Year |
Citation |
Score |
2020 |
Shan Y, Si R, Wang J, Zhang Q, Li J, Ma Y, Zhang J. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. European Journal of Medicinal Chemistry. 205: 112654. PMID 32750566 DOI: 10.1016/J.Ejmech.2020.112654 |
0.331 |
|
2019 |
Pan X, Liang L, Sun Y, Si R, Zhang Q, Wang J, Fu J, Zhang J, Zhang J. Discovery of novel Bcr-Abl inhibitors with flexible linker. Part 1: Confirmation optimization of phenyl-1H-indazol-3-amine as hinge binding moiety. European Journal of Medicinal Chemistry. 178: 232-242. PMID 31185413 DOI: 10.1016/J.Ejmech.2019.05.091 |
0.388 |
|
2019 |
Wang J, Chen Q, Shan Y, Pan X, Zhang J. Activity-based proteomic profiling: The application of photoaffinity probes in the target identification of bioactive molecules Trends in Analytical Chemistry. 115: 110-120. DOI: 10.1016/J.Trac.2019.03.028 |
0.302 |
|
2018 |
Shan Y, Si R, Wang J, Zhang Q, Zhou H, Song J, Zhang J, Chen Q. Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs. European Journal of Medicinal Chemistry. 164: 440-447. PMID 30616052 DOI: 10.1016/J.Ejmech.2018.12.067 |
0.406 |
|
2018 |
Pan X, Liang L, Si R, Wang J, Zhang Q, Zhou H, Zhang L, Zhang J. Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol. European Journal of Medicinal Chemistry. 163: 1-9. PMID 30503935 DOI: 10.1016/J.Ejmech.2018.11.042 |
0.403 |
|
2018 |
Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J, He L. A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncology Reports. PMID 29901176 DOI: 10.3892/Or.2018.6472 |
0.325 |
|
2018 |
Shan Y, Wang B, Zhang J. New strategies in achieving antiangiogenic effect: Multiplex inhibitors suppressing compensatory activations of RTKs. Medicinal Research Reviews. PMID 29878411 DOI: 10.1002/Med.21517 |
0.492 |
|
2017 |
Zhang L, Shan Y, Ji X, Zhu M, Li C, Sun Y, Si R, Pan X, Wang J, Ma W, Dai B, Wang B, Zhang J. Discovery and evaluation of triple inhibitors of VEGFR-2, TIE-2 and EphB4 as anti-angiogenic and anti-cancer agents. Oncotarget. 8: 104745-104760. PMID 29285210 DOI: 10.18632/Oncotarget.20065 |
0.524 |
|
2017 |
Li C, Shan Y, Sun Y, Si R, Liang L, Pan X, Wang B, Zhang J. Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4. European Journal of Medicinal Chemistry. PMID 29102175 DOI: 10.1016/J.Ejmech.2017.10.030 |
0.496 |
|
2017 |
Sun Y, Shan Y, Li C, Si R, Pan X, Wang B, Zhang J. Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors. European Journal of Medicinal Chemistry. 141: 373-385. PMID 29032031 DOI: 10.1016/J.Ejmech.2017.10.008 |
0.51 |
|
2017 |
Zhang J, Shi Y, Zheng Y, Pan C, Yang X, Dou T, Wang B, Lu W. Homing in on an intracellular target for delivery of loaded nanoparticles functionalized with a histone deacetylase inhibitor. Oncotarget. 8: 68242-68251. PMID 28978112 DOI: 10.18632/Oncotarget.20021 |
0.431 |
|
2017 |
Wang J, Zhang L, Pan X, Dai B, Sun Y, Li C, Zhang J. Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents. Scientific Reports. 7: 45145. PMID 28332573 DOI: 10.1038/Srep45145 |
0.398 |
|
2017 |
Zhang L, Shan Y, Li C, Sun Y, Su P, Wang J, Li L, Pan X, Zhang J. Discovery of novel anti-angiogenesis agents. Part 6: Multi-targeted RTK inhibitors. European Journal of Medicinal Chemistry. 127: 275-285. PMID 28068599 DOI: 10.1016/J.Ejmech.2016.12.059 |
