☰

Ben Hackel - Publications

Affiliations: 
2009-2011 Chemical Engineering and Materials Science University of Minnesota, Twin Cities, Minneapolis, MN 
Tree Info Similar researchers PubMed Report error

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Vunnam N, Szymonski S, Hirsova P, Gores G, Sachs JN, Hackel BJ. Noncompetitive allosteric antagonism of death receptor 5 by a synthetic affibody ligand. Biochemistry. PMID 32941010 DOI: 10.1021/Acs.Biochem.0C00529  0.577
2020 Tresnak DT, Hackel BJ. Mining and statistical modeling of natural and variant class IIa bacteriocins elucidates activity and selectivity profiles across species. Applied and Environmental Microbiology. PMID 32917749 DOI: 10.1128/AEM.01646-20  0.784
2020 Lown PS, Hackel BJ. Magnetic Bead-Immobilized Mammalian Cells Are Effective Targets to Enrich Ligand-Displaying Yeast. Acs Combinatorial Science. PMID 32283920 DOI: 10.1021/acscombsci.0c00036  0.815
2020 Kim M, Heinrich F, Haugstad G, Yu G, Yuan G, Satija SK, Zhang W, Seo HS, Metzger JM, Azarin SM, Lodge TP, Hackel BJ, Bates FS. Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 32216370 DOI: 10.1021/Acs.Langmuir.9B03208  0.535
2020 Bam R, Lown PS, Stern LA, Sharma K, Wilson KE, Bean GR, Lutz AM, Paulmurugan R, Hackel BJ, Dahl J, Abou-Elkacem L. Efficacy of affibody-based ultrasound molecular imaging of vascular B7-H3 for breast cancer detection. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31924738 DOI: 10.1158/1078-0432.Ccr-19-1655  0.767
2020 Stern LA, Lown PS, Hackel BJ. Ligand Engineering via Yeast Surface Display and Adherent Cell Panning. Methods in Molecular Biology (Clifton, N.J.). 2070: 303-320. PMID 31625103 DOI: 10.1007/978-1-4939-9853-1_17  0.808
2020 Vunnam N, Szymonski S, Petra H, Gores GJ, Hackel B, Sachs J. Noncompetitive allosteric antagonism of death receptor 5 by an affibody discovered via yeast display The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05692  0.533
2019 Baryakova TH, Ritter SC, Tresnak DT, Hackel BJ. Computationally-aided discovery of LysEFm5 variants with improved catalytic activity and stability. Applied and Environmental Microbiology. PMID 31811034 DOI: 10.1128/AEM.02051-19  0.788
2019 Klesmith JR, Wu L, Lobb RR, Rennert PD, Hackel BJ. Fine epitope mapping of the CD19 extracellular domain promotes design. Biochemistry. PMID 31702909 DOI: 10.1021/acs.biochem.9b00808  0.796
2019 Klesmith JR, Su L, Wu L, Schrack IA, Dufort FJ, Birt A, Ambrose C, Hackel BJ, Lobb RR, Rennert PD. Retargeting CD19 CAR T cells via engineered CD19-fusion proteins. Molecular Pharmaceutics. PMID 31242389 DOI: 10.1021/acs.molpharmaceut.9b00418  0.753
2019 Lai PK, Tresnak DT, Hackel BJ. Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery. Biotechnology and Bioengineering. PMID 31209863 DOI: 10.1002/bit.27092  0.774
2019 Bam R, Laffey M, Nottberg K, Lown PS, Hackel BJ, Wilson K. Affibody-indocyanine green based contrast agent for photoacoustic and fluorescence molecular imaging of B7-H3 expression in breast cancer. Bioconjugate Chemistry. PMID 31082216 DOI: 10.1021/Acs.Bioconjchem.9B00239  0.779
2019 Ritter SC, Hackel BJ. Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models. Applied and Environmental Microbiology. 85. PMID 30850429 DOI: 10.1128/AEM.00054-19  0.805
2019 Golinski AW, Holec PV, Mischler KM, Hackel BJ. Biophysical Characterization Platform Informs Protein Scaffold Evolvability. Acs Combinatorial Science. 21: 323-335. PMID 30681831 DOI: 10.1021/acscombsci.8b00182  0.8
2019 Stern LA, Lown P, Kobe AC, Abou-Elkacem L, Willmann JK, Hackel BJ. Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276. Acs Combinatorial Science. PMID 30620189 DOI: 10.1021/acscombsci.8b00156  0.805
