| Year |
Citation |
Score |
| 2000 |
Chang RL, Wood AW, Kumar S, Lehr RE, Shirai N, Jerina DM, Conney AH. Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice. Carcinogenesis. 21: 1997-2003. PMID 11062160 DOI: 10.1093/Carcin/21.11.1997 |
0.501 |
|
| 2000 |
Lewis RJ, Francis CA, Lehr RE, Blank CL. Synthesis and Neurotoxic Potential of Racemic and Chiral Dihydroxytetrahydroquinoline Derivatives Tetrahedron. 56: 5345-5352. DOI: 10.1016/S0040-4020(00)00470-1 |
0.307 |
|
| 1999 |
Adams JD, Sayer JM, Chadha A, Shirai N, Lehr RE, Kumar S, Jerina DM. The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats. Chemico-Biological Interactions. 122: 117-35. PMID 10528997 DOI: 10.1016/S0009-2797(99)00116-7 |
0.503 |
|
| 1995 |
LAKSHMAN MK, LEHR RE. ChemInform Abstract: Synthesis of 1,2-Epoxy-1,2,3,4-tetrahydrobenzo(g)chrysene: The First Synthesis of a Fjord-Region Tetrahydroepoxide. Cheminform. 26: no-no. DOI: 10.1002/chin.199516137 |
0.591 |
|
| 1994 |
Lakshman MK, Chaturvedi S, Lehr RE. Improved high-yield synthesis of polycyclic aromatic hydrocarbon amino tribenzoates, nucleophilic components for synthesis of diol epoxide-nucleoside adducts Synthetic Communications. 24: 2983-2988. DOI: 10.1080/00397919408010618 |
0.642 |
|
| 1994 |
Lakshman MK, Lehr RE. Synthesis of 1,2-epoxy-1,2,3,4-tetrahydro-benzofe]chrysene: The first synthesis of a fjord-region tetrahydroepoxide Synthetic Communications. 24: 2973-2981. DOI: 10.1080/00397919408010617 |
0.624 |
|
| 1992 |
Lakshman MK, Lehr RE. Solvent dependent changes in the proton nmr spectra of 2’ -deoxyadenosine and its derivatives Nucleosides and Nucleotides. 11: 1039-1046. DOI: 10.1080/07328319208021166 |
0.57 |
|
| 1990 |
Lakshman M, Nadkarni DV, Lehr RE. Regioselective ring opening of polycyclic aromatic hydrocarbon epoxides by polymer-supported azide anion Journal of Organic Chemistry. 55: 4892-4897. DOI: 10.1021/Jo00303A025 |
0.374 |
|
| 1990 |
Sayer JM, Lehr RE, Kumar S, Yagi H, Yeh HJC, Holder GM, Duke CC, Silverton JV, Gibson C, Jerina DM. Comparative solvolytic reactivity of bay-region diol epoxides derived from dibenz[a,j]anthracene and dibenzacridines Journal of the American Chemical Society. 112: 1177-1185. DOI: 10.1021/Ja00159A044 |
0.485 |
|
| 1990 |
Lakshman M, Lehr RE. Synthesis of polycyclic aromatic hydrocarbon 2′-deoxyadenosine analogs Tetrahedron Letters. 31: 1547-1550. DOI: 10.1016/0040-4039(90)80012-B |
0.398 |
|
| 1990 |
LAKSHMAN M, LEHR RE. ChemInform Abstract: Synthesis of Polycyclic Aromatic Hydrocarbon-Substituted 2′-Deoxyadenosine Analogs. Cheminform. 21. DOI: 10.1002/chin.199049299 |
0.621 |
|
| 1990 |
SAYER JM, LEHR RE, KUMAR S, YAGI H, YEH HJC, HOLDER GM, DUKE CC, SILVERTON JV, GIBSON C, JERINA DM. ChemInform Abstract: Comparative Solvolytic Reactivity of Bay-Region Diol Epoxides Derived from Dibenz(a,j)anthracene and Dibenzacridines Cheminform. 21. DOI: 10.1002/CHIN.199019080 |
0.51 |
|
| 1990 |
BUSHMAN DR, GROSSMAN SJ, JERINA DM, LEHR RE. ChemInform Abstract: Synthesis of Optically Active Fjord-Region 11,12-Diol 13,14-Epoxides and the K-Region 9,10-Oxide of the Carcinogen Benzo(g)chrysene. Cheminform. 21. DOI: 10.1002/CHIN.199001154 |
0.472 |
|
| 1989 |
Bushman DR, Grossman SJ, Jerina DM, Lehr RE. Synthesis of optically active fjord-region 11,12-diol 13,14-epoxides and the K-region 9,10-oxide of the carcinogen benzo[g]chrysene The Journal of Organic Chemistry. 54: 3533-3544. DOI: 10.1021/Jo00276A009 |
0.528 |
|
| 1989 |
Lehr RE, Kole PL, Singh M, Tschappat KD. Synthesis of the angular ring tetrahydroepoxides of the carcinogens 7- and 12-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene Journal of Organic Chemistry. 54: 850-857. DOI: 10.1021/Jo00265A025 |
