Wulf Blankenfeldt - Publications

Sturcture and function of Proteins Helmholtz Centre for Infection Research 

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hendry S, Steinke S, Wittstein K, Stadler M, Harmrolfs K, Adewunmi Y, Sahukhal G, Elasri M, Thomashow L, Weller D, Mavrodi O, Blankenfeldt W, Mavrodi D. Functional Analysis of Phenazine Biosynthesis Genes in spp. Applied and Environmental Microbiology. PMID 33741619 DOI: 10.1128/AEM.02348-20  0.44
2021 Hoefler S, Lukat P, Blankenfeldt W, Carlomagno T. High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 N-terminal domain. Rna (New York, N.Y.). PMID 33483369 DOI: 10.1261/rna.077396.120  0.36
2021 Chaoprasid P, Lukat P, Mühlen S, Heidler T, Gazdag EM, Dong S, Bi W, Rüter C, Kirchenwitz M, Steffen A, Jänsch L, Stradal TEB, Dersch P, Blankenfeldt W. Crystal structure of bacterial cytotoxic necrotizing factor CNF reveals molecular building blocks for intoxication. The Embo Journal. e105202. PMID 33410511 DOI: 10.15252/embj.2020105202  0.36
2020 Mancini F, Unver MY, Elgaher WAM, Jumde VR, Alhayek A, Lukat P, Herrmann J, Witte MD, Köck M, Blankenfeldt W, Müller R, Hirsch AKH. Protein-Templated Hit Identification via an Ugi Four-Component Reaction. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32428268 DOI: 10.1002/chem.202002250  0.44
2020 Hercher TW, Krausze J, Hoffmeister S, Zwerschke D, Lindel T, Blankenfeldt W, Mendel RR, Kruse T. Insights into the Cnx1E catalyzed MPT-AMP hydrolysis. Bioscience Reports. 40. PMID 31860061 DOI: 10.1042/BSR20191806  0.68
2019 Zender M, Witzgall F, Kiefer AF, Kirsch B, Maurer CK, Kany AM, Xu N, Schmelz S, Börger C, Blankenfeldt W, Empting M. Flexible Fragment Growing Boosts Potency of Quorum Sensing Inhibitors against Pseudomonas aeruginosa Virulence. Chemmedchem. PMID 31709767 DOI: 10.1002/cmdc.201900621  0.44
2019 Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F. Crystal structure of -aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548418 DOI: 10.1073/pnas.1908770116  0.36
2019 Mayer J, Pippel J, Günther G, Müller C, Lauermann A, Knuuti T, Blankenfeldt W, Jahn D, Biedendieck R. Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability. Applied Microbiology and Biotechnology. PMID 31227867 DOI: 10.1007/s00253-019-09977-8  0.68
2018 Schwemmlein N, Pippel J, Gazdag EM, Blankenfeldt W. Crystal Structures of R-Type Bacteriocin Sheath and Tube Proteins CD1363 and CD1364 From in the Pre-assembled State. Frontiers in Microbiology. 9: 1750. PMID 30127773 DOI: 10.3389/fmicb.2018.01750  0.36
2018 Witzgall F, Depke T, Hoffmann M, Empting M, Brönstrup M, Müller R, Blankenfeldt W. The Alkylquinolone Repertoire of Pseudomonas aeruginosa is linked to Structural Flexibility of the FabH-like PQS Biosynthesis Enzyme PqsBC. Chembiochem : a European Journal of Chemical Biology. PMID 29722462 DOI: 10.1002/cbic.201800153  0.44
2018 Krausze J, Hercher TW, Zwerschke D, Kirk ML, Blankenfeldt W, Mendel RR, Kruse T. The functional principle of eukaryotic molybdenum insertases. The Biochemical Journal. PMID 29717023 DOI: 10.1042/BCJ20170935  0.68
2017 Lukat P, Katsuyama Y, Wenzel S, Binz T, König C, Blankenfeldt W, Brönstrup M, Müller R. Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Chemical Science. 8: 7521-7527. PMID 29163906 DOI: 10.1039/c7sc02622f  0.44
2017 von Tesmar A, Hoffmann M, Pippel J, Fayad AA, Dausend-Werner S, Bauer A, Blankenfeldt W, Müller R. Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System. Cell Chemical Biology. PMID 28890318 DOI: 10.1016/j.chembiol.2017.08.001  0.44
2017 Witzgall F, Ewert W, Blankenfeldt W. Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis. Chembiochem : a European Journal of Chemical Biology. 18: 2045-2055. PMID 28834007 DOI: 10.1002/cbic.201700374  0.44
2017 Bock T, Luxenburger E, Hoffmann J, Schütza V, Feiler C, Müller R, Blankenfeldt W. AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angewandte Chemie (International Ed. in English). PMID 28508504 DOI: 10.1002/anie.201701992  0.44
2017 Dolan SK, Bock T, Hering V, Owens RA, Jones GW, Blankenfeldt W, Doyle S. Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. Open Biology. 7. PMID 28179499 DOI: 10.1098/rsob.160292  0.36
2016 Bock T, Volz C, Hering V, Scrima A, Müller R, Blankenfeldt W. The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus. Nucleic Acids Research. PMID 27940564 DOI: 10.1093/nar/gkw1238  0.44
