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Agostino Cilibrizzi, PhD - Publications

Affiliations: 
2011 Dipartimento di Scienze Farmaceutiche Università degli Studi di Firenze, Firenze, Toscana, Italy 
 2016 Chemistry Imperial College London, London, England, United Kingdom 
 2011-2013 University of Cambridge, Cambridge, England, United Kingdom 
 2016-2018 Institute of Pharmaceutical Science King's College London, London, UK 
 2019- Comprehensive Cancer Centre King's College London, London, UK 
Area:
organic chemistry
Website:
https://kclpure.kcl.ac.uk/portal/en/persons/agostino-cilibrizzi(0ea0db1b-3181-4197-8fa5-6b8d1c48aedb).html
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hider RC, Pourzand C, Ma Y, Cilibrizzi A. Optical Imaging Opportunities to Inspect the Nature of Cytosolic Iron Pools. Molecules (Basel, Switzerland). 28. PMID 37764245 DOI: 10.3390/molecules28186467  0.62
2023 Jin J, Mazzacuva F, Crocetti L, Giovannoni MP, Cilibrizzi A. PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes. International Journal of Molecular Sciences. 24. PMID 37511275 DOI: 10.3390/ijms241411518  0.586
2023 Ran Y, Moursy M, Hider RC, Cilibrizzi A. The Colorimetric Detection of the Hydroxyl Radical. International Journal of Molecular Sciences. 24. PMID 36835574 DOI: 10.3390/ijms24044162  0.46
2022 Crocetti L, Floresta G, Zagni C, Merugu D, Mazzacuva F, de Oliveira Silva RR, Vergelli C, Giovannoni MP, Cilibrizzi A. Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2)-one as Novel Scaffold for FABP4 Inhibition. Pharmaceuticals (Basel, Switzerland). 15. PMID 36355506 DOI: 10.3390/ph15111335  0.622
2022 Crocetti L, Quinn MT, Cilibrizzi A, Giovannoni MP. Editorial: Serine protease inhibitors and their therapeutic applications. Frontiers in Chemistry. 10: 980152. PMID 36003619 DOI: 10.3389/fchem.2022.980152  0.558
2022 Floresta G, Memdouh S, Pham T, Ma MT, Blower PJ, Hider RC, Abbate V, Cilibrizzi A. Targeting integrin αvβ6 with gallium-68 tris (hydroxypyridinone) based PET probes. Dalton Transactions (Cambridge, England : 2003). PMID 35972045 DOI: 10.1039/d2dt00980c  0.656
2022 Crocetti L, Floresta G, Cilibrizzi A, Giovannoni MP. An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022. Molecules (Basel, Switzerland). 27. PMID 35956914 DOI: 10.3390/molecules27154964  0.577
2022 Cilibrizzi A, Wang JT, Memdouh S, Iacovone A, McElroy K, Jaffar N, Young JD, Hider RC, Blower P, Al-Jamal K, Abbate V. PSMA-targeted NIR probes for image-guided detection of prostate cancer. Colloids and Surfaces. B, Biointerfaces. 218: 112734. PMID 35952398 DOI: 10.1016/j.colsurfb.2022.112734  0.625
2022 Cilibrizzi A, Pourzand C, Abbate V, Reelfs O, Versari L, Floresta G, Hider R. The synthesis and properties of mitochondrial targeted iron chelators. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. PMID 35366134 DOI: 10.1007/s10534-022-00383-8  0.616
2021 Young JD, Ma MT, Eykyn TR, Andrew Atkinson R, Abbate V, Cilibrizzi A, Hider RC, Blower PJ. Corrigendum to "Dipeptide inhibitors of the prostate specific membrane antigen (PSMA): A comparison of urea and thiourea derivatives" [Bioorganic Med. Chem. Lett. 42 (2021) 128044]. Bioorganic & Medicinal Chemistry Letters. 48: 128231. PMID 34229996 DOI: 10.1016/j.bmcl.2021.128231  0.587
