Toxsci/Kfv228 |
0.347 |
|
| 2015 |
Budnowski J, Hanske L, Schumacher F, Glatt H, Platz S, Rohn S, Blaut M. Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice Journal of Agricultural and Food Chemistry. 63: 8418-8428. PMID 26365197 DOI: 10.1021/Acs.Jafc.5B02948 |
0.324 |
|
| 2015 |
Høie AH, Svendsen C, Brunborg G, Glatt H, Alexander J, Meinl W, Husøy T. Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environmental and Molecular Mutagenesis. 56: 709-14. PMID 26270892 DOI: 10.1002/Em.21963 |
0.367 |
|
| 2015 |
Høie AH, Monien BH, Sakhi AK, Glatt H, Hjertholm H, Husøy T. Formation of DNA adducts in wild-type and transgenic mice expressing human sulfotransferases 1A1 and 1A2 after oral exposure to furfuryl alcohol. Mutagenesis. PMID 25904584 DOI: 10.1093/Mutage/Gev023 |
0.391 |
|
| 2015 |
Ehlers A, Florian S, Schumacher F, Meinl W, Lenze D, Hummel M, Heise T, Seidel A, Glatt H, Lampen A. The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens. Molecular Nutrition & Food Research. 59: 685-97. PMID 25559983 DOI: 10.1002/Mnfr.201400707 |
0.422 |
|
| 2014 |
Sachse B, Meinl W, Sommer Y, Glatt H, Seidel A, Monien BH. Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study. Archives of Toxicology. PMID 25370010 DOI: 10.1007/S00204-014-1392-6 |
0.379 |
|
| 2014 |
Sachse B, Meinl W, Glatt H, Monien BH. The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models. Carcinogenesis. 35: 2339-45. PMID 25053625 DOI: 10.1093/Carcin/Bgu152 |
0.375 |
|
| 2014 |
Bendadani C, Meinl W, Monien B, Dobbernack G, Florian S, Engst W, Nolden T, Himmelbauer H, Glatt H. Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models Chemical Research in Toxicology. 27: 1060-1069. PMID 24802129 DOI: 10.1021/Tx500129G |
0.429 |
|
| 2014 |
Wiesner M, Schreiner M, Glatt H. High mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 67: 10-6. PMID 24530313 DOI: 10.1016/J.Fct.2014.02.008 |
0.339 |
|
| 2014 |
Barknowitz G, Engst W, Schmidt S, Bernau M, Monien BH, Kramer M, Florian S, Glatt H. Identification and quantification of protein adducts formed by metabolites of 1-methoxy-3-indolylmethyl glucosinolate in vitro and in mouse models. Chemical Research in Toxicology. 27: 188-99. PMID 24422435 DOI: 10.1021/Tx400277W |
0.384 |
|
| 2014 |
Bendadani C, Meinl W, Monien BH, Dobbernack G, Glatt H. The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester. Archives of Toxicology. 88: 815-21. PMID 24337722 DOI: 10.1007/S00204-013-1182-6 |
0.417 |
|
| 2014 |
Herrmann K, Engst W, Meinl W, Florian S, Cartus AT, Schrenk D, Appel KE, Nolden T, Himmelbauer H, Glatt H. Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2. Carcinogenesis. 35: 935-41. PMID 24318996 DOI: 10.1093/Carcin/Bgt408 |
0.405 |
|
| 2014 |
Schumacher F, Florian S, Schnapper A, Monien BH, Mewis I, Schreiner M, Seidel A, Engst W, Glatt H. A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells. Archives of Toxicology. 88: 823-36. PMID 24154822 DOI: 10.1007/S00204-013-1149-7 |
0.419 |
|
| 2014 |
Glatt H, Pietsch KE, Sturla SJ, Meinl W. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Archives of Toxicology. 88: 161-9. PMID 23881331 DOI: 10.1007/S00204-013-1097-2 |
0.42 |
|
| 2014 |
Sæther AH, Monien B, Glatt H, Hjertholm H, Svendsen C, Alexander J, Husøy T. Formation of DNA adducts in wt and transgenic mice expressing human sulfotransferases after treatment with heterocyclic amines and furans Toxicology Letters. 229: S183. DOI: 10.1016/J.Toxlet.2014.06.624 |
0.337 |
|
| 2013 |
Meinl W, Tsoi C, Swedmark S, Tibbs ZE, Falany CN, Glatt H. Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium. Mutagenesis. 28: 609-19. PMID 23894158 DOI: 10.1093/Mutage/Get039 |
0.419 |
|
| 2013 |
Herrmann K, Schumacher F, Engst W, Appel KE, Klein K, Zanger UM, Glatt H. Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human: Liver samples Carcinogenesis. 34: 1025-1030. PMID 23334163 DOI: 10.1093/Carcin/Bgt013 |
0.363 |
|
| 2013 |
Schumacher F, Herrmann K, Florian S, Engst W, Glatt H. Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol. Analytical Biochemistry. 434: 4-11. PMID 23142629 DOI: 10.1016/J.Ab.2012.11.001 |
0.343 |
|
| 2012 |
Kollock R, Glatt H. Opposing--activating or inhibitory--effects of cimetidine and daidzein on human ADH1C activity depending on substrates and solvents. Drug Metabolism Letters. 6: 258-64. PMID 23506554 DOI: 10.2174/1872312811206040005 |
0.334 |
|
| 2012 |
Schumacher F, Engst W, Monien BH, Florian S, Schnapper A, Steinhauser L, Albert K, Frank H, Seidel A, Glatt H. Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS. Analytical Chemistry. 84: 6256-62. PMID 22816785 DOI: 10.1021/Ac301436Q |
0.399 |
|
| 2012 |
Cartus AT, Herrmann K, Weishaupt LW, Merz KH, Engst W, Glatt H, Schrenk D. Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 129: 21-34. PMID 22610610 DOI: 10.1093/Toxsci/Kfs181 |
0.396 |
|
| 2012 |
Monien BH, Engst W, Barknowitz G, Seidel A, Glatt H. Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed. Chemical Research in Toxicology. 25: 1484-92. PMID 22563731 DOI: 10.1021/Tx300150N |
0.367 |
|
| 2012 |
Florian S, Bauer-Marinovic M, Taugner F, Dobbernack G, Monien BH, Meinl W, Glatt H. Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2. Molecular Nutrition & Food Research. 56: 593-600. PMID 22351042 DOI: 10.1002/Mnfr.201100574 |
