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Richard T Premont - Publications

Affiliations: 
1987-1992 Pharmacology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 1992-1999 Medicine/Cardiology Duke University School of Medicine, Durham, NC, United States 
 1999-2018 Medicine/Gastroenterology Duke University School of Medicine, Durham, NC, United States 
 2018- Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Signal Transduction, GPCRs, GTP-binding proteins
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132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gerhards J, Maerz LD, Matthees ESF, Donow C, Moepps B, Premont RT, Burkhalter MD, Hoffmann C, Philipp M. Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development. Journal of the American Society of Nephrology : Jasn. PMID 36810260 DOI: 10.1681/ASN.0000000000000082  0.421
2022 Liu S, Premont RT, Park KH, Rockey DC. β-PIX cooperates with GIT1 to regulate eNOS in sinusoidal endothelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 36044673 DOI: 10.1152/ajpgi.00034.2022  0.573
2020 Liu S, Luttrell LM, Premont RT, Rockey DC. Reply to Schierwagen et al.: β-Arrestins in liver disease. Proceedings of the National Academy of Sciences of the United States of America. 117: 27085-27086. PMID 33144523 DOI: 10.1073/pnas.2014931117  0.557
2020 Premont RT. Keys to the Kingdom: GPCR phosphorylation patterns direct β-arrestin. Embo Reports. 21: e51249. PMID 32840039 DOI: 10.15252/Embr.202051249  0.502
2020 Liu S, Luttrell LM, Premont RT, Rockey DC. β-Arrestin2 is a critical component of the GPCR-eNOS signalosome. Proceedings of the National Academy of Sciences of the United States of America. PMID 32404425 DOI: 10.1073/Pnas.1922608117  0.675
2019 Stomberski CT, Anand P, Venetos NM, Hausladen A, Zhou HL, Premont RT, Stamler JS. AKR1A1 is a novel mammalian S-nitroso-glutathione reductase. The Journal of Biological Chemistry. PMID 31649033 DOI: 10.1074/Jbc.Ra119.011067  0.359
2019 Wang J, Ren XR, Piao H, Zhao S, Osada T, Premont RT, Mook RA, Morse MA, Lyerly HK, Chen W. Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy. The Biochemical Journal. PMID 30635359 DOI: 10.1042/Bcj20180385  0.735
2018 Hendrickx JO, van Gastel J, Leysen H, Santos-Otte P, Premont RT, Martin B, Maudsley S. GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders. Frontiers in Pharmacology. 9: 1484. PMID 30618771 DOI: 10.3389/Fphar.2018.01484  0.616
2018 van Gastel J, Boddaert J, Jushaj A, Premont RT, Luttrell LM, Janssens J, Martin B, Maudsley S. GIT2-a keystone in ageing and age-related disease. Ageing Research Reviews. PMID 29452267 DOI: 10.1016/J.Arr.2018.02.002  0.723
2018 Du K, Hyun J, Premont RT, Choi SS, Michelotti GA, Swiderska-Syn M, Dalton GD, Thelen E, Rizi BS, Jung Y, Diehl AM. Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Hepatic Stellate Cell Activation. Gastroenterology. PMID 29305935 DOI: 10.1053/J.Gastro.2017.12.022  0.302
2017 Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ. β-Arrestin2 mediates progression of murine primary myelofibrosis. Jci Insight. 2. PMID 29263312 DOI: 10.1172/Jci.Insight.98094  0.774
2017 Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W. Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth. Nanoscale. PMID 28828438 DOI: 10.1039/C7Nr01973D  0.704
2017 Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S. Correction for Lu et al., "Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair". Molecular and Cellular Biology. 37. PMID 28801458 DOI: 10.1128/Mcb.00310-17  0.507
