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Chad A. Brautigam - Publications

Biophysics University of Texas Southwestern Medical Center, Dallas, TX, United States 
Molecular Biophysics

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhong X, Su L, Yang Y, Nair-Gill E, Tang M, Anderton P, Li X, Wang J, Zhan X, Tomchick DR, Brautigam CA, Moresco EMY, Choi JH, Beutler B. Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function. Proceedings of the National Academy of Sciences of the United States of America. PMID 32220963 DOI: 10.1073/pnas.2000703117  1
2019 Padavannil A, Sarkar P, Kim SJ, Cagatay T, Jiou J, Brautigam CA, Tomchick DR, Sali A, D'Arcy S, Chook YM. Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. Elife. 8. PMID 30855230 DOI: 10.7554/eLife.43630  1
2017 Bae SJ, Ni L, Osinski A, Tomchick DR, Brautigam CA, Luo X. SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK. Elife. 6. PMID 29063833 DOI: 10.7554/eLife.30278  1
2017 Brautigam CA, Deka RK, Liu WZ, Tomchick DR, Norgard MV. Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum. Protein Science : a Publication of the Protein Society. PMID 28168761 DOI: 10.1002/pro.3133  1
2016 Sivakumar S, Janczyk PŁ, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ. The human Ska complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores. Elife. 5. PMID 26981768 DOI: 10.7554/eLife.12902  1
2016 Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Nature Structural & Molecular Biology. PMID 26950369 DOI: 10.1038/nsmb.3183  1
2015 Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA. On the acquisition and analysis of microscale thermophoresis data. Analytical Biochemistry. PMID 26739938 DOI: 10.1016/j.ab.2015.12.013  1
2015 Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV. Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm. Microbiologyopen. PMID 26626129 DOI: 10.1002/mbo3.306  1
2015 Fung HY, Fu SC, Brautigam CA, Chook YM. Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife. 4. PMID 26349033 DOI: 10.7554/eLife.10034  1
2015 Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, et al. A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. Plos One. 10: e0126420. PMID 25997164 DOI: 10.1371/journal.pone.0126420  1
2015 Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV. Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein. Mbio. 6: e00519-15. PMID 25944861 DOI: 10.1128/mBio.00519-15  1
2015 Chaires JB, Hansen LD, Keller S, Brautigam CA, Zhao H, Schuck P. Biocalorimetry. Methods (San Diego, Calif.). 76: 1-2. PMID 25817327 DOI: 10.1016/j.ymeth.2015.02.001  1
2015 Scheuermann TH, Brautigam CA. High-precision, automated integration of multiple isothermal titration calorimetric thermograms: new features of NITPIC. Methods (San Diego, Calif.). 76: 87-98. PMID 25524420 DOI: 10.1016/j.ymeth.2014.11.024  1
2015 Diaz-Martinez LA, Tian W, Li B, Warrington R, Jia L, Brautigam CA, Luo X, Yu H. The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. The Journal of Biological Chemistry. 290: 2431-43. PMID 25505175 DOI: 10.1074/jbc.M114.616490  1
2015 Joslin SN, Pybus C, Labandeira-Rey M, Evans AS, Attia AS, Brautigam CA, Hansen EJ. A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors. Infection and Immunity. 83: 146-60. PMID 25312959 DOI: 10.1128/IAI.02486-14  1
2015 Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV. Evidence for posttranslational protein flavinylation in the syphilis spirochete treponema pallidum: Structural and biochemical insights from the catalytic core of a periplasmic flavin-trafficking protein Mbio. 6: 1-9. DOI: 10.1128/mBio.00519-15  1
2015 Brautigam CA, Deka RK, Liu WZ, Norgard MV. Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein from Treponema pallidum derived from structural and biophysical analyses Protein Science. 24: 11-19. DOI: 10.1002/pro.2576  1
2014 Ayaz P, Munyoki S, Geyer EA, Piedra FA, Vu ES, Bromberg R, Otwinowski Z, Grishin NV, Brautigam CA, Rice LM. A tethered delivery mechanism explains the catalytic action of a microtubule polymerase. Elife. 3: e03069. PMID 25097237 DOI: 10.7554/eLife.03069  1
