Robin John Leatherbarrow, BSc DPhil DSc - Publications

Vice-Chancellor's Office Liverpool John Moores University, Liverpool, England, United Kingdom 
Chemical Biology

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, ... Leatherbarrow RJ, et al. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nature Chemistry. PMID 29760414 DOI: 10.1038/s41557-018-0039-2  0.92
2017 Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW. Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm. 8: 191-197. PMID 28626547 DOI: 10.1039/c6md00531d  0.92
2015 Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. Medchemcomm. 6: 1767-1772. PMID 26962430 DOI: 10.1039/c5md00242g  0.92
2015 Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. Medchemcomm. 6: 1761-1766. PMID 26962429 DOI: 10.1039/c5md00241a  0.92
2015 Pitchford WH, Kim HJ, Ivanov AP, Kim HM, Yu JS, Leatherbarrow RJ, Albrecht T, Kim KB, Edel JB. Synchronized optical and electronic detection of biomolecules using a low noise nanopore platform. Acs Nano. 9: 1740-8. PMID 25635821 DOI: 10.1021/nn506572r  1
2015 Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase Medchemcomm. 6: 1767-1772. DOI: 10.1039/c5md00242g  1
2015 Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase Medchemcomm. 6: 1761-1766. DOI: 10.1039/c5md00241a  1
2014 Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF. Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. Plos Neglected Tropical Diseases. 8: e3363. PMID 25522361 DOI: 10.1371/journal.pntd.0003363  1
2014 Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors. Journal of Medicinal Chemistry. 57: 8664-70. PMID 25238611 DOI: 10.1021/jm5011397  1
2014 Olaleye TO, Brannigan JA, Roberts SM, Leatherbarrow RJ, Wilkinson AJ, Tate EW. Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites. Organic & Biomolecular Chemistry. 12: 8132-7. PMID 25230674 DOI: 10.1039/c4ob01669f  1
2014 Brannigan JA, Roberts SM, Bell AS, Hutton JA, Hodgkinson MR, Tate EW, Leatherbarrow RJ, Smith DF, Wilkinson AJ. Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors. Iucrj. 1: 250-60. PMID 25075346 DOI: 10.1107/S2052252514013001  1
2014 Gray K, Elghadban S, Thongyoo P, Owen KA, Szabo R, Bugge TH, Tate EW, Leatherbarrow RJ, Ellis V. Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II. Thrombosis and Haemostasis. 112: 402-11. PMID 24696092 DOI: 10.1160/TH13-11-0895  1
2014 Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). Journal of Medicinal Chemistry. 57: 2773-88. PMID 24641010 DOI: 10.1021/jm500066b  1
2014 Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, et al. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nature Chemistry. 6: 112-21. PMID 24451586 DOI: 10.1038/nchem.1830  1
2014 Roqué Rosell NR, Mokhlesi L, Milton NE, Sweeney TR, Zunszain PA, Curry S, Leatherbarrow RJ. Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease Bioorganic and Medicinal Chemistry Letters. 24: 490-494. PMID 24374278 DOI: 10.1016/j.bmcl.2013.12.045  1
2013 Smith LD, Leatherbarrow RJ, Spivey AC. Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies. Future Medicinal Chemistry. 5: 1423-35. PMID 23919552 DOI: 10.4155/fmc.13.112  1
2013 Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase. Journal of Medicinal Chemistry. 56: 371-5. PMID 23170970 DOI: 10.1021/jm301474t  1
2013 Sejberg JJP, Smith LD, Leatherbarrow RJ, Beavil AJ, Spivey AC. Enantioselective synthesis of (+)-aspercyclide A Tetrahedron Letters. 54: 4970-4972. DOI: 10.1016/j.tetlet.2013.07.038  1
