Richard J Youle, PhD - Publications

Biochemistry National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States 
Cell biology; Biochemistry

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Baldwin HA, Wang C, Kanfer G, Shah HV, Velayos-Baeza A, Dulovic-Mahlow M, Brüggemann N, Anding A, Baehrecke EH, Maric D, Prinz WA, Youle RJ. VPS13D promotes peroxisome biogenesis. The Journal of Cell Biology. 220. PMID 33891012 DOI: 10.1083/jcb.202001188  1
2021 Kanfer G, Sarraf SA, Maman Y, Baldwin H, Dominguez-Martin E, Johnson KR, Ward ME, Kampmann M, Lippincott-Schwartz J, Youle RJ. Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. The Journal of Cell Biology. 220. PMID 33464298 DOI: 10.1083/jcb.202006180  1
2020 Le Guerroué F, Youle RJ. Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective. Cell Death and Differentiation. PMID 33208890 DOI: 10.1038/s41418-020-00667-x  0.8
2020 Sarraf SA, Shah HV, Kanfer G, Pickrell AM, Holtzclaw LA, Ward ME, Youle RJ. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Molecular Cell. PMID 33207181 DOI: 10.1016/j.molcel.2020.10.041  1
2020 Fischer TD, Wang C, Padman BS, Lazarou M, Youle RJ. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain. The Journal of Cell Biology. 219. PMID 33201170 DOI: 10.1083/jcb.202009128  1
2020 Borsche M, König IR, Delcambre S, Petrucci S, Balck A, Brüggemann N, Zimprich A, Wasner K, Pereira SL, Avenali M, Deuschle C, Badanjak K, Ghelfi J, Gasser T, Kasten M, ... ... Youle RJ, et al. Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain : a Journal of Neurology. PMID 33029617 DOI: 10.1093/brain/awaa246  1
2020 Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH. ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer. The Journal of Cell Biology. 219. PMID 32516362 DOI: 10.1083/Jcb.201911047  1
2019 Sarraf SA, Sideris DP, Giagtzoglou N, Ni L, Kankel MW, Sen A, Bochicchio LE, Huang CH, Nussenzweig SC, Worley SH, Morton PD, Artavanis-Tsakonas S, Youle RJ, Pickrell AM. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Reports. 29: 225-235.e5. PMID 31577952 DOI: 10.1016/J.Celrep.2019.08.085  1
2019 Lomash RM, Petralia RS, Holtzclaw LA, Tsuda MC, Wang YX, Badger JD, Cameron HA, Youle RJ, Roche KW. Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo. The Journal of Biological Chemistry. PMID 31177092 DOI: 10.1074/Jbc.Ra118.007245  0.36
2019 Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy. Molecular Cell. PMID 30853401 DOI: 10.1016/J.Molcel.2019.02.010  1
2019 Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ. Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1. Molecular Cell. PMID 30733118 DOI: 10.1016/J.Molcel.2019.01.002  1
2019 Ader NR, Hoffmann PC, Ganeva I, Borgeaud AC, Wang C, Youle RJ, Kukulski W. Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis. Elife. 8. PMID 30714902 DOI: 10.7554/Elife.40712  1
2018 Samstag CL, Hoekstra JG, Huang CH, Chaisson MJ, Youle RJ, Kennedy SR, Pallanck LJ. Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ. Plos Genetics. 14: e1007805. PMID 30452458 DOI: 10.1371/Journal.Pgen.1007805  0.96
2018 Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-induced inflammation. Nature. PMID 30135585 DOI: 10.1038/S41586-018-0448-9  1
2018 Le Guerroué F, Youle RJ. Active state of Parkin. Nature Structural & Molecular Biology. PMID 30038392 DOI: 10.1038/S41594-018-0101-1  0.8
2018 Sarraf SA, Youle RJ. Parkin mediates mitophagy during beige-to-white fat conversion. Science Signaling. 11. PMID 29692360 DOI: 10.1126/Scisignal.Aat1082  0.36
2018 Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ. Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife. 7. PMID 29360040 DOI: 10.7554/Elife.31326  1
2018 Sekine S, Youle RJ. PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol. Bmc Biology. 16: 2. PMID 29325568 DOI: 10.1186/S12915-017-0470-7  1