0.409 |
|
| 1987 |
Utermoehlen CM, Singh M, Lehr RE. Fjord region 3,4-diol 1,2-epoxides and other derivatives in the 1,2,3,4- and 5,6,7,8-benzo rings of the carcinogen benzo[g]chrysene Journal of Organic Chemistry. 52: 5574-5582. DOI: 10.1021/Jo00234A013 |
0.403 |
|
| 1986 |
Lehr RE, Kole PL, Tschappat KD. Acetoxylation at benzylic positions of tetrahydrobenzo rings with DDQ in acetic acid Tetrahedron Letters. 27: 1649-1652. DOI: 10.1016/S0040-4039(00)84338-5 |
0.387 |
|
| 1985 |
Lehr RE, Kumar S, Shirai N, Jerina DM. Synthesis of enantiomerically pure bay-region 3,4-diol 1,2-epoxide diastereomers and other derivatives of the potent carcinogen dibenz[c,h]acridine The Journal of Organic Chemistry. 50: 98-107. DOI: 10.1002/Chin.198522224 |
0.573 |
|
| 1985 |
LEHR RE, KUMAR S, SHIRAI N, JERINA DM. ChemInform Abstract: SYNTHESIS OF ENANTIOMERICALLY PURE BAY-REGION 3,4-DIOL 1,2-EPOXIDE DIASTEREOMERS AND OTHER DERIVATIVES OF THE POTENT CARCINOGEN DIBENZ(C,H)ACRIDINE Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198522224 |
0.535 |
|
| 1983 |
Lehr RE, Jerina DM. Aza-polycyclic aromatic hydrocarbon carcinogenicity: predictions of reactivity of tetrahydrobenzo ring epoxide derivatives Tetrahedron Letters. 24: 27-30. DOI: 10.1016/S0040-4039(00)81317-9 |
0.547 |
|
| 1983 |
LEHR RE, JERINA DM. ChemInform Abstract: AZA-POLYCYCLIC AROMATIC HYDROCARBON CARCINOGENICITY: PREDICTIONS OF REACTIVITY OF TETRAHYDROBENZO RING EPOXIDE DERIVATIVES Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198319039 |
0.504 |
|
| 1982 |
Wood AW, Huang MT, Chang RL, Newmark HL, Lehr RE, Yagi H, Sayer JM, Jerina DM, Conney AH. Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid. Proceedings of the National Academy of Sciences of the United States of America. 79: 5513-7. PMID 6752950 DOI: 10.1073/Pnas.79.18.5513 |
0.475 |
|
| 1982 |
Kumar S, Lehr RE. Tetrahydroepoxides and diol epoxides of benz[c]acridine Tetrahedron Letters. 23: 4523-4526. DOI: 10.1016/S0040-4039(00)85643-9 |
0.396 |
|
| 1982 |
Sayer JM, Lehr RE, Whalen DL, Yagi H, Jerina DM. Structure-reactivity indices for the hydrolysis of diol epoxides of polycyclic aromatic hydrocarbons Tetrahedron Letters. 23: 4431-4434. DOI: 10.1016/S0040-4039(00)85620-8 |
0.491 |
|
| 1981 |
Wood AW, Chang RL, Levin W, Ryan DE, Thomas PE, Lehr RE, Kumar S, Sardella DJ, Boger E, Yagi H, Sayer JM, Jerina DM, Conney AH. Mutagenicity of the bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene. Cancer Research. 41: 2589-97. PMID 7018665 |
0.307 |
|
| 1981 |
Lehr RE, Kumar S. Synthesis of dihydrodiol and other derivatives of benz[c]acridine Journal of Organic Chemistry. 13: 3675-3681. DOI: 10.1021/Jo00331A019 |
0.375 |
|
| 1980 |
MacLeod MC, Levin W, Conney AH, Lehr RE, Mansfield BK, Jerina DM, Selkirk JK. Metabolism of benzo(e)pyrene by rat liver microsomal enzymes. Carcinogenesis. 1: 165-73. PMID 22282997 DOI: 10.1093/Carcin/1.2.165 |
0.473 |
|
| 1980 |
Jerina DM, Yagi H, Thakker DR, Lehr RE, Wood AW, Levin W, Conney AH. Bay-Region Activation Of Polycyclic Aromatic Hydrocarbons To Ultimate Mutagens And Carcinogens Microsomes, Drug Oxidations and Chemical Carcinogenesis. 1041-1051. DOI: 10.1016/B978-0-12-187702-6.50088-8 |
0.331 |
|
| 1980 |
YAGI H, THAKKER DR, LEHR RE, JERINA DM. ChemInform Abstract: BENZO-RING DIOL EPOXIDES OF BENZO(E)PYRENE AND TRIPHENYLENE Chemischer Informationsdienst. 11. DOI: 10.1002/Chin.198003247 |
0.506 |
|
| 1980 |
LEHR RE, KUMAR S, COHENOUR PT, JERINA DM. ChemInform Abstract: DIHYDRODIOLS AND DIOL EPOXIDES OF DIBENZO(A,I)- AND -(A,H)PYRENE Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198002204 |
0.415 |