2017 Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, et al. Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Aging. PMID 28260693 DOI: 10.18632/aging.101185  0.552
2017 Liu S, Premont RT, Singh S, Rockey DC. Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells. The American Journal of Pathology. PMID 28162981 DOI: 10.1016/J.Ajpath.2016.11.017  0.58
2016 Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ. Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Molecular Psychiatry. PMID 27457813 DOI: 10.1038/Mp.2016.98  0.399
2016 He M, Singh P, Cheng S, Zhang Q, Peng W, Ding X, Li L, Liu J, Premont RT, Morgan D, Burns JM, Swerdlow RH, Suo WZ. GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability. Scientific Reports. 6: 26116. PMID 27193825 DOI: 10.1038/Srep26116  0.33
2016 Zhou W, Li X, Premont RT. Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes. Journal of Cell Science. 129: 1963-74. PMID 27182061 DOI: 10.1242/Jcs.179465  0.4
2016 Swiderska-Syn M, Xie G, Michelotti GA, Jewell ML, Premont RT, Syn WK, Diehl AM. Hedgehog regulates Yes-associated protein 1 in regenerating mouse liver. Hepatology (Baltimore, Md.). PMID 26970079 DOI: 10.1002/Hep.28542  0.302
2016 Black JB, Premont RT, Daaka Y. Feedback Regulation of G Protein-Coupled Receptor Signaling by GRKs and Arrestins. Seminars in Cell & Developmental Biology. PMID 26773211 DOI: 10.1016/J.Semcdb.2015.12.015  0.691
2015 Martin B, Chadwick W, Janssens J, Premont RT, Schmalzigaug R, Becker KG, Lehrmann E, Wood WH, Zhang Y, Siddiqui S, Park SS, Cong WN, Daimon CM, Maudsley S. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Frontiers in Endocrinology. 6: 191. PMID 26834700 DOI: 10.3389/Fendo.2015.00191  0.614
2015 Montesinos MS, Dong W, Goff K, Das B, Guerrero-Given D, Schmalzigaug R, Premont RT, Satterfield R, Kamasawa N, Young SM. Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron. 88: 918-25. PMID 26637799 DOI: 10.1016/J.Neuron.2015.10.042  0.336
2015 Singh MK, Gao H, Sun W, Song Z, Schmalzigaug R, Premont RT, Zhang Q. Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonist. Bioorganic & Medicinal Chemistry Letters. PMID 26152429 DOI: 10.1016/J.Bmcl.2015.06.062  0.345
2015 Gurevich EV, Premont RT, Gainetdinov RR. G protein-coupled receptor kinases: from molecules to diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 361-4. PMID 25649814 DOI: 10.1096/Fj.14-263657Ufm  0.533
2015 Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S. Nuclear GIT2 is an ATM substrate and promotes DNA repair. Molecular and Cellular Biology. 35: 1081-96. PMID 25605334 DOI: 10.1128/Mcb.01432-14  0.589
2015 Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, et al. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut. PMID 25596181 DOI: 10.1136/Gutjnl-2014-308176  0.392
2015 Chen M, Hegde A, Choi YH, Theriot BS, Premont RT, Chen W, Walker JK. Genetic Deletion of β-arrestin-2 Mitigates Established Airway Hyperresponsiveness in a Murine Asthma Model. American Journal of Respiratory Cell and Molecular Biology. PMID 25569510 DOI: 10.1165/Rcmb.2014-0231Oc  0.512
2015 Rein LA, Wisler JW, Theriot BS, Huang L, Premont RT, Lefkowitz RJ. β-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis Blood. 126: 486-486. DOI: 10.1182/Blood.V126.23.486.486  0.75
2014 Liu S, Premont RT, Rockey DC. Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src protein. The Journal of Biological Chemistry. 289: 18163-74. PMID 24764294 DOI: 10.1074/Jbc.M113.521203  0.642
2014 Korthals M, Schilling K, Reichardt P, Mamula D, Schlüter T, Steiner M, Langnäse K, Thomas U, Gundelfinger E, Premont RT, Tedford K, Fischer KD. αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. Journal of Immunology (Baltimore, Md. : 1950). 192: 3228-38. PMID 24591366 DOI: 10.4049/Jimmunol.1302585  0.326
