Robert K Ernst - Publications

Microbial Pathogenesis University of Maryland Dental School, Baltimore, MD, United States 

207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Harberts E, Liang T, Yoon SH, Opene BN, McFarland MA, Goodlett DR, Ernst RK. Correction to "Toll-like Receptor 4-Independent Effects of Lipopolysaccharide Identified Using Longitudinal Serum Proteomics". Journal of Proteome Research. PMID 34793171 DOI: 10.1021/acs.jproteome.1c00855  1
2021 Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, ... ... Ernst RK, et al. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor-binding domain vaccine in aged mice. Science Translational Medicine. eabj5305. PMID 34783582 DOI: 10.1126/scitranslmed.abj5305  1
2021 Li H, Mattingly AE, Jania LA, Smith R, Melander RJ, Ernst RK, Koller BH, Melander C. Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants. Acs Infectious Diseases. 7: 3303-3313. PMID 34752055 DOI: 10.1021/acsinfecdis.1c00463  1
2021 Howlader DR, Das S, Lu T, Hu G, Varisco DJ, Dietz ZK, Walton SP, Ratnakaram SSK, Gardner FM, Ernst RK, Picking WD, Picking WL. Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against . Frontiers in Pharmacology. 12: 706157. PMID 34483911 DOI: 10.3389/fphar.2021.706157  1
2021 Haupt RE, Harberts EM, Kitz RJ, Strohmeier S, Krammer F, Ernst RK, Frieman MB. Novel TLR4 adjuvant elicits protection against homologous and heterologous Influenza A infection. Vaccine. PMID 34362603 DOI: 10.1016/j.vaccine.2021.06.085  1
2021 Ernst O, Khan MM, Oyler BL, Yoon SH, Sun J, Lin FY, Manes NP, MacKerell AD, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A. Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics. Msystems. e0030621. PMID 34342534 DOI: 10.1128/mSystems.00306-21  1
2021 Adamiak JW, Jhawar V, Bonifay V, Chandler CE, Leus IV, Ernst RK, Schweizer HP, Zgurskaya HI. Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in . Antimicrobial Agents and Chemotherapy. AAC0059221. PMID 34252310 DOI: 10.1128/AAC.00592-21  1
2021 Chattagul S, Khan MM, Scott AJ, Nita-Lazar A, Ernst RK, Goodlett DR, Sermswan RW. Transcriptomics Analysis Uncovers Transient Ceftazidime Tolerance in Biofilms. Acs Infectious Diseases. PMID 34138549 DOI: 10.1021/acsinfecdis.1c00003  1
2021 Ahn D, Bhushan G, McConville TH, Annavajhala MK, Soni RK, Wong Fok Lung T, Hofstaedter CE, Shah SS, Chong AM, Castano VG, Ernst RK, Uhlemann AC, Prince A. An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection. Cell Reports. 35: 109196. PMID 34077733 DOI: 10.1016/j.celrep.2021.109196  1
2021 Weig AW, Barlock SL, O'Connor PM, Marciano OM, Smith R, Ernst RK, Melander RJ, Melander C. A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors. Rsc Medicinal Chemistry. 12: 293-296. PMID 34046617 DOI: 10.1039/d0md00238k  1
2021 Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, ... ... Ernst RK, et al. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. Biorxiv : the Preprint Server For Biology. PMID 34031655 DOI: 10.1101/2021.05.20.444848  1
2021 Cross AS, Opal SM, Palardy JE, Shridhar S, Baliban SM, Scott AJ, Chahin AB, Ernst RK. A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis. Innate Immunity. 27: 266-274. PMID 33858243 DOI: 10.1177/17534259211007538  1
2021 Gauthier AE, Chandler CE, Poli V, Gardner FM, Tekiau A, Smith R, Bonham KS, Cordes EE, Shank TM, Zanoni I, Goodlett DR, Biller SJ, Ernst RK, Rotjan RD, Kagan JC. Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Science Immunology. 6. PMID 33712473 DOI: 10.1126/sciimmunol.abe0531  1
2021 Band VI, Satola SW, Smith RD, Hufnagel DA, Bower C, Conley AB, Rishishwar L, Dale SE, Hardy DJ, Vargas RL, Dumyati G, Kainer MA, Phipps EC, Pierce R, Wilson LE, ... ... Ernst RK, et al. Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant in the United States. Mbio. 12. PMID 33500343 DOI: 10.1128/mBio.02881-20  1
2021 Cetuk H, Anishkin A, Scott AJ, Rempe SB, Ernst RK, Sukharev S. Partitioning of Seven Different Classes of Antibiotics into LPS Monolayers Supports Three Different Permeation Mechanisms through the Outer Bacterial Membrane. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 33449700 DOI: 10.1021/acs.langmuir.0c02652  1
2020 Zacharia A, Harberts E, Valencia SM, Myers B, Sanders C, Jain A, Larson NR, Middaugh CR, Picking WD, Difilippantonio S, Kirnbauer R, Roden RB, Pinto LA, Shoemaker RH, Ernst RK, et al. Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists. Vaccine. PMID 33309485 DOI: 10.1016/j.vaccine.2020.11.066  1
2020 Sorensen M, Chandler CE, Gardner FM, Ramadan S, Khot PD, Leung LM, Farrance CE, Goodlett DR, Ernst RK, Nilsson E. Rapid microbial identification and colistin resistance detection via MALDI-TOF MS using a novel on-target extraction of membrane lipids. Scientific Reports. 10: 21536. PMID 33299017 DOI: 10.1038/s41598-020-78401-3  1
2020 Wolter DJ, Scott A, Armbruster CR, Whittington D, Edgar JS, Qin X, Buccat AM, McNamara S, Blackledge M, Waalkes A, Salipante SJ, Ernst RK, Hoffman LR. Repeated isolation of an antibiotic-dependent and temperature-sensitive mutant of Pseudomonas aeruginosa from a cystic fibrosis patient. The Journal of Antimicrobial Chemotherapy. PMID 33259594 DOI: 10.1093/jac/dkaa482  1
2020 Nelson N, Opene B, Ernst RK, Schwartz DK. Antimicrobial peptide activity is anticorrelated with lipid a leaflet affinity. Plos One. 15: e0242907. PMID 33253275 DOI: 10.1371/journal.pone.0242907  1
2020 Yang H, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ. Streamlined Analysis of Cardiolipins in Prokaryotic and Eukaryotic Samples Using Norharmane Matrix by MALDI-MSI. Journal of the American Society For Mass Spectrometry. PMID 32924474 DOI: 10.1021/Jasms.0C00201  1
2020 Yang H, Chandler CE, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ. On-tissue derivatization of lipopolysaccharide for detection of lipid A using MALDI-MSI. Analytical Chemistry. PMID 32902263 DOI: 10.1021/Acs.Analchem.0C02566  1
2020 Martínez-Limón A, Calloni G, Ernst R, Vabulas RM. Flavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency. Cell Death and Disease. 11: 725. PMID 32895367 DOI: 10.1038/S41419-020-02929-5  1
2020 Chandler CE, Harberts EM, Pelletier MR, Thaipisuttikul I, Jones JW, Hajjar AM, Sahl JW, Goodlett DR, Pride AC, Rasko DA, Trent MS, Bishop RE, Ernst RK. Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in . Proceedings of the National Academy of Sciences of the United States of America. PMID 32868431 DOI: 10.1073/Pnas.1917504117  1