0.332 |
|
| 2012 |
Bauer-Marinovic M, Taugner F, Florian S, Glatt H. Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2. Archives of Toxicology. 86: 701-11. PMID 22349055 DOI: 10.1007/S00204-012-0807-5 |
0.352 |
|
| 2012 |
Herrmann K, Engst W, Appel KE, Monien BH, Glatt H. Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods. Mutagenesis. 27: 453-62. PMID 22337896 DOI: 10.1093/Mutage/Ges004 |
0.455 |
|
| 2012 |
Svendsen C, Meinl W, Glatt H, Alexander J, Knutsen HK, Hjertholm H, Rasmussen T, Husøy T. Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases. Molecular Carcinogenesis. 51: 984-92. PMID 22006426 DOI: 10.1002/Mc.20869 |
0.358 |
|
| 2012 |
Glatt H, Schneider H, Murkovic M, Monien BH, Meinl W. Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases. Mutagenesis. 27: 41-8. PMID 21825114 DOI: 10.1093/Mutage/Ger054 |
0.407 |
|
| 2011 |
Dobbernack G, Meinl W, Schade N, Florian S, Wend K, Voigt I, Himmelbauer H, Gross M, Liehr T, Glatt H. Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2. Carcinogenesis. 32: 1734-40. PMID 21900212 DOI: 10.1093/Carcin/Bgr204 |
0.377 |
|
| 2011 |
Monien BH, Herrmann K, Florian S, Glatt H. Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice. Carcinogenesis. 32: 1533-9. PMID 21729924 DOI: 10.1093/Carcin/Bgr126 |
0.36 |
|
| 2011 |
Menozzi-Smarrito C, Wong CC, Meinl W, Glatt H, Fumeaux R, Munari C, Robert F, Williamson G, Barron D. First chemical synthesis and in vitro characterization of the potential human metabolites 5-o-feruloylquinic acid 4'-sulfate and 4'-O-glucuronide. Journal of Agricultural and Food Chemistry. 59: 5671-6. PMID 21417257 DOI: 10.1021/Jf200272M |
0.317 |
|
| 2011 |
Baasanjav-Gerber C, Monien BH, Mewis I, Schreiner M, Barillari J, Iori R, Glatt H. Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase. Molecular Nutrition & Food Research. 55: 783-92. PMID 21213326 DOI: 10.1002/Mnfr.201000352 |
0.386 |
|
| 2011 |
Baasanjav-Gerber C, Hollnagel HM, Brauchmann J, Iori R, Glatt H. Detection of genotoxicants in Brassicales using endogenous DNA as a surrogate target and adducts determined by 32P-postlabelling as an experimental end point. Mutagenesis. 26: 407-13. PMID 21193518 DOI: 10.1093/Mutage/Geq108 |
0.312 |
|
| 2011 |
Glatt H, Baasanjav-Gerber C, Schumacher F, Monien BH, Schreiner M, Frank H, Seidel A, Engst W. 1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation. Chemico-Biological Interactions. 192: 81-6. PMID 20846518 DOI: 10.1016/J.Cbi.2010.09.009 |
0.375 |
|
| 2010 |
Haack M, Löwinger M, Lippmann D, Kipp A, Pagnotta E, Iori R, Monien BH, Glatt H, Brauer MN, Wessjohann LA, Brigelius-Flohé R. Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. Biological Chemistry. 391: 1281-93. PMID 20868228 DOI: 10.1515/Bc.2010.134 |
0.358 |
|
| 2010 |
Thierbach R, Drewes G, Fusser M, Voigt A, Kuhlow D, Blume U, Schulz TJ, Reiche C, Glatt H, Epe B, Steinberg P, Ristow M. The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals. The Biochemical Journal. 432: 165-72. PMID 20819074 DOI: 10.1042/Bj20101116 |
0.356 |
|
| 2010 |
Platt KL, Edenharder R, Aderhold S, Muckel E, Glatt H. Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 703: 90-98. PMID 20713174 DOI: 10.1016/J.Mrgentox.2010.08.007 |
0.395 |
|
| 2010 |
Martin FL, Patel II, Sozeri O, Singh PB, Ragavan N, Nicholson CM, Frei E, Meinl W, Glatt H, Phillips DH, Arlt VM. Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro-carcinogens to DNA-damaging metabolites. The Prostate. 70: 1586-99. PMID 20687231 DOI: 10.1002/Pros.21194 |
0.383 |
|
| 2010 |
Brand W, Boersma MG, Bik H, Hoek-van den Hil EF, Vervoort J, Barron D, Meinl W, Glatt H, Williamson G, van Bladeren PJ, Rietjens IM. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 617-25. PMID 20056724 DOI: 10.1124/Dmd.109.031047 |
0.363 |
|
| 2010 |
Stjernschantz E, Reinen J, Meinl W, George BJ, Glatt H, Vermeulen NP, Oostenbrink C. Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition. Molecular and Cellular Endocrinology. 317: 127-40. PMID 20025931 DOI: 10.1016/J.Mce.2009.12.001 |
0.333 |
|
| 2010 |
Liu Y, Glatt H. Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis. Environmental and Molecular Mutagenesis. 51: 23-30. PMID 19484729 DOI: 10.1002/Em.20503 |
0.435 |
|
| 2009 |
Kollock R, Rost K, Batke M, Glatt H. Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases. Toxicology Letters. 191: 360-4. PMID 19822198 DOI: 10.1016/J.Toxlet.2009.10.003 |
0.311 |
|
| 2009 |
Bakhiya N, Arlt VM, Bahn A, Burckhardt G, Phillips DH, Glatt H. Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology. 264: 74-9. PMID 19643159 DOI: 10.1016/J.Tox.2009.07.014 |
0.351 |
|
| 2009 |
Monien BH, Müller C, Bakhiya N, Donath C, Frank H, Seidel A, Glatt H. Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats. Toxicology. 262: 80-5. PMID 19481134 DOI: 10.1016/J.Tox.2009.05.016 |
0.359 |
|
| 2009 |
Bakhiya N, Monien B, Frank H, Seidel A, Glatt H. Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural Biochemical Pharmacology. 78: 414-419. PMID 19394312 DOI: 10.1016/J.Bcp.2009.04.017 |
0.375 |
|
| 2009 |
