| Year |
Citation |
Score |
| 2023 |
Shamir M, Martin FJO, Woolfson DN, Friedler A. Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization. International Journal of Molecular Sciences. 24. PMID 37834064 DOI: 10.3390/ijms241914616 |
0.357 |
|
| 2023 |
Garfagnini T, Bemporad F, Harries D, Chiti F, Friedler A. Amyloid Aggregation Is Potently Slowed Down by Osmolytes Due to Compaction of Partially Folded State. Journal of Molecular Biology. 435: 168281. PMID 37734431 DOI: 10.1016/j.jmb.2023.168281 |
0.52 |
|
| 2022 |
Grunhaus D, Molina ER, Cohen R, Stein T, Friedler A, Hurevich M. Accelerated Multiphosphorylated Peptide Synthesis. Organic Process Research & Development. 26: 2492-2497. PMID 36032360 DOI: 10.1021/acs.oprd.2c00164 |
0.306 |
|
| 2022 |
Mayer G, Shpilt Z, Kowalski H, Tshuva EY, Friedler A. Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors. Acs Chemical Biology. PMID 35758642 DOI: 10.1021/acschembio.2c00177 |
0.356 |
|
| 2022 |
Joshi PN, Mervinetsky E, Solomon O, Chen YJ, Yitzchaik S, Friedler A. Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site. Biosensors & Bioelectronics. 207: 114177. PMID 35305389 DOI: 10.1016/j.bios.2022.114177 |
0.707 |
|
| 2021 |
Garfagnini T, Levi-Kalisman Y, Harries D, Friedler A. Osmolytes and crowders regulate aggregation of the cancer-related L106R mutant of the Axin protein. Biophysical Journal. PMID 34087214 DOI: 10.1016/j.bpj.2021.05.024 |
0.511 |
|
| 2020 |
Samarasimhareddy M, Shamir M, Shalev DE, Hurevich M, Friedler A. A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids. Frontiers in Chemistry. 8: 405. PMID 32509731 DOI: 10.3389/Fchem.2020.00405 |
0.463 |
|
| 2020 |
Samarasimhareddy M, Mayer G, Hurevich M, Friedler A. Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms. Organic & Biomolecular Chemistry. PMID 32322853 DOI: 10.1039/D0Ob00499E |
0.426 |
|
| 2020 |
Lahav N, Rotem-Bamberger S, Fahoum J, Dodson EJ, Kraus Y, Mousa R, Metanis N, Friedler A, Schueler-Furman O. Phosphorylation of the WWOX protein regulates its interaction with p73. Chembiochem : a European Journal of Chemical Biology. PMID 32185845 DOI: 10.1002/Cbic.202000032 |
0.414 |
|
| 2020 |
Mayer G, Shpilt Z, Bressler S, Marcu O, Schueler-Furman O, Tshuva EY, Friedler A. Targeting an interaction between two disordered domains using a designed peptide. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32181542 DOI: 10.1002/Chem.202000465 |
0.499 |
|
| 2020 |
Mayer G, Shpilt Z, Bressler S, Marcu O, Schueler‐Furman O, Tshuva EY, Friedler A. Front Cover: Targeting an Interaction Between Two Disordered Domains by Using a Designed Peptide (Chem. Eur. J. 45/2020) Chemistry: a European Journal. 26: 10152-10152. DOI: 10.1002/Chem.202002213 |
0.39 |
|
| 2019 |
Rimon A, Mondal R, Friedler A, Padan E. Cardiolipin is an Optimal Phospholipid for the Assembly, Stability, and Proper Functionality of the Dimeric Form of NhaA Na/H Antiporter. Scientific Reports. 9: 17662. PMID 31776461 DOI: 10.1038/S41598-019-54198-8 |
0.331 |
|
| 2019 |
Samarasimhareddy M, Mayer D, Metanis N, Veprintsev D, Hurevich M, Friedler A. A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins. Organic & Biomolecular Chemistry. PMID 31497840 DOI: 10.1039/C9Ob01874C |
0.399 |
|
| 2019 |
Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, ... Friedler A, et al. Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Nature Communications. 10: 1261. PMID 30890705 DOI: 10.1038/S41467-019-09204-Y |
0.399 |
|
| 2019 |
Iosub-Amir A, Bai F, Sohn YS, Song L, Tamir S, Marjault HB, Mayer G, Karmi O, Jennings PA, Mittler R, Onuchic JN, Friedler A, Nechushtai R. The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells. Chemical Science. 10: 665-673. PMID 30774867 DOI: 10.1039/C8Sc03390K |
0.363 |
|
| 2018 |
Faust O, Grunhaus D, Shimshon O, Yavin E, Friedler A. Protein Regulation by Intrinsically Disordered Regions: A Role for Subdomains in the IDR of the HIV-1 Rev Protein. Chembiochem : a European Journal of Chemical Biology. 19: 1618-1624. PMID 29791766 DOI: 10.1002/Cbic.201800192 |
