Elizabeth Ann Winzeler, Ph.D. - Publications

1999-2012 Cell Biology Genomics Institute of the Novartis Research Foundation 
 2000-2012 Cell Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2012- Pediatrics University of California, San Diego, La Jolla, CA 
microbiology, chemistry, genetics, genomics, bioinformatics

176 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Abraham M, Gagaring K, Marino ML, Vanaerschot M, Plouffe D, Calla J, Godinez Macias K, Du A, Wree M, Antonova-Koch Y, Eribez K, Luth MR, Ottilie S, Fidock DA, McNamara C, ... Winzeler EA, et al. Probing the Open Global Health Chemical Diversity Library for multistage-active starting points for next-generation antimalarials. Acs Infectious Diseases. PMID 32078764 DOI: 10.1021/acsinfecdis.9b00482  1
2020 Singh S, El-Sakkary N, Skinner DE, Sharma PP, Ottilie S, Antonova-Koch Y, Kumar P, Winzeler E, Poonam, R Caffrey C, Rathi B. Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty. Pharmaceuticals (Basel, Switzerland). 13. PMID 32028743 DOI: 10.3390/ph13020025  1
2019 Skinner-Adams TS, Fisher GM, Riches AG, Hutt OE, Jarvis KE, Wilson T, von Itzstein M, Chopra P, Antonova-Koch Y, Meister S, Winzeler EA, Clarke M, Fidock DA, Burrows JN, Ryan JH, et al. Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. Communications Biology. 2: 166. PMID 31925039 DOI: 10.1038/s42003-019-0397-3  1
2019 Murithi JM, Owen ES, Istvan ES, Lee MCS, Ottilie S, Chibale K, Goldberg DE, Winzeler EA, Llinás M, Fidock DA, Vanaerschot M. Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery. Cell Chemical Biology. PMID 31813848 DOI: 10.1016/j.chembiol.2019.11.009  1
2019 Rosenberg A, Luth MR, Winzeler EA, Behnke M, Sibley LD. Evolution of resistance in vitro reveals mechanisms of artemisinin activity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31806760 DOI: 10.1073/pnas.1914732116  1
2019 Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science Translational Medicine. 11. PMID 31801884 DOI: 10.1126/scitranslmed.aav1636  1
2019 Cowell AN, Winzeler EA. Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections. Genome Medicine. 11: 63. PMID 31640748 DOI: 10.1186/s13073-019-0673-3  1
2019 Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, ... ... Winzeler EA, et al. Validation of the protein kinase CLK3 as a multistage cross-species malarial drug target. Science (New York, N.Y.). 365. PMID 31467193 DOI: 10.1126/science.aau1682  1
2019 Norcross NR, Wilson C, Baragaña B, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Fletcher D, Sinden R, Delves M, Ruecker A, Duffy S, Meister S, Antonova-Koch Y, Crespo B, ... ... Winzeler EA, et al. Substituted aminoacetamides as novel leads for malaria. Chemmedchem. PMID 31188540 DOI: 10.1002/cmdc.201900329  1
2019 Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA. Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. Plos Pathogens. 15: e1007722. PMID 31170268 DOI: 10.1371/journal.ppat.1007722  1
2019 Cowell AN, Winzeler EA. The genomic architecture of antimalarial drug resistance. Briefings in Functional Genomics. PMID 31119263 DOI: 10.1093/bfgp/elz008  1
2019 Winzeler EA, Ottilie S. The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa. Proceedings of the National Academy of Sciences of the United States of America. 116: 10198-10200. PMID 31085658 DOI: 10.1073/pnas.1904694116  1
2019 Skinner-Adams TS, Fisher GM, Riches AG, Hutt OE, Jarvis KE, Wilson T, von Itzstein M, Chopra P, Antonova-Koch Y, Meister S, Winzeler EA, Clarke M, Fidock DA, Burrows JN, Ryan JH, et al. Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. Communications Biology. 2: 166. PMID 31069275 DOI: 10.1038/s42003-019-0397-3  1
2019 Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, ... ... Winzeler EA, et al. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30894487 DOI: 10.1073/pnas.1814685116  1
2019 Istvan E, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE. Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Elife. 8. PMID 30888318 DOI: 10.7554/eLife.40529  1
2019 LaMonte GM, Orjuela-Sanchez P, Calla J, Wang LT, Li S, Swann J, Cowell AN, Zou BY, Abdel-Haleem Mohamed AM, Villa Galarce ZH, Moreno M, Tong Rios C, Vinetz JM, Lewis N, Winzeler EA. Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection. Nature Communications. 10: 488. PMID 30700707 DOI: 10.1038/s41467-019-08349-0  1
2019 Mackwitz MKW, Hesping E, Antonova-Koch Y, Diedrich D, Gebru T, Skinner-Adams T, Clarke M, Schöler A, Limbach L, Kurz T, Winzeler EA, Held J, Andrews K, Hansen FK. Structure-Activity and Structure-Toxicity Relationships of Novel Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity. Chemmedchem. PMID 30664827 DOI: 10.1002/cmdc.201800808  1
2019 Fagundez C, Sellanes D, Peña S, Scarone L, Aguiar ACC, de Souza JO, Guido RVC, Stewart L, Yardley V, Ottilie S, Winzeler EA, Gamo FJ, Sanz LM, Serra GL. Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing -Methyl Amino Acids as Antiplasmodial Agents. Acs Medicinal Chemistry Letters. 10: 137-141. PMID 30655961 DOI: 10.1021/acsmedchemlett.8b00543  1