2016 Bock T, Müller R, Blankenfeldt W. Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus. Acta Crystallographica. Section F, Structural Biology Communications. 72: 652-8. PMID 27487931 DOI: 10.1107/S2053230X16011146  0.36
2016 Füller JJ, Röpke R, Krausze J, Rennhack KE, Daniel NP, Blankenfeldt W, Schulz S, Jahn D, Moser J. Biosynthesis of Violacein: Structure and Function of L-Tryptophan Oxidase VioA from Chromobacterium violaceum. The Journal of Biological Chemistry. PMID 27466367 DOI: 10.1074/jbc.M116.741561  0.68
2016 Bock T, Reichelt J, Müller R, Blankenfeldt W. The structure of LiuC, a 3-hydroxy-3-methylglutaconyl CoA dehydratase involved in isovaleryl CoA biosynthesis in Myxococcus xanthus, reveals insights into specificity and catalysis. Chembiochem : a European Journal of Chemical Biology. PMID 27271456 DOI: 10.1002/cbic.201600225  0.36
2016 Bock T, Kasten J, Müller R, Blankenfeldt W. Crystal structure of the HMG-CoA synthase MvaS from the Gram-negative bacterium Myxococcus xanthus. Chembiochem : a European Journal of Chemical Biology. PMID 27124816 DOI: 10.1002/cbic.201600070  0.36
2016 Zender M, Witzgall F, Drees SL, Weidel E, Maurer CK, Fetzner S, Blankenfeldt W, Empting M, Hartmann RW. Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds. Acs Chemical Biology. 11: 1755-63. PMID 27082157 DOI: 10.1021/acschembio.6b00156  0.44
2013 Feiler C, Fisher AC, Boock JT, Marrichi MJ, Wright L, Schmidpeter PA, Blankenfeldt W, Pavelka M, DeLisa MP. Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency. Plos One. 8: e73123. PMID 24023821 DOI: 10.1371/journal.pone.0073123  0.36
2013 Mavrodi DV, Parejko JA, Mavrodi OV, Kwak YS, Weller DM, Blankenfeldt W, Thomashow LS. Recent insights into the diversity, frequency and ecological roles of phenazines in fluorescent Pseudomonas spp. Environmental Microbiology. 15: 675-86. PMID 22882648 DOI: 10.1111/j.1462-2920.2012.02846.x  0.36
2012 Hoeppner A, Thomas F, Rueppel A, Hensel R, Blankenfeldt W, Bayer P, Faust A. Structure of the corrinoid:coenzyme M methyltransferase MtaA from Methanosarcina mazei Acta Crystallographica Section D: Biological Crystallography. 68: 1549-1557. PMID 23090404 DOI: 10.1107/S090744491203853X  0.36
2012 Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS. Development of selective, potent RabGGTase inhibitors. Journal of Medicinal Chemistry. 55: 8330-40. PMID 22963166 DOI: 10.1021/jm300624s  0.36
2012 Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. Journal of the American Chemical Society. 134: 7384-91. PMID 22480322 DOI: 10.1021/ja211305j  0.36
2011 Mueller JW, Link NM, Matena A, Hoppstock L, Rüppel A, Bayer P, Blankenfeldt W. Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases Journal of the American Chemical Society. 133: 20096-20099. PMID 22081960 DOI: 10.1021/ja2086195  0.36
2011 Waldmüller S, Erdmann J, Binner P, Gelbrich G, Pankuweit S, Geier C, Timmermann B, Haremza J, Perrot A, Scheer S, Wachter R, Schulze-Waltrup N, Dermintzoglou A, Schönberger J, Zeh W, ... ... Blankenfeldt W, et al. Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure. European Journal of Heart Failure. 13: 1185-92. PMID 21750094 DOI: 10.1093/eurjhf/hfr074  0.36
2011 Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H. Structure-guided development of selective RabGGTase inhibitors. Angewandte Chemie (International Ed. in English). 50: 4957-61. PMID 21520375 DOI: 10.1002/anie.201101210  0.36
2011 Alexandrov K, Wu Y, Blankenfeldt W, Waldmann H, Goody RS. Organization and Function of the Rab Prenylation and Recycling Machinery Enzymes. 29: 147-162. DOI: 10.1016/B978-0-12-381339-8.00008-1  0.36
2010 Mavrodi DV, Peever TL, Mavrodi OV, Parejko JA, Raaijmakers JM, Lemanceau P, Mazurier S, Heide L, Blankenfeldt W, Weller DM, Thomashow LS. Diversity and evolution of the phenazine biosynthesis pathway. Applied and Environmental Microbiology. 76: 866-79. PMID 20008172 DOI: 10.1128/AEM.02009-09  0.36
2009 Mentel M, Blankenfeldt W, Breinbauer R. The active site of an enzyme can host both enantiomers of a racemic ligand simultaneously. Angewandte Chemie (International Ed. in English). 48: 9084-7. PMID 19876985 DOI: 10.1002/anie.200902997  0.36