2018 Case BA, Kruziki MA, Stern LA, Hackel BJ. Evaluation of affibody charge modification identified by synthetic consensus design in molecular PET imaging of epidermal growth factor receptor. Molecular Systems Design & Engineering. 3: 171-182. PMID 31467687 DOI: 10.1039/C7ME00095B  0.786
2018 Lai PK, Geldart K, Ritter S, Kaznessis YN, Hackel BJ. Systematic Mutagenesis of Oncocin Reveals Enhanced Activity and Insights into the Mechanisms of Antimicrobial Activity. Molecular Systems Design & Engineering. 3: 930-941. PMID 31105969 DOI: 10.1039/C8ME00051D  0.772
2018 Klesmith JR, Hackel BJ. Improved mutant function prediction via PACT: Protein Analysis and Classifier Toolkit. Bioinformatics (Oxford, England). PMID 30590444 DOI: 10.1093/bioinformatics/bty1042  0.775
2018 Du F, Kruziki MA, Zudock EJ, Zhang Y, Lown PS, Hackel BJ. Engineering an EGFR-Binding Gp2 Domain for Increased Hydrophilicity. Biotechnology and Bioengineering. PMID 30536855 DOI: 10.1002/bit.26893  0.805
2018 Csizmar CM, Petersburg J, Perry TJ, Rozumalski L, Hackel BJ, Wagner CR. Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density. Journal of the American Chemical Society. PMID 30507196 DOI: 10.1021/Jacs.8B09198  0.327
2018 Ritter SC, Yang ML, Kaznessis YN, Hackel BJ. Multi-species activity screening of microcin J25 mutants yields antimicrobials with increased specificity towards pathogenic Salmonella species relative to human commensal Escherichia coli. Biotechnology and Bioengineering. PMID 29940080 DOI: 10.1002/bit.26772  0.799
2018 Kruziki MA, Sarma V, Hackel BJ. Constrained combinatorial libraries of Gp2 proteins enhance discovery of PD-L1 binders. Acs Combinatorial Science. PMID 29799714 DOI: 10.1021/acscombsci.8b00010  0.795
2018 Kim M, Vala M, Ertsgaard C, Oh SH, Lodge TP, Bates FS, Hackel BJ. Surface plasmon resonance study of the binding of PEO-PPO-PEO triblock copolymer and PEO homopolymer to supported lipid bilayers. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 29787676 DOI: 10.1021/Acs.Langmuir.8B00873  0.552
2018 Case BA, Kruziki MA, Johnson SM, Hackel BJ. Engineered charge redistribution of Gp2 proteins through guided diversity for improved PET imaging of epidermal growth factor receptor. Bioconjugate Chemistry. PMID 29579383 DOI: 10.1021/acs.bioconjchem.8b00144  0.79
2018 Kim M, Haman K, Houang E, Zhang W, Yannopoulos D, Metzger J, Bates F, Hackel B. Myoblast Protection by Polyethylene Oxide-Polypropylene Oxide Block Copolymers against Hypo-Osmotic Stress Biophysical Journal. 114: 360a-361a. DOI: 10.1016/J.Bpj.2017.11.2003  0.486
2017 Houang EM, Haman KJ, Kim M, Zhang W, Lowe DA, Sham YY, Lodge TP, Hackel BJ, Bates FS, Metzger JM. Chemical endgroup modified diblock copolymers elucidate anchor and chain mechanism of membrane stabilization. Molecular Pharmaceutics. PMID 28538101 DOI: 10.1021/Acs.Molpharmaceut.7B00197  0.541
2017 Kim M, Haman KJ, Houang EM, Zhang W, Yannopoulos D, Metzger JM, Bates FS, Hackel BJ. PEO-PPO diblock copolymers protect myoblasts from hypo-osmotic stress in vitro dependent on copolymer size, composition, and architecture. Biomacromolecules. PMID 28535058 DOI: 10.1021/Acs.Biomac.7B00419  0.534
2017 Stern LA, Csizmar CM, Woldring DR, Wagner CR, Hackel BJ. Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands. Acs Combinatorial Science. PMID 28322543 DOI: 10.1021/Acscombsci.6B00191  0.79
2017 Woldring DR, Holec PV, Stern LA, Du Y, Hackel BJ. A gradient of sitewise diversity promotes evolutionary fitness for binder discovery in a three-helix bundle protein scaffold. Biochemistry. PMID 28248518 DOI: 10.1021/acs.biochem.6b01142  0.789
