Theodore Friedmann, M.D. - Publications

Pediatrics University of California, San Diego, La Jolla, CA 
gene therapy, Lesch Nyhan disease

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Year Citation  Score
2015 Kang TH, Friedmann T. Alzheimer's disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch-Nyhan disease). Neuroscience Letters. 590: 35-9. PMID 25636690 DOI: 10.1016/J.Neulet.2015.01.042  0.48
2014 Friedmann T. Gene Therapy for Neurological Disease Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. 95-101. DOI: 10.1016/B978-0-12-410529-4.00008-5  0.48
2013 Kang TH, Park Y, Bader JS, Friedmann T. The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. Plos One. 8: e74967. PMID 24130677 DOI: 10.1371/Journal.Pone.0074967  0.48
2013 Szentirmay AK, Király KP, Lenkey N, Lackó E, Al-Khrasani M, Friedmann T, Timár J, Gyarmati S, Tóth G, Fürst S, Riba P. Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice. Brain Research Bulletin. 90: 66-71. PMID 22995282 DOI: 10.1016/J.Brainresbull.2012.09.006  0.4
2012 Friedmann T, Flenker U, Georgakopoulos C, Alsayrafi M, Sottas PE, Williams SA, Gill RD. Evolving concepts and techniques for anti-doping. Bioanalysis. 4: 1667-80. PMID 22831482 DOI: 10.4155/Bio.12.146  0.48
2012 Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, et al. Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1084-94. PMID 22652996 DOI: 10.1038/Mt.2012.93  0.48
2012 Friedmann T. The successful clinical use of viral vectors for human gene therapy. Preface. Methods in Enzymology. 507: xvii-xx. PMID 22365783 DOI: 10.1016/B978-0-12-386509-0.00027-2  0.48
2012 Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 109: 3377-82. PMID 22331909 DOI: 10.1073/Pnas.1118067109  0.48
2012 Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T. MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Human Molecular Genetics. 21: 609-22. PMID 22042773 DOI: 10.1093/Hmg/Ddr495  0.48
2011 Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, et al. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. Journal of the American College of Cardiology. 58: 1715-27. PMID 21982317 DOI: 10.1016/J.Jacc.2011.07.017  0.48
2011 Kang TH, Guibinga GH, Jinnah HA, Friedmann T. HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? Plos One. 6: e16572. PMID 21305049 DOI: 10.1371/Journal.Pone.0016572  0.48
2011 Sobor M, Timár J, Riba P, Friedmann T, Király KP, Gyarmati S, Al-Khrasani M, Fürst S. Effects of opioid agonist and antagonist in dams exposed to morphine during the perinatal period. Brain Research Bulletin. 84: 53-60. PMID 20934489 DOI: 10.1016/J.Brainresbull.2010.10.001  0.4
2010 Guibinga GH, Friedmann T. Preparation of pseudotyped lentiviral vectors resistant to inactivation by serum complement. Cold Spring Harbor Protocols. 2010: pdb.prot5420. PMID 20647353 DOI: 10.1101/Pdb.Prot5420  0.48
2010 Friedmann T. How close are we to gene doping? The Hastings Center Report. 40: 20-2. PMID 20391845 DOI: 10.1353/Hcr.0.0246  0.48
2010 Friedmann T, Rabin O, Frankel MS. Ethics. Gene doping and sport. Science (New York, N.Y.). 327: 647-8. PMID 20133558 DOI: 10.1126/Science.1177801  0.48
2010 Riba P, Friedmann T, Király KP, Al-Khrasani M, Sobor M, Asim MF, Spetea M, Schmidhammer H, Furst S. Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value. Brain Research Bulletin. 81: 178-84. PMID 19800397 DOI: 10.1016/J.Brainresbull.2009.09.011  0.4
2010 Guibinga GH, Hsu S, Friedmann T. Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 54-62. PMID 19672249 DOI: 10.1038/Mt.2009.178  0.48
2009 King CC, Bouic K, Friedmann T. A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Science. 7: 28. PMID 19664293 DOI: 10.1186/1477-5956-7-28  0.48
2008 Bhasker CR, Friedmann T. Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. Bmc Genomics. 9: 535. PMID 19014463 DOI: 10.1186/1471-2164-9-535  0.48
2008 Guibinga GH, Song S, Loring J, Friedmann T. Characterization of the gene delivery properties of baculoviral-based virosomal vectors. Journal of Virological Methods. 148: 277-82. PMID 18207578 DOI: 10.1016/J.Jviromet.2007.11.007  0.48