2013 Burkhalter MD, Fralish GB, Premont RT, Caron MG, Philipp M. Grk5l controls heart development by limiting mTOR signaling during symmetry breaking. Cell Reports. 4: 625-32. PMID 23972986 DOI: 10.1016/J.Celrep.2013.07.036  0.619
2013 Xie G, Karaca G, Swiderska-Syn M, Michelotti GA, Krüger L, Chen Y, Premont RT, Choi SS, Diehl AM. Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. Hepatology (Baltimore, Md.). 58: 1801-13. PMID 23703657 DOI: 10.1002/Hep.26511  0.306
2013 Rein LA, Chen M, Theriot BS, Wisler JW, Wingler LM, Premont RT, Chen W, Walker JK, Lefkowitz RJ. Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia Blood. 122: 857-857. DOI: 10.1182/Blood.V122.21.857.857  0.78
2012 Gold JI, Gao E, Shang X, Premont RT, Koch WJ. Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. Circulation Research. 111: 1048-53. PMID 22859683 DOI: 10.1161/Circresaha.112.273367  0.562
2012 Wang X, Liao S, Nelson ER, Schmalzigaug R, Spurney RF, Guilak F, Premont RT, Gesty-Palmer D. The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Biochemical and Biophysical Research Communications. 425: 407-12. PMID 22846567 DOI: 10.1016/J.Bbrc.2012.07.111  0.663
2012 Managò F, Espinoza S, Salahpour A, Sotnikova TD, Caron MG, Premont RT, Gainetdinov RR. The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment. Scientific Reports. 2: 301. PMID 22393477 DOI: 10.1038/Srep00301  0.62
2012 Liu S, Premont RT, Rockey DC. G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis. The Journal of Biological Chemistry. 287: 12309-20. PMID 22294688 DOI: 10.1074/Jbc.M111.320465  0.556
2010 Cheng S, Li L, He S, Liu J, Sun Y, He M, Grasing K, Premont RT, Suo WZ. GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. The Journal of Biological Chemistry. 285: 41541-8. PMID 21041302 DOI: 10.1074/Jbc.M110.170894  0.35
2010 Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, Guy CD, Diehl AM. Signals from dying hepatocytes trigger growth of liver progenitors Gut. 59: 655-665. PMID 20427400 DOI: 10.1136/Gut.2009.204354  0.303
2009 Premont RT, Schmalzigaug R. Metastasis: wherefore arf thou? Current Biology : Cb. 19: R1036-8. PMID 19948141 DOI: 10.1016/J.Cub.2009.10.032  0.319
2009 Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. The Journal of Biological Chemistry. 284: 35040-8. PMID 19801552 DOI: 10.1074/Jbc.M109.047456  0.848
2009 Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM. Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. Drug and Alcohol Dependence. 104: 187-96. PMID 19497686 DOI: 10.1016/J.Drugalcdep.2009.04.011  0.497
2009 Liu J, Rasul I, Sun Y, Wu G, Li L, Premont RT, Suo WZ. GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. The Journal of Biological Chemistry. 284: 19564-71. PMID 19478075 DOI: 10.1074/Jbc.M109.005959  0.359
2009 Schmalzigaug R, Rodriguiz RM, Bonner PE, Davidson CE, Wetsel WC, Premont RT. Impaired fear response in mice lacking GIT1. Neuroscience Letters. 458: 79-83. PMID 19383529 DOI: 10.1016/J.Neulet.2009.04.037  0.404
2009 Schmalzigaug R, Rodriguiz RM, Phillips LE, Davidson CE, Wetsel WC, Premont RT. Anxiety-like behaviors in mice lacking GIT2. Neuroscience Letters. 451: 156-61. PMID 19114090 DOI: 10.1016/J.Neulet.2008.12.034  0.425
2009 Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ. Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis. Molecular Pharmacology. 75: 626-36. PMID 19092051 DOI: 10.1124/Mol.108.050278  0.823