2017 Anding AL, Wang C, Chang TK, Sliter DA, Powers CM, Hofmann K, Youle RJ, Baehrecke EH. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Current Biology : Cb. PMID 29307555 DOI: 10.1016/J.Cub.2017.11.064  1
2017 Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, Youle AM, Nezich CL, Wu X, Hammer JA, Youle RJ. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. The Journal of Cell Biology. PMID 28893839 DOI: 10.1083/Jcb.201612106  1
2016 Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. The Embo Journal. PMID 28028054 DOI: 10.15252/Embj.201695063  1
2016 Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035970 DOI: 10.1073/Pnas.1523926113  0.68
2016 Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Molecular Cell. 61: 654-66. PMID 26942670 DOI: 10.1016/J.Molcel.2016.01.028  0.68
2016 Yao Y, Nisan D, Antignani A, Barnes A, Tjandra N, Youle RJ, Marassi FM, Fujimoto LM. Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL. Protein Expression and Purification. 122: 56-63. PMID 26923059 DOI: 10.1016/J.Pep.2016.02.010  0.68
2015 Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 524: 309-14. PMID 26266977 DOI: 10.1038/Nature14893  0.68
2015 Nezich CL, Wang C, Fogel AI, Youle RJ. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. The Journal of Cell Biology. 210: 435-50. PMID 26240184 DOI: 10.1083/Jcb.201501002  1
2015 Lomash RM, Gu X, Youle RJ, Lu W, Roche KW. Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. Cell Reports. PMID 26212327 DOI: 10.1016/J.Celrep.2015.06.064  0.68
2015 Pickrell AM, Huang CH, Kennedy SR, Ordureau A, Sideris DP, Hoekstra JG, Harper JW, Youle RJ. Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron. 87: 371-81. PMID 26182419 DOI: 10.1016/J.Neuron.2015.06.034  0.68
2015 Hasson SA, Fogel AI, Wang C, MacArthur R, Guha R, Heman-Ackah S, Martin S, Youle RJ, Inglese J. Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. Acs Chemical Biology. 10: 1188-97. PMID 25689131 DOI: 10.1021/Cb5010417  0.68
2015 Pickrell AM, Youle RJ. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron. 85: 257-73. PMID 25611507 DOI: 10.1016/J.Neuron.2014.12.007  1
2014 Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. The Journal of Cell Biology. 205: 143-53. PMID 24751536 DOI: 10.1083/Jcb.201402104  0.68
2014 Randow F, Youle RJ. Self and nonself: how autophagy targets mitochondria and bacteria. Cell Host & Microbe. 15: 403-11. PMID 24721569 DOI: 10.1016/J.Chom.2014.03.012  1
2014 Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ. Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. Elife. 3: e01612. PMID 24569479 DOI: 10.7554/Elife.01612  0.68
2014 Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Molecular Biology of the Cell. 25: 145-59. PMID 24196833 DOI: 10.1091/Mbc.E13-09-0525  0.68
2013 Pickrell AM, Youle RJ. Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs. Current Biology : Cb. 23: R1052-4. PMID 24309284 DOI: 10.1016/J.Cub.2013.10.048  1
2013 Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature. 504: 291-5. PMID 24270810 DOI: 10.1038/Nature12748  0.68
2013 Jin SM, Youle RJ. The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria. Autophagy. 9: 1750-7. PMID 24149988 DOI: 10.4161/Auto.26122  0.64
2013 Stavru F, Palmer AE, Wang C, Youle RJ, Cossart P. Atypical mitochondrial fission upon bacterial infection. Proceedings of the National Academy of Sciences of the United States of America. 110: 16003-8. PMID 24043775 DOI: 10.1073/Pnas.1315784110  1
2013 Fogel AI, Dlouhy BJ, Wang C, Ryu SW, Neutzner A, Hasson SA, Sideris DP, Abeliovich H, Youle RJ. Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Molecular and Cellular Biology. 33: 3675-88. PMID 23878393 DOI: 10.1128/Mcb.00079-13  0.68
2013 Nezich CL, Youle RJ. Make or break for mitochondria. Elife. 2: e00804. PMID 23682317 DOI: 10.7554/Elife.00804  0.8