2012 Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. Journal of Medicinal Chemistry. 55: 8879-90. PMID 23035716 DOI: 10.1021/jm301160h  1
2012 Elvira KS, Leatherbarrow R, Edel J, Demello A. Droplet dispensing in digital microfluidic devices: Assessment of long-term reproducibility. Biomicrofluidics. 6: 22003-2200310. PMID 22655007 DOI: 10.1063/1.3693592  1
2012 Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. Plos Neglected Tropical Diseases. 6: e1625. PMID 22545171 DOI: 10.1371/journal.pntd.0001625  1
2012 Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ. Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode. Journal of Medicinal Chemistry. 55: 3578-82. PMID 22439843 DOI: 10.1021/jm300040p  1
2012 Offermann DA, McKendrick JE, Sejberg JJ, Mo B, Holdom MD, Helm BA, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Spivey AC. Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE. The Journal of Organic Chemistry. 77: 3197-214. PMID 22397517 DOI: 10.1021/jo202604q  1
2012 Goncalves V, Brannigan JA, Thinon E, Olaleye TO, Serwa R, Lanzarone S, Wilkinson AJ, Tate EW, Leatherbarrow RJ. A fluorescence-based assay for N-myristoyltransferase activity. Analytical Biochemistry. 421: 342-4. PMID 22051857 DOI: 10.1016/j.ab.2011.10.013  1
2012 Bradshaw RT, Aronica PGA, Tate EW, Leatherbarrow RJ, Gould IR. Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein-protein interfaces Chemical Science. 3: 1503-1511. DOI: 10.1039/c2sc00895e  1
2011 Carr JL, Sejberg JJ, Saab F, Holdom MD, Davies AM, White AJ, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Lindell SD, Spivey AC. Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution. Organic & Biomolecular Chemistry. 9: 6814-24. PMID 21845261 DOI: 10.1039/c1ob05862b  1
2011 Stuart SF, Leatherbarrow RJ, Willison KR. A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin Journal of Biological Chemistry. 286: 178-184. PMID 21056978 DOI: 10.1074/jbc.M110.166256  1
2011 Bradshaw RT, Patel BH, Tate EW, Leatherbarrow RJ, Gould IR. Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction. Protein Engineering, Design & Selection : Peds. 24: 197-207. PMID 20656696 DOI: 10.1093/protein/gzq047  0.92
2010 So S, Peeva LG, Tate EW, Leatherbarrow RJ, Livingston AG. Membrane enhanced peptide synthesis. Chemical Communications (Cambridge, England). 46: 2808-10. PMID 20369190 DOI: 10.1039/b926747f  1
2010 Carr JL, Offermann DA, Holdom MD, Dusart P, White AJ, Beavil AJ, Leatherbarrow RJ, Lindell SD, Sutton BJ, Spivey AC. Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether. Chemical Communications (Cambridge, England). 46: 1824-6. PMID 20198221 DOI: 10.1039/b923528k  1
2010 Brannigan JA, Smith BA, Yu Z, Brzozowski AM, Hodgkinson MR, Maroof A, Price HP, Meier F, Leatherbarrow RJ, Tate EW, Smith DF, Wilkinson AJ. N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. Journal of Molecular Biology. 396: 985-99. PMID 20036251 DOI: 10.1016/j.jmb.2009.12.032  1
2010 Zunszain PA, Knox SR, Sweeney TR, Yang J, Roqué-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry S. Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate Journal of Molecular Biology. 395: 375-389. PMID 19883658 DOI: 10.1016/j.jmb.2009.10.048  1
2010 So S, Peeva LG, Tate EW, Leatherbarrow RJ, Livingston AG. Organic solvent nanofiltration: A new paradigm in peptide synthesis Organic Process Research and Development. 14: 1313-1325. DOI: 10.1021/op1001403  1