2009 Li L, Rasul I, Liu J, Zhao B, Tang R, Premont RT, Suo WZ. Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice. Brain Research Bulletin. 78: 145-51. PMID 18955119 DOI: 10.1016/J.Brainresbull.2008.09.019  0.332
2008 Kahn RA, Bruford E, Inoue H, Logsdon JM, Nie Z, Premont RT, Randazzo PA, Satake M, Theibert AB, Zapp ML, Cassel D. Consensus nomenclature for the human ArfGAP domain-containing proteins. The Journal of Cell Biology. 182: 1039-44. PMID 18809720 DOI: 10.1083/Jcb.200806041  0.313
2008 Tarrant TK, Rampersad RR, Esserman D, Rothlein LR, Liu P, Premont RT, Lefkowitz RJ, Lee DM, Patel DD. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clinical Immunology (Orlando, Fla.). 129: 115-22. PMID 18662895 DOI: 10.1016/J.Clim.2008.06.008  0.562
2007 Schmalzigaug R, Phee H, Davidson CE, Weiss A, Premont RT. Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 55: 1039-48. PMID 17565117 DOI: 10.1369/Jhc.7A7207.2007  0.391
2007 Schmalzigaug R, Garron ML, Roseman JT, Xing Y, Davidson CE, Arold ST, Premont RT. GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Cellular Signalling. 19: 1733-44. PMID 17467235 DOI: 10.1016/J.Cellsig.2007.03.010  0.382
2007 Premont RT, Gainetdinov RR. Physiological roles of G protein-coupled receptor kinases and arrestins. Annual Review of Physiology. 69: 511-34. PMID 17305472 DOI: 10.1146/Annurev.Physiol.69.022405.154731  0.548
2007 Eijkelkamp N, Heijnen CJ, Lucas A, Premont RT, Elsenbruch S, Schedlowski M, Kavelaars A. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice Gut. 56: 847-854. PMID 17229795 DOI: 10.1136/Gut.2006.107094  0.43
2007 Suo Z, Cox AA, Bartelli N, Rasul I, Festoff BW, Premont RT, Arendash GW. GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment. Neurobiology of Aging. 28: 1873-88. PMID 17011668 DOI: 10.1016/J.Neurobiolaging.2006.08.013  0.395
2006 Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 16284-9. PMID 17060617 DOI: 10.1073/Pnas.0607583103  0.826
2006 Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. The Journal of Biological Chemistry. 281: 37758-72. PMID 17018529 DOI: 10.1074/Jbc.M605756200  0.837
2006 Meyer MZ, Déliot N, Chasserot-Golaz S, Premont RT, Bader MF, Vitale N. Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. The Journal of Biological Chemistry. 281: 7919-26. PMID 16439353 DOI: 10.1074/Jbc.M600081200  0.349
2006 Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. The Journal of Biological Chemistry. 281: 1261-73. PMID 16280323 DOI: 10.1074/Jbc.M506576200  0.834
2005 Luo R, Jacques K, Ahvazi B, Stauffer S, Premont RT, Randazzo PA. Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1. Current Biology : Cb. 15: 2164-9. PMID 16332543 DOI: 10.1016/J.Cub.2005.10.065  0.318
2005 Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nature Medicine. 11: 952-8. PMID 16142243 DOI: 10.1038/Nm1289  0.532
2005 Nie Z, Fei J, Premont RT, Randazzo PA. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. Journal of Cell Science. 118: 3555-66. PMID 16079295 DOI: 10.1242/Jcs.02486  0.363
2005 Premont RT. Once and future signaling: G protein-coupled receptor kinase control of neuronal sensitivity. Neuromolecular Medicine. 7: 129-47. PMID 16052042 DOI: 10.1385/Nmm:7:1-2:129  0.555
2005 Seeman P, Weinshenker D, Quirion R, Srivastava LK, Bhardwaj SK, Grandy DK, Premont RT, Sotnikova TD, Boksa P, El-Ghundi M, O'dowd BF, George SR, Perreault ML, Männistö PT, Robinson S, et al. Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 3513-8. PMID 15716360 DOI: 10.1073/Pnas.0409766102  0.606
2005 Lee SY, Yang JS, Hong W, Premont RT, Hsu VW. ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. The Journal of Cell Biology. 168: 281-90. PMID 15657398 DOI: 10.1083/Jcb.200404008  0.355