0.413 |
|
2015 |
Wang C, Wang T, Huang L, Lu W, Zhang J, He H. Synthesis and fluorescent study of 5-phenyl furocoumarin derivatives as vasodilatory agents. Bioorganic & Medicinal Chemistry Letters. PMID 26627580 DOI: 10.1016/J.Bmcl.2015.11.056 |
0.325 |
|
2015 |
Shan Y, Dong J, Pan X, Zhang L, Zhang J, Dong Y, Wang M. Expanding the structural diversity of Bcr-Abl inhibitors: Dibenzoylpiperazin incorporated with 1H-indazol-3-amine. European Journal of Medicinal Chemistry. 104: 139-147. PMID 26451772 DOI: 10.1016/J.Ejmech.2015.09.034 |
0.384 |
|
2015 |
Shan Y, Gao H, Shao X, Wang J, Pan X, Zhang J. Discovery of novel VEGFR-2 inhibitors. Part 5: Exploration of diverse hinge-binding fragments via core-refining approach. European Journal of Medicinal Chemistry. 103: 80-90. PMID 26342134 DOI: 10.1016/J.Ejmech.2015.08.045 |
0.416 |
|
2015 |
Dong J, Pan X, Wang J, Su P, Zhang L, Wei F, Zhang J. Synthesis and biological evaluation of novel aromatic-heterocyclic biphenyls as potent anti-leukemia agents. European Journal of Medicinal Chemistry. 101: 780-789. PMID 26231079 DOI: 10.1016/J.Ejmech.2015.07.015 |
0.403 |
|
2015 |
Pan X, Dong J, Shi Y, Shao R, Wei F, Wang J, Zhang J. Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as the flexible linker. Organic & Biomolecular Chemistry. 13: 7050-66. PMID 26052668 DOI: 10.1039/C5Ob00430F |
0.379 |
|
2015 |
Shi Y, Zhou M, Zhang J, Lu W. Preparation and cellular targeting study of VEGF-conjugated PLGA nanoparticles. Journal of Microencapsulation. 1-6. PMID 26004370 DOI: 10.3109/02652048.2015.1035683 |
0.311 |
|
2015 |
Su P, Wang J, Shi Y, Pan X, Shao R, Zhang J. Discovery of biphenyl-aryl ureas as novel VEGFR-2 inhibitors. Part 4: Exploration of diverse hinge-binding fragments. Bioorganic & Medicinal Chemistry. 23: 3228-36. PMID 25982075 DOI: 10.1016/J.Bmc.2015.04.071 |
0.388 |
|
2015 |
Lu W, Li P, Shan Y, Su P, Wang J, Shi Y, Zhang J. Discovery of biphenyl-based VEGFR-2 inhibitors. Part 3: design, synthesis and 3D-QSAR studies. Bioorganic & Medicinal Chemistry. 23: 1044-54. PMID 25637123 DOI: 10.1016/J.Bmc.2015.01.006 |
0.408 |
|
2015 |
Gao H, Su P, Shi Y, Shen X, Zhang Y, Dong J, Zhang J. Discovery of novel VEGFR-2 inhibitors. Part II: biphenyl urea incorporated with salicylaldoxime. European Journal of Medicinal Chemistry. 90: 232-40. PMID 25461323 DOI: 10.1016/J.Ejmech.2014.11.032 |
0.371 |
|
2014 |
Dong J, Lu W, Pan X, Su P, Shi Y, Wang J, Zhang J. Discovery of novel Bcr-Abl inhibitors targeting myristoyl pocket and ATP site. Bioorganic & Medicinal Chemistry. 22: 6876-84. PMID 25464886 DOI: 10.1016/J.Bmc.2014.10.030 |
0.346 |
|
2014 |
Dai B, Qi J, Liu R, Zhang J, Zhan Y, Zhang Y. A novel compound T7 (N-{4'-[(1E)-N-hydroxyethanimidoyl]-3',5,6-trimethoxybiphenyl-3-yl}-N'-[4-(3-morpholin-4-ylpropoxy)phenyl]urea) screened by tissue angiogenesis model and its activity evaluation on anti-angiogenesis. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 21: 1675-83. PMID 25442276 DOI: 10.1016/J.Phymed.2014.08.005 |
0.343 |
|
2014 |
