Amnon Kohen, D. Sc. - Publications

Affiliations: 
Chemistry University of Iowa, Iowa City, IA 
Area:
Enzyme Catalysis
Website:
http://www.chem.uiowa.edu/kohen-research-group

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ranasinghe C, Pagano PL, Sapienza PJ, Lee AL, Kohen A, Cheatum CM. Isotopic Labeling of Formate Dehydrogenase Perturbs the Protein Dynamics. The Journal of Physical Chemistry. B. PMID 31696711 DOI: 10.1021/acs.jpcb.9b08426  1
2019 Li J, Fortunato G, Lin J, Agarwal PK, Kohen A, Singh P, Cheatum CM. Evolution Conserves the Network of Coupled Residues in Dihydrofolate Reductase. Biochemistry. PMID 31423766 DOI: 10.1021/acs.biochem.9b00460  1
2019 Pang S, Li X, Wu D, Li H, Wang X. Tuning inflammation response via adjusting microstructure of hydroxyapatite and biomolecules modification. Colloids and Surfaces. B, Biointerfaces. 177: 496-505. PMID 30807964 DOI: 10.1016/j.colsurfb.2019.02.026  0.36
2019 Bai L, Tao F, Li L, Deng A, Yan C, Li G, Wang L. A simple turn-on fluorescent chemosensor based on Schiff base-terminated water-soluble polymer for selective detection of Al in 100% aqueous solution. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 214: 436-444. PMID 30807941 DOI: 10.1016/j.saa.2019.02.062  0.52
2019 Kadam-Halani PK, Lee DD, Sammel MD, Arya LA, Andy UU. The Quality of Health Information Available on the Internet for Patients With Fecal Incontinence. Female Pelvic Medicine & Reconstructive Surgery. 25: 120-124. PMID 30807412 DOI: 10.1097/SPV.0000000000000658  0.36
2019 Ren S, Li C, Tan Z, Hou Y, Jia S, Cui J. Carbonic anhydrase-embedded ZIF-8 hydrogel membrane with improved the recycling and stability for efficient CO2 capture. Journal of Agricultural and Food Chemistry. PMID 30807136 DOI: 10.1021/acs.jafc.8b06182  0.4
2019 Cheng B, Cheng R, Tan F, Liu X, Huo J, Yue G. Highly Efficient Quasi-Solid-State Asymmetric Supercapacitors Based on MoS/MWCNT and PANI/MWCNT Composite Electrodes. Nanoscale Research Letters. 14: 66. PMID 30806819 DOI: 10.1186/s11671-019-2902-5  0.52
2019 Zhang S, Sun H, Wang C, Zheng X, Jia X, Cai E, Zhao Y. Comparative analysis of active ingredients and effects of the combination of Panax ginseng and Ophiopogon japonicus at different proportions on chemotherapy-induced myelosuppression mouse. Food & Function. PMID 30806385 DOI: 10.1039/c8fo02354a  0.36
2019 Liu F, Zhou R, Jiang F, Liu G, Li K, Zhu G. Proposal of a Nomogram for Predicting Survival in Patients with Siewert Type II Adenocarcinoma of the Esophagogastric Junction After Preoperative Radiation. Annals of Surgical Oncology. PMID 30805805 DOI: 10.1245/s10434-019-07237-7  0.4
2019 Li X, Wang Z, Xia H. Ultrasound Reversible Response Nanocarrier Based on Sodium Alginate Modified Mesoporous Silica Nanoparticles. Frontiers in Chemistry. 7: 59. PMID 30805332 DOI: 10.3389/fchem.2019.00059  0.52
2019 Nam HS, Choi CW, Kim SJ, Kim HW, Kang DH, Park SB, Ryu DG. Risk factors for delayed bleeding by onset time after endoscopic submucosal dissection for gastric neoplasm. Scientific Reports. 9: 2674. PMID 30804386 DOI: 10.1038/s41598-019-39381-1  0.32
2019 Zhang N, Zhao Y, Shi Y, Chen R, Fu X, Zhao Y. Polypeptides extracted from Eupolyphaga sinensis walker via enzymic digestion alleviate UV radiation-induced skin photoaging. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 112: 108636. PMID 30802824 DOI: 10.1016/j.biopha.2019.108636  0.52
2019 Wang L, Zhang S, Keatch R, Corner G, Nabi G, Murdoch S, Davidson F, Zhao Q. In vitro antibacterial and anti-encrustation performances of silver-polytetrafluoroethylene nanocomposite coated urinary catheter. The Journal of Hospital Infection. PMID 30802524 DOI: 10.1016/j.jhin.2019.02.012  0.36
2019 Liu P, Gu Y, Luo J, Ye P, Zheng Y, Yu W, Chen S. Inhibition of Src activation reverses pulmonary vascular remodeling in experimental pulmonary arterial hypertension via Akt/mTOR/HIF-1 signaling pathway. Experimental Cell Research. PMID 30802452 DOI: 10.1016/j.yexcr.2019.02.022  0.4
2019 Shen ZD, Yu HM, Wang JT, Shi GY, Sun Y. [Modified Western Ontario and McMaster University Osteoarthritis Index Scale used in patients with knee osteoarthritis]. Zhonghua Yi Xue Za Zhi. 99: 537-541. PMID 30786353 DOI: 10.3760/cma.j.issn.0376-2491.2019.07.012  0.6
2019 Tian Y, Luo GH, Yang XS, Xia SJ, Sun ZL. [Comparative observation of thulium laser resection of the prostate-tangerine technique and transurethral resection of the prostate for the treatment of benign prostatic hyperplasia of various sizes]. Zhonghua Yi Xue Za Zhi. 99: 423-427. PMID 30786335 DOI: 10.3760/cma.j.issn.0376-2491.2019.06.008  0.4
2019 Zhang FR, Lu JY, Yao QF, Zhu QY, Zhang XX, Huang WT, Xia LQ, Ding XZ. Matter, energy and information network of a graphene-peptide-based fluorescent sensing system for molecular logic computing, detection and imaging of cancer stem cell marker CD133 in cells and tumor tissues. The Analyst. PMID 30785136 DOI: 10.1039/c8an02115e  0.32
2019 Fang H, Huang PC, Wu FY. A highly sensitive fluorescent probe with different responses to Cu and Zn. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 214: 233-238. PMID 30785042 DOI: 10.1016/j.saa.2019.02.007  0.4
2019 Huang N, Wang WL, Xu ZB, Wu QY, Hu HY. UV/chlorine oxidation of the phosphonate antiscalant 1-Hydroxyethane-1, 1-diphosphonic acid (HEDP) used for reverse osmosis processes: Organic phosphorus removal and scale inhibition properties changes. Journal of Environmental Management. 237: 180-186. PMID 30784866 DOI: 10.1016/j.jenvman.2019.02.055  0.56
2019 Zhang Q, Xue D, Liu X, Gong X, Gao H. Process analysis of PM pollution events in a coastal city of China using CMAQ. Journal of Environmental Sciences (China). 79: 225-238. PMID 30784445 DOI: 10.1016/j.jes.2018.09.007  0.36
