| Year |
Citation |
Score |
| 2024 |
Liu Z, Li S, Wang C, Vidmar KJ, Bracey S, Li L, Willard B, Miyagi M, Lan T, Dickinson BC, Osme A, Pizarro TT, Xiao TS. Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release. Proceedings of the National Academy of Sciences of the United States of America. 121: e2400883121. PMID 38980908 DOI: 10.1073/pnas.2400883121 |
0.459 |
|
| 2023 |
Busscher BM, Befekadu HB, Liu Z, Xiao TS. SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence. Viruses. 15. PMID 38005906 DOI: 10.3390/v15112229 |
0.408 |
|
| 2023 |
Li S, Bracey S, Liu Z, Xiao TS. Regulation of gasdermins in pyroptosis and cytokine release. Advances in Immunology. 158: 75-106. PMID 37453754 DOI: 10.1016/bs.ai.2023.03.002 |
0.432 |
|
| 2022 |
Li Y, Liu Z, Zhao Y, Yang J, Xiao TS, Conlon RA, Wang Z. PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain. Genes & Diseases. 10: 1702-1713. PMID 37397533 DOI: 10.1016/j.gendis.2022.11.003 |
0.427 |
|
| 2022 |
Xu Z, Deng S, Huang Y, Yang Y, Sun L, Liu H, Zhao D, Zeng W, Yin X, Zheng P, Wang Y, Liu M, Zhao W, Xiao TS, Zhou Y, et al. The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation. Frontiers in Immunology. 13: 1047922. PMID 36426349 DOI: 10.3389/fimmu.2022.1047922 |
0.538 |
|
| 2022 |
Basavarajappa SC, Liu AR, Bruchez A, Li Z, Suzart VG, Liu Z, Chen Y, Xiao TS, Buck M, Ramakrishnan P. Trimeric Receptor Binding Domain of SARS-CoV-2 Acts as a Potent Inhibitor of ACE2 Receptor-Mediated Viral Entry. Iscience. 104716. PMID 35813876 DOI: 10.1016/j.isci.2022.104716 |
0.443 |
|
| 2022 |
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, Zhang CJ, Zhao J, Zhang R, Liu C, Kang Z, Bermel RA, Dubyak G, Abbott DW, Xiao TS, et al. TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nature Communications. 13: 2406. PMID 35504893 DOI: 10.1038/s41467-022-30174-1 |
0.661 |
|
| 2021 |
Liu Z, Xiao TS. Partners with a killer: Metabolic signaling promotes inflammatory cell death. Cell. 184: 4374-4376. PMID 34416144 DOI: 10.1016/j.cell.2021.07.036 |
0.349 |
|
| 2021 |
Fan X, Jiang J, Zhao D, Chen F, Ma H, Smith P, Unterholzner L, Xiao TS, Jin T. Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Research. PMID 33619523 DOI: 10.1093/nar/gkab076 |
0.578 |
|
| 2020 |
Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, Xiao TS. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. PMID 32553275 DOI: 10.1016/J.Immuni.2020.06.007 |
0.688 |
|
| 2020 |
Srinivasan S, Liu Z, Chuenchor W, Xiao TS, Jankowsky E. Function of Auxiliary Domains of the DEAH/RHA Helicase DHX36 in RNA Remodeling. Journal of Molecular Biology. PMID 32087197 DOI: 10.1016/J.Jmb.2020.02.005 |
0.765 |
|
| 2020 |
Rathkey JK, Xiao TS, Abbott DW. Human polymorphisms in Gsdmd alter the inflammatory response. The Journal of Biological Chemistry. PMID 31988247 DOI: 10.1074/Jbc.Ra119.010604 |
0.546 |
|
| 2019 |
Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS. Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Immunity. PMID 31097341 DOI: 10.1016/J.Immuni.2019.04.017 |
0.741 |
|
| 2018 |
Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Science Immunology. 3. PMID 30143556 DOI: 10.1126/Sciimmunol.Aat2738 |
0.712 |
|
| 2018 |
Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891674 DOI: 10.1107/S0108767318095296 |
0.745 |
|
| 2018 |
Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T. Functional and Structural Characterization of Zebrafish ASC. The Febs Journal. PMID 29791979 DOI: 10.1111/Febs.14514 |
0.596 |
|
| 2018 |
Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS. Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure (London, England : 1993). PMID 29576317 DOI: 10.1016/J.Str.2018.03.002 |
0.764 |
|
| 2018 |
Jin T, Huang M, Jiang J, Smith P, Xiao TS. Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction. Plos One. 13: e0190547. PMID 29293680 DOI: 10.1371/Journal.Pone.0190547 |