2004 Dai J, Li J, Bos E, Porcionatto M, Premont RT, Bourgoin S, Peters PJ, Hsu VW. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. Developmental Cell. 7: 771-6. PMID 15525538 DOI: 10.1016/J.Devcel.2004.10.002  0.35
2004 Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. Desensitization of G protein-coupled receptors and neuronal functions. Annual Review of Neuroscience. 27: 107-44. PMID 15217328 DOI: 10.1146/Annurev.Neuro.27.070203.144206  0.754
2004 Premont RT, Perry SJ, Schmalzigaug R, Roseman JT, Xing Y, Claing A. The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Cellular Signalling. 16: 1001-11. PMID 15212761 DOI: 10.1016/J.Cellsig.2004.02.002  0.715
2004 Audebert S, Navarro C, Nourry C, Chasserot-Golaz S, Lécine P, Bellaiche Y, Dupont JL, Premont RT, Sempéré C, Strub JM, Van Dorsselaer A, Vitale N, Borg JP. Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Current Biology : Cb. 14: 987-95. PMID 15182672 DOI: 10.1016/J.Cub.2004.05.051  0.341
2004 Vroon A, Heijnen CJ, Raatgever R, Touw IP, Ploemacher RE, Premont RT, Kavelaars A. GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo Journal of Leukocyte Biology. 75: 698-704. PMID 14704365 DOI: 10.1189/Jlb.0703320  0.421
2004 Walker JK, Gainetdinov RR, Feldman DS, McFawn PK, Caron MG, Lefkowitz RJ, Premont RT, Fisher JT. G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L312-9. PMID 14565944 DOI: 10.1152/Ajplung.00255.2003  0.741
2003 Kavelaars A, Vroon A, Raatgever RP, Fong AM, Premont RT, Patel DD, Lefkowitz RJ, Heijnen CJ. Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. Journal of Immunology (Baltimore, Md. : 1950). 171: 6128-34. PMID 14634128 DOI: 10.4049/Jimmunol.171.11.6128  0.638
2003 Liu S, Premont RT, Kontos CD, Huang J, Rockey DC. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. The Journal of Biological Chemistry. 278: 49929-35. PMID 14523027 DOI: 10.1074/Jbc.M306930200  0.634
2003 Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. The Journal of Biological Chemistry. 278: 26295-301. PMID 12724327 DOI: 10.1074/Jbc.M212352200  0.83
2003 Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, Macrae AD, Torres GE, Kim KM, Lefkowitz RJ, Caron MG, Premont RT. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron. 38: 291-303. PMID 12718862 DOI: 10.1016/S0896-6273(03)00192-2  0.719
2003 Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. The Journal of Biological Chemistry. 278: 6291-300. PMID 12473661 DOI: 10.1074/Jbc.M212287200  0.447
2003 Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E. Interaction between Liprin-α and GIT1 Is Required for AMPA Receptor Targeting The Journal of Neuroscience. 23: 1667-1677. DOI: 10.1523/Jneurosci.23-05-01667.2003  0.423
2002 Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nature Reviews. Molecular Cell Biology. 3: 639-50. PMID 12209124 DOI: 10.1038/nrm908  0.528
2002 Fong AM, Premont RT, Richardson RM, Yu YR, Lefkowitz RJ, Patel DD. Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 7478-83. PMID 12032308 DOI: 10.1073/Pnas.112198299  0.631
2002 Shetzline MA, Walker JK, Valenzano KJ, Premont RT. Vasoactive intestinal polypeptide type-1 receptor regulation. Desensitization, phosphorylation, and sequestration. The Journal of Biological Chemistry. 277: 25519-26. PMID 11978791 DOI: 10.1074/Jbc.M201815200  0.541
2002 Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ. G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. The Journal of Biological Chemistry. 277: 1607-13. PMID 11700307 DOI: 10.1074/Jbc.M107297200  0.835