2019 Liu J, Guo D, Fan Y, Sun J, Cheng J, Shi Y. Experimental study on the antioxidant activity of Malus hupehensis (Pamp.) Rehd extracts in vitro and in vivo. Journal of Cellular Biochemistry. PMID 30784120 DOI: 10.1002/jcb.28469  0.36
2019 Guo WL, Geng J, Zhan Y, Tan YL, Hu ZC, Pan P, Sheng M, Wang J, Huang SG. Forecasting and predicting intussusception in children younger than 48 months in Suzhou using a seasonal autoregressive integrated moving average model. Bmj Open. 9: e024712. PMID 30782741 DOI: 10.1136/bmjopen-2018-024712  0.32
2019 Zhao L, Pang P, Zang L, Luo Y, Wang F, Yang G, Du J, Wang X, Lyu Z, Dou J, Mu Y. Features and trends of thyroid cancer in patients with thyroidectomies in Beijing, China between 1994 and 2015: a retrospective study. Bmj Open. 9: e023334. PMID 30782703 DOI: 10.1136/bmjopen-2018-023334  0.52
2019 Zhang X, Wang WY, Zhang K, Tian J, Zheng JL, Chen J, An SM, Wang SY, Liu YP, Zhao Y, Wang JJ, Yang M, Tang YD. Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF). Trials. 20: 143. PMID 30782213 DOI: 10.1186/s13063-019-3219-5  0.52
2019 Wang H, Ye X, Zhou J. Self-Assembly Fluorescent Cationic Cellulose Nanocomplex via Electrostatic Interaction for the Detection of Fe Ions. Nanomaterials (Basel, Switzerland). 9. PMID 30781532 DOI: 10.3390/nano9020279  0.52
2019 Yao N, Huang ZG, Ren HP, Grebogi C, Lai YC. Self-adaptation of chimera states. Physical Review. E. 99: 010201. PMID 30780345 DOI: 10.1103/PhysRevE.99.010201  0.32
2019 Bairagi N, Saha S, Chaudhuri S, Dana SK. Zooplankton selectivity and nutritional value of phytoplankton influences a rich variety of dynamics in a plankton population model. Physical Review. E. 99: 012406. PMID 30780343 DOI: 10.1103/PhysRevE.99.012406  0.36
2019 Dymarsky A, Liu H. New characteristic of quantum many-body chaotic systems. Physical Review. E. 99: 010102. PMID 30780329 DOI: 10.1103/PhysRevE.99.010102  0.64
2019 Jiang L, Sun C, Calzavarini E. Robustness of heat transfer in confined inclined convection at high Prandtl number. Physical Review. E. 99: 013108. PMID 30780316 DOI: 10.1103/PhysRevE.99.013108  0.64
2019 Liao S, Zhang W, Chen H, Zou L, Liu J, Zheng X. Atwood number effects on the instability of a uniform interface driven by a perturbed shock wave. Physical Review. E. 99: 013103. PMID 30780310 DOI: 10.1103/PhysRevE.99.013103  0.4
2019 Cai LB, Chaté H, Ma YQ, Shi XQ. Dynamical subclasses of dry active nematics. Physical Review. E. 99: 010601. PMID 30780307 DOI: 10.1103/PhysRevE.99.010601  0.48
2019 Mehdizadeh-Rad H, Singh J. Influence of Urbach energy, temperature, and longitudinal position in the active layer on carrier diffusion length in perovskite solar cells. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 30672099 DOI: 10.1002/cphc.201801038  1
2019 Zeng Z, Xia L, Fan X, Ostriker AC, Yarovinsky T, Su M, Zhang Y, Peng X, Yi X, Pi L, Gu X, Chung SK, Martin KA, Liu R, Hwa J, et al. Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair. The Journal of Clinical Investigation. PMID 30645204 DOI: 10.1172/JCI124508  0.36
2019 Yang A, Fan H, Zhao Y, Chen X, Zhu Z, Zha X, Zhao Y, Chai X, Li J, Tu P, Hu Z. An immune-stimulating proteoglycan from the medicinal mushroom Huaier up-regulates NF-κB and MAPK signaling via Toll-like receptor 4. The Journal of Biological Chemistry. PMID 30602571 DOI: 10.1074/jbc.RA118.005477  0.32
2019 Kim SB, Nam YJ, Kim KH, Kim TN. Is endoscopic sphincterotomy beneficial for the treatment of acute gallstone pancreatitis with small bile duct stone? European Journal of Gastroenterology & Hepatology. 31: 192-196. PMID 30576296 DOI: 10.1097/MEG.0000000000001329  0.4
2018 Gurevic I, Islam Z, Świderek K, Trepka K, Ghosh AK, Moliner V, Kohen A. Experimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer for E. coli Thymidylate Synthase. Acs Catalysis. 8: 10241-10253. PMID 31275729 DOI: 10.1021/acscatal.8b02554  0.52
2018 Chen Y, Chen W, Lan Y, Wang K, Wu Y, Zhong X, Ying K, Li J, Yang G. Determination of 18 phenolic acids in tobacco and rhizosphere soil by ultra-performance liquid chromatography combined with triple quadrupole mass spectrometry. Journal of Separation Science. PMID 30580494 DOI: 10.1002/jssc.201800819  0.6
2018 Wang Y, Gao P, Liang G, Zhang N, Wang C, Wang Y, Nie L, Lv X, Li W, Guo Q, Jiang X, Lu J. Maternal prenatal exposure to environmental factors and risk of childhood acute lymphocytic leukemia: A hospital-based case-control study in China. Cancer Epidemiology. 58: 146-152. PMID 30579239 DOI: 10.1016/j.canep.2018.11.005  0.36
2018 Holmqvist AS, Chen Y, Wu J, Battles K, Francisco L, Hageman L, Kung M, Ness E, Parman M, Winther JF, Rosenthal J, Arora M, Armenian SH, Bhatia S. Late Mortality after Allogeneic BMT in Childhood for Bone Marrow Failure Syndromes and Severe Aplastic Anemia. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. PMID 30578940 DOI: 10.1016/j.bbmt.2018.12.063  0.4
2018 Chi Z, Liu NN, Jiang H, Wang QQ, Chen JT, Liu GL, Hu Z, Chi ZM. Relationship between β-d-fructofuranosidase activity, fructooligosaccharides and pullulan biosynthesis in Aureobasidium melanogenum P16. International Journal of Biological Macromolecules. PMID 30578899 DOI: 10.1016/j.ijbiomac.2018.12.141  0.52
2018 Hu B, Wang H, He L, Li Y, Li C, Zhang Z, Liu Y, Zhou K, Zhang Q, Liu A, Liu S, Zhu Y, Luo Q. A method for extracting oil from cherry seed by ultrasonic-microwave assisted aqueous enzymatic process and evaluation of its quality. Journal of Chromatography. A. PMID 30578025 DOI: 10.1016/j.chroma.2018.12.027  0.56
2018 Wang P, Cui Y, Cai C, Chen H, Dai Y, Chen P, Kong F, Yuan J, Song X, Mei W, Dai H. Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus sp. HNWSW-1. Marine Drugs. 17. PMID 30577517 DOI: 10.3390/md17010004  0.48
