Jun-Seok Lee, Ph.D, - Publications

Korea Institute of Science and Technology (KIST) 
Chemical biology

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kang SY, Yu JM, Kim HS, Lee JS, Yeon CM, Park KS, Choi SH, Lee SY. Influence of Orthodontic Anchor Screw Anchorage Method on the Stability of Artificial Bone: An In Vitro Study. Materials (Basel, Switzerland). 13. PMID 32708469 DOI: 10.3390/ma13143205  1
2020 Lee SH, Son DW, Lee JS, Sung SK, Lee SW, Song GS. Relationship Between Endplate Defects, Modic Change, Facet Joint Degeneration, and Disc Degeneration of Cervical Spine. Neurospine. 17: 443-452. PMID 32615702 DOI: 10.14245/ns.2040076.038  1
2020 Ryu JH, Lee JS, Lim CR, Cho WJ, Kim KW. Cerebrospinal fluid-cutaneous fistula associated with post-traumatic Charcot spinal arthropathy: a case report and review of literature. Bmc Musculoskeletal Disorders. 21: 412. PMID 32600397 DOI: 10.1186/s12891-020-03451-7  0.44
2020 Lee JS, Son DW, Lee SH, Ki SS, Lee SW, Song GS. Comparative Analysis of Surgical Outcomes of C1-2 Fusion Spine Surgery between Intraoperative Computed Tomography Image Based Navigation-Guided Operation and Fluoroscopy-Guided Operation. Journal of Korean Neurosurgical Society. 63: 237-247. PMID 32120457 DOI: 10.3340/jkns.2019.0172  1
2020 Kim KW, Jeong SW, Park HY, Heu JY, Jung HY, Lee JS. The effect of prolonged rhBMP-2 treatment on telomerase activity, replicative capacity and senescence of human nucleus pulposus cells. Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission. 1-9. PMID 32037884 DOI: 10.1080/10520295.2020.1721560  0.44
2019 Hwang JU, Son DW, Kang KT, Lee SH, Lee JS, Song GS, Lee SW, Sung SK. Importance of Hemoglobin A1c Levels for the Detection of Post-Surgical Infection Following Single-Level Lumbar Posterior Fusion in Patients with Diabetes. Korean Journal of Neurotrauma. 15: 150-158. PMID 31720269 DOI: 10.13004/kjnt.2019.15.e36  1
2019 Jeong H, Shin S, Lee JS, Lee SH, Baik JH, Lim S, Kim YK. Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau. International Journal of Molecular Sciences. 20. PMID 31480543 DOI: 10.3390/ijms20174283  1
2019 Lee JS, Rhee I. Functional Properties of a Pitch-Based Carbon Fiber-Mortar Composite as a Thin Overlay for Concrete Pavement. Materials (Basel, Switzerland). 12. PMID 31461967 DOI: 10.3390/ma12172753  0.6
2019 Kim JJ, Lee YA, Su D, Lee J, Park SJ, Kim B, Lee JHJ, Liu X, Kim SS, Bae MA, Lee JS, Hong SC, Wang L, Samanta A, Kwon HY, et al. A NIR probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society. PMID 31436967 DOI: 10.1021/jacs.9b06068  1
2019 Woo JB, Son DW, Lee SH, Lee JS, Lee SW, Song GS. Risk Factors of Allogenous Bone Graft Collapse in Two-Level Anterior Cervical Discectomy and Fusion. Journal of Korean Neurosurgical Society. 62: 450-457. PMID 31290298 DOI: 10.3340/jkns.2019.0008  1
2019 Lee CH, Son DW, Lee SH, Lee JS, Sung SK, Lee SW, Song GS. Radiological and Clinical Outcomes of Anterior Cervical Discectomy and Fusion in Elderly Patients: A Comparative Analysis of Young-Old Patients (Ages 65-74 Years) and Middle-Old Patients (Over 75 Years). Neurospine. PMID 31284342 DOI: 10.14245/ns.1836072.036  1