2020 Leus IV, Adamiak J, Trinh AN, Smith RD, Smith L, Richardson S, Ernst RK, Zgurskaya HI. Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii. Molecular Microbiology. PMID 32858760 DOI: 10.1111/Mmi.14594  1
2020 Reinhard J, Mattes C, Väth K, Radanović T, Surma MA, Klose C, Ernst R. A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids. Frontiers in Cell and Developmental Biology. 8: 756. PMID 32850859 DOI: 10.3389/Fcell.2020.00756  1
2020 Mattingly AE, Cox K, Smith R, Melander RJ, Ernst RK, Melander C. Screening an established natural product library identifies secondary metabolites that potentiate conventional antibiotics. Acs Infectious Diseases. PMID 32810395 DOI: 10.1021/Acsinfecdis.0C00259  1
2020 Perault AI, Chandler CE, Rasko DA, Ernst RK, Wolfgang MC, Cotter PA. Host Adaptation Predisposes Pseudomonas aeruginosa to Type VI Secretion System-Mediated Predation by the Burkholderia cepacia Complex. Cell Host & Microbe. PMID 32755549 DOI: 10.1016/J.Chom.2020.06.019  1
2020 Ngaage LM, Elegbede A, Brao K, Chopra K, Gowda AU, Nam AJ, Ernst RK, Shirtliff ME, Harro J, Rasko YM. The Efficacy of Breast Implant Irrigant Solutions: A Comparative Analysis Using an In Vitro Model. Plastic and Reconstructive Surgery. 146: 301-308. PMID 32740580 DOI: 10.1097/Prs.0000000000007028  1
2020 Brao KJ, Wille BP, Lieberman J, Ernst RK, Shirtliff ME, Harro JM. -transgenic BALB/c mice as a model of infections of the cystic fibrosis lung. Infection and Immunity. PMID 32631918 DOI: 10.1128/Iai.00237-20  1
2020 Ernst R, Ballweg S, Levental I. Corrigendum to "Cellular mechanisms of physicochemical membrane homeostasis" [Curr Opin Cell Biol (2018) 44-51]. Current Opinion in Cell Biology. 63: 212. PMID 32446588 DOI: 10.1016/J.Ceb.2020.04.007  1
2020 Richard K, Perkins DJ, Harberts EM, Song Y, Gopalakrishnan A, Shirey KA, Lai W, Vlk A, Mahurkar A, Nallar S, Hawkins LD, Ernst RK, Vogel SN. Dissociation of TRIF bias and adjuvanticity. Vaccine. PMID 32389496 DOI: 10.1016/J.Vaccine.2020.04.042  1
2020 Ryu SY, Wendt GA, Ernst RK, Goodlett DR. MGMS2: Membrane Glycolipid Mass Spectrum Simulator for polymicrobial samples. Rapid Communications in Mass Spectrometry : Rcm. e8824. PMID 32384576 DOI: 10.1002/Rcm.8824  1
2020 Ngaage LM, Elegbede A, Brao K, Chopra K, Gowda AU, Nam AJ, Ernst RK, Shirtliff ME, Harro J, Rasko YM. The efficacy of breast implant irrigant solutions: A comparative analysis utilising an in-vitro model. Plastic and Reconstructive Surgery. PMID 32379180 DOI: 10.1097/PRS.0000000000007028  1
2020 Cetuk H, Maramba J, Britt M, Scott AJ, Ernst RK, Mihailescu M, Cotten ML, Sukharev S. Differential interactions of Piscidins with phospholipids and lipopolysaccharides at membrane interfaces. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 32306736 DOI: 10.1021/Acs.Langmuir.0C00017  1
2020 Heinrich F, Salyapongse A, Kumagai A, Dupuy FG, Shukla K, Penk A, Huster D, Ernst RK, Pavlova A, Gumbart JC, Deslouches B, Di YP, Tristram-Nagle S. Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32166806 DOI: 10.1002/Chem.202000212  1
2020 Levental KR, Malmberg E, Symons JL, Fan YY, Chapkin RS, Ernst R, Levental I. Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness. Nature Communications. 11: 1339. PMID 32165635 DOI: 10.1038/S41467-020-15203-1  1
2020 Harberts E, Liang T, Yoon SH, Opene BN, McFarland MA, Goodlett DR, Ernst RK. TLR4-Independent Effects of LPS Identified Using Longitudinal Serum Proteomics. Journal of Proteome Research. PMID 32037835 DOI: 10.1021/Acs.Jproteome.9B00765  1
2020 Ballweg S, Sezgin E, Doktorova M, Covino R, Reinhard J, Wunnicke D, Hänelt I, Levental I, Hummer G, Ernst R. Regulation of lipid saturation without sensing membrane fluidity. Nature Communications. 11: 756. PMID 32029718 DOI: 10.1038/S41467-020-14528-1  1
2020 Ernst R. Emerging role of the unfolded protein response in ER membrane homeostasis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00119  0.01
2020 Ernst R, Covino R, Hummer G, Reinhard J, Mattes C, Vaeth K, Hach J. A Biophysical Basis for Chronic Diseases Associated with ER Stress-Ire1 is Activated by Lipid Bilayer Stress and Perpetuates the Unfolded Protein Response Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1012  1
2019 Scott AJ, Chandler CE, Ellis SR, Heeren RMA, Ernst RK. Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging. Scientific Reports. 9: 20160. PMID 31882724 DOI: 10.1038/S41598-019-56364-4  1
2019 Crépin S, Ottosen EN, Chandler CE, Sintsova A, Ernst RK, Mobley HLT. The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii. Molecular Microbiology. PMID 31680352 DOI: 10.1111/Mmi.14407  1
2019 Sengyee S, Yoon SH, West TE, Ernst RK, Chantratita N. Lipopolysaccharides of different species with different lipid A structures induce TLR4 activation and react with melioidosis patient sera. Infection and Immunity. PMID 31548320 DOI: 10.1128/Iai.00692-19  1
2019 Barker W, Nemeth A, Brackett S, Basak A, Chandler CE, Jania L, Zuercher W, Melander RJ, Koller B, Ernst RK, Melander C. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria. Acs Infectious Diseases. PMID 31434474 DOI: 10.1021/Acsinfecdis.9B00212  1
2019 Krishnamoorthy G, Weeks JW, Zhang Z, Chandler C, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI. Efflux pumps of control the permeability barrier of the outer membrane. Antimicrobial Agents and Chemotherapy. PMID 31383661 DOI: 10.1128/Aac.00956-19  1
2019 Ryu SY, Wendt GA, Chandler CE, Ernst RK, Goodlett DR. Model-based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids. Analytical Chemistry. PMID 31369253 DOI: 10.1021/Acs.Analchem.9B03340  1
2019 Martin S, Melander RJ, Brackett C, Scott AJ, Chandler CE, Nguyen C, Minrovic B, Harrill S, Ernst RK, Manoil C, Melander C. Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii. Acs Infectious Diseases. PMID 31002491 DOI: 10.1021/Acsinfecdis.9B00067  1
2019 Kutschera A, Dawid C, Gisch N, Schmid C, Raasch L, Gerster T, Schäffer M, Smakowska-Luzan E, Belkhadir Y, Vlot AC, Chandler CE, Schellenberger R, Schwudke D, Ernst RK, Dorey S, et al. Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in plants. Science (New York, N.Y.). 364: 178-181. PMID 30975887 DOI: 10.1126/Science.Aau1279  1
