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Joel L. Sussman - Publications

Affiliations: 
Structural Biology Weizmann Institute 
Area:
3D structure/function of nervous system proteins
Website:
http://www.weizmann.ac.il/home/jsgrp/group/joel.html

216 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chandar NB, Efremenko I, Silman I, Martin JML, Sussman JL. Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design. Chemico-Biological Interactions. PMID 31226285 DOI: 10.1016/j.cbi.2019.06.028  1
2019 Novichkova DA, Lushchekina SV, Dym O, Masson P, Silman I, Sussman JL. The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability. Chemico-Biological Interactions. PMID 31202688 DOI: 10.1016/j.cbi.2019.06.012  1
2019 Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, et al. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European Journal of Medicinal Chemistry. 168: 58-77. PMID 30798053 DOI: 10.1016/j.ejmech.2018.12.063  1
2018 Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T. Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly. Proceedings of the National Academy of Sciences of the United States of America. PMID 30538207 DOI: 10.1073/pnas.1817009115  1
2018 Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F. Structure-based optimization of non-quaternary reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Journal of Medicinal Chemistry. PMID 30125110 DOI: 10.1021/acs.jmedchem.8b00592  1
2018 Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. 70: 380. PMID 29677494 DOI: 10.1016/j.molcel.2018.03.035  1
2018 Zorbaz T, Braïki A, Marakovic N, Renou J, de la Mora E, Marek Hrvat N, Katalinic M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Perez B, Baati R, Nachon F, et al. Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29672968 DOI: 10.1002/chem.201801394  1
2017 Xu Y, Cheng S, Sussman JL, Silman I, Jiang H. Computational Studies on Acetylcholinesterases. Molecules (Basel, Switzerland). 22. PMID 28796192 DOI: 10.3390/molecules22081324  1
2017 Silman I, Sussman JL. Recent developments in structural studies on acetylcholinesterase. Journal of Neurochemistry. PMID 28503857 DOI: 10.1111/jnc.13992  1
2017 Goldsmith M, Aggarwal N, Ashani Y, Jubran H, Greisen PJ, Ovchinnikov S, Leader H, Baker D, Sussman JL, Goldenzweig A, Fleishman SJ, Tawfik DS. Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers. Protein Engineering, Design & Selection : Peds. 1-13. PMID 28159998 DOI: 10.1093/protein/gzx003  0.36
2016 Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. PMID 27425410 DOI: 10.1016/j.molcel.2016.06.012  1
2016 Wille T, Neumaier K, Koller M, Ehinger C, Aggarwal N, Ashani Y, Goldsmith M, Sussman JL, Tawfik DS, Thiermann H, Worek F. Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection. Toxicology Letters. PMID 27397758 DOI: 10.1016/j.toxlet.2016.07.004  1
2016 Ashani Y, Leader H, Aggarwal N, Silman I, Worek F, Sussman JL, Goldsmith M. In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications. Chemico-Biological Interactions. PMID 27163850 DOI: 10.1016/j.cbi.2016.04.039  1
2016 Dym O, Song W, Felder C, Roth E, Shnyrov V, Ashani Y, Xu Y, Joosten RP, Weiner L, Sussman JL, Silman I. The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue/Acetylcholinesterase Complex. Protein Science : a Publication of the Protein Society. PMID 26990888 DOI: 10.1002/pro.2923  1
2015 Goldsmith M, Eckstein S, Ashani Y, Greisen P, Leader H, Sussman JL, Aggarwal N, Ovchinnikov S, Tawfik DS, Baker D, Thiermann H, Worek F. Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro. Archives of Toxicology. PMID 26612364 DOI: 10.1007/s00204-015-1626-2  0.36
2015 Ben-David M, Sussman JL, Maxwell CI, Szeler K, Kamerlin SC, Tawfik DS. Catalytic stimulation by restrained active-site floppiness--the case of high density lipoprotein-bound serum paraoxonase-1. Journal of Molecular Biology. 427: 1359-74. PMID 25644661 DOI: 10.1016/j.jmb.2015.01.013  0.36
2014 Worek F, Seeger T, Reiter G, Goldsmith M, Ashani Y, Leader H, Sussman JL, Aggarwal N, Thiermann H, Tawfik DS. Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study. Toxicology Letters. 231: 45-54. PMID 25195526 DOI: 10.1016/j.toxlet.2014.09.003  1
2013 Dunker AK, Babu MM, Barbar E, Blackledge M, Bondos SE, Dosztányi Z, Dyson HJ, Forman-Kay J, Fuxreiter M, Gsponer J, Han KH, Jones DT, Longhi S, Metallo SJ, Nishikawa K, ... ... Sussman JL, et al. What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered. Intrinsically Disordered Proteins. 1: e24157. PMID 28516007 DOI: 10.4161/idp.24157  0.44
2013 Ben-David M, Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS. Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. Journal of Molecular Biology. 425: 1028-38. PMID 23318950 DOI: 10.1016/j.jmb.2013.01.009  1
2013 Silman I, Roth E, Paz A, Triquigneaux MM, Ehrenshaft M, Xu Y, Shnyrov VL, Sussman JL, Deterding LJ, Ashani Y, Mason RP, Weiner L. The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy. Chemico-Biological Interactions. 203: 63-6. PMID 23159732 DOI: 10.1016/j.cbi.2012.10.021  1
2013 Offman MN, Silman I, Sussman JL, Futerman AH. Crystal structure of the enzyme acid b-glucosidase Advances in Gaucher Disease: Basic and Clinical Perspectives. 125-138. DOI: 10.2217/EBO.12.215  1
2013 Prilusky J, Sussman JL. Guest editorial: Databases and bioinformatics tools Israel Journal of Chemistry. 53: 143. DOI: 10.1002/ijch.201310004  1
2013 Hanson RM, Prilusky J, Renjian Z, Nakane T, Sussman JL. JSmol and the next-generation web-based representation of 3D molecular structure as applied to proteopedia Israel Journal of Chemistry. 53: 207-216. DOI: 10.1002/ijch.201300024  1
2012 Paz A, Roth E, Ashani Y, Xu Y, Shnyrov VL, Sussman JL, Silman I, Weiner L. Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase. Protein Science : a Publication of the Protein Society. 21: 1138-52. PMID 22674800 DOI: 10.1002/pro.2101  1
2012 Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS. Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification. Chemistry & Biology. 19: 456-66. PMID 22520752 DOI: 10.1016/j.chembiol.2012.01.017  1
