Michael K. Rosen - Publications

University of Texas Southwestern Medical Center, Dallas, TX, United States 

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ellis R, Maskal S, Prabhu A, Petro C, Beffa L, Rosen M, Miller B, Krpata D. Surgical approaches for core abdominal injuries: a review of the Abdominal Core Health Quality Collaborative database. Surgical Endoscopy. PMID 37592045 DOI: 10.1007/s00464-023-10350-0  0.327
2023 Melland-Smith M, Miller B, Petro C, Beffa L, Prabhu A, Krpata D, LaBelle M, Tamer R, Rosen M. Single-staged retromuscular abdominal wall reconstruction with mesh at the time of ostomy reversal: are we crossing the line? An ACHQC Analysis. Surgical Endoscopy. PMID 37353652 DOI: 10.1007/s00464-023-10176-w  0.336
2023 Wang HY, Chan SH, Dey S, Castello-Serrano I, Rosen MK, Ditlev JA, Levental KR, Levental I. Coupling of protein condensates to ordered lipid domains determines functional membrane organization. Science Advances. 9: eadf6205. PMID 37126554 DOI: 10.1126/sciadv.adf6205  0.719
2023 Maskal S, Miller B, Ellis R, Phillips S, Prabhu A, Beffa L, Krpata D, Rosenblatt S, Rosen M, Petro C. Mediumweight polypropylene mesh fractures after open retromuscular ventral hernia repair: incidence and associated risk factors. Surgical Endoscopy. PMID 37038022 DOI: 10.1007/s00464-023-10039-4  0.329
2023 Maskal S, Ellis R, Prabhu A, Miller B, Beffa L, Krpata D, Rosen M, Petro C. Injuries incurred from minimally invasive access for abdominal surgery. Surgical Endoscopy. PMID 36997650 DOI: 10.1007/s00464-023-10031-y  0.326
2022 Ali R, Zahm JA, Rosen MK. Bound nucleotide can control the dynamic architecture of monomeric actin. Nature Structural & Molecular Biology. 29: 320-328. PMID 35332323 DOI: 10.1038/s41594-022-00743-5  0.792
2022 Case LB, De Pasquale M, Henry L, Rosen MK. Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation. Elife. 11. PMID 35049497 DOI: 10.7554/eLife.72588  0.756
2021 Peeples W, Rosen MK. Mechanistic dissection of increased enzymatic rate in a phase-separated compartment. Nature Chemical Biology. 17: 693-702. PMID 34035521 DOI: 10.1038/s41589-021-00801-x  0.773
2021 Zhemkov V, Ditlev JA, Lee WR, Wilson M, Liou J, Rosen MK, Bezprozvanny I. The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains. Elife. 10. PMID 33973848 DOI: 10.7554/eLife.65192  0.702
2020 Lyon AS, Peeples WB, Rosen MK. A framework for understanding the functions of biomolecular condensates across scales. Nature Reviews. Molecular Cell Biology. PMID 33169001 DOI: 10.1038/s41580-020-00303-z  0.782
2020 Springhower CE, Rosen MK, Chook YM. Karyopherins and condensates. Current Opinion in Cell Biology. 64: 112-123. PMID 32474299 DOI: 10.1016/J.Ceb.2020.04.003  0.661
2020 Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, ... ... Rosen MK, et al. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nature Cell Biology. PMID 32451441 DOI: 10.1038/S41556-020-0519-7  0.747
2020 Wang H, Diaz-Rohrer B, Levental KR, Ditlev JA, Rosen MK, Levental I. Coupling between Cytoplasmic Protein Phase Separation and Cholesterol-Rich Domains in the Plasma Membrane Facilitates T Cell Activation Biophysical Journal. 118: 322a. DOI: 10.1016/J.Bpj.2019.11.1811  0.721
2019 Kim S, Kalappurakkal JM, Mayor S, Rosen MK. Phosphorylation of Nephrin induces phase separated domains that move through actomyosin contraction. Molecular Biology of the Cell. mbcE18120823. PMID 31599693 DOI: 10.1091/Mbc.E18-12-0823  0.59
2019 Ali R, Clark LD, Zahm JA, Lemoff A, Ramesh K, Rosenbaum DM, Rosen MK. Improved strategy for isoleucine H/C methyl labeling in Pichia pastoris. Journal of Biomolecular Nmr. PMID 31541396 DOI: 10.1007/S10858-019-00281-1  0.777
2019 Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK. A composition-dependent molecular clutch between T cell signaling condensates and actin. Elife. 8. PMID 31268421 DOI: 10.7554/Elife.42695  0.738