2019 Barker WT, Chandler CE, Melander RJ, Ernst RK, Melander C. Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria. Bioorganic & Medicinal Chemistry. PMID 30898435 DOI: 10.1016/J.Bmc.2019.03.019  1
2019 Cooke AC, Nello AV, Ernst RK, Schertzer JW. Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis. Plos One. 14: e0212275. PMID 30763382 DOI: 10.1371/Journal.Pone.0212275  1
2019 Khan MM, Chattagul S, Tran BQ, Freiberg JA, Nita-Lazar A, Shirtliff ME, Sermswan RW, Ernst RK, Goodlett DR. Temporal proteomic profiling reveals changes that support Burkholderia biofilms. Pathogens and Disease. PMID 30759239 DOI: 10.1093/Femspd/Ftz005  1
2019 Kumagai A, Dupuy FG, Arsov Z, Elhady Y, Moody D, Ernst RK, Deslouches B, Montelaro RC, Peter Di Y, Tristram-Nagle S. Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers. Soft Matter. PMID 30702120 DOI: 10.1039/C8Sm02180E  1
2018 Liang T, Leung LM, Opene B, Fondrie WE, Lee YI, Chandler CE, Yoon SH, Doi Y, Ernst RK, Goodlett DR. Rapid microbial identification and antibiotic resistance detection by mass spectrometric analysis of membrane lipids. Analytical Chemistry. PMID 30571097 DOI: 10.1021/Acs.Analchem.8B02611  1
2018 Leung LM, McElheny CL, Gardner FM, Chandler CE, Bowler SL, Mettus RT, Spychala CN, Fowler EL, Opene BNA, Myers RA, Goodlett DR, Doi Y, Ernst RK. A Prospective Study of Complex Isolates and Colistin Susceptibility Monitoring by Mass Spectrometry of Microbial Membrane Glycolipids. Journal of Clinical Microbiology. PMID 30567747 DOI: 10.1128/Jcm.01100-18  1
2018 Chandler CE, Horspool AM, Hill PJ, Wozniak DJ, Schertzer JW, Rasko DA, Ernst RK. Genomic and phenotypic diversity among ten laboratory isolates of PAO1. Journal of Bacteriology. PMID 30530517 DOI: 10.1128/Jb.00595-18  1
2018 Fondrie WE, Liang T, Oyler BL, Leung LM, Ernst RK, Strickland DK, Goodlett DR. Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids. Scientific Reports. 8: 15857. PMID 30367087 DOI: 10.1038/S41598-018-33681-8  1
2018 Mustapha MM, Li B, Pacey MP, Mettus RT, McElheny CL, Marshall CW, Ernst RK, Cooper VS, Doi Y. Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii. The Journal of Antimicrobial Chemotherapy. PMID 30124845 DOI: 10.1093/Jac/Dky290  1
2018 Covino R, Hummer G, Ernst R. Integrated Functions of Membrane Property Sensors and a Hidden Side of the Unfolded Protein Response. Molecular Cell. 71: 458-467. PMID 30075144 DOI: 10.1016/J.Molcel.2018.07.019  1
2018 Guillotte ML, Gillespie JJ, Chandler CE, Rahman MS, Ernst RK, Azad AF. Lipid A biosynthesis utilizes the late acyltransferase LpxJ for secondary fatty acid addition. Journal of Bacteriology. PMID 30012728 DOI: 10.1128/Jb.00334-18  1
2018 Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell C, Scott AJ, Ernst RK. intradermal delivery of bacteria using microneedle arrays. Infection and Immunity. PMID 29986891 DOI: 10.1128/Iai.00406-18  1
2018 Khan MM, Ernst O, Sun J, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A. Mass spectrometry based structural analysis and systems immunoproteomics strategies for deciphering the host response to endotoxin. Journal of Molecular Biology. PMID 29949751 DOI: 10.1016/J.Jmb.2018.06.032  1
2018 Hofbauer HF, Gecht M, Fischer SC, Seybert A, Frangakis AS, Stelzer EHK, Covino R, Hummer G, Ernst R. The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1. The Journal of Cell Biology. PMID 29941475 DOI: 10.1083/Jcb.201802027  1
2018 Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK. A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model. Vaccine. PMID 29861179 DOI: 10.1016/J.Vaccine.2018.05.101  1
2018 Ernst R, Ballweg S, Levental I. Cellular mechanisms of physicochemical membrane homeostasis. Current Opinion in Cell Biology. 53: 44-51. PMID 29787971 DOI: 10.1016/J.Ceb.2018.04.013  1
2018 Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR. Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate. Journal of the American Society For Mass Spectrometry. PMID 29687418 DOI: 10.1007/S13361-018-1960-8  1
2018 Radanović T, Reinhard J, Ballweg S, Pesek K, Ernst R. An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e1700250. PMID 29574931 DOI: 10.1002/Bies.201700250  1
2018 Sengyee S, Yoon SH, Paksanont S, Yimthin T, Wuthiekanun V, Limmathurotsakul D, West TE, Ernst RK, Chantratita N. Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation. Plos Neglected Tropical Diseases. 12: e0006287. PMID 29474381 DOI: 10.1371/Journal.Pntd.0006287  1
2018 Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR. Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate. Journal of the American Society For Mass Spectrometry. PMID 29464544 DOI: 10.1007/S13361-018-1897-Y  1
2018 Ernst R. Decision letter: Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2 Elife. DOI: 10.7554/Elife.40686.046  0.01
2017 Crawford MA, Fisher DJ, Leung LM, Lomonaco S, Lascols C, Cannatelli A, Giani T, Rossolini GM, Doi Y, Goodlett DR, Allard MW, Sharma SK, Khan E, Ernst RK, Hughes MA. CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens. Mbio. 8. PMID 29138303 DOI: 10.1128/Mbio.01549-17  1
2017 Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK. Host-based lipid inflammation drives pathogenesis in Francisella infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109289 DOI: 10.1073/Pnas.1712887114  1
2017 Kopp Y, Lang WH, Schuster TB, Martínez-Limón A, Hofbauer HF, Ernst R, Calloni G, Vabulas RM. CHIP as a membrane-shuttling proteostasis sensor. Elife. 6. PMID 29091030 DOI: 10.7554/Elife.29388  1
2017 Hajjar AM, Ernst RK, Yi J, Yam CS, Miller SI. Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness. Plos One. 12: e0186308. PMID 29020088 DOI: 10.1371/Journal.Pone.0186308  1
2017 Zhang YF, Han K, Chandler CE, Tjaden B, Ernst RK, Lory S. Probing the sRNA regulatory landscape of P. aeruginosa: post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility. Molecular Microbiology. PMID 28976035 DOI: 10.1111/Mmi.13857  1
2017 Leung LM, Cooper VS, Rasko DA, Guo Q, Pacey MP, McElheny CL, Mettus RT, Yoon SH, Goodlett DR, Ernst RK, Doi Y. Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae. The Journal of Antimicrobial Chemotherapy. PMID 28961916 DOI: 10.1093/Jac/Dkx234  1
2017 Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C. Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria. Bioorganic & Medicinal Chemistry. PMID 28958847 DOI: 10.1016/J.Bmc.2017.08.055  1