2007 Friedmann T. A new serious adverse event in a gene therapy study. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1899-900. PMID 17948042 DOI: 10.1038/Sj.Mt.6300328  0.48
2007 Guo LT, Friedmann T, King CC. Partial characterization of the proteome of the mouse striatum. Proteomics. 7: 3867-9. PMID 17922512 DOI: 10.1002/Pmic.200700163  0.48
2007 Al-Khrasani M, Spetea M, Friedmann T, Riba P, Király K, Schmidhammer H, Furst S. DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens. Brain Research Bulletin. 74: 369-75. PMID 17845912 DOI: 10.1016/J.Brainresbull.2007.07.008  0.4
2007 Friedmann T. A decade of accomplishments: gene therapy and the ASGT. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1576-8. PMID 17710079 DOI: 10.1038/Sj.Mt.6300284  0.48
2007 Song S, Friedmann T. Tissue-specific aberrations of gene expression in HPRT-deficient mice: functional complexity in a monogenic disease? Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1432-43. PMID 17505472 DOI: 10.1038/Sj.Mt.6300199  0.48
2007 Friedmann T. The Evolution of Human Gene Therapy: A Journey from Excessive Hype to Excessive Diffidence to Reality Concepts in Genetic Medicine. 1-6. DOI: 10.1002/9780470184585.ch1  0.48
2006 Friedmann TE, Franzreb M, Thomas ORT. Support particles for magnetic field enhanced separations Aiche Annual Meeting, Conference Proceedings 0.36
2005 Friedmann T. Lessons for the stem cell discourse from the gene therapy experience. Perspectives in Biology and Medicine. 48: 585-91. PMID 16227669 DOI: 10.1353/Pbm.2005.0089  0.48
2005 Guibinga GH, Friedmann T. Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 645-51. PMID 15771967 DOI: 10.1016/J.Ymthe.2004.12.002  0.48
2005 Fürst S, Riba P, Friedmann T, Tímar J, Al-Khrasani M, Obara I, Makuch W, Spetea M, Schütz J, Przewlocki R, Przewlocka B, Schmidhammer H. Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat. The Journal of Pharmacology and Experimental Therapeutics. 312: 609-18. PMID 15383636 DOI: 10.1124/Jpet.104.075176  0.4
2004 Friedmann T. Clinical gene therapy: lessons from the ether dome. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 205-6. PMID 15294165 DOI: 10.1016/J.Ymthe.2004.07.009  0.48
2004 Smith DW, Friedmann T. Discrepant effects of culture conditions on survival and function of dopaminergic neurons. Neuroreport. 15: 1025-8. PMID 15076727 DOI: 10.1097/00001756-200404290-00018  0.48
2004 Guibinga GH, Hall FL, Gordon EM, Ruoslahti E, Friedmann T. Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 76-84. PMID 14741780 DOI: 10.1016/J.Ymthe.2003.09.018  0.48
2004 Spetea M, Friedmann T, Riba P, Schütz J, Wunder G, Langer T, Schmidhammer H, Fürst S. In vitro opioid activity profiles of 6-amino acid substituted derivatives of 14-O-methyloxymorphone. European Journal of Pharmacology. 483: 301-8. PMID 14729121 DOI: 10.1016/J.Ejphar.2003.10.049  0.4
2004 Friedmann T, Lustenberger C, Windhab EJ. Filtration experiments with compressible filter cakes in centrifugal fields with superimposed static pressure International Journal of Mineral Processing. 73: 261-267. DOI: 10.1016/S0301-7516(03)00078-4  0.36
2003 Friedmann T. Gene therapy's new era: a balance of unequivocal benefit and unequivocal harm. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 5-7. PMID 12872762 DOI: 10.1016/S1525-0016(03)00190-4  0.48
2003 Friedmann T. Approaches to gene transfer to the mammalian germ line Designing Our Descendants: the Promises and Perils of Genetic Modifications. 2147483647: 39-54.  0.48
2002 Guibinga GH, Miyanohara A, Esko JD, Friedmann T. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 538-46. PMID 11991744 DOI: 10.1006/Mthe.2002.0578  0.48
2002 Visser JE, Smith DW, Moy SS, Breese GR, Friedmann T, Rothstein JD, Jinnah HA. Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. Brain Research. Developmental Brain Research. 133: 127-39. PMID 11882343 DOI: 10.1016/S0165-3806(02)00280-8  0.48