Monien BH, Frank H, Seidel A, Glatt H. Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo. Chemical Research in Toxicology. 22: 1123-8. PMID 19382817 DOI: 10.1021/Tx9000623 |
0.342 |
|
| 2009 |
Meinl W, Sczesny S, Brigelius-Flohé R, Blaut M, Glatt H. Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1179-86. PMID 19282396 DOI: 10.1124/Dmd.108.025916 |
0.361 |
|
| 2009 |
Wincent E, Amini N, Luecke S, Glatt H, Bergman J, Crescenzi C, Rannug A, Rannug U. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. The Journal of Biological Chemistry. 284: 2690-6. PMID 19054769 DOI: 10.1074/Jbc.M808321200 |
0.328 |
|
| 2008 |
Monien BH, Müller C, Engst W, Frank H, Seidel A, Glatt H. Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling. Chemical Research in Toxicology. 21: 2017-25. PMID 18788758 DOI: 10.1021/Tx800217D |
0.307 |
|
| 2008 |
Glatt H, Rost K, Frank H, Seidel A, Kollock R. Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1. Archives of Biochemistry and Biophysics. 477: 196-205. PMID 18621017 DOI: 10.1016/J.Abb.2008.06.020 |
0.336 |
|
| 2008 |
Liu Y, Glatt H. Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutation Research. 643: 64-9. PMID 18616954 DOI: 10.1016/J.Mrfmmm.2008.06.003 |
0.429 |
|
| 2008 |
Hoelzl C, Glatt H, Meinl W, Sontag G, Haidinger G, Kundi M, Simic T, Chakraborty A, Bichler J, Ferk F, Angelis K, Nersesyan A, Knasmüller S. Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial. Molecular Nutrition & Food Research. 52: 330-41. PMID 18293303 DOI: 10.1002/Mnfr.200700406 |
0.359 |
|
| 2008 |
Kollock R, Frank H, Seidel A, Meinl W, Glatt H. Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 245: 65-75. PMID 18242813 DOI: 10.1016/J.Tox.2007.12.012 |
0.368 |
|
| 2008 |
Meinl W, Ebert B, Glatt H, Lampen A. Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 276-83. PMID 17967930 DOI: 10.1124/Dmd.107.018036 |
0.377 |
|
| 2008 |
Meinl W, Donath C, Schneider H, Sommer Y, Glatt H. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens Food and Chemical Toxicology. 46: 1249-1256. PMID 17936463 DOI: 10.1016/J.Fct.2007.08.040 |
0.392 |
|
| 2008 |
Kollock R, Meinl W, Schneider H, Batke M, Frank H, Seidel A, Glatt H. Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents. Biochemical Pharmacology. 75: 527-37. PMID 17920042 DOI: 10.1016/J.Bcp.2007.08.030 |
0.394 |
|
| 2007 |
Bakhiya N, Batke M, Laake J, Monien BH, Frank H, Seidel A, Engst W, Glatt H. Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1824-31. PMID 17639024 DOI: 10.1124/Dmd.107.016964 |
0.331 |
|
| 2007 |
Geyer J, Döring B, Meerkamp K, Ugele B, Bakhiya N, Fernandes CF, Godoy JR, Glatt H, Petzinger E. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). The Journal of Biological Chemistry. 282: 19728-41. PMID 17491011 DOI: 10.1074/Jbc.M702663200 |
0.302 |
|
| 2007 |
Arlt VM, Glatt H, Gamboa da Costa G, Reynisson J, Takamura-Enya T, Phillips DH. Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 445-57. PMID 17483118 DOI: 10.1093/Toxsci/Kfm103 |
0.379 |
|
| 2007 |
Teubner W, Meinl W, Florian S, Kretzschmar M, Glatt H. Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. The Biochemical Journal. 404: 207-15. PMID 17335415 DOI: 10.1042/Bj20061431 |
0.363 |
|
| 2007 |
Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, et al. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutation Research. 628: 31-55. PMID 17293159 DOI: 10.1016/J.Mrgentox.2006.11.008 |
0.39 |
|
| 2007 |
Ku WW, Bigger A, Brambilla G, Glatt H, Gocke E, Guzzie PJ, Hakura A, Honma M, Martus HJ, Obach RS, Roberts S. Strategy for genotoxicity testing--metabolic considerations. Mutation Research. 627: 59-77. PMID 17141553 DOI: 10.1016/J.Mrgentox.2006.10.004 |
0.338 |
|
| 2006 |
Reinen J, Vriese E, Glatt H, Vermeulen NP. Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Analytical Biochemistry. 357: 85-92. PMID 16914110 DOI: 10.1016/J.Ab.2006.07.015 |
0.324 |
|
| 2006 |
Blaut M, Braune A, Wunderlich S, Sauer P, Schneider H, Glatt H. Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 44: 1940-7. PMID 16904805 DOI: 10.1016/J.Fct.2006.06.015 |
0.341 |
|
| 2006 |
Al-Buheissi SZ, Patel HR, Meinl W, Hewer A, Bryan RL, Glatt H, Miller RA, Phillips DH. N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation. Pharmacogenetics and Genomics. 16: 391-9. PMID 16708048 DOI: 10.1097/01.Fpc.0000204998.22301.09 |
0.346 |
|
| 2006 |
Bakhiya N, Stephani M, Bahn A, Ugele B, Seidel A, Burckhardt G, Glatt H. Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters. Journal of the American Society of Nephrology : Jasn. 17: 1414-21. PMID 16597690 DOI: 10.1681/Asn.2005080801 |
0.39 |
|
| 2006 |
Bauer-Marinovic M, Florian S, Müller-Schmehl K, Glatt H, Jacobasch G. Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon. Carcinogenesis. 27: 1849-59. PMID 16597648 DOI: 10.1093/Carcin/Bgl025 |
0.313 |
|
| 2006 |
Sabbioni G, Jones CR, Sepai O, Hirvonen A, Norppa H, Järventaus H, Glatt H, Pomplun D, Yan H, Brooks LR, Warren SH, Demarini DM, Liu YY. Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 559-66. PMID 16537716 DOI: 10.1158/1055-9965.Epi-05-0677 |
0.309 |
|
| 2006 |
Heine T, Glatt H, Epe B. Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability. Free Radical Biology & Medicine. 40: 801-7. PMID 16520232 DOI: 10.1016/J.Freeradbiomed.2005.10.033 |