2017 Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M. Structural basis of MsbA-mediated lipopolysaccharide transport. Nature. PMID 28869968 DOI: 10.1038/Nature23649  1
2017 Chandler CE, Ernst RK. Bacterial lipids: powerful modifiers of the innate immune response. F1000research. 6. PMID 28868130 DOI: 10.12688/F1000Research.11388.1  1
2017 Robert CB, Thomson M, Vercellone A, Gardner F, Ernst RK, Larrouy-Maumus G, Nigou J. Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress. Biochimie. PMID 28807561 DOI: 10.1016/J.Biochi.2017.08.008  0.08
2017 Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, et al. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. Journal of Cell Science. PMID 28794014 DOI: 10.1242/Jcs.201715  1
2017 Halbleib K, Pesek K, Covino R, Hofbauer HF, Wunnicke D, Hänelt I, Hummer G, Ernst R. Activation of the Unfolded Protein Response by Lipid Bilayer Stress. Molecular Cell. 67: 673-684.e8. PMID 28689662 DOI: 10.1016/J.Molcel.2017.06.012  1
2017 Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK. Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery. Mbio. 8. PMID 28487429 DOI: 10.1128/Mbio.00492-17  1
2017 Liu YY, Chandler CE, Leung LM, McElheny CL, Mettus RT, Shanks RM, Liu JH, Goodlett DR, Ernst RK, Doi Y. Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens. Antimicrobial Agents and Chemotherapy. PMID 28373195 DOI: 10.1128/Aac.00580-17  1
2017 Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, ... ... Ernst RK, et al. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. 8: 14401. PMID 28195158 DOI: 10.1038/Ncomms14401  1
2017 Scott AJ, Oyler BL, Goodlett DR, Ernst RK. Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship. Biochimica Et Biophysica Acta. PMID 28108356 DOI: 10.1016/J.Bbalip.2017.01.004  1
2017 Richard K, Mann BJ, Qin A, Barry EM, Ernst RK, Vogel SN. Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity. Clinical and Vaccine Immunology : Cvi. PMID 28077440 DOI: 10.1128/Cvi.00574-16  1
2017 Ballweg S, Ernst R. Control of membrane fluidity: the OLE pathway in focus. Biological Chemistry. 398: 215-228. PMID 27787227 DOI: 10.1515/Hsz-2016-0277  1
2017 Kopp Y, Lang W, Schuster TB, Martínez-Limón A, Hofbauer HF, Ernst R, Calloni G, Vabulas RM. Author response: CHIP as a membrane-shuttling proteostasis sensor Elife. DOI: 10.7554/Elife.29388.018  1
2017 Chen Q, Lawrenz A, Wang A, Kelly E, Harberts E, Ernst RK, Tong J. Abstract 4021: Donor-specific primary monocyte-derived dendritic cell maturation model for high-throughput screening of immunostimulatory adjuvants Cancer Research. 77: 4021-4021. DOI: 10.1158/1538-7445.Am2017-4021  1
2016 Jones CL, Singh SS, Alamneh Y, Casella LG, Ernst RK, Lesho EP, Waterman PE, Zurawski DV. In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress. Antimicrobial Agents and Chemotherapy. PMID 27993849 DOI: 10.1128/Aac.00598-16  1
2016 Freiberg JA, Le Breton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Mongodin EF, Goodlett DR, McIver KS, Shirtliff ME. Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms. Msystems. 1. PMID 27933318 DOI: 10.1128/mSystems.00149-16  1
2016 Kilgour DP, Hughes S, Kilgour SL, Mackay CL, Palmblad M, Tran BQ, Goo YA, Ernst RK, Clarke DJ, Goodlett DR. Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 27924495 DOI: 10.1007/S13361-016-1549-Z  1
2016 Corey BW, Thompson MG, Hittle LE, Jacobs AC, Asafo-Adjei EA, Huggins W, Melander RJ, Melander C, Ernst RK, Zurawski DV. 1, 2, 4 -Triazolidine-3-thiones have specific activity against Acinetobacter baumannii amongst common nosocomial pathogens. Acs Infectious Diseases. PMID 27764938 DOI: 10.1021/Acsinfecdis.6B00133  1
2016 Scott AJ, Flinders B, Cappell J, Liang T, Pelc RS, Tran B, Kilgour DP, Heeren RM, Goodlett DR, Ernst RK. Norharmane Matrix Enhances Detection of Endotoxin by MALDI-MS for Simultaneous Profiling of Pathogen, Host, and Vector Systems. Pathogens and Disease. PMID 27650574 DOI: 10.1093/Femspd/Ftw097  1
2016 Yoon SH, Liang T, Schneider T, Oyler BL, Chandler CE, Ernst RK, Yen GS, Huang Y, Nilsson E, Goodlett DR. Rapid Lipid A Structure Determination via Surface Acoustic Wave Nebulization and Hierarchical Tandem Mass Spectrometry Algorithm. Rapid Communications in Mass Spectrometry : Rcm. PMID 27582344 DOI: 10.1002/Rcm.7728  1
2016 SenGupta S, Hittle LE, Ernst RK, Uriarte SM, Mitchell TC. A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils. Journal of Leukocyte Biology. PMID 27538572 DOI: 10.1189/Jlb.4Vma0316-101R  1
2016 Ernst R, Ejsing CS, Antonny B. Homeoviscous Adaptation and the Regulation of Membrane Lipids. Journal of Molecular Biology. 428: 4776-4791. PMID 27534816 DOI: 10.1016/J.Jmb.2016.08.013  0.01
2016 Li Y, Yoon SH, Wang X, Ernst RK, Goodlett DR. Structural Derivation of lipid A from Cronobacter sakazakii using Tandem Mass Spectrometry. Rapid Communications in Mass Spectrometry : Rcm. PMID 27502448 DOI: 10.1002/Rcm.7712  1
2016 Brackett CM, Furlani RE, Anderson RG, Krishnamurthy A, Melander RJ, Moskowitz SM, Ernst RK, Melander C. Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity. Tetrahedron. 72: 3549-3553. PMID 27429479 DOI: 10.1016/J.Tet.2015.09.019  1
2016 Maldarelli GA, Piepenbrink KH, Scott AJ, Freiberg JA, Song Y, Achermann Y, Ernst RK, Shirtliff ME, Sundberg EJ, Donnenberg MS, von Rosenvinge EC. Type IV pili promote early biofilm formation by Clostridium difficile. Pathogens and Disease. PMID 27369898 DOI: 10.1093/Femspd/Ftw061  1
2016 Covino R, Ballweg S, Stordeur C, Michaelis JB, Puth K, Wernig F, Bahrami A, Ernst AM, Hummer G, Ernst R. A Eukaryotic Sensor for Membrane Lipid Saturation. Molecular Cell. PMID 27320200 DOI: 10.1016/J.Molcel.2016.05.015  1
2016 Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C. Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. Medchemcomm. 7: 128-131. PMID 26877862 DOI: 10.1039/C5Md00353A  1
2015 Renzi F, Zähringer U, Chandler CE, Ernst RK, Cornelis GR, Ittig SJ. Modification of the 1-phosphate group during biosynthesis of Capnocytophaga canimorsus lipid A. Infection and Immunity. PMID 26644381 DOI: 10.1128/Iai.01006-15  1
2015 Varga JJ, Barbier M, Mulet X, Bielecki P, Bartell JA, Owings JP, Martinez-Ramos I, Hittle LE, Davis MR, Damron FH, Liechti GW, Puchałka J, Dos Santos VA, Ernst RK, Papin JA, et al. Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains. Bmc Genomics. 16: 883. PMID 26519161 DOI: 10.1186/S12864-015-2069-0  1