2019 Leven M, Held J, Duffy S, Alves Avelar LA, Meister S, Delves M, Plouffe D, Kuna K, Tschan S, Avery VM, Winzeler EA, Mordmüller B, Kurz T. 8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity. Chemmedchem. PMID 30605243 DOI: 10.1002/cmdc.201800691  1
2019 Winzeler EA. An improbable journey: Creativity helped me make the transition from art to curing malaria. The Journal of Biological Chemistry. 294: 405-409. PMID 30401750 DOI: 10.1074/jbc.AW118.005229  0.01
2018 Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado Rodriguez JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, ... ... Winzeler EA, et al. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.). 362. PMID 30523084 DOI: 10.1126/science.aat9446  1
2018 Cowell A, Winzeler E. Exploration of the Resistome and Druggable Genome Reveals New Mechanisms of Drug Resistance and Antimalarial Targets. Microbiology Insights. 11: 1178636118808529. PMID 30505148 DOI: 10.1177/1178636118808529  0.04
2018 Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould A, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, ... ... Winzeler EA, et al. Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. Journal of Medicinal Chemistry. PMID 30373366 DOI: 10.1021/acs.jmedchem.8b01161  1
2018 Diedrich D, Stenzel K, Hesping E, Antonova-Koch Y, Gebru T, Duffy S, Fisher G, Schöler A, Meister S, Kurz T, Avery VM, Winzeler EA, Held J, Andrews KT, Hansen FK. One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. European Journal of Medicinal Chemistry. 158: 801-813. PMID 30245402 DOI: 10.1016/j.ejmech.2018.09.018  1
2018 Delves MJ, Miguel-Blanco C, Matthews H, Molina I, Ruecker A, Yahiya S, Straschil U, Abraham M, León ML, Fischer OJ, Rueda-Zubiaurre A, Brandt JR, Cortés Á, Barnard A, Fuchter MJ, ... ... Winzeler EA, et al. A high throughput screen for next-generation leads targeting malaria parasite transmission. Nature Communications. 9: 3805. PMID 30228275 DOI: 10.1038/s41467-018-05777-2  1
2018 Cowell AN, Valdivia HO, Bishop DK, Winzeler EA. Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing. Genome Medicine. 10: 52. PMID 29973248 DOI: 10.1186/s13073-018-0563-0  0.24
2018 Llanos-Cuentas A, Casapia M, Chuquiyauri R, Hinojosa JC, Kerr N, Rosario M, Toovey S, Arch RH, Phillips MA, Rozenberg FD, Bath J, Ng CL, Cowell AN, Winzeler EA, Fidock DA, et al. Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study. The Lancet. Infectious Diseases. PMID 29909069 DOI: 10.1016/S1473-3099(18)30309-8  1
2018 Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, ... ... Winzeler EA, et al. Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell. 173: 443-455.e12. PMID 29576450 DOI: 10.1016/j.cell.2018.02.047  1
2018 Winzeler EA. A Sleeping Area of Malaria Research Awakes. Cell Host & Microbe. 23: 292-295. PMID 29544094 DOI: 10.1016/j.chom.2018.02.008  0.01
2018 Orjuela-Sanchez P, Villa ZH, Moreno M, Tong-Rios C, Meister S, LaMonte GM, Campo B, Vinetz JM, Winzeler EA. Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region. Acs Infectious Diseases. PMID 29542317 DOI: 10.1021/acsinfecdis.7b00198  1
2018 Moreno M, Tong-Rios C, Orjuela-Sanchez P, Carrasco-Escobar G, Campo B, Gamboa D, Winzeler EA, Vinetz JM. Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon. Acs Infectious Diseases. PMID 29465219 DOI: 10.1021/acsinfecdis.7b00195  1
2018 Luth MR, Gupta P, Ottilie S, Winzeler EA. Using in Vitro Evolution and Whole Genome Analysis (IVIEWGA) to discover next generation targets for antimalarial drug discovery. Acs Infectious Diseases. PMID 29451780 DOI: 10.1021/acsinfecdis.7b00276  0.52
2018 Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, ... ... Winzeler EA, et al. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.). 359: 191-199. PMID 29326268 DOI: 10.1126/science.aan4472  1
2017 Rabinovich RN, Drakeley C, Djimde AA, Hall BF, Hay SI, Hemingway J, Kaslow DC, Noor A, Okumu F, Steketee R, Tanner M, Wells TNC, Whittaker MA, Winzeler EA, Wirth DF, et al. malERA: An updated research agenda for malaria elimination and eradication. Plos Medicine. 14: e1002456. PMID 29190300 DOI: 10.1371/journal.pmed.1002456  1
2017 Stenzel K, Chua MJ, Duffy S, Antonova-Koch Y, Meister S, Hamacher A, Kassack MU, Winzeler EA, Avery VM, Kurz T, Andrews KT, Hansen FK. Design and synthesis of terephthalic acid-based histone deacetylase inhibitors with dual stage anti-Plasmodium activity. Chemmedchem. PMID 28812327 DOI: 10.1002/cmdc.201700360  1
2017 Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, ... ... Winzeler EA, et al. Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature Microbiology. PMID 28808258 DOI: 10.1038/s41564-017-0007-4  1
2017 Flannery EL, Chatterjee AK, Winzeler EA. Antimalarial drug discovery - approaches and progress towards new medicines. Nature Reviews. Microbiology. 15: 572. PMID 28736448 DOI: 10.1038/nrmicro.2017.88  1
2017 LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, et al. Development of a potent inhibitor of the Plasmodium proteasome with reduced mammalian toxicity. Journal of Medicinal Chemistry. PMID 28696697 DOI: 10.1021/acs.jmedchem.7b00671  1