0.371 |
|
| 2018 |
Amartely H, Avraham O, Friedler A, Livnah O, Lebendiker M. Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization. Scientific Reports. 8: 6907. PMID 29720692 DOI: 10.1038/S41598-018-25246-6 |
0.333 |
|
| 2018 |
Katz C, Low-Calle AM, Choe J, Laptenko O, Tong D, Joseph-Chowdhury JN, Garofalo F, Zhu Y, Friedler A, Prives C. Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers. Genes & Development. PMID 29549180 DOI: 10.1101/Gad.304071.117 |
0.355 |
|
| 2018 |
Rimon A, Dwivedi M, Friedler A, Padan E. Asp133 Residue in NhaA Na/H Antiporter Is Required for Stability Cation Binding and Transport. Journal of Molecular Biology. 430: 867-880. PMID 29410365 DOI: 10.1016/J.Jmb.2018.01.014 |
0.301 |
|
| 2017 |
Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, Friedler A, Strömqvist J, Wennmalm S, Carlsson J, Schulte G. Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling. Nature Communications. 8: 226. PMID 28790300 DOI: 10.1038/S41467-017-00253-9 |
0.306 |
|
| 2017 |
Chandra K, Das P, Metanis N, Friedler A, Reches M. Peptide fibrils as monomer storage of the covalent HIV-1 integrase inhibitor. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 28070909 DOI: 10.1002/Psc.2959 |
0.497 |
|
| 2016 |
Amartely H, David A, Shamir M, Lebendiker M, Izraeli S, Friedler A. Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein. Chemical Science. 7: 4140-4147. PMID 30155058 DOI: 10.1039/C6Sc00115G |
0.338 |
|
| 2016 |
Zhuravel R, Amit E, Elbaz S, Rotem D, Chen YJ, Friedler A, Yitzchaik S, Porath D. Atomic force microscopy characterization of kinase-mediated phosphorylation of a peptide monolayer. Scientific Reports. 6: 36793. PMID 27841355 DOI: 10.1038/Srep36793 |
0.381 |
|
| 2016 |
Postel S, Deredge D, Bonsor DA, Yu X, Diederichs K, Helmsing S, Vromen A, Friedler A, Hust M, Egelman EH, Beckett D, Wintrode PL, Sundberg EJ. Bacterial flagellar capping proteins adopt diverse oligomeric states. Elife. 5. PMID 27664419 DOI: 10.7554/Elife.18857 |
0.32 |
|
| 2016 |
Chandra K, Das P, Mamidi S, Hurevich M, Iosub-Amir A, Metanis N, Reches M, Friedler A. Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides. Chemmedchem. PMID 27331774 DOI: 10.1002/Cmdc.201600190 |
0.522 |
|
| 2016 |
David A, Amartely H, Rabinowicz N, Shamir M, Friedler A, Izraeli S. Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells. Scientific Reports. 6: 24296. PMID 27075531 DOI: 10.1038/Srep24296 |
0.434 |
|
| 2016 |
Chandra K, Das P, Mamidi S, Hurevich M, Iosub-Amir A, Metanis N, Reches M, Friedler A. Cover Picture: Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides (ChemMedChem 18/2016) Chemmedchem. 11: 1969. DOI: 10.1002/Cmdc.201600435 |
0.434 |
|
| 2015 |
Amir AI, van Rosmalen M, Mayer G, Lebendiker M, Danieli T, Friedler A. Highly homologous proteins exert opposite biological activities by using different interaction interfaces. Scientific Reports. 5: 11629. PMID 26130271 DOI: 10.1038/Srep11629 |
0.383 |
|
| 2015 |
Chandra K, Maes M, Friedler A. Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides. Future Medicinal Chemistry. 7: 1055-77. PMID 26062401 DOI: 10.4155/Fmc.15.46 |
0.442 |
|
| 2015 |
Reingewertz TH, Iosub-Amir A, Bonsor DA, Mayer G, Amartely H, Friedler A, Sundberg EJ. An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA. Biochemistry. 54: 3337-47. PMID 25963096 DOI: 10.1021/Acs.Biochem.5B00084 |
0.415 |
|
| 2015 |
Snir E, Amit E, Friedler A, Yitzchaik S. A highly sensitive square wave voltammetry based biosensor for kinase activity measurements. Biopolymers. 104: 515-20. PMID 25851749 DOI: 10.1002/Bip.22653 |
0.335 |
|
| 2015 |
Chandra K, Naoum JN, Roy TK, Gilon C, Gerber RB, Friedler A. Mechanistic studies of malonic acid-mediated in situ acylation. Biopolymers. 104: 495-505. PMID 25846609 DOI: 10.1002/Bip.22654 |
0.566 |
|
| 2015 |