2019 Case LB, Ditlev JA, Rosen MK. Regulation of Transmembrane Signaling by Phase Separation. Annual Review of Biophysics. PMID 30951647 DOI: 10.1146/Annurev-Biophys-052118-115534  0.788
2019 Case LB, Zhang X, Ditlev JA, Rosen MK. Stoichiometry controls activity of phase-separated clusters of actin signaling proteins. Science (New York, N.Y.). 363: 1093-1097. PMID 30846599 DOI: 10.1126/Science.Aau6313  0.818
2019 Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK. Author response: A composition-dependent molecular clutch between T cell signaling condensates and actin Elife. DOI: 10.7554/Elife.42695.061  0.706
2019 Kim J, Ditlev J, Rosen MK. Abstract B169: Engineering phase separation of multivalent signaling proteins through the solubility of folded protein domains Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B169  0.743
2018 Ditlev JA, Case LB, Rosen MK. Who's in and Who's Out-Compositional Control of Biomolecular Condensates. Journal of Molecular Biology. PMID 30099028 DOI: 10.1016/J.Jmb.2018.08.003  0.786
2018 Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, et al. Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell. 173: 693-705.e22. PMID 29677513 DOI: 10.1016/J.Cell.2018.03.003  0.796
2018 Protter DSW, Rao BS, Van Treeck B, Lin Y, Mizoue L, Rosen MK, Parker R. Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly. Cell Reports. 22: 1401-1412. PMID 29425497 DOI: 10.1016/J.Celrep.2018.01.036  0.383
2018 Vega A, Ditlev J, Koster D, Su X, Vale R, Mayor S, Rosen MK, Jaqaman K. Differential LAT Microcluster Composition and ACTIN-Dependent Movement at the Immunological Synapse Center Biophysical Journal. 114: 201a. DOI: 10.1016/J.Bpj.2017.11.1123  0.682
2017 Huang WYC, Ditlev JA, Chiang HK, Rosen MK, Groves JT. Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation. Journal of the American Chemical Society. 139: 18009-18015. PMID 29182244 DOI: 10.1021/Jacs.7B09387  0.743
2017 Harmon TS, Holehouse AS, Rosen MK, Pappu RV. Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins. Elife. 6. PMID 29091028 DOI: 10.7554/Elife.30294  0.347
2017 Chen B, Chou HT, Brautigam CA, Xing W, Yang S, Henry L, Doolittle LK, Walz T, Rosen MK. Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites. Elife. 6. PMID 28949297 DOI: 10.7554/Elife.29795  0.697
2017 Lin Y, Currie SL, Rosen MK. Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs. The Journal of Biological Chemistry. PMID 28924037 DOI: 10.1074/Jbc.M117.800466  0.361
2017 Su X, Ditlev JA, Rosen MK, Vale RD. Reconstitution of TCR Signaling Using Supported Lipid Bilayers. Methods in Molecular Biology (Clifton, N.J.). 1584: 65-76. PMID 28255696 DOI: 10.1007/978-1-4939-6881-7_5  0.746
2017 Banani SF, Lee HO, Hyman AA, Rosen MK. Biomolecular condensates: organizers of cellular biochemistry. Nature Reviews. Molecular Cell Biology. PMID 28225081 DOI: 10.1038/Nrm.2017.7  0.361
2017 Chen B, Chou H, Brautigam CA, Xing W, Yang S, Henry L, Doolittle LK, Walz T, Rosen MK. Author response: Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites Elife. DOI: 10.7554/Elife.29795.023  0.335
2016 Srinivasan N, Gordon O, Ahrens S, Franz A, Deddouche S, Chakravarty P, Phillips D, Yunus AA, Rosen MK, Valente RS, Teixeira L, Thompson B, Dionne MS, Wood W, Reis E Sousa C. Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster. Elife. 5. PMID 27871362 DOI: 10.7554/Elife.19662  0.331
2016 Jia D, Zhang JS, Li F, Wang J, Deng Z, White MA, Osborne DG, Phillips-Krawczak C, Gomez TS, Li H, Singla A, Burstein E, Billadeau DD, Rosen MK. Structural and mechanistic insights into regulation of the retromer coat by TBC1d5. Nature Communications. 7: 13305. PMID 27827364 DOI: 10.1038/Ncomms13305  0.624