0.591 |
|
| 2017 |
Yangyuoru PM, Bradburn DA, Liu Z, Xiao TS, Russell R. The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism. The Journal of Biological Chemistry. PMID 29269411 DOI: 10.1074/Jbc.M117.815076 |
0.397 |
|
| 2017 |
Perex JM, Xiao TS, Abbott DW. Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. The Journal of Biological Chemistry. PMID 29212706 DOI: 10.1074/Jbc.Ra117.000408 |
0.543 |
|
| 2017 |
Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW. Live cell visualization of gasdermin D-driven pyroptotic cell death. The Journal of Biological Chemistry. PMID 28726636 DOI: 10.1074/Jbc.M117.797217 |
0.672 |
|
| 2017 |
Jin T, Chuenchor W, Jiang J, Cheng J, Li Y, Fang K, Huang M, Smith P, Xiao TS. Design of an expression system to enhance MBP-mediated crystallization. Scientific Reports. 7: 40991. PMID 28112203 DOI: 10.1038/Srep40991 |
0.741 |
|
| 2016 |
Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E. RAGE Enhances TLR Responses through Binding and Internalization of RNA. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798148 DOI: 10.4049/Jimmunol.1502169 |
0.496 |
|
| 2016 |
Yang J, Liu Z, Xiao TS. Post-translational regulation of inflammasomes. Cellular & Molecular Immunology. PMID 27345727 DOI: 10.1038/Cmi.2016.29 |
0.493 |
|
| 2016 |
Waldhuber A, Snyder GA, Römmler F, Cirl C, Müller T, Xiao TS, Svanborg C, Miethke T. A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli. Pathogens (Basel, Switzerland). 5. PMID 26938564 DOI: 10.3390/Pathogens5010025 |
0.658 |
|
| 2015 |
Liu Z, Xiao TS. STRUCTURAL BIOLOGY. Assembling the wheel of death. Science (New York, N.Y.). 350: 376-7. PMID 26494742 DOI: 10.1126/science.aad3981 |
0.367 |
|
| 2015 |
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nature Immunology. 16: 1025-33. PMID 26343537 DOI: 10.1038/Ni.3267 |
0.429 |
|
| 2015 |
Xiao TS. The nucleic acid-sensing inflammasomes. Immunological Reviews. 265: 103-11. PMID 25879287 DOI: 10.1111/imr.12281 |
0.365 |
|
| 2015 |
Mistry P, Laird MH, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TS, Chauhan J, Fletcher S, Toshchakov VY, MacKerell AD, Vogel SN. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proceedings of the National Academy of Sciences of the United States of America. 112: 5455-60. PMID 25870276 DOI: 10.1073/Pnas.1422576112 |
0.655 |
|
| 2015 |
Jin T, Xiao TS. Activation and assembly of the inflammasomes through conserved protein domain families. Apoptosis : An International Journal On Programmed Cell Death. 20: 151-6. PMID 25398536 DOI: 10.1007/S10495-014-1053-5 |
0.571 |
|
| 2014 |
Chuenchor W, Jin T, Ravilious G, Xiao TS. Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization. Current Opinion in Immunology. 26: 14-20. PMID 24419035 DOI: 10.1016/J.Coi.2013.10.009 |
0.725 |
|
| 2014 |
Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, ... Xiao TS, et al. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. The Journal of Biological Chemistry. 289: 669-79. PMID 24275656 DOI: 10.1074/Jbc.M113.523407 |
0.689 |
|
| 2013 |
Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, Tengchuan J, Jin T, Laustsen A, Hansen K, Ostergaard L, Fitzgerald KA, Xiao TS, Mikkelsen JG, Mogensen TH, Paludan SR. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proceedings of the National Academy of Sciences of the United States of America. 110: E4571-80. PMID 24154727 DOI: 10.1073/Pnas.1311669110 |
0.454 |
|
| 2013 |
Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, ... ... Xiao TS, et al. RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. The Journal of Experimental Medicine. 210: 2447-63. PMID 24081950 DOI: 10.1084/Jem.20120201 |
0.486 |
|
| 2013 |
Jin T, Huang M, Smith P, Jiang J, Xiao TS. Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 855-60. PMID 23908027 DOI: 10.1107/S1744309113015558 |
0.605 |
|
| 2013 |