2013 Huang CH, Lazarou M, Youle RJ. Sequestration and autophagy of mitochondria do not cut proteins across the board. Proceedings of the National Academy of Sciences of the United States of America. 110: 6252-3. PMID 23569251 DOI: 10.1073/Pnas.1303921110  1
2013 Narendra DP, Wang C, Youle RJ, Walker JE. PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Human Molecular Genetics. 22: 2572-89. PMID 23459931 DOI: 10.1093/Hmg/Ddt106  0.68
2013 Lazarou M, Narendra DP, Jin SM, Tekle E, Banerjee S, Youle RJ. PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. The Journal of Cell Biology. 200: 163-72. PMID 23319602 DOI: 10.1083/Jcb.201210111  0.96
2012 Cooper JP, Youle RJ. Balancing cell growth and death. Current Opinion in Cell Biology. 24: 802-3. PMID 23246130 DOI: 10.1016/J.Ceb.2012.11.003  0.68
2012 Ma J, Edlich F, Bermejo GA, Norris KL, Youle RJ, Tjandra N. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. 109: 20901-6. PMID 23213219 DOI: 10.1073/Pnas.1217094110  0.68
2012 Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 109: 19426-31. PMID 23129617 DOI: 10.1073/Pnas.1217477109  0.68
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Youle RJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  1
2012 Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration Nature Cell Biology. 14: 575-583. PMID 22544066 DOI: 10.1038/Ncb2488  0.68
2012 Jin SM, Youle RJ. PINK1- and Parkin-mediated mitophagy at a glance. Journal of Cell Science. 125: 795-9. PMID 22448035 DOI: 10.1242/Jcs.093849  0.64
2012 Narendra DP, Youle RJ. Neurodegeneration: Trouble in the cell's powerhouse. Nature. 483: 418-9. PMID 22398449 DOI: 10.1038/Nature10952  0.64
2012 Sims JJ, Scavone F, Cooper EM, Kane LA, Youle RJ, Boeke JD, Cohen RE. Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nature Methods. 9: 303-9. PMID 22306808 DOI: 10.1038/Nmeth.1888  0.68
2012 Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Developmental Cell. 22: 320-33. PMID 22280891 DOI: 10.1016/J.Devcel.2011.12.014  0.96
2012 Wang C, Youle RJ. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene. 31: 3177-89. PMID 22056880 DOI: 10.1038/Onc.2011.497  1
2011 Kane LA, Youle RJ. PINK1 and Parkin flag Miro to direct mitochondrial traffic. Cell. 147: 721-3. PMID 22078873 DOI: 10.1016/J.Cell.2011.10.028  0.64
2011 Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA, Yang CY, Prater SM, Kim DH, Thompson CB, Youle RJ, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Molecular Cell. 43: 572-85. PMID 21855797 DOI: 10.1016/J.Molcel.2011.06.018  0.68
2011 Karbowski M, Youle RJ. Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Current Opinion in Cell Biology. 23: 476-82. PMID 21705204 DOI: 10.1016/J.Ceb.2011.05.007  0.36
2011 Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C, Neutzner A, Tjandra N, Youle RJ. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell. 145: 104-16. PMID 21458670 DOI: 10.1016/J.Cell.2011.02.034  0.68
2011 Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi MV, Youle RJ, et al. A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. Human Molecular Genetics. 20: 1893-905. PMID 21349918 DOI: 10.1093/Hmg/Ddr071  0.68
2011 Hoppins S, Edlich F, Cleland MM, Banerjee S, McCaffery JM, Youle RJ, Nunnari J. The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Molecular Cell. 41: 150-60. PMID 21255726 DOI: 10.1016/J.Molcel.2010.11.030  0.36
2011 Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M. A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. The Journal of Biological Chemistry. 286: 8633-43. PMID 21205830 DOI: 10.1074/Jbc.M110.197459  0.36
2011 Narendra DP, Youle RJ. Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxidants & Redox Signaling. 14: 1929-38. PMID 21194381 DOI: 10.1089/Ars.2010.3799  0.64