2012 Greenblatt HM, Otto TC, Kirkpatrick MG, Kovaleva E, Brown S, Buchman G, Cerasoli DM, Sussman JL. Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 269-72. PMID 22442219 DOI: 10.1107/S1744309112003326  1
2012 Acheampong MG, Dueño DE, Glover BK, Henry AA, Mata R, Vanbrakle ML, Westblade LF, Sussman JL, Granberry AL. Acetylcholinesterase: substrate traffic and inhibition. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 40: 144. PMID 22419598 DOI: 10.1002/bmb.20604  1
2012 Ben-David M, Elias M, Filippi JJ, Duñach E, Silman I, Sussman JL, Tawfik DS. Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. Journal of Molecular Biology. 418: 181-96. PMID 22387469 DOI: 10.1016/j.jmb.2012.02.042  1
2012 Khare SD, Kipnis Y, Greisen P, Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H, Sussman JL, Stoddard BL, Tawfik DS, Baker D. Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nature Chemical Biology. 8: 294-300. PMID 22306579 DOI: 10.1038/nchembio.777  1
2012 Xu Y, Li MJ, Greenblatt H, Chen W, Paz A, Dym O, Peleg Y, Chen T, Shen X, He J, Jiang H, Silman I, Sussman JL. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations. Acta Crystallographica. Section D, Biological Crystallography. 68: 13-25. PMID 22194329 DOI: 10.1107/S0907444911047251  1
2012 Wood K, Paz A, Dijkstra K, Scheek RM, Otten R, Silman I, Sussman JL, Mulder FA. Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3. Biomolecular Nmr Assignments. 6: 15-8. PMID 21647611 DOI: 10.1007/s12104-011-9315-4  1
2012 Prilusky J, Hodis E, Sussman JL. Proteopedia: Exciting advances in the 3D encyclopedia of biomolecular structure Nato Science For Peace and Security Series a: Chemistry and Biology. 149-161. DOI: 10.1007/978-94-007-2530-0_14  1
2011 Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS. In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases. Toxicology Letters. 206: 24-8. PMID 21807078 DOI: 10.1016/j.toxlet.2011.07.017  1
2011 Offman MN, Krol M, Rost B, Silman I, Sussman JL, Futerman AH. Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease. Protein Engineering, Design & Selection : Peds. 24: 773-5. PMID 21724649 DOI: 10.1093/protein/gzr032  1
2011 Perrakis A, Daenke S, Stuart DI, Sussman JL. From SPINE to SPINE-2 complexes and beyond Journal of Structural Biology. 175: 105. PMID 21619933 DOI: 10.1016/j.jsb.2011.05.013  1
2011 Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M. Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations Protein Science. 20: 1114-1118. PMID 21594947 DOI: 10.1002/pro.661  1
2011 Suskiewicz MJ, Sussman JL, Silman I, Shaul Y. Context-dependent resistance to proteolysis of intrinsically disordered proteins Protein Science. 20: 1285-1297. PMID 21574196 DOI: 10.1002/pro.657  1
2011 Prilusky J, Hodis E, Canner D, Decatur WA, Oberholser K, Martz E, Berchanski A, Harel M, Sussman JL. Proteopedia: A status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules Journal of Structural Biology. 175: 244-252. PMID 21536137 DOI: 10.1016/j.jsb.2011.04.011  1
2011 Brumshtein B, Aguilar-Moncayo M, Benito JM, García Fernandez JM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH, Ortiz Mellet C. Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues Organic and Biomolecular Chemistry. 9: 4160-4167. PMID 21483943 DOI: 10.1039/c1ob05200d  1
2011 Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: the basis for designing a new class of selective estrogen receptor modulators. Journal of Medicinal Chemistry. 54: 3575-80. PMID 21473635 DOI: 10.1021/jm200192y  1
2011 Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, ... ... Sussman JL, et al. Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study. Journal of Structural Biology. 175: 159-70. PMID 21382497 DOI: 10.1016/j.jsb.2011.03.004  1
2011 Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS. Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nature Chemical Biology. 7: 120-5. PMID 21217689 DOI: 10.1038/nchembio.510  1
2010 Hodis E, Prilusky J, Sussman JL. Proteopedia: A collaborative, virtual 3D web-resource for protein and biomolecule structure and function. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 38: 341-2. PMID 21567857 DOI: 10.1002/bmb.20431  0.64
2010 Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL. Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase Biophysical Journal. 99: 4003-4011. PMID 21156143 DOI: 10.1016/j.bpj.2010.10.047  1
2010 Offman MN, Krol M, Silman I, Sussman JL, Futerman AH. Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S Journal of Biological Chemistry. 285: 42105-42114. PMID 20980259 DOI: 10.1074/jbc.M110.172098  1
2010 Albeck S, Nordlund P, Sussman JL. New trends in protein expression Journal of Structural Biology. 172: 1-2. PMID 20691273 DOI: 10.1016/j.jsb.2010.08.001  1
2010 Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H. Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers. Chemico-Biological Interactions. 187: 362-9. PMID 20303930 DOI: 10.1016/j.cbi.2010.02.039  1
2010 Dvir H, Silman I, Harel M, Rosenberry TL, Sussman JL. Acetylcholinesterase: From 3D structure to function Chemico-Biological Interactions. 187: 10-22. PMID 20138030 DOI: 10.1016/j.cbi.2010.01.042  1
2010 Brumshtein B, Salinas P, Peterson B, Chan V, Silman I, Sussman JL, Savickas PJ, Robinson GS, Futerman AH. Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages Glycobiology. 20: 24-32. PMID 19741058 DOI: 10.1093/glycob/cwp138  1
2010 Hodis E, Prilusky J, Sussman JL. Proteopedia: A collaborative, virtual 3D web-resource for protein and biomolecule structure and function Biochemistry and Molecular Biology Education. 38: 341-342. DOI: 10.1002/bmb.20431  1
2010 Paz A, Zeev-Ben-Mordehai T, Sussman JL, Silman I. Purification of Intrinsically Disordered Proteins Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation. 695-704. DOI: 10.1002/9780470602614.ch24  1
2009 Zeev-Ben-Mordehai T, Mylonas E, Paz A, Peleg Y, Toker L, Silman I, Svergun DI, Sussman JL. The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties. Biophysical Journal. 97: 2316-26. PMID 19843464 DOI: 10.1016/j.bpj.2009.07.045  0.48
2009 Noivirt-Brik O, Prilusky J, Sussman JL. Assessment of disorder predictions in CASP8. Proteins. 77: 210-6. PMID 19774619 DOI: 10.1002/prot.22586  0.64