2002 Aguilar-Cordova CE, Macklin R, Markert ML, Mickelson CA, Ando DG, Breakefield XO, Friedmann TC, Gordon JW, Greenblatt JJ, Juengst ET, King NMP, Levi-Pearl SL. U.S. Department of Health and Human Services National Institutes of Health Recombinant DNA Advisory Committee: Minutes of meeting: December 6, 2001 Human Gene Therapy. 13: 1663-1673. DOI: 10.1089/10430340260201752  0.48
2002 Rupprecht K, Friedmann T, Giefers H, Wortmann G, Doyle B, Zukrowski J. High-pressure/high-temperature NFS study of magnetism in LuFe2 and ScFe2 High Pressure Research. 22: 189-194. DOI: 10.1080/08957950211356  0.36
2002 Friedmann T. Human gene therapy - A new era in medicine Emirates Medical Journal. 20: 107-109.  0.48
2001 Keller K, Friedmann T, Boxman A. The bioseparation needs for tomorrow. Trends in Biotechnology. 19: 438-41. PMID 11602307 DOI: 10.1016/S0167-7799(01)01803-0  0.36
2001 Friedmann T. Stanfield Rogers: insights into virus vectors and failure of an early gene therapy model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 285-8. PMID 11592829 DOI: 10.1006/Mthe.2001.0454  0.48
2001 Okimoto T, Friedmann T, Miyanohara A. VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 232-8. PMID 11545614 DOI: 10.1006/Mthe.2001.0443  0.48
2001 Pacher P, Ungvari Z, Kecskeméti V, Friedmann T, Furst S. Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle. Canadian Journal of Physiology and Pharmacology. 79: 580-4. PMID 11478591 DOI: 10.1139/cjpp-79-7-580  0.4
2001 Friedmann T, Koss JO. Gene transfer and athletics- an impending problem. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 819-20. PMID 11407894 DOI: 10.1006/Mthe.2001.0347  0.48
2001 Friedmann T, Noguchi P, Mickelson C. The evolution of public review and oversight mechanisms in human gene transfer research: joint roles of the FDA and NIH. Current Opinion in Biotechnology. 12: 304-7. PMID 11404110 DOI: 10.1016/S0958-1669(00)00216-0  0.48
2001 Garadnay S, Herczegh P, Makleit S, Friedmann T, Riba P, Fürst S. Reactions of morphine derivatives with phenyliodo(III)diacetate (PIDA): synthesis of new morphine analogues. Current Medicinal Chemistry. 8: 621-6. PMID 11281845 DOI: 10.2174/0929867013373219  0.4
2000 Miyanohara A, Friedmann T. Viral vectors do the DNA shuffle. Nature Biotechnology. 18: 1244-5. PMID 11101799 DOI: 10.1038/82345  0.48
2000 Estuardo Aguilar-Cordova C, Levi-Pearl SL, Macklin R, Markert ML, McIvor RS, Mickelson CA, Wolff JA, Ando DG, Breakefield XO, Chow LT, Friedmann T, Gordon JW, Greenblatt JJ, Juengst ET, King NMP. Department of health and human services national institutes of health recombinant DNA advisory committee: Minutes of meeting March 8-10, 2000 Human Gene Therapy. 11: 2159-2192. PMID 11044916 DOI: 10.1089/104303400750001453  0.48
2000 Sharma S, Miyanohara A, Friedmann T. Separable mechanisms of attachment and cell uptake during retrovirus infection. Journal of Virology. 74: 10790-5. PMID 11044124 DOI: 10.1128/Jvi.74.22.10790-10795.2000  0.48
2000 Smith DW, Friedmann T. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 486-91. PMID 10933970 DOI: 10.1006/Mthe.2000.0057  0.48
2000 Friedmann T. Changing roles for academia and industry in genetics and gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 9-11. PMID 10933906 DOI: 10.1006/Mthe.1999.0015  0.48
2000 Friedmann T. Medical ethics. Principles for human gene therapy studies. Science (New York, N.Y.). 287: 2163-5. PMID 10744537 DOI: 10.1126/Science.287.5461.2163  0.48
1999 Buchschacher GL, Yu L, Murai F, Friedmann T, Miyanohara A. Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. Journal of Virology. 73: 9632-7. PMID 10516075 DOI: 10.1128/Jvi.73.11.9632-9637.1999  0.48
1999 Wojcik BE, Jinnah HA, Muller-Sieburg CE, Friedmann T. Bone marrow transplantation does not ameliorate the neurologic symptoms in mice deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT). Metabolic Brain Disease. 14: 57-65. PMID 10348314 DOI: 10.1023/A:1020661514514  0.48