2009 Thongyoo P, Bonomelli C, Leatherbarrow RJ, Tate EW. Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold. Journal of Medicinal Chemistry. 52: 6197-200. PMID 19772295 DOI: 10.1021/jm901233u  1
2009 Srisa-Art M, Kang DK, Hong J, Park H, Leatherbarrow RJ, Edel JB, Chang SI, deMello AJ. Analysis of protein-protein interactions by using droplet-based microfluidics. Chembiochem : a European Journal of Chemical Biology. 10: 1605-11. PMID 19496107 DOI: 10.1002/cbic.200800841  1
2008 Busch GK, Tate EW, Gaffney PR, Rosivatz E, Woscholski R, Leatherbarrow RJ. Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation. Chemical Communications (Cambridge, England). 3369-71. PMID 18633492 DOI: 10.1039/b806727a  1
2008 Heal WP, Wickramasinghe SR, Leatherbarrow RJ, Tate EW. N-Myristoyl transferase-mediated protein labelling in vivo. Organic & Biomolecular Chemistry. 6: 2308-15. PMID 18563263 DOI: 10.1039/b803258k  1
2008 Thongyoo P, Roqué-Rosell N, Leatherbarrow RJ, Tate EW. Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides. Organic & Biomolecular Chemistry. 6: 1462-70. PMID 18385853 DOI: 10.1039/b801667d  1
2008 Bowyer PW, Tate EW, Leatherbarrow RJ, Holder AA, Smith DF, Brown KA. N-myristoyltransferase: a prospective drug target for protozoan parasites. Chemmedchem. 3: 402-8. PMID 18324715 DOI: 10.1002/cmdc.200700301  1
2008 Heal WP, Wickramasinghe SR, Bowyer PW, Holder AA, Smith DF, Leatherbarrow RJ, Tate EW. Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry. Chemical Communications (Cambridge, England). 480-2. PMID 18188474 DOI: 10.1039/b716115h  1
2007 Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF. Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. The Biochemical Journal. 408: 173-80. PMID 17714074 DOI: 10.1042/BJ20070692  1
2007 Jaulent AM, Fahy AS, Knox SR, Birtley JR, Roqué-Rosell N, Curry S, Leatherbarrow RJ. A continuous assay for foot-and-mouth disease virus 3C protease activity Analytical Biochemistry. 368: 130-137. PMID 17631855 DOI: 10.1016/j.ab.2007.05.026  1
2007 Thongyoo P, Jaulent AM, Tate EW, Leatherbarrow RJ. Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins. Chembiochem : a European Journal of Chemical Biology. 8: 1107-9. PMID 17526063 DOI: 10.1002/cbic.200700187  1
2007 Curry S, Roqué-Rosell N, Sweeney TR, Zunszain PA, Leatherbarrow RJ. Structural analysis of foot-and-mouth disease virus 3C protease: A viable target for antiviral drugs? Biochemical Society Transactions. 35: 594-598. PMID 17511659 DOI: 10.1042/BST0350594  1
2007 Brauer AB, McBride JD, Kelly G, Matthews SJ, Leatherbarrow RJ. Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds. Bioorganic & Medicinal Chemistry. 15: 4618-28. PMID 17470393 DOI: 10.1016/j.bmc.2007.03.082  1
2007 Sweeney TR, Roqué-Rosell N, Birtley JR, Leatherbarrow RJ, Curry S. Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis Journal of Virology. 81: 115-124. PMID 17065215 DOI: 10.1128/JVI.01587-06  1
2007 Curry S, Roqué-Rosell N, Zunszain PA, Leatherbarrow RJ. Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target International Journal of Biochemistry and Cell Biology. 39: 1-6. PMID 16979372 DOI: 10.1016/j.biocel.2006.07.006  1
2006 Thongyoo P, Tate EW, Leatherbarrow RJ. Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II. Chemical Communications (Cambridge, England). 2848-50. PMID 17007393 DOI: 10.1039/b607324g  1
2006 Panethymitaki C, Bowyer PW, Price HP, Leatherbarrow RJ, Brown KA, Smith DF. Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major Biochemical Journal. 396: 277-285. PMID 16480339 DOI: 10.1042/BJ20051886  1