2009 Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Häussler S, Blankenfeldt W. Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein. Biochemistry. 48: 10298-307. PMID 19788310 DOI: 10.1021/bi900123j  0.36
2009 Sychrovsky V, Foldynova-Trantirkova S, Spackova N, Robeyns K, Van Meervelt L, Blankenfeldt W, Vokacova Z, Sponer J, Trantirek L. Revisiting the planarity of nucleic acid bases: Pyramidilization at glycosidic nitrogen in purine bases is modulated by orientation of glycosidic torsion. Nucleic Acids Research. 37: 7321-31. PMID 19786496 DOI: 10.1093/nar/gkp783  0.36
2009 Mentel M, Ahuja EG, Mavrodi DV, Breinbauer R, Thomashow LS, Blankenfeldt W. Of two make one: the biosynthesis of phenazines. Chembiochem : a European Journal of Chemical Biology. 10: 2295-304. PMID 19658148 DOI: 10.1002/cbic.200900323  0.36
2009 Nguyen UT, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon RS, Blankenfeldt W, Goody RS, Waldmann H, Wolters D, Alexandrov K. Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nature Chemical Biology. 5: 227-35. PMID 19219049 DOI: 10.1038/nchembio.149  0.36
2008 Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W. PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis. Journal of the American Chemical Society. 130: 17053-61. PMID 19053436 DOI: 10.1021/ja806325k  0.36
2008 Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. The Embo Journal. 27: 2444-56. PMID 18756270 DOI: 10.1038/emboj.2008.164  0.36
2008 Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angewandte Chemie (International Ed. in English). 47: 3747-50. PMID 18399557 DOI: 10.1002/anie.200705795  0.36
2006 Blankenfeldt W, Thomä NH, Wray JS, Gautel M, Schlichting I. Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment. Proceedings of the National Academy of Sciences of the United States of America. 103: 17713-7. PMID 17095604 DOI: 10.1073/pnas.0606741103  0.36
2003 Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH. High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme Structure. 11: 715-723. PMID 12791259 DOI: 10.1016/S0969-2126(03)00098-4  0.36
2003 Kerr ID, Wadsworth RI, Cubeddu L, Blankenfeldt W, Naismith JH, White MF. Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. The Embo Journal. 22: 2561-70. PMID 12773373 DOI: 10.1093/emboj/cdg272  0.36
2003 Dong C, Beis K, Giraud MF, Blankenfeldt W, Allard S, Major LL, Kerr ID, Whitfield C, Naismith JH. A structural perspective on the enzymes that convert dTDP-D-glucose into dTDP-L-rhamnose Biochemical Society Transactions. 31: 532-536. PMID 12773151 DOI: 10.1042/BST0310532  0.36
2002 Blankenfeldt W, Kerr ID, Giraud MF, McMiken HJ, Leonard G, Whitfield C, Messner P, Graninger M, Naismith JH. Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure (London, England : 1993). 10: 773-86. PMID 12057193 DOI: 10.1016/S0969-2126(02)00770-0  0.36
2002 Asuncion M, Blankenfeldt W, Barlow JN, Gani D, Naismith JH. The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step. The Journal of Biological Chemistry. 277: 8306-11. PMID 11748244 DOI: 10.1074/jbc.M111180200  0.36
2001 Kerr ID, Wadsworth RI, Blankenfeldt W, Staines AG, White MF, Naismith JH. Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus. Acta Crystallographica. Section D, Biological Crystallography. 57: 1290-2. PMID 11526322 DOI: 10.1107/S0907444901011374  0.36
2001 Asuncion M, Barlow JN, Pollard J, Staines AG, McMahon SA, Blankenfeldt W, Gani D, Naismith JH. Overexpression, purification, crystallization and data collection of 3-methylaspartase from Clostridium tetanomorphum. Acta Crystallographica. Section D, Biological Crystallography. 57: 731-3. PMID 11320320 DOI: 10.1107/S0907444901003225  0.36
2000 Blankenfeldt W, Asuncion M, Lam JS, Naismith JH. The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA) Embo Journal. 19: 6652-6663. PMID 11118200 DOI: 10.1093/emboj/19.24.6652  0.36
2000 Blankenfeldt W, Giraud MF, Leonard G, Rahim R, Creuzenet C, Lam JS, Naismith JH. The purification, crystallization and preliminary structural characterization of glucose-1-phosphate thymidylyltransferase (RmlA), the first enzyme of the dTDP-L-rhamnose synthesis pathway from Pseudomonas aeruginosa. Acta Crystallographica. Section D, Biological Crystallography. 56: 1501-4. PMID 11053865 DOI: 10.1107/S0907444900010040  0.36
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