2015 Chin CY, Gregg KA, Napier BA, Ernst RK, Weiss DS. A PmrB-regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. PMID 26459891 DOI: 10.1128/Aac.00515-15  1
2015 Hittle LE, Powell DA, Jones JW, Tofigh M, Goodlett DR, Moskowitz SM, Ernst RK. Site-specific activity of the acyltransferases HtrB1 and HtrB2 in Pseudomonas aeruginosa lipid A biosynthesis. Pathogens and Disease. PMID 26223882 DOI: 10.1093/Femspd/Ftv053  1
2015 Puth K, Hofbauer HF, Sáenz JP, Ernst R. Homeostatic control of biological membranes by dedicated lipid and membrane packing sensors. Biological Chemistry. 396: 1043-58. PMID 25849795 DOI: 10.1515/Hsz-2015-0130  1
2015 Qureshi ZA, Hittle LE, O'Hara JA, Rivera JI, Syed A, Shields RK, Pasculle AW, Ernst RK, Doi Y. Colistin-resistant Acinetobacter baumannii: beyond carbapenem resistance. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 60: 1295-303. PMID 25632010 DOI: 10.1093/Cid/Civ048  1
2015 Reinhart AA, Powell DA, Nguyen AT, O'Neill M, Djapgne L, Wilks A, Ernst RK, Oglesby-Sherrouse AG. The prrF-encoded small regulatory RNAs are required for iron homeostasis and virulence of Pseudomonas aeruginosa. Infection and Immunity. 83: 863-75. PMID 25510881 DOI: 10.1128/Iai.02707-14  1
2015 Hittle LE, Jones JW, Hajjar AM, Ernst RK, Preston A. Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A. Journal of Bacteriology. 197: 572-80. PMID 25422302 DOI: 10.1128/Jb.02236-14  1
2014 Knodler LA, Crowley SM, Sham HP, Yang H, Wrande M, Ma C, Ernst RK, Steele-Mortimer O, Celli J, Vallance BA. Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host & Microbe. 16: 249-56. PMID 25121752 DOI: 10.1016/J.Chom.2014.07.002  1
2014 Mehla J, Ernst R, Moore R, Wakschlag A, Marquis MK, Ambudkar SV, Golin J. Evidence for a molecular diode-based mechanism in a multispecific ATP-binding cassette (ABC) exporter: SER-1368 as a gatekeeping residue in the yeast multidrug transporter Pdr5 Journal of Biological Chemistry. 289: 26597-26606. PMID 25112867 DOI: 10.1074/Jbc.M114.586032  1
2014 Chirakul S, Bartpho T, Wongsurawat T, Taweechaisupapong S, Karoonutaisiri N, Talaat AM, Wongratanacheewin S, Ernst RK, Sermswan RW. Characterization of BPSS1521 (bprD), a regulator of Burkholderia pseudomallei virulence gene expression in the mouse model Plos One. 9. PMID 25111708 DOI: 10.1371/Journal.Pone.0104313  1
2014 Pilla DM, Hagar JA, Haldar AK, Mason AK, Degrandi D, Pfeffer K, Ernst RK, Yamamoto M, Miao EA, Coers J. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proceedings of the National Academy of Sciences of the United States of America. 111: 6046-51. PMID 24715728 DOI: 10.1073/Pnas.1321700111  1
2014 Rolin O, Muse SJ, Safi C, Elahi S, Gerdts V, Hittle LE, Ernst RK, Harvill ET, Preston A. Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission. Infection and Immunity. 82: 491-9. PMID 24478065 DOI: 10.1128/Iai.01260-12  1
2014 Richard K, Mann BJ, Stocker L, Barry EM, Qin A, Cole LE, Hurley MT, Ernst RK, Michalek SM, Stein DC, Deshong P, Vogel SN. Novel catanionic surfactant vesicle vaccines protect against Francisella tularensis LVS and confer significant partial protection against F. tularensis Schu S4 strain. Clinical and Vaccine Immunology : Cvi. 21: 212-26. PMID 24351755 DOI: 10.1128/Cvi.00738-13  1
2014 Thaipisuttikul I, Hittle LE, Chandra R, Zangari D, Dixon CL, Garrett TA, Rasko DA, Dasgupta N, Moskowitz SM, Malmström L, Goodlett DR, Miller SI, Bishop RE, Ernst RK. A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis-specific lipid A. Molecular Microbiology. 91: 158-74. PMID 24283944 DOI: 10.1111/Mmi.12451  1
2014 Scott AJ, Jones JW, Orschell CM, Macvittie TJ, Kane MA, Ernst RK. Mass spectrometry imaging enriches biomarker discovery approaches with Candidate mapping Health Physics. 106: 120-128. PMID 24276555 DOI: 10.1097/Hp.0B013E3182A4Ec2F  1
2014 Jones JW, Scott AJ, Tudor G, Xu PT, Jackson IL, Vujaskovic Z, Booth C, Macvittie TJ, Ernst RK, Kane MA. Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry Health Physics. 106: 106-119. PMID 24276554 DOI: 10.1097/Hp.0B013E3182A4Ed3B  1
2014 Stordeur C, Puth K, Sáenz JP, Ernst R. Crosstalk of lipid and protein homeostasis to maintain membrane function Biological Chemistry. 395: 313-326. PMID 24152902 DOI: 10.1515/Hsz-2013-0235  1
2014 Harris TL, Worthington RJ, Hittle LE, Zurawski DV, Ernst RK, Melander C. Small molecule downregulation of PmrAB reverses lipid a modification and breaks colistin resistance Acs Chemical Biology. 9: 122-127. PMID 24131198 DOI: 10.1021/Cb400490K  1
2014 Knodler LA, Crowley SM, Sham HP, Yang H, Wrande M, Ma C, Ernst RK, Steele-Mortimer O, Celli J, Vallance BA. Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens Cell Host and Microbe. 16: 249-256. DOI: 10.1016/j.chom.2014.07.002  1
2013 Chantratita N, Tandhavanant S, Myers ND, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle LE, Ernst RK, Emond MJ, Wurfel MM, Day NP, Peacock SJ, West TE. Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide. Plos One. 8: e81617. PMID 24303060 DOI: 10.1371/Journal.Pone.0081617  1
2013 Li Y, Wang Z, Chen J, Ernst RK, Wang X. Influence of lipid A acylation pattern on membrane permeability and innate immune stimulation. Marine Drugs. 11: 3197-208. PMID 24065161 DOI: 10.3390/Md11093197  1
2013 Hagar JA, Powell DA, Aachoui Y, Ernst RK, Miao EA. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science (New York, N.Y.). 341: 1250-3. PMID 24031018 DOI: 10.1126/Science.1240988  1
2013 Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R, Simons K, Krogan NJ, Ernst R. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Molecular Cell. 51: 519-30. PMID 23891562 DOI: 10.1016/J.Molcel.2013.06.014  1
2013 Pelletier MR, Casella LG, Jones JW, Adams MD, Zurawski DV, Hazlett KR, Doi Y, Ernst RK. Unique structural modifications are present in the lipopolysaccharide from colistin-resistant strains of Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. 57: 4831-40. PMID 23877686 DOI: 10.1128/Aac.00865-13  1
2013 Nchoutmboube JA, Viktorova EG, Scott AJ, Ford LA, Pei Z, Watkins PA, Ernst RK, Belov GA. Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles. Plos Pathogens. 9: e1003401. PMID 23762027 DOI: 10.1371/Journal.Ppat.1003401  1
