☰

Tsan Sam Xiao - Publications

Affiliations: 
1995-2001 University of Texas Southwestern Medical Center, Dallas, TX, United States 
 2001-2006 Harvard Medical School, Boston, MA, United States 
 2006-2014 National Institutes of Health, National Institute of Allergy and Infectious Diseases 
 2014- Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Inflammasome, pyroptosis, innate immunity
Website:
https://case.edu/medicine/pathology/faculty/tsan-sam-xiao
Tree Info Similar researchers PubMed Report error

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Busscher BM, Befekadu HB, Liu Z, Xiao TS. SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence. Viruses. 15. PMID 38005906 DOI: 10.3390/v15112229  0.413
2023 Li S, Bracey S, Liu Z, Xiao TS. Regulation of gasdermins in pyroptosis and cytokine release. Advances in Immunology. 158: 75-106. PMID 37453754 DOI: 10.1016/bs.ai.2023.03.002  0.436
2022 Li Y, Liu Z, Zhao Y, Yang J, Xiao TS, Conlon RA, Wang Z. PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain. Genes & Diseases. 10: 1702-1713. PMID 37397533 DOI: 10.1016/j.gendis.2022.11.003  0.435
2022 Xu Z, Deng S, Huang Y, Yang Y, Sun L, Liu H, Zhao D, Zeng W, Yin X, Zheng P, Wang Y, Liu M, Zhao W, Xiao TS, Zhou Y, et al. The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation. Frontiers in Immunology. 13: 1047922. PMID 36426349 DOI: 10.3389/fimmu.2022.1047922  0.539
2022 Basavarajappa SC, Liu AR, Bruchez A, Li Z, Suzart VG, Liu Z, Chen Y, Xiao TS, Buck M, Ramakrishnan P. Trimeric Receptor Binding Domain of SARS-CoV-2 Acts as a Potent Inhibitor of ACE2 Receptor-Mediated Viral Entry. Iscience. 104716. PMID 35813876 DOI: 10.1016/j.isci.2022.104716  0.448
2022 Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, Zhang CJ, Zhao J, Zhang R, Liu C, Kang Z, Bermel RA, Dubyak G, Abbott DW, Xiao TS, et al. TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nature Communications. 13: 2406. PMID 35504893 DOI: 10.1038/s41467-022-30174-1  0.664
2021 Liu Z, Xiao TS. Partners with a killer: Metabolic signaling promotes inflammatory cell death. Cell. 184: 4374-4376. PMID 34416144 DOI: 10.1016/j.cell.2021.07.036  0.354
2021 Fan X, Jiang J, Zhao D, Chen F, Ma H, Smith P, Unterholzner L, Xiao TS, Jin T. Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Research. PMID 33619523 DOI: 10.1093/nar/gkab076  0.58
2020 Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, Xiao TS. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. PMID 32553275 DOI: 10.1016/J.Immuni.2020.06.007  0.691
2020 Srinivasan S, Liu Z, Chuenchor W, Xiao TS, Jankowsky E. Function of Auxiliary Domains of the DEAH/RHA Helicase DHX36 in RNA Remodeling. Journal of Molecular Biology. PMID 32087197 DOI: 10.1016/J.Jmb.2020.02.005  0.765
2020 Rathkey JK, Xiao TS, Abbott DW. Human polymorphisms in Gsdmd alter the inflammatory response. The Journal of Biological Chemistry. PMID 31988247 DOI: 10.1074/Jbc.Ra119.010604  0.548
2019 Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS. Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Immunity. PMID 31097341 DOI: 10.1016/J.Immuni.2019.04.017  0.745
2018 Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Science Immunology. 3. PMID 30143556 DOI: 10.1126/Sciimmunol.Aat2738  0.714
2018 Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891674 DOI: 10.1107/S0108767318095296  0.747
2018 Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T. Functional and Structural Characterization of Zebrafish ASC. The Febs Journal. PMID 29791979 DOI: 10.1111/Febs.14514  0.598
2018 Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS. Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure (London, England : 1993). PMID 29576317 DOI: 10.1016/J.Str.2018.03.002  0.766
