| Year |
Citation |
Score |
| 2023 |
Zhou B, Abbott DW. Chemical modulation of gasdermin D activity: Therapeutic implications and consequences. Seminars in Immunology. 70: 101845. PMID 37806032 DOI: 10.1016/j.smim.2023.101845 |
0.32 |
|
| 2022 |
Zhou B, Ryder CB, Dubyak GR, Abbott DW. Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies. Science Signaling. 15: eabl6781. PMID 36538593 DOI: 10.1126/scisignal.abl6781 |
0.314 |
|
| 2022 |
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, Zhang CJ, Zhao J, Zhang R, Liu C, Kang Z, Bermel RA, Dubyak G, Abbott DW, Xiao TS, et al. TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nature Communications. 13: 2406. PMID 35504893 DOI: 10.1038/s41467-022-30174-1 |
0.603 |
|
| 2020 |
Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, Xiao TS. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. PMID 32553275 DOI: 10.1016/J.Immuni.2020.06.007 |
0.635 |
|
| 2020 |
Rathkey JK, Xiao TS, Abbott DW. Human polymorphisms in Gsdmd alter the inflammatory response. The Journal of Biological Chemistry. PMID 31988247 DOI: 10.1074/Jbc.Ra119.010604 |
0.615 |
|
| 2019 |
Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS. Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Immunity. PMID 31097341 DOI: 10.1016/J.Immuni.2019.04.017 |
0.622 |
|
| 2018 |
Zhang CJ, Jiang M, Zhou H, Liu W, Wang C, Kang Z, Han B, Zhang Q, Chen X, Xiao J, Fisher A, Kaiser WJ, Murayama MA, Iwakura Y, Gao J, ... ... Abbott DW, et al. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. The Journal of Clinical Investigation. PMID 30372424 DOI: 10.1172/Jci121901 |
0.314 |
|
| 2018 |
Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Science Immunology. 3. PMID 30143556 DOI: 10.1126/Sciimmunol.Aat2738 |
0.648 |
|
| 2018 |
Chirieleison SM, Rathkey JK, Abbott DW. Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Science Signaling. 11. PMID 30018081 DOI: 10.1126/scisignal.aao3964 |
0.366 |
|
| 2018 |
Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891674 DOI: 10.1107/S0108767318095296 |
0.657 |
|
| 2018 |
Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS. Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Structure (London, England : 1993). PMID 29576317 DOI: 10.1016/J.Str.2018.03.002 |
0.628 |
|
| 2017 |
Perex JM, Xiao TS, Abbott DW. Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. The Journal of Biological Chemistry. PMID 29212706 DOI: 10.1074/Jbc.Ra117.000408 |
0.584 |
|
| 2017 |
Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW. Live cell visualization of gasdermin D-driven pyroptotic cell death. The Journal of Biological Chemistry. PMID 28726636 DOI: 10.1074/Jbc.M117.797217 |
0.634 |
|
| 2017 |
Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. The Journal of Biological Chemistry. PMID 28404814 DOI: 10.1074/Jbc.M117.781500 |
0.362 |
|
| 2016 |
De Salvo C, Wang XM, Pastorelli L, Mattioli B, Omenetti S, Buela KA, Chowdhry S, Garg RR, Goodman WA, Rodriguez-Palacios A, Smith DE, Abbott DW, Cominelli F, Bamias G, Xin W, et al. IL-33 Interleukin-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis. The American Journal of Pathology. PMID 26908008 DOI: 10.1016/J.Ajpath.2015.11.028 |
0.327 |
|
| 2015 |
Cominelli CL, Wang X, Pizarro TT, Abbott D. 18 NOD2-Dependent IL-33 Expression Is an Important Mechanism in the Pathogenesis of Inflammatory Bowel Disease (IBD) Gastroenterology. 148: S-7. DOI: 10.1016/S0016-5085(15)30018-4 |
0.371 |
|
| 2014 |
Tigno-Aranjuez JT, Benderitter P, Rombouts F, Deroose F, Bai X, Mattioli B, Cominelli F, Pizarro TT, Hoflack J, Abbott DW. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. The Journal of Biological Chemistry. 289: 29651-64. PMID 25213858 DOI: 10.1074/Jbc.M114.591388 |
0.364 |
|
| 2012 |
Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, Morrice N, Abbott D, Ley SC. IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Molecular and Cellular Biology. 32: 4684-90. PMID 22988300 DOI: 10.1128/Mcb.01065-12 |
0.311 |
|
| 2008 |
Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/Nchembio.83 |
0.399 |
|
| 2007 |
Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. The Journal of Biological Chemistry. 282: 36223-9. PMID 17947236 DOI: 10.1074/Jbc.M703079200 |
0.356 |
|
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