Lebendiker M, Maes M, Friedler A. A screening methodology for purifying proteins with aggregation problems. Methods in Molecular Biology (Clifton, N.J.). 1258: 261-81. PMID 25447869 DOI: 10.1007/978-1-4939-2205-5_14 |
0.327 |
|
| 2014 |
Amartely H, Iosub-Amir A, Friedler A. Identifying protein-protein interaction sites using peptide arrays. Journal of Visualized Experiments : Jove. e52097. PMID 25490271 DOI: 10.3791/52097 |
0.493 |
|
| 2014 |
Maes M, Amit E, Danieli T, Lebendiker M, Loyter A, Friedler A, Schreiber G. The disordered region of arabidopsis VIP1 binds the agrobacterium VirE2 protein outside its DNA-binding site Protein Engineering, Design and Selection. 27: 439-446. PMID 25212215 DOI: 10.1093/Protein/Gzu036 |
0.417 |
|
| 2014 |
Faust O, Bigman L, Friedler A. A role of disordered domains in regulating protein oligomerization and stability. Chemical Communications (Cambridge, England). 50: 10797-800. PMID 25054624 DOI: 10.1039/C4Cc03863K |
0.341 |
|
| 2014 |
Chandra K, Roy TK, Shalev DE, Loyter A, Gilon C, Gerber RB, Friedler A. A tandem in situ peptide cyclization through trifluoroacetic acid cleavage. Angewandte Chemie (International Ed. in English). 53: 9450-5. PMID 24827640 DOI: 10.1002/Anie.201402789 |
0.625 |
|
| 2014 |
Gabizon R, Friedler A. Allosteric modulation of protein oligomerization: an emerging approach to drug design. Frontiers in Chemistry. 2: 9. PMID 24790978 DOI: 10.3389/Fchem.2014.00009 |
0.39 |
|
| 2014 |
Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R. Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proceedings of the National Academy of Sciences of the United States of America. 111: 5177-82. PMID 24706857 DOI: 10.1073/Pnas.1403770111 |
0.417 |
|
| 2014 |
Zeytuni N, Uebe R, Maes M, Davidov G, Baram M, Raschdorf O, Nadav-Tsubery M, Kolusheva S, Bitton R, Goobes G, Friedler A, Miller Y, Schüler D, Zarivach R. Cation diffusion facilitators transport initiation and regulation is mediated by cation induced conformational changes of the cytoplasmic domain. Plos One. 9: e92141. PMID 24658343 DOI: 10.1371/Journal.Pone.0092141 |
0.331 |
|
| 2014 |
Chandra K, Roy TK, Naoum JN, Gilon C, Gerber RB, Friedler A. A highly efficient in situ N-acetylation approach for solid phase synthesis. Organic & Biomolecular Chemistry. 12: 1879-84. PMID 24526269 DOI: 10.1039/C3Ob42096E |
0.569 |
|
| 2014 |
Amartely H, David A, Lebendiker M, Benyamini H, Izraeli S, Friedler A. The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions. Chemical Communications (Cambridge, England). 50: 5245-7. PMID 24022511 DOI: 10.1039/C3Cc45096A |
0.347 |
|
| 2014 |
Chandra K, Roy TK, Shalev DE, Loyter A, Gilon C, Gerber RB, Friedler A. Frontispiece: A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage Angewandte Chemie International Edition. 53: n/a-n/a. DOI: 10.1002/Anie.201483671 |
0.608 |
|
| 2013 |
Shahar OD, Gabizon R, Feine O, Alhadeff R, Ganoth A, Argaman L, Shimshoni E, Friedler A, Goldberg M. Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro Plos One. 8. PMID 24194938 DOI: 10.1371/Journal.Pone.0078472 |
0.331 |
|
| 2013 |
Bonsor DA, Weiss E, Iosub-Amir A, Reingewertz TH, Chen TW, Haas R, Friedler A, Fischer W, Sundberg EJ. Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF. The Journal of Biological Chemistry. 288: 32897-909. PMID 24072713 DOI: 10.1074/Jbc.M113.507657 |
0.385 |
|
| 2013 |
Reingewertz TH, Britan-Rosich E, Rotem-Bamberger S, Viard M, Jacobs A, Miller A, Lee JY, Hwang J, Blumenthal R, Kotler M, Friedler A. Mapping the Vif-A3G interaction using peptide arrays: a basis for anti-HIV lead peptides. Bioorganic & Medicinal Chemistry. 21: 3523-32. PMID 23545135 DOI: 10.1016/J.Bmc.2013.03.001 |
0.432 |
|
| 2013 |
Rotem-Bamberger S, Katz C, Friedler A. Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism. Plos One. 8: e58470. PMID 23472201 DOI: 10.1371/Journal.Pone.0058470 |
0.438 |
|
| 2013 |