2021 Vergelli C, Khlebnikov AI, Crocetti L, Guerrini G, Cantini N, Kirpotina LN, Schepetkin IA, Cilibrizzi A, Quinn MT, Rossi P, Paoli P, Giovannoni MP. Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N-formyl peptide receptors (FPRs) agonists. Chemical Biology & Drug Design. PMID 34148303 DOI: 10.1111/cbdd.13913  0.638
2021 Young JD, Ma MT, Eykyn TR, Atkinson RA, Abbate V, Cilibrizzi A, Hider RC, Blower PJ. Dipeptide Inhibitors of the Prostate Specific Membrane Antigen (PSMA): A Comparison of Urea and Thiourea Derivatives. Bioorganic & Medicinal Chemistry Letters. 128044. PMID 33865971 DOI: 10.1016/j.bmcl.2021.128044  0.657
2020 Czerwinska J, Parkin MC, Cilibrizzi A, George C, Kicman AT, Dargan PI, Abbate V. Pharmacokinetics of Mephedrone Enantiomers in Whole Blood after a Controlled Intranasal Administration to Healthy Human Volunteers. Pharmaceuticals (Basel, Switzerland). 14. PMID 33374623 DOI: 10.3390/ph14010005  0.486
2020 O'Keeffe R, Latunde-Dada GO, Chen YL, Kong XL, Cilibrizzi A, Hider RC. Glutathione and the intracellular labile heme pool. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. PMID 33301081 DOI: 10.1007/s10534-020-00274-w  0.651
2020 Gacesa R, Tripodi AAP, Cilibrizzi A, Leggio A, Hider R, Abbate V. Solid-Phase Synthesis and Analysis of Iron-Binding Catecholato Chelators. International Journal of Molecular Sciences. 21. PMID 33053658 DOI: 10.3390/ijms21207498  0.663
2020 Nielsen CD, Dhasmana D, Floresta G, Wohland T, Cilibrizzi A. Illuminating the Path to Target GPCR Structures and Functions. Biochemistry. PMID 32956586 DOI: 10.1021/Acs.Biochem.0C00606  0.309
2020 Chuljerm H, Deeudom M, Fucharoen S, Mazzacuva F, Hider RC, Srichairatanakool S, Cilibrizzi A. Characterization of two siderophores produced by Bacillus megaterium: A preliminary investigation into their potential as therapeutic agents. Biochimica Et Biophysica Acta. General Subjects. 1864: 129670. PMID 32565293 DOI: 10.1016/J.Bbagen.2020.129670  0.546
2020 Floresta G, Crocetti L, Giovannoni MP, Biagini P, Cilibrizzi A. Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1137-1144. PMID 32367744 DOI: 10.1080/14756366.2020.1760261  0.639
2020 Poeschl A, Mountford DM, Hider RC, Cilibrizzi A. Synthetic Approaches for Piperidone-Based Templates as Scaffolds to Access Chirally Enriched Donepezil Analogues. Acs Omega. 5: 2378-2396. PMID 32064399 DOI: 10.1021/acsomega.9b03808  0.481
2019 Chuljerm H, Chen YL, Srichairatanakool S, Hider RC, Cilibrizzi A. Synthesis and iron coordination properties of schizokinen and its imide derivative. Dalton Transactions (Cambridge, England : 2003). PMID 31742278 DOI: 10.1039/C9Dt02731A  0.68
2019 Reelfs O, Abbate V, Cilibrizzi A, Pook MA, Hider RC, Pourzand C. The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A. Metallomics : Integrated Biometal Science. PMID 30778428 DOI: 10.1039/C8Mt00257F  0.629
2019 Floresta G, Cilibrizzi A, Abbate V, Spampinato A, Zagni C, Rescifina A. FABP4 inhibitors 3D-QSAR model and isosteric replacement of BMS309403 datasets. Data in Brief. 22: 471-483. PMID 30619925 DOI: 10.1016/J.Dib.2018.12.047  0.607
2019 Cilibrizzi A, Floresta G, Abbate V, Giovannoni MP. iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 44-50. PMID 30362379 DOI: 10.1080/14756366.2018.1518960  0.725
2018 Floresta G, Cilibrizzi A, Abbate V, Spampinato A, Zagni C, Rescifina A. 3D-QSAR assisted identification of FABP4 inhibitors: An effective scaffold hopping analysis/QSAR evaluation. Bioorganic Chemistry. 84: 276-284. PMID 30529845 DOI: 10.1016/J.Bioorg.2018.11.045  0.608