0.352 |
|
| 2006 |
Rüfer CE, Glatt H, Kulling SE. Structural elucidation of hydroxylated metabolites of the isoflavan equol by gas chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 51-60. PMID 16199471 DOI: 10.1124/Dmd.105.004929 |
0.356 |
|
| 2006 |
Meinl W, Pabel U, Osterloh-Quiroz M, Hengstler JG, Glatt H. Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue. International Journal of Cancer. 118: 1090-7. PMID 16161050 DOI: 10.1002/Ijc.21480 |
0.429 |
|
| 2005 |
Glatt H, Meinl W. Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects. Methods in Enzymology. 400: 230-49. PMID 16399352 DOI: 10.1016/S0076-6879(05)00013-3 |
0.39 |
|
| 2005 |
Glatt H, Schneider H, Liu Y. V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutation Research. 580: 41-52. PMID 15668106 DOI: 10.1016/J.Mrgentox.2004.11.005 |
0.404 |
|
| 2004 |
Schneider H, Glatt H. Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro. The Biochemical Journal. 383: 543-9. PMID 15281911 DOI: 10.1042/Bj20040925 |
0.305 |
|
| 2004 |
Majer BJ, Kassie F, Sasaki Y, Pfau W, Glatt H, Meinl W, Darroudi F, Knasmüller S. Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells. Journal of Chromatography B. 802: 167-173. PMID 15036008 DOI: 10.1016/J.Jchromb.2003.10.042 |
0.439 |
|
| 2004 |
Glatt H, Meinl W. Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity. Carcinogenesis. 25: 779-86. PMID 14754874 DOI: 10.1093/Carcin/Bgh070 |
0.412 |
|
| 2004 |
Glatt H, Pabel U, Meinl W, Frederiksen H, Frandsen H, Muckel E. Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAαC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes Carcinogenesis. 25: 801-807. PMID 14729582 DOI: 10.1093/Carcin/Bgh077 |
0.422 |
|
| 2004 |
Glatt H, Meinl W. Pharmacogenetics of soluble sulfotransferases (SULTs) Naunyn-Schmiedebergs Archives of Pharmacology. 369: 55-68. PMID 14600802 DOI: 10.1007/S00210-003-0826-0 |
0.364 |
|
| 2003 |
Bernauer U, Glatt H, Heinrich-Hirsch B, Liu Y, Muckel E, Vieth B, Gundert-Remy U. Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1. Alternatives to Laboratory Animals : Atla. 31: 21-30. PMID 16221041 DOI: 10.1177/026119290303100104 |
0.403 |
|
| 2003 |
Kester MHA, Kaptein E, Roest TJ, Dijk CHv, Tibboel D, Meinl W, Glatt H, Coughtrie MWH, Visser TJ. Characterization of rat iodothyronine sulfotransferases. American Journal of Physiology-Endocrinology and Metabolism. 285: 592-598. PMID 12773305 DOI: 10.1152/Ajpendo.00046.2003 |
0.318 |
|
| 2003 |
Schneider H, Ma L, Glatt H. Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography B. 789: 227-237. PMID 12742114 DOI: 10.1016/S1570-0232(03)00065-5 |
0.348 |
|
| 2003 |
Arlt VM, Glatt H, Muckel E, Pabel U, Sorg BL, Seidel A, Frank H, Schmeiser HH, Phillips DH. Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells. International Journal of Cancer. Journal International Du Cancer. 105: 583-92. PMID 12740904 DOI: 10.1002/Ijc.11143 |
0.402 |
|
| 2003 |
Landes N, Pfluger P, Kluth D, Birringer M, Rühl R, Böl G, Glatt H, Brigelius-Flohé R. Vitamin E activates gene expression via the pregnane X receptor. Biochemical Pharmacology. 65: 269-273. PMID 12504802 DOI: 10.1016/S0006-2952(02)01520-4 |
0.343 |
|
| 2002 |
Engst W, Pabel U, Glatt H. Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases. Environmental Toxicology and Pharmacology. 11: 243-250. PMID 21782608 DOI: 10.1016/S1382-6689(02)00022-4 |
0.374 |
|
| 2002 |
Meinl W, Meerman JHN, Glatt H. Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium Pharmacogenetics. 12: 677-689. PMID 12464797 DOI: 10.1097/00008571-200212000-00002 |
0.396 |
|
| 2002 |
Edenharder R, Sager JW, Glatt H, Muckel E, Platt KL. Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 521: 57-72. PMID 12438004 DOI: 10.1016/S1383-5718(02)00212-7 |
0.413 |
|
| 2002 |
Arlt VM, Glatt H, Muckel E, Pabel U, Sorg BL, Schmeiser HH, Phillips DH. Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. Carcinogenesis. 23: 1937-45. PMID 12419844 DOI: 10.1093/Carcin/23.11.1937 |
0.355 |
|
| 2002 |
Teubner W, Meinl W, Glatt H. Stable expression of rat sulfotransferase 1B1 in V79 cells: activation of benzylic alcohols to mutagens Carcinogenesis. 23: 1877-1884. PMID 12419836 DOI: 10.1093/Carcin/23.11.1877 |
0.382 |
|
| 2002 |
Kester MHA, Bulduk S, Toor Hv, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MWH, Schuur AG, Brouwer A, Visser TJ. Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters. The Journal of Clinical Endocrinology and Metabolism. 87: 1142-1150. DOI: 10.1210/Jc.87.3.1142 |
0.351 |
|
| 2002 |
Glatt H, Pabel U, Muckel E, Meinl W. Activation of Polycyclic Aromatic Compounds by cDNA-Expressed Phase I and Phase II Enzymes Polycyclic Aromatic Compounds. 22: 955-967. DOI: 10.1080/10406630290104112 |
0.381 |
|
| 2002 |
Ma L, Kuhlow A, Glatt H. Ethanol Enhances the Activation of 1-Hydroxymethylpyrene to DNA Adduct-Forming Species in the Rat Polycyclic Aromatic Compounds. 22: 933-946. DOI: 10.1080/10406630290104095 |
0.384 |
|
| 2002 |
Luch A, Greim H, Buters JTM, Mahadevan B, Baird WM, Doehmer J, Seidel A, Glatt H. The Role of Cytochrome P450 1B1 in Dibenzo[ a,l ]pyrene-induced Carcinogenesis Polycyclic Aromatic Compounds. 22: 781-789. DOI: 10.1080/10406630290103933 |
