Melvin Cohn - Publications

Affiliations: 
Conceptual Immunology Salk Institute for Biological Studies, La Jolla, CA, United States 
Area:
immune response
Website:
http://www.salk.edu/faculty/cohn.html

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cohn M. Exploring the elements for a successful immune offense against cancer. Experimental and Molecular Pathology. 105: 213-215. PMID 30130493 DOI: 10.1016/J.Yexmp.2018.08.006  0.307
2018 Cohn M. Somatic diversification of the B-cell repertoire requires two cell subsets. Scandinavian Journal of Immunology. PMID 29314175 DOI: 10.1111/Sji.12640  0.337
2017 Cohn M. A commentary on a workshop "to reveal the foundational concepts of immune regulation" (i.e., tolerance). Scandinavian Journal of Immunology. PMID 28199746 DOI: 10.1111/Sji.12536  0.309
2016 Cohn M. Core principles characterizing immune function. European Journal of Immunology. PMID 28000923 DOI: 10.1002/Eji.201646706  0.318
2016 Cohn M. Dissecting the two models of TCR structure-function relationships. Immunologic Research. PMID 27114367 DOI: 10.1007/S12026-016-8796-8  0.318
2015 Cohn M. Two unresolved problems facing models of the Self-Nonself discrimination. Journal of Theoretical Biology. 387: 31-8. PMID 26449741 DOI: 10.1016/J.Jtbi.2015.09.021  0.3
2015 Cohn M. Rationalizing thymic selection for functional T-cells: A commentary. Cellular Immunology. PMID 26429627 DOI: 10.1016/J.Cellimm.2015.09.008  0.313
2015 Cohn M. What would Treg-cell biology look like when viewed from a rationalized perspective? European Journal of Immunology. PMID 26256556 DOI: 10.1002/Eji.201545799  0.334
2014 Cohn M. A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells). Cellular and Molecular Life Sciences : Cmls. 71: 2033-45. PMID 24337779 DOI: 10.1007/S00018-013-1540-9  0.34
2013 Cohn M. Challenging the Tritope Model of T cell receptor structure-function relationships with classical data on 'super' and 'allo-MHC' antigens. Scandinavian Journal of Immunology. 78: 313-24. PMID 23809024 DOI: 10.1111/Sji.12092  0.321
2012 Cohn M. What is so special about thinking; after all, we all do it! Experimental and Molecular Pathology. 93: 354-64. PMID 22944224 DOI: 10.1016/J.Yexmp.2012.08.001  0.312
2012 Cohn M. Musings about regulation by T-suppressors: a response to the commentary by Kristofor Ellestad on 'Meanderings into the regulation of effector class by the immune system: derivation of the trauma model'. Scandinavian Journal of Immunology. 76: 92-8. PMID 22631212 DOI: 10.1111/J.1365-3083.2012.02723.X  0.337
2012 Cohn M. Meanderings into the regulation of effector class by the immune system: derivation of the trauma model. Scandinavian Journal of Immunology. 76: 77-88. PMID 22606953 DOI: 10.1111/J.1365-3083.2012.02721.X  0.308
2009 Cohn M. Why Aire? Compensating for late bloomers. European Journal of Immunology. 39: 2969-72. PMID 19688745 DOI: 10.1002/Eji.200939628  0.324
2009 Cohn M. On the critique by Colin Anderson of 'A reply to Dembic: on an end to the beginning of mis-understanding the immune response'. Scandinavian Journal of Immunology. 70: 1-9. PMID 19522761 DOI: 10.1111/J.1365-3083.2009.02264.X  0.309
2009 Cohn M. On the opposing views of the self-nonself discrimination by the immune system. Immunology and Cell Biology. 87: 113-9, discussion 12. PMID 19048020 DOI: 10.1038/Icb.2008.96  0.303
2009 Cohn M. How does the immune response get started? Cellular Immunology. 254: 91-3. PMID 19022423 DOI: 10.1016/J.Cellimm.2008.10.005  0.365
2008 Cohn M. What roles do regulatory T cells play in the control of the adaptive immune response? International Immunology. 20: 1107-18. PMID 18658168 DOI: 10.1093/Intimm/Dxn088  0.312