2017 Leven M, Knaab TC, Held J, Duffy S, Meister S, Fischli C, Meitzner D, Lehmann U, Lungerich B, Kuna K, Stahlke P, Delves MJ, Buchholz M, Winzeler EA, Avery VM, et al. 3-Hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei-infected mice when administered perorally. Journal of Medicinal Chemistry. PMID 28653845 DOI: 10.1021/acs.jmedchem.7b00140  1
2017 Winzeler EA. Glycophorin alleles link to malaria protection. Science (New York, N.Y.). 356: 1122-1123. PMID 28619899 DOI: 10.1126/science.aan4184  0.01
2017 Dhingra SK, Redhi D, Combrinck JM, Yeo T, Okombo J, Henrich PP, Cowell AN, Gupta P, Stegman ML, Hoke JM, Cooper RA, Winzeler E, Mok S, Egan TJ, Fidock DA. A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine. Mbio. 8. PMID 28487425 DOI: 10.1128/mBio.00303-17  1
2017 Winzeler EA. Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance. Genome Biology. 18: 79. PMID 28454594 DOI: 10.1186/s13059-017-1219-x  0.01
2017 Cowell AN, Loy DE, Sundararaman SA, Valdivia H, Fisch K, Lescano AG, Baldeviano GC, Durand S, Gerbasi V, Sutherland CJ, Nolder D, Vinetz JM, Hahn BH, Winzeler EA. Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples. Mbio. 8. PMID 28174312 DOI: 10.1128/mBio.02257-16  1
2017 Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE. Esterase mutation is a mechanism of resistance to antimalarial compounds. Nature Communications. 8: 14240. PMID 28106035 DOI: 10.1038/ncomms14240  1
2016 Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, ... ... Winzeler EA, et al. Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast. Acs Chemical Biology. PMID 27977118 DOI: 10.1021/acschembio.6b01037  1
2016 Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. Acs Infectious Diseases. 2: 816-826. PMID 27933786 DOI: 10.1021/acsinfecdis.6b00025  1
2016 Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, ... ... Winzeler EA, et al. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. Acs Central Science. 2: 687-701. PMID 27800551 DOI: 10.1021/acscentsci.6b00086  1
2016 Le Manach C, Nchinda AT, Paquet T, Gonzalez Cabrera D, Younis Adam Y, Han Z, Bashyam S, Zabiulla M, Taylor D, Lawrence N, White KL, Charman SA, Waterson D, Witty MJ, Wittlin S, ... ... Winzeler EA, et al. Identification of a potential anti-malarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life-cycle. Journal of Medicinal Chemistry. PMID 27748596 DOI: 10.1021/acs.jmedchem.6b01265  1
2016 Lim MY, LaMonte G, Lee MC, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GM, Ho PC, ... ... Winzeler EA, et al. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nature Microbiology. 1: 16166. PMID 27642791 DOI: 10.1038/nmicrobiol.2016.166  1
2016 Baragaña B, Norcross NR, Wilson C, Porzelle A, Hallyburton I, Grimaldi R, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Wyatt PG, Delves MJ, Meister S, Duffy S, ... ... Winzeler EA, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Journal of Medicinal Chemistry. PMID 27631715 DOI: 10.1021/acs.jmedchem.6b00723  1
2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Winzeler EA, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/nature19804  1
2016 Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Winzeler EA, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/journal.ppat.1005763  1
2016 LaMonte G, Lim MY, Wree M, Reimer C, Nachon M, Corey V, Gedeck P, Plouffe D, Du A, Figueroa N, Yeung B, Bifani P, Winzeler EA. Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance. Mbio. 7. PMID 27381290 DOI: 10.1128/mBio.00696-16  1
2016 Norcross NR, Baragaña B, Wilson C, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Porzelle A, Grimaldi R, Wittlin S, Duffy S, Avery VM, Meister S, ... ... Winzeler EA, et al. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Journal of Medicinal Chemistry. PMID 27314305 DOI: 10.1021/acs.jmedchem.6b00028  1
2016 Corey VC, Lukens AK, Istvan ES, Lee MC, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, ... ... Winzeler EA, et al. A broad analysis of resistance development in the malaria parasite. Nature Communications. 7: 11901. PMID 27301419 DOI: 10.1038/ncomms11901  1
2016 Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Stanhope R, ... ... Winzeler EA, et al. Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Scientific Reports. 6: 27806. PMID 27291296 DOI: 10.1038/srep27806  1
2016 Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, ... ... Winzeler EA, et al. Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. PMID 27281209 DOI: 10.1038/nature18280  1
2016 Swann J, Corey V, Scherer CA, Kato N, Comer E, Maetani M, Antonova-Koch Y, Reimer C, Gagaring K, Ibanez M, Plouffe D, Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, ... ... Winzeler EA, et al. High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria. Acs Infectious Diseases. 2: 281-293. PMID 27275010 DOI: 10.1021/acsinfecdis.5b00143  1
2016 Hovlid ML, Winzeler EA. Phenotypic Screens in Antimalarial Drug Discovery. Trends in Parasitology. 32: 697-707. PMID 27247245 DOI: 10.1016/j.pt.2016.04.014  0.01