2019 Rhee I, Lee JS, Roh YS. Fracture Parameters of Cement Mortar with Different Structural Dimensions Under the Direct Tension Test. Materials (Basel, Switzerland). 12. PMID 31181601 DOI: 10.3390/ma12111850  0.6
2019 Haque MM, Murale DP, Kim YK, Lee JS. Crosstalk between Oxidative Stress and Tauopathy. International Journal of Molecular Sciences. 20. PMID 31013607 DOI: 10.3390/ijms20081959  1
2019 Lang W, Yuan C, Zhu B, Pan S, Liu J, Luo J, Nie S, Zhu Q, Lee JS, Ge J. Expanding the "minimalist" small molecule tagging approach to different bioactive compounds. Organic & Biomolecular Chemistry. PMID 30816385 DOI: 10.1039/c8ob03175d  0.36
2019 Jang SY, Murale DP, Kim AD, Lee JS. Recent developments in metal catalyzed bio-orthogonal reactions for biomolecule tagging. Chembiochem : a European Journal of Chemical Biology. PMID 30676678 DOI: 10.1002/cbic.201900052  1
2019 Yu JS, Hong SC, Wu S, Kim HM, Lee C, Lee JS, Lee JE, Kim KB. Differentiation of selectively labeled peptides using solid-state nanopores. Nanoscale. PMID 30672547 DOI: 10.1039/c8nr09315f  1
2019 Qian L, Pan S, Lee JS, Ge J, Li L, Yao SQ. Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes. Chemical Communications (Cambridge, England). PMID 30620026 DOI: 10.1039/c8cc09558b  0.36
2018 Murale DP, Hong SC, Jang SY, Lee JS. Reinvestigation of O-salicylaldehyde ester functional group in aqueous buffer and discovery of a coumarin scaffold probe for selective N-terminal cysteine labeling. Chembiochem : a European Journal of Chemical Biology. PMID 30325101 DOI: 10.1002/cbic.201800565  1
2018 Lee SH, Son DW, Lee JS, Sung SK, Lee SW, Song GS. Does Extension Dysfunction Affect Postoperative Loss of Cervical Lordosis in Patients who Undergo Laminoplasty? Spine. PMID 30260831 DOI: 10.1097/BRS.0000000000002887  1
2018 Hong SC, Murale DP, Jang SY, Haque MM, Seo M, Lee S, Woo DH, Kwon J, Song CS, Kim YK, Lee JS. Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe. Angewandte Chemie (International Ed. in English). PMID 29933516 DOI: 10.1002/anie.201804412  1
2018 Rhee I, Lee JS, Kim JB, Kim JH. Nitrogen Oxides Mitigation Efficiency of Cementitious Materials Incorporated with TiO₂. Materials (Basel, Switzerland). 11. PMID 29882935 DOI: 10.3390/ma11060877  1
2018 Bae SH, Son DW, Kwon OI, Lee SH, Lee JS, Song GS. Thickening Ligamentum Flavum Mimicking Tumor in the Epidural Space of the Cervical Spine. Korean Journal of Neurotrauma. 14: 43-46. PMID 29774200 DOI: 10.13004/kjnt.2018.14.1.43  0.4
2018 Lee SH, Son DW, Lee JS, Kim DH, Sung SK, Lee SW, Song GS. Differences in Cervical Sagittal Alignment Changes in Patients Undergoing Laminoplasty and Anterior Cervical Discectomy and Fusion. Neurospine. 15: 91-100. PMID 29656629 DOI: 10.14245/ns.1834864.432  1
2018 Murale DP, Hong SC, Haque MM, Lee JS. Chloro-functionalized photo-crosslinking BODIPY for glutathione sensing and sub-cellular trafficking. Chembiochem : a European Journal of Chemical Biology. PMID 29537726 DOI: 10.1002/cbic.201800059  1