2016 Rujirawanich J, Kim S, Ma AJ, Butler JR, Wang Y, Wang C, Rosen M, Posner B, Nijhawan D, Ready JM. Synthesis and biological evaluation of kibdelone C and simplified derivatives. Journal of the American Chemical Society. PMID 27459345 DOI: 10.1021/Jacs.6B05484  0.494
2016 Pak CW, Kosno M, Holehouse AS, Padrick SB, Mittal A, Ali R, Yunus AA, Liu DR, Pappu RV, Rosen MK. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein. Molecular Cell. 63: 72-85. PMID 27392146 DOI: 10.1016/J.Molcel.2016.05.042  0.741
2016 Banani SF, Rice AM, Peeples WB, Lin Y, Jain S, Parker R, Rosen MK. Compositional Control of Phase-Separated Cellular Bodies. Cell. PMID 27374333 DOI: 10.1016/J.Cell.2016.06.010  0.778
2016 Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science (New York, N.Y.). PMID 27056844 DOI: 10.1126/Science.Aad9964  0.782
2016 Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S. Correction: Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. The Journal of Cell Biology. PMID 27002172 DOI: 10.1083/Jcb.20150808103082016C  0.636
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Rosen MK, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882  0.431
2016 Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S. Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. The Journal of Cell Biology. PMID 26903538 DOI: 10.1083/Jcb.201508081  0.693
2016 Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. PMID 26894386 DOI: 10.1007/S10858-016-0016-2  0.748
2016 Su X, Ditlev J, Hui E, Rosen M, Vale R. Abstract B101: Mechanism of T cell activation by phase separation Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B101  0.743
2016 Vega AR, Ditlev JA, Rosen MK, Jaqaman K. Quantitative Analysis of Cortical Actin-Membrane Microcluster Interactions Biophysical Journal. 110: 330a. DOI: 10.1016/J.Bpj.2015.11.1775  0.725
2015 Banjade S, Wu Q, Mittal A, Peeples WB, Pappu RV, Rosen MK. Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553976 DOI: 10.1073/Pnas.1508778112  0.812
2015 Lin Y, Protter DS, Rosen MK, Parker R. Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins. Molecular Cell. PMID 26412307 DOI: 10.1016/J.Molcel.2015.08.018  0.348
2015 Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. 62: 239-45. PMID 26025061 DOI: 10.1007/S10858-015-9939-2  0.783
2014 McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ. Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation. Current Biology : Cb. 24: 1678. PMID 28903028 DOI: 10.1016/J.Cub.2014.07.004  0.521
2014 Banjade S, Rosen MK. Phase transitions of multivalent proteins can promote clustering of membrane receptors. Elife. 3. PMID 25321392 DOI: 10.7554/Elife.04123  0.376
2014 Chen XJ, Squarr AJ, Stephan R, Chen B, Higgins TE, Barry DJ, Martin MC, Rosen MK, Bogdan S, Way M. Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton. Developmental Cell. 30: 569-84. PMID 25203209 DOI: 10.1016/J.Devcel.2014.08.001  0.715
2014 McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ. Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. Current Biology : Cb. 24: 1670-6. PMID 24980502 DOI: 10.1016/J.Cub.2014.06.024  0.552
2014 Dodd DA, Worth RG, Rosen MK, Grinstein S, van Oers NS, Hansen EJ. The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase. Mbio. 5: e01178-14. PMID 24902122 DOI: 10.1128/Mbio.01178-14  0.38
2014 Chen B, Padrick SB, Henry L, Rosen MK. Biochemical reconstitution of the WAVE regulatory complex. Methods in Enzymology. 540: 55-72. PMID 24630101 DOI: 10.1016/B978-0-12-397924-7.00004-2  0.814
2014 Chia PH, Chen B, Li P, Rosen MK, Shen K. Local F-actin network links synapse formation and axon branching. Cell. 156: 208-20. PMID 24439377 DOI: 10.1016/J.Cell.2013.12.009  0.656
2014 Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK. The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell. 156: 195-207. PMID 24439376 DOI: 10.1016/J.Cell.2013.11.048  0.827