2013 Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, et al. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature. 497: 498-502. PMID 23636320 DOI: 10.1038/Nature12118  1
2013 Rebeil R, Jarrett CO, Driver JD, Ernst RK, Oyston PC, Hinnebusch BJ. Induction of the Yersinia pestis PhoP-PhoQ regulatory system in the flea and its role in producing a transmissible infection. Journal of Bacteriology. 195: 1920-30. PMID 23435973 DOI: 10.1128/Jb.02000-12  1
2013 O'Hara JA, Ambe LA, Casella LG, Townsend BM, Pelletier MR, Ernst RK, Shanks RM, Doi Y. Activities of vancomycin-containing regimens against colistin-resistant Acinetobacter baumannii clinical strains. Antimicrobial Agents and Chemotherapy. 57: 2103-8. PMID 23422916 DOI: 10.1128/Aac.02501-12  1
2013 Morin N, Santiago AE, Ernst RK, Guillot SJ, Nataro JP. Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infection and Immunity. 81: 122-32. PMID 23090962 DOI: 10.1128/Iai.00676-12  0.01
2012 Powell DA, Li Y, Ernst RK. Turning up Francisella pathogenesis: the LPS thermostat. Virulence. 3: 594-6. PMID 23154289 DOI: 10.4161/Viru.22496  1
2012 Hajjar AM, Ernst RK, Fortuno ES, Brasfield AS, Yam CS, Newlon LA, Kollmann TR, Miller SI, Wilson CB. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica. Plos Pathogens. 8: e1002963. PMID 23071439 DOI: 10.1371/Journal.Ppat.1002963  1
2012 Yoon SH, Huang Y, Edgar JS, Ting YS, Heron SR, Kao Y, Li Y, Masselon CD, Ernst RK, Goodlett DR. Surface acoustic wave nebulization facilitating lipid mass spectrometric analysis. Analytical Chemistry. 84: 6530-7. PMID 22742654 DOI: 10.1021/Ac300807P  1
2012 Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK. LPS remodeling is an evolved survival strategy for bacteria. Proceedings of the National Academy of Sciences of the United States of America. 109: 8716-21. PMID 22586119 DOI: 10.1073/Pnas.1202908109  1
2012 Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infection and Immunity. 80: 943-51. PMID 22215738 DOI: 10.1128/Iai.06109-11  1
2012 Klein KA, Fukuto HS, Pelletier M, Romanov G, Grabenstein JP, Palmer LE, Ernst R, Bliska JB. A transposon site hybridization screen identifies galU and wecBC as important for survival of Yersinia pestis in murine macrophages. Journal of Bacteriology. 194: 653-62. PMID 22139502 DOI: 10.1128/Jb.06237-11  1
2012 Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CRH, Ernst RK. LPS remodeling is an evolved survival strategy for bacteria (Proceedings of the National Academy of Sciences United States of America (2012) 109, (8716-8721) DOI: 10.1073/pnas.1202908109)) Proceedings of the National Academy of Sciences of the United States of America. 109: 13877. DOI: 10.1073/Pnas.1212463109  1
2011 Li Y, Wang X, Ernst RK. A rapid one-step method for the characterization of membrane lipid remodeling in Francisella using matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 25: 2641-8. PMID 23657959 DOI: 10.1002/Rcm.5168  1
2011 Galen JE, Simon R, Ernst RK. Salmonella expressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens. Expert Review of Vaccines. 10: 1679-82. PMID 22085171 DOI: 10.1586/Erv.11.155  1
2011 Scott A, Weldon S, Buchanan PJ, Schock B, Ernst RK, McAuley DF, Tunney MM, Irwin CR, Elborn JS, Taggart CC. Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo. Plos One. 6: e26525. PMID 22028895 DOI: 10.1371/Journal.Pone.0026525  1
2011 Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM. Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis. Infection and Immunity. 79: 4240-9. PMID 21807909 DOI: 10.1128/Iai.05484-11  1
2011 MacArthur I, Jones JW, Goodlett DR, Ernst RK, Preston A. Role of pagL and lpxO in Bordetella bronchiseptica lipid A biosynthesis. Journal of Bacteriology. 193: 4726-35. PMID 21764941 DOI: 10.1128/Jb.01502-10  1
2011 Damron FH, Davis MR, Withers TR, Ernst RK, Goldberg JB, Yu G, Yu HD. Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1. Molecular Microbiology. 81: 554-70. PMID 21631603 DOI: 10.1111/J.1365-2958.2011.07715.X  1
2011 Ting YS, Shaffer SA, Jones JW, Ng WV, Ernst RK, Goodlett DR. Automated lipid A structure assignment from hierarchical tandem mass spectrometry data. Journal of the American Society For Mass Spectrometry. 22: 856-66. PMID 21472520 DOI: 10.1007/S13361-010-0055-Y  1
2011 Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL. Enzymatic blockade of the ubiquitin-proteasome pathway. Plos Biology. 8: e1000605. PMID 21468303 DOI: 10.1371/Journal.Pbio.1000605  1
2011 Jassem AN, Zlosnik JE, Henry DA, Hancock RE, Ernst RK, Speert DP. In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides. Antimicrobial Agents and Chemotherapy. 55: 2256-64. PMID 21321142 DOI: 10.1128/Aac.01434-10  1
2011 Gupta RP, Kueppers P, Schmitt L, Ernst R. The multidrug transporter Pdr5: a molecular diode? Biological Chemistry. 392: 53-60. PMID 21194365 DOI: 10.1515/Bc.2011.011  1
2011 Jumpertz T, Tschapek B, Infed N, Smits SHJ, Ernst R, Schmitt L. High-throughput evaluation of the critical micelle concentration of detergents. Analytical Biochemistry. 408: 64-70. PMID 20850411 DOI: 10.1016/J.Ab.2010.09.011  1
2010 Soni S, Ernst RK, Muszy?ski A, Mohapatra NP, Perry MB, Vinogradov E, Carlson RW, Gunn JS. Francisella tularensis blue-gray phase variation involves structural modifications of lipopolysaccharide o-antigen, core and lipid a and affects intramacrophage survival and vaccine efficacy. Frontiers in Microbiology. 1: 129. PMID 21687776 DOI: 10.3389/Fmicb.2010.00129  1
2010 Lai XH, Shirley RL, Crosa L, Kanistanon D, Tempel R, Ernst RK, Gallagher LA, Manoil C, Heffron F. Mutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophages. Plos One. 5: e11857. PMID 20686600 DOI: 10.1371/Journal.Pone.0011857  1
2010 Moskowitz SM, Ernst RK. The role of Pseudomonas lipopolysaccharide in cystic fibrosis airway infection. Sub-Cellular Biochemistry. 53: 241-53. PMID 20593270 DOI: 10.1007/978-90-481-9078-2_11  1
2010 Jones JW, Cohen IE, Tureĉek F, Goodlett DR, Ernst RK. Comprehensive structure characterization of lipid A extracted from Yersinia pestis for determination of its phosphorylation configuration. Journal of the American Society For Mass Spectrometry. 21: 785-99. PMID 20185334 DOI: 10.1016/J.Jasms.2010.01.008  1