2011 Youle RJ, Narendra DP. Mechanisms of mitophagy. Nature Reviews. Molecular Cell Biology. 12: 9-14. PMID 21179058 DOI: 10.1038/Nrm3028  0.64
2011 Cleland MM, Norris KL, Karbowski M, Wang C, Suen DF, Jiao S, George NM, Luo X, Li Z, Youle RJ. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death and Differentiation. 18: 235-47. PMID 20671748 DOI: 10.1038/Cdd.2010.89  0.68
2010 Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. The Journal of Cell Biology. 191: 1367-80. PMID 21173115 DOI: 10.1083/Jcb.201007013  0.64
2010 Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. The Journal of Cell Biology. 191: 1141-58. PMID 21149567 DOI: 10.1083/Jcb.201007152  1
2010 Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. The Journal of Cell Biology. 191: 933-42. PMID 21115803 DOI: 10.1083/Jcb.201008084  1
2010 Narendra DP, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Autophagy. 6: 1090-1106. PMID 20890124 DOI: 10.4161/Auto.6.8.13426  0.64
2010 Kane LA, Youle RJ. Mitochondrial fission and fusion and their roles in the heart. Journal of Molecular Medicine (Berlin, Germany). 88: 971-9. PMID 20835916 DOI: 10.1007/S00109-010-0674-6  0.64
2010 Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 11835-40. PMID 20547844 DOI: 10.1073/Pnas.0914569107  0.64
2010 Du X, Youle RJ, FitzGerald DJ, Pastan I. Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Molecular and Cellular Biology. 30: 3444-52. PMID 20457813 DOI: 10.1128/Mcb.00813-09  0.68
2010 Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The Embo Journal. 29: 1458-71. PMID 20300062 DOI: 10.1038/Emboj.2010.39  1
2010 Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. Plos Biology. 8: e1000298. PMID 20126261 DOI: 10.1371/Journal.Pbio.1000298  0.68
2009 Rostovtseva TK, Boukari H, Antignani A, Shiu B, Banerjee S, Neutzner A, Youle RJ. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. The Journal of Biological Chemistry. 284: 34390-9. PMID 19805544 DOI: 10.1074/Jbc.M109.021873  0.68
2009 Wang C, Youle RJ. The role of mitochondria in apoptosis*. Annual Review of Genetics. 43: 95-118. PMID 19659442 DOI: 10.1146/Annurev-Genet-102108-134850  1
2009 Hardwick JM, Youle RJ. SnapShot: BCL-2 proteins. Cell. 138: 404, 404.e1. PMID 19632186 DOI: 10.1016/J.Cell.2009.07.003  0.68
2009 Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy. 5: 706-8. PMID 19377297 DOI: 10.4161/Auto.5.5.8505  0.36
2008 Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. The Journal of Cell Biology. 183: 795-803. PMID 19029340 DOI: 10.1083/Jcb.200809125  0.48
2008 Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes & Development. 22: 1577-90. PMID 18559474 DOI: 10.1101/Gad.1658508  0.92
2008 Norris KL, Youle RJ. Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. Journal of Virology. 82: 6232-43. PMID 18417572 DOI: 10.1128/Jvi.02710-07  0.68
2007 Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, Youle RJ, Cho H. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. The Journal of Biological Chemistry. 282: 22977-83. PMID 17545159 DOI: 10.1074/Jbc.M700679200  0.36
2007 Goyal G, Fell B, Sarin A, Youle RJ, Sriram V. Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Developmental Cell. 12: 807-16. PMID 17488630 DOI: 10.1016/J.Devcel.2007.02.002  0.68
2006 Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ. Role of Bax and Bak in mitochondrial morphogenesis. Nature. 443: 658-62. PMID 17035996 DOI: 10.1038/Nature05111  0.36
2006 Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. The Embo Journal. 25: 3900-11. PMID 16874299 DOI: 10.1038/Sj.Emboj.7601253  0.68
2006 House SB, Rusnak M, Liu XH, Youle RJ, Gainer H. Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture. Experimental Neurology. 200: 267-71. PMID 16624298 DOI: 10.1016/J.Expneurol.2006.02.009  0.68
2005 Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Molecular and Cellular Biology. 25: 9369-82. PMID 16227588 DOI: 10.1128/Mcb.25.21.9369-9382.2005  0.68