Guy S, Rotem D, Hayouka Z, Gabizon R, Levin A, Zemel L, Loyter A, Porath D, Friedler A. Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system. Chemical Communications (Cambridge, England). 49: 3113-5. PMID 23463374 DOI: 10.1039/C3Cc40748A |
0.31 |
|
| 2013 |
Rosenberg MM, Ronen D, Lahav N, Nazirov E, Ravid S, Friedler A. High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly. The Journal of Biological Chemistry. 288: 9779-89. PMID 23426373 DOI: 10.1074/Jbc.M112.430173 |
0.367 |
|
| 2013 |
Gabizon R, Faust O, Benyamini H, Nir S, Loyter A, Friedler A. Structure–activity relationship studies using peptide arrays: the example of HIV-1 Rev–integrase interaction Medchemcomm. 4: 252-259. DOI: 10.1039/C2Md20225E |
0.44 |
|
| 2012 |
Maes M, Loyter A, Friedler A. Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions. The Febs Journal. 279: 2795-809. PMID 22742518 DOI: 10.1111/J.1742-4658.2012.08680.X |
0.481 |
|
| 2012 |
Gabizon R, Brandt T, Sukenik S, Lahav N, Lebendiker M, Shalev DE, Veprintsev D, Friedler A. Specific recognition of p53 tetramers by peptides derived from p53 interacting proteins. Plos One. 7: e38060. PMID 22693587 DOI: 10.1371/Journal.Pone.0038060 |
0.519 |
|
| 2012 |
Hayouka Z, Levin A, Hurevich M, Shalev DE, Loyter A, Gilon C, Friedler A. A comparative study of backbone versus side chain peptide cyclization: application for HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 20: 3317-22. PMID 22507205 DOI: 10.1016/J.Bmc.2012.03.039 |
0.653 |
|
| 2012 |
Katz C, Zaltsman-Amir Y, Mostizky Y, Kollet N, Gross A, Friedler A. Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. The Journal of Biological Chemistry. 287: 15016-23. PMID 22416135 DOI: 10.1074/Jbc.M111.328377 |
0.455 |
|
| 2012 |
Edison N, Reingewertz TH, Gottfried Y, Lev T, Zuri D, Maniv I, Carp MJ, Shalev G, Friedler A, Larisch S. Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 2569-78. PMID 22392914 DOI: 10.1158/1078-0432.Ccr-11-1430 |
0.434 |
|
| 2012 |
Conlan AR, Zuris JA, Paddock ML, Katz C, Tamir S, Rotem-Bamberger S, Friedler A, Nechushtai R, Jennings PA. The Interaction Between Cisd2 and Bcl Proteins at a Non-BH3 Domain Binding Site Biophysical Journal. 102: 258a-259a. DOI: 10.1016/J.Bpj.2011.11.1425 |
0.374 |
|
| 2011 |
Benyamini H, Loyter A, Friedler A. A structural model of the HIV-1 Rev-integrase complex: the molecular basis of integrase regulation by Rev. Biochemical and Biophysical Research Communications. 416: 252-7. PMID 22093836 DOI: 10.1016/J.Bbrc.2011.10.116 |
0.495 |
|
| 2011 |
Furth N, Gertman O, Shiber A, Alfassy OS, Cohen I, Rosenberg MM, Doron NK, Friedler A, Ravid T. Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope. Molecular Biology of the Cell. 22: 4726-39. PMID 21998200 DOI: 10.1091/Mbc.E11-05-0463 |
0.346 |
|
| 2011 |
Reingewertz TH, Shalev DE, Sukenik S, Blatt O, Rotem-Bamberger S, Lebendiker M, Larisch S, Friedler A. Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP. Plos One. 6: e24655. PMID 21949740 DOI: 10.1371/Journal.Pone.0024655 |
0.41 |
|
| 2011 |
Siman P, Blatt O, Moyal T, Danieli T, Lebendiker M, Lashuel HA, Friedler A, Brik A. Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European Journal of Chemical Biology. 12: 1097-104. PMID 21488138 DOI: 10.1002/Cbic.201100033 |
0.371 |
|
| 2011 |
Flashner E, Raviv U, Friedler A. The effect of tachykinin neuropeptides on amyloid β aggregation. Biochemical and Biophysical Research Communications. 407: 13-7. PMID 21352807 DOI: 10.1016/J.Bbrc.2011.02.067 |
0.339 |
|
| 2011 |
Sukenik S, Politi R, Ziserman L, Danino D, Friedler A, Harries D. Crowding alone cannot account for cosolute effect on amyloid aggregation. Plos One. 6: e15608. PMID 21249221 DOI: 10.1016/J.Bpj.2010.12.1311 |
0.606 |
|
| 2011 |
Katz C, Levy-Beladev L, Rotem-Bamberger S, Rito T, Rüdiger SG, Friedler A. Studying protein-protein interactions using peptide arrays. Chemical Society Reviews. 40: 2131-45. PMID 21243154 DOI: 10.1039/C0Cs00029A |
0.495 |
|
| 2011 |