2009 Ben-David M, Noivirt-Brik O, Paz A, Prilusky J, Sussman JL, Levy Y. Assessment of CASP8 structure predictions for template free targets. Proteins. 77: 50-65. PMID 19774550 DOI: 10.1002/prot.22591  1
2009 Sharabi O, Peleg Y, Mashiach E, Vardy E, Ashani Y, Simian I, Sussman JL, Shifman JM. Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase Protein Engineering, Design and Selection. 22: 641-648. PMID 19643977 DOI: 10.1093/protein/gzp045  1
2009 Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M. Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime Journal of Medicinal Chemistry. 52: 7593-7603. PMID 19642642 DOI: 10.1021/jm900433t  0.48
2009 Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS. Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization Biochemistry. 48: 6644-6654. PMID 19492856 DOI: 10.1021/bi900583y  0.48
2009 Brumshtein B, Aguilar-Moncayo M, García-Moreno IM, Mellet CO, Fernández JGM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH. 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene) nojirimycin: Synthesis, biological evaluation, and crystal structure in complex with acid β-glucosidase Chembiochem. 10: 1480-1485. PMID 19437524 DOI: 10.1002/cbic.200900142  1
2009 Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL. The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad. Journal of Medicinal Chemistry. 52: 2543-9. PMID 19326912 DOI: 10.1021/jm801657v  1
2009 Hodis E, Sussman JL. An encyclopedic effort to make 3D structures easier to understand Trends in Biochemical Sciences. 34: 100-101. PMID 19230677 DOI: 10.1016/j.tibs.2009.01.001  1
2009 Zeev-Ben-Mordehai T, Paz A, Peleg Y, Toker L, Wolf SG, Rydberg EH, Sussman JL, Silman I. Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. Protein Expression and Purification. 63: 147-57. PMID 18938249 DOI: 10.1016/j.pep.2008.09.019  0.48
2009 Sussman JL, Silman I. Structural studies on acetylcholinesterase and paraoxonase directed towards development of therapeutic biomolecules for the treatment of degenerative diseases and protection against chemical threat agents Nato Science For Peace and Security Series a: Chemistry and Biology. 183-199. DOI: 10.1007/978-90-481-2339-1-12  1
2009 Hodis E, Prilusky J, Sussman JL. Tools to make 3D structural data more comprehensible: eMovie & Proteopedia Nato Science For Peace and Security Series a: Chemistry and Biology. 169-182. DOI: 10.1007/978-90-481-2339-1-11  1
2009 Noivirt-Brik O, Prilusky J, Sussman JL. Assessment of disorder predictions in CASP8 Proteins: Structure, Function and Bioinformatics. 77: 210-216. DOI: 10.1002/prot.22586  1
2009 Sussman JL, Spadon P. Structure of biological macromolecules and its relevance in combating new diseases and bioterrorism Nato Security Through Science Series C: Environmental Security. vii.  1
2008 Brumshtein B, Greenblatt HM, Futerman AH, Silman I, Sussman JL. Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method. Journal of Applied Crystallography. 41: 969-971. PMID 19461852 DOI: 10.1107/S0021889808024667  1
2008 Dunker AK, Silman I, Uversky VN, Sussman JL. Function and structure of inherently disordered proteins Current Opinion in Structural Biology. 18: 756-764. PMID 18952168 DOI: 10.1016/j.sbi.2008.10.002  1
2008 Kacher Y, Brumshtein B, Boldin-Adamsky S, Toker L, Shainskaya A, Silman I, Sussman JL, Futerman AH. Acid β-glucosidase: Insights from structural analysis and relevance to Gaucher disease therapy Biological Chemistry. 389: 1361-1369. PMID 18783340 DOI: 10.1515/BC.2008.163  0.48
2008 Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M. Shoot-and-trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography Proceedings of the National Academy of Sciences of the United States of America. 105: 11742-11747. PMID 18701720 DOI: 10.1073/pnas.0804828105  1
2008 Hodis E, Prilusky J, Martz E, Silman I, Moult J, Sussman JL. Proteopedia - A scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules Genome Biology. 9. PMID 18673581 DOI: 10.1186/gb-2008-9-8-r121  1
2008 Silman I, Sussman JL. Acetylcholinesterase: How is structure related to function? Chemico-Biological Interactions. 175: 3-10. PMID 18586019 DOI: 10.1016/j.cbi.2008.05.035  1
2008 Meged R, Dym O, Sussman JL. High throughput pH optimization of protein crystallization. Methods in Molecular Biology (Clifton, N.J.). 426: 411-418. PMID 18542880  1
2008 Harel M, Sonoda LK, Silman I, Sussman JL, Rosenberry TL. Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site Journal of the American Chemical Society. 130: 7856-7861. PMID 18512913 DOI: 10.1021/ja7109822  1
2008 Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL. Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics Biophysical Journal. 95: 2500-2511. PMID 18502801 DOI: 10.1529/biophysj.108.129601  1
2008 Paz A, Zeev-Ben-Mordehai T, Lundqvist M, Sherman E, Mylonas E, Weiner L, Haran G, Svergun DI, Mulder FA, Sussman JL, Silman I. Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophysical Journal. 95: 1928-44. PMID 18456828 DOI: 10.1529/biophysj.107.126995  1
2008 Manicka S, Peleg Y, Unger T, Albeck S, Dym O, Greenblatt HM, Bourenkov G, Lamzin V, Krishnaswamy S, Sussman JL. Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12. Proteins. 71: 2102-8. PMID 18361457 DOI: 10.1002/prot.22023  1
2008 Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M. Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design Protein Science. 17: 601-605. PMID 18359854 DOI: 10.1110/ps.083453808  1
2008 Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, ... ... Sussman JL, et al. Protein production and purification. Nature Methods. 5: 135-46. PMID 18235434 DOI: 10.1038/nmeth.f.202  1
2008 Tompa P, Prilusky J, Silman I, Sussman JL. Structural disorder serves as a weak signal for intracellular protein degradation Proteins: Structure, Function and Genetics. 71: 903-909. PMID 18004785 DOI: 10.1002/prot.21773  1
2008 Tsvetkov P, Asher G, Paz A, Reuven N, Sussman JL, Silman I, Shaul Y. Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome Proteins: Structure, Function and Genetics. 70: 1357-1366. PMID 17879262 DOI: 10.1002/prot.21614  1