2008 Cohn M. An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition. Immunologic Research. 40: 128-47. PMID 18213526 DOI: 10.1007/S12026-007-8003-Z  0.311
2008 Cohn M. The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology. Molecular Immunology. 45: 632-52. PMID 17889366 DOI: 10.1016/J.Molimm.2006.02.033  0.335
2007 Cohn M, Mitchison NA, Paul WE, Silverstein AM, Talmage DW, Weigert M. Reflections on the clonal-selection theory. Nature Reviews. Immunology. 7: 823-30. PMID 17893695 DOI: 10.1038/Nri2177  0.585
2007 Cohn M, Mata J. Quantitative modeling of immune responses. Immunological Reviews. 216: 5-8. PMID 17367330 DOI: 10.1111/J.1600-065X.2006.00492.X  0.306
2006 Cohn M. Does the signal for the activation of T cells originate from the antigen-presenting cell or the effector T-helper? Cellular Immunology. 241: 1-6. PMID 16963007 DOI: 10.1016/J.Cellimm.2006.07.010  0.349
2006 Cohn M. On 'Credo 2004' as viewed under the 'development-context' model of Colin Anderson. Scandinavian Journal of Immunology. 64: 97-103. PMID 16867154 DOI: 10.1111/J.1365-3083.2006.01790.X  0.322
2006 Cohn M. What are the commonalities governing the behavior of humoral immune recognitive repertoires? Developmental and Comparative Immunology. 30: 19-42. PMID 16139887 DOI: 10.1016/J.Dci.2005.06.015  0.353
2005 Cohn M. The Tritope Model for restrictive recognition of antigen by T-cells I. What assumptions about structure are needed to explain function? Molecular Immunology. 42: 1419-43. PMID 15950737 DOI: 10.1016/J.Molimm.2005.01.013  0.353
2005 Cohn M. A biological context for the self-nonself discrimination and the regulation of effector class by the immune system. Immunologic Research. 31: 133-50. PMID 15778511 DOI: 10.1385/Ir:31:2:133  0.303
2005 Cohn M. The common sense of the self-nonself discrimination. Springer Seminars in Immunopathology. 27: 3-17. PMID 15711952 DOI: 10.1007/S00281-005-0199-1  0.306
2005 Cohn M. Degeneracy, mimicry and crossreactivity in immune recognition. Molecular Immunology. 42: 651-5. PMID 15607824 DOI: 10.1016/J.Molimm.2004.09.010  0.345
2004 Cohn M. If the "adaptive" immune system can recognize a significant portion of the pathogenic universe to which the "innate" immune system is blind, then... Scandinavian Journal of Immunology. 60: 1-2. PMID 15238064 DOI: 10.1111/J.0300-9475.2004.01449.X  0.31
2004 Cohn M. Whither T-suppressors: if they didn't exist would we have to invent them? Cellular Immunology. 227: 81-92. PMID 15135290 DOI: 10.1016/J.Cellimm.2004.02.004  0.302
2004 Cohn M. An alternative to current thinking about positive selection, negative selection and activation of T cells. Immunology. 111: 375-80. PMID 15056372 DOI: 10.1111/J.0019-2805.2004.01830.X  0.316
2004 MONOD J, COHEN-BAZIRE G, COHN M. [The biosynthesis of beta-galactosidase (lactase) in Escherichia coli; the specificity of induction]. Biochimica Et Biophysica Acta. 7: 585-99. PMID 14904456 DOI: 10.1016/0006-3002(51)90072-8  0.669
2004 COHN M, MONOD J. [Purification and properties of the beta-galactosidase (lactase) of Escherichia coli]. Biochimica Et Biophysica Acta. 7: 153-74. PMID 14848081 DOI: 10.1016/0006-3002(51)90013-3  0.664
2004 Cohn M, Dembic Z. Response to Dembic: Does the immune system reject the harmful, protect the useful and neglect the rest? Scandinavian Journal of Immunology. 60: 6-8. DOI: 10.1111/J.0300-9475.2004.01452.X  0.342
2003 COHN M, TORRIANI AM. The relationships in biosynthesis of the beta-galactosidase- and Pz-proteins in Escherichia coli. Biochimica Et Biophysica Acta. 10: 280-9. PMID 13051404 DOI: 10.1016/0006-3002(53)90251-0  0.327