|
| 1979 |
Wislocki PG, Buening MK, Levin W, Lehr RE, Thakker DR, Jerina DM, Conney AH. Tumorigenicity of the diastereomeric benz[a]anthracene 3,4-diol-1,2-epoxides and the (+)- and (-)-enantiomers of benz[a]anthracene 3,4-dihydrodiol in newborn mice. Journal of the National Cancer Institute. 63: 201-4. PMID 286829 DOI: 10.1093/Jnci/63.1.201 |
0.477 |
|
| 1979 |
Yagi H, Thakker DR, Lehr RE, Jerina DM. Benzo-ring diol epoxides of benzo[e]pyrene and triphenylene Journal of Organic Chemistry. 44: 3439-3442. DOI: 10.1021/Jo01333A047 |
0.517 |
|
| 1979 |
Lehr RE, Kumar S, Cohenour PT, Jerina DM. Dihydrodiols and diol epoxides of dibenzo[a,i]-and [a,h]pyrene Tetrahedron Letters. 20: 3819-3822. DOI: 10.1016/S0040-4039(01)95533-9 |
0.517 |
|
| 1979 |
LEHR RE, TAYLOR CW, KUMAR S, MAH HD, JERINA DM. ChemInform Abstract: SYNTHESIS OF THE NON-K-REGION AND K-REGION TRANS-DIHYDRODIOLS OF BENZO(E)PYRENE Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197906145 |
0.463 |
|
| 1978 |
Lehr RE, Taylor CW, Kumar S, Mah HD, Jerina DM. Synthesis of the non-K-region and K-region trans-dihydrodiols of benzo[e]pyrene The Journal of Organic Chemistry. 43: 3462-3466. DOI: 10.1021/Jo00412A008 |
0.511 |
|
| 1977 |
Lehr RE, Jerina DM. Metabolic activations of polycyclic hydrocarbons - Structure-activity relationships Archives of Toxicology. 39: 1-6. PMID 579975 DOI: 10.1007/Bf00343269 |
0.526 |
|
| 1977 |
Wood AW, Chang RL, Levin W, Lehr RE, Schaefer-Ridder M, Karle JM, Jerina DM, Conney AH. Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxides Proceedings of the National Academy of Sciences of the United States of America. 74: 2746-2750. PMID 331315 DOI: 10.1073/Pnas.74.7.2746 |
0.556 |
|
| 1977 |
Lehr RE, Jerina DM. Relationships of quantum mechanical calculations, relative mutagenicity of benzom anthracene diol epoxides, and “Bay region” concept of aromatic hydrocarbon carcinogenicity Journal of Toxicology and Environmental Health. 2: 1259-1265. PMID 328916 DOI: 10.1080/15287397709529528 |
0.521 |
|
| 1977 |
Wood AW, Levin W, Chang RL, Lehr RE, Schaefer-Ridder M, Karle JM, Jerina DM, Conney AH. Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol. Proceedings of the National Academy of Sciences of the United States of America. 74: 3176-9. PMID 269381 DOI: 10.1073/Pnas.74.8.3176 |
0.458 |
|
| 1977 |
Lehr RE, Schaefer-Ridder M, Jerina DM. Synthesis and properties of the vicinal trans dihydrodiols of anthracene, phenanthrene, and benzo[a]anthracene The Journal of Organic Chemistry. 42: 736-744. DOI: 10.1021/Jo00424A036 |
0.543 |
|
| 1977 |
Lehr RE, Schaefer-Ridder M, Jerina DM. Synthesis and reactivity of diol epoxides derived from non-K-region trans-dihydrodiols of benzo[a]anthracene Tetrahedron Letters. 18: 539-542. DOI: 10.1016/S0040-4039(01)92688-7 |
0.519 |
|
| 1977 |
LEHR RE, SCHAEFER-RIDDER M, JERINA DM. ChemInform Abstract: SYNTHESIS AND REACTIVITY OF DIOL EPOXIDES DERIVED FROM NON-K-REGION TRANS-DIHYDRODIOLS OF BENZO(A)ANTHRACENE Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197724212 |
0.528 |
|
| 1976 |
Wood AW, Levin W, Lu AYH, Ryan D, West SB, Lehr RE, Schaefer-Ridder M, Jerina DM, Conney AH. Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: Evidence for bay region activation of carcinogenic polycyclic hydrocarbons Biochemical and Biophysical Research Communications. 72: 680-686. PMID 791280 DOI: 10.1016/S0006-291X(76)80093-9 |
0.45 |
|
| 1971 |
Wilson JM, Lehr RE. N,N′-Oxalyl-Di-Imidazolide - A New Reagent for the Synthesis of Symmetrical Organic Oxalates Synthetic Communications. 1: 253-256. DOI: 10.1080/00397917108082705 |
0.332 |
|
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