2014 Banjade S, Rosen MK. Author response: Phase transitions of multivalent proteins can promote clustering of membrane receptors Elife. DOI: 10.7554/Elife.04123.026  0.308
2014 Harmon TS, Rosen MK, Pappu RV. Coarse Grain Models Highlight the Importance of Flexible Disordered Linkers as Determinants of the Phase Behavior in Polyvalent Proteins Biophysical Journal. 106: 481a. DOI: 10.1016/J.Bpj.2013.11.2718  0.342
2014 Rosen MK. Phase Separation of Multi-Valent Signaling Proteins Biophysical Journal. 106: 36a. DOI: 10.1016/J.Bpj.2013.11.271  0.357
2013 Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK. The bacterial effector VopL organizes actin into filament-like structures. Cell. 155: 423-34. PMID 24120140 DOI: 10.1016/J.Cell.2013.09.019  0.808
2013 Smith BA, Padrick SB, Doolittle LK, Daugherty-Clarke K, Corrêa IR, Xu MQ, Goode BL, Rosen MK, Gelles J. Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation. Elife. 2: e01008. PMID 24015360 DOI: 10.7554/Elife.01008  0.756
2013 Doolittle LK, Rosen MK, Padrick SB. Measurement and analysis of in vitro actin polymerization. Methods in Molecular Biology (Clifton, N.J.). 1046: 273-93. PMID 23868594 DOI: 10.1007/978-1-62703-538-5_16  0.748
2013 Doolittle LK, Rosen MK, Padrick SB. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 1046: 251-71. PMID 23868593 DOI: 10.1007/978-1-62703-538-5_15  0.758
2013 Doolittle LK, Rosen MK, Padrick SB. Purification of native Arp2/3 complex from bovine thymus. Methods in Molecular Biology (Clifton, N.J.). 1046: 231-50. PMID 23868592 DOI: 10.1007/978-1-62703-538-5_14  0.743
2013 Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 152: 1051-64. PMID 23452853 DOI: 10.1016/J.Cell.2013.01.051  0.572
2013 Smith BA, Padrick SB, Doolittle LK, Daugherty-Clarke K, Corrêa IR, Xu M, Goode BL, Rosen MK, Gelles J. Author response: Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation Elife. DOI: 10.7554/Elife.01008.023  0.727
2013 Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Rosen MK. The bacterial effector VopL organizes actin into filament-like structures Cell. 155: 423-434. DOI: 10.1016/j.cell.2013.09.019  0.782
2012 Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, ... ... Rosen M, et al. In support of the BMRB. Nature Structural & Molecular Biology. 19: 854-60. PMID 22955930 DOI: 10.1038/Nsmb.2371  0.617
2012 Rizo J, Rosen MK, Gardner KH. Enlightening molecular mechanisms through study of protein interactions Journal of Molecular Cell Biology. 4: 270-283. PMID 22735643 DOI: 10.1093/Jmcb/Mjs036  0.565
2012 Jia D, Gomez TS, Billadeau DD, Rosen MK. Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Molecular Biology of the Cell. 23: 2352-61. PMID 22513087 DOI: 10.1091/Mbc.E11-12-1059  0.647
2012 Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK. Phase transitions in the assembly of multivalent signalling proteins. Nature. 483: 336-40. PMID 22398450 DOI: 10.1038/Nature10879  0.794
2011 Li P, Martins IR, Rosen MK. The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements. Journal of Biomolecular Nmr. 51: 57-70. PMID 21947915 DOI: 10.1007/S10858-011-9541-1  0.645
2011 Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK. Mechanism of actin filament nucleation by the bacterial effector VopL. Nature Structural & Molecular Biology. 18: 1068-74. PMID 21873984 DOI: 10.1038/Nsmb.2110  0.784
2011 Padrick SB, Doolittle LK, Brautigam CA, King DS, Rosen MK. Arp2/3 complex is bound and activated by two WASP proteins. Proceedings of the National Academy of Sciences of the United States of America. 108: E472-9. PMID 21676863 DOI: 10.1073/Pnas.1100236108  0.778
2010 Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK. Structure and control of the actin regulatory WAVE complex. Nature. 468: 533-8. PMID 21107423 DOI: 10.1038/Nature09623  0.813