2003 Cohn M. Does complexity belie a simple decision--on the Efroni and Cohen critique of the minimal model for a self-nonself discrimination. Cellular Immunology. 221: 138-42. PMID 12747955 DOI: 10.1016/S0008-8749(03)00075-3  0.302
2003 Cohn M. Tritope model of restrictive recognition by the TCR. Trends in Immunology. 24: 127-31. PMID 12615207 DOI: 10.1016/S1471-4906(03)00021-8  0.314
2002 Langman RE, Cohn M. If the immune repertoire evolved to be large, random, and somatically generated, then... Cellular Immunology. 216: 15-22. PMID 12381346 DOI: 10.1016/S0008-8749(02)00503-8  0.367
2002 Cohn M, Langman RE, Mata JJ. A computerized model for the self-non-self discrimination at the level of the T(h) (Th genesis). I. The origin of 'primer' effector T(h) cells. International Immunology. 14: 1105-12. PMID 12356676 DOI: 10.1093/Intimm/Dxf078  0.303
2002 Cohn M. The immune system: a weapon of mass destruction invented by evolution to even the odds during the war of the DNAs. Immunological Reviews. 185: 24-38. PMID 12190919 DOI: 10.1034/J.1600-065X.2002.18504.X  0.334
2002 Langman R, Cohn M. Haplotype exclusion: the solution to a problem in natural selection. Seminars in Immunology. 14: 153-62; discussion 2. PMID 12160643 DOI: 10.1016/S1044-5323(02)00039-8  0.305
2000 Cohn M. The biology of recognitive repertoires. Immunology Today. 21: 433-5. PMID 11012245 DOI: 10.1016/S0167-5699(00)01677-7  0.333
2000 Langman RE, Cohn M. A minimal model for the self-nonself discrimination: a return to the basics. Seminars in Immunology. 12: 189-95; discussion 2. PMID 10910739 DOI: 10.1006/Smim.2000.0231  0.36
1999 Langman RE, Cohn M. Away with words: commentary on the Atlan-Cohen essay 'Immune information, self-organization and meaning'. International Immunology. 11: 865-70. PMID 10360959 DOI: 10.1093/Intimm/11.6.865  0.325
1997 Langman RE, Cohn M. A short history of time and space in immune discrimination: reply to the commentaries. Scandinavian Journal of Immunology. 46: 113-6. PMID 9583990 DOI: 10.1046/J.1365-3083.1997.D01-110.X  0.334
1997 Cohn M. Some thoughts on the response to antigens that are effector T-helper independent ('thymus independence') Scandinavian Journal of Immunology. 46: 565-71. PMID 9420619 DOI: 10.1046/J.1365-3083.1997.D01-172.X  0.36
1997 Cohn M. A new concept of immune specificity emerges from a consideration of the self-nonself discrimination. Cellular Immunology. 181: 103-8. PMID 9398397 DOI: 10.1006/Cimm.1997.1212  0.341
1997 Langman RE, Cohn M. The essential self: A commentary on Silverstein and Rose 'On the mystique of the immunological self' Immunological Reviews. 159: 214-217. DOI: 10.1111/J.1600-065X.1997.Tb01020.X  0.328
1996 WILLSON C, PERRIN D, COHN M, JACOB F, MONOD J. NON-INDUCIBLE MUTANTS OF THE REGULATOR GENE IN THE "LACTOSE" SYSTEM OF ESCHERICHIA COLI. Journal of Molecular Biology. 8: 582-92. PMID 14153528 DOI: 10.1016/S0022-2836(64)80013-9  0.651
1995 Langman RE, Cohn M. The proportion of B-cell subsets expressing kappa and lambda light chains changes following antigenic selection. Immunology Today. 16: 141-4. PMID 7718087 DOI: 10.1016/0167-5699(95)80131-6  0.3
1994 Cohn M. The wisdom of hindsight. Annual Review of Immunology. 12: 1-62. PMID 7516667 DOI: 10.1146/Annurev.Iy.12.040194.000245  0.301
1993 Langman RE, Cohn M. A theory of the ontogeny of the chicken humoral immune system: the consequences of diversification by gene hyperconversion and its extension to rabbit. Research in Immunology. 144: 422-46. PMID 8303061 DOI: 10.1016/0923-2494(93)80126-J  0.312
1992 Ying L, Divis SJ, Langman R, Epstein R, Cohn M. Is the establishing of tolerance to self obligatorily MHC restricted? Immunology Letters. 31: 21-5. PMID 1548031 DOI: 10.1016/0165-2478(92)90005-9  0.345