2014 Wang W, Joslin SN, Pybus C, Evans AS, Lichaa F, Brautigam CA, Hansen EJ. Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model. Infection and Immunity. 82: 2287-99. PMID 24643539 DOI: 10.1128/IAI.01745-14  1
2014 Ouyang Z, Zhou J, Brautigam CA, Deka R, Norgard MV. Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi. Microbiology (Reading, England). 160: 851-62. PMID 24608174 DOI: 10.1099/mic.0.075655-0  1
2014 Gangaiah D, Labandeira-Rey M, Zhang X, Fortney KR, Ellinger S, Zwickl B, Baker B, Liu Y, Janowicz DM, Katz BP, Brautigam CA, Munson RS, Hansen EJ, Spinola SM. Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase. Mbio. 5: e01081-13. PMID 24520065 DOI: 10.1128/mBio.01081-13  1
2014 Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Chen ZJ. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop Cell Reports. 6: 421-430. PMID 24462292 DOI: 10.1016/j.celrep.2014.01.003  1
2014 Brautigam CA, Ouyang Z, Deka RK, Norgard MV. Sequence, biophysical, and structural analyses of the PstS lipoprotein (BB0215) from Borrelia burgdorferi reveal a likely binding component of an ABC-type phosphate transporter. Protein Science : a Publication of the Protein Society. 23: 200-12. PMID 24318969 DOI: 10.1002/pro.2406  1
2014 Ghirlando R, Zhao H, Balbo A, Piszczek G, Curth U, Brautigam CA, Schuck P. Measurement of the temperature of the resting rotor in analytical ultracentrifugation Analytical Biochemistry. 458: 49-57. DOI: 10.1016/j.ab.2014.04.029  1
2013 Labandeira-Rey M, Dodd DA, Brautigam CA, Fortney KR, Spinola SM, Hansen EJ. The Haemophilus ducreyi Fis protein is involved in controlling expression of the lspB-lspA2 operon and other virulence factors. Infection and Immunity. 81: 4160-70. PMID 23980107 DOI: 10.1128/IAI.00714-13  1
2013 Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D, Luo X. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure (London, England : 1993). 21: 1757-68. PMID 23972470 DOI: 10.1016/j.str.2013.07.008  1
2013 Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H. Structure of the human cohesin inhibitor Wapl. Proceedings of the National Academy of Sciences of the United States of America. 110: 11355-60. PMID 23776203 DOI: 10.1073/pnas.1304594110  1
2013 Ghirlando R, Balbo A, Piszczek G, Brown PH, Lewis MS, Brautigam CA, Schuck P, Zhao H. Improving the thermal, radial, and temporal accuracy of the analytical ultracentrifuge through external references Analytical Biochemistry. 440: 81-95. PMID 23711724 DOI: 10.1016/j.ab.2013.05.011  1
2013 Brautigam CA, Padrick SB, Schuck P. Multi-signal sedimentation velocity analysis with mass conservation for determining the stoichiometry of protein complexes. Plos One. 8: e62694. PMID 23696787 DOI: 10.1371/journal.pone.0062694  1
2013 Brautigam CA, Deka RK, Norgard MV. Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69: 453-455. PMID 23545658 DOI: 10.1107/S1744309113006246  1
2013 Zhao H, Ghirlando R, Piszczek G, Curth U, Brautigam CA, Schuck P. Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation Analytical Biochemistry. 437: 104-108. PMID 23458356 DOI: 10.1016/j.ab.2013.02.011  1
2013 Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV. The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis Journal of Biological Chemistry. 288: 11106-11121. PMID 23447540 DOI: 10.1074/jbc.M113.449975  1
2013 Deka RK, Brautigam CA, Biddy BA, Liu WZ, Norgard MV. Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes Mbio. 4: e00615-00612. PMID 23404400 DOI: 10.1128/mBio.00615-12  1
2013 Zhao H, Brautigam CA, Ghirlando R, Schuck P. Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation Current Protocols in Protein Science. PMID 23377850 DOI: 10.1002/0471140864.ps2012s71  1
2013 Velez N, Brautigam CA, Phillips MA. Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme. The Journal of Biological Chemistry. 288: 5232-40. PMID 23288847 DOI: 10.1074/jbc.M112.442475  1