2006 Tate EW, Bowyer PW, Brown KA, Smith DF, Holder AA, Leatherbarrow RJ. Peptide-based inhibitors of N-myristoyl transferase generated from a lipid/combinatorial peptide chimera library Signal Transduction. 6: 160-166. DOI: 10.1002/sita.200500084  1
2005 Jaulent AM, Brauer AB, Matthews SJ, Leatherbarrow RJ. Solution structure of a novel C2-symmetrical bifunctional bicyclic inhibitor based on SFTI-1 Journal of Biomolecular Nmr. 33: 57-62. PMID 16222558 DOI: 10.1007/s10858-005-1210-9  1
2005 Karp NA, Edwards PR, Leatherbarrow RJ. Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors Biosensors and Bioelectronics. 21: 128-134. PMID 15967360 DOI: 10.1016/j.bios.2004.08.027  1
2005 Birtley JR, Knox SR, Jaulent AM, Brick P, Leatherbarrow RJ, Curry S. Crystal structure of foot-and-mouth disease virus 3C protease: New insights into catalytic mechanism and cleavage specificity Journal of Biological Chemistry. 280: 11520-11527. PMID 15654079 DOI: 10.1074/jbc.M413254200  1
2004 Scarpi D, McBride JD, Leatherbarrow RJ. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor. Bioorganic & Medicinal Chemistry. 12: 6045-52. PMID 15519150 DOI: 10.1016/j.bmc.2004.09.015  1
2004 Jaulent AM, Leatherbarrow RJ. Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors Protein Engineering, Design and Selection. 17: 681-687. PMID 15486024 DOI: 10.1093/protein/gzh077  1
2004 Miles SM, Leatherbarrow RJ, Marsden SP, Coates WJ. Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues Organic and Biomolecular Chemistry. 2: 281-283. PMID 14747852 DOI: 10.1039/b312908j  1
2004 Miles SM, Marsden SP, Leatherbarrow RJ, Coates WJ. A novel, stereoselective and convergent synthesis of aryltetralins Chemical Communications. 10: 2292-2293. DOI: 10.1039/b409528f  1
2004 Miles SM, Marsden SP, Leatherbarrow RJ, Coates WJ. Reagent-controlled stereoselective synthesis of lignan-related tetrahydrofurans Journal of Organic Chemistry. 69: 6874-6882. DOI: 10.1021/jo048971a  1
2003 Brauer ABE, Leatherbarrow RJ. The conserved P1′ Ser of Bowman-Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop Biochemical and Biophysical Research Communications. 308: 300-305. PMID 12901868 DOI: 10.1016/S0006-291X(03)01365-2  1
2003 Brauer ABE, Nievo M, McBride JD, Leatherbarrow RJ. The structural basis of a conserved P2 threonine in canonical serine proteinase inhibitors Journal of Biomolecular Structure and Dynamics. 20: 645-655. PMID 12643767  1
2002 McBride JD, Watson EM, Brauer ABE, Jaulent AM, Leatherbarrow RJ. Peptide mimics of the Bowman-Birk inhibitor reactive site loop Biopolymers - Peptide Science Section. 66: 79-92. PMID 12325158 DOI: 10.1002/bip.10228  1
2002 Brauer ABE, Domingo GJ, Cooke RM, Matthews SJ, Leatherbarrow RJ. A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein Biochemistry. 41: 10608-10615. PMID 12186545 DOI: 10.1021/bi026050t  1
2002 Brauer ABE, Kelly G, Matthews SJ, Leatherbarrow RJ. The 1H-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: A minimal 'canonical loop' Journal of Biomolecular Structure and Dynamics. 20: 59-70. PMID 12144352  1
2002 Scarpi D, McBride JD, Leatherbarrow RJ. Inhibition of human β-tryptase by Bowman-Birk inhibitor derived peptides Journal of Peptide Research. 59: 90-93. PMID 11906611  1
2001 Scarpi D, Occhiato EG, Trabocchi A, Leatherbarrow RJ, Brauer ABE, Nievo M, Guarna A. Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: Synthesis and conformational analysis Bioorganic and Medicinal Chemistry. 9: 1625-1632. PMID 11408182 DOI: 10.1016/S0968-0896(01)00046-3  1