2018 Kim DH, Lee SH, Lee JS, Song GS, Son DW. High thoracic ossification of ligamentum flavum causing partial Horner syndrome. British Journal of Neurosurgery. 1-2. PMID 29490510 DOI: 10.1080/02688697.2018.1441976  0.4
2018 Lee YA, Kim JJ, Lee J, Lee JHJ, Sahu S, Kwon HY, Park SJ, Jang SY, Lee JS, Wang Z, Tam WL, Lim B, Kang NY, Chang YT. Identification of Tumor Initiating Cells by a Small Molecule Fluorescent Probe through Vimentin as the Biomarker. Angewandte Chemie (International Ed. in English). PMID 29377425 DOI: 10.1002/anie.201712920  1
2018 Lee YC, Lee JS, Jung AR, Park JM, Eun YG. Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. Clinical and Experimental Otorhinolaryngology. PMID 29366304 DOI: 10.21053/ceo.2017.01319  0.64
2017 Pan S, Jang SY, Liew SS, Fu J, Wang D, Lee JS, Yao SQ. A Vinyl Sulfone-Based Fluorogenic Probe Capable of Selective Labeling of PHGDH in Live Mammalian Cells. Angewandte Chemie (International Ed. in English). PMID 29193627 DOI: 10.1002/anie.201710856  0.36
2017 Liew SS, Du S, Ge J, Pan S, Jang SY, Lee JS, Yao SQ. A chemoselective cleavable fluorescence turn-ON linker for proteomic studies. Chemical Communications (Cambridge, England). 53: 13332-13335. PMID 29188262 DOI: 10.1039/c7cc08235e  0.36
2017 Lee JS, Jung AR, Park JM, Park MJ, Lee YC, Eun YG. Comparison of Characteristics According to Reflux Type in Patients With Laryngopharyngeal Reflux. Clinical and Experimental Otorhinolaryngology. PMID 28993603 DOI: 10.21053/ceo.2017.00577  0.64
2017 Li Z, Cheng K, Lee JS, Yao SQ, Ding K. Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling and Sensitive Detection of a Cancer Biomarker. Angewandte Chemie (International Ed. in English). PMID 28967196 DOI: 10.1002/anie.201709584  0.36
2017 Hong SC, Murale DP, Lee M, Lee SM, Park J, Lee JS. Bulk aggregation based fluorescence turn-on sensors for selective detection of progesterone in aqueous solution. Angewandte Chemie (International Ed. in English). PMID 28960859 DOI: 10.1002/anie.201709120  1
2017 Lee DK, Kang JH, Kwon J, Lee JS, Lee S, Woo DH, Kim JH, Song CS, Park QH, Seo M. Nano metamaterials for ultrasensitive Terahertz biosensing. Scientific Reports. 7: 8146. PMID 28811551 DOI: 10.1038/s41598-017-08508-7  1
2017 Yao SQ, Pan S, Jang SY, Wang D, Liew SS, Li Z, Lee JS. A Suite of "Minimalist" Photo-Crosslinkers for Live-Cell Imaging and Chemical Proteomics: Case Study with BRD4 Inhibitors. Angewandte Chemie (International Ed. in English). PMID 28783236 DOI: 10.1002/anie.201706076  0.36
2017 Du S, Wang D, Lee JS, Peng B, Ge J, Yao SQ. Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues. Chemical Communications (Cambridge, England). PMID 28702584 DOI: 10.1039/c7cc04536k  0.36
2017 Wang D, Du S, Cazenave-Gassiot A, Ge J, Lee JS, Wenk MR, Yao SQ. Global Mapping of Protein-Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells. Angewandte Chemie (International Ed. in English). PMID 28429463 DOI: 10.1002/anie.201702509  0.36
2017 Lim S, Haque MM, Su D, Kim D, Lee JS, Chang YT, Kim YK. Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells. Chemical Communications (Cambridge, England). PMID 28084493 DOI: 10.1039/c6cc08826k  1