2018 Liang M, Li X, Ouyang X, Xie H, Chen D. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules (Basel, Switzerland). 24. PMID 30577443 DOI: 10.3390/molecules24010003  0.44
2018 Deng R, Liao Y, Li Y, Tang J. Association of CYP3A5, CYP2C8, and ABCB1 Polymorphisms With Early Renal Injury in Chinese Liver Transplant Recipients Receiving Tacrolimus. Transplantation Proceedings. 50: 3258-3265. PMID 30577195 DOI: 10.1016/j.transproceed.2018.06.040  0.48
2018 Vo HNP, Ngo HH, Guo W, Liu Y, Chang SW, Nguyen DD, Nguyen PD, Bui XT, Ren J. Identification of the pollutants' removal and mechanism by microalgae in saline wastewater. Bioresource Technology. 275: 44-52. PMID 30576913 DOI: 10.1016/j.biortech.2018.12.026  0.48
2018 Xu S, Wusiman A, Liu Z, Gu P, Ni H, Zhang Y, Hu Y, Liu J, Wu Y, Wang D. pH-responsive Astragalus polysaccharides-loaded poly(lactic-co-glycolic acid) nanoparticles and their in vitro immunogenicity. International Journal of Biological Macromolecules. PMID 30576729 DOI: 10.1016/j.ijbiomac.2018.12.156  0.4
2018 Zheng H, Yu WL, Guo X, Zhao YZ, Cui Y, Hu T, Zhong JY. An effective immobilized haloalkane dehalogenase DhaA from Rhodococcus rhodochrous by adsorption, crosslink and PEGylation on meso-cellular foam. International Journal of Biological Macromolecules. PMID 30576728 DOI: 10.1016/j.ijbiomac.2018.12.127  0.4
2018 Li D, Zhao XM, Zhao HX, Long LS, Zheng LS. Coexistence of Magnetic-Optic-Electric Triple Switching and Thermal Energy Storage in a Multifunctional Plastic Crystal of Trimethylchloromethyl Ammonium Tetrachloroferrate(III). Inorganic Chemistry. PMID 30576116 DOI: 10.1021/acs.inorgchem.8b02835  0.32
2018 Liu X, Ji C, Wu Z, Li L, Wang Y, Han S, Sun Z, Luo J. [C5H12N]SnCl3: A Sn-halide Organic-inorganic Hybrid as Above-room-temperature Solid-state Nonlinear Optical Switch. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30575164 DOI: 10.1002/chem.201805390  0.4
2018 Zhang F, Xi S, Lin G, Hu X, Lou XWD, Xie K. Metallic Porous Iron Nitride and Tantalum Nitride Single Crystals with Enhanced Electrocatalysis Performance. Advanced Materials (Deerfield Beach, Fla.). e1806552. PMID 30575143 DOI: 10.1002/adma.201806552  0.4
2018 Wang Y, Kong W, Wang L, Zhang JZ, Li Y, Liu X, Li Y. Optimizing oxygen functional groups in graphene quantum dots for improved antioxidant mechanism. Physical Chemistry Chemical Physics : Pccp. PMID 30574959 DOI: 10.1039/c8cp06768f  0.68
2018 Huang W, Li N, Xu R, Li T, Li C. [Determination of nine pyrethroid pesticide residues in tea by gas chromatography-tandem mass spectrometry combined with accelerated solvent extraction and solid phase extraction]. SE Pu = Chinese Journal of Chromatography. 36: 1303-1310. PMID 30574710 DOI: 10.3724/SP.J.1123.2018.09019  0.44
2018 Li L, Zhao D, Liu Z, Zhang D, Hu Z, Li K, Yang J. Crystal structure of the lead-containing organic-inorganic hybrid: (CHN)[PbI(DMSO)]·2DMSO. Acta Crystallographica. Section E, Crystallographic Communications. 74: 1878-1880. PMID 30574392 DOI: 10.1107/S2056989018016584  0.44
2018 Yan Y, Zhou XE, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K. Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. The Journal of Biological Chemistry. PMID 30478170 DOI: 10.1074/jbc.RA118.004883  0.36
2018 Yun JH, Li X, Park JH, Wang Y, Ohki M, Jin Z, Lee W, Park SY, Hu H, Li C, Zatsepin N, Hunter MS, Sierra RG, Koralek J, Yoon CH, et al. Non-cryogenic structure of a chloride pump provides crucial clues to temperature-dependent channel transport efficiency. The Journal of Biological Chemistry. PMID 30455349 DOI: 10.1074/jbc.RA118.004038  0.32
2018 Mhashal AR, Pshetitsky Y, Cheatum CM, Kohen A, Major DT. Evolutionary Effects on Bound Substrate pKa in Dihydrofolate Reductase. Journal of the American Chemical Society. PMID 30398861 DOI: 10.1021/jacs.8b09089  1
2018 Kholodar SA, Ghosh AK, Świderek K, Moliner V, Kohen A. Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools. Proceedings of the National Academy of Sciences of the United States of America. PMID 30249644 DOI: 10.1073/pnas.1811059115  1
2018 Mhashal AR, Pshetitsky Y, Eitan R, Cheatum CM, Kohen A, Major DT. Effect of Asp122 Mutation on the Hydride Transfer in E. Coli DHFR Demonstrates the Goldilocks of Enzyme Flexibility. The Journal of Physical Chemistry. B. PMID 30040418 DOI: 10.1021/acs.jpcb.8b05556  1
2018 Yu D, Ding X, Liu Z, Wu X, Zhu Y, Wei H, Chong H, Cui S, He Y. Molecular mechanism of HIV-1 resistance to sifuvirtide, a clinical trial-approved membrane fusion inhibitor. The Journal of Biological Chemistry. PMID 29929981 DOI: 10.1074/jbc.RA118.003538  0.32
2018 Jin T, Brefo-Mensah E, Fan W, Zeng W, Li Y, Zhang Y, Palmer M. Crystal structure of the CAMP factor, and insights into its membrane-permeabilizing activity. The Journal of Biological Chemistry. PMID 29884770 DOI: 10.1074/jbc.RA118.002336  0.72
2018 Islam Z, Gurevic I, Strutzenberg TS, Ghosh AK, Iqbal T, Kohen A. Bacterial versus human thymidylate synthase: Kinetics and functionality. Plos One. 13: e0196506. PMID 29715278 DOI: 10.1371/journal.pone.0196506  0.52
2018 Mondal D, Koehn EM, Yao J, Wiemer DF, Kohen A. Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate. Bioorganic & Medicinal Chemistry. PMID 29606487 DOI: 10.1016/j.bmc.2018.03.032  1
2017 Ranasinghe C, Guo Q, Sapienza PJ, Lee AL, Quinn DM, Cheatum CM, Kohen A. Protein Mass Effects on Formate Dehydrogenase. Journal of the American Chemical Society. PMID 29083897 DOI: 10.1021/jacs.7b08359  1
2017 Kholodar SA, Ghosh AK, Kohen A. Measurement of Enzyme Isotope Effects. Methods in Enzymology. 596: 43-83. PMID 28911779 DOI: 10.1016/bs.mie.2017.06.033  1
2017 Karunaratne K, Luedtke N, Quinn DM, Kohen A. Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier. Archives of Biochemistry and Biophysics. PMID 28821425 DOI: 10.1016/j.abb.2017.08.011  1