1992 Lin Y, Langman R, Cohn M. The priming of cytotoxic T-cell precursors is strictly helper T cell-dependent. Scandinavian Journal of Immunology. 35: 621-6. PMID 1533730 DOI: 10.1111/J.1365-3083.1992.Tb03262.X  0.304
1992 Langman RE, Cohn M. What is the selective pressure that maintains the gene loci encoding the antigen receptors of T and B cells? A hypothesis. Immunology and Cell Biology. 70: 397-404. PMID 1289241 DOI: 10.1038/Icb.1992.52  0.358
1987 Gersten MJ, Cohn M. T cell responses studied in a basal serum-free medium Methods in Enzymology. 150: 129-133. PMID 2963193 DOI: 10.1016/0076-6879(87)50073-8  0.35
1986 Tittle TV, Cohn M. A characterization of the BALB/c lambda and kappa class antibodies to alpha (1,3) glycosidic linkages. Cellular Immunology. 98: 444-52. PMID 2428525 DOI: 10.1016/0008-8749(86)90303-5  0.329
1985 Lin Y, Patek PQ, Collins JL, Cohn M. Analysis of immune surveillance of sequentially derived cell lines that differ in their tumorigenic potential1, 2 Journal of the National Cancer Institute. 74: 1025-1030. PMID 3873568 DOI: 10.1093/Jnci/74.5.1025  0.342
1985 Gersten MJ, Cohn M. A defined basal medium for study of in vitro T-cell responses Cellular Immunology. 91: 143-158. PMID 3155998 DOI: 10.1016/0008-8749(85)90039-5  0.316
1985 Epstein R, Roehm N, Marrack P, Kappler J, Davis M, Hedrick S, Cohn M. Genetic markers of the antigen-specific T cell receptor locus. The Journal of Experimental Medicine. 161: 1219-24. PMID 2580936 DOI: 10.1084/Jem.161.5.1219  0.342
1985 Langman RE, Cohn M. T cells function via restricted recognition of antigen, not antigen-restricted recognition. Cellular Immunology. 94: 598-608. PMID 2411430 DOI: 10.1016/0008-8749(85)90283-7  0.321
1984 Weiss S, Lehmann K, Cohn M. Monoclonal antibodies to murine immunoglobulin isotypes. Hybridoma. 2: 49-54. PMID 6432679 DOI: 10.1089/Hyb.1983.2.49  0.31
1983 Cohn M. The T-cell receptor mediating restrictive recognition of antigen. Cell. 33: 657-69. PMID 6191867 DOI: 10.1016/0092-8674(83)90009-0  0.345
1981 Cohn M. Conversations with Niels Kaj Jerne on immune regulation: associative versus network recognition. Cellular Immunology. 61: 425-36. PMID 6166399 DOI: 10.1016/0008-8749(81)90390-7  0.363
1979 Stallcup WB, Cohn M. Cell-specific antisera as reagents for studying the nervous system Trends in Neurosciences. 2: 20-23. DOI: 10.1016/0166-2236(79)90010-9  0.3
1978 Cohn M, Epstein R. T-cell inhibition of humoral responsiveness. II. Theory on the role of restrictive recognition in immune regulation. Cellular Immunology. 39: 125-53. PMID 308845 DOI: 10.1016/0008-8749(78)90089-8  0.348
1978 Epstein R, Cohn M. T-cell inhibition of humoral responsiveness. I. Experimental evidence for restriction by the K- and/or D-end of the H-2 gene complex. Cellular Immunology. 39: 110-24. PMID 308844 DOI: 10.1016/0008-8749(78)90088-6  0.33
1977 Coffman RL, Cohn M. The class of surface immunoglobulin on virgin and memory B lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 118: 1806-15. PMID 67148  0.49
1977 Cohn M, Epstein R. Characterization of an inhibitory allogeneic effect on humoral responsiveness in vitro. Scandinavian Journal of Immunology. 6: 39-58. PMID 66739 DOI: 10.1111/J.1365-3083.1977.Tb00321.X  0.331
1977 Bevan MJ, Langman RE, Cohn M. H-2 antigen-specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequency. European Journal of Immunology. 6: 150-6. PMID 62665 DOI: 10.1002/Eji.1830060303  0.301
1976 Stallcup WB, Cohn M. Correlation of surface antigens and cell type in cloned cell lines from the rat central nervous system. Experimental Cell Research. 98: 285-297. PMID 56277 DOI: 10.1016/0014-4827(76)90440-7  0.306