2018 Ferraro G, Pica A, Petruk G, Pane F, Amoresano A, Cilibrizzi A, Vilar R, Monti DM, Merlino A. Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites. Nanomedicine (London, England). PMID 30501559 DOI: 10.2217/Nnm-2018-0259  0.58
2018 Cilibrizzi A, Abbate V, Chen YL, Ma Y, Zhou T, Hider RC. Hydroxypyridinone Journey into Metal Chelation. Chemical Reviews. PMID 30033720 DOI: 10.1021/Acs.Chemrev.8B00254  0.757
2018 Ferraro G, Marzo T, Infrasca T, Cilibrizzi A, Vilar R, Messori L, Merlino A. A case of extensive protein platination: the reaction of lysozyme with a Pt(ii)-terpyridine complex. Dalton Transactions (Cambridge, England : 2003). PMID 29904761 DOI: 10.1039/C8Dt01254G  0.563
2018 Cilibrizzi A. Correspondence: Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury. Nature Communications. 9: 531. PMID 29416027 DOI: 10.1038/S41467-017-02654-2  0.315
2017 Crocetti L, Bartolucci G, Cilibrizzi A, Giovannoni MP, Guerrini G, Iacovone A, Menicatti M, Schepetkin IA, Khlebnikov AI, Quinn MT, Vergelli C. Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors. Chemistry Central Journal. 11: 127. PMID 29214393 DOI: 10.1186/S13065-017-0358-1  0.652
2017 Apirakkan O, Frinculescu A, Shine T, Parkin MC, Cilibrizzi A, Frascione N, Abbate V. Analytical characterization of three cathinone derivatives, 4-MPD, 4 F-PHP and bk-EPDP, purchased as bulk powder from online vendors. Drug Testing and Analysis. PMID 28544816 DOI: 10.1002/Dta.2218  0.59
2017 Cilibrizzi A, Fedorova M, Collins J, Leatherbarrow R, Woscholski R, Vilar R. A tri-functional vanadium(iv) complex to detect cysteine oxidation. Dalton Transactions (Cambridge, England : 2003). PMID 28513686 DOI: 10.1039/C7Dt00076F  0.732
2017 Cilibrizzi A, Terenghi M, Fedorova M, Woscholski R, Klug D, Vilar R. Small-molecule optical probes for cell imaging of protein sulfenylation and their application to monitor cisplatin induced protein oxidation Sensors and Actuators B: Chemical. 248: 437-446. DOI: 10.1016/J.Snb.2017.03.171  0.718
2016 Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Ye RD, Quinn MT. Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists. Drug Development Research. PMID 27859446 DOI: 10.1002/Ddr.21370  0.669
2016 Wilson N, Mak LH, Cilibrizzi A, Gee AD, Long NJ, Woscholski R, Vilar R. A lipophilic copper(ii) complex as an optical probe for intracellular detection of NO. Dalton Transactions (Cambridge, England : 2003). PMID 27792231 DOI: 10.1039/C6Dt02880B  0.724
2016 Vergelli C, Schepetkin IA, Ciciani G, Cilibrizzi A, Crocetti L, Giovannoni MP, Guerrini G, Iacovone A, Kirpotina LN, Khlebnikov AI, Ye RD, Quinn MT. 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists. Bioorganic & Medicinal Chemistry. PMID 27134116 DOI: 10.1016/J.Bmc.2016.04.019  0.656
2016 Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar R. Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies. Dalton Transactions (Cambridge, England : 2003). 45: 7104-13. PMID 27008377 DOI: 10.1039/C5Dt04753F  0.737
2015 Vergelli C, Ciciani G, Cilibrizzi A, Crocetti L, Di Cesare Mannelli L, Ghelardini C, Guerrini G, Iacovone A, Giovannoni MP. Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents. Bioorganic & Medicinal Chemistry. 23: 6237-45. PMID 26361735 DOI: 10.1016/J.Bmc.2015.08.043  0.646
2015 Giovannoni MP, Schepetkin IA, Crocetti L, Ciciani G, Cilibrizzi A, Guerrini G, Khlebnikov AI, Quinn MT, Vergelli C. Cinnoline derivatives as human neutrophil elastase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-12. PMID 26194018 DOI: 10.3109/14756366.2015.1057718  0.677