2008 Brumshtein B, Greenblatt HM, Futerman AH, Silman I, Sussman JL. Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method Journal of Applied Crystallography. 41: 969-971. DOI: 10.1107/S0021889808024667  1
2007 Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I, Bourgeois D, Weik M. Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Acta Crystallographica. Section D, Biological Crystallography. 63: 1115-28. PMID 18007027 DOI: 10.1107/S0907444907044472  1
2007 Banci L, Baumeister W, Heinemann U, Schneider G, Silman I, Stuart DI, Sussman JL. An idea whose time has come. Genome Biology. 8: 408. PMID 18001498 DOI: 10.1186/gb-2007-8-11-408  1
2007 Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RBG, McCarthy A, Toker L, Silman I, Sussman JL. 3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability Arhiv Za Higijenu Rada I Toksikologiju. 58: 347-353. PMID 17913690 DOI: 10.2478/v10004-007-0028-0  0.48
2007 Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL. Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid β-glucosidase: Insights into the mechanism of chemical chaperone action in Gaucher disease Journal of Biological Chemistry. 282: 29052-29058. PMID 17666401 DOI: 10.1074/jbc.M705005200  1
2007 Felder CE, Prilusky J, Silman I, Sussman JL. A server and database for dipole moments of proteins. Nucleic Acids Research. 35: W512-21. PMID 17526523 DOI: 10.1093/nar/gkm307  1
2007 Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D. Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnology Journal. 5: 579-90. PMID 17524049 DOI: 10.1111/j.1467-7652.2007.00263.x  1
2007 Hodis E, Schreiber G, Rother K, Sussman JL. eMovie: a storyboard-based tool for making molecular movies Trends in Biochemical Sciences. 32: 199-204. PMID 17448663 DOI: 10.1016/j.tibs.2007.03.008  1
2007 Haviv H, Wong DM, Silman I, Sussman JL. Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors Current Topics in Medicinal Chemistry. 7: 375-387. PMID 17305579 DOI: 10.2174/156802607779941215  1
2007 Banci L, Baumeister W, Enfedaque J, Heinemann U, Schneider G, Silman I, Sussman JL. Structural proteomics: from the molecule to the system. Nature Structural & Molecular Biology. 14: 3-4. PMID 17203065 DOI: 10.1038/nsmb0107-3  1
2007 Yokoyama S, Terwilliger TC, Kuramitsu S, Moras D, Sussman JL. RIKEN aids international structural genomics efforts. Nature. 445: 21. PMID 17203040 DOI: 10.1038/445021a  1
2007 Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D. Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system Plant Biotechnology Journal. 5: 579-590. DOI: 10.1111/j.1467-7652.2007.00263.x  1
2007 Felder CE, Prilusky J, Silman I, Sussman JL. A server and database for dipole moments of proteins Nucleic Acids Research. 35: W512-W521. DOI: 10.1093/nar/gkm307  1
2007 Man O, Sussman JL, Pilpel Y. Examination of the tRNA adaptation index as a predictor of protein expression levels Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 4023: 107-118.  1
2006 Brumshtein B, Wormald MR, Silman I, Futerman AH, Sussman JL. Structural comparison of differently glycosylated forms of acid-β-glucosidase, the defective enzyme in Gaucher disease Acta Crystallographica Section D: Biological Crystallography. 62: 1458-1465. PMID 17139081 DOI: 10.1107/S0907444906038303  1
2006 Esnouf RM, Hamer R, Sussman JL, Silman I, Trudgian D, Yang ZR, Prilusky J. Honing the in silico toolkit for detecting protein disorder Acta Crystallographica Section D: Biological Crystallography. 62: 1260-1266. PMID 17001103 DOI: 10.1107/S0907444906033580  1
2006 Romier C, Ben Jelloul M, Albeck S, Buchwald G, Busso D, Celie PH, Christodoulou E, De Marco V, van Gerwen S, Knipscheer P, Lebbink JH, Notenboom V, Poterszman A, Rochel N, Cohen SX, ... ... Sussman JL, et al. Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies. Acta Crystallographica. Section D, Biological Crystallography. 62: 1232-42. PMID 17001100 DOI: 10.1107/S0907444906031003  1
2006 Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, ... ... Sussman JL, et al. First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. Acta Crystallographica. Section D, Biological Crystallography. 62: 1208-17. PMID 17001097 DOI: 10.1107/S0907444906029350  1
2006 Albeck S, Alzari P, Andreini C, Banci L, Berry IM, Bertini I, Cambillau C, Canard B, Carter L, Cohen SX, Diprose JM, Dym O, Esnouf RM, Felder C, Ferron F, ... ... Sussman JL, et al. SPINE bioinformatics and data-management aspects of high-throughput structural biology. Acta Crystallographica. Section D, Biological Crystallography. 62: 1184-95. PMID 17001095 DOI: 10.1107/S090744490602991X  1
2006 Berry IM, Dym O, Esnouf RM, Harlos K, Meged R, Perrakis A, Sussman JL, Walter TS, Wilson J, Messerschmidt A. SPINE high-throughput crystallization, crystal imaging and recognition techniques: Current state, performance analysis, new technologies and future aspects Acta Crystallographica Section D: Biological Crystallography. 62: 1137-1149. PMID 17001091 DOI: 10.1107/S090744490602943X  1
2006 Aricescu AR, Assenberg R, Bill RM, Busso D, Chang VT, Davis SJ, Dubrovsky A, Gustafsson L, Hedfalk K, Heinemann U, Jones IM, Ksiazek D, Lang C, Maskos K, Messerschmidt A, ... ... Sussman JL, et al. Eukaryotic expression: developments for structural proteomics. Acta Crystallographica. Section D, Biological Crystallography. 62: 1114-24. PMID 17001089 DOI: 10.1107/S0907444906029805  1
2006 Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. Journal of Medicinal Chemistry. 49: 5491-500. PMID 16942022 DOI: 10.1021/jm060164b  1
2006 Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M. Structural insights into substrate traffic and inhibition in acetylcholinesterase Embo Journal. 25: 2746-2756. PMID 16763558 DOI: 10.1038/sj.emboj.7601175  1
2006 Sussman JL, Silman I. Shedding UV Light on the Phase Problem Structure. 14: 629-630. PMID 16615902 DOI: 10.1016/j.str.2006.03.004  1
2006 Srividhya KV, Rao GV, Raghavenderan L, Mehta P, Prilusky J, Manicka S, Sussman JL, Krishnaswamy S. Database and comparative identification of prophages Lecture Notes in Control and Information Sciences. 344: 863-868. DOI: 10.1007/11816492_110  1