2002 Premont RT, Hall RA. Identification of novel G protein-coupled receptor-interacting proteins. Methods in Enzymology. 343: 611-21. PMID 11665595 DOI: 10.1016/S0076-6879(02)43161-8  0.648
2001 Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. The Journal of Biological Chemistry. 276: 42509-13. PMID 11533043 DOI: 10.1074/Jbc.M108399200  0.832
2001 Premont RT, Gainetdinov RR, Caron MG. Following the trace of elusive amines Proceedings of the National Academy of Sciences of the United States of America. 98: 9474-9475. PMID 11504935 DOI: 10.1073/Pnas.181356198  0.596
2001 Premont RT, Vitale N. Purification and characterization of GIT family of ADP-ribosylation factor (ARF) GTPase-activating proteins. Methods in Enzymology. 329: 335-43. PMID 11210553 DOI: 10.1016/S0076-6879(01)29095-8  0.364
2000 Gainetdinov RR, Premont RT, Caron MG, Lefkowitz RJ. Reply: receptor specificity of G-protein-coupled receptor kinases Trends in Pharmacological Sciences. 21: 366-7. PMID 11050311 DOI: 10.1016/S0165-6147(00)01538-8  0.637
2000 Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. The Journal of Biological Chemistry. 275: 22373-80. PMID 10896954 DOI: 10.1074/Jbc.275.29.22373  0.77
2000 Vitale N, Patton WA, Moss J, Vaughan M, Lefkowitz RJ, Premont RT. GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. The Journal of Biological Chemistry. 275: 13901-6. PMID 10788515 DOI: 10.1074/Jbc.275.18.13901  0.568
2000 Claing A, Perry SJ, Achiriloaie M, Walker JK, Albanesi JP, Lefkowitz RJ, Premont RT. Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 97: 1119-24. PMID 10655494 DOI: 10.1073/Pnas.97.3.1119  0.796
2000 Shetzline MA, Walker JK, Curtin BM, Premont RT, Caron MG. G protein-coupled receptor kinase (GRK) specificity of endogenous type 1 vasoactive intestinal polvpeptide (VIP) receptor expressed on the surface of HEK 293 cells Gastroenterology. 118: A309. DOI: 10.1016/S0016-5085(00)83324-7  0.706
1999 Gainetdinov RR, Bohn LM, Walker JK, Laporte SA, Macrae AD, Caron MG, Lefkowitz RJ, Premont RT. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron. 24: 1029-36. PMID 10624964 DOI: 10.1016/S0896-6273(00)81048-X  0.754
1999 Walker JK, Premont RT, Barak LS, Caron MG, Shetzline MA. Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. The Journal of Biological Chemistry. 274: 31515-23. PMID 10531354 DOI: 10.1074/Jbc.274.44.31515  0.728
1999 Premont RT, Macrae AD, Aparicio SA, Kendall HE, Welch JE, Lefkowitz RJ. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. The Journal of Biological Chemistry. 274: 29381-9. PMID 10506199 DOI: 10.1074/Jbc.274.41.29381  0.573
1999 Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, Lefkowitz RJ. G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. The Journal of Biological Chemistry. 274: 24328-34. PMID 10446210 DOI: 10.1074/Jbc.274.34.24328  0.797
1999 Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. The Journal of Biological Chemistry. 274: 22393-400. PMID 10428811 DOI: 10.1074/Jbc.274.32.22393  0.652
1999 Hall RA, Premont RT, Lefkowitz RJ. Heptahelical receptor signaling: beyond the G protein paradigm. The Journal of Cell Biology. 145: 927-32. PMID 10352011 DOI: 10.1083/Jcb.145.5.927  0.669
1999 McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. The Journal of Biological Chemistry. 274: 10677-80. PMID 10196135 DOI: 10.1074/Jbc.274.16.10677  0.823
1998 Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 14082-7. PMID 9826657 DOI: 10.1073/Pnas.95.24.14082  0.858
1998 Stoffel RH, Inglese J, Macrae AD, Lefkowitz RJ, Premont RT. Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. Biochemistry. 37: 16053-9. PMID 9819198 DOI: 10.1021/Bi981432D  0.617