2010 Ernst R, Kueppers P, Stindt J, Kuchler K, Schmitt L. Multidrug efflux pumps: Substrate selection in ATP‐binding cassette multidrug efflux pumps – first come, first served? Febs Journal. 277: 540-549. PMID 19961541 DOI: 10.1111/J.1742-4658.2009.07485.X  1
2009 Ernst R, Mueller B, Ploegh HL, Schlieker C. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Molecular Cell. 36: 28-38. PMID 19818707 DOI: 10.1016/J.Molcel.2009.09.016  1
2009 Pilonieta MC, Erickson KD, Ernst RK, Detweiler CS. A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC. Journal of Bacteriology. 191: 7243-52. PMID 19767429 DOI: 10.1128/Jb.00688-09  1
2009 Buchanan PJ, Ernst RK, Elborn JS, Schock B. Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation. Biochemical Society Transactions. 37: 863-7. PMID 19614608 DOI: 10.1042/Bst0370863  1
2009 Coats SR, Jones JW, Do CT, Braham PH, Bainbridge BW, To TT, Goodlett DR, Ernst RK, Darveau RP. Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activities. Cellular Microbiology. 11: 1587-99. PMID 19552698 DOI: 10.1111/J.1462-5822.2009.01349.X  1
2009 Berezow AB, Ernst RK, Coats SR, Braham PH, Karimi-Naser LM, Darveau RP. The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses. Microbial Pathogenesis. 47: 68-77. PMID 19460428 DOI: 10.1016/J.Micpath.2009.04.015  1
2009 Antos JM, Popp MW, Ernst R, Chew GL, Spooner E, Ploegh HL. A straight path to circular proteins. The Journal of Biological Chemistry. 284: 16028-36. PMID 19359246 DOI: 10.1074/Jbc.M901752200  1
2009 Kalhorn TF, Kiavand A, Cohen IE, Nelson AK, Ernst RK. A sensitive liquid chromatography/mass spectrometry-based assay for quantitation of amino-containing moieties in lipid A. Rapid Communications in Mass Spectrometry : Rcm. 23: 433-42. PMID 19130491 DOI: 10.1002/Rcm.3900  1
2008 Jones JW, Shaffer SA, Ernst RK, Goodlett DR, Turecek F. Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach. Proceedings of the National Academy of Sciences of the United States of America. 105: 12742-7. PMID 18753624 DOI: 10.1073/Pnas.0800445105  1
2008 West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ. Activation of Toll-like receptors by Burkholderia pseudomallei. Bmc Immunology. 9: 46. PMID 18691413 DOI: 10.1186/1471-2172-9-46  1
2008 Bainbridge BW, Karimi-Naser L, Reife R, Blethen F, Ernst RK, Darveau RP. Acyl chain specificity of the acyltransferases LpxA and LpxD and substrate availability contribute to lipid A fatty acid heterogeneity in Porphyromonas gingivalis. Journal of Bacteriology. 190: 4549-58. PMID 18456814 DOI: 10.1128/Jb.00234-08  1
2008 Ernst R, Kueppers P, Klein CM, Schwarzmueller T, Kuchler K, Schmitt L. A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5 Proceedings of the National Academy of Sciences of the United States of America. 105: 5069-5074. PMID 18356296 DOI: 10.1073/Pnas.0800191105  1
2008 Kanistanon D, Hajjar AM, Pelletier MR, Gallagher LA, Kalhorn T, Shaffer SA, Goodlett DR, Rohmer L, Brittnacher MJ, Skerrett SJ, Ernst RK. A Francisella mutant in lipid A carbohydrate modification elicits protective immunity. Plos Pathogens. 4: e24. PMID 18266468 DOI: 10.1371/Journal.Ppat.0040024  1
2008 Miao EA, Ernst RK, Dors M, Mao DP, Aderem A. Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proceedings of the National Academy of Sciences of the United States of America. 105: 2562-7. PMID 18256184 DOI: 10.1073/Pnas.0712183105  1
2007 Ernst RK, Moskowitz SM, Emerson JC, Kraig GM, Adams KN, Harvey MD, Ramsey B, Speert DP, Burns JL, Miller SI. Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis. The Journal of Infectious Diseases. 196: 1088-92. PMID 17763333 DOI: 10.1086/521367  1
2007 Rohmer L, Fong C, Abmayr S, Wasnick M, Larson Freeman TJ, Radey M, Guina T, Svensson K, Hayden HS, Jacobs M, Gallagher LA, Manoil C, Ernst RK, Drees B, Buckley D, et al. Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biology. 8: R102. PMID 17550600 DOI: 10.1186/Gb-2007-8-6-R102  1
2007 D'Argenio DA, Wu M, Hoffman LR, Kulasekara HD, Déziel E, Smith EE, Nguyen H, Ernst RK, Larson Freeman TJ, Spencer DH, Brittnacher M, Hayden HS, Selgrade S, Klausen M, Goodlett DR, et al. Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Molecular Microbiology. 64: 512-33. PMID 17493132 DOI: 10.1111/J.1365-2958.2007.05678.X  1
2007 Mohapatra NP, Soni S, Bell BL, Warren R, Ernst RK, Muszynski A, Carlson RW, Gunn JS. Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes. Infection and Immunity. 75: 3305-14. PMID 17452468 DOI: 10.1128/Iai.00351-07  1
2007 Murray SR, Ernst RK, Bermudes D, Miller SI, Low KB. pmrA(Con) confers pmrHFIJKL-dependent EGTA and polymyxin resistance on msbB Salmonella by decorating lipid A with phosphoethanolamine. Journal of Bacteriology. 189: 5161-9. PMID 17449614 DOI: 10.1128/Jb.01969-06  1
2007 Shaffer SA, Harvey MD, Goodlett DR, Ernst RK. Structural heterogeneity and environmentally regulated remodeling of Francisella tularensis subspecies novicida lipid A characterized by tandem mass spectrometry. Journal of the American Society For Mass Spectrometry. 18: 1080-92. PMID 17446084 DOI: 10.1016/J.Jasms.2007.03.008  1
2007 Waters VJ, Gómez MI, Soong G, Amin S, Ernst RK, Prince A. Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Infection and Immunity. 75: 1698-703. PMID 17220304 DOI: 10.1128/Iai.01469-06  0.01
2007 Haagensen JA, Klausen M, Ernst RK, Miller SI, Folkesson A, Tolker-Nielsen T, Molin S. Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms. Journal of Bacteriology. 189: 28-37. PMID 17041046 DOI: 10.1128/Jb.00720-06  1
2006 Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjöstedt A, Edebro H, Forsman M, Byström M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infection and Immunity. 74: 6730-8. PMID 16982824 DOI: 10.1128/Iai.00934-06  1
2006 Ernst R, Koch J, Horn C, Tampé R, Schmitt L. Engineering ATPase activity in the isolated ABC cassette of human TAP1. The Journal of Biological Chemistry. 281: 27471-80. PMID 16864587 DOI: 10.1074/Jbc.M601131200  1
2006 Rebeil R, Ernst RK, Jarrett CO, Adams KN, Miller SI, Hinnebusch BJ. Characterization of late acyltransferase genes of Yersinia pestis and their role in temperature-dependent lipid A variation. Journal of Bacteriology. 188: 1381-8. PMID 16452420 DOI: 10.1128/Jb.188.4.1381-1388.2006  1
2006 Ernst RK, Adams KN, Moskowitz SM, Kraig GM, Kawasaki K, Stead CM, Trent MS, Miller SI. The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. Journal of Bacteriology. 188: 191-201. PMID 16352835 DOI: 10.1128/Jb.188.1.191-201.2006  1