2010 Otomo T, Tomchick DR, Otomo C, Machius M, Rosen MK. Crystal structure of the Formin mDia1 in autoinhibited conformation. Plos One. 5. PMID 20927343 DOI: 10.1371/Journal.Pone.0012896  0.774
2010 Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA. Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Analytical Biochemistry. 407: 89-103. PMID 20667444 DOI: 10.1016/J.Ab.2010.07.017  0.712
2010 Strickland D, Yao X, Gawlak G, Rosen MK, Gardner KH, Sosnick TR. Rationally improving LOV domain-based photoswitches. Nature Methods. 7: 623-6. PMID 20562867 DOI: 10.1038/Nmeth.1473  0.515
2010 Padrick SB, Rosen MK. Physical mechanisms of signal integration by WASP family proteins. Annual Review of Biochemistry. 79: 707-35. PMID 20533885 DOI: 10.1146/Annurev.Biochem.77.060407.135452  0.762
2010 Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. The Journal of Experimental Medicine. 207: 1145-52. PMID 20513746 DOI: 10.1084/Jem.20091245  0.302
2010 Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, Billadeau DD. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proceedings of the National Academy of Sciences of the United States of America. 107: 10442-7. PMID 20498093 DOI: 10.1073/Pnas.0913293107  0.621
2010 Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 140: 246-56. PMID 20141838 DOI: 10.1107/S0108767311097042  0.776
2010 ROSEN MK, SCHREIBER SL. ChemInform Abstract: Natural Products as a Probe of Cellular Functions: Studies of Immunophilins Cheminform. 23: no-no. DOI: 10.1002/CHIN.199229318  0.313
2009 Vingadassalom D, Kazlauskas A, Skehan B, Cheng HC, Magoun L, Robbins D, Rosen MK, Saksela K, Leong JM. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proceedings of the National Academy of Sciences of the United States of America. 106: 6754-9. PMID 19366662 DOI: 10.1073/Pnas.0809131106  0.798
2009 Ismail AM, Padrick SB, Chen B, Umetani J, Rosen MK. The WAVE regulatory complex is inhibited. Nature Structural & Molecular Biology. 16: 561-3. PMID 19363480 DOI: 10.1038/Nsmb.1587  0.792
2009 Beel K, Cotter MM, Blatny J, Bond J, Lucas G, Green F, Vanduppen V, Leung DW, Rooney S, Smith OP, Rosen MK, Vandenberghe P. A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene British Journal of Haematology. 144: 120-126. PMID 19006568 DOI: 10.1111/J.1365-2141.2008.07416.X  0.607
2009 Rosen MK, Li P, Martins IR, Amarasinghe GK, Yu B, Umetani J. Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein Biophysical Journal. 96: 3a. DOI: 10.1016/J.Bpj.2008.12.907  0.78
2008 Padrick SB, Cheng HC, Ismail AM, Panchal SC, Doolittle LK, Kim S, Skehan BM, Umetani J, Brautigam CA, Leong JM, Rosen MK. Hierarchical regulation of WASP/WAVE proteins. Molecular Cell. 32: 426-38. PMID 18995840 DOI: 10.1016/J.Molcel.2008.10.012  0.825
2008 Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, Leong JM. Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. Plos Pathogens. 4: e1000191. PMID 18974829 DOI: 10.1371/Journal.Ppat.1000191  0.796
2008 Leung DW, Otomo C, Chory J, Rosen MK. Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway Proceedings of the National Academy of Sciences of the United States of America. 105: 12797-12802. PMID 18728185 DOI: 10.1073/Pnas.0801232105  0.692
2008 Cheng HC, Skehan BM, Campellone KG, Leong JM, Rosen MK. Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature. 454: 1009-13. PMID 18650809 DOI: 10.1038/Nature07160  0.797
2008 Yao X, Rosen MK, Gardner KH. Estimation of the available free energy in a LOV2-Jα photoswitch Nature Chemical Biology. 4: 491-497. PMID 18604202 DOI: 10.1038/Nchembio.99  0.524
2008 Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nature Structural & Molecular Biology. 15: 613-8. PMID 18488041 DOI: 10.1038/Nsmb.1428  0.767