0.351 |
|
| 2001 |
Glatt H, Boeing H, Engelke CEH, Ma L, Kuhlow A, Pabel U, Pomplun D, Teubner W, Meinl W. Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. Mutation Research. 482: 27-40. PMID 11535246 DOI: 10.1016/S0027-5107(01)00207-X |
0.356 |
|
| 2001 |
Williams JA, Stone EM, Fakis G, Johnson N, Cordell JA, Meinl W, Glatt H, Sim E, Phillips DH. N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics. 11: 373-88. PMID 11470991 DOI: 10.1097/00008571-200107000-00002 |
0.337 |
|
| 2001 |
Henschler R, Appel KE, Heyworth CM, Glatt H. Proliferation and differentiation of murine haemopoietic progenitor cells in stroma-free culture in the presence of metabolites of chlorinated pesticides. Toxicology in Vitro. 15: 31-37. PMID 11259867 DOI: 10.1016/S0887-2333(00)00056-4 |
0.315 |
|
| 2000 |
Glatt H. Sulfotransferases in the bioactivation of xenobiotics. Chemico-Biological Interactions. 129: 141-170. PMID 11154739 DOI: 10.1016/S0009-2797(00)00202-7 |
0.416 |
|
| 2000 |
Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology. 141: 1897-900. PMID 10803601 DOI: 10.1210/Endo.141.5.7530 |
0.318 |
|
| 2000 |
Engelke CEH, Meinl W, Boeing H, Glatt H. Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. Pharmacogenetics. 10: 163-169. PMID 10762004 DOI: 10.1097/00008571-200003000-00008 |
0.303 |
|
| 2000 |
Glatt H, Engelke CEH, Pabel U, Teubner W, Jones AL, Coughtrie MWH, Andrae U, Falany CN, Meinl W. Sulfotransferases: genetics and role in toxicology. Toxicology Letters. 112: 341-348. PMID 10720750 DOI: 10.1016/S0378-4274(99)00214-3 |
0.416 |
|
| 2000 |
Kreis P, Brandner S, Coughtrie MW, Pabel U, Meinl W, Glatt H, Andrae U. Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant. Carcinogenesis. 21: 295-9. PMID 10657971 DOI: 10.1093/Carcin/21.2.295 |
0.409 |
|
| 2000 |
Ma L, Landsiedel R, Kuhlow A, Engst W, Seidel A, Glatt H. Detection of Mercapturic Acids and Nucleoside Adducts in Blood, Urine and Feces of Rats Treated with Metabolites of Methylpyrene Polycyclic Aromatic Compounds. 21: 135-149. DOI: 10.1080/10406630008028530 |
0.335 |
|
| 1999 |
Engst W, Landsiedel R, Hermersdörfer H, Doehmer J, Glatt H. Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells. Carcinogenesis. 20: 1777-1785. PMID 10469624 DOI: 10.1093/Carcin/20.9.1777 |
0.421 |
|
| 1999 |
Curto EV, Kwong C, Hermersdörfer H, Glatt H, Santis C, Virador V, Hearing VJ, Dooley TP. Inhibitors of mammalian melanocyte tyrosinase: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors Biochemical Pharmacology. 57: 663-672. PMID 10037452 DOI: 10.1016/S0006-2952(98)00340-2 |
0.328 |
|
| 1999 |
Andrae U, Kreis P, Coughtrie MWH, Pabel U, Meinl W, Bartsch I, Glatt H. Activation of propane 2-nitronate to a genotoxicant in V79-derived cell lines engineered for the expression of rat hepatic sulfotransferases. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 439: 191-197. PMID 10023057 DOI: 10.1016/S1383-5718(98)00194-6 |
0.419 |
|
| 1998 |
Seidel A, Friedberg T, Löllmann B, Schwierzok A, Funk M, Frank H, Holler R, Oesch F, Glatt H. Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells. Carcinogenesis. 19: 1975-1981. PMID 9855012 DOI: 10.1093/Carcin/19.11.1975 |
0.387 |
|
| 1998 |
Glatt H, Davis W, Meinl W, Hermersdörfer H, Venitt S, Phillips D. Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture. Carcinogenesis. 19: 1709-1713. PMID 9806149 DOI: 10.1093/Carcin/19.10.1709 |
0.433 |
|
| 1998 |
Visser TJ, Kaptein E, Glatt H, Bartsch I, Hagen M, Coughtrie MWH. Characterization of thyroid hormone sulfotransferases Chemico-Biological Interactions. 109: 279-291. PMID 9566752 DOI: 10.1016/S0009-2797(97)00139-7 |
0.338 |
|
| 1998 |
Hagen M, Pabel U, Landsiedel R, Bartsch I, Falany CN, Glatt H. Expression of human estrogen sulfotransferase in Salmonella typhimurium: differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen Chemico-Biological Interactions. 109: 249-253. PMID 9566749 DOI: 10.1016/S0009-2797(97)00136-1 |
0.377 |
|
| 1998 |
Glatt H, Bartsch I, Christoph S, Coughtrie MWH, Falany CN, Hagen M, Landsiedel R, Pabel U, Phillips DH, Seidel A, Yamazoe Y. Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems Chemico-Biological Interactions. 109: 195-219. PMID 9566746 DOI: 10.1016/S0009-2797(97)00133-6 |
0.452 |
|
| 1998 |
Phillips DH, Davis W, Venitt S, Glatt H. I.6 Tamoxifen metabolism and activation: the reason for interspecies differences European Journal of Cancer. 34. DOI: 10.1016/S0959-8049(98)00089-6 |
0.404 |
|
| 1997 |
Luch A, Seidel A, Glatt H, Platt KL. Metabolic Activation of the (+)-S,S- And (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: Stereoselectivity, DNA Adduct Formation, and Mutagenicity in Chinese Hamster V79 Cells Chemical Research in Toxicology. 10: 1161-1170. PMID 9348439 DOI: 10.1021/Tx970005I |
0.363 |
|
| 1997 |
Glatt H. Sulfation and sulfotransferases 4: bioactivation of mutagens via sulfation. The Faseb Journal. 11: 314-321. PMID 9141497 DOI: 10.1096/Fasebj.11.5.9141497 |
0.327 |
|
| 1996 |
Rubin GL, Sharp S, Jones AL, Glatt H, Mills JA, Coughtrie MWH. Design, production and characterization of antibodies discriminating between the phenol-and monoamine-sulphating forms of human phenol sulphotransferase Xenobiotica. 26: 1113-1119. PMID 8948087 DOI: 10.3109/00498259609050256 |