2005 Niu C, Xu Y, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, Jiang H. Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation. The Journal of Physical Chemistry. B. 109: 23730-8. PMID 16375354 DOI: 10.1021/jp0552877  1
2005 Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase Chemico-Biological Interactions. 157: 153-157. PMID 16289500 DOI: 10.1016/j.cbi.2005.10.016  1
2005 Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Chemico-Biological Interactions. 157: 247-52. PMID 16257398 DOI: 10.1016/j.cbi.2005.10.033  1
2005 Newman J, Egan D, Walter TS, Meged R, Berry I, Jelloul MB, Sussman JL, Stuart DI, Perrakis A. Towards rationalization of crystallization screening for small- To medium-sized academic laboratories: The PACT/JCSG+ strategy Acta Crystallographica Section D: Biological Crystallography. 61: 1426-1431. PMID 16204897 DOI: 10.1107/S0907444905024984  1
2005 Albeck S, Burstein Y, Dym O, Jacobovitch Y, Levi N, Meged R, Michael Y, Peleg Y, Prilusky J, Schreiber G, Silman I, Unger T, Sussman JL. Three-dimensional structure determination of proteins related to human health in their functional context at the Israel Structural Proteomics Center (ISPC) Acta Crystallographica Section D: Biological Crystallography. 61: 1364-1372. PMID 16204888 DOI: 10.1107/S0907444905023565  1
2005 Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL. Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase Journal of the American Chemical Society. 127: 11029-11036. PMID 16076210 DOI: 10.1021/ja051765f  1
2005 Hasin Y, Avidan N, Bercovich D, Korczyn AD, Silman I, Beckmann JS, Sussman JL. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer Research. 2: 207-18. PMID 15974920 DOI: 10.2174/1567205053585909  1
2005 Prilusky J, Felder CE, Zeev-Ben-Mordehai T, Rydberg EH, Man O, Beckmann JS, Silman I, Sussman JL. FoldIndex©: A simple tool to predict whether a given protein sequence is intrinsically unfolded Bioinformatics. 21: 3435-3438. PMID 15955783 DOI: 10.1093/bioinformatics/bti537  1
2005 Prilusky J, Oueillet E, Ulryck N, Pajon A, Bernauer J, Krimm I, Quevillon-Cheruel S, Leulliot N, Graille M, Liger D, Trésaugues L, Sussman JL, Janin J, van Tilbeurgh H, Poupon A. HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories. Acta Crystallographica. Section D, Biological Crystallography. 61: 671-8. PMID 15930618 DOI: 10.1107/S0907444905001290  1
2005 Silman I, Sussman JL. Acetylcholinesterase: 'Classical' and 'non-classical' functions and pharmacology Current Opinion in Pharmacology. 5: 293-302. PMID 15907917 DOI: 10.1016/j.coph.2005.01.014  1
2005 Premkumar L, Greenblatt HM, Bageshwar UK, Savchenko T, Gokhman I, Sussman JL, Zamir A. Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog. Proceedings of the National Academy of Sciences of the United States of America. 102: 7493-8. PMID 15894606 DOI: 10.1073/pnas.0502829102  1
2005 Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. The Journal of Biological Chemistry. 280: 23815-9. PMID 15817452 DOI: 10.1074/jbc.M502799200  0.48
2005 Jaakola VP, Prilusky J, Sussman JL, Goldman A. G protein-coupled receptors show unusual patterns of intrinsic unfolding. Protein Engineering, Design & Selection : Peds. 18: 103-10. PMID 15790574 DOI: 10.1093/protein/gzi004  1
2005 Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Molecular Pharmacology. 67: 1874-81. PMID 15772291 DOI: 10.1124/mol.104.009944  1
2005 Niu C, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, Jiang H. Dynamic mechanism of E2020 binding to acetylcholinesterase: A steered molecular dynamics simulation Journal of Physical Chemistry B. 109: 23730-23738. DOI: 10.1021/jp0552877  1
2004 Greenblatt HM, Guillou C, Guénard D, Argaman A, Botti S, Badet B, Thal C, Silman I, Sussman JL. The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. Journal of the American Chemical Society. 126: 15405-11. PMID 15563167 DOI: 10.1021/ja0466154  1
2004 Dvir H, Harel M, Bon S, Liu WQ, Vidal M, Garbay C, Sussman JL, Massoulié J, Silman I. The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. The Embo Journal. 23: 4394-405. PMID 15526038 DOI: 10.1038/sj.emboj.7600425  1
2004 Hasin Y, Avidan N, Bercovich D, Korczyn A, Silman I, Beckmann JS, Sussman JL. A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Human Mutation. 24: 408-16. PMID 15459952 DOI: 10.1002/humu.20106  1
2004 Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nature Structural & Molecular Biology. 11: 412-9. PMID 15098021 DOI: 10.1038/nsmb767  0.48
2004 Bageshwar UK, Premkumar L, Gokhman I, Savchenko T, Sussman JL, Zamir A. Natural protein engineering: a uniquely salt-tolerant, but not halophilic, alpha-type carbonic anhydrase from algae proliferating in low- to hyper-saline environments. Protein Engineering, Design & Selection : Peds. 17: 191-200. PMID 15047915 DOI: 10.1093/protein/gzh022  1
2004 Futerman AH, Sussman JL, Horowitz M, Silman I, Zimran A. New directions in the treatment of Gaucher disease. Trends in Pharmacological Sciences. 25: 147-51. PMID 15019270 DOI: 10.1016/j.tips.2004.01.004  1
2004 Pe'er I, Felder CE, Man O, Silman I, Sussman JL, Beckmann JS. Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla. Proteins. 54: 20-40. PMID 14705021 DOI: 10.1002/prot.10559  1
2004 Liu T, Zhu W, Gu J, Shen J, Luo X, Chen G, Puah CM, Silman I, Chen K, Sussman JL, Jiang H. Additivity of cation-π interactions: An ab initio computational study on π- Cation-π sandwich complexes Journal of Physical Chemistry A. 108: 9400-9405. DOI: 10.1021/jp0476850  1
2003 Xu Y, Shen J, Luo X, Silman I, Sussman JL, Chen K, Jiang H. How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations. Journal of the American Chemical Society. 125: 11340-9. PMID 16220957 DOI: 10.1021/ja029775t  1
2003 Fuchs S, Kasher R, Balass M, Scherf T, Harel M, Fridkin M, Sussman JL, Katchalski-Katzir E. The binding site of acetylcholine receptor: from synthetic peptides to solution and crystal structure. Annals of the New York Academy of Sciences. 998: 93-100. PMID 14592866 DOI: 10.1196/annals.1254.011  1