2008 Cheng H, Skehan B, Campellone K, Leong J, Rosen M. Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K42/Pdb  0.764
2007 Liverman ADB, Cheng HC, Trosky JE, Leung DW, Yarbrough ML, Burdette DL, Rosen MK, Orth K. Arp2/3-independent assembly of actin by Vibrio type III effector VopL Proceedings of the National Academy of Sciences of the United States of America. 104: 17117-17122. PMID 17942696 DOI: 10.1073/Pnas.0703196104  0.794
2007 Ferguson AD, Amezcua CA, Halabi NM, Chelliah Y, Rosen MK, Ranganathan R, Deisenhofer J. Signal transduction pathway of TonB-dependent transporters. Proceedings of the National Academy of Sciences of the United States of America. 104: 513-8. PMID 17197416 DOI: 10.1073/Pnas.0609887104  0.368
2007 Yao X, Gardner K, Rosen M. Lit‐structure in the dark: conformational dynamics of phototropin LOV2 domain by relaxation NMR The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A270-B  0.507
2007 Rosen M, Cheng H, Doolittle L, Ismail A, Padrick S, Panchal S. Actin Regulation by WASP and WAVE The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A208-A  0.776
2006 Seth A, Otomo C, Rosen MK. Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1. The Journal of Cell Biology. 174: 701-13. PMID 16943183 DOI: 10.1083/Jcb.200605006  0.769
2006 Tskvitaria-Fuller I, Seth A, Mistry N, Gu H, Rosen MK, Wülfing C. Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization. Journal of Immunology (Baltimore, Md. : 1950). 177: 1708-20. PMID 16849480 DOI: 10.4049/Jimmunol.177.3.1708  0.739
2006 Leung DW, Morgan DM, Rosen MK. Biochemical properties and inhibitors of (N-)WASP Methods in Enzymology. 406: 281-296. PMID 16472665 DOI: 10.1016/S0076-6879(06)06021-6  0.661
2006 Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. The Journal of Biological Chemistry. 281: 3513-20. PMID 16293614 DOI: 10.1074/Jbc.M509416200  0.676
2006 Cotter MM, Beel K, Bond J, Lucas G, Greene F, Leung D, Rooney S, Smith OP, Rosen MK, Vandenberghe P. X-Linked Neutropenia with a I294T Mutation of the Wiskott-Aldrich Syndrome Gene. Blood. 108: 1278-1278. DOI: 10.1182/Blood.V108.11.1278.1278  0.598
2005 Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 44: 15257-68. PMID 16285729 DOI: 10.1021/Bi051126H  0.655
2005 Kreishman-Deitrick M, Goley ED, Burdine L, Denison C, Egile C, Li R, Murali N, Kodadek TJ, Welch MD, Rosen MK. NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein. Biochemistry. 44: 15247-56. PMID 16285728 DOI: 10.1021/Bi051065N  0.372
2005 Shemesh T, Otomo T, Rosen MK, Bershadsky AD, Kozlov MM. A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox. The Journal of Cell Biology. 170: 889-93. PMID 16157699 DOI: 10.1083/Jcb.200504156  0.76
2005 Otomo T, Rosen MK. [Structure and function of Formin homology 2 domain]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 50: 1088-93. PMID 16083047  0.734
2005 Otomo T, Otomo C, Tomchick DR, Machius M, Rosen MK. Structural basis of Rho GTPase-mediated activation of the formin mDia1. Molecular Cell. 18: 273-81. PMID 15866170 DOI: 10.1016/J.Molcel.2005.04.002  0.785
2005 Leung DW, Rosen MK. The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein Proceedings of the National Academy of Sciences of the United States of America. 102: 5685-5690. PMID 15821030 DOI: 10.1073/Pnas.0406472102  0.662
2005 Otomo T, Tomchick DR, Otomo C, Panchal SC, Machius M, Rosen MK. Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature. 433: 488-94. PMID 15635372 DOI: 10.1038/Nature03251  0.8
2004 Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nature Structural & Molecular Biology. 11: 747-55. PMID 15235593 DOI: 10.1038/Nsmb796  0.63
2004 Buck M, Xu W, Rosen MK. A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting. Journal of Molecular Biology. 338: 271-85. PMID 15066431 DOI: 10.1016/J.Jmb.2004.02.036  0.655