0.322 |
|
| 1996 |
Rueff J, Chiapella C, Chipman J, Darroudi F, Silva I, Duvergervanbogaert M, Fonti E, Glatt H, Isern P, Laires A, Leonard A, Llagostera M, Mossesso P, Natarajan A, Palitti F, et al. Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays Mutation Research. 353: 151-176. PMID 8692190 DOI: 10.1016/0027-5107(95)00246-4 |
0.38 |
|
| 1996 |
Luch A, Seidel A, Glatt H, Oesch F, Platt KL. Correlation of the Extent of Fjord-Region Oxidation with DNA Binding and Mutagenicity of the Enantiomeric 11,12-Dihydrodiols of Dibenzo[a,l]pyrene Polycyclic Aromatic Compounds. 10: 101-108. DOI: 10.1080/10406639608034685 |
0.348 |
|
| 1996 |
Glatt H, Bartsch I, Doehmer J, Werle-schneider G. External Versus Internal Metabolic Activation of Polycyclic Aromatic Compounds in Mutagenicity Tests: A Comparison Using Heterologous Expression Systems Polycyclic Aromatic Compounds. 10: 43-50. DOI: 10.1080/10406639608034678 |
0.448 |
|
| 1995 |
Falany CN, Comer KA, Dooley TP, Glatt H. Human dehydroepiandrosterone sulfotransferase. Purification, molecular cloning, and characterization. Annals of the New York Academy of Sciences. 774: 59-72. PMID 8597484 DOI: 10.1111/J.1749-6632.1995.Tb17372.X |
0.386 |
|
| 1995 |
Glatt H, Bartsch I, Czich A, Seidel A, Falany CN. Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases. Toxicology Letters. 829-34. PMID 8597149 DOI: 10.1016/0378-4274(95)03524-9 |
0.372 |
|
| 1995 |
Jones AL, Hagen M, Coughtrie MW, Roberts RC, Glatt H. Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form. Biochemical and Biophysical Research Communications. 208: 855-62. PMID 7695643 DOI: 10.1006/Bbrc.1995.1414 |
0.363 |
|
| 1995 |
Forbes KJ, Hagen M, Glatt H, Hume R, Coughtrie MWH. Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. Molecular and Cellular Endocrinology. 112: 53-60. PMID 7589785 DOI: 10.1016/0303-7207(95)03585-U |
0.401 |
|
| 1995 |
Glatt H, Pauly K, Czich A, Falany JL, Falany CN. Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in Escherichia coli. European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 293: 173-181. PMID 7589232 DOI: 10.1016/0926-6917(95)90002-0 |
0.407 |
|
| 1994 |
Friedberg T, Becker R, Oesch F, Glatt H. Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells Carcinogenesis. 15: 171-175. PMID 8313504 DOI: 10.1093/Carcin/15.2.171 |
0.391 |
|
| 1994 |
Glatt H, Pauly K, Piée-Staffa A, Seidel A, Hornhardt S, Czich A. Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures. Toxicology Letters. 72: 13-21. PMID 8202924 DOI: 10.1016/0378-4274(94)90005-1 |
0.397 |
|
| 1994 |
Glatt H, Abu-Shqara E, Martiné U, Baidossi W, Harvey RG, Blum J. K-region oxides and imines derived from alkylated benz[a]anthracene congeners: synthesis, stability in aqueous media and mutagenicity. Mutagenesis. 9: 83-92. PMID 8201951 DOI: 10.1093/Mutage/9.2.83 |
0.348 |
|
| 1994 |
Glatt H, Werle-Schneider G, Enders N, Monnerjahn S, Pudil J, Czich A, Seidel A, Schwarz M. 1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects. Chemico-Biological Interactions. 92: 305-319. PMID 8033264 DOI: 10.1016/0009-2797(94)90072-8 |
0.391 |
|
| 1994 |
Czich A, Bartsch I, Dogra S, Hornhardt S, Glatt HR. Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations. Chemico-Biological Interactions. 92: 119-28. PMID 8033247 DOI: 10.1016/0009-2797(94)90058-2 |
0.321 |
|
| 1994 |
Glatt H, Pauly K, Frank H, Seidel A, Oesch F, Harvey RG, Werle-Schneider G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis. 15: 2605-11. PMID 7955113 DOI: 10.1093/Carcin/15.11.2605 |
0.332 |
|
| 1994 |
Glatt H, Seidel A, Harvey RG, Coughtrie MW. Activation of benzylic alcohols to mutagens by human hepatic sulphotransferases. Mutagenesis. 9: 553-7. PMID 7854148 DOI: 10.1093/Mutage/9.6.553 |
0.387 |
|
| 1994 |
Oesch F, Oesch-Bartlomowicz B, Arens J, Fahndrich F, Vogel E, Friedberg T, Glatt H. Mechanism-based Predictions of Interactions Environmental Health Perspectives. 102: 5-9. PMID 7698085 DOI: 10.1289/Ehp.94102S95 |
0.306 |
|
| 1994 |
Glatt H, Seidel A, Oesch F, Gumbsch A. Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow. Mutation Research. 309: 37-43. PMID 7519731 DOI: 10.1016/0027-5107(94)90040-X |
0.335 |
|
| 1994 |
Glatt H, Staffa-Piée A, Enders N, Baidossi W, Blum J. The presence of KCl in the exposure medium strongly influences the mutagenicity of metabolites of polycyclic aromatic hydrocarbons in Escherichia coli Mutation Research Letters. 324: 111-114. PMID 7517509 DOI: 10.1016/0165-7992(94)90054-X |
0.342 |
|
| 1994 |
Seidel A, Luch A, Platt KL, Oesch F, Glatt H. Activated Fjord-Region Metabolites of Dibenzo[a,l]pyrene: Synthesis and Mutagenic Activities of the Diastereomeric syn− and anti−11,12-Dihydrodiol 13,14-Epoxides Polycyclic Aromatic Compounds. 6: 191-198. DOI: 10.1080/10406639408031184 |
0.301 |
|
| 1994 |
Glatt H, Werle-Schneider G, Seidel A, Schwarz M. Initiation and Promotion of Enzyme-Altered Foci in Rat Liver by 1-Hydroxymethylpyrene Polycyclic Aromatic Compounds. 7: 153-160. DOI: 10.1080/10406639408014725 |
0.365 |
|
| 1994 |