2016 Murale DP, Hong SC, Haque MM, Lee JS. Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs). Proteome Science. 15: 14. PMID 28652856 DOI: 10.1186/s12953-017-0123-3  1
2016 Zhu B, Zhang H, Pan S, Wang C, Ge J, Lee JS, Yao SQ. In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27115831 DOI: 10.1002/chem.201600259  0.36
2016 Hong SC, Murale DP, Lee JS. Combinatorial dansyl library and its applications to pH-responsive probes. Combinatorial Chemistry & High Throughput Screening. PMID 27055754  1
2016 Li Z, Qian L, Li L, Bernhammer JC, Huynh HV, Lee JS, Yao SQ. Corrigendum: Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications. Angewandte Chemie (International Ed. in English). 55: 3254. PMID 26915355 DOI: 10.1002/anie.201600314  0.36
2015 Li Z, Qian L, Li L, Bernhammer JC, Huynh HV, Lee JS, Yao SQ. Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications. Angewandte Chemie (International Ed. in English). PMID 26640085 DOI: 10.1002/anie.201508104  0.36
2015 Lee DK, Kang JH, Lee JS, Kim HS, Kim C, Hun Kim J, Lee T, Son JH, Park QH, Seo M. Highly sensitive and selective sugar detection by terahertz nano-antennas. Scientific Reports. 5: 15459. PMID 26494203 DOI: 10.1038/srep15459  1
2015 Kim D, Lim S, Haque MM, Ryoo N, Hong HS, Rhim H, Lee DE, Chang YT, Lee JS, Cheong E, Kim DJ, Kim YK. Identification of disulfide cross-linked tau dimer responsible for tau propagation. Scientific Reports. 5: 15231. PMID 26470054 DOI: 10.1038/srep15231  1
2015 Li L, Zhang CW, Ge J, Qian L, Chai BH, Zhu Q, Lee JS, Lim KL, Yao SQ. A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson's Disease. Angewandte Chemie (International Ed. in English). PMID 26205378 DOI: 10.1002/anie.201504441  0.36
2015 Yoo YH, Yun J, Yoon CN, Lee JS. Chemical proteomic identification of T-plastin as a novel host cell response factor in HCV infection. Scientific Reports. 5: 9773. PMID 25909246 DOI: 10.1038/srep09773  1
2015 Na HN, Yoo YH, Yoon CN, Lee JS. Unbiased proteomic profiling strategy for discovery of bacterial effector proteins reveals that salmonella protein PheA is a host cell cycle regulator. Chemistry & Biology. 22: 453-9. PMID 25865312 DOI: 10.1016/j.chembiol.2015.03.008  1
2015 Murale DP, Hong SC, Yun J, Yoon CN, Lee JS. Rational design of a photo-crosslinking BODIPY for in situ protein labeling. Chemical Communications (Cambridge, England). 51: 6643-6. PMID 25776928 DOI: 10.1039/c5cc01068c  1
2015 Lee JS, Lee JW, Kang N, Ha HH, Chang YT. Diversity-oriented approach for chemical biology. Chemical Record (New York, N.Y.). 15: 495-510. PMID 25676046 DOI: 10.1002/tcr.201402087  1
2015 Na Z, Peng B, Ng S, Pan S, Lee JS, Shen HM, Yao SQ. A small-molecule protein-protein interaction inhibitor of PARP1 that targets its BRCT domain. Angewandte Chemie (International Ed. in English). 54: 2515-9. PMID 25565365 DOI: 10.1002/anie.201410678  0.36
2014 Park SJ, Yeo HC, Kang NY, Kim H, Lin J, Ha HH, Vendrell M, Lee JS, Chandran Y, Lee DY, Yun SW, Chang YT. Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses. Stem Cell Research. 12: 730-41. PMID 24727632 DOI: 10.1016/j.scr.2014.03.002  1