2017 Mhashal AR, Vardi-Kilshtain A, Kohen A, Major DT. The Role of the M20 Loop in the Hydride Transfer in E. Coli Dihydrofolate Reductase. The Journal of Biological Chemistry. PMID 28620051 DOI: 10.1074/jbc.M117.777136  1
2017 Świderek K, Arafet K, Kohen A, Moliner V. Benchmarking Quantum Mechanics/Molecular Mechanics (QM/MM) Methods on the Thymidylate Synthase-Catalyzed Hydride Transfer. Journal of Chemical Theory and Computation. PMID 28192669 DOI: 10.1021/acs.jctc.6b01032  0.52
2016 Abeysinghe T, Hong B, Wang Z, Kohen A. Preserved hydride transfer mechanism in evolutionarily divergent thymidylate synthases. Current Topics in Biochemical Research. 17: 19-30. PMID 28018055  0.92
2016 Pshetitsky Y, Eitan R, Verner G, Kohen A, Major DT. Improved Sugar Puckering Profiles for Nicotinamide Ribonucleoside for Hybrid QM/MM Simulations. Journal of Chemical Theory and Computation. PMID 27490188 DOI: 10.1021/acs.jctc.6b00401  1
2016 Kholodar SA, Kohen A. Noncovalent Intermediate of Thymidylate Synthase: Fact or Fiction? Journal of the American Chemical Society. PMID 27327197 DOI: 10.1021/jacs.6b03826  1
2016 Pagano P, Guo Q, Kohen A, Cheatum CM. Oscillatory Enzyme Dynamics Revealed by Two-Dimensional Infrared Spectroscopy. The Journal of Physical Chemistry Letters. PMID 27305279 DOI: 10.1021/acs.jpclett.6b01154  1
2016 Guo Q, Gakhar L, Wickersham K, Francis K, Vardi-Kilshtain A, Major DT, Cheatum CM, Kohen A. Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii. Biochemistry. PMID 27100912 DOI: 10.1021/acs.biochem.6b00181  1
2016 Mishanina TV, Yu L, Karunaratne K, Mondal D, Corcoran JM, Choi MA, Kohen A. An unprecedented mechanism of nucleotide methylation in organisms containing thyX. Science (New York, N.Y.). 351: 507-10. PMID 26823429 DOI: 10.1126/science.aad0300  0.56
2016 Francis K, Sapienza PJ, Lee AL, Kohen A. The Effect of the Protein Mass Modulation on Human Dihydrofolate Reductase. Biochemistry. PMID 26813442 DOI: 10.1021/acs.biochem.5b00945  1
2015 Singh P, Francis K, Kohen A. Network of remote and local protein dynamics in dihydrofolate reductase catalysis. Acs Catalysis. 5: 3067-3073. PMID 27182453 DOI: 10.1021/acscatal.5b00331  1
2015 Kohen A. Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis. F1000research. 4. PMID 26918149 DOI: 10.12688/f1000research.6968.1  1
2015 Islam Z, Strutzenberg TS, Ghosh AK, Kohen A. Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction. Acs Catalysis. 5: 6061-6068. PMID 26576323 DOI: 10.1021/acscatal.5b01332  1
2015 Singh P, Morris H, Tivanski AV, Kohen A. A calibration curve for immobilized dihydrofolate reductase activity assay. Data in Brief. 4: 19-21. PMID 26217755 DOI: 10.1016/j.dib.2015.04.005  0.52
2015 Mishanina TV, Kohen A. Synthesis and application of isotopically labeled flavin nucleotides. Journal of Labelled Compounds & Radiopharmaceuticals. 58: 370-5. PMID 26149960 DOI: 10.1002/jlcr.3313  0.56
2015 Guo Q, Pagano P, Li YL, Kohen A, Cheatum CM. Line shape analysis of two-dimensional infrared spectra. The Journal of Chemical Physics. 142: 212427. PMID 26049447 DOI: 10.1063/1.4918350  1
2015 Ghosh AK, Islam Z, Krueger J, Abeysinghe T, Kohen A. The general base in the thymidylate synthase catalyzed proton abstraction. Physical Chemistry Chemical Physics : Pccp. PMID 25912171 DOI: 10.1039/c5cp01246e  1
2015 Swiderek K, Kohen A, Moliner V. The influence of active site conformations on the hydride transfer step of the thymidylate synthase reaction mechanism. Physical Chemistry Chemical Physics : Pccp. PMID 25868526 DOI: 10.1039/c5cp01239b  1
2015 Abeysinghe T, Kohen A. Role of long-range protein dynamics in different thymidylate synthase catalyzed reactions. International Journal of Molecular Sciences. 16: 7304-19. PMID 25837629 DOI: 10.3390/ijms16047304  0.64
2015 Singh P, Morris H, Tivanski AV, Kohen A. Determination of concentration and activity of immobilized enzymes. Analytical Biochemistry. 484: 169-72. PMID 25707319 DOI: 10.1016/j.ab.2015.02.014  0.52
2015 Singh P, Abeysinghe T, Kohen A. Linking protein motion to enzyme catalysis. Molecules (Basel, Switzerland). 20: 1192-209. PMID 25591120 DOI: 10.3390/molecules20011192  0.64
2015 Doron D, Stojkovi? V, Gakhar L, Vardi-Kilshtain A, Kohen A, Major DT. Free energy simulations of active-site mutants of dihydrofolate reductase. The Journal of Physical Chemistry. B. 119: 906-16. PMID 25382260 DOI: 10.1021/jp5059963  1
2015 Singh P, Abeysinghe T, Kohen A. Linking protein motion to enzyme catalysis Molecules. 20: 1192-1209. DOI: 10.3390/molecules20011192  1
2015 Abeysinghe T, Kohen A. Role of long-range protein dynamics in different thymidylate synthase catalyzed reactions International Journal of Molecular Sciences. 16: 7304-7319. DOI: 10.3390/ijms16047304  1
2015 Nilaweera TD, Saeed M, Kohen A. Targeting the de novo biosynthesis of thymidylate for the development of a pet probe for pancreatic cancer imaging Biochemistry. 54: 1287-1293. DOI: 10.1021/bi501481n  1
2015 Kohen A. Role of dynamics in enzyme catalysis: Substantial versus semantic controversies Accounts of Chemical Research. 48: 466-473. DOI: 10.1021/ar500322s  1
2015 Singh P, Francis K, Kohen A. Network of remote and local protein dynamics in dihydrofolate reductase catalysis Acs Catalysis. 5: 3067-3073. DOI: 10.1021/acscatal.5b00331  1
2015 Singh P, Morris H, Tivanski AV, Kohen A. A calibration curve for immobilized dihydrofolate reductase activity assay Data in Brief. 4: 19-21. DOI: 10.1016/j.dib.2015.04.005  1
2015 Singh P, Morris H, Tivanski AV, Kohen A. Determination of concentration and activity of immobilized enzymes Analytical Biochemistry. 484: 169-172. DOI: 10.1016/j.ab.2015.02.014  1
2015 Mishanina TV, Kohen A. Synthesis and application of isotopically labeled flavin nucleotides Journal of Labelled Compounds and Radiopharmaceuticals. DOI: 10.1002/jlcr.3313  1