Levin A, Benyamini H, Hayouka Z, Friedler A, Loyter A. Peptides that bind the HIV-1 integrase and modulate its enzymatic activity--kinetic studies and mode of action. The Febs Journal. 278: 316-30. PMID 21156026 DOI: 10.1111/J.1742-4658.2010.07952.X |
0.492 |
|
| 2011 |
Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM. Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded. Journal of Molecular Biology. 405: 773-86. PMID 21087614 DOI: 10.1016/J.Jmb.2010.11.013 |
0.316 |
|
| 2011 |
Friedler A. From peptides to proteins: lessons from my years at the Centre for Protein Engineering. Protein Engineering, Design & Selection : Peds. 24: 241-5. PMID 21062759 DOI: 10.1093/Protein/Gzq080 |
0.374 |
|
| 2011 |
Benyamini H, Friedler A. The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteins. Journal of Molecular Recognition : Jmr. 24: 266-74. PMID 20623514 DOI: 10.1002/Jmr.1048 |
0.387 |
|
| 2010 |
Benyamini H, Friedler A. Using peptides to study protein-protein interactions. Future Medicinal Chemistry. 2: 989-1003. PMID 21426115 DOI: 10.4155/Fmc.10.196 |
0.452 |
|
| 2010 |
Levin A, Hayouka Z, Friedler A, Loyter A. Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein. Nucleus (Austin, Tex.). 1: 190-201. PMID 21326951 DOI: 10.4161/Nucl.1.2.11300 |
0.415 |
|
| 2010 |
Levin A, Hayouka Z, Friedler A, Loyter A. Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus (Austin, Tex.). 1: 422-31. PMID 21326825 DOI: 10.4161/Nucl.1.5.12903 |
0.37 |
|
| 2010 |
Hayouka Z, Hurevich M, Levin A, Benyamini H, Iosub A, Maes M, Shalev DE, Loyter A, Gilon C, Friedler A. Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein. Bioorganic & Medicinal Chemistry. 18: 8388-95. PMID 20974536 DOI: 10.1016/J.Bmc.2010.09.046 |
0.673 |
|
| 2010 |
Levy-Beladev L, Levdansky L, Gaberman E, Friedler A, Gorodetsky R. A family of cell-adhering peptides homologous to fibrinogen C-termini. Biochemical and Biophysical Research Communications. 401: 124-30. PMID 20833137 DOI: 10.1016/J.Bbrc.2010.09.024 |
0.425 |
|
| 2010 |
Levin A, Hayouka Z, Friedler A, Loyter A. Specific eradication of HIV-1 from infected cultured cells. Aids Research and Therapy. 7: 31. PMID 20723214 DOI: 10.1186/1742-6405-7-31 |
0.338 |
|
| 2010 |
Levin A, Hayouka Z, Friedler A, Loyter A. Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells. Virology Journal. 7: 177. PMID 20678206 DOI: 10.1186/1743-422X-7-177 |
0.383 |
|
| 2010 |
Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, Byeon IJ, Gabizon R, Mattia M, Zupnick A, Brown LM, Friedler A, Prives C. The C terminus of p53 binds the N-terminal domain of MDM2. Nature Structural & Molecular Biology. 17: 982-9. PMID 20639885 DOI: 10.1038/Nsmb.1872 |
0.376 |
|
| 2010 |
Canello T, Frid K, Gabizon R, Lisa S, Friedler A, Moskovitz J, Gasset M, Gabizon R. Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP. Plos Pathogens. 6: e1000977. PMID 20625387 DOI: 10.1371/Journal.Ppat.1000977 |
0.325 |
|
| 2010 |
Levin A, Hayouka Z, Helfer M, Brack-Werner R, Friedler A, Loyter A. Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein. Biopolymers. 93: 740-51. PMID 20517955 DOI: 10.1002/Bip.21469 |
0.496 |
|
| 2010 |
Garty S, Kimelman-Bleich N, Hayouka Z, Cohn D, Friedler A, Pelled G, Gazit D. Peptide-modified "smart" hydrogels and genetically engineered stem cells for skeletal tissue engineering. Biomacromolecules. 11: 1516-26. PMID 20462241 DOI: 10.1021/Bm100157S |
0.333 |
|
| 2010 |
Reingewertz TH, Shalev DE, Friedler A. Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure. Protein and Peptide Letters. 17: 988-98. PMID 20450485 DOI: 10.2174/092986610791498876 |
0.429 |
|
| 2010 |
Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A. Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. Biochemical and Biophysical Research Communications. 394: 260-5. PMID 20171172 DOI: 10.1016/J.Bbrc.2010.02.100 |
0.467 |
|
| 2010 |
Levin A, Hayouka Z, Friedler A, Loyter A. Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells. Virus Genes. 40: 341-6. PMID 20151187 DOI: 10.1007/S11262-010-0458-7 |