2001 McBride JD, Leatherbarrow RJ. Synthetic peptide mimics of the Bowman-Birk inhibitor protein Current Medicinal Chemistry. 8: 909-917. PMID 11375759  1
2001 Brauer ABE, Kelly G, McBride JD, Cooke RM, Matthews SJ, Leatherbarrow RJ. The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural β-hairpin motif Journal of Molecular Biology. 306: 799-807. PMID 11243789 DOI: 10.1006/jmbi.2000.4410  1
2000 Mcbride JD, Freeman HN, Leatherbarrow RJ. Identification of chymotrypsin inhibitors from a second-generation template assisted combinatorial peptide library Journal of Peptide Science. 6: 446-452. PMID 11016881 DOI: 10.1002/1099-1387(200009)6:9<446::AID-PSC283>3.0.CO;2-U  1
1999 McBride JD, Freeman HNM, Leatherbarrow RJ. Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library European Journal of Biochemistry. 266: 403-412. PMID 10561580 DOI: 10.1046/j.1432-1327.1999.00867.x  1
1999 Leatherbarrow RJ, Edwards PR. Analysis of molecular recognition using optical biosensors Current Opinion in Chemical Biology. 3: 544-547. PMID 10508667 DOI: 10.1016/S1367-5931(99)00006-X  1
1999 Gariani T, McBride JD, Leatherbarrow RJ. The role of the P2' position of Bowman-Birk proteinase inhibitor in the inhibition of trypsin: Studies on P2' variation in cyclic peptides encompassing the reactive site loop Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1431: 232-237. PMID 10209295 DOI: 10.1016/S0167-4838(99)00035-7  1
1999 McNee JJ, Wang F, Leatherbarrow RJ. Expression and Secretion of Biologically Active CMTI I in Saccharomyces cerevisiae Protein and Peptide Letters. 6: 351-358.  1
1998 Edwards PR, Maule CH, Leatherbarrow RJ, Winzor DJ. Second-order kinetic analysis of IAsys biosensor data: Its use and applicability Analytical Biochemistry. 263: 1-12. PMID 9750135 DOI: 10.1006/abio.1998.2814  1
1998 McBride JD, Brauer ABE, Nievo M, Leatherbarrow RJ. The role of threonine in the P2 position of Bowman-Birk proteinase inhibitors: Studies on P2 variation in cyclic peptides encompassing the reactive site loop Journal of Molecular Biology. 282: 447-457. PMID 9735299 DOI: 10.1006/jmbi.1998.2032  1
1998 Hasan Z, Leatherbarrow RJ. A study of the specificity of barley chymotrypsin inhibitor 2 by cysteine engineering of the P1 residue Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1384: 325-334. PMID 9659394 DOI: 10.1016/S0167-4838(98)00026-0  1
1998 Foord RL, Leatherbarrow RJ. Effect of osmolytes on the exchange rates of backbone amide protons in proteins Biochemistry. 37: 2969-2978. PMID 9485449 DOI: 10.1021/bi9712798  1
1997 Edwards PR, Lowe PA, Leatherbarrow RJ. Ligand loading at the surface of an optical biosensor and its effect upon the kinetics of protein-protein interactions Journal of Molecular Recognition. 10: 128-134. PMID 9408828  1
1997 Gariani T, Leatherbarrow RJ. Stability of protease inhibitors based on the Bowman-Birk reactive site loop to hydrolysis by proteases Journal of Peptide Research. 49: 467-475. PMID 9266473  1
1997 Edwards PR, Leatherbarrow RJ. Determination of association rate constants by an optical biosensor using initial rate analysis Analytical Biochemistry. 246: 1-6. DOI: 10.1006/abio.1996.9922  1
1997 Hasan Z, Leatherbarrow RJ. Introduction of trypsin specificity into chymotrypsin inhibitor II Protein and Peptide Letters. 4: 335-342.  1