2014 Lee JS, Yoo YH, Kang J, Han WS, Lee JK, Yoon CN. Proteome reactivity profiling for the discrimination of pathogenic bacteria. Chemical Communications (Cambridge, England). 50: 4347-50. PMID 24643251 DOI: 10.1039/c4cc00320a  1
2014 Yun SW, Kang NY, Park SJ, Ha HH, Kim YK, Lee JS, Chang YT. Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development. Accounts of Chemical Research. 47: 1277-86. PMID 24552450 DOI: 10.1021/ar400285f  1
2014 Lee JS, Yoo YH, Yoon CN. Small-molecule probes elucidate global enzyme activity in a proteomic context. Bmb Reports. 47: 149-57. PMID 24499666 DOI: 10.5483/BMBRep.2014.47.3.264  1
2013 Rhee HW, Lee SW, Lee JS, Chang YT, Hong JI. Focused fluorescent probe library for metal cations and biological anions. Acs Combinatorial Science. 15: 483-90. PMID 23947485 DOI: 10.1021/co400034x  1
2012 Lee JS, Kim YK, Kim HJ, Hajar S, Tan YL, Kang NY, Ng SH, Yoon CN, Chang YT. Identification of cancer cell-line origins using fluorescence image-based phenomic screening. Plos One. 7: e32096. PMID 22384151 DOI: 10.1371/journal.pone.0032096  1
2011 Lee JS, Vendrell M, Chang YT. Diversity-oriented optical imaging probe development. Current Opinion in Chemical Biology. 15: 760-7. PMID 22055497 DOI: 10.1016/j.cbpa.2011.10.007  1
2011 Vendrell M, Krishna GG, Ghosh KK, Zhai D, Lee JS, Zhu Q, Yau YH, Shochat SG, Kim H, Chung J, Chang YT. Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor. Chemical Communications (Cambridge, England). 47: 8424-6. PMID 21701752 DOI: 10.1039/c1cc11774b  1
2011 Kim YK, Lee JK, Lee JS, Yoon CN, Chang YT. Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain. Molecular Biosystems. 7: 2375-8. PMID 21660325 DOI: 10.1039/c1mb05137g  1
2011 Kim YK, Lee JS, Bi X, Ha HH, Ng SH, Ahn YH, Lee JJ, Wagner BK, Clemons PA, Chang YT. The binding of fluorophores to proteins depends on the cellular environment. Angewandte Chemie (International Ed. in English). 50: 2761-3. PMID 21370369 DOI: 10.1002/anie.201007626  1
2011 Ghosh KK, Yap E, Kim H, Lee JS, Chang YT. A colorimetric pH indicators and boronic acids ensemble array for quantitative sugar analysis. Chemical Communications (Cambridge, England). 47: 4001-3. PMID 21331385 DOI: 10.1039/c0cc04616g  1
2011 Lee JS, Kim HK, Feng S, Vendrell M, Chang YT. Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library. Chemical Communications (Cambridge, England). 47: 2339-41. PMID 21305064 DOI: 10.1039/c0cc04495d  1
2011 Lee JS, Baldridge A, Feng S, SiQiang Y, Kim YK, Tolbert LM, Chang YT. Fluorescence response profiling for small molecule sensors utilizing the green fluorescent protein chromophore and its derivatives. Acs Combinatorial Science. 13: 32-8. PMID 21247122 DOI: 10.1021/co100012k  1
2010 Schüller A, Goh GB, Kim H, Lee JS, Chang YT. Quantitative Structure-Fluorescence Property Relationship Analysis of a Large BODIPY Library. Molecular Informatics. 29: 717-29. PMID 27464015 DOI: 10.1002/minf.201000089  1