0.442 |
|
| 2010 |
Levin A, Hayouka Z, Friedler A, Brack-Werner R, Volsky DJ, Loyter A. A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1. The Journal of General Virology. 91: 1503-13. PMID 20147519 DOI: 10.1099/Vir.0.019760-0 |
0.354 |
|
| 2010 |
Ronen D, Rosenberg MM, Shalev DE, Rosenberg M, Rotem S, Friedler A, Ravid S. The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly. The Journal of Biological Chemistry. 285: 7079-86. PMID 19959848 DOI: 10.1074/Jbc.M109.049221 |
0.377 |
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| 2010 |
Levin A, Rosenbluh J, Hayouka Z, Friedler A, Loyter A. Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins. Molecular Medicine (Cambridge, Mass.). 16: 34-44. PMID 19855849 DOI: 10.2119/Molmed.2009.00133 |
0.367 |
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| 2009 |
Levin A, Hayouka Z, Brack-Werner R, Volsky DJ, Friedler A, Loyter A. Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. Protein Engineering, Design & Selection : Peds. 22: 753-63. PMID 19875511 DOI: 10.1093/Protein/Gzp060 |
0.337 |
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| 2009 |
Maes M, Levin A, Hayouka Z, Shalev DE, Loyter A, Friedler A. Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. Bioorganic & Medicinal Chemistry. 17: 7635-42. PMID 19850483 DOI: 10.1016/J.Bmc.2009.09.053 |
0.487 |
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| 2009 |
Benyamini H, Leonov H, Rotem S, Katz C, Arkin IT, Friedler A. A model for the interaction between NF-kappa-B and ASPP2 suggests an I-kappa-B-like binding mechanism. Proteins. 77: 602-11. PMID 19507243 DOI: 10.1002/Prot.22473 |
0.425 |
|
| 2009 |
Reingewertz TH, Benyamini H, Lebendiker M, Shalev DE, Friedler A. The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state. Protein Engineering, Design & Selection : Peds. 22: 281-7. PMID 19218568 DOI: 10.1093/Protein/Gzp004 |
0.46 |
|
| 2009 |
Levin A, Hayouka Z, Helfer M, Brack-Werner R, Friedler A, Loyter A. Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. Plos One. 4: e4155. PMID 19127291 DOI: 10.1371/Journal.Pone.0004155 |
0.36 |
|
| 2009 |
Qvit N, Hatzubai A, Shalev DE, Friedler A, Ben-Neriah Y, Gilon C. Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model. Biopolymers. 91: 157-68. PMID 19025995 DOI: 10.1002/Bip.21098 |
0.654 |
|
| 2008 |
Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, Refaely H, Dines M, Bronner V, Bravman T, Shalev DE, Rüdiger S, Friedler A. Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proceedings of the National Academy of Sciences of the United States of America. 105: 12277-82. PMID 18719108 DOI: 10.1073/Pnas.0711269105 |
0.473 |
|
| 2008 |
Rotem S, Katz C, Benyamini H, Lebendiker M, Veprintsev D, Rüdiger S, Danieli T, Friedler A. The structure and interactions of the proline-rich domain of ASPP2. The Journal of Biological Chemistry. 283: 18990-9. PMID 18448430 DOI: 10.1074/Jbc.M708717200 |
0.46 |
|
| 2008 |
Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv MY, Feldstein A, Meushar S, Shalev DE, Friedler A, Gilon C. Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor. Journal of Combinatorial Chemistry. 10: 256-66. PMID 18271560 DOI: 10.1021/Cc700113C |
0.581 |
|
| 2008 |
Hayouka Z, Rosenbluh J, Levin A, Maes M, Loyter A, Friedler A. Peptides derived from HIV-1 Rev inhibit HIV-1 integrase in a shiftide mechanism. Biopolymers. 90: 481-7. PMID 18219678 DOI: 10.1002/Bip.20930 |
0.53 |
|
| 2008 |
Armon-Omer A, Levin A, Hayouka Z, Butz K, Hoppe-Seyler F, Loya S, Hizi A, Friedler A, Loyter A. Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library. Journal of Molecular Biology. 376: 971-82. PMID 18201721 DOI: 10.1016/J.Jmb.2007.11.095 |
0.523 |
|
| 2008 |
Gabizon R, Mor M, Rosenberg MM, Britan L, Hayouka Z, Kotler M, Shalev DE, Friedler A. Using peptides to study the interaction between the p53 tetramerization domain and HIV-1 Tat. Biopolymers. 90: 105-16. PMID 18189286 DOI: 10.1002/Bip.20919 |