1996 Gill A, Leatherbarrow RJ, Hoare M, Pollard-Knight DV, Lowe PA, Fortune DH. Analysis of kinetic data of antibody-antigen interaction from an optical biosensor by exponential curve fitting. Journal of Biotechnology. 48: 117-27. PMID 8818278 DOI: 10.1016/0168-1656(96)01410-1  1
1996 McBride JD, Freeman N, Domingo GJ, Leatherbarrow RJ. Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library Journal of Molecular Biology. 259: 819-827. PMID 8683585 DOI: 10.1006/jmbi.1996.0360  1
1996 Holmes DIR, Mantafounis D, Ward WHJ, Leatherbarrow RJ. Bacteriophage display of chymotrypsin inhibitor 2 Protein and Peptide Letters. 3: 415-422.  1
1996 McBride JD, Harbeck B, Leatherbarrow RJ. Resin-coupled cyclic peptides as proteinase inhibitors Protein and Peptide Letters. 3: 193-198.  1
1995 Edwards PR, Gill A, Pollard-Knight DV, Hoare M, Buckle PE, Lowe PA, Leatherbarrow RJ. Kinetics of protein-protein interactions at the surface of an optical biosensor. Analytical Biochemistry. 231: 210-7. PMID 8678303 DOI: 10.1006/abio.1995.1522  1
1995 Domingo GJ, Leatherbarrow RJ, Freeman N, Patel S, Weir M. Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to screen for serine protease inhibitors International Journal of Peptide and Protein Research. 46: 79-87. PMID 7558601  1
1994 Greagg MA, Brauer ABE, Leatherbarrow RJ. Expression and kinetic characterization of barley chymotrypsin inhibitors 1a and 1b Bba - Molecular Cell Research. 1222: 179-186. PMID 8031854 DOI: 10.1016/0167-4889(94)90167-8  1
1993 Matthews SJ, Jandu SK, Leatherbarrow RJ. 13C NMR study of the effects of mutation on the tryptophan dynamics in chymotrypsin inhibitor 2: Correlations with structure and stability Biochemistry. 32: 657-662. PMID 8422372  1
1993 Matthews SJ, Leatherbarrow RJ. The use of osmolytes to facilitate protein NMR spectroscopy Journal of Biomolecular Nmr. 3: 597-600. DOI: 10.1007/BF00174612  1
1992 Wells TNC, Stedman M, Leatherbarrow RJ. Imaging of proteins by scanning tunnelling microscopy Ultramicroscopy. 42: 1200-1203. PMID 1413259 DOI: 10.1016/0304-3991(92)90424-I  1
1991 Leatherbarrow RJ, Salacinski HJ. Design of a small peptide-based proteinase inhibitor by modeling the active-site region of barley chymotrypsin inhibitor 2 Biochemistry. 30: 10717-10721. PMID 1931991  1
1991 Leatherbarrow RJ, Stedman M, Wells TNC. Structure of immunoglobulin G by scanning tunnelling microscopy Journal of Molecular Biology. 221: 361-365. PMID 1920422 DOI: 10.1016/0022-2836(91)80056-Z  1
1991 Rudd PM, Leatherbarrow RJ, Rademacher TW, Dwek RA. Diversification of the IgG molecule by oligosaccharides. Molecular Immunology. 28: 1369-78. PMID 1749386 DOI: 10.1016/0161-5890(91)90039-M  1
1990 Garcia GA, Leatherbarrow RJ, Eckstein F, Fersht AR. Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction Biochemistry. 29: 1643-1648. PMID 2334722  1
1990 Leatherbarrow RJ. Use of nonlinear regression to analyze enzyme kinetic data: Application to situations of substrate contamination and background subtraction Analytical Biochemistry. 184: 274-278. PMID 2327571 DOI: 10.1016/0003-2697(90)90680-8  1
1990 Wang N, Southan C, DeWolf WE, Wells TN, Kruse LI, Leatherbarrow RJ. Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing. Biochemistry. 29: 6466-74. PMID 2207088  1
1990 Jandu SK, Ray S, Brooks L, Leatherbarrow RJ. Role of arginine 67 in the stabilization of chymotrypsin inhibitor 2: Examination of amide proton exchange rates and denaturation thermodynamics of an engineered protein Biochemistry. 29: 6264-6269. PMID 2207072 DOI: 10.1021/bi00478a022  1