2016 Lu HH, Pronin SV, Antonova-Koch Y, Meister S, Winzeler EA, Shenvi RA. Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class. Journal of the American Chemical Society. PMID 27244042 DOI: 10.1021/jacs.6b03899  1
2016 Ng CL, Siciliano G, Lee MC, de Almeida MJ, Corey VC, Bopp SE, Bertuccini L, Wittlin S, Kasdin RG, Le Bihan A, Clozel M, Winzeler EA, Alano P, Fidock DA. CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs. Molecular Microbiology. PMID 27073104 DOI: 10.1111/mmi.13397  1
2016 Lehmann JS, Corey VC, Ricaldi JN, Vinetz JM, Winzeler EA, Matthias MA. Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. The American Journal of Tropical Medicine and Hygiene. 94: 302-13. PMID 26711524 DOI: 10.4269/ajtmh.15-0401  1
2015 Plouffe DM, Wree M, Du AY, Meister S, Li F, Patra K, Lubar A, Okitsu SL, Flannery EL, Kato N, Tanaseichuk O, Comer E, Zhou B, Kuhen K, Zhou Y, ... ... Winzeler EA, et al. High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission. Cell Host & Microbe. PMID 26749441 DOI: 10.1016/j.chom.2015.12.001  1
2015 Flannery EL, Wang T, Akbari A, Corey VC, Gunawan F, Bright AT, Abraham M, Sanchez JF, Santolalla ML, Baldeviano GC, Edgel KA, Rosales LA, Lescano AG, Bafna V, Vinetz JM, ... Winzeler EA, et al. Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes. Acs Infectious Diseases. 1: 367-379. PMID 26719854 DOI: 10.1021/acsinfecdis.5b00049  1
2015 Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick WH. Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry. PMID 26632528 DOI: 10.1016/j.phytochem.2015.11.011  1
2015 Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, ... ... Winzeler EA, et al. A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines. Journal of Medicinal Chemistry. 58: 8713-22. PMID 26502160 DOI: 10.1021/acs.jmedchem.5b01605  1
2015 Swann J, Jamshidi N, Lewis NE, Winzeler EA. Systems analysis of host-parasite interactions. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26306749 DOI: 10.1002/wsbm.1311  1
2015 Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, ... ... Winzeler EA, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 522: 315-20. PMID 26085270 DOI: 10.1038/nature14451  1
2015 Suzuki Y, Assad-Garcia N, Kostylev M, Noskov VN, Wise KS, Karas BJ, Stam J, Montague MG, Hanly TJ, Enriquez NJ, Ramon A, Goldgof GM, Richter RA, Vashee S, Chuang RY, ... Winzeler EA, et al. Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling. Genome Research. 25: 435-44. PMID 25654978 DOI: 10.1101/gr.182477.114  1
2015 Flannery EL, McNamara CW, Kim SW, Kato TS, Li F, Teng CH, Gagaring K, Manary MJ, Barboa R, Meister S, Kuhen K, Vinetz JM, Chatterjee AK, Winzeler EA. Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. Acs Chemical Biology. 10: 413-20. PMID 25322084 DOI: 10.1021/cb500616x  1
2014 Winzeler EA, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biology. 15: 544. PMID 25470531 DOI: 10.1186/s13059-014-0544-6  1
2014 Goel S, Muthusamy A, Miao J, Cui L, Salanti A, Winzeler EA, Gowda DC. Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity. The Journal of Biological Chemistry. 289: 34408-21. PMID 25342752 DOI: 10.1074/jbc.M114.615393  1
2014 Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen KL, ... ... Winzeler EA, et al. Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages. Acs Medicinal Chemistry Letters. 5: 947-50. PMID 25147620 DOI: 10.1021/ml500244m  1
2014 Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, ... ... Winzeler EA, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial Agents and Chemotherapy. 58: 5060-7. PMID 24913172 DOI: 10.1128/AAC.02727-13  1
2014 Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. European Journal of Medicinal Chemistry. 82: 204-13. PMID 24904967 DOI: 10.1016/j.ejmech.2014.05.050  1
2014 Bright AT, Manary MJ, Tewhey R, Arango EM, Wang T, Schork NJ, Yanow SK, Winzeler EA. A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings. Plos Neglected Tropical Diseases. 8: e2882. PMID 24901334 DOI: 10.1371/journal.pntd.0002882  1
2014 Manary MJ, Singhakul SS, Flannery EL, Bopp SE, Corey VC, Bright AT, McNamara CW, Walker JR, Winzeler EA. Identification of pathogen genomic variants through an integrated pipeline. Bmc Bioinformatics. 15: 63. PMID 24589256 DOI: 10.1186/1471-2105-15-63  1
2014 Moreno M, Tong C, Guzmán M, Chuquiyauri R, Llanos-Cuentas A, Rodriguez H, Gamboa D, Meister S, Winzeler EA, Maguina P, Conn JE, Vinetz JM. Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax. The American Journal of Tropical Medicine and Hygiene. 90: 612-6. PMID 24534811 DOI: 10.4269/ajtmh.13-0708  1
2014 Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R, Gagaring K, Borboa R, Chen Z, Kuhen K, ... ... Winzeler EA, et al. KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrobial Agents and Chemotherapy. 58: 1586-95. PMID 24366744 DOI: 10.1128/AAC.01927-13  1
2013 McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, ... ... Winzeler EA, et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 504: 248-253. PMID 24284631 DOI: 10.1038/nature12782  1
2013 Flannery EL, Chatterjee AK, Winzeler EA. Antimalarial drug discovery - approaches and progress towards new medicines. Nature Reviews. Microbiology. 11: 849-62. PMID 24217412 DOI: 10.1038/nrmicro3138  1