2005 Suzuki M, Neutzner A, Tjandra N, Youle RJ. Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. The Journal of Biological Chemistry. 280: 21444-52. PMID 15809300 DOI: 10.1074/Jbc.M414092200  0.68
2005 Nesic-Taylor O, Cittelly D, Ye Z, Xu GY, Unabia G, Lee JC, Svrakic NM, Liu XH, Youle RJ, Wood TG, McAdoo D, Westlund KN, Hulsebosch CE, Perez-Polo JR. Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury. Journal of Neuroscience Research. 79: 628-37. PMID 15668909 DOI: 10.1002/Jnr.20400  0.68
2004 Karbowski M, Jeong SY, Youle RJ. Endophilin B1 is required for the maintenance of mitochondrial morphology. The Journal of Cell Biology. 166: 1027-39. PMID 15452144 DOI: 10.1083/Jcb.200407046  0.36
2004 Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Molecular Biology of the Cell. 15: 5001-11. PMID 15356267 DOI: 10.1091/Mbc.E04-04-0294  0.36
2004 Jeong SY, Gaume B, Lee YJ, Hsu YT, Ryu SW, Yoon SH, Youle RJ. Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. The Embo Journal. 23: 2146-55. PMID 15131699 DOI: 10.1038/Sj.Emboj.7600225  0.36
2004 Rostovtseva TK, Antonsson B, Suzuki M, Youle RJ, Colombini M, Bezrukov SM. Bid, but not Bax, regulates VDAC channels. The Journal of Biological Chemistry. 279: 13575-83. PMID 14729675 DOI: 10.1074/Jbc.M310593200  0.68
2003 Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. Journal of Molecular Biology. 334: 445-58. PMID 14623186 DOI: 10.1016/J.Jmb.2003.09.064  0.68
2003 Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. The Embo Journal. 22: 4385-99. PMID 12941691 DOI: 10.1093/Emboj/Cdg423  0.68
2003 Karbowski M, Youle RJ. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death and Differentiation. 10: 870-80. PMID 12867994 DOI: 10.1038/Sj.Cdd.4401260  0.36
2003 Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron. 38: 899-914. PMID 12818176 DOI: 10.1016/S0896-6273(03)00355-6  0.68
2003 Santetl A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells Journal of Cell Science. 116: 2763-2774. PMID 12759376 DOI: 10.1242/Jcs.00479  0.68
2003 Smaili SS, Hsu YT, Carvalho AC, Rosenstock TR, Sharpe JC, Youle RJ. Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 36: 183-90. PMID 12563519 DOI: 10.1590/S0100-879X2003000200004  0.68
2002 Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis Journal of Cell Biology. 159: 931-938. PMID 12499352 DOI: 10.1083/Jcb.200209124  0.68
2002 De Giorgi F, Lartigue L, Bauer MKA, Schubert A, Grimm S, Hanson GT, Remington SJ, Youle RJ, Ichas F. The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 607-609. PMID 11919169 DOI: 10.1096/Fj.01-0269Fje  0.68
2002 Ichinose M, Liu XH, Hagihara N, Youle RJ. Extracellular Bad fused to toxin transport domains induces apoptosis. Cancer Research. 62: 1433-8. PMID 11888916  0.32
2002 Saxena SK, Sirdeshmukh R, Ardelt W, Mikulski SM, Shogen K, Youle RJ. Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. The Journal of Biological Chemistry. 277: 15142-6. PMID 11839736 DOI: 10.1074/jbc.M108115200  0.68
2001 Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, Smith CL, Youle RJ. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Developmental Cell. 1: 515-25. PMID 11703942 DOI: 10.1016/S1534-5807(01)00055-7  0.36
2001 Liu XH, Collier RJ, Youle RJ. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. The Journal of Biological Chemistry. 276: 46326-32. PMID 11574549 DOI: 10.1074/Jbc.M108930200  0.68
2001 Smaili SS, Hsu YT, Sanders KM, Russell JT, Youle RJ. Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential. Cell Death and Differentiation. 8: 909-20. PMID 11526446 DOI: 10.1038/sj.cdd.4400889  0.68
2001 Nechushtan A, Smith CL, Lamensdorf I, Yoon SH, Youle RJ. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. The Journal of Cell Biology. 153: 1265-76. PMID 11402069 DOI: 10.1083/Jcb.153.6.1265  0.36