2014 Liu CT, Francis K, Layfield JP, Huang X, Hammes-Schiffer S, Kohen A, Benkovic SJ. Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100. Proceedings of the National Academy of Sciences of the United States of America. 111: 18231-6. PMID 25453098 DOI: 10.1073/pnas.1415940111  1
2014 Klinman JP, Kohen A. Evolutionary aspects of enzyme dynamics. The Journal of Biological Chemistry. 289: 30205-12. PMID 25210031 DOI: 10.1074/jbc.R114.565515  1
2014 Mishanina TV, Corcoran JM, Kohen A. Substrate activation in flavin-dependent thymidylate synthase. Journal of the American Chemical Society. 136: 10597-600. PMID 25025487 DOI: 10.1021/ja506108b  0.56
2014 Doron D, Kohen A, Nam K, Major DT. How Accurate Are Transition States from Simulations of Enzymatic Reactions? Journal of Chemical Theory and Computation. 10: 1863-1871. PMID 24860275 DOI: 10.1021/ct5000742  1
2014 Wang Z, Singh P, Czekster CM, Kohen A, Schramm VL. Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations. Journal of the American Chemical Society. 136: 8333-41. PMID 24820793 DOI: 10.1021/ja501936d  1
2014 Roston D, Kohen A, Doron D, Major DT. Simulations of remote mutants of dihydrofolate reductase reveal the nature of a network of residues coupled to hydride transfer. Journal of Computational Chemistry. 35: 1411-7. PMID 24798860 DOI: 10.1002/jcc.23629  1
2014 Francis K, Kohen A. Protein motions and the activation of the CH bond catalyzed by dihydrofolate reductase. Current Opinion in Chemical Biology. 21: 19-24. PMID 24742825 DOI: 10.1016/j.cbpa.2014.03.009  1
2014 Singh P, Sen A, Francis K, Kohen A. Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase Journal of the American Chemical Society. 136: 2575-2582. PMID 24450297 DOI: 10.1021/ja411998h  1
2014 Roston D, Kohen A. Stereospecific multiple isotopic labeling of benzyl alcohol Journal of Labelled Compounds and Radiopharmaceuticals. 57: 75-77. PMID 24327376 DOI: 10.1002/jlcr.3143  1
2014 Roston D, Islam Z, Kohen A. Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactors Archives of Biochemistry and Biophysics. 544: 96-104. PMID 24161942 DOI: 10.1016/j.abb.2013.10.010  1
2014 Klinman JP, Kohen A. Evolutionary aspects of enzyme dynamics Journal of Biological Chemistry. 289: 30205-30212. DOI: 10.1074/jbc.R114.565515  1
2014 Mishanina TV, Corcoran JM, Kohen A. Substrate activation in flavin-dependent thymidylate synthase Journal of the American Chemical Society. 136: 10597-10600. DOI: 10.1021/ja506108b  1
2014 Islam Z, Strutzenberg TS, Gurevic I, Kohen A. Concerted versus stepwise mechanism in thymidylate synthase Journal of the American Chemical Society. 136: 9850-9853. DOI: 10.1021/ja504341g  1
2013 Francis K, Stojković V, Kohen A. Preservation of protein dynamics in dihydrofolate reductase evolution Journal of Biological Chemistry. 288: 35961-35968. PMID 24158440 DOI: 10.1074/jbc.M113.507632  1
2013 Roston D, Kohen A. A critical test of the "tunneling and coupled motion" concept in enzymatic alcohol oxidation Journal of the American Chemical Society. 135: 13624-13627. PMID 24020836 DOI: 10.1021/ja405917m  1
2013 Klinman JP, Kohen A. Hydrogen tunneling links protein dynamics to enzyme catalysis Annual Review of Biochemistry. 82: 471-496. PMID 23746260 DOI: 10.1146/annurev-biochem-051710-133623  1
2013 Roston D, Islam Z, Kohen A. Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions Molecules. 18: 5543-5567. PMID 23673528 DOI: 10.3390/molecules18055543  1
2013 Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. Journal of the American Chemical Society. 135: 7583-92. PMID 23611499 DOI: 10.1021/ja400761x  1
2013 Cheatum CM, Kohen A. Relationship of femtosecond-picosecond dynamics to enzyme-catalyzed H-transfer Topics in Current Chemistry. 337: 1-39. PMID 23539379 DOI: 10.1007/128_2012_407  1
2013 Wang Z, Ferrer S, Moliner V, Kohen A. QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase. Biochemistry. 52: 2348-58. PMID 23464672 DOI: 10.1021/bi400267q  1
2012 Vardi-Kilshtain A, Major DT, Kohen A, Engel H, Doron D. Hybrid Quantum and Classical Simulations of the Formate Dehydrogenase Catalyzed Hydride Transfer Reaction on an Accurate Semiempirical Potential Energy Surface. Journal of Chemical Theory and Computation. 8: 4786-4796. PMID 26605631 DOI: 10.1021/ct300628e  1
2012 Engel H, Doron D, Kohen A, Major DT. Momentum Distribution as a Fingerprint of Quantum Delocalization in Enzymatic Reactions: Open-Chain Path-Integral Simulations of Model Systems and the Hydride Transfer in Dihydrofolate Reductase. Journal of Chemical Theory and Computation. 8: 1223-34. PMID 26596739 DOI: 10.1021/ct200874q  1
2012 Doron D, Kohen A, Major DT. Collective Reaction Coordinate for Hybrid Quantum and Molecular Mechanics Simulations: A Case Study of the Hydride Transfer in Dihydrofolate Reductase. Journal of Chemical Theory and Computation. 8: 2484-96. PMID 26588977 DOI: 10.1021/ct300235k  1
2012 Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A. A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. Journal of the American Chemical Society. 134: 17722-30. PMID 23034004 DOI: 10.1021/ja307859m  1
2012 Koehn EM, Perissinotti LL, Moghram S, Prabhakar A, Lesley SA, Mathews II, Kohen A. Folate binding site of flavin-dependent thymidylate synthase Proceedings of the National Academy of Sciences of the United States of America. 109: 15722-15727. PMID 23019356 DOI: 10.1073/pnas.1206077109  1
2012 Sen A, Stojković V, Kohen A. Synthesis of radiolabeled nicotinamide cofactors from labeled pyridines: Versatile probes for enzyme kinetics Analytical Biochemistry. 430: 123-129. PMID 22922383 DOI: 10.1016/j.ab.2012.08.012  1
2012 Roston D, Cheatum CM, Kohen A. Hydrogen Donor-Acceptor fluctuations from kinetic isotope effects: A phenomenological model Biochemistry. 51: 6860-6870. PMID 22857146 DOI: 10.1021/bi300613e  1