1999 Jinnah HA, Jones MD, Wojcik BE, Rothstein JD, Hess EJ, Friedmann T, Breese GR. Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease. Journal of Neurochemistry. 72: 225-9. PMID 9886073 DOI: 10.1046/J.1471-4159.1999.0720225.X  0.48
1998 Abe A, Miyanohara A, Friedmann T. Polybrene increases the efficiency of gene transfer by lipofection. Gene Therapy. 5: 708-11. PMID 9797877 DOI: 10.1038/Sj.Gt.3300652  0.48
1998 Johnson LG, Mewshaw JP, Ni H, Friedmann T, Boucher RC, Olsen JC. Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector. Journal of Virology. 72: 8861-72. PMID 9765431 DOI: 10.1128/Jvi.72.11.8861-8872.1998  0.48
1998 Abe A, Chen ST, Miyanohara A, Friedmann T. In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein. Journal of Virology. 72: 6356-61. PMID 9658075 DOI: 10.1128/Jvi.72.8.6356-6361.1998  0.48
1998 Abe A, Miyanohara A, Friedmann T. Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. Journal of Virology. 72: 6159-63. PMID 9621082 DOI: 10.1128/Jvi.72.7.6159-6163.1998  0.48
1998 Friedmann T, Windhab EJ. Determination of filter cake properties by nuclear magnetic resonance Separation Science and Technology. 33: 2221-2239.  0.36
1997 Friedmann T. The road toward human gene therapy--a 25-year perspective. Annals of Medicine. 29: 575-7. PMID 9562527 DOI: 10.3109/07853899709007485  0.48
1997 Sharma S, Murai F, Miyanohara A, Friedmann T. Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents. Proceedings of the National Academy of Sciences of the United States of America. 94: 10803-8. PMID 9380714 DOI: 10.1073/Pnas.94.20.10803  0.48
1997 Takeuchi Y, Liong SH, Bieniasz PD, Jager U, Porter CD, Friedmann T, McClure MO, Weiss RA. Sensitization of rhabdo-, lenti-, and spumaviruses to human serum by galactosyl(α1-3)galactosylation Journal of Virology. 71: 6174-6178. PMID 9223512  0.48
1997 Friedmann T. Overcoming the obstacles to gene therapy. Scientific American. 276: 96-101. PMID 9163941 DOI: 10.1038/Scientificamerican0697-95  0.48
1996 Cantwell MJ, Sharma S, Friedmann T, Kipps TJ. Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood. 88: 4676-83. PMID 8977261 DOI: 10.1182/Blood.V88.12.4676.Bloodjournal88124676  0.48
1996 Friedmann T. The maturation of human gene therapy. Acta Paediatrica (Oslo, Norway : 1992). 85: 1261-5. PMID 8955449 DOI: 10.1111/J.1651-2227.1996.Tb13908.X  0.48
1996 Burns JC, McNeill L, Shimizu C, Matsubara T, Yee JK, Friedmann T, Kurdi-Haidar B, Maliwat E, Holt CE. Retrovirol gene transfer in Xenopus cell lines and embryos. In Vitro Cellular & Developmental Biology. Animal. 32: 78-84. PMID 8907120 DOI: 10.1007/Bf02723038  0.48
1996 Sharma S, Cantwell M, Kipps TJ, Friedmann T. Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector. Proceedings of the National Academy of Sciences of the United States of America. 93: 11842-7. PMID 8876225 DOI: 10.1073/Pnas.93.21.11842  0.48
1996 Douar AM, Themis M, Sandig V, Friedmann T, Coutelle C. Effect of amniotic fluid on cationic lipid mediated transfection and retroviral infection. Gene Therapy. 3: 789-96. PMID 8875227  0.48
1996 Chen ST, Iida A, Guo L, Friedmann T, Yee JK. Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system. Proceedings of the National Academy of Sciences of the United States of America. 93: 10057-62. PMID 8816750 DOI: 10.1073/Pnas.93.19.10057  0.48
1996 Iida A, Chen ST, Friedmann T, Yee JK. Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system. Journal of Virology. 70: 6054-9. PMID 8709228  0.48
1996 Kurdi-Haidar B, Friedmann T. Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Gene. 168: 199-203. PMID 8654944 DOI: 10.1016/0378-1119(95)00753-9  0.48
1996 Friedmann T. Human gene therapy--an immature genie, but certainly out of the bottle. Nature Medicine. 2: 144-7. PMID 8574951 DOI: 10.1038/Nm0296-144  0.48
1996 Windhab EJ, Friedmann T, Mayer G. Zum Durchströmungsverhalten kompressibler Filterkuchen mit nicht-Newtonschen Fluiden bei der drucküberlagerten Zentrifugalentfeuchtung Chemie-Ingenieur-Technik. 68: 701-706.  0.36