1998 Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ. A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 8496-501. PMID 9671706 DOI: 10.1073/Pnas.95.15.8496  0.819
1998 Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, Lefkowitz RJ. The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature. 392: 626-30. PMID 9560162 DOI: 10.1038/33458  0.817
1998 Shetzline MA, Premont RT, Walker JK, Vigna SR, Caron MG. A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. The Journal of Biological Chemistry. 273: 6756-62. PMID 9506976 DOI: 10.1074/Jbc.273.12.6756  0.734
1998 Shetzline M, Walker J, Premont R, Vigna S, Caron M. Secretin receptor internalization involves a mechanism distinct from clathrin-coated dependent endocytosis Gastroenterology. 114: A1180. DOI: 10.1016/S0016-5085(98)84796-3  0.617
1998 Shetzline M, Vigna S, Caron M, Premont R. Demonstration of secretin receptor phosphorylation using a sensitive and specific receptor antisera Gastroenterology. 114: A1180. DOI: 10.1016/S0016-5085(98)84795-1  0.679
1996 Macrae AD, Premont RT, Jaber M, Peterson AS, Lefkowitz RJ. Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Brain Research. Molecular Brain Research. 42: 245-54. PMID 9013780 DOI: 10.1016/S0169-328X(96)00128-3  0.537
1996 Inglese J, Premont RT. Lipid modifications of G-protein-coupled receptor kinases. Biochemical Society Transactions. 24: 714-7. PMID 8878832 DOI: 10.1042/Bst0240714  0.492
1996 Pitcher JA, Fredericks ZL, Stone WC, Premont RT, Stoffel RH, Koch WJ, Lefkowitz RJ. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. The Journal of Biological Chemistry. 271: 24907-13. PMID 8798768 DOI: 10.1074/Jbc.271.40.24907  0.834
1996 Ménard L, Ferguson SS, Barak LS, Bertrand L, Premont RT, Colapietro AM, Lefkowitz RJ, Caron MG. Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. Biochemistry. 35: 4155-60. PMID 8672451 DOI: 10.1021/Bi952961+  0.766
1996 Premont RT, Matsuoka I, Mattei MG, Pouille Y, Defer N, Hanoune J. Identification and characterization of a widely expressed form of adenylyl cyclase. The Journal of Biological Chemistry. 271: 13900-7. PMID 8662814 DOI: 10.1074/Jbc.271.23.13900  0.358
1996 Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, Inglese J, MacDonald ME, Lefkowitz RJ. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. The Journal of Biological Chemistry. 271: 6403-10. PMID 8626439 DOI: 10.1074/Jbc.271.11.6403  0.778
1995 Palczewski K, Ohguro H, Premont RT, Inglese J. Rhodopsin kinase autophosphorylation. Characterization of site-specific mutations. The Journal of Biological Chemistry. 270: 15294-8. PMID 7797516 DOI: 10.1074/Jbc.270.25.15294  0.335
1995 Premont RT, Inglese J, Lefkowitz RJ. Protein kinases that phosphorylate activated G protein-coupled receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 175-82. PMID 7781920 DOI: 10.1096/Fasebj.9.2.7781920  0.678
1995 Rohlfs EM, Daniel KW, Premont RT, Kozak LP, Collins S. Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. The Journal of Biological Chemistry. 270: 10723-32. PMID 7738011 DOI: 10.1074/Jbc.270.18.10723  0.688
1995 Mons N, Harry A, Dubourg P, Premont RT, Iyengar R, Cooper DM. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proceedings of the National Academy of Sciences of the United States of America. 92: 8473-7. PMID 7667314 DOI: 10.1073/Pnas.92.18.8473  0.527
1994 Premont RT, Koch WJ, Inglese J, Lefkowitz RJ. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. The Journal of Biological Chemistry. 269: 6832-41. PMID 8120045  0.511
1994 Stoffel RH, Randall RR, Premont RT, Lefkowitz RJ, Inglese J. Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. The Journal of Biological Chemistry. 269: 27791-4. PMID 7961702  0.397