Lu W, Wang F, Zhang T, Dong J, Gao H, Su P, Shi Y, Zhang J. Search for novel histone deacetylase inhibitors. Part II: design and synthesis of novel isoferulic acid derivatives. Bioorganic & Medicinal Chemistry. 22: 2707-13. PMID 24702857 DOI: 10.1016/J.Bmc.2014.03.019 |
0.365 |
|
2014 |
Pan X, Dong J, Gao H, Wang F, Zhang Y, Wang S, Zhang J. Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chemical Biology & Drug Design. 83: 592-9. PMID 24330598 DOI: 10.1111/Cbdd.12272 |
0.367 |
|
2014 |
Wang C, Gao H, Dong J, Zhang Y, Su P, Shi Y, Zhang J. Biphenyl derivatives incorporating urea unit as novel VEGFR-2 inhibitors: design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry. 22: 277-84. PMID 24315192 DOI: 10.1016/J.Bmc.2013.11.027 |
0.393 |
|
2014 |
Wang C, Gao H, Dong J, Wang F, Li P, Zhang J. Insight into the medicinal chemistry of EGFR and HER-2 inhibitors. Current Medicinal Chemistry. 21: 1336-1350. PMID 24251571 DOI: 10.2174/0929867320666131119124646 |
0.326 |
|
2013 |
Fu J, Cheng Y, Linghu J, Yang X, Kang L, Zhang Z, Zhang J, He C, Du X, Peng Z, Wang B, Zhai L, Dai C, Xu J, Wang W, et al. RNA sequencing reveals the complex regulatory network in the maize kernel. Nature Communications. 4: 2832. PMID 24343161 DOI: 10.1038/ncomms3832 |
0.353 |
|
2013 |
Wang F, Lu W, Zhang T, Dong J, Gao H, Li P, Wang S, Zhang J. Development of novel ferulic acid derivatives as potent histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry. 21: 6973-80. PMID 24095016 DOI: 10.1016/J.Bmc.2013.09.021 |
0.379 |
|
2013 |
Luo W, Wang X, Zheng L, Zhan Y, Zhang D, Zhang J, Zhang Y. Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway. Journal of Cellular and Molecular Medicine. 17: 1316-24. PMID 23905676 DOI: 10.1111/Jcmm.12108 |
0.342 |
|
2013 |
Zhou N, He JY, Wang T, Zhang J, He HZ. Design, synthesis, and vasorelaxation activity of novel imperatorin derivatives. Journal of Asian Natural Products Research. 15: 650-7. PMID 23659576 DOI: 10.1080/10286020.2013.790378 |
0.343 |
|
2013 |
Pan X, Wang F, Zhang Y, Gao H, Hu Z, Wang S, Zhang J. Design, synthesis and biological activities of Nilotinib derivates as antitumor agents. Bioorganic & Medicinal Chemistry. 21: 2527-34. PMID 23538233 DOI: 10.1016/J.Bmc.2013.02.036 |
0.377 |
|
2013 |
Wang C, Dong J, Zhang Y, Wang F, Gao H, Li P, Wang S, Zhang J. Design, synthesis and biological evaluation of biphenyl urea derivatives as novel VEGFR-2 inhibitors Medchemcomm. 4: 1434. DOI: 10.1039/C3Md00192J |
0.356 |
|
2012 |
He H, Wang N, Zhang J, Zheng L, Zhang Y. Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression Asian Pacific Journal of Cancer Prevention. 13: 2009-2014. PMID 22901163 DOI: 10.7314/Apjcp.2012.13.5.2009 |
0.376 |
|
2012 |
Zhang J, Zhang Y, Pan X, Wang C, Hu Z, Wang S, He L. Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 8: 145-50. PMID 22385184 DOI: 10.2174/157340612800493656 |
0.399 |
|
2012 |
He H, Han S, Zhang T, Zhang J, Wang S, Hou J. Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. Journal of Pharmaceutical and Biomedical Analysis. 62: 196-202. PMID 22260968 DOI: 10.1016/J.Jpba.2011.12.025 |
0.332 |
|
2011 |
Pan X, Wang C, Wang F, Li P, Hu Z, Shan Y, Zhang J. Development of 5-Fluorouracil derivatives as anticancer agents. Current Medicinal Chemistry. 18: 4538-56. PMID 21864282 DOI: 10.2174/092986711797287584 |