2013 Bopp SE, Rodrigo E, González-Páez GE, Frazer M, Barnes SW, Valim C, Watson J, Walker JR, Schmedt C, Winzeler EA. Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malaria Journal. 12: 316. PMID 24025732 DOI: 10.1186/1475-2875-12-316  1
2013 Flannery EL, Fidock DA, Winzeler EA. Using genetic methods to define the targets of compounds with antimalarial activity. Journal of Medicinal Chemistry. 56: 7761-71. PMID 23927658 DOI: 10.1021/jm400325j  1
2013 McCarthy JS, Griffin PM, Sekuloski S, Bright AT, Rockett R, Looke D, Elliott S, Whiley D, Sloots T, Winzeler EA, Trenholme KR. Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. The Journal of Infectious Diseases. 208: 1688-94. PMID 23908484 DOI: 10.1093/infdis/jit394  1
2013 Bright AT, Winzeler EA. Epidemiology: resistance mapping in malaria. Nature. 498: 446-7. PMID 23803843 DOI: 10.1038/498446b  1
2013 Bright AT, Alenazi T, Shokoples S, Tarning J, Paganotti GM, White NJ, Houston S, Winzeler EA, Yanow SK. Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria. Emerging Infectious Diseases. 19: 802-5. PMID 23648098 DOI: 10.3201/eid1905.121852  1
2013 Karas BJ, Jablanovic J, Sun L, Ma L, Goldgof GM, Stam J, Ramon A, Manary MJ, Winzeler EA, Venter JC, Weyman PD, Gibson DG, Glass JI, Hutchison CA, Smith HO, et al. Direct transfer of whole genomes from bacteria to yeast. Nature Methods. 10: 410-2. PMID 23542886 DOI: 10.1038/nmeth.2433  1
2013 Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. A key role for lipoic acid synthesis during Plasmodium liver stage development. Cellular Microbiology. 15: 1585-604. PMID 23490300 DOI: 10.1111/cmi.12137  1
2013 Spillman NJ, Allen RJ, McNamara CW, Yeung BK, Winzeler EA, Diagana TT, Kirk K. Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host & Microbe. 13: 227-37. PMID 23414762 DOI: 10.1016/j.chom.2012.12.006  1
2013 Bopp SE, Manary MJ, Bright AT, Johnston GL, Dharia NV, Luna FL, McCormack S, Plouffe D, McNamara CW, Walker JR, Fidock DA, Denchi EL, Winzeler EA. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. Plos Genetics. 9: e1003293. PMID 23408914 DOI: 10.1371/journal.pgen.1003293  1
2012 Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host & Microbe. 12: 739-50. PMID 23245319 DOI: 10.1016/j.chom.2012.11.004  1
2012 Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proceedings of the National Academy of Sciences of the United States of America. 109: 21486-91. PMID 23236186 DOI: 10.1073/pnas.1216016110  1
2012 Nicolaou KC, Lu M, Totokotsopoulos S, Heretsch P, Giguère D, Sun YP, Sarlah D, Nguyen TH, Wolf IC, Smee DF, Day CW, Bopp S, Winzeler EA. Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. Journal of the American Chemical Society. 134: 17320-32. PMID 22978674 DOI: 10.1021/ja308429f  1
2012 Bright AT, Tewhey R, Abeles S, Chuquiyauri R, Llanos-Cuentas A, Ferreira MU, Schork NJ, Vinetz JM, Winzeler EA. Whole genome sequencing analysis of Plasmodium vivax using whole genome capture. Bmc Genomics. 13: 262. PMID 22721170 DOI: 10.1186/1471-2164-13-262  1
2012 Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S, Plikat U, Hartmann N, Staedtler F, Cotesta S, Schmitt EK, ... ... Winzeler EA, et al. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host & Microbe. 11: 654-63. PMID 22704625 DOI: 10.1016/j.chom.2012.04.015  1
2012 Crabb BS, Beeson JG, Amino R, Ménard R, Waters A, Winzeler EA, Wahlgren M, Fidock DA, Nwaka S. Perspectives: The missing pieces. Nature. 484: S22-3. PMID 22534528 DOI: 10.1038/484S22a  1
2012 Nagle A, Wu T, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Lin X, Caldwell C, Ek J, Skolnik S, Liu F, Wang J, Chang J, ... ... Winzeler EA, et al. Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of Medicinal Chemistry. 55: 4244-73. PMID 22524250 DOI: 10.1021/jm300041e  1
2012 Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler EA, Sinden RE, Leroy D. The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. Plos Medicine. 9: e1001169. PMID 22363211 DOI: 10.1371/journal.pmed.1001169  1
2011 Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, ... ... Winzeler EA, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.). 334: 1372-7. PMID 22096101 DOI: 10.1126/science.1211936  1
2011 Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler EA. A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. Acs Chemical Biology. 6: 1214-22. PMID 21866942 DOI: 10.1021/cb200105d  1
2011 Mishra S, Rai U, Shiratsuchi T, Li X, Vanloubbeeck Y, Cohen J, Nussenzweig RS, Winzeler EA, Tsuji M, Nussenzweig V. Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine. 29: 7335-42. PMID 21807053 DOI: 10.1016/j.vaccine.2011.07.081  1
2011 Bright AT, Winzeler EA. Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum. Bmc Biology. 9: 50. PMID 21771351 DOI: 10.1186/1741-7007-9-50  1
2011 McNamara C, Winzeler EA. Target identification and validation of novel antimalarials. Future Microbiology. 6: 693-704. PMID 21707315 DOI: 10.2217/fmb.11.45  1