2012 Liu Q, Zhao Y, Hammann B, Eilers J, Lu Y, Kohen A. A model reaction assesses contribution of H-tunneling and coupled motions to enzyme catalysis. The Journal of Organic Chemistry. 77: 6825-33. PMID 22834675 DOI: 10.1021/jo300879r  1
2012 Wang Z, Roston D, Kohen A. Experimental and theoretical studies of enzyme-catalyzed hydrogen-transfer reactions. Advances in Protein Chemistry and Structural Biology. 87: 155-80. PMID 22607755 DOI: 10.1016/B978-0-12-398312-1.00006-8  1
2012 Saeed M, Tewson TJ, Erdahl CE, Kohen A. A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells Nuclear Medicine and Biology. 39: 697-701. PMID 22300960 DOI: 10.1016/j.nucmedbio.2011.12.003  1
2012 Mishanina TV, Koehn EM, Conrad JA, Palfey BA, Lesley SA, Kohen A. Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase. Journal of the American Chemical Society. 134: 4442-8. PMID 22295882 DOI: 10.1021/ja2120822  1
2012 Mishanina TV, Koehn EM, Kohen A. Mechanisms and inhibition of uracil methylating enzymes Bioorganic Chemistry. 43: 37-43. PMID 22172597 DOI: 10.1016/j.bioorg.2011.11.005  1
2012 Stojkovi? V, Perissinotti LL, Willmer D, Benkovic SJ, Kohen A. Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction. Journal of the American Chemical Society. 134: 1738-45. PMID 22171795 DOI: 10.1021/ja209425w  1
2012 Dutta S, Li YL, Rock W, Houtman JC, Kohen A, Cheatum CM. 3-picolyl azide adenine dinucleotide as a probe of femtosecond to picosecond enzyme dynamics. The Journal of Physical Chemistry. B. 116: 542-8. PMID 22126535 DOI: 10.1021/jp208677u  1
2012 Dutta S, Li YL, Rock W, Houtman JCD, Kohen A, Cheatum CM. 3-picolyl azide adenine dinucleotide as a probe of femtosecond to picosecond enzyme dynamics Journal of Physical Chemistry B. 116: 542-548. DOI: 10.1021/jp208677u  1
2012 Vardi-Kilshtain A, Major DT, Kohen A, Engel H, Doron D. Hybrid quantum and classical simulations of the formate dehydrogenase catalyzed hydride transfer reaction on an accurate semiempirical potential energy surface Journal of Chemical Theory and Computation. 8: 4786-4796. DOI: 10.1021/ct300628e  1
2012 Doron D, Kohen A, Major DT. Collective reaction coordinate for hybrid quantum and molecular mechanics simulations: A case study of the hydride transfer in dihydrofolate reductase Journal of Chemical Theory and Computation. 8: 2484-2496. DOI: 10.1021/ct300235k  1
2012 Engel H, Doron D, Kohen A, Major DT. Momentum distribution as a fingerprint of quantum delocalization in enzymatic reactions: Open-chain path-integral simulations of model systems and the hydride transfer in dihydrofolate reductase Journal of Chemical Theory and Computation. 8: 1223-1234. DOI: 10.1021/ct200874q  1
2011 Doron D, Major DT, Kohen A, Thiel W, Wu X. Hybrid Quantum and Classical Simulations of the Dihydrofolate Reductase Catalyzed Hydride Transfer Reaction on an Accurate Semi-Empirical Potential Energy Surface. Journal of Chemical Theory and Computation. 7: 3420-37. PMID 26598171 DOI: 10.1021/ct2004808  1
2011 Oyeyemi OA, Sours KM, Lee T, Kohen A, Resing KA, Ahn NG, Klinman JP. Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °c: Identification of a single active site region with enhanced flexibility in the mesophilic protein Biochemistry. 50: 8251-8260. PMID 21859100 DOI: 10.1021/bi200640s  1
2011 Saeed M, Kohen A. Novel positron emission tomography tracer distinguishes normal from cancerous cells Journal of Biological Chemistry. 286: 33872-33878. PMID 21832075 DOI: 10.1074/jbc.M111.275446  1
2011 Dutta S, Rock W, Cook RJ, Kohen A, Cheatum CM. Two-dimensional infrared spectroscopy of azido-nicotinamide adenine dinucleotide in water. The Journal of Chemical Physics. 135: 055106. PMID 21823737 DOI: 10.1063/1.3623418  1
2011 Ditzler LR, Sen A, Gannon MJ, Kohen A, Tivanski AV. Self-assembled enzymatic monolayer directly bound to a gold surface: Activity and molecular recognition force spectroscopy studies Journal of the American Chemical Society. 133: 13284-13287. PMID 21809877 DOI: 10.1021/ja205409v  1
2011 Sen A, Yahashiri A, Kohen A. Triple isotopic labeling and kinetic isotope effects: Exposing H-transfer steps in enzymatic systems Biochemistry. 50: 6462-6468. PMID 21688781 DOI: 10.1021/bi2003873  1
2011 Kanaan N, Ferrer S, Martí S, Garcia-Viloca M, Kohen A, Moliner V. Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study. Journal of the American Chemical Society. 133: 6692-702. PMID 21476498 DOI: 10.1021/ja1114369  1
2011 Doron D, Major DT, Kohen A, Thiel W, Wu X. Hybrid quantum and classical simulations of the dihydrofolate reductase catalyzed hydride transfer reaction on an accurate semi-empirical potential energy surface Journal of Chemical Theory and Computation. 7: 3420-3437. DOI: 10.1021/ct2004808  1
2010 Stojkovi? V, Perissinotti LL, Lee J, Benkovic SJ, Kohen A. The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer. Chemical Communications (Cambridge, England). 46: 8974-6. PMID 20972508 DOI: 10.1039/c0cc02988b  1
2010 Bandaria JN, Dutta S, Nydegger MW, Rock W, Kohen A, Cheatum CM. Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase Proceedings of the National Academy of Sciences of the United States of America. 107: 17974-17979. PMID 20876138 DOI: 10.1073/pnas.0912190107  1
2010 Dutta S, Cook RJ, Houtman JCD, Kohen A, Cheatum CM. Characterization of azido-NAD+ to assess its potential as a two-dimensional infrared probe of enzyme dynamics Analytical Biochemistry. 407: 241-246. PMID 20705046 DOI: 10.1016/j.ab.2010.08.008  1
2010 Wang Z, Kohen A. Thymidylate synthase catalyzed H-transfers: two chapters in one tale. Journal of the American Chemical Society. 132: 9820-5. PMID 20575541 DOI: 10.1021/ja103010b  1
