John Charles Williams - Publications

Beckman Research Institute of City of Hope, Monrovia, CA, United States 
protein engineering

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Guo C, Williams JC, Polenova T. Conformational Flexibility of p150(1-191) Subunit of Dynactin Assembled with Microtubules. Biophysical Journal. PMID 31445682 DOI: 10.1016/J.Bpj.2019.07.036  0.76
2018 Karow M, Jenkins K, Park M, Johnson P, Gonzalez A, Flesch V, Miles T, Rodeck U, Williams JC. Pre-clinical assessment of rational design immuno-oncology biologics with improved therapeutic indices. Journal of Clinical Oncology. 36. DOI: 10.1200/Jco.2018.36.15_Suppl.E15096  0.48
2017 Herrmann A, Lahtz C, Nagao T, Song JY, Chan WC, Lee H, Yue C, Look T, Muelfarth R, Li W, Jenkins K, Williams J, Budde LE, Forman SJ, Kwak LW, et al. CTLA4 promotes Tyk2-STAT3 dependent B cell oncogenecity. Cancer Research. PMID 28716895 DOI: 10.1158/0008-5472.Can-16-0342  0.32
2016 Hillmann F, Bagramyan K, Straßburger M, Heinekamp T, Hong TB, Bzymek KP, Williams JC, Brakhage AA, Kalkum M. The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus. Scientific Reports. 6: 33396. PMID 27624005 DOI: 10.1038/Srep33396  1
2016 Bzymek KP, Ma Y, Avery KA, Horne DA, Williams JC. Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallographica. Section F, Structural Biology Communications. 72: 434-442. PMID 27303895 DOI: 10.1107/S2053230X16007202  1
2015 Yan S, Guo C, Hou G, Zhang H, Lu X, Williams JC, Polenova T. Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 112: 14611-6. PMID 26604305 DOI: 10.1073/Pnas.1509852112  1
2015 Alontaga AY, Ambaye ND, Li YJ, Vega R, Chen CH, Bzymek KP, Williams JC, Hu W, Chen Y. RWD Domain as an E2 (Ubc9)-Interaction Module. The Journal of Biological Chemistry. 290: 16550-9. PMID 25918163 DOI: 10.1074/jbc.M115.644047  1
2015 Avery KN, Zer C, Bzymek KP, Williams JC. Development of a high affinity, non-covalent biologic to add functionality to Fabs. Scientific Reports. 5: 7817. PMID 25588710 DOI: 10.1038/Srep07817  1
2015 Küçük C, Jiang B, Hu X, Zhang W, Chan JK, Xiao W, Lack N, Alkan C, Williams JC, Avery KN, Kavak P, Scuto A, Sen E, Gaulard P, Staudt L, et al. Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. Nature Communications. 6: 6025. PMID 25586472 DOI: 10.1038/Ncomms7025  1
2015 Yan S, Zhang H, Hou G, Ahmed S, Williams JC, Polenova T. Internal dynamics of dynactin CAP-Gly is regulated by microtubules and plus end tracking protein EB1. The Journal of Biological Chemistry. 290: 1607-22. PMID 25451937 DOI: 10.1074/Jbc.M114.603118  0.76
2014 Ahmed S, Xie J, Horne D, Williams JC. Photocleavable dimerizer for the rapid reversal of molecular trap antagonists. The Journal of Biological Chemistry. 289: 4546-52. PMID 24421317 DOI: 10.1074/Jbc.C113.513622  1
2013 Donaldson JM, Zer C, Avery KN, Bzymek KP, Horne DA, Williams JC. Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America. 110: 17456-61. PMID 24101516 DOI: 10.1073/Pnas.1307309110  1
2013 Yan S, Hou G, Schwieters CD, Ahmed S, Williams JC, Polenova T. Three-dimensional structure of CAP-gly domain of mammalian dynactin determined by magic angle spinning NMR spectroscopy: conformational plasticity and interactions with end-binding protein EB1. Journal of Molecular Biology. 425: 4249-66. PMID 23648839 DOI: 10.1016/J.Jmb.2013.04.027  1
2013 Siglin AE, Sun S, Moore JK, Tan S, Poenie M, Lear JD, Polenova T, Cooper JA, Williams JC. Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. Plos One. 8: e59453. PMID 23577064 DOI: 10.1371/Journal.Pone.0059453  1
2012 Sun S, Yan S, Guo C, Li M, Hoch JC, Williams JC, Polenova T. A time-saving strategy for MAS NMR spectroscopy by combining nonuniform sampling and paramagnetic relaxation assisted condensed data collection. The Journal of Physical Chemistry. B. 116: 13585-96. PMID 23094591 DOI: 10.1021/Jp3005794  1
2012 Sun S, Han Y, Paramasivam S, Yan S, Siglin AE, Williams JC, Byeon IJ, Ahn J, Gronenborn AM, Polenova T. Solid-state NMR spectroscopy of protein complexes. Methods in Molecular Biology (Clifton, N.J.). 831: 303-31. PMID 22167681 DOI: 10.1007/978-1-61779-480-3_17  1
2011 Sun S, Butterworth AH, Paramasivam S, Yan S, Lightcap CM, Williams JC, Polenova T. Resonance Assignments and Secondary Structure Analysis of Dynein Light Chain 8 by Magic Angle Spinning NMR Spectroscopy. Canadian Journal of Chemistry. 89: 909-918. PMID 23243318 DOI: 10.1139/V11-030  1