2018 Jin T, Huang M, Jiang J, Smith P, Xiao TS. Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction. Plos One. 13: e0190547. PMID 29293680 DOI: 10.1371/Journal.Pone.0190547  0.592
2017 Yangyuoru PM, Bradburn DA, Liu Z, Xiao TS, Russell R. The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism. The Journal of Biological Chemistry. PMID 29269411 DOI: 10.1074/Jbc.M117.815076  0.401
2017 Perex JM, Xiao TS, Abbott DW. Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. The Journal of Biological Chemistry. PMID 29212706 DOI: 10.1074/Jbc.Ra117.000408  0.545
2017 Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW. Live cell visualization of gasdermin D-driven pyroptotic cell death. The Journal of Biological Chemistry. PMID 28726636 DOI: 10.1074/Jbc.M117.797217  0.674
2017 Jin T, Chuenchor W, Jiang J, Cheng J, Li Y, Fang K, Huang M, Smith P, Xiao TS. Design of an expression system to enhance MBP-mediated crystallization. Scientific Reports. 7: 40991. PMID 28112203 DOI: 10.1038/Srep40991  0.742
2016 Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E. RAGE Enhances TLR Responses through Binding and Internalization of RNA. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798148 DOI: 10.4049/Jimmunol.1502169  0.498
2016 Yang J, Liu Z, Xiao TS. Post-translational regulation of inflammasomes. Cellular & Molecular Immunology. PMID 27345727 DOI: 10.1038/Cmi.2016.29  0.498
2016 Waldhuber A, Snyder GA, Römmler F, Cirl C, Müller T, Xiao TS, Svanborg C, Miethke T. A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli. Pathogens (Basel, Switzerland). 5. PMID 26938564 DOI: 10.3390/Pathogens5010025  0.659
2015 Liu Z, Xiao TS. STRUCTURAL BIOLOGY. Assembling the wheel of death. Science (New York, N.Y.). 350: 376-7. PMID 26494742 DOI: 10.1126/science.aad3981  0.372
2015 Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nature Immunology. 16: 1025-33. PMID 26343537 DOI: 10.1038/Ni.3267  0.43
2015 Xiao TS. The nucleic acid-sensing inflammasomes. Immunological Reviews. 265: 103-11. PMID 25879287 DOI: 10.1111/imr.12281  0.365
2015 Mistry P, Laird MH, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TS, Chauhan J, Fletcher S, Toshchakov VY, MacKerell AD, Vogel SN. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proceedings of the National Academy of Sciences of the United States of America. 112: 5455-60. PMID 25870276 DOI: 10.1073/Pnas.1422576112  0.656
2015 Jin T, Xiao TS. Activation and assembly of the inflammasomes through conserved protein domain families. Apoptosis : An International Journal On Programmed Cell Death. 20: 151-6. PMID 25398536 DOI: 10.1007/S10495-014-1053-5  0.572
2014 Chuenchor W, Jin T, Ravilious G, Xiao TS. Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization. Current Opinion in Immunology. 26: 14-20. PMID 24419035 DOI: 10.1016/J.Coi.2013.10.009  0.725
2014 Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, ... Xiao TS, et al. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. The Journal of Biological Chemistry. 289: 669-79. PMID 24275656 DOI: 10.1074/Jbc.M113.523407  0.69
2013 Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, Tengchuan J, Jin T, Laustsen A, Hansen K, Ostergaard L, Fitzgerald KA, Xiao TS, Mikkelsen JG, Mogensen TH, Paludan SR. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proceedings of the National Academy of Sciences of the United States of America. 110: E4571-80. PMID 24154727 DOI: 10.1073/Pnas.1311669110  0.455
2013 Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, ... ... Xiao TS, et al. RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. The Journal of Experimental Medicine. 210: 2447-63. PMID 24081950 DOI: 10.1084/Jem.20120201  0.488