2017 Johnson SM, Javner C, Hackel BJ. Development and Implementation of a Protein–Protein Binding Experiment To Teach Intermolecular Interactions in High School or Undergraduate Classrooms Journal of Chemical Education. 94: 367-374. DOI: 10.1021/ACS.JCHEMED.6B00323  0.533
2017 Senkow TL, Woldring DR, Kruziki M, Hackel BJ, Sachs JN. Evaluation of High Affinity Scaffolds from High-Throughput Discovery and Targeting DR5 and TNFR1 Biophysical Journal. 112: 530a. DOI: 10.1016/J.Bpj.2016.11.2865  0.771
2016 Kruziki MA, Case BA, Chan JY, Zudock EJ, Woldring DR, Yee D, Hackel BJ. A 64Cu-labeled Gp2 Domain for PET Imaging of Epidermal Growth Factor Receptor. Molecular Pharmaceutics. PMID 27696863 DOI: 10.1021/Acs.Molpharmaceut.6B00538  0.755
2016 Abou-Elkacem L, Wilson KE, Johnson SM, Chowdhury SM, Bachawal S, Hackel BJ, Tian L, Willmann JK. Ultrasound Molecular Imaging of the Breast Cancer Neovasculature using Engineered Fibronectin Scaffold Ligands: A Novel Class of Targeted Contrast Ultrasound Agent. Theranostics. 6: 1740-52. PMID 27570547 DOI: 10.7150/thno.15169  0.622
2016 Stern LA, Schrack IA, Johnson SM, Deshpande A, Bennett NR, Harasymiw LA, Gardner MK, Hackel BJ. Geometry and expression enhance enrichment of functional yeast-displayed ligands via cell panning. Biotechnology and Bioengineering. PMID 27144954 DOI: 10.1002/bit.26001  0.801
2016 Woldring DR, Holec PV, Hackel BJ. ScaffoldSeq: Software for characterization of directed evolution populations. Proteins. 84: 869-74. PMID 27018773 DOI: 10.1002/prot.25040  0.748
2016 Case BA, Hackel BJ. Synthetic and natural consensus design for engineering charge within an affibody targeting epidermal growth factor receptor. Biotechnology and Bioengineering. PMID 26724421 DOI: 10.1002/bit.25931  0.805
2015 Woldring DR, Holec PV, Zhou H, Hackel BJ. High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains. Plos One. 10: e0138956. PMID 26383268 DOI: 10.1371/journal.pone.0138956  0.795
2015 McClintock MK, Kaznessis YN, Hackel BJ. Enterocin a mutants identified by saturation mutagenesis enhance potency towards vancomycin-resistant Enterococci. Biotechnology and Bioengineering. PMID 26191783 DOI: 10.1002/bit.25710  0.773
2015 Kruziki MA, Bhatnagar S, Woldring DR, Duong VT, Hackel BJ. A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering. Chemistry & Biology. 22: 946-56. PMID 26165154 DOI: 10.1016/j.chembiol.2015.06.012  0.816
2015 Morgounova E, Johnson SM, Shao Q, Hackel BJ, Wilson M, Ashkenazi S. In vitro characterization of a lifetime-based activatable photoacoustic probe Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9323. DOI: 10.1117/12.2080362  0.578
2014 Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Applied and Environmental Microbiology. 80: 5732-42. PMID 25015885 DOI: 10.1128/Aem.01466-14  0.58
2014 Morgounova E, Johnson SM, Shao Q, Hackel B, Ashkenazi S. Lifetime-based photoacoustic probe activation modeled by a dual methylene blue-lysine conjugate Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8943. DOI: 10.1117/12.2041006  0.537
2013 Stern LA, Case BA, Hackel BJ. Alternative Non-Antibody Protein Scaffolds for Molecular Imaging of Cancer. Current Opinion in Chemical Engineering. 2. PMID 24358455 DOI: 10.1016/j.coche.2013.08.009  0.806
2013 Natarajan A, Hackel BJ, Gambhir SS. A novel engineered anti-CD20 tracer enables early time PET imaging in a humanized transgenic mouse model of B-cell non-Hodgkins lymphoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 6820-9. PMID 24097872 DOI: 10.1158/1078-0432.Ccr-13-0626  0.402