2003 Labno CM, Lewis CM, You D, Leung DW, Takesono A, Kamberos N, Seth A, Finkelstein LD, Rosen MK, Schwartzberg PL, Burkhardt JK. Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP Current Biology. 13: 1619-1624. PMID 13678593 DOI: 10.1016/J.Cub.2003.08.005  0.796
2003 Panchal SC, Kaiser DA, Torres E, Pollard TD, Rosen MK. A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex. Nature Structural Biology. 10: 591-8. PMID 12872157 DOI: 10.1038/Nsb952  0.691
2003 Kreishman-Deitrick M, Egile C, Hoyt DW, Ford JJ, Li R, Rosen MK. NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex. Biochemistry. 42: 8579-86. PMID 12859205 DOI: 10.1021/Bi034536J  0.307
2003 Torres E, Rosen MK. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Molecular Cell. 11: 1215-27. PMID 12769846 DOI: 10.1016/S1097-2765(03)00139-4  0.671
2003 Seth A, Otomo T, Yin HL, Rosen MK. Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. Biochemistry. 42: 3997-4008. PMID 12680752 DOI: 10.1021/Bi026881Z  0.779
2003 Garrard SM, Capaldo CT, Gao L, Rosen MK, Macara IG, Tomchick DR. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. The Embo Journal. 22: 1125-33. PMID 12606577 DOI: 10.1093/Emboj/Cdg110  0.42
2002 Chook YM, Jung A, Rosen MK, Blobel G. Uncoupling Kapbeta2 substrate dissociation and ran binding. Biochemistry. 41: 6955-66. PMID 12033928 DOI: 10.1021/Bi012122P  0.669
2002 Kreishman-Deitrick M, Rosen MK, Kreishman-Deltrick M. Ignition of a cellular machine. Nature Cell Biology. 4: E31-3. PMID 11835053 DOI: 10.1038/Ncb0202-E31  0.38
2002 Buck M, Xu W, Rosen MK. Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange. Biochemistry. 40: 14115-22. PMID 11714264 DOI: 10.1021/Bi0157215  0.672
2001 Cannon JL, Labno CM, Bosco G, Seth A, McGavin MH, Siminovitch KA, Rosen MK, Burkhardt JK. Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. Immunity. 15: 249-59. PMID 11520460 DOI: 10.1016/S1074-7613(01)00178-9  0.762
2001 Buck M, Rosen MK. Structural biology. Flipping a switch. Science (New York, N.Y.). 291: 2329-30. PMID 11269305 DOI: 10.1126/Science.1060383  0.598
2001 Devriendt K, Kim AS, Mathijs G, Frints SG, Schwartz M, Van Den Oord JJ, Verhoef GE, Boogaerts MA, Fryns JP, You D, Rosen MK, Vandenberghe P. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nature Genetics. 27: 313-7. PMID 11242115 DOI: 10.1038/85886  0.37
2000 Aghazadeh B, Lowry WE, Huang XY, Rosen MK. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation Cell. 102: 625-633. PMID 11007481 DOI: 10.1016/S0092-8674(00)00085-4  0.381
2000 Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature. 404: 151-8. PMID 10724160 DOI: 10.1038/35004513  0.449
2000 Rosen MK, Amos CD, Wandless TJ. Mechanistic studies of affinity modulation Journal of the American Chemical Society. 122: 11979-11982. DOI: 10.1021/Ja002991M  0.638
1999 Aghazadeh B, Rosen MK. Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices. Chemistry & Biology. 6: R241-6. PMID 10467125 DOI: 10.1016/S1074-5521(99)80108-2  0.331
1999 Abdul-Manan N, Aghazadeh B, Liu GA, Majumdar A, Ouerfelli O, Siminovitch KA, Rosen MK. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature. 399: 379-83. PMID 10360578 DOI: 10.1038/20726  0.421
1998 Aghazadeh B, Zhu K, Kubiseski TJ, Liu GA, Pawson T, Zheng Y, Rosen MK. Structure and mutagenesis of the Dbl homology domain. Nature Structural Biology. 5: 1098-107. PMID 9846881 DOI: 10.1038/4209  0.394
1997 Gosser YQ, Nomanbhoy TK, Aghazadeh B, Manor D, Combs C, Cerione RA, Rosen MK. C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature. 387: 814-9. PMID 9194563 DOI: 10.1038/42961  0.39
1997 Gardner KH, Rosen MK, Kay LE. Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR. Biochemistry. 36: 1389-401. PMID 9063887 DOI: 10.1021/Bi9624806  0.615