1996 Kim SH, Friedmann T. Characterization of the basal and brain-specific expression of the human hypoxanthine guanine phosphoribosyltransferase gene Molecules and Cells. 6: 303-310.  0.48
1995 Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelán I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL. Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. The Journal of Biological Chemistry. 270: 5191-7. PMID 7890629 DOI: 10.1074/Jbc.270.10.5191  0.48
1995 Van Meir EG, Roemer K, Diserens AC, Kikuchi T, Rempel SA, Haas M, Huang HJ, Friedmann T, de Tribolet N, Cavenee WK. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 1008-12. PMID 7862624 DOI: 10.1073/Pnas.92.4.1008  0.48
1995 Jinnah HA, Friedmann T. Gene therapy and the brain. British Medical Bulletin. 51: 138-48. PMID 7767640 DOI: 10.1093/Oxfordjournals.Bmb.A072943  0.48
1995 Roemer K, Johnson PA, Friedmann T. Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Research. 35: 81-9. PMID 7754677 DOI: 10.1016/0168-1702(94)00083-O  0.48
1995 Miyanohara A, Yee JK, Bouic K, LaPorte P, Friedmann T. Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors. Gene Therapy. 2: 138-42. PMID 7719930  0.48
1995 Wang MJ, Friedmann T, Johnson PA. Differentiation of PC12 cells by infection with an HSV-1 vector expressing nerve growth factor. Gene Therapy. 2: 323-35. PMID 7671108  0.48
1995 Friedmann T, Yee JK. Pseudotyped retroviral vectors for studies of human gene therapy. Nature Medicine. 1: 275-7. PMID 7585046 DOI: 10.1038/Nm0395-275  0.48
1995 Friedmann T. Rigor in gene therapy studies. Gene Therapy. 2: 355-6. PMID 7584108  0.48
1994 Friedmann T. Gene therapy for disorders of the CNS. Gene Therapy. 1: S47-8. PMID 8542395  0.48
1994 Van Meir EG, Kikuchi T, Tada M, Li H, Diserens AC, Wojcik BE, Huang HJ, Friedmann T, de Tribolet N, Cavenee WK. Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Research. 54: 649-52. PMID 8306326  0.48
1994 Burns JC, Matsubara T, Lozinski G, Yee JK, Friedmann T, Washabaugh CH, Tsonis PA. Pantropic retroviral vector-mediated gene transfer, integration, and expression in cultured newt limb cells. Developmental Biology. 165: 285-9. PMID 8088445 DOI: 10.1006/Dbio.1994.1253  0.48
1994 Johnson PA, Wang MJ, Friedmann T. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. Journal of Virology. 68: 6347-62. PMID 8083974 DOI: 10.1128/Jvi.68.10.6347-6362.1994  0.48
1994 Runnebaum IB, Yee JK, Kieback DG, Sukumar S, Friedmann T. Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles. Anticancer Research. 14: 1137-44. PMID 8074464  0.48
1994 Friedmann T. Gene therapy for neurological disorders. Trends in Genetics : Tig. 10: 210-4. PMID 8073535 DOI: 10.1016/0168-9525(94)90258-5  0.48
1994 Lin S, Gaiano N, Culp P, Burns JC, Friedmann T, Yee JK, Hopkins N. Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish. Science (New York, N.Y.). 265: 666-9. PMID 8036514 DOI: 10.1126/Science.8036514  0.48
1994 Roemer K, Friedmann T. Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function. Annals of the New York Academy of Sciences. 716: 265-80; discussion 2. PMID 8024199 DOI: 10.1111/J.1749-6632.1994.Tb21718.X  0.48
1994 Yee JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 91: 9564-8. PMID 7937806 DOI: 10.1073/Pnas.91.20.9564  0.48
1994 Yee JK, Friedmann T, Burns JC. Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods in Cell Biology. 43: 99-112. PMID 7823872 DOI: 10.1016/S0091-679X(08)60600-7  0.48
1994 Johnson PA, Friedmann T. Replication-defective recombinant herpes simplex virus vectors. Methods in Cell Biology. 43: 211-30. PMID 7823863 DOI: 10.1016/S0091-679X(08)60605-6  0.48
1994 Friedmann T. The promise and overpromise of human gene therapy. Gene Therapy. 1: 217-8. PMID 7584084  0.48
1994 Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD. High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Human Gene Therapy. 5: 203-8. PMID 7514449 DOI: 10.1089/Hum.1994.5.2-203  0.48
1994 Jinnah HA, Wojcik BE, Hunt M, Narang N, Lee KY, Goldstein M, Wamsley JK, Langlais PJ, Friedmann T. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 1164-75. PMID 7509865 DOI: 10.1523/Jneurosci.14-03-01164.1994  0.48