2012 Brautigam CA, Deka RK, Ouyang Z, Machius M, Knutsen G, Tomchick DR, Norgard MV. Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis. Journal of Bacteriology. 194: 6771-81. PMID 23042995 DOI: 10.1128/JB.01494-12  1
2012 Ayaz P, Ye X, Huddleston P, Brautigam CA, Rice LM. A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase. Science (New York, N.Y.). 337: 857-60. PMID 22904013 DOI: 10.1126/science.1221698  1
2012 Jiang X, Kinch LN, Brautigam CA, Chen X, Du F, Grishin NV, Chen ZJ. Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity. 36: 959-73. PMID 22705106 DOI: 10.1016/j.immuni.2012.03.022  1
2012 Keller S, Vargas C, Zhao H, Piszczek G, Brautigam CA, Schuck P. High-precision isothermal titration calorimetry with automated peak-shape analysis Analytical Chemistry. 84: 5066-5073. PMID 22530732 DOI: 10.1021/ac3007522  1
2012 Brautigam CA, Deka RK, Schuck P, Tomchick DR, Norgard MV. Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT) Journal of Molecular Biology. 420: 70-86. PMID 22504226 DOI: 10.1016/j.jmb.2012.04.001  1
2012 Deka RK, Brautigam CA, Goldberg M, Schuck P, Tomchick DR, Norgard MV. Structural, bioinformatic, and in vivo analyses of two treponema pallidum Lipoproteins reveal a unique TRAP transporter Journal of Molecular Biology. 416: 678-696. PMID 22306465 DOI: 10.1016/j.jmb.2012.01.015  1
2012 Wynn RM, Li J, Brautigam CA, Chuang JL, Chuang DT. Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase Journal of Biological Chemistry. 287: 9178-9192. PMID 22291014 DOI: 10.1074/jbc.M111.314963  1
2012 Mendoza JL, Schmidt A, Li Q, Nuvaga E, Barrett T, Bridges RJ, Feranchak AP, Brautigam CA, Thomas PJ. Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences. Cell. 148: 164-74. PMID 22265409 DOI: 10.1016/j.cell.2011.11.023  1
2012 Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK. Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). The Journal of Biological Chemistry. 287: 7357-65. PMID 22253436 DOI: 10.1074/jbc.M111.308684  1
2011 Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK. Mechanism of actin filament nucleation by the bacterial effector VopL. Nature Structural & Molecular Biology. 18: 1068-74. PMID 21873984 DOI: 10.1038/nsmb.2110  1
2011 Brautigam CA, Wynn RM, Chuang JL, Naik MT, Young BB, Huang TH, Chuang DT. Structural and thermodynamic basis for weak interactions between dihydrolipoamide dehydrogenase and subunit-binding domain of the branched-chain α-ketoacid dehydrogenase complex Journal of Biological Chemistry. 286: 23476-23488. PMID 21543315 DOI: 10.1074/jbc.M110.202960  1
2011 Hoopman TC, Liu W, Joslin SN, Pybus C, Brautigam CA, Hansen EJ. Identification of gene products involved in the oxidative stress response of Moraxella catarrhalis. Infection and Immunity. 79: 745-55. PMID 21098105 DOI: 10.1128/IAI.01060-10  1
2010 Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J. Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. Plos One. 5. PMID 20824061 DOI: 10.1371/journal.pone.0012544  1
2010 Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA. Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Analytical Biochemistry. 407: 89-103. PMID 20667444 DOI: 10.1016/j.ab.2010.07.017  1
2010 Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K. Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. The Journal of Biological Chemistry. 285: 20155-63. PMID 20410310 DOI: 10.1074/jbc.M110.114884  1
2009 Brautigam CA, Wakeman CA, Winkler WC. Methods for analysis of ligand-induced RNA conformational changes. Methods in Molecular Biology (Clifton, N.J.). 540: 77-95. PMID 19381554 DOI: 10.1007/978-1-59745-558-9_7  1
2009 Davis L, Abdi K, Machius M, Brautigam C, Tomchick DR, Bennett V, Michaely P. Localization and structure of the ankyrin-binding site on beta2-spectrin. The Journal of Biological Chemistry. 284: 6982-7. PMID 19098307 DOI: 10.1074/jbc.M809245200  1
2008 Attia AS, Sedillo JL, Wang W, Liu W, Brautigam CA, Winkler W, Hansen EJ. Moraxella catarrhalis expresses an unusual Hfq protein Infection and Immunity. 76: 2520-2530. PMID 18362134 DOI: 10.1128/IAI.01652-07  1