2013 Jin T, Huang M, Smith P, Jiang J, Xiao TS. Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 855-60. PMID 23908027 DOI: 10.1107/S1744309113015558  0.606
2013 Jin T, Huang M, Smith P, Jiang J, Xiao TS. The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 482-7. PMID 23695559 DOI: 10.1107/S1744309113010075  0.558
2013 Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. Journal of Immunology (Baltimore, Md. : 1950). 190: 5216-25. PMID 23585680 DOI: 10.4049/Jimmunol.1300097  0.475
2013 Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS. Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 110: 6985-90. PMID 23569230 DOI: 10.1073/Pnas.1215770110  0.667
2013 Jin T, Perry A, Smith P, Jiang J, Xiao TS. Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. The Journal of Biological Chemistry. 288: 13225-35. PMID 23530044 DOI: 10.1074/Jbc.M113.468033  0.519
2013 Jin T, Curry J, Smith P, Jiang J, Xiao TS. Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1. Proteins. 81: 1266-70. PMID 23508996 DOI: 10.1002/Prot.24287  0.606
2013 Jin T, Jiang J, Smith P, Xiao TS. 132 Cytokine. 63: 274. DOI: 10.1016/J.Cyto.2013.06.135  0.476
2012 Mu R, Dussupt V, Jiang J, Sette P, Rudd V, Chuenchor W, Bello NF, Bouamr F, Xiao TS. Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B. Structure (London, England : 1993). 20: 887-98. PMID 22484091 DOI: 10.1016/J.Str.2012.03.001  0.744
2012 Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 36: 561-71. PMID 22483801 DOI: 10.1016/J.Immuni.2012.02.014  0.538
2012 Xiao TS, Ting JP. NLRX1 has a tail to tell. Immunity. 36: 311-2. PMID 22444625 DOI: 10.1016/j.immuni.2012.03.002  0.322
2011 Sette P, Mu R, Dussupt V, Jiang J, Snyder G, Smith P, Xiao TS, Bouamr F. The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release. Structure (London, England : 1993). 19: 1485-95. PMID 21889351 DOI: 10.1016/J.Str.2011.07.016  0.763
2010 Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology. 11: 997-1004. PMID 20890285 DOI: 10.1038/Ni.1932  0.462
2010 Xiao TS. Subversion of innate immune signaling through molecular mimicry Journal of Clinical Immunology. 30: 638-642. PMID 20589422 DOI: 10.1007/s10875-010-9435-0  0.369
2009 Xiao T. Innate immune recognition of nucleic acids Immunologic Research. 43: 98-108. PMID 18810334 DOI: 10.1007/s12026-008-8053-x  0.338
2008 Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Molecular Cell. 32: 849-61. PMID 19111664 DOI: 10.1016/J.Molcel.2008.11.018  0.416
2008 Springer TA, Zhu J, Xiao T. Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 182: 791-800. PMID 18710925 DOI: 10.1083/Jcb.200801146  0.407
2004 Xie C, Shimaoka M, Xiao T, Schwab P, Klickstein LB, Springer TA. The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 15422-7. PMID 15494438 DOI: 10.1073/pnas.0406680101  0.447
2004 Chen J, Takagi J, Xie C, Xiao T, Luo BH, Springer TA. The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. The Journal of Biological Chemistry. 279: 55556-61. PMID 15448154 DOI: 10.1074/jbc.M407773200  0.467
2004 Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature. 432: 59-67. PMID 15378069 DOI: 10.1038/Nature02976  0.513
2003 Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell. 112: 99-111. PMID 12526797 DOI: 10.1016/S0092-8674(02)01257-6  0.622
2002 Shimaoka M, Lu C, Salas A, Xiao T, Takagi J, Springer TA. Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proceedings of the National Academy of Sciences of the United States of America. 99: 16737-41. PMID 12466503 DOI: 10.1073/pnas.252633099  0.491
2002 Xiao T, Gardner KH, Sprang SR. Cosolvent-induced transformation of a death domain tertiary structure. Proceedings of the National Academy of Sciences of the United States of America. 99: 11151-6. PMID 12177432 DOI: 10.1073/Pnas.172188399  0.729
Show low-probability matches.