0.502 |
|
| 2007 |
Rotem S, Katz C, Friedler A. Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2. Biochemical Society Transactions. 35: 966-9. PMID 17956256 DOI: 10.1042/Bst0350966 |
0.355 |
|
| 2007 |
Coster G, Hayouka Z, Argaman L, Strauss C, Friedler A, Brandeis M, Goldberg M. The DNA Damage Response Mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome Journal of Biological Chemistry. 282: 32053-32064. PMID 17827148 DOI: 10.1074/Jbc.M705890200 |
0.321 |
|
| 2007 |
Hayouka Z, Rosenbluh J, Levin A, Loya S, Lebendiker M, Veprintsev D, Kotler M, Hizi A, Loyter A, Friedler A. Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium. Proceedings of the National Academy of Sciences of the United States of America. 104: 8316-21. PMID 17488811 DOI: 10.1073/Pnas.0700781104 |
0.511 |
|
| 2007 |
Rosenbluh J, Hayouka Z, Loya S, Levin A, Armon-Omer A, Britan E, Hizi A, Kotler M, Friedler A, Loyter A. Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides. The Journal of Biological Chemistry. 282: 15743-53. PMID 17403681 DOI: 10.1074/Jbc.M609864200 |
0.483 |
|
| 2007 |
Karni-Schmidt O, Friedler A, Zupnick A, McKinney K, Mattia M, Beckerman R, Bouvet P, Sheetz M, Fersht A, Prives C. Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus. Oncogene. 26: 3878-91. PMID 17237827 DOI: 10.1038/Sj.Onc.1210162 |
0.488 |
|
| 2006 |
Diamant S, Podoly E, Friedler A, Ligumsky H, Livnah O, Soreq H. Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 103: 8628-33. PMID 16731619 DOI: 10.1073/Pnas.0602922103 |
0.403 |
|
| 2005 |
Friedler A, Veprintsev DB, Freund SM, von Glos KI, Fersht AR. Modulation of binding of DNA to the C-terminal domain of p53 by acetylation. Structure (London, England : 1993). 13: 629-36. PMID 15837201 DOI: 10.1016/J.Str.2005.01.020 |
0.524 |
|
| 2005 |
Friedler A, Veprintsev DB, Rutherford T, Von Glos KI, Fersht AR. Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53 Journal of Biological Chemistry. 280: 8051-8059. PMID 15611070 DOI: 10.1074/Jbc.M411176200 |
0.527 |
|
| 2005 |
Joerger AC, Friedler A, Fersht AR. Wild Type p53 conformation, structural consequences of p53 mutations and mechanisms of mutant p53 rescue 25 Years of P53 Research. 377-397. DOI: 10.1007/978-1-4020-2922-6_17 |
0.392 |
|
| 2004 |
Ekblad CM, Friedler A, Veprintsev D, Weinberg RL, Itzhaki LS. Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis. Protein Science : a Publication of the Protein Society. 13: 617-25. PMID 14978302 DOI: 10.1110/Ps.03461404 |
0.355 |
|
| 2004 |
Schon O, Friedler A, Freund S, Fersht AR. Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes. Journal of Molecular Biology. 336: 197-202. PMID 14741215 DOI: 10.1016/J.Jmb.2003.11.051 |
0.524 |
|
| 2004 |
Friedler A, DeDecker BS, Freund SM, Blair C, Rüdiger S, Fersht AR. Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation". Journal of Molecular Biology. 336: 187-96. PMID 14741214 DOI: 10.1016/J.Jmb.2003.12.005 |
0.458 |
|
| 2004 |
Seeliger MA, Breward SE, Friedler A, Schon O, Itzhaki LS. Erratum: Cooperative organization in a macromolecular complex Nature Structural & Molecular Biology. 11: 678-678. DOI: 10.1038/Nsmb0704-678B |
0.648 |
|
| 2003 |
Issaeva N, Friedler A, Bozko P, Wiman KG, Fersht AR, Selivanova G. Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide Proceedings of the National Academy of Sciences of the United States of America. 100: 13303-13307. PMID 14595027 DOI: 10.1073/Pnas.1835733100 |
0.559 |
|
| 2003 |
Seeliger MA, Breward SE, Friedler A, Schon O, Itzhaki LS. Cooperative organization in a macromolecular complex. Nature Structural Biology. 10: 718-24. PMID 12897769 DOI: 10.1038/Nsb962 |
0.607 |
|
| 2003 |
Friedler A, Veprintsev DB, Hansson LO, Fersht AR. Kinetic instability of p53 core domain mutants. Implications for rescue by small molecules Journal of Biological Chemistry. 278: 24108-24112. PMID 12700230 DOI: 10.1074/jbc.M302458200 |
0.489 |