2003 Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Auld VJ, Silman I, Botti S, Sussman JL. The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded. Proteins. 53: 758-67. PMID 14579366 DOI: 10.1002/prot.10471  0.48
2003 Greenblatt HM, Dvir H, Silman I, Sussman JL. Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 20: 369-83. PMID 14501022 DOI: 10.1385/JMN:20:3:369  1
2003 Dvir H, Harel M, McCarthy AA, Toker L, Silman I, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. Embo Reports. 4: 704-9. PMID 12792654 DOI: 10.1038/sj.embor.embor873  0.48
2003 Premkumar L, Greenblatt HM, Bageshwar UK, Savchenko T, Gokhman I, Zamir A, Sussman JL. Identification, cDNA cloning, expression, crystallization and preliminary X-ray analysis of an exceptionally halotolerant carbonic anhydrase from Dunaliella salina. Acta Crystallographica. Section D, Biological Crystallography. 59: 1084-6. PMID 12777782 DOI: 10.1107/S0907444903007066  1
2003 Premkumar L, Bageshwar UK, Gokhman I, Zamir A, Sussman JL. An unusual halotolerant alpha-type carbonic anhydrase from the alga Dunaliella salina functionally expressed in Escherichia coli. Protein Expression and Purification. 28: 151-7. PMID 12651119 DOI: 10.1016/S1046-5928(02)00683-6  1
2003 Katchalski-Katzir E, Kasher R, Balass M, Scherf T, Harel M, Fridkin M, Sussman JL, Fuchs S. Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity and mimic the three-dimensional structure of the binding-site of acetylcholine receptor. Biophysical Chemistry. 100: 293-305. PMID 12646372 DOI: 10.1016/S0301-4622(02)00287-9  1
2003 Zeev-Ben-Mordehai T, Silman I, Sussman JL. Acetylcholinesterase in motion: Visualizing conformational changes in crystal structures by a morphing procedure Biopolymers. 68: 395-406. PMID 12601798 DOI: 10.1002/bip.10287  1
2003 Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. Journal of the American Chemical Society. 125: 363-73. PMID 12517147 DOI: 10.1021/ja021111w  1
2002 Weik M, Bergès J, Raves ML, Gros P, McSweeney S, Silman I, Sussman JL, Houée-Levin C, Ravelli RB. Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation. Journal of Synchrotron Radiation. 9: 342-6. PMID 12409620 DOI: 10.1107/S0909049502014589  1
2002 Felder CE, Harel M, Silman I, Sussman JL. Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase. Acta Crystallographica. Section D, Biological Crystallography. 58: 1765-71. PMID 12351819 DOI: 10.1107/S0907444902011642  1
2002 Dvir H, Jiang HL, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL. X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. Biochemistry. 41: 10810-8. PMID 12196020 DOI: 10.1021/bi020151+  1
2002 Koellner G, Steiner T, Millard CB, Silman I, Sussman JL. A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica. Journal of Molecular Biology. 320: 721-5. PMID 12095250 DOI: 10.1016/S0022-2836(02)00475-8  1
2002 Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I. Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine Biochemistry. 41: 3555-3564. PMID 11888271 DOI: 10.1021/bi020016x  1
2002 Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Muñoz-Torrero D, Camps P, Rosenberry TL, Silman I, Sussman JL. 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates. Biochemistry. 41: 2970-81. PMID 11863435 DOI: 10.1021/bi011652i  1
2002 Liu T, Sussman JL, Gu J, Tan XJ, Zhu WL, Luo XM, Jiang HL, Ji RY, Chen KX, Silman I. The relationship between binding models of TMA with furan and imidazole and the molecular electrostatic potentials: DFT and MP2 computational studies Journal of Physical Chemistry A. 106: 157-164. DOI: 10.1021/jp0113275  1
2001 Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 32: 265-75. PMID 11683996 DOI: 10.1016/S0896-6273(01)00461-5  1
2001 Weik M, Ravelli RB, Silman I, Sussman JL, Gros P, Kroon J. Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes. Protein Science : a Publication of the Protein Society. 10: 1953-61. PMID 11567086 DOI: 10.1110/ps.09801  1
2001 Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J, Viner R, Silman I, Sussman JL, Greenblatt HM, Lewis T. A structure-based design approach to the development of novel, reversible AChE inhibitors Journal of Medicinal Chemistry. 44: 3203-3215. PMID 11563919 DOI: 10.1021/jm010826r  1
2001 Nicolas A, Ferron F, Toker L, Sussman JL, Silman I. Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase. Acta Crystallographica. Section D, Biological Crystallography. 57: 1348-50. PMID 11526341 DOI: 10.1107/S0907444901010411  0.48
2001 Weik M, Kryger G, Schreurs AM, Bouma B, Silman I, Sussman JL, Gros P, Kroon J. Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures. Acta Crystallographica. Section D, Biological Crystallography. 57: 566-73. PMID 11264586 DOI: 10.1107/S0907444901001196  1
2001 Jian Tan X, Liang Zhu W, Cui M, Min Luo X, De Gu J, Silman I, Sussman JL, Liang Jiang H, Yun Ji R, Xian Chen K. Noncovalent interaction or chemical bonding between alkaline earth cations and benzene? a quantum chemistry study using MP2 and density-functional theory methods Chemical Physics Letters. 349: 113-122. DOI: 10.1016/S0009-2614(01)01176-9  1
2001 Liu T, Gu J, Tan XJ, Zhu WL, Luo XM, Jiang HL, Ji RY, Chen KX, Silman I, Sussman JL. Theoretical insight into the interactions of TMA-benzene and TMA-pyrrole with B3LYP Density-Functional Theory (DFT) and ab initio second order Møller-Plesset perturbation theory (MP2) calculations Journal of Physical Chemistry A. 105: 5431-5437.  1
2001 Felder C, Jiang HL, Zhu WL, Chen KX, Silman I, Bottijt SA, Sussman JL. Quantum/classical mechanical comparison of cation-π interactions between tetramethylammonium and benzene Journal of Physical Chemistry A. 105: 1326-1333.  1
2000 Lamzin VS, Perrakis A, Bricogne G, Jiang J, Swaminathan S, Sussman JL. Apotheosis, not apocalypse: methods in protein crystallography. Acta Crystallographica. Section D, Biological Crystallography. 56: 1510-1. PMID 11053868 DOI: 10.1107/S0907444900010751  1
2000 Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL. Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II Acta Crystallographica Section D: Biological Crystallography. 56: 1385-1394. PMID 11053835 DOI: 10.1107/S0907444900010659  0.48