Glatt H, Pudil J, Seidel A, Czich A. Stable Expression of Heterologous Sulfotransferase in V79 Cells: Activation of Primary and Secondary Benzylic Alcohols Polycyclic Aromatic Compounds. 7: 67-74. DOI: 10.1080/10406639408014714 |
0.401 |
|
| 1993 |
Kulka U, Doehmer J, Glatt H, Bauchinger M. Cytogenetic effects of promutagens in genetically engineered V79 Chinese hamster cells expressing cytochromes P450. European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 228: 299-304. PMID 8482321 DOI: 10.1016/0926-6917(93)90064-W |
0.353 |
|
| 1993 |
Glatt H, Henschler R, Frank H, Seidel A, Yang C, Abu-Shqara E, Harvey RG. Sulfotransferase-mediated mutagenicity of 1-hydroxymethylpyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions. Carcinogenesis. 14: 599-602. PMID 8472321 DOI: 10.1093/Carcin/14.4.599 |
0.367 |
|
| 1993 |
Glatt H, Wameling C, Elsberg S, Thomas H, Marquardt H, Hewer A, Phillips DH, Oesch F, Seidel A. Genotoxicity characteristics of reverse diol-epoxides of chrysene Carcinogenesis. 14: 11-19. PMID 8425257 DOI: 10.1093/Carcin/14.1.11 |
0.405 |
|
| 1993 |
Schmalix WA, Mäser H, Kiefer F, Reen R, Wiebel FJ, Gonzalez F, Seidel A, Glatt H, Greim H, Doehmer J. Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 248: 251-261. PMID 8293790 DOI: 10.1016/0926-6917(93)90052-R |
0.401 |
|
| 1993 |
Werle-Schneider G, Schwarz M, Glatt H. Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats Carcinogenesis. 14: 2267-2270. PMID 8242853 DOI: 10.1093/Carcin/14.11.2267 |
0.377 |
|
| 1992 |
Glatt H, Anklam E, Robertson LW. Biphenyl and fluorinated derivatives: liver enzyme-mediated mutagenicity detected in Salmonella typhimurium and Chinese hamster V79 cells. Mutation Research. 281: 151-6. PMID 1371835 DOI: 10.1016/0165-7992(92)90001-X |
0.442 |
|
| 1992 |
Glatt H, Pertz H, Kasper R, Eich E. Clavine alkaloids and derivatives as mutagens detected in the Ames test. Anti-Cancer Drugs. 3: 609-14. PMID 1288732 DOI: 10.1097/00001813-199212000-00008 |
0.414 |
|
| 1991 |
Oesch F, Gath I, Igarashi T, Glatt H, Oesch-Bartlomowicz B, Thomas H. Role of the well-known basic and recently discovered acidic glutathione S-transferases in the control of genotoxic metabolites. Advances in Experimental Medicine and Biology. 283: 25-39. PMID 2068991 DOI: 10.1007/978-1-4684-5877-0_3 |
0.334 |
|
| 1991 |
Krämer A, Frank H, Setiabudi F, Oesch F, Glatt H. Influence of the level of cytosolic epoxide hydrolase on the induction of sister chromatid exchanges by trans-β-ethylstyrene 7,8-oxide in human lymphocytes Biochemical Pharmacology. 42: 2147-2152. PMID 1958232 DOI: 10.1016/0006-2952(91)90350-E |
0.323 |
|
| 1991 |
Phillips DH, Hewer A, Seidel A, Steinbrecher T, Schrode R, Oesch F, Glatt H. Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons. Chemico-Biological Interactions. 80: 177-186. PMID 1934148 DOI: 10.1016/0009-2797(91)90023-Z |
0.371 |
|
| 1991 |
Glatt H, Martiné U, Baidossi W, Blum J. Strong influence of the exposure medium on mutagenicity in the Ames test: 7-methylbenz[α]anthracene-5, 6-oxide Mutagenesis. 6: 537-540. PMID 1800902 DOI: 10.1093/Mutage/6.6.537 |
0.322 |
|
| 1991 |
Wölfel C, Platt K, Dogra S, Glatt H, Wächter F, Doehmer J. Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17β‐estradiol and 2‐aminofluorene in V79 Chinese hamster cells Molecular Carcinogenesis. 4: 489-498. PMID 1793487 DOI: 10.1002/Mc.2940040613 |
0.35 |
|
| 1990 |
Glatt H, Utesch D, Herbst M, Oesch F. Mutagenicity experiments on L-cysteine and D-penicillamine using V79 cells as indicators and for metabolic activation. Mutation Research Letters. 243: 187-193. PMID 2407952 DOI: 10.1016/0165-7992(90)90089-3 |
0.343 |
|
| 1990 |
Glatt H, Gemperlein I, Setiabudi F, Platt KL, Oesch F. Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds. Mutagenesis. 5: 241-250. PMID 2385178 DOI: 10.1093/Mutage/5.3.241 |
0.423 |
|
| 1990 |
Glatt H, Henschler R, Phillips DH, Blake JW, Steinberg P, Seidel A, Oesch F. Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells. Environmental Health Perspectives. 88: 43-48. PMID 2272332 DOI: 10.1289/Ehp.908843 |
0.349 |
|
| 1990 |
Hradec J, Seidel A, Platt KL, Glatt HR, Oesch F, Koblyakov V. The intiator tRNA acceptance assay as a short-term test for carcinogens. 6. Results with 78 polycyclic aromatic compounds Carcinogenesis. 11: 1921-1926. PMID 2225323 DOI: 10.1093/Carcin/11.11.1921 |
0.302 |
|
| 1990 |
Glatt H, Witz aG. Studies on the induction of gene mutations in bacterial and mammalian cells by the ring-opened benzene metabolites trans,trans-muconaldehyde and trans,trans-muconic acid. Mutagenesis. 5: 263-266. PMID 2200946 DOI: 10.1093/Mutage/5.3.263 |
0.308 |
|
| 1990 |
Glatt H. Endogenous mutagens derived from amino acids Mutation Research. 238: 235-243. PMID 2188121 DOI: 10.1016/0165-1110(90)90015-4 |
0.328 |
|
| 1989 |
Ludewig G, Dogra S, Glatt H. Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells. Environmental Health Perspectives. 82: 223-228. PMID 2792044 DOI: 10.1289/Ehp.8982223 |
0.337 |
|
| 1989 |
Glatt H, Padykula R, Berchtold GA, Ludewig G, Platt KL, Klein J, Oesch F. Multiple activation pathways of benzene leading to products with varying genotoxic characteristics. Environmental Health Perspectives. 82: 81-9. PMID 2676505 DOI: 10.1289/Ehp.898281 |
0.367 |
