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Charles Askew, PhD - Publications

Affiliations: 
2008-2015 Neuroscience University of Virginia, Charlottesville, VA 
 2011-2015 Otolaryngology Harvard - Boston Children's Hospital 
 2015- Gene Therapy Center University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Sensory Neuroscience
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16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Casey G, Askew C, Brimble MA, Samulski RJ, Davidoff AM, Li C, Walters BJ. Self-complementarity in adeno-associated virus enhances transduction and gene expression in mouse cochlear tissues. Plos One. 15: e0242599. PMID 33227033 DOI: 10.1371/journal.pone.0242599  0.32
2020 Pei X, Shao W, Xing A, Askew C, Chen X, Cui C, Abajas YL, Gerber DA, Merricks EP, Nichols TC, Li W, Samulski RJ, Li C. Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity. Molecular Therapy. Methods & Clinical Development. 18: 259-268. PMID 32637455 DOI: 10.1016/J.Omtm.2020.06.003  0.394
2020 Askew C, Chien WW. Adeno-associated virus gene replacement for recessive inner ear dysfunction: Progress and challenges. Hearing Research. 107947. PMID 32247629 DOI: 10.1016/J.Heares.2020.107947  0.537
2020 Pei X, Shao W, Xing A, Askew C, Chen X, Cui C, Abajas YL, Gerber DA, Merricks EP, Nichols TC, Li W, Samulski RJ, Li C. Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity Molecular Therapy - Methods & Clinical Development. 18: 259-268. DOI: 10.1016/j.omtm.2020.06.003  0.399
2019 Shao W, Pei X, Cui C, Askew C, Dobbins A, Chen X, Abajas YL, Gerber DA, Samulski RJ, Nichols TC, Li C. Superior human hepatocyte transduction with adeno-associated virus vector serotype 7. Gene Therapy. PMID 31570819 DOI: 10.1038/S41434-019-0104-5  0.528
2019 Pappa AK, Hutson KA, Scott WC, Wilson JD, Fox KE, Masood MM, Giardina CK, Pulver SH, Grana GD, Askew C, Fitzpatrick DC. Hair Cell and Neural Contributions to the Cochlear Summating Potential. Journal of Neurophysiology. PMID 30943095 DOI: 10.1152/Jn.00006.2019  0.366
2018 Avenarius MR, Jung JY, Askew C, Jones SM, Hunker KL, Azaiez H, Rehman AU, Schraders M, Najmabadi H, Kremer H, Smith RJH, Géléoc GSG, Dolan DF, Raphael Y, Kohrman DC. Grxcr2 is required for stereocilia morphogenesis in the cochlea. Plos One. 13: e0201713. PMID 30157177 DOI: 10.1371/Journal.Pone.0201713  0.547
2017 Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS. Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nature Biotechnology. PMID 28165476 DOI: 10.1038/Nbt.3801  0.704
2017 Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nature Biotechnology. PMID 28165475 DOI: 10.1038/Nbt.3781  0.683
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice. Science Translational Medicine. 7: 295ra108. PMID 26157030 DOI: 10.1126/Scitranslmed.Aab1996  0.723
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab1996  0.638
2014 Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J. Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Human Molecular Genetics. 23: 2374-90. PMID 24334608 DOI: 10.1093/Hmg/Ddt629  0.726
2012 Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9485-98. PMID 22787034 DOI: 10.1523/Jneurosci.0311-12.2012  0.582
2011 Collado MS, Thiede BR, Baker W, Askew C, Igbani LM, Corwin JT. The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11855-66. PMID 21849546 DOI: 10.1523/Jneurosci.2525-11.2011  0.432
2009 Zallocchi M, Meehan DT, Delimont D, Askew C, Garige S, Gratton MA, Rothermund-Franklin CA, Cosgrove D. Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors. Hearing Research. 255: 109-20. PMID 19539019 DOI: 10.1016/j.heares.2009.06.006  0.639
2005 Gratton MA, Rao VH, Meehan DT, Askew C, Cosgrove D. Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology. The American Journal of Pathology. 166: 1465-74. PMID 15855646 DOI: 10.1016/S0002-9440(10)62363-2  0.568
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