0.328 |
|
2011 |
Zhang J, Shan Y, Pan X, He L. Recent Advances in Antiangiogenic Agents with VEGFR as Target Mini-Reviews in Medicinal Chemistry. 11: 920-946. PMID 21762098 DOI: 10.2174/138955711797068355 |
0.352 |
|
2011 |
Zhang J, Shan Y, Pan X, Wang C, Xu W, He L. Molecular docking, 3D-QSAR studies, and in silico ADME prediction of p-aminosalicylic acid derivatives as neuraminidase inhibitors. Chemical Biology & Drug Design. 78: 709-717. PMID 21752201 DOI: 10.1111/J.1747-0285.2011.01179.X |
0.321 |
|
2011 |
Zhang Y, Zheng L, Zhang J, Dai B, Wang N, Chen Y, He L. Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo. Planta Medica. 77: 1774-81. PMID 21614750 DOI: 10.1055/S-0030-1271132 |
0.319 |
|
2011 |
Zhang J, Zhang Y, Pan X, Wang S, He L. Synthesis and cytotoxic evaluation of novel symmetrical taspine derivatives as anticancer agents. Medicinal Chemistry (Shariqah (United Arab Emirates)). 7: 286-94. PMID 21568882 DOI: 10.2174/157340611796150914 |
0.394 |
|
2011 |
Li N, He J, Zhan Y, Zhou N, Zhang J. Design, synthesis and preliminary evaluation of novel imperatorin derivatives as vasorelaxant agents. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 7: 18-23. PMID 21235515 DOI: 10.2174/157340611794072715 |
0.382 |
|
2011 |
Sun M, Zhang Y, Zhang J, Wang S, He L. A high expression EGFR/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Rhizoma Polygoni Cuspidati Acta Pharmaceutica Sinica B. 1: 115-120. DOI: 10.1016/J.Apsb.2011.06.008 |
0.304 |
|
2010 |
Zhang J, Zhang Y, Shan Y, Li N, Ma W, He L. Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents. European Journal of Medicinal Chemistry. 45: 2798-805. PMID 20304537 DOI: 10.1016/J.Ejmech.2010.03.001 |
0.394 |
|
2010 |
Zhang J, Zhang Y, Zhang S, Wang S, He L. Corrigendum to “Discovery of novel taspine derivatives as antiangiogenic agents” [Bioorg. Med. Chem. Lett. 20 (2010) 718] Bioorganic & Medicinal Chemistry Letters. 20: 1797. DOI: 10.1016/J.Bmcl.2010.01.026 |
0.311 |
|
2009 |
Zhang J, Zhang Y, Zhang S, Wang S, He L. Discovery of novel taspine derivatives as antiangiogenic agents. Bioorganic & Medicinal Chemistry Letters. 20: 718-21. PMID 20006929 DOI: 10.1016/J.Bmcl.2009.11.073 |
0.406 |
|
2008 |
Zhang J, Xu W, Liu A, Du G. Design, synthesis, and preliminary evaluation of new pyrrolidine derivatives as neuraminidase inhibitors. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 4: 206-9. PMID 18473912 DOI: 10.2174/157340608784325151 |
0.367 |
|
2008 |
Wang Q, Chen M, Zhu H, Zhang J, Fang H, Wang B, Xu W. Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 16: 5473-81. PMID 18467109 DOI: 10.1016/J.Bmc.2008.04.012 |
0.452 |
|
2008 |
Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 16: 3839-47. PMID 18304821 DOI: 10.1016/J.Bmc.2008.01.036 |
0.345 |
|
2007 |
Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 15: 2749-58. PMID 17287121 DOI: 10.1016/J.Bmc.2007.01.020 |
0.36 |
|
2006 |
Zhang L, Zhang J, Fang H, Wang Q, Xu W. Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors. Bioorganic & Medicinal Chemistry. 14: 8286-94. PMID 17008101 DOI: 10.1016/J.Bmc.2006.09.015 |
0.363 |
|
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