1990 Self SJ, Hunter CN, Leatherbarrow RJ. Molecular cloning, sequencing and expression of cytochrome c2 from Rhodospirillum rubrum Biochemical Journal. 265: 599-604. PMID 2154194  1
1990 Leatherbarrow RJ. Using linear and non-linear regression to fit biochemical data Trends in Biochemical Sciences. 15: 455-458. PMID 2077683 DOI: 10.1016/0968-0004(90)90295-M  1
1990 Leatherbarrow RJ. On to the second generation Nature. 348: 482. DOI: 10.1038/348482a0  1
1989 Leatherbarrow RJ. Designer catalytic antibodies Nature. 338: 206-207. PMID 2922045  1
1988 Leatherbarrow RJ. Mouse + micro = molecular model. Alchemy™ Molecular modelling software for... Trends in Biochemical Sciences. 13: 188-189.  1
1987 Fersht AR, Leatherbarrow RJ, Wells TNC. Structure-activity relationships in engineered proteins: Analysis of use of binding energy by linear free energy relationships Biochemistry. 26: 6030-6038. PMID 3480005  1
1987 Leatherbarrow RJ, Fersht AR. Investigation of transition-state stabilization by residues histidine-45 and threonine-40 in the tyrosyl-tRNA synthetase Biochemistry. 26: 8524-8528. PMID 3126804  1
1986 Leatherbarrow RJ, Fersht AR. Protein engineering. Protein Engineering. 1: 7-16. PMID 3333843  1
1986 Fersht AR, Leatherbarrow RJ, Wells TNC. Quantitative analysis of structure-activity relationships in engineered proteins by linear free-energy relationships Nature. 322: 284-286. DOI: 10.1038/322284a0  1
1986 Fersht AR, Leatherbarrow RJ, Wells TNC. Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase Trends in Biochemical Sciences. 11: 321-325. DOI: 10.1016/0968-0004(86)90289-6  1
1985 Leatherbarrow RJ, Rademacher TW, Dwek RA, Woof JM, Clark A, Burton DR, Richardson N, Feinstein A. Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor. Molecular Immunology. 22: 407-15. PMID 4033665 DOI: 10.1016/0161-5890(85)90125-7  1
1985 Leatherbarrow RJ, Fersht AR, Winter G. Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering. Proceedings of the National Academy of Sciences of the United States of America. 82: 7840-4. PMID 3865201  1
1984 Leatherbarrow RJ, Dwek RA. Binding of complement subcomponent C1q to mouse IgG1, IgG2a and IgG2b: a novel C1q binding assay. Molecular Immunology. 21: 321-7. PMID 6610105 DOI: 10.1016/0161-5890(84)90103-2  1
1983 Leatherbarrow RJ, Dwek RA. The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A. Febs Letters. 164: 227-30. PMID 6653789 DOI: 10.1016/0014-5793(83)80290-7  1
1982 Leatherbarrow RJ, Jackson WR, Dwek RA. Role of tyrosines in the combining site of the dinitrophenyl-binding IgA myeloma M315: specific nitration and high-resolution hydrogen-1 nuclear magnetic resonance studies. Biochemistry. 21: 5124-9. PMID 7171542  1
1982 Gettins P, Pótter M, Leatherbarrow RJ, Dwek RA. A combined proton and phosphorus-31 nuclear magnetic resonance investigation of the combining site of M603, a phosphocholine-binding myeloma protein. Biochemistry. 21: 4927-31. PMID 6291593  1
1981 Jackson WR, Leatherbarrow RJ, Gavish M, Givol D, Dwek RA. Antibody specificity: a 270-MHz hydrogen-1 nuclear magnetic resonance study of the binding of dinitrophenyl compounds to the VL dimer of protein 315. Biochemistry. 20: 2339-45. PMID 7236605  1
1980 Leatherbarrow RJ, Dean PD. Studies on the mechanism of binding of serum albumins to immobilized cibacron blue F3G A. The Biochemical Journal. 189: 27-34. PMID 7458904  1
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