|
| 2002 |
Schon O, Friedler A, Bycroft M, Freund SM, Fersht AR. Molecular mechanism of the interaction between MDM2 and p53. Journal of Molecular Biology. 323: 491-501. PMID 12381304 DOI: 10.1016/S0022-2836(02)00852-5 |
0.53 |
|
| 2002 |
Allen M, Friedler A, Schon O, Bycroft M. The structure of an FF domain from human HYPA/FBP11. Journal of Molecular Biology. 323: 411-6. PMID 12381297 DOI: 10.1016/S0022-2836(02)00968-3 |
0.336 |
|
| 2002 |
Baraz L, Hutoran M, Blumenzweig I, Katzenellenbogen M, Friedler A, Gilon C, Steinitz M, Kotler M. Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region. The Journal of General Virology. 83: 2225-30. PMID 12185277 DOI: 10.1099/0022-1317-83-9-2225 |
0.619 |
|
| 2002 |
Hansson LO, Friedler A, Freund S, Rudiger S, Fersht AR. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proceedings of the National Academy of Sciences of the United States of America. 99: 10305-9. PMID 12124396 DOI: 10.1073/Pnas.122347199 |
0.533 |
|
| 2002 |
Blumenzweig I, Baraz L, Friedler A, Danielson UH, Gilon C, Steinitz M, Kotler M. HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases. Biochemical and Biophysical Research Communications. 292: 832-40. PMID 11944889 DOI: 10.1006/Bbrc.2002.6732 |
0.63 |
|
| 2002 |
Hariton-Gazal E, Friedler D, Friedler A, Zakai N, Gilon C, Loyter A. Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence. Biochimica Et Biophysica Acta. 1594: 234-42. PMID 11904219 DOI: 10.1016/S0167-4838(01)00306-5 |
0.653 |
|
| 2002 |
Friedler A, Hansson LO, Veprintsev DB, Freund SM, Rippin TM, Nikolova PV, Proctor MR, Rüdiger S, Fersht AR. A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proceedings of the National Academy of Sciences of the United States of America. 99: 937-42. PMID 11782540 DOI: 10.1073/Pnas.241629998 |
0.526 |
|
| 2001 |
Schymkowitz JW, Rousseau F, Wilkinson HR, Friedler A, Itzhaki LS. Observation of signal transduction in three-dimensional domain swapping. Nature Structural Biology. 8: 888-92. PMID 11573096 DOI: 10.1038/Nsb1001-888 |
0.361 |
|
| 2000 |
Friedler A, Friedler D, Luedtke NW, Tor Y, Loyter A, Gilon C. Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif. The Journal of Biological Chemistry. 275: 23783-9. PMID 10764789 DOI: 10.1074/Jbc.M002200200 |
0.674 |
|
| 1999 |
Friedler A, Zakai N, Karni O, Friedler D, Gilon C, Loyter A. Identification of a nuclear transport inhibitory signal (NTIS) in the basic domain of HIV-1 Vif protein. Journal of Molecular Biology. 289: 431-7. PMID 10356319 DOI: 10.1006/Jmbi.1999.2785 |
0.67 |
|
| 1999 |
Friedler A, Blumenzweig I, Baraz L, Steinitz M, Kotler M, Gilon C. Peptides derived from HIV-1 Vif: a non-substrate based novel type of HIV-1 protease inhibitors. Journal of Molecular Biology. 287: 93-101. PMID 10074409 DOI: 10.1006/Jmbi.1998.2585 |
0.644 |
|
| 1998 |
Baraz L, Friedler A, Blumenzweig I, Nussinuv O, Chen N, Steinitz M, Gilon C, Kotler M. Human immunodeficiency virus type 1 Vif-derived peptides inhibit the viral protease and arrest virus production. Febs Letters. 441: 419-26. PMID 9891983 DOI: 10.1016/S0014-5793(98)01602-0 |
0.643 |
|
| 1998 |
Karni O, Friedler A, Zakai N, Gilon C, Loyter A. A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr. Febs Letters. 429: 421-5. PMID 9662462 DOI: 10.1016/S0014-5793(98)00645-0 |
0.65 |
|
| 1998 |
Friedler A, Zakai N, Karni O, Broder YC, Baraz L, Kotler M, Loyter A, Gilon C. Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells. Biochemistry. 37: 5616-22. PMID 9548947 DOI: 10.1021/Bi972878H |
0.642 |
|
| 1997 |
Broder YC, Stanhill A, Zakai N, Friedler A, Gilon C, Loyter A. Translocation of NLS-BSA conjugates into nuclei of permeabilized mammalian cells can be supported by protoplast extract. An experimental system for studying plant cytosolic factors involved in nuclear import. Febs Letters. 412: 535-9. PMID 9276462 DOI: 10.1016/S0014-5793(97)00855-7 |
0.526 |
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