2011 Wu T, Nagle A, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Goh A, Lakshminarayana SB, Wu J, Ang HQ, Zeng P, Kang ML, Tan W, ... ... Winzeler E, et al. Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of Medicinal Chemistry. 54: 5116-30. PMID 21644570 DOI: 10.1021/jm2003359  1
2011 Eastman RT, Dharia NV, Winzeler EA, Fidock DA. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy. 55: 3908-16. PMID 21576453 DOI: 10.1128/AAC.01793-10  1
2011 Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. Validation of isoleucine utilization targets in Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America. 108: 1627-32. PMID 21205898 DOI: 10.1073/pnas.1011560108  1
2010 Dharia NV, Bright AT, Westenberger SJ, Barnes SW, Batalov S, Kuhen K, Borboa R, Federe GC, McClean CM, Vinetz JM, Neyra V, Llanos-Cuentas A, Barnwell JW, Walker JR, Winzeler EA. Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. Proceedings of the National Academy of Sciences of the United States of America. 107: 20045-50. PMID 21037109 DOI: 10.1073/pnas.1003776107  1
2010 Dharia NV, Plouffe D, Bopp SE, González-Páez GE, Lucas C, Salas C, Soberon V, Bursulaya B, Kochel TJ, Bacon DJ, Winzeler EA. Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Research. 20: 1534-44. PMID 20829224 DOI: 10.1101/gr.105163.110  1
2010 Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, ... ... Winzeler EA, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science (New York, N.Y.). 329: 1175-80. PMID 20813948 DOI: 10.1126/science.1193225  1
2010 Deng X, Nagle A, Wu T, Sakata T, Henson K, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, et al. Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials. Bioorganic & Medicinal Chemistry Letters. 20: 4027-31. PMID 20610151 DOI: 10.1016/j.bmcl.2010.05.095  1
2010 Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ, Roos DS, Fontoura BM, Ménard R, Winzeler EA, et al. The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. The Journal of Experimental Medicine. 207: 1465-74. PMID 20584882 DOI: 10.1084/jem.20091975  1
2010 Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, ... ... Winzeler EA, et al. Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry. 53: 5155-64. PMID 20568778 DOI: 10.1021/jm100410f  1
2010 Bopp SE, Ramachandran V, Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C, Waters AP, Zhou Y, Wiltshire T, Winzeler EA. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. Plos One. 5: e10903. PMID 20531941 DOI: 10.1371/journal.pone.0010903  1
2010 Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, N.Y.). 328: 910-2. PMID 20466936 DOI: 10.1126/science.1188191  1
2010 Westenberger SJ, McClean CM, Chattopadhyay R, Dharia NV, Carlton JM, Barnwell JW, Collins WE, Hoffman SL, Zhou Y, Vinetz JM, Winzeler EA. A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. Plos Neglected Tropical Diseases. 4: e653. PMID 20386602 DOI: 10.1371/journal.pntd.0000653  1
2010 Dharia NV, Chatterjee A, Winzeler EA. Genomics and systems biology in malaria drug discovery. Current Opinion in Investigational Drugs (London, England : 2000). 11: 131-8. PMID 20112162  1
2009 Westenberger SJ, Cui L, Dharia N, Winzeler E, Cui L. Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes. Bmc Genomics. 10: 610. PMID 20015349 DOI: 10.1186/1471-2164-10-610  1
2009 Wu T, Nagle A, Sakata T, Henson K, Borboa R, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, et al. Cell-based optimization of novel benzamides as potential antimalarial leads. Bioorganic & Medicinal Chemistry Letters. 19: 6970-4. PMID 19879133 DOI: 10.1016/j.bmcl.2009.10.050  1
2009 Winzeler EA. Advances in parasite genomics: from sequences to regulatory networks. Plos Pathogens. 5: e1000649. PMID 19876395 DOI: 10.1371/journal.ppat.1000649  0.01
2009 Wirth D, Daily J, Winzeler E, Mesirov JP, Regev A. In vivo profiles in malaria are consistent with a novel physiological state. Proceedings of the National Academy of Sciences of the United States of America. 106: E70; author reply E7. PMID 19570993 DOI: 10.1073/pnas.0904478106  1
2009 Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biology. 10: R21. PMID 19216790 DOI: 10.1186/gb-2009-10-2-r21  1
2008 Le Roch KG, Johnson JR, Ahiboh H, Chung DW, Prudhomme J, Plouffe D, Henson K, Zhou Y, Witola W, Yates JR, Mamoun CB, Winzeler EA, Vial H. A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. Bmc Genomics. 9: 513. PMID 18973684 DOI: 10.1186/1471-2164-9-513  1
2008 Winzeler EA. Malaria research in the post-genomic era. Nature. 455: 751-6. PMID 18843360 DOI: 10.1038/nature07361  0.01
2008 Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, ... ... Winzeler EA, et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America. 105: 9059-64. PMID 18579783 DOI: 10.1073/pnas.0802982105  1
2008 Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, ... ... Winzeler EA, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nature Chemical Biology. 4: 347-56. PMID 18454143 DOI: 10.1038/nchembio.87  1
2008 Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, ... Winzeler EA, et al. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. Plos One. 3: e1570. PMID 18270564 DOI: 10.1371/journal.pone.0001570  1