Jin T, Huang M, Smith P, Jiang J, Xiao TS. The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 482-7. PMID 23695559 DOI: 10.1107/S1744309113010075 |
0.557 |
|
| 2013 |
Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. Journal of Immunology (Baltimore, Md. : 1950). 190: 5216-25. PMID 23585680 DOI: 10.4049/Jimmunol.1300097 |
0.473 |
|
| 2013 |
Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS. Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 110: 6985-90. PMID 23569230 DOI: 10.1073/Pnas.1215770110 |
0.666 |
|
| 2013 |
Jin T, Perry A, Smith P, Jiang J, Xiao TS. Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. The Journal of Biological Chemistry. 288: 13225-35. PMID 23530044 DOI: 10.1074/Jbc.M113.468033 |
0.518 |
|
| 2013 |
Jin T, Curry J, Smith P, Jiang J, Xiao TS. Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1. Proteins. 81: 1266-70. PMID 23508996 DOI: 10.1002/Prot.24287 |
0.605 |
|
| 2013 |
Jin T, Jiang J, Smith P, Xiao TS. 132 Cytokine. 63: 274. DOI: 10.1016/J.Cyto.2013.06.135 |
0.475 |
|
| 2012 |
Mu R, Dussupt V, Jiang J, Sette P, Rudd V, Chuenchor W, Bello NF, Bouamr F, Xiao TS. Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B. Structure (London, England : 1993). 20: 887-98. PMID 22484091 DOI: 10.1016/J.Str.2012.03.001 |
0.744 |
|
| 2012 |
Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 36: 561-71. PMID 22483801 DOI: 10.1016/J.Immuni.2012.02.014 |
0.537 |
|
| 2012 |
Xiao TS, Ting JP. NLRX1 has a tail to tell. Immunity. 36: 311-2. PMID 22444625 DOI: 10.1016/j.immuni.2012.03.002 |
0.321 |
|
| 2011 |
Sette P, Mu R, Dussupt V, Jiang J, Snyder G, Smith P, Xiao TS, Bouamr F. The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release. Structure (London, England : 1993). 19: 1485-95. PMID 21889351 DOI: 10.1016/J.Str.2011.07.016 |
0.763 |
|
| 2010 |
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology. 11: 997-1004. PMID 20890285 DOI: 10.1038/Ni.1932 |
0.46 |
|
| 2010 |
Xiao TS. Subversion of innate immune signaling through molecular mimicry Journal of Clinical Immunology. 30: 638-642. PMID 20589422 DOI: 10.1007/s10875-010-9435-0 |
0.369 |
|
| 2009 |
Xiao T. Innate immune recognition of nucleic acids Immunologic Research. 43: 98-108. PMID 18810334 DOI: 10.1007/s12026-008-8053-x |
0.338 |
|
| 2008 |
Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Molecular Cell. 32: 849-61. PMID 19111664 DOI: 10.1016/J.Molcel.2008.11.018 |
0.415 |
|
| 2008 |
Springer TA, Zhu J, Xiao T. Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 182: 791-800. PMID 18710925 DOI: 10.1083/Jcb.200801146 |
0.407 |
|
| 2004 |
Xie C, Shimaoka M, Xiao T, Schwab P, Klickstein LB, Springer TA. The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 15422-7. PMID 15494438 DOI: 10.1073/pnas.0406680101 |
0.446 |
|
| 2004 |
Chen J, Takagi J, Xie C, Xiao T, Luo BH, Springer TA. The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. The Journal of Biological Chemistry. 279: 55556-61. PMID 15448154 DOI: 10.1074/jbc.M407773200 |
0.467 |
|
| 2004 |
Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature. 432: 59-67. PMID 15378069 DOI: 10.1038/Nature02976 |
0.512 |
|
| 2003 |
Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell. 112: 99-111. PMID 12526797 DOI: 10.1016/S0092-8674(02)01257-6 |
0.62 |
|
| 2002 |
Shimaoka M, Lu C, Salas A, Xiao T, Takagi J, Springer TA. Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proceedings of the National Academy of Sciences of the United States of America. 99: 16737-41. PMID 12466503 DOI: 10.1073/pnas.252633099 |
0.49 |
|
| 2002 |
Xiao T, Gardner KH, Sprang SR. Cosolvent-induced transformation of a death domain tertiary structure. Proceedings of the National Academy of Sciences of the United States of America. 99: 11151-6. PMID 12177432 DOI: 10.1073/Pnas.172188399 |
0.729 |
|
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