1993 Jinnah HA, Page T, Friedmann T. Brain purines in a genetic mouse model of Lesch-Nyhan disease Journal of Neurochemistry. 60: 2036-2045. PMID 8492116 DOI: 10.1111/J.1471-4159.1993.Tb03488.X  0.48
1993 Kurdi-Haidar B, Levine F, Roemer K, LaPorte P, Friedmann T. Provirus-anchored long-range (PAL) mapping of mammalian genomes Genomics. 15: 305-310. PMID 8449495 DOI: 10.1006/Geno.1993.1061  0.48
1993 Roemer K, Friedmann T. Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein Proceedings of the National Academy of Sciences of the United States of America. 90: 9252-9256. PMID 8415687 DOI: 10.1073/Pnas.90.20.9252  0.48
1993 Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 8033-7. PMID 8396259 DOI: 10.1073/Pnas.90.17.8033  0.48
1993 Abe A, Takeo T, Emi N, Tanimoto M, Ueda R, Yee JK, Friedmann T, Saito H. Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector Proceedings of the Society For Experimental Biology and Medicine. 203: 354-359. PMID 8390693 DOI: 10.3181/00379727-203-43611  0.48
1993 Levine F, Friedmann T. Gene therapy. American Journal of Diseases of Children (1960). 147: 1167-74. PMID 8237910 DOI: 10.1001/archpedi.1993.02160350041006  0.48
1993 Friedmann T. Milestone and events in the early development of human gene therapy Molecular Genetic Medicine. 3: 1-32. PMID 8220161 DOI: 10.1016/B978-0-12-462003-2.50005-5  0.48
1993 Friedmann T, Jinnah HA. Gene therapy for disorders of the nervous system Trends in Biotechnology. 11: 192-197. PMID 7763810 DOI: 10.1016/0167-7799(93)90113-N  0.48
1993 Friedmann T. Gene therapy - a new kind of medicine Trends in Biotechnology. 11: 156-159. PMID 7763803 DOI: 10.1016/0167-7799(93)90106-J  0.48
1993 Runnebaum IB, Kieback DG, Friedmann T, Sukumar S, Kreienberg R. Mutationen des p53 Tumorsuppressor-Gens beim Mammakarzinom und Suppression des neoplastischen Phänotyps durch Wildtyp p53 Archives of Gynecology and Obstetrics. 254: 834-836. DOI: 10.1007/Bf02266196  0.48
1993 Friedmann T. Progress in gene therapy Clinical Chemistry. 39: 705-706.  0.48
1992 Jinnah HA, Hess EJ, Wilson MC, Gage FH, Friedmann T. Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Molecular and Cellular Neurosciences. 3: 64-78. PMID 19912847 DOI: 10.1016/1044-7431(92)90010-Y  0.48
1992 Roemer K, Friedmann T. Concepts and strategies for human gene therapy European Journal of Biochemistry. 208: 211-225. PMID 1521521 DOI: 10.1111/J.1432-1033.1992.Tb17176.X  0.48
1992 Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somatic Cell and Molecular Genetics. 18: 247-58. PMID 1496420 DOI: 10.1007/Bf01233861  0.48
1992 Roemer K, Johnson PA, Friedmann T. Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome. The Journal of General Virology. 73: 1553-8. PMID 1318949 DOI: 10.1099/0022-1317-73-6-1553  0.48
1992 Friedmann T. A brief history of gene therapy Nature Genetics. 2: 93-98. PMID 1303270 DOI: 10.1038/Ng1092-93  0.48
1991 Emi N, Friedmann T, Yee JK. Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. Journal of Virology. 65: 1202-7. PMID 1847450 DOI: 10.1128/Jvi.65.3.1202-1207.1991  0.48
1991 Jinnah HA, Gage FH, Friedmann T. Amphetamine-Induced Behavioral Phenotype in a Hypoxanthine-Guanine Phosphoribosyltransferase-Deficient Mouse Model of Lesch-Nyhan Syndrome Behavioral Neuroscience. 105: 1004-1012. PMID 1777100 DOI: 10.1037//0735-7044.105.6.1004  0.48
1991 Levine F, Jiing Kuan Yee, Friedmann T. Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector Gene. 108: 167-174. PMID 1660834 DOI: 10.1016/0378-1119(91)90431-A  0.48
1991 Roemer K, Johnson PA, Friedmann T. Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. Journal of Virology. 65: 6900-12. PMID 1658381 DOI: 10.1128/Jvi.65.12.6900-6912.1991  0.48
1991 Levine F, Friedmann T. Gene therapy techniques Current Opinion in Biotechnology. 2: 840-844. PMID 1367958 DOI: 10.1016/S0958-1669(05)80117-X  0.48
1990 Johnson P, Friedmann T. Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene. 88: 207-13. PMID 2347494 DOI: 10.1016/0378-1119(90)90033-N  1