2008 Young JA, Johnson JR, Benner C, Yan SF, Chen K, Le Roch KG, Zhou Y, Winzeler EA. In silico discovery of transcription regulatory elements in Plasmodium falciparum. Bmc Genomics. 9: 70. PMID 18257930 DOI: 10.1186/1471-2164-9-70  1
2007 Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, ... ... Winzeler EA, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 450: 1091-5. PMID 18046333 DOI: 10.1038/nature06311  1
2007 Sakata T, Winzeler EA. Genomics, systems biology and drug development for infectious diseases. Molecular Biosystems. 3: 841-8. PMID 18000561 DOI: 10.1039/b703924g  0.01
2007 Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V. Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell. 131: 492-504. PMID 17981117 DOI: 10.1016/j.cell.2007.09.013  1
2007 Kumar KA, Garcia CR, Chandran VR, Van Rooijen N, Zhou Y, Winzeler E, Nussenzweig V. Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity. Molecular and Biochemical Parasitology. 156: 32-40. PMID 17714805 DOI: 10.1016/j.molbiopara.2007.07.004  1
2007 Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. The American Journal of Tropical Medicine and Hygiene. 77: 201-8. PMID 17690387  1
2007 Zhou Y, Zhou B, Chen K, Yan SF, King FJ, Jiang S, Winzeler EA. Large-scale annotation of small-molecule libraries using public databases. Journal of Chemical Information and Modeling. 47: 1386-94. PMID 17608408 DOI: 10.1021/ci700092v  1
2007 Gunasekera AM, Myrick A, Le Roch K, Winzeler E, Wirth DF. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Experimental Parasitology. 117: 87-92. PMID 17475254 DOI: 10.1016/j.exppara.2007.03.001  1
2007 Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Molecular and Biochemical Parasitology. 153: 19-30. PMID 17307259 DOI: 10.1016/j.molbiopara.2007.01.011  1
2006 Kidgell C, Winzeler EA. Using the genome to dissect the molecular basis of drug resistance. Future Microbiology. 1: 185-99. PMID 17661664 DOI: 10.2217/17460913.1.2.185  0.01
2006 Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. A systematic map of genetic variation in Plasmodium falciparum. Plos Pathogens. 2: e57. PMID 16789840 DOI: 10.1371/journal.ppat.0020057  1
2005 Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (New York, N.Y.). 309: 1384-7. PMID 16123303 DOI: 10.1126/science.1115257  1
2005 Young JA, Fivelman QL, Blair PL, de la Vega P, Le Roch KG, Zhou Y, Carucci DJ, Baker DA, Winzeler EA. The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Molecular and Biochemical Parasitology. 143: 67-79. PMID 16005087 DOI: 10.1016/j.molbiopara.2005.05.007  1
2005 Kidgell C, Winzeler EA. Elucidating genetic diversity with oligonucleotide arrays. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 13: 225-35. PMID 15868417 DOI: 10.1007/s10577-005-1503-6  1
2005 Simpson KM, Baum J, Good RT, Winzeler EA, Cowman AF, Speed TP. A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays International Journal For Parasitology. 35: 523-531. PMID 15826644 DOI: 10.1016/j.ijpara.2005.02.010  1
2005 Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. The Journal of Infectious Diseases. 191: 1196-203. PMID 15747257 DOI: 10.1086/428289  1
2005 Young JA, Winzeler EA. Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum. Pharmacogenomics. 6: 17-26. PMID 15723602 DOI: 10.1517/14622416.6.1.17  1
2005 Zhou Y, Young JA, Santrosyan A, Chen K, Yan SF, Winzeler EA. In silico gene function prediction using ontology-based pattern identification. Bioinformatics (Oxford, England). 21: 1237-45. PMID 15531612 DOI: 10.1093/bioinformatics/bti111  1
2004 O'Neill BM, Hanway D, Winzeler EA, Romesberg FE. Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Research. 32: 6519-30. PMID 15598824 DOI: 10.1093/nar/gkh994  1
2004 Le Roch KG, Johnson JR, Florens L, Zhou Y, Santrosyan A, Grainger M, Yan SF, Williamson KC, Holder AA, Carucci DJ, Yates JR, Winzeler EA. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Research. 14: 2308-18. PMID 15520293 DOI: 10.1101/gr.2523904  1
2004 Daily JP, Le Roch KG, Sarr O, Fang X, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptional profiling of Plasmodium falciparum. Malaria Journal. 3: 30. PMID 15296511 DOI: 10.1186/1475-2875-3-30  1
2004 Sam-Yellowe TY, Florens L, Johnson JR, Wang T, Drazba JA, Le Roch KG, Zhou Y, Batalov S, Carucci DJ, Winzeler EA, Yates JR. A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Research. 14: 1052-9. PMID 15140830 DOI: 10.1101/gr.2126104  1
2004 Barrera L, Benner C, Tao YC, Winzeler E, Zhou Y. Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays. Bmc Bioinformatics. 5: 42. PMID 15099405 DOI: 10.1186/1471-2105-5-42  1
2003 Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, Haynes JD, De La Vega P, Holder AA, Batalov S, Carucci DJ, Winzeler EA. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (New York, N.Y.). 301: 1503-8. PMID 12893887 DOI: 10.1126/science.1087025  1
2003 Washburn MP, Koller A, Oshiro G, Ulaszek RR, Plouffe D, Deciu C, Winzeler E, Yates JR. Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 100: 3107-12. PMID 12626741 DOI: 10.1073/pnas.0634629100  1