2008 Lee J, Tomchick DR, Brautigam CA, Machius M, Kort R, Hellingwerf KJ, Gardner KH. Changes at the KinA PAS-A dimerization interface influence histidine kinase function Biochemistry. 47: 4051-4064. PMID 18324779 DOI: 10.1021/bi7021156  1
2008 Huang N, Sorci L, Zhang X, Brautigam CA, Li X, Raffaelli N, Magni G, Grishin NV, Osterman AL, Zhang H. Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism Structure. 16: 196-209. PMID 18275811 DOI: 10.1016/j.str.2007.11.017  1
2007 Machius M, Brautigam CA, Tomchick DR, Ward P, Otwinowski Z, Blevins JS, Deka RK, Norgard MV. Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. Journal of Molecular Biology. 373: 681-94. PMID 17868688 DOI: 10.1016/j.jmb.2007.08.018  1
2007 Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nature Structural & Molecular Biology. 14: 535-9. PMID 17529991 DOI: 10.1038/nsmb1255  1
2007 Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K. Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases. The Journal of Biological Chemistry. 282: 6773-82. PMID 17204475 DOI: 10.1074/jbc.M608730200  1
2007 Deka RK, Brautigam CA, Tomson FL, Lumpkins SB, Tomchick DR, Machius M, Norgard MV. Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin. The Journal of Biological Chemistry. 282: 5944-58. PMID 17192261 DOI: 10.1074/jbc.M610215200  1
2006 Gilles-Gonzalez MA, Caceres AI, Sousa EH, Tomchick DR, Brautigam C, Gonzalez C, Machius M. A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor. Journal of Molecular Biology. 360: 80-9. PMID 16813836 DOI: 10.1016/j.jmb.2006.04.054  1
2006 Machius M, Wynn RM, Chuang JL, Li J, Kluger R, Yu D, Tomchick DR, Brautigam CA, Chuang DT. A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Structure (London, England : 1993). 14: 287-98. PMID 16472748 DOI: 10.1016/j.str.2006.03.001  1
2006 Brautigam CA, Wynn RM, Chuang JL, Machius M, Tomchick DR, Chuang DT. Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex. Structure (London, England : 1993). 14: 611-21. PMID 16442803 DOI: 10.1016/j.str.2006.01.001  1
2006 Deka RK, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR, Norgard MV. The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum. The Journal of Biological Chemistry. 281: 8072-81. PMID 16418175 DOI: 10.1074/jbc.M511405200  1
2005 Brautigam CA, Chuang JL, Tomchick DR, Machius M, Chuang DT. Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations. Journal of Molecular Biology. 350: 543-52. PMID 15946682 DOI: 10.1016/j.jmb.2005.05.014  1
2005 Thibodeau PH, Brautigam CA, Machius M, Thomas PJ. Side chain and backbone contributions of Phe508 to CFTR folding. Nature Structural & Molecular Biology. 12: 10-6. PMID 15619636 DOI: 10.1038/nsmb881  1
2004 Deka RK, Neil L, Hagman KE, Machius M, Tomchick DR, Brautigam CA, Norgard MV. Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein. The Journal of Biological Chemistry. 279: 55644-50. PMID 15489229 DOI: 10.1074/jbc.M409263200  1
2004 Brautigam CA, Smith BS, Ma Z, Palnitkar M, Tomchick DR, Machius M, Deisenhofer J. Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America. 101: 12142-7. PMID 15299148 DOI: 10.1073/pnas.0404851101  1
2004 Brautigam CA, Chelliah Y, Deisenhofer J. Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I. The Journal of Biological Chemistry. 279: 11948-56. PMID 14688264 DOI: 10.1074/jbc.M312015200  1
1999 Brautigam CA, Aschheim K, Steitz TA. Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment. Chemistry & Biology. 6: 901-8. PMID 10631518 DOI: 10.1016/S1074-5521(00)80009-5  1
1999 Brautigam CA, Sun S, Piccirilli JA, Steitz TA. Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry. 38: 696-704. PMID 9888810 DOI: 10.1021/bi981537g  1
1998 Brautigam CA, Steitz TA. Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Current Opinion in Structural Biology. 8: 54-63. PMID 9519297 DOI: 10.1016/S0959-440X(98)80010-9  1
1998 Brautigam CA, Steitz TA. Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates. Journal of Molecular Biology. 277: 363-77. PMID 9514742 DOI: 10.1006/jmbi.1997.1586  1
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