1990 Jinnah HA, Gage FH, Friedmann T. Animal models of Lesch-Nyhan syndrome Brain Research Bulletin. 25: 467-475. PMID 2292045 DOI: 10.1016/0361-9230(90)90239-V  0.48
1990 Short MP, Rosenberg MB, Ezzedine ZD, Gage FH, Friedmann T, Breakefield XO. Autocrine differentiation of PC12 cells mediated by retroviral vectors. Developmental Neuroscience. 12: 34-45. PMID 2105198 DOI: 10.1159/000111833  0.48
1990 Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Progress in Brain Research. 86: 205-17. PMID 2087558 DOI: 10.1016/S0079-6123(08)63178-7  0.48
1989 Wolff JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB, Shimohama S, Friedmann T. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 86: 9011-4. PMID 2573072 DOI: 10.1073/Pnas.86.22.9011  0.48
1989 Xu L, Yee JK, Wolff JA, Friedmann T. Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology. 171: 331-41. PMID 2503932 DOI: 10.1016/0042-6822(89)90600-4  0.48
1989 Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Research. Molecular Brain Research. 5: 271-8. PMID 2501628 DOI: 10.1016/0169-328X(89)90061-2  0.48
1988 Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science (New York, N.Y.). 242: 1563-6. PMID 3201247 DOI: 10.1126/Science.3201247  0.48
1988 Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. Implantation of genetically engineered cells to the brain. Progress in Brain Research. 78: 651-8. PMID 2907815 DOI: 10.1016/S0079-6123(08)60345-3  0.48
1987 Wolff JA, Yee JK, Skelly H, Moores J, Respess J, Friedmann T, Leffert H. Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somatic Cell and Molecular Genetics. 13: 423-8. PMID 3484086 DOI: 10.1007/Bf01534943  0.48
1987 Jolly DJ, Yee JK, Friedmann T. High-efficiency gene transfer into cells. Methods in Enzymology. 149: 10-25. PMID 3480408 DOI: 10.1016/0076-6879(87)49040-X  0.48
1987 Yee JK, Moores JC, Jolly DJ, Wolff JA, Respess JG, Friedmann T. Gene expression from transcriptionally disabled retroviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 84: 5197-201. PMID 3474647 DOI: 10.1073/Pnas.84.15.5197  0.48
1987 Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience. 23: 795-807. PMID 3325854 DOI: 10.1016/0306-4522(87)90159-X  0.48
1987 Wolff JA, Yee JK, Skelly HF, Moores JC, Respess JG, Friedmann T, Leffert H. Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 84: 3344-8. PMID 3033644 DOI: 10.1073/Pnas.84.10.3344  0.48
1987 Yee JK, Jolly DJ, Miller AD, Willis R, Wolff J, Friedmann T. Epitope insertion into the human hypoxanthine phosphoribosyltransferase protein and detection of the mutant protein by an anti-peptide antibody. Gene. 53: 97-104. PMID 2439408 DOI: 10.1016/0378-1119(87)90096-5  0.48
1986 Gruber HE, Finley KD, Luchtman LA, Hershberg RM, Katzman SS, Laikind PK, Meyers EN, Seegmiller JE, Friedmann T, Yee JK. Insertion of hypoxanthine phosphoribosyltransferase cDNA into human bone marrow cells by a retrovirus. Advances in Experimental Medicine and Biology. 195: 171-5. PMID 3014831  0.48
1985 Gruber HE, Finley KD, Hershberg RM, Katzman SS, Laikind PK, Seegmiller JE, Friedmann T, Yee JK, Jolly DJ. Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Science (New York, N.Y.). 230: 1057-61. PMID 3864246 DOI: 10.1126/Science.3864246  0.48
1984 Willis RC, Jolly DJ, Miller AD, Plent MM, Esty AC, Anderson PJ, Chang HC, Jones OW, Seegmiller JE, Friedmann T. Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector. The Journal of Biological Chemistry. 259: 7842-9. PMID 6203897  0.48
1984 Tamashiro JC, Filpula D, Friedmann T, Spector DH. Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA Journal of Virology. 52: 541-548. PMID 6092675 DOI: 10.1128/Jvi.52.2.541-548.1984  0.48
1983 Jolly DJ, Okayama H, Berg P, Esty AC, Filpula D, Bohlen P, Johnson GG, Shively JE, Hunkapillar T, Friedmann T. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase. Proceedings of the National Academy of Sciences of the United States of America. 80: 477-81. PMID 6300847 DOI: 10.1073/Pnas.80.2.477  0.48