2011 Stuchell-Brereton MD, Siglin A, Li J, Moore JK, Ahmed S, Williams JC, Cooper JA. Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell. 22: 2690-701. PMID 21633107 DOI: 10.1091/Mbc.E11-01-0075  1
2011 Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, ... ... Williams JC, et al. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. Acs Chemical Biology. 6: 432-43. PMID 21226522 DOI: 10.1021/Cb100253E  1
2010 Ahmed S, Sun S, Siglin AE, Polenova T, Williams JC. Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain. Biochemistry. 49: 5083-5. PMID 20518521 DOI: 10.1021/Bi100235Z  1
2010 Varma D, Dawn A, Ghosh-Roy A, Weil SJ, Ori-McKenney KM, Zhao Y, Keen J, Vallee RB, Williams JC. Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes. Proceedings of the National Academy of Sciences of the United States of America. 107: 3493-8. PMID 20133681 DOI: 10.1073/Pnas.0908959107  1
2009 Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biology & Therapy. 8: 2147-52. PMID 19783899  0.48
2009 Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. The Journal of Biological Chemistry. 284: 29860-72. PMID 19710023 DOI: 10.1074/Jbc.M109.023366  1
2009 Sun S, Siglin A, Williams JC, Polenova T. Solid-state and solution NMR studies of the CAP-Gly domain of mammalian dynactin and its interaction with microtubules. Journal of the American Chemical Society. 131: 10113-26. PMID 19580321 DOI: 10.1021/Ja902003U  1
2009 Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. Plos One. 4: e6025. PMID 19557173 DOI: 10.1371/Journal.Pone.0006025  0.52
2009 Höök P, Yagi T, Ghosh-Roy A, Williams JC, Vallee RB. The dynein stalk contains an antiparallel coiled coil with region-specific stability. Biochemistry. 48: 2710-3. PMID 19222235 DOI: 10.1021/Bi900223X  1
2008 Rodeck U, Williams JC. Nature's design: A blueprint for engineered therapeutic antibodies. Cancer Biology & Therapy. 7: 1751-2. PMID 18981729 DOI: 10.4161/Cbt.7.11.7157  0.48
2008 Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, Williams JC. Biochemical and structural characterization of the Pak1-LC8 interaction. The Journal of Biological Chemistry. 283: 27314-24. PMID 18650427 DOI: 10.1074/Jbc.M800758200  1
2008 Kamat V, Donaldson JM, Kari C, Quadros MR, Lelkes PI, Chaiken I, Cocklin S, Williams JC, Papazoglou E, Rodeck U. Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425. Cancer Biology & Therapy. 7: 726-33. PMID 18424917 DOI: 10.4161/Cbt.7.5.6097  1
2007 Williams JC, Roulhac PL, Roy AG, Vallee RB, Fitzgerald MC, Hendrickson WA. Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proceedings of the National Academy of Sciences of the United States of America. 104: 10028-33. PMID 17551010 DOI: 10.1073/Pnas.0703614104  1
2007 Tan GS, Preuss MA, Williams JC, Schnell MJ. The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 7229-34. PMID 17438267 DOI: 10.1073/Pnas.0701397104  1
2005 Williams JC, Xie H, Hendrickson WA. Crystal structure of dynein light chain TcTex-1 Journal of Biological Chemistry. 280: 21981-21986. PMID 15701632 DOI: 10.1074/Jbc.M414643200  1
2005 Williams JC, Sue C, Banting GB, Yang H, Glerum DM, Hendrickson WA, Schon EA. Crystal structure of human SCO1: Implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein Journal of Biological Chemistry. 280: 15202-15211. PMID 15659396 DOI: 10.1074/Jbc.M410705200  1
2004 Vallee RB, Williams JC, Varma D, Barnhart LE. Dynein: An ancient motor protein involved in multiple modes of transport. Journal of Neurobiology. 58: 189-200. PMID 14704951 DOI: 10.1002/Neu.10314  1
1998 Williams JC, Wierenga RK, Saraste M. Insights into Src kinase functions: structural comparisons. Trends in Biochemical Sciences. 23: 179-84. PMID 9612082 DOI: 10.1016/S0968-0004(98)01202-X  1
1995 Williams JC, McDermott AE. Dynamics of the flexible loop of triosephosphate isomerase: the loop motion is not ligand gated. Biochemistry. 34: 8309-19. PMID 7599123 DOI: 10.1021/Bi00026A012  1
1994 Copié V, McDermott AE, Beshah K, Williams JC, Spijker-Assink M, Gebhard R, Lugtenburg J, Herzfeld J, Griffin RG. Deuterium solid-state nuclear magnetic resonance studies of methyl group dynamics in bacteriorhodopsin and retinal model compounds: evidence for a 6-s-trans chromophore in the protein. Biochemistry. 33: 3280-6. PMID 8136363 DOI: 10.1021/Bi00177A019  1
1993 Williams JC, McDermott AE. Cis-trans energetics in urea and acetamide studied by deuterium NMR Journal of Physical Chemistry. 97: 12393-12398. DOI: 10.1021/J100149A047  1
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