1994 Ma HW, Iyengar R, Premont RT. Amplification of phosphatidylinositol-specific phospholipase C-beta isoforms using degenerate primers. Methods in Enzymology. 238: 244-52. PMID 7799790 DOI: 10.1016/0076-6879(94)38022-8  0.533
1993 Pieroni JP, Miller D, Premont RT, Iyengar R. Type 5 adenylyl cyclase distribution. Nature. 363: 679-80. PMID 8515810 DOI: 10.1038/363679A0  0.437
1993 Jacobowitz O, Chen J, Premont RT, Iyengar R. Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment. The Journal of Biological Chemistry. 268: 3829-32. PMID 8440678  0.476
1993 Ma HW, Blitzer RD, Healy EC, Premont RT, Landau EM, Iyengar R. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. The Journal of Biological Chemistry. 268: 19915-8. PMID 8397190  0.557
1993 Blitzer RD, Omri G, De Vivo M, Carty DJ, Premont RT, Codina J, Birnbaumer L, Cotecchia S, Caron MG, Lefkowitz RJ. Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. The Journal of Biological Chemistry. 268: 7532-7. PMID 8385110  0.462
1993 Lefkowitz RJ, Premont RT. Diseased G protein-coupled receptors. The Journal of Clinical Investigation. 92: 2089. PMID 8227321 DOI: 10.1172/Jci116806  0.581
1993 Premont RT, Chen J, Jacobowitz O, Iyengar R. Molecular Diversity of Mammalian Adenylyl Cyclases: Functional Consequences Handbook of Experimental Pharmacology. 108: 189-212. DOI: 10.1007/978-3-642-78345-6_12  0.304
1992 Kroll SD, Chen J, De Vivo M, Carty DJ, Buku A, Premont RT, Iyengar R. The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation. The Journal of Biological Chemistry. 267: 23183-8. PMID 1429665  0.437
1992 Premont RT, Chen J, Ma HW, Ponnapalli M, Iyengar R. Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proceedings of the National Academy of Sciences of the United States of America. 89: 9809-13. PMID 1409703 DOI: 10.1073/Pnas.89.20.9809  0.565
1992 Premont RT, Jacobowitz O, Iyengar R. Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation. Endocrinology. 131: 2774-84. PMID 1332848 DOI: 10.1210/Endo.131.6.1332848  0.582
1991 Carty DJ, Premont RT, Iyengar R. Quantitative immunoblotting of G-protein subunits. Methods in Enzymology. 195: 302-15. PMID 1903493 DOI: 10.1016/0076-6879(91)95175-J  0.554
1989 Premont RT, Buku A, Iyengar R. The G alpha z gene product in human erythrocytes. Identification as a 41-kilodalton protein. The Journal of Biological Chemistry. 264: 14960-4. PMID 2504714  0.412
1989 Premont RT, Iyengar R. Heterologous desensitization of the liver adenylyl cyclase: analysis of the role of G-proteins. Endocrinology. 125: 1151-60. PMID 2503363 DOI: 10.1210/Endo-125-3-1151  0.601
1988 Premont RT, Iyengar R. Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways. The Journal of Biological Chemistry. 263: 16087-95. PMID 2846535  0.575
1988 Iyengar R, Rich KA, Herberg JT, Premont RT, Codina J. Glucagon receptor-mediated activation of Gs is accompanied by subunit dissociation. The Journal of Biological Chemistry. 263: 15348-53. PMID 2844810  0.506
1988 Moriarty TM, Gillo B, Carty DJ, Premont RT, Landau EM, Iyengar R. Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C. Proceedings of the National Academy of Sciences of the United States of America. 85: 8865-9. PMID 2461557 DOI: 10.1073/Pnas.85.23.8865  0.642
1987 Padrell E, Herberg JT, Monsatirsky B, Floyd G, Premont RT, Iyengar R. The hepatic glucagon receptor: a comparative study of the regulatory and structural properties. Endocrinology. 120: 2316-25. PMID 3032585 DOI: 10.1210/Endo-120-6-2316  0.503
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