2010 Im CN, Kang NY, Ha HH, Bi X, Lee JJ, Park SJ, Lee SY, Vendrell M, Kim YK, Lee JS, Li J, Ahn YH, Feng B, Ng HH, Yun SW, et al. A fluorescent rosamine compound selectively stains pluripotent stem cells. Angewandte Chemie (International Ed. in English). 49: 7497-500. PMID 20814992 DOI: 10.1002/anie.201002463  1
2010 Hong MC, Kim YK, Choi JY, Yang SQ, Rhee H, Ryu YH, Choi TH, Cheon GJ, An GI, Kim HY, Kim Y, Kim DJ, Lee JS, Chang YT, Lee KC. Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques. Bioorganic & Medicinal Chemistry. 18: 7724-30. PMID 20621493 DOI: 10.1016/j.bmc.2010.06.044  1
2010 Vendrell M, Lee JS, Chang YT. Diversity-oriented fluorescence library approaches for probe discovery and development. Current Opinion in Chemical Biology. 14: 383-9. PMID 20227904 DOI: 10.1016/j.cbpa.2010.02.020  1
2010 Son J, Lee JJ, Lee JS, Schüller A, Chang YT. Isozyme-specific fluorescent inhibitor of glutathione s-transferase omega 1. Acs Chemical Biology. 5: 449-53. PMID 20205472 DOI: 10.1021/cb100007s  1
2010 Kim YK, Ha HH, Lee JS, Bi X, Ahn YH, Hajar S, Lee JJ, Chang YT. Control of muscle differentiation by a mitochondria-targeted fluorophore. Journal of the American Chemical Society. 132: 576-9. PMID 20020712 DOI: 10.1021/ja906862g  1
2009 Lee JS, Kang NY, Kim YK, Samanta A, Feng S, Kim HK, Vendrell M, Park JH, Chang YT. Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe. Journal of the American Chemical Society. 131: 10077-82. PMID 19621962 DOI: 10.1021/ja9011657  1
2009 Lee JS, Kim YK, Vendrell M, Chang YT. Diversity-oriented fluorescence library approach for the discovery of sensors and probes. Molecular Biosystems. 5: 411-21. PMID 19381357 DOI: 10.1039/b821766c  1
2008 Ahn YH, Lee JS, Chang YT. Selective human serum albumin sensor from the screening of a fluorescent rosamine library. Journal of Combinatorial Chemistry. 10: 376-80. PMID 18410151 DOI: 10.1021/cc800017h  1
2007 Lee JS, Lee JW, Chang YT. Counterion free colorimetric metal cation sensor array. Journal of Combinatorial Chemistry. 9: 926-8. PMID 17688318 DOI: 10.1021/cc070065z  1
2007 Lee JS, Chang YT. Understanding the activity of small molecules in the genomics context. Angewandte Chemie (International Ed. in English). 46: 3616-8. PMID 17407118 DOI: 10.1002/anie.200604972  1
2007 Ahn YH, Lee JS, Chang YT. Combinatorial rosamine library and application to in vivo glutathione probe. Journal of the American Chemical Society. 129: 4510-1. PMID 17378562 DOI: 10.1021/ja068230m  1
2006 Lee JW, Lee JS, Chang YT. Colorimetric identification of carbohydrates by a pH indicator/pH change inducer ensemble. Angewandte Chemie (International Ed. in English). 45: 6485-7. PMID 16977659 DOI: 10.1002/anie.200602055  1
2006 Lee JW, Lee JS, Kang M, Su AI, Chang YT. Visual artificial tongue for quantitative metal-cation analysis by an off-the-shelf dye array. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 5691-6. PMID 16715541 DOI: 10.1002/chem.200600307  1
2004 Li Q, Lee JS, Ha C, Park CB, Yang G, Gan WB, Chang YT. Solid-phase synthesis of styryl dyes and their application as amyloid sensors. Angewandte Chemie (International Ed. in English). 43: 6331-5. PMID 15558663 DOI: 10.1002/anie.200461600  1
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