2000 Lin D, Manning NO, Jiang J, Abola EE, Stampf D, Prilusky J, Sussman JL. AutoDep: A web-based system for deposition and validation of macromolecular structural Acta Crystallographica Section D: Biological Crystallography. 56: 828-841. PMID 10930830 DOI: 10.1107/S0907444900005655  1
2000 Harel M, Kryger G, Rosenberry TL, Mallender WD, Lewis T, Fletcher RJ, Guss JM, Silman I, Sussman JL. Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors Protein Science. 9: 1063-1072. PMID 10892800  1
2000 Kraut D, Goff H, Pai RK, Hosea NA, Silman I, Sussman JL, Taylor P, Voet JG. Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride. Molecular Pharmacology. 57: 1243-8. PMID 10825396  1
2000 Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, Steiner T. Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica Journal of Molecular Biology. 296: 713-735. PMID 10669619 DOI: 10.1006/jmbi.1999.3468  1
2000 Weik M, Ravelli RBG, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL. Specific chemical and structural damage to proteins produced by synchrotron radiation Proceedings of the National Academy of Sciences of the United States of America. 97: 623-628. PMID 10639129 DOI: 10.1073/pnas.97.2.623  1
2000 Zhu WL, Tan XJ, Puah CM, Gu JD, Jiang HL, Chen KX, Felder CE, Silman I, Sussman JL. How does ammonium interact with aromatic groups? A density functional theory (DFT/B3LYP) investigation Journal of Physical Chemistry A. 104: 9573-9580. DOI: 10.1021/jp001306v  1
2000 Greenblatt HM, Silman I, Sussman JL. Structural studies on vertebrate and invertebrate acetylcholinesterases and their complexes with functional ligands Drug Development Research. 50: 573-583.  1
1999 Sussman JL, Abola EE, Lin D, Jiang J, Manning NO, Prilusky J. The protein data bank: Bridging the gap between the sequence and 3D structure world Genetica. 106: 149-158. PMID 10710721  1
1999 Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 Å resolution Febs Letters. 463: 321-326. PMID 10606746 DOI: 10.1016/S0014-5793(99)01637-3  1
1999 Botti SA, Felder CE, Lifson S, Sussman JL, Silman I. A modular treatment of molecular traffic through the active site of cholinesterase. Biophysical Journal. 77: 2430-50. PMID 10545346  1
1999 Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL. A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase Chemico-Biological Interactions. 119: 43-52. PMID 10421437 DOI: 10.1016/S0009-2797(99)00012-5  1
1999 Kryger G, Silman I, Sussman JL. Structure of acetylcholinesterase complexed with E2020 (Ariceptρ): Implications for the design of new anti-Alzheimer drugs Structure. 7: 297-307. PMID 10368299 DOI: 10.1016/S0969-2126(99)80040-9  1
1999 Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL. Crystal structures of aged phosphonylated acetylcholinesterase: Nerve agent reaction products at the atomic level Biochemistry. 38: 7032-7039. PMID 10353814 DOI: 10.1021/bi982678l  1
1999 Morel N, Bon S, Greenblatt HM, Van Belle D, Wodak SJ, Sussman JL, Massoulié J, Silman I. Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase. Molecular Pharmacology. 55: 982-92. PMID 10347238  1
1999 Jiang J, Abola E, Sussman JL. Deposition of structure factors at the Protein Data Bank [2] Acta Crystallographica Section D: Biological Crystallography. 55: 4. PMID 10089388  1
1999 Millard CB, Koellner G, Ordentlich A, Shafferman A, Silman I, Sussman JL. Reaction products of acetylcholinesterase and VX reveal a mobile histidine in the catalytic triad [7] Journal of the American Chemical Society. 121: 9883-9884. DOI: 10.1021/ja992704i  1
1998 Ravelli RBG, Raves ML, Ren Z, Bourgeois D, Roth M, Kroon J, Silman I, Sussman JL. Static Laue diffraction studies on acetylcholinesterase Acta Crystallographica Section D: Biological Crystallography. 54: 1359-1366. PMID 10089512 DOI: 10.1107/S0907444998005277  1
1998 Sussman JL, Lin D, Jiang J, Manning NO, Prilusky J, Ritter O, Abola EE. Protein Data Bank (PDB): Database of three-dimensional structural information of biological macromolecules Acta Crystallographica Section D: Biological Crystallography. 54: 1078-1084. PMID 10089483 DOI: 10.1107/S0907444998009378  1
1998 Sussman JL. Protein data bank deposits [5] Science. 282: 1993. PMID 9874649 DOI: 10.1126/science.282.5396.1991f  1
1998 Kryger G, Silman I, Sussman JL. Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica Journal of Physiology Paris. 92: 191-194. PMID 9789806 DOI: 10.1016/S0928-4257(98)80008-9  1
1998 Botti SA, Felder CE, Sussman JL, Silman I. Electrotactins: A class of adhesion proteins with conserved electrostatic and structural motifs Protein Engineering. 11: 415-420. PMID 9725619  1
1998 Wlodawer A, Davies D, Petsko G, Rossmann M, Olson A, Sussman JL. Immediate release of crystallographic data: A proposal [3] Science. 279: 306-307. PMID 9454319  1
1997 Felder CE, Botti SA, Lifson S, Silman I, Sussman JL. External and internal electrostatic potentials of cholinesterase models. Journal of Molecular Graphics & Modelling. 15: 318-27, 335-7. PMID 9640563 DOI: 10.1016/S1093-3263(98)00005-9  1
1997 Abola EE, Sussman JL, Prilusky J, Manning NO. Protein data bank archives of three-dimensional macromolecular structures Methods in Enzymology. 277: 556-571. PMID 9379928 DOI: 10.1016/S0076-6879(97)77031-9  1
1997 Sussman JL. Bridging the gap Nature Structural Biology. 4: 517. PMID 9228940  1
1997 Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A Nature Structural Biology. 4: 57-63. PMID 8989325 DOI: 10.1038/nsb0197-57  1
1996 Abola EE, Manning NO, Prilusky J, Stampf DR, Sussman JL. The Protein Data Bank: Current Status and Future Challenges. Journal of Research of the National Institute of Standards and Technology. 101: 231-241. PMID 27805161 DOI: 10.6028/jres.101.025  0.64
1996 Marchot P, Ravelli RBG, Raves ML, Bourne Y, Vellom DC, Kanter J, Camp S, Sussman JL, Taylor P. Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin Protein Science. 5: 672-679. PMID 8845756  1
1996 Wlodek ST, Antosiewicz J, McCammon JA, Straatsma TP, Gilson MK, Briggs JM, Humblet C, Sussman JL. Binding of tacrine and 6-chlorotacrine by acetylcholinesterase. Biopolymers. 38: 109-17. PMID 8679940 DOI: 10.1002/(SICI)1097-0282(199601)38:1<109::AID-BIP9>3.0.CO;2-#  1