2003 Borevitz JO, Liang D, Plouffe D, Chang HS, Zhu T, Weigel D, Berry CC, Winzeler E, Chory J. Large-scale identification of single-feature polymorphisms in complex genomes. Genome Research. 13: 513-23. PMID 12618383 DOI: 10.1101/gr.541303  1
2003 Winzeler EA, Castillo-Davis CI, Oshiro G, Liang D, Richards DR, Zhou Y, Hartl DL. Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics. 163: 79-89. PMID 12586698  1
2002 Le Roch KG, Zhou Y, Batalov S, Winzeler EA. Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. The American Journal of Tropical Medicine and Hygiene. 67: 233-43. PMID 12408661  1
2002 Williams RM, Primig M, Washburn BK, Winzeler EA, Bellis M, Sarrauste de Menthiere C, Davis RW, Esposito RE. The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proceedings of the National Academy of Sciences of the United States of America. 99: 13431-6. PMID 12370439 DOI: 10.1073/pnas.202495299  1
2002 Volkman SK, Hartl DL, Wirth DF, Nielsen KM, Choi M, Batalov S, Zhou Y, Plouffe D, Le Roch KG, Abagyan R, Winzeler EA. Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (New York, N.Y.). 298: 216-8. PMID 12364807 DOI: 10.1126/science.1075642  1
2002 Que QQ, Winzeler EA. Large-scale mutagenesis and functional genomics in yeast. Functional & Integrative Genomics. 2: 193-8. PMID 12192592 DOI: 10.1007/s10142-002-0057-3  1
2002 Oshiro G, Wodicka LM, Washburn MP, Yates JR, Lockhart DJ, Winzeler EA. Parallel identification of new genes in Saccharomyces cerevisiae. Genome Research. 12: 1210-20. PMID 12176929 DOI: 10.1101/gr.226802  1
2002 Hanway D, Chin JK, Xia G, Oshiro G, Winzeler EA, Romesberg FE. Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proceedings of the National Academy of Sciences of the United States of America. 99: 10605-10. PMID 12149442 DOI: 10.1073/pnas.152264899  1
2002 Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, ... ... Winzeler EA, et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 418: 387-91. PMID 12140549 DOI: 10.1038/nature00935  1
2002 Hartl DL, Volkman SK, Nielsen KM, Barry AE, Day KP, Wirth DF, Winzeler EA. The paradoxical population genetics of Plasmodium falciparum. Trends in Parasitology. 18: 266-72. PMID 12036741 DOI: 10.1016/S1471-4922(02)02268-7  1
2001 Raghuraman MK, Winzeler EA, Collingwood D, Hunt S, Wodicka L, Conway A, Lockhart DJ, Davis RW, Brewer BJ, Fangman WL. Replication dynamics of the yeast genome. Science (New York, N.Y.). 294: 115-21. PMID 11588253 DOI: 10.1126/science.294.5540.115  1
2000 Primig M, Williams RM, Winzeler EA, Tevzadze GG, Conway AR, Hwang SY, Davis RW, Esposito RE. The core meiotic transcriptome in budding yeasts. Nature Genetics. 26: 415-23. PMID 11101837 DOI: 10.1038/82539  1
2000 Winzeler EA, Liang H, Shoemaker DD, Davis RW. Functional analysis of the yeast genome by precise deletion and parallel phenotypic characterization. Novartis Foundation Symposium. 229: 105-9; discussion 10. PMID 11084935  1
2000 Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature. 405: 827-36. PMID 10866209 DOI: 10.1038/35015701  1
1999 Winzeler EA, Lee B, McCusker JH, Davis RW. Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology. 118: S73-80. PMID 10466139  1
1999 Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (New York, N.Y.). 285: 901-6. PMID 10436161 DOI: 10.1126/science.285.5429.901  1
1999 Winzeler EA, Schena M, Davis RW. Fluorescence-based expression monitoring using microarrays. Methods in Enzymology. 306: 3-18. PMID 10432445  1
1999 Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, Astromoff A, Davis RW. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nature Genetics. 21: 278-83. PMID 10080179 DOI: 10.1038/6791  1
1998 Winzeler EA, Richards DR, Conway AR, Goldstein AL, Kalman S, McCullough MJ, McCusker JH, Stevens DA, Wodicka L, Lockhart DJ, Davis RW. Direct allelic variation scanning of the yeast genome. Science (New York, N.Y.). 281: 1194-7. PMID 9712584  1
1998 Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. A genome-wide transcriptional analysis of the mitotic cell cycle. Molecular Cell. 2: 65-73. PMID 9702192  1
1997 Winzeler EA, Davis RW. Functional analysis of the yeast genome. Current Opinion in Genetics & Development. 7: 771-6. PMID 9468786  1
1997 Winzeler E, Wheeler R, Shapiro L. Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype. Journal of Molecular Biology. 272: 665-76. PMID 9368649 DOI: 10.1006/jmbi.1997.1261  1
1997 Winzeler E, Shapiro L. Translation of the leaderless Caulobacter dnaX mRNA. Journal of Bacteriology. 179: 3981-8. PMID 9190815  1
1996 Winzeler E, Shapiro L. A novel promoter motif for Caulobacter cell cycle-controlled DNA replication genes. Journal of Molecular Biology. 264: 412-25. PMID 8969294 DOI: 10.1006/jmbi.1996.0650  1
1995 Winzeler E, Shapiro L. Use of flow cytometry to identify a Caulobacter 4.5 S RNA temperature-sensitive mutant defective in the cell cycle. Journal of Molecular Biology. 251: 346-65. PMID 7544413 DOI: 10.1006/jmbi.1995.0439  1
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