1996 Gardner KH, Konrat R, Rosen MK, Kay LE. An (H)C(CO)NH-TOCSY pulse scheme for sequential assignment of protonated methyl groups in otherwise deuterated (15)N, (13)C-labeled proteins. Journal of Biomolecular Nmr. 8: 351-6. PMID 20686885 DOI: 10.1007/Bf00410333  0.589
1996 Rosen MK, Gardner KH, Willis RC, Parris WE, Pawson T, Kay LE. Selective methyl group protonation of perdeuterated proteins. Journal of Molecular Biology. 263: 627-36. PMID 8947563 DOI: 10.1006/Jmbi.1996.0603  0.626
1996 Anafi M, Rosen MK, Gish GD, Kay LE, Pawson T. A potential SH3 domain-binding site in the Crk SH2 domain. The Journal of Biological Chemistry. 271: 21365-74. PMID 8702917 DOI: 10.1074/Jbc.271.35.21365  0.525
1995 Rosen MK, Yamazaki T, Gish GD, Kay CM, Pawson T, Kay LE. Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein. Nature. 374: 477-9. PMID 7700361 DOI: 10.1038/374477A0  0.57
1993 Yu H, Rosen MK, Schreiber SL. 1H and 15N assignments and secondary structure of the Src SH3 domain. Febs Letters. 324: 87-92. PMID 8504863 DOI: 10.1016/0014-5793(93)81538-B  0.459
1993 Yu H, Rosen MK, Saccomano NA, Phillips D, Volkmann RA, Schreiber SL. Sequential assignment and structure determination of spider toxin omega-Aga-IVB. Biochemistry. 32: 13123-9. PMID 8241166 DOI: 10.1021/Bi00211A022  0.468
1993 Rosen MK, Yang D, Martin PK, Schreiber SL. Activation of an inactive immunophilin by mutagenesis Journal of the American Chemical Society. 115: 821-822. DOI: 10.1021/Ja00055A082  0.513
1993 Yang D, Rosen MK, Schreiber SL. A composite FKBP12-FK506 surface that contacts calcineurin Journal of the American Chemical Society. 115: 819-820. DOI: 10.1021/Ja00055A081  0.465
1992 Yu H, Rosen MK, Shin TB, Seidel-Dugan C, Brugge JS, Schreiber SL. Solution structure of the SH3 domain of Src and identification of its ligand-binding site Science. 258: 1665-1668. PMID 1280858 DOI: 10.1126/Science.1280858  0.522
1992 Rosen MK, Belshaw PJ, Alberg DG, Schreiber SL. The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin: an analysis of receptor-ligand-receptor interactions Bioorganic and Medicinal Chemistry Letters. 2: 747-753. DOI: 10.1016/S0960-894X(00)80405-9  0.8
1992 Schreiber SL, Lui J, Albers MW, Rosen MK, Standaert RF, Wandless TJ, Somers PK. Molecular Recognition of Immunophilins and Immunophilin-Ligand Complexes Tetrahedron. 48: 2545-2558. DOI: 10.1016/S0040-4020(01)88520-3  0.769
1992 Rosen MK, Schreiber SL. Natural Products as Probes of Cellular Function: Studies of Immunophilins Angewandte Chemie International Edition in English. 31: 384-400. DOI: 10.1002/Anie.199203841  0.496
1992 Rosen MK, Schreiber SL. Naturstoffe als Sonden zum Studium zellulärer Funktionen – Untersuchungen von Immunophilinen Angewandte Chemie. 104: 413-430. DOI: 10.1002/Ange.19921040406  0.371
1991 Rosen MK, Michnick SW, Karplus M, Schreiber SL. Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. Biochemistry. 30: 4774-89. PMID 1709363 DOI: 10.1021/Bi00233A020  0.482
1991 Michnick SW, Rosen MK, Wandless TJ, Karplus M, Schreiber SL. Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin. Science (New York, N.Y.). 252: 836-9. PMID 1709301 DOI: 10.1126/Science.1709301  0.702
1991 Rosen MK, Michnick SW, Wandless TJ, Schreiber SL. Study of receptor-ligand interactions through receptor labeling and isotope-edited NMR Journal of Organic Chemistry. 56: 6262-6264. DOI: 10.1021/Jo00022A007  0.651
1991 Wandless TJ, Michnick SW, Rosen MK, Karplus M, Schreiber SL. FK506 and rapamycin binding to FKBP: common elements in immunophilin-ligand complexation Journal of the American Chemical Society. 113: 2339-2341. DOI: 10.1021/Ja00006A083  0.677
1990 Rosen MK, Standaert RF, Galat A, Nakatsuka M, Schreiber SL. Inhibition of FKBP rotamase activity by immunosuppressant FK506: Twisted amide surrogate Science. 248: 863-866. PMID 1693013 DOI: 10.1126/Science.1693013  0.689
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