2006 Bylund J, Burgess LA, Cescutti P, Ernst RK, Speert DP. Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species. The Journal of Biological Chemistry. 281: 2526-32. PMID 16316987 DOI: 10.1074/Jbc.M510692200  1
2005 Ernst R, Klemm R, Schmitt L, Kuchler K. Yeast ATP-binding cassette transporters: cellular cleaning pumps. Methods in Enzymology. 400: 460-84. PMID 16399365 DOI: 10.1016/S0076-6879(05)00026-1  1
2005 Kawasaki K, Ernst RK, Miller SI. Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium. Journal of Endotoxin Research. 11: 57-61. PMID 15826380 DOI: 10.1179/096805105225006696  1
2005 Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infection and Immunity. 73: 2312-20. PMID 15784576 DOI: 10.1128/Iai.73.4.2312-2320.2005  1
2005 Kawasaki K, Ernst RK, Miller SI. Inhibition of Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation by aminoarabinose membrane modification. Journal of Bacteriology. 187: 2448-57. PMID 15774888 DOI: 10.1128/Jb.187.7.2448-2457.2005  1
2005 Beckmann C, Brittnacher M, Ernst R, Mayer-Hamblett N, Miller SI, Burns JL. Use of phage display to identify potential Pseudomonas aeruginosa gene products relevant to early cystic fibrosis airway infections. Infection and Immunity. 73: 444-52. PMID 15618183 DOI: 10.1128/Iai.73.1.444-452.2005  1
2005 Miller SI, Ernst RK, Bader MW. LPS, TLR4 and infectious disease diversity. Nature Reviews. Microbiology. 3: 36-46. PMID 15608698 DOI: 10.1038/Nrmicro1068  1
2004 Kawasaki K, Ernst RK, Miller SI. Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4. Journal of Endotoxin Research. 10: 439-44. PMID 15588428 DOI: 10.1179/096805104225006264  1
2004 Rebeil R, Ernst RK, Gowen BB, Miller SI, Hinnebusch BJ. Variation in lipid A structure in the pathogenic yersiniae. Molecular Microbiology. 52: 1363-73. PMID 15165239 DOI: 10.1111/J.1365-2958.2004.04059.X  1
2004 Skerrett SJ, Liggitt HD, Hajjar AM, Ernst RK, Miller SI, Wilson CB. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L143-52. PMID 15047567 DOI: 10.1152/Ajplung.00030.2004  1
2004 Kawasaki K, Ernst RK, Miller SI. 3-O-deacylation of lipid A by PagL, a PhoP/PhoQ-regulated deacylase of Salmonella typhimurium, modulates signaling through Toll-like receptor 4. The Journal of Biological Chemistry. 279: 20044-8. PMID 15014080 DOI: 10.1074/Jbc.M401275200  1
2004 Moskowitz SM, Ernst RK, Miller SI. PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. Journal of Bacteriology. 186: 575-9. PMID 14702327 DOI: 10.1128/Jb.186.2.575-579.2004  1
2003 Ernst RK, Hajjar AM, Tsai JH, Moskowitz SM, Wilson CB, Miller SI. Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4. Journal of Endotoxin Research. 9: 395-400. PMID 14733728 DOI: 10.1179/096805103225002764  1
2003 Ernst RK, D'Argenio DA, Ichikawa JK, Bangera MG, Selgrade S, Burns JL, Hiatt P, McCoy K, Brittnacher M, Kas A, Spencer DH, Olson MV, Ramsey BW, Lory S, Miller SI. Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis. Environmental Microbiology. 5: 1341-9. PMID 14641578 DOI: 10.1111/J.1462-2920.2003.00518.X  1
2003 Guina T, Wu M, Miller SI, Purvine SO, Yi EC, Eng J, Goodlett DR, Aebersold R, Ernst RK, Lee KA. Proteomic analysis of Pseudomonas aeruginosa grown under magnesium limitation. Journal of the American Society For Mass Spectrometry. 14: 742-51. PMID 12837596 DOI: 10.1016/S1044-0305(03)00133-8  1
2003 Benabdelhak H, Kiontke S, Horn C, Ernst R, Blight MA, Holland IB, Schmitt L. A specific interaction between the NBD of the ABC-transporter HlyB and a C-terminal fragment of its transport substrate haemolysin A. Journal of Molecular Biology. 327: 1169-79. PMID 12662939 DOI: 10.1016/S0022-2836(03)00204-3  1
2002 Brodsky IE, Ernst RK, Miller SI, Falkow S. mig-14 is a Salmonella gene that plays a role in bacterial resistance to antimicrobial peptides. Journal of Bacteriology. 184: 3203-13. PMID 12029036 DOI: 10.1128/Jb.184.12.3203-3213.2002  1
2002 Hajjar AM, Ernst RK, Tsai JH, Wilson CB, Miller SI. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nature Immunology. 3: 354-9. PMID 11912497 DOI: 10.1038/Ni777  1
2001 Ernst RK, Guina T, Miller SI. Salmonella typhimurium outer membrane remodeling: Role in resistance to host innate immunity Microbes and Infection. 3: 1327-1334. PMID 11755422 DOI: 10.1016/S1286-4579(01)01494-0  1
2001 Pérez-Melgosa M, Ochs HD, Linsley PS, Laman JD, Van Meurs M, Flavell RA, Ernst RK, Miller SI, Wilson CB. Carrier-mediated enhancement of cognate T cell help: The basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine European Journal of Immunology. 31: 2373-2381. PMID 11500820 DOI: 10.1002/1521-4141(200108)31:8<2373::Aid-Immu2373>3.0.Co;2-G  1
2000 Yethon JA, Gunn JS, Ernst RK, Miller SI, Laroche L, Malo D, Whitfield C. Salmonella enterica serovar typhimurium waaP mutants show increased susceptibility to polymyxin and loss of virulence In vivo. Infection and Immunity. 68: 4485-91. PMID 10899846 DOI: 10.1128/Iai.68.8.4485-4491.2000  1
2000 Gunn JS, Ernst RK, McCoy AJ, Miller SI. Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP. Infection and Immunity. 68: 3758-62. PMID 10816543 DOI: 10.1128/Iai.68.6.3758-3762.2000  1
2000 Ernst RK, Miller SI. Peptides, Pseudomonas aeruginosa, polysaccharides and lipopolysaccharides - Players in the predicament of cystic fibrosis patients: Response Trends in Microbiology. 8: 250-251. DOI: 10.1016/S0966-842X(00)01744-3  1
1999 Ernst RK, Yi EC, Guo L, Lim KB, Burns JL, Hackett M, Miller SI. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa Science. 286: 1561-1565. PMID 10567263 DOI: 10.1126/Science.286.5444.1561  1
1999 Ernst RK, Guina T, Miller SI. How intracellular bacteria survive: Surface modifications that promote resistance to host innate immune responses Journal of Infectious Diseases. 179. PMID 10081503 DOI: 10.1086/513850  1
1997 Pasquinelli AE, Ernst RK, Lund E, Grimm C, Zapp ML, Rekosh D, Hammarskjöld ML, Dahlberg JE. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. The Embo Journal. 16: 7500-10. PMID 9405378 DOI: 10.1093/Emboj/16.24.7500  1
1997 Ernst RK, Bray M, Rekosh D, Hammarskjöld ML. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA Molecular and Cellular Biology. 17: 135-144. PMID 8972193 DOI: 10.1128/Mcb.17.1.135  1
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