2010 Roston D, Kohen A. Elusive transition state of alcohol dehydrogenase unveiled Proceedings of the National Academy of Sciences of the United States of America. 107: 9572-9577. PMID 20457944 DOI: 10.1073/pnas.1000931107  1
2010 Koehn EM, Kohen A. Flavin-dependent thymidylate synthase: A novel pathway towards thymine Archives of Biochemistry and Biophysics. 493: 96-102. PMID 19643076 DOI: 10.1016/j.abb.2009.07.016  1
2010 Sen A, Kohen A. Enzymatic tunneling and kinetic isotope effects: Chemistry at the crossroads Journal of Physical Organic Chemistry. 23: 613-619. DOI: 10.1002/poc.1633  1
2009 Yahashiri A, Sen A, Kohen A. Microscale synthesis and kinetic isotope effect analysis of (4R)-[Ad-(14)C, 4-(2)H] NADPH and (4R)-[Ad-(3)H,4-(2)H] NADPH. Journal of Labelled Compounds & Radiopharmaceuticals. 52: 463-466. PMID 26045633 DOI: 10.1002/jlcr.1660  1
2009 Yahashiri A, Nimrod G, Ben-Tal N, Howell EE, Kohen A. The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase Chembiochem. 10: 2620-2623. PMID 19774544 DOI: 10.1002/cbic.200900451  1
2009 Hill SE, Bandaria JN, Fox M, Vanderah E, Kohen A, Cheatum CM. Exploring the molecular origins of protein dynamics in the active site of human carbonic anhydrase II. The Journal of Physical Chemistry. B. 113: 11505-10. PMID 19637848 DOI: 10.1021/jp901321m  1
2009 Bandaria JN, Cheatum CM, Kohen A. Examination of enzymatic H-tunneling through kinetics and dynamics Journal of the American Chemical Society. 131: 10151-10155. PMID 19621965 DOI: 10.1021/ja902120t  1
2009 Wang Z, Chernyshev A, Koehn EM, Manuel TD, Lesley SA, Kohen A. Oxidase activity of a flavin-dependent thymidylate synthase. The Febs Journal. 276: 2801-10. PMID 19459936 DOI: 10.1111/j.1742-4658.2009.07003.x  1
2009 Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A. An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene Nature. 458: 919-923. PMID 19370033 DOI: 10.1038/nature07973  1
2009 Kanaan N, Martí S, Moliner V, Kohen A. QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step. The Journal of Physical Chemistry. A. 113: 2176-82. PMID 19182971 DOI: 10.1021/jp810548d  1
2009 Stojković V, Kohen A. Minireview: Enzymatic H transfers: Quantum tunneling and coupled motion from kinetic isotope effect studies Israel Journal of Chemistry. 49: 163-173. DOI: 10.1560/IJC.49.2.163  1
2009 Hill SE, Bandaria JN, Fox M, Vanderah E, Kohen A, Cheatum CM. Exploring the molecular origins of protein dynamics in the active site of human carbonic anhydrase II Journal of Physical Chemistry B. 113: 11505-11510. DOI: 10.1021/jp901321m  1
2009 Yahashiri A, Sen A, Kohen A. Microscale synthesis and kinetic isotope effect analysis of (4R)-[Ad- 14C,4-2H] NADPH and (4R)-[Ad-3H,4- 2H] NADPH Journal of Labelled Compounds and Radiopharmaceuticals. 52: 463-466. DOI: 10.1002/jlcr.1660  1
2008 Yahashiri A, Howell EE, Kohen A. Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes Chemphyschem. 9: 980-982. PMID 18444258 DOI: 10.1002/cphc.200800067  1
2008 Bandaria JN, Dutta S, Hill SE, Kohen A, Cheatum CM. Fast enzyme dynamics at the active site of formate dehydrogenase Journal of the American Chemical Society. 130: 22-23. PMID 18067303 DOI: 10.1021/ja077599o  1
2007 Hong B, Maley F, Kohen A. Role of Y94 in proton and hydride transfers catalyzed by thymidylate synthase Biochemistry. 46: 14188-14197. PMID 17999469 DOI: 10.1021/bi701363s  1
2007 Chernyshev A, Fleischmann T, Koehn EM, Lesley SA, Kohen A. The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS) Chemical Communications. 2861-2863. PMID 17609801 DOI: 10.1039/b700977a  1
2007 Kanaan N, Martí S, Moliner V, Kohen A. A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase. Biochemistry. 46: 3704-13. PMID 17328531 DOI: 10.1021/bi061953y  1
2007 Chernyshev A, Fleischmann T, Kohen A. Thymidyl biosynthesis enzymes as antibiotic targets Applied Microbiology and Biotechnology. 74: 282-289. PMID 17216455 DOI: 10.1007/s00253-006-0763-1  1
2007 Kohen A. Current Issues in Enzymatic Hydrogen Transfer from Carbon: Tunneling and Coupled Motion from Kinetic Isotope Effect Studies Hydrogen-Transfer Reactions. 4: 1311-1340. DOI: 10.1002/9783527611546.ch41  1
2006 Wang L, Goodey NM, Benkovic SJ, Kohen A. Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 103: 15753-8. PMID 17032759 DOI: 10.1073/pnas.0606976103  1
2006 Limbach HH, Lopez JM, Kohen A. Arrhenius curves of hydrogen transfers: Tunnel effects, isotope effects and effects of pre-equilibria Philosophical Transactions of the Royal Society B: Biological Sciences. 361: 1399-1415. PMID 16873127 DOI: 10.1098/rstb.2006.1872  1
2006 Wang L, Goodey NM, Benkovic SJ, Kohen A. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 361: 1307-15. PMID 16873118 DOI: 10.1098/rstb.2006.1871  1
2006 Hong B, Haddad M, Maley F, Jensen JH, Kohen A. Hydride transfer versus hydrogen radical transfer in thymidylate synthase. Journal of the American Chemical Society. 128: 5636-7. PMID 16637621 DOI: 10.1021/ja060196o  1
2006 Mason A, Agrawal N, Washington MT, Lesley SA, Kohen A. A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link. Chemical Communications (Cambridge, England). 1781-3. PMID 16609803 DOI: 10.1039/b517881a  1
2006 Wang L, Tharp S, Selzer T, Benkovic SJ, Kohen A. Effects of a distal mutation on active site chemistry. Biochemistry. 45: 1383-92. PMID 16445280 DOI: 10.1021/bi0518242  1
2006 Markham KA, Kohen A. Analytical procedures for the preparation, isolation, analysis and preservation of reduced nicotinamides Current Analytical Chemistry. 2: 379-388. DOI: 10.2174/157341106778520508  1
2005 Pu J, Ma S, Garcia-Viloca M, Gao J, Truhlar DG, Kohen A. Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase. Journal of the American Chemical Society. 127: 14879-86. PMID 16231943 DOI: 10.1021/ja054170t  1