1996 Faerman C, Ripoll D, Bon S, Le Feuvre Y, Morel N, Massoulié J, Sussman JL, Silman I. Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function. Febs Letters. 386: 65-71. PMID 8635606 DOI: 10.1016/0014-5793(96)00374-2  1
1996 Frolow F, Harel M, Sussman JL, Mevarech M, Shoham M. Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin. Nature Structural Biology. 3: 452-8. PMID 8612076 DOI: 10.1038/nsb0596-452  1
1996 Harel M, Quinn DM, Nair HK, Silman I, Sussman JL. The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase Journal of the American Chemical Society. 118: 2340-2346. DOI: 10.1021/ja952232h  1
1995 Sussman JL, Berman HM. New guidelines for deposition of nucleic acid structures Structure. 3: 1426. PMID 8747467  1
1995 Harel M, Kleywegt GJ, Ravelli RB, Silman I, Sussman JL. Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. Structure (London, England : 1993). 3: 1355-66. PMID 8747462 DOI: 10.1016/S0969-2126(01)00273-8  1
1995 Peitsch MC, Wells TNC, Stampf DR, Sussman JL. The Swiss-3DImage collection and PDB-Browser on the World-Wide Web Trends in Biochemical Sciences. 20: 82-84. PMID 7701568 DOI: 10.1016/S0968-0004(00)88963-X  1
1995 Stampf DR, Felder CE, Sussman JL. PDBbrowse--a graphics interface to the Brookhaven Protein Data Bank Nature. 374: 572-574. PMID 7700388  1
1995 Alon RN, Mirny L, Sussman JL, Gutnick DL. Detection of α/β-hydrolase fold in the cell surface esterases of Acinetobacter species using an analysis of 3D profiles Febs Letters. 371: 231-235. PMID 7556598 DOI: 10.1016/0014-5793(95)00861-3  1
1995 Dym O, Mevarech M, Sussman JL. Structural features that stabilize halophilic malate dehydrogenase from an archaebacterium Science. 267: 1344-1346.  1
1994 Gilson MK, Straatsma TP, McCammon JA, Ripoll DR, Faerman CH, Axelsen PH, Silman I, Sussman JL. Open 'back door' in a molecular dynamics simulation of acetylcholinesterase Science. 263: 1276-1278. PMID 8122110  1
1994 Eichler J, Anselment A, Sussman JL, Massoulié J, Silman I. Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase. Molecular Pharmacology. 45: 335-40. PMID 8114681  1
1994 Axelsen PH, Harel M, Silman I, Sussman JL. Structure and dynamics of the active site gorge of acetylcholinesterase: Synergistic use of molecular dynamics simulation and X-ray crystallography Protein Science. 3: 188-197. PMID 8003956  1
1994 Silman I, Harel M, Axelsen P, Raves M, Sussman JL. Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents Biochemical Society Transactions. 22: 745-749. PMID 7821677  1
1993 Reich Z, Friedman P, Scolnik Y, Sussman JL, Minsky A. On the metastability of left-handed DNA motifs Biochemistry. 32: 2116-2119. PMID 8448169  1
1993 Tan RC, Truong TN, McCammon JA, Sussman JL. Acetylcholinesterase: electrostatic steering increases the rate of ligand binding. Biochemistry. 32: 401-3. PMID 8422348  1
1993 Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proceedings of the National Academy of Sciences of the United States of America. 90: 9031-5. PMID 8415649 DOI: 10.1073/pnas.90.19.9031  1
1993 Livnah O, Bayer EA, Wilchek M, Sussman JL. The structure of the complex between avidin and the dye, 2-(4'-hydroxyazobenzene) benzoic acid (HABA) Febs Letters. 328: 165-168. PMID 8344421 DOI: 10.1016/0014-5793(93)80986-5  1
1993 Sussman JL, Harel M, Silman I. Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs Chemico-Biological Interactions. 87: 187-197. PMID 8343975 DOI: 10.1016/0009-2797(93)90042-W  1
1993 Unger R, Sussman JL. The importance of short structural motifs in protein structure analysis Journal of Computer-Aided Molecular Design. 7: 457-472. PMID 8229095 DOI: 10.1007/BF02337561  1
1981 Holbrook SR, Sussman JL, Kim SH. Absence of correlation between base-pair sequence and RNA conformation. Science (New York, N.Y.). 212: 1275-7. PMID 6165084  1
1978 Holbrook SR, Sussman JL, Warrant RW, Kim SH. Crystal structure of yeast phenylalanine transfer RNA. II. Structural features and functional implications. Journal of Molecular Biology. 123: 631-60. PMID 357743  1
1978 Sussman JL, Holbrook SR, Warrant RW, Church GM, Kim SH. Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement. Journal of Molecular Biology. 123: 607-30. PMID 357742  1
1977 Kim SH, Sussman JL. Transfer RNA: structure-function correlation. Horizons in Biochemistry and Biophysics. 4: 159-200. PMID 563842  1
1977 Holbrook SR, Sussman JL, Warrant RW, Church GM, Kim SH. RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe. Nucleic Acids Research. 4: 2811-20. PMID 333395  1
1977 Church GM, Sussman JL, Kim SH. Secondary structural complementarity between DNA and proteins. Proceedings of the National Academy of Sciences of the United States of America. 74: 1458-62. PMID 266187  1
1976 Sussman JL, Kim SH. Idealized atomic coordinates of yeast phenylalanine transfer RNA. Biochemical and Biophysical Research Communications. 68: 89-96. PMID 1108880  1
1976 Kim SH, Sussman JL. pi turn is a conformational pattern in RNA loops and bends. Nature. 260: 645-6. PMID 772447  1
1975 Quigley GJ, Wang AH, Seeman NC, Suddath FL, Rich A, Sussman JL, Kim SH. Hydrogen bonding in yeast phenylalanine transfer RNA. Proceedings of the National Academy of Sciences of the United States of America. 72: 4866-70. PMID 1108007  1
1974 Kim SH, Sussman JL, Suddath FL, Quigley GJ, McPherson A, Wang AH, Seeman NC, RICH A. The general structure of transfer RNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 71: 4970-4. PMID 4612535  1
1974 Kim SH, Suddath FL, Quigley GJ, McPherson A, Sussman JL, Wang AH, Seeman NC, Rich A. Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science (New York, N.Y.). 185: 435-40. PMID 4601792  1
1972 Sussman JL, Seeman NC, Kim SH, Berman HM. Crystal structure of a naturally occurring dinucleoside phoaphate: uridylyl 3',5'-adenosine phosphate model for RNA chain folding. Journal of Molecular Biology. 66: 403-21. PMID 5037021  1
1971 Seeman NC, Sussman JL, Berman HN, Kim SH. Nucleic acid conformation: crystal structure of a naturally occurring dinucleoside phosphate (UpA). Nature: New Biology. 233: 90-2. PMID 5287004  1
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