1974 Kagnoff MF, Billings P, Cohn M. Functional characteristics of Peyer's patch lymphoid cells. II. Lipopolysaccharide is thymus dependent. The Journal of Experimental Medicine. 139: 407-13. PMID 4589992 DOI: 10.1084/Jem.139.2.407  0.332
1974 Ralph P, Hyman R, Epstein R, Nakoinz I, Cohn M. Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma. Biochemical and Biophysical Research Communications. 55: 1085-91. PMID 4358928 DOI: 10.1016/S0006-291X(73)80006-3  0.326
1974 Watson J, Epstein R, Cohn M. Cyclic nucleotides as intracellular mediators of the expression of antigen-sensitive cells. Nature. 246: 405-9. PMID 4357771 DOI: 10.1038/246405A0  0.337
1974 Barstad P, Farnsworth V, Weigert M, Cohn M, Hood L. Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes Proceedings of the National Academy of Sciences of the United States of America. 71: 4096-4100. PMID 4215076 DOI: 10.1073/Pnas.71.10.4096  0.55
1974 Weigert M, Raschke WC, Carson D, Cohn M. Immunochemical analysis of the idiotypes of mouse myeloma proteins with specificity for levan or dextran. The Journal of Experimental Medicine. 139: 137-47. PMID 4128444 DOI: 10.1084/Jem.139.1.137  0.556
1973 Watson J, Trenkner E, Cohn M. The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis. The Journal of Experimental Medicine. 138: 699-714. PMID 4737981 DOI: 10.1084/Jem.138.3.699  0.317
1973 Ralph P, Nakoinz I, Cohn M. Antibody dependent cellular immunity in newborn mice. Nature: New Biology. 245: 157-8. PMID 4517904 DOI: 10.1038/Newbio245157A0  0.337
1972 Lundblad A, Steller R, Kabat EA, Hirst JW, Weigert MG, Cohn M. Immunochemical studies on mouse myeloma proteins with specificity for dextran or for levan. Immunochemistry. 9: 535-44. PMID 5036150 DOI: 10.1016/0019-2791(72)90063-8  0.565
1972 Sher A, Cohn M. Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine European Journal of Immunology. 2: 319-326. PMID 4117282 DOI: 10.1002/Eji.1830020405  0.325
1971 Vicari G, Sher A, Cohn M, Kabat EA. Immunochemical studies on a mouse myeloma protein with specificity for certain beta-linked terminal residues of N-acetyl-D-glucosamine. Immunochemistry. 7: 829-38. PMID 4100095 DOI: 10.1016/0019-2791(70)90059-5  0.307
1970 Weigert MG, Cesari IM, Yonkovich SJ, Cohn M. Variability in the lambda light chain sequences of mouse antibody. Nature. 228: 1045-7. PMID 5483159 DOI: 10.1038/2281045A0  0.563
1968 Bretscher PA, Cohn M. Minimal model for the mechanism of antibody induction and paralysis by antigen Nature. 220: 444-448. PMID 5686155 DOI: 10.1038/220444A0  0.315
1965 Burstein C, Cohn M, Kepes A, Monod J. Rôle du lactose et de ses produits métaboliques dans l'induction de l'opéron lactose chez Escherichia coli Biochimica Et Biophysica Acta (Bba) - Nucleic Acids and Protein Synthesis. 95: 634-639. DOI: 10.1016/0005-2787(65)90517-4  0.651
1960 Cohn M, Lennox E, Spiegelman S. On the behavior of the E. coli Pz-"β-galactoside system" introduced into Shigella dysenteriae Bba - Biochimica Et Biophysica Acta. 39: 255-266. PMID 13811046 DOI: 10.1016/0006-3002(60)90162-1  0.625
1957 Cohn M. CONTRIBUTIONS OF STUDIES ON THE β-GALACTOSIDASE OF ESCHERICHIA COLI TO OUR UNDERSTANDING OF ENZYME SYNTHESIS Bacteriological Reviews. 21: 140-168. DOI: 10.1128/Mmbr.21.3.140-168.1957  0.309
1955 HOGNESS DS, COHN M, MONOD J. Studies on the induced synthesis of beta-galactosidase in Escherichia coli: the kinetics and mechanism of sulfur incorporation. Biochimica Et Biophysica Acta. 16: 99-116. PMID 14363236 DOI: 10.1016/0006-3002(55)90188-8  0.74
1953 COHN M, MONOD J, POLLOCK MR, SPIEGELMAN S, STANIER RY. Terminology of enzyme formation. Nature. 172: 1096. PMID 13111262 DOI: 10.1038/1721096A0  0.657
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