2005 Hong B, Kohen A. Microscale synthesis of isotopically labeled 6R-N5, N 10 methylene-5, 6, 7, 8-tetrahydrofolate Journal of Labelled Compounds and Radiopharmaceuticals. 48: 759-769. DOI: 10.1002/jlcr.993  1
2004 Sra AK, Hu Y, Martin GE, Snow DD, Ribbe MW, Kohen A. Competitive 15N kinetic isotope effects of nitrogenase-catalyzed dinitrogen reduction. Journal of the American Chemical Society. 126: 12768-9. PMID 15469259 DOI: 10.1021/ja0458470  1
2004 Agrawal N, Lesley SA, Kuhn P, Kohen A. Mechanistic studies of a flavin-dependent thymidylate synthase. Biochemistry. 43: 10295-301. PMID 15301527 DOI: 10.1021/bi0490439  1
2004 Agrawal N, Mihai C, Kohen A. Microscale synthesis of isotopically labeled R-[6-xH]N5,N10-methylene-5,6,7,8-tetrahydrofolate as a cofactor for thymidylate synthase. Analytical Biochemistry. 328: 44-50. PMID 15081906 DOI: 10.1016/j.ab.2004.01.029  1
2004 Sikorski RS, Wang L, Markham KA, Rajagopalan PT, Benkovic SJ, Kohen A. Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis. Journal of the American Chemical Society. 126: 4778-9. PMID 15080672 DOI: 10.1021/ja031683w  1
2004 Agrawal N, Hong B, Mihai C, Kohen A. Vibrationally enhanced hydrogen tunneling in the Escherichia coli thymidylate synthase catalyzed reaction. Biochemistry. 43: 1998-2006. PMID 14967040 DOI: 10.1021/bi036124g  1
2004 Markham KA, Sikorski RS, Kohen A. Synthesis and utility of 14C-labeled nicotinamide cofactors. Analytical Biochemistry. 325: 62-7. PMID 14715285 DOI: 10.1016/j.ab.2003.10.027  1
2004 McCracken JA, Wang L, Kohen A. Synthesis of R and S tritiated reduced beta-nicotinamide adenine dinucleotide 2' phosphate. Analytical Biochemistry. 324: 131-6. PMID 14654055 DOI: 10.1016/j.ab.2003.09.025  1
2003 Markham KA, Sikorski RS, Kohen A. Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate. Analytical Biochemistry. 322: 26-32. PMID 14705776 DOI: 10.1016/j.ab.2003.07.010  1
2003 Agrawal N, Kohen A. Microscale synthesis of 2-tritiated isopropanol and 4R-tritiated reduced nicotinamide adenine dinucleotide phosphate. Analytical Biochemistry. 322: 179-84. PMID 14596825 DOI: 10.1016/j.ab.2003.08.012  1
2003 Kohen A. Kinetic isotope effects as probes for hydrogen tunneling, coupled motion and dynamics contributions to enzyme catalysis Progress in Reaction Kinetics and Mechanism. 28: 119-156.  1
2002 Kohen A, Jensen JH. Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling. Journal of the American Chemical Society. 124: 3858-64. PMID 11942822 DOI: 10.1021/ja016909e  1
2001 Truhlar D, Kohen A. Convex Arrhenius plots and their interpretation. Proceedings of the National Academy of Sciences of the United States of America. 98: 848-51. PMID 11158559 DOI: 10.1073/pnas.98.3.848  1
2000 Kohen A, Klinman JP. Protein flexibility correlates with degree of hydrogen tunneling in thermophilic and mesophilic alcohol dehydrogenases [18] Journal of the American Chemical Society. 122: 10738-10739. DOI: 10.1021/ja002229k  1
1999 Kohen A, Klinman JP. Hydrogen tunneling in biology. Chemistry & Biology. 6: R191-8. PMID 10381408 DOI: 10.1016/S1074-5521(99)80058-1  1
1999 Kohen A, Cannio R, Bartolucci S, Klinman JP. Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase. Nature. 399: 496-9. PMID 10365965 DOI: 10.1038/20981  1
1998 Liang PH, Lewis J, Anderson KS, Kohen A, D'Souza FW, Benenson Y, Baasov T. Catalytic mechanism of Kdo8P synthase: transient kinetic studies and evaluation of a putative reaction intermediate. Biochemistry. 37: 16390-9. PMID 9819231 DOI: 10.1021/bi981374w  1
1998 Kohen A, Klinman JP. Enzyme Catalysis: Beyond Classical Paradigms Accounts of Chemical Research. 31: 397-404.  1
1997 Kohen A, Jonsson T, Klinman JP. Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction. Biochemistry. 36: 2603-11. PMID 9054567 DOI: 10.1021/bi962492r  1
1997 Kohen A, Jonsson T, Klinman JP. Effects of enzyme glycosylation on the chemical step of catalysis, as probed by hydrogen tunneling and enthalpy of activation Techniques in Protein Chemistry. 8: 311-319. DOI: 10.1016/S1080-8914(97)80032-4  1
1997 Liang PH, Kohen A, Baasov T, Anderson KS. Catalytic mechanism of Kdo8P synthase. Pre-steady-state kinetic analysis using rapid chemical quench flow methods Bioorganic and Medicinal Chemistry Letters. 7: 2463-2468. DOI: 10.1016/S0960-894X(97)10021-X  1
1997 Kohen A, Cannino R, Bartolucci S, Klimnan JP. Thermophilic dehydrogenase: Hydrogen tunneling at high and low temperature Faseb Journal. 11: A1133.  1
1995 Baasov T, Kohen A. Synthesis, inhibition, and acid-catalyzed hydrolysis studies of model compounds of the proposed intermediate in the Kdo8P-synthase-catalyzed reaction Journal of the American Chemical Society. 117: 6165-6172.  1
1994 Kohen A, Belakhov V, Baasov T. Towards the synthesis of the putative reaction intermediate in the Kdo8P synthase-catalyzed reaction. Synthesis and evaluation of 3-deoxy-d-manno-2-octulosonate-2-phosphate Tetrahedron Letters. 35: 3179-3182. DOI: 10.1016/S0040-4039(00)76861-4  1
1993 Baasov T, Sheffer-Dee-Noor S, Kohen A, Jakob A, Belakhov V. Catalytic mechanism of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase. The use of synthetic analogues to probe the structure of the putative reaction intermediate. European Journal of Biochemistry / Febs. 217: 991-9. PMID 8223657 DOI: 10.1111/j.1432-1033.1993.tb18330.x  1
1993 Kohen A, Berkovich R, Belakhov V, Baasov T. Stereochemistry of the KDO8P synthase. An efficient synthesis of the 3-fluoro analogues of KDO8P Bioorganic and Medicinal Chemistry Letters. 3: 1577-1582. DOI: 10.1016/S0960-894X(00)80021-9  1
1992 Kohen A, Jakob A, Baasov T. Mechanistic studies of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Escherichia coli. European Journal of Biochemistry / Febs. 208: 443-9. PMID 1521535  1
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