| Year |
Citation |
Score |
| 2020 |
Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, ... ... Ottilie S, et al. Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. Cell Chemical Biology. PMID 32359426 DOI: 10.1016/J.Chembiol.2020.04.001 |
0.425 |
|
| 2020 |
LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, et al. Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. Nature Communications. 11: 1780. PMID 32286267 DOI: 10.1038/S41467-020-15440-4 |
0.411 |
|
| 2020 |
Abraham M, Gagaring K, Marino ML, Vanaerschot M, Plouffe D, Calla J, Godinez Macias K, Du A, Wree M, Antonova-Koch Y, Eribez K, Luth MR, Ottilie S, Fidock DA, McNamara C, et al. Probing the Open Global Health Chemical Diversity Library for multistage-active starting points for next-generation antimalarials. Acs Infectious Diseases. PMID 32078764 DOI: 10.1021/Acsinfecdis.9B00482 |
0.326 |
|
| 2020 |
Singh S, El-Sakkary N, Skinner DE, Sharma PP, Ottilie S, Antonova-Koch Y, Kumar P, Winzeler E, Poonam, R Caffrey C, Rathi B. Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty. Pharmaceuticals (Basel, Switzerland). 13. PMID 32028743 DOI: 10.3390/Ph13020025 |
0.306 |
|
| 2019 |
Murithi JM, Owen ES, Istvan ES, Lee MCS, Ottilie S, Chibale K, Goldberg DE, Winzeler EA, Llinás M, Fidock DA, Vanaerschot M. Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery. Cell Chemical Biology. PMID 31813848 DOI: 10.1016/J.Chembiol.2019.11.009 |
0.312 |
|
| 2019 |
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science Translational Medicine. 11. PMID 31801884 DOI: 10.1126/Scitranslmed.Aav1636 |
0.316 |
|
| 2019 |
Winzeler EA, Ottilie S. The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa. Proceedings of the National Academy of Sciences of the United States of America. 116: 10198-10200. PMID 31085658 DOI: 10.1073/Pnas.1904694116 |
0.319 |
|
| 2018 |
Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado Rodriguez JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, et al. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.). 362. PMID 30523084 DOI: 10.1126/Science.Aat9446 |
0.347 |
|
| 2018 |
Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould A, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, et al. Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. Journal of Medicinal Chemistry. PMID 30373366 DOI: 10.1021/Acs.Jmedchem.8B01161 |
0.399 |
|
| 2018 |
Ottilie S, Goldgof GM, Cheung AL, Walker JL, Vigil E, Allen KE, Antonova-Koch Y, Slayman CW, Suzuki Y, Durrant JD. Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies. Journal of Cheminformatics. 10: 6. PMID 29464421 DOI: 10.1186/S13321-018-0261-3 |
0.338 |
|
| 2018 |
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, ... ... Ottilie S, et al. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.). 359: 191-199. PMID 29326268 DOI: 10.1126/Science.Aan4472 |
0.337 |
|
| 2017 |
LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, ... ... Ottilie S, et al. Development of a potent inhibitor of the Plasmodium proteasome with reduced mammalian toxicity. Journal of Medicinal Chemistry. PMID 28696697 DOI: 10.1021/Acs.Jmedchem.7B00671 |
0.352 |
|
| 2016 |
Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, et al. Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast. Acs Chemical Biology. PMID 27977118 DOI: 10.1021/Acschembio.6B01037 |
0.372 |
|
| 2016 |
Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Stanhope R, et al. Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Scientific Reports. 6: 27806. PMID 27291296 DOI: 10.1038/Srep27806 |
0.422 |
|
| 2012 |
Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore BS, Gerwick WH. Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. The Febs Journal. 279: 1243-51. PMID 22314229 DOI: 10.1111/J.1742-4658.2012.08517.X |
0.406 |
|
| 1998 |
Sells MA, Barratt JT, Caviston J, Ottilie S, Leberer E, Chernoff J. Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. The Journal of Biological Chemistry. 273: 18490-8. PMID 9660818 DOI: 10.1074/Jbc.273.29.18490 |
0.622 |
|
| 1997 |
Ottilie S, Wang Y, Banks S, Chang J, Vigna NJ, Weeks S, Armstrong RC, Fritz LC, Oltersdorf T. Mutational analysis of the interacting cell death regulators CED-9 and CED-4. Cell Death and Differentiation. 4: 526-33. PMID 14555965 DOI: 10.1038/Sj.Cdd.4400288 |
0.411 |
|
| 1997 |
Ottilie S, Diaz J, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. Journal of Biological Chemistry. 272: 30866-30872. PMID 9388232 DOI: 10.1074/Jbc.272.49.30866 |
0.469 |
|
| 1997 |
Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. The Journal of Biological Chemistry. 272: 18542-5. PMID 9228018 DOI: 10.1074/Jbc.272.30.18542 |
0.361 |
|
| 1997 |
Ottilie S, Diaz J, Chang J, Wilson G, Tuffo KM, Weeks S, McConnell M, Wang Y, Oltersdorf T, Fritz LC. Structural and Functional Complementation of an Inactive Bcl-2 Mutant by Bax Truncation Journal of Biological Chemistry. 272: 16955-16961. PMID 9202007 DOI: 10.1074/Jbc.272.27.16955 |
0.409 |
|
| 1997 |
Jürgensmeier JM, Krajewski S, Armstrong RC, Wilson GM, Oltersdorf T, Fritz LC, Reed JC, Ottilie S. Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. Molecular Biology of the Cell. 8: 325-39. PMID 9190211 DOI: 10.1091/Mbc.8.2.325 |
0.385 |
|
| 1997 |
Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 1172-6. PMID 9037025 DOI: 10.1073/Pnas.94.4.1172 |
0.406 |
|
| 1995 |
Ottilie S, Miller PJ, Johnson DI, Creasy CL, Sells MA, Bagrodia S, Forsburg SL, Chernoff J. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. The Embo Journal. 14: 5908-5919. DOI: 10.1002/J.1460-2075.1995.Tb00278.X |
0.666 |
|
| 1994 |
Hannig G, Ottilie S, Erikson RL. Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants. Proceedings of the National Academy of Sciences of the United States of America. 91: 10084-8. PMID 7937842 DOI: 10.1073/Pnas.91.21.10084 |
0.631 |
|
| 1993 |
Hannig G, Ottilie S, Schievella AR, Erikson RL. Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells. Yeast (Chichester, England). 9: 1039-52. PMID 8256510 DOI: 10.1002/Yea.320091002 |
0.608 |
|
| 1992 |
Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Molecular and Cellular Biology. 12: 5571-80. PMID 1448087 DOI: 10.1128/Mcb.12.12.5571 |
0.657 |
|
| 1991 |
Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 88: 3455-9. PMID 1849659 DOI: 10.1073/Pnas.88.8.3455 |
0.621 |
|
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