2013 Hackel BJ, Kimura RH, Miao Z, Liu H, Sathirachinda A, Cheng Z, Chin FT, Gambhir SS. 18F-fluorobenzoate-labeled cystine knot peptides for PET imaging of integrin αvβ6. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 1101-5. PMID 23670900 DOI: 10.2967/Jnumed.112.110759  0.694
2013 Chen TF, de Picciotto S, Hackel BJ, Wittrup KD. Engineering fibronectin-based binding proteins by yeast surface display. Methods in Enzymology. 523: 303-26. PMID 23422436 DOI: 10.1016/B978-0-12-394292-0.00014-X  0.562
2013 Stern LA, Case BA, Hackel BJ. Alternative non-antibody protein scaffolds for molecular imaging of cancer Current Opinion in Chemical Engineering. 2: 425-432. DOI: 10.1016/j.coche.2013.08.009  0.806
2012 Hackel BJ, Sathirachinda A, Gambhir SS. Designed hydrophilic and charge mutations of the fibronectin domain: towards tailored protein biodistribution. Protein Engineering, Design & Selection : Peds. 25: 639-47. PMID 22691700 DOI: 10.1093/Protein/Gzs036  0.49
2012 Hackel BJ, Kimura RH, Gambhir SS. Use of (64)Cu-labeled fibronectin domain with EGFR-overexpressing tumor xenograft: molecular imaging. Radiology. 263: 179-88. PMID 22344401 DOI: 10.1148/Radiol.12111504  0.437
2012 Kimura RH, Teed R, Hackel BJ, Pysz MA, Chuang CZ, Sathirachinda A, Willmann JK, Gambhir SS. Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 839-49. PMID 22173551 DOI: 10.1158/1078-0432.Ccr-11-1116  0.378
2012 Hackel BJ, Neil JR, White FM, Wittrup KD. Epidermal growth factor receptor downregulation by small heterodimeric binding proteins. Protein Engineering, Design & Selection : Peds. 25: 47-57. PMID 22160867 DOI: 10.1093/Protein/Gzr056  0.575
2011 Pirie CM, Hackel BJ, Rosenblum MG, Wittrup KD. Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties. The Journal of Biological Chemistry. 286: 4165-72. PMID 21138845 DOI: 10.1074/Jbc.M110.186973  0.515
2011 Hackel BJ, Wittrup KD. Yeast Surface Display in Protein Engineering and Analysis Protein Engineering Handbook, Volume 1 & Volume 2. 2: 621-648. DOI: 10.1002/9783527634026.ch26  0.475
2010 Hackel BJ, Ackerman ME, Howland SW, Wittrup KD. Stability and CDR composition biases enrich binder functionality landscapes. Journal of Molecular Biology. 401: 84-96. PMID 20540948 DOI: 10.1016/J.Jmb.2010.06.004  0.547
2010 Hackel BJ, Wittrup KD. The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold. Protein Engineering, Design & Selection : Peds. 23: 211-9. PMID 20067921 DOI: 10.1093/Protein/Gzp083  0.572
2009 Ackerman M, Levary D, Tobon G, Hackel B, Orcutt KD, Wittrup KD. Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display. Biotechnology Progress. 25: 774-83. PMID 19363813 DOI: 10.1002/Btpr.174  0.564
2008 Hackel BJ, Kapila A, Wittrup KD. Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling. Journal of Molecular Biology. 381: 1238-52. PMID 18602401 DOI: 10.1016/J.Jmb.2008.06.051  0.562
2007 Lipovsek D, Lippow SM, Hackel BJ, Gregson MW, Cheng P, Kapila A, Wittrup KD. Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies. Journal of Molecular Biology. 368: 1024-41. PMID 17382960 DOI: 10.1016/J.Jmb.2007.02.029  0.565
2006 Chao G, Lau WL, Hackel BJ, Sazinsky SL, Lippow SM, Wittrup KD. Isolating and engineering human antibodies using yeast surface display. Nature Protocols. 1: 755-68. PMID 17406305 DOI: 10.1038/Nprot.2006.94  0.528
2006 Hackel BJ, Huang D, Bubolz JC, Wang XX, Shusta EV. Production of soluble and active transferrin receptor-targeting single-chain antibody using Saccharomyces cerevisiae. Pharmaceutical Research. 23: 790-7. PMID 16550469 DOI: 10.1007/S11095-006-9778-7  0.563
Show low-probability matches.