1981 Deininger PL, Jolly DJ, Rubin CM, Friedmann T, Schmid CW. Base sequence studies of 300 nucleotide renatured repeated human DNA clones. Journal of Molecular Biology. 151: 17-33. PMID 6276559 DOI: 10.1016/0022-2836(81)90219-9  0.48
1981 Fuhrman SA, Deininger PL, LaPorte P, Friedmann T, Geiduschek EP. Analysis of transcription of the human Alu family ubiquitous repeating element by eukaryotic RNA polymerase III. Nucleic Acids Research. 9: 6439-56. PMID 6275362 DOI: 10.1093/Nar/9.23.6439  0.48
1981 Deininger PL, LaPorte P, Friedmann T. Nucleotide sequence changes in polyoma ts-a mutants: correlation with protein structure. Journal of Virology. 37: 871-5. PMID 6262533 DOI: 10.1128/Jvi.37.3.871-875.1981  0.48
1981 Fujimura FK, Deininger PL, Friedmann T, Linney E. Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells. Cell. 23: 809-14. PMID 6261957 DOI: 10.1016/0092-8674(81)90445-1  0.48
1981 Srivatsan ES, Deininger PL, Friedmann T. Nucleotide sequence at polyoma VP1 mRNA splice sites. Journal of Virology. 37: 244-7. PMID 6260979 DOI: 10.1128/Jvi.37.1.244-247.1981  0.48
1981 Eckhart W, Delbrück S, Deininger P, Friedmann T, Hunter T. A mutation increasing the size of the polyoma virion proteins, VP2 and VP3. Virology. 109: 35-46. PMID 6258312 DOI: 10.1016/0042-6822(81)90469-4  0.48
1980 Hunter T, Hutchinson MA, Eckhart W, Friedmann T, Esty A, La Porte P, Deininger P. Organization of T antigens in the polyoma virus genome. Cold Spring Harbor Symposia On Quantitative Biology. 44: 131-9. PMID 6253126 DOI: 10.1101/Sqb.1980.044.01.015  0.48
1980 Rubin CM, Houck CM, Deininger PL, Friedmann T, Schmid CW. Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences. Nature. 284: 372-4. PMID 6244506 DOI: 10.1038/284372A0  0.48
1979 Hunter T, Hutchinson MA, Eckhart W, Friedmann T, Esty A, LaPorte P, Deininger P. Regions of the polyoma genome coding for T antigens. Nucleic Acids Research. 7: 2275-88. PMID 230465 DOI: 10.1093/Nar/7.8.2275  0.48
1979 Deininger P, Esty A, LaPorte P, Friedmann T. Nucleotide sequence and genetic organization of the polyoma late region: features common to the polyoma early region and SV40. Cell. 18: 771-9. PMID 229965 DOI: 10.1016/0092-8674(79)90130-2  0.48
1979 Friedmann T, Esty A, LaPorte P, Deininger P. The nucleotide sequence and genome organization of the polyoma early region: extensive nucleotide and amino acid homology with SV40. Cell. 17: 715-24. PMID 225042 DOI: 10.1016/0092-8674(79)90278-2  0.48
1978 Air GM, Coulson AR, Fiddes JC, Friedmann T, Hutchison CA, Sanger F, Slocombe PM, Smith AJ. Nucleotide sequence of the F protein coding region of bacteriophage phiX174 and the amino acid sequence of its product. Journal of Molecular Biology. 125: 247-54. PMID 731694 DOI: 10.1016/0022-2836(78)90347-9  0.48
1978 Sanger F, Coulson AR, Friedmann T, Air GM, Barrell BG, Brown NL, Fiddes JC, Hutchison CA, Slocombe PM, Smith M. The nucleotide sequence of bacteriophage phiX174. Journal of Molecular Biology. 125: 225-46. PMID 731693 DOI: 10.1016/0022-2836(78)90346-7  0.48
1975 Friedmann T, Eckhart W. Virion proteins of polyoma temperature-sensitive mutants: late mutants. Cold Spring Harbor Symposia On Quantitative Biology. 39: 243-6. PMID 169065  0.48
1968 FRIEDMANN T, SEEGMILLER JE, SUBAK-SHARPE JH. Metabolic Cooperation between Genetically Marked Human Fibroblasts in Tissue Culture Nature. 220: 272-274. DOI: 10.1038/220272A0  0.32
1967 Friedmann T, Johnson P. The structure of Tamm-Horsfall mucoprotein in fibrocystic disease. The Journal of Laboratory and Clinical Medicine. 70: 404-7. PMID 4962588  1
1966 Friedmann T, Johnson P. Further characterization of the subunit of Tamm-Horsfall mucoprotein. Biochimica Et Biophysica Acta. 130: 355-60. PMID 5972848 DOI: 10.1016/0304-4165(66)90231-5  1
1966 Friedmann T, Johnson P. The disaggregation of Tamm Horsfall mucroprotein by acetic acid. Biochimica Et Biophysica Acta. 121: 292-7. PMID 4960255 DOI: 10.1016/0304-4165(66)90118-8  1
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