2001 Richter BW, Mir SS, Eiben LJ, Lewis J, Reffey SB, Frattini A, Tian L, Frank S, Youle RJ, Nelson DL, Notarangelo LD, Vezzoni P, Fearnhead HO, Duckett CS. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Molecular and Cellular Biology. 21: 4292-301. PMID 11390657 DOI: 10.1128/Mcb.21.13.4292-4301.2001  0.68
2001 Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR. Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors. The Journal of Biological Chemistry. 276: 15009-17. PMID 11154698 DOI: 10.1074/Jbc.M010585200  0.68
2000 Smaili SS, Hsu YT, Youle RJ, Russell JT. Mitochondria in Ca2+ signaling and apoptosis. Journal of Bioenergetics and Biomembranes. 32: 35-46. PMID 11768760 DOI: 10.1023/A:1005508311495  0.68
1984 Quinones RR, Youle RJ, Kersey JH, Zanjani ED, Azemove SM, Soderling CC, Lebien TW, Beverley PC, Neville DM, Vallera DA. Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow. Journal of Immunology (Baltimore, Md. : 1950). 132: 678-83. PMID 6606676  0.68
1984 Filipovich AH, Vallera DA, Youle RJ, Quinones RR, Neville DM, Kersey JH. Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease. Lancet (London, England). 1: 469-72. PMID 6142206 DOI: 10.1016/S0140-6736(84)92847-2  0.88
1983 Vallera DA, Ash RC, Zanjani ED, Kersey JH, Lebien TW, Beverley PCL, Neville DM, Youle RJ. Anti-T-Cell reagents for human bone marrow transplantation: Ricin linked to three monoclonal antibodies Science. 222: 512-515. PMID 6353579 DOI: 10.1126/Science.6353579  0.68
1983 Vallera DA, Youle RJ, Neville DM, Soderling CCB, Kersey JH. Monoclonal antibody toxin conjugates for experimental graft-versus-host disease prophylaxis: Reagents selectively reactive with t cells and not murine stem cells Transplantation. 36: 73-80. PMID 6346616 DOI: 10.1097/00007890-198307000-00015  0.68
1982 Neville DM, Youle RJ. Monoclonal antibody-ricin or ricin A chain hybrids: kinetic analysis of cell killing for tumor therapy. Immunological Reviews. 62: 75-91. PMID 7042541 DOI: 10.1111/J.1600-065X.1982.Tb00390.X  0.56
1982 Vallera DA, Youle RJ, Neville DM, Kersey JH. Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin Journal of Experimental Medicine. 155: 949-954. PMID 6120991 DOI: 10.1084/jem.155.3.949  0.68
1982 Youle RJ, Neville DM. Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution. The Journal of Biological Chemistry. 257: 1598-601. PMID 6120167  0.88
1981 Youle RJ, Murray GJ, Neville DM. Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin Cell. 23: 551-559. PMID 7471212 DOI: 10.1016/0092-8674(81)90151-3  0.68
1981 Youle RJ, Neville DM. Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin. Proceedings of the National Academy of Sciences of the United States of America. 77: 5483-6. PMID 6968914 DOI: 10.1073/Pnas.77.9.5483  0.56
1981 Robbins AR, Myerowitz R, Youle RJ, Murray GJ, Neville DM. The mannose 6-phosphate receptor of Chinese hamster ovary cells. Isolation of mutants with altered receptors Journal of Biological Chemistry. 256: 10618-10622. PMID 6270122  0.68
1980 Neville DM, Murray GJ, Youle RJ. Directed entry of hybrid proteins into cells via alternative receptors Biochemical Society Transactions. 8: 692-693. PMID 7461253 DOI: 10.1042/Bst0080692  0.68
1979 Youle RJ, Neville DM. Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II. The Journal of Biological Chemistry. 254: 11089-96. PMID 500625  0.88
1979 Youle RJ, Murray GJ, Neville DM. Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin Proceedings of the National Academy of Sciences of the United States of America. 76: 5559-5562. PMID 293662 DOI: 10.1073/Pnas.76.11.5559  0.68
1978 Youle RJ, Huang AH. Evidence that the castor bean allergens are the albumin storage proteins in the protein bodies of castor bean. Plant Physiology. 61: 1040-2. PMID 16660413  0.36
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