|
| 1989 |
Doehmer J, Dogra S, Edigkaufer M, Molitor E, Siegert P, Friedberg T, Glatt H, Platt K, Seidel A, Thomas H, Oesch F. Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems. Archives of Toxicology. 13: 164-168. PMID 2673143 DOI: 10.1007/978-3-642-74117-3_22 |
0.387 |
|
| 1989 |
Glatt H. Mutagenicity spectra in Salmonella typhimurium strains of glutathione, L-cysteine and active oxygen species. Mutagenesis. 4: 221-227. PMID 2543888 DOI: 10.1093/Mutage/4.3.221 |
0.319 |
|
| 1988 |
Doehmer J, Dogra S, Friedberg T, Monier S, Adesnik M, Glatt H, Oesch F. Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1. Proceedings of the National Academy of Sciences of the United States of America. 85: 5769-5773. PMID 3137560 DOI: 10.1073/Pnas.85.16.5769 |
0.377 |
|
| 1987 |
Glatt H, Seidel A, Ribeiro O, Kirkby C, Hirom P, Oesch F. Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene. Carcinogenesis. 8: 1621-1627. PMID 3311446 DOI: 10.1093/Carcin/8.11.1621 |
0.351 |
|
| 1986 |
Oesch F, Lafranconi M, Glatt H. Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediates Advances in Experimental Medicine and Biology. 197: 53-61. PMID 3766279 DOI: 10.1007/978-1-4684-5134-4_5 |
0.392 |
|
| 1986 |
Glatt H, Shtelzer S, Sheradsky T, Blum J, Oesch F. Mutagenicity of N-substituted phenanthrene 9,10-imines in Salmonella typhimurium and Chinese hamster V79 cells. Environmental Mutagenesis. 8: 829-37. PMID 3536471 DOI: 10.1002/Em.2860080606 |
0.36 |
|
| 1986 |
Glatt H, Oesch F, Neumann H. V79 Chinese hamster cells deacetylate trans-N-acetoxy-4-acetylaminostilbene and trans-N-hydroxy-4-acetylaminostilbene to mutagenic and cytotoxic metabolites. Cell Biology and Toxicology. 2: 213-221. PMID 3267447 DOI: 10.1007/Bf00122690 |
0.323 |
|
| 1986 |
Lafranconi WM, Glatt H, Oesch F. Xenobiotic metabolizing enzymes of rat liver nonparenchymal cells Toxicology and Applied Pharmacology. 84: 500-511. PMID 3088773 DOI: 10.1016/0041-008X(86)90255-3 |
0.404 |
|
| 1985 |
Glatt H, Oesch F. Mutagenicity of cysteine and penicillamine and its enantiomeric selectivity. Biochemical Pharmacology. 34: 3725-3728. PMID 3902028 DOI: 10.1016/0006-2952(85)90237-0 |
0.32 |
|
| 1985 |
Glatt H, Bücker M, Platt KL, Oesch F. Host-mediated mutagenicity experiments with benzo[a]pyrene and two of its metabolites. Mutation Research\/Genetic Toxicology. 156: 163-169. PMID 3889634 DOI: 10.1016/0165-1218(85)90059-X |
0.316 |
|
| 1985 |
Glatt H, Oesch F. Propyldazine is mutagenic in Salmonella typhimurium and Escherichia coli: distinct specificity for strains TA1537 and TA97. Teratogenesis Carcinogenesis and Mutagenesis. 5: 339-345. PMID 2867616 DOI: 10.1002/Tcm.1770050504 |
0.304 |
|
| 1983 |
Glatt H, Jung R, Oesch F. Bacterial mutagenicity investigation of epoxides: drugs, drug metabolites, steroids and pesticides Mutation Research. 111: 99-118. PMID 6355833 DOI: 10.1016/0027-5107(83)90056-8 |
0.325 |
|
| 1983 |
Glatt H, Protic-SabljiC M, Oesch F. Mutagenicity of glutathione and cysteine in the Ames test. Science. 220: 961-963. PMID 6342137 DOI: 10.1126/Science.6342137 |
0.356 |
|
| 1982 |
Glatt H, Cooper C, Grover P, Sims P, Bentley P, Merdes M, Waechter F, Vogel K, Guenthner T, Oesch F. Inactivation of a diol epoxide by dihydrodiol dehydrogenase but not by two epoxide hydrolases Science. 215: 1507-1509. PMID 7038877 DOI: 10.1126/Science.7038877 |
0.338 |
|
| 1981 |
Glatt H, Vogel K, Bentley P, Sims P, Oesch F. Large differences in metabolic activation and inactivation of chemically closely related compounds: effects of pure enzymes and enzyme induction on the mutagenicity of the twelve monomethylated benz[a]anthracenes, 7,12-dimethylbenz[a]anthracene and benz[a]anthracenes in the Ames test Carcinogenesis. 2: 813-821. PMID 7296767 DOI: 10.1093/Carcin/2.9.813 |
0.363 |
|
| 1981 |
Glatt H, Balle Ld, Oesch F. Ethanol- or acetone-pretreatment of mice strongly enhances the bacterial mutagenicity of dimethylnitrosamine in assays mediated by liver subcellular fraction, but not in host-mediated assays. Carcinogenesis. 2: 1057-1061. PMID 7028306 DOI: 10.1093/Carcin/2.10.1057 |
0.365 |
|
| 1981 |
Oesch F, Bücker M, Glatt HR. Activation of phenanthrene to mutagenic metabolites and evidence for at least two different activation pathways Mutation Research. 81: 1-10. PMID 7019683 DOI: 10.1016/0027-5107(81)90081-6 |
0.313 |
|
| 1979 |
Glatt H, Ohlsson A, Agurell S, Oesch F. Δ1-Tetrahydrocannabinol and 1α,2α-epoxyhexahydrocannabinol: Mutagenicity investigation in the ames test Mutation Research\/Genetic Toxicology. 66: 329-335. PMID 379628 DOI: 10.1016/0165-1218(79)90043-0 |
0.349 |
|
| 1977 |
Oesch F, Glatt H, Schmassmann H. The apparent ubiquity of epoxide hydratase in rat organs Biochemical Pharmacology. 26: 603-607. PMID 856190 DOI: 10.1016/0006-2952(77)90032-6 |
0.352 |
|
| 1977 |
Glatt H, Oesch F. Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization. Archives of Toxicology. 39: 87-96. PMID 341852 DOI: 10.1007/Bf00343278 |
0.352 |
|
| 1977 |
Bentley P, Oesch F, Glatt H. Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene. Archives of Toxicology. 39: 65-75. PMID 341851 DOI: 10.1007/Bf00343276 |
0.375 |
|
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