2015 Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C. Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists. European Journal of Medicinal Chemistry. 89: 32-41. PMID 25462223 DOI: 10.1016/J.Ejmech.2014.10.020  0.649
2015 Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C. Further studies on pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists European Journal of Medicinal Chemistry. 89: 32-41. DOI: 10.1016/j.ejmech.2014.10.020  0.584
2015 Vergelli C, Ciciani G, Cilibrizzi A, Crocetti L, Di Cesare Mannelli L, Ghelardini C, Guerrini G, Iacovone A, Giovannoni MP. Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents Bioorganic and Medicinal Chemistry. 23: 6237-6245. DOI: 10.1016/j.bmc.2015.08.043  0.614
2014 Schepetkin IA, Khlebnikov AI, Giovannoni MP, Kirpotina LN, Cilibrizzi A, Quinn MT. Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition Current Medicinal Chemistry. 21: 1478-1504. PMID 24350845 DOI: 10.2174/0929867321666131218095521  0.648
2013 Crocetti L, Schepetkin IA, Cilibrizzi A, Graziano A, Vergelli C, Giomi D, Khlebnikov AI, Quinn MT, Giovannoni MP. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. Journal of Medicinal Chemistry. 56: 6259-72. PMID 23844670 DOI: 10.1021/Jm400742J  0.662
2013 Cilibrizzi A, Crocetti L, Giovannoni MP, Graziano A, Vergelli C, Bartolucci G, Soldani G, Quinn MT, Schepetkin IA, Faggi C. Synthesis, HPLC enantioresolution, and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) agonists. Chirality. 25: 400-8. PMID 23744588 DOI: 10.1002/Chir.22162  0.645
2013 Giovannoni MP, Schepetkin IA, Cilibrizzi A, Crocetti L, Khlebnikov AI, Dahlgren C, Graziano A, Dal Piaz V, Kirpotina LN, Zerbinati S, Vergelli C, Quinn MT. Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists. European Journal of Medicinal Chemistry. 64: 512-28. PMID 23685570 DOI: 10.1016/J.Ejmech.2013.03.066  0.667
2013 Crocetti L, Vergelli C, Cilibrizzi A, Graziano A, Khlebnikov AI, Kirpotina LN, Schepetkin IA, Quinn MT, Giovannoni MP. Synthesis and pharmacological evaluation of new pyridazin-based thioderivatives as formyl peptide receptor (FPR) agonists Drug Development Research. 74: 259-271. DOI: 10.1002/Ddr.21076  0.668
2012 Graziano A, Giovannoni MP, Cilibrizzi A, Crocetti L, Piaz VD, Vergelli C, Trincavelli ML, Martini C, Giacomelli C. New Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones Fluoroderivatives as Human A1 Adenosine Receptor Ligands. Acta Chimica Slovenica. 59: 648-55. PMID 24061322  0.614
2012 Cilibrizzi A, Schepetkin IA, Bartolucci G, Crocetti L, Dal Piaz V, Giovannoni MP, Graziano A, Kirpotina LN, Quinn MT, Vergelli C. Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. Bioorganic & Medicinal Chemistry. 20: 3781-92. PMID 22607879 DOI: 10.1016/J.Bmc.2012.04.043  0.66
2012 Cilibrizzi A, Isidro-Llobet A, Mateu N, Galloway WRJD, Spring DR. Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/ t -Bu solid-phase strategy Synlett. 290-294. DOI: 10.1055/S-0031-1290119  0.51
2012 Vergelli C, Cilibrizzi A, Crocetti L, Graziano A, Dal Piaz V, Wan B, Wang Y, Franzblau S, Giovannoni MP. Synthesis and Evaluation as Antitubercular Agents of 5-Arylethenyl and 5-(Hetero)aryl-3-Isoxazolecarboxylate Drug Development Research. 74: 162-172. DOI: 10.1002/Ddr.21057  0.653
2011 Crocetti L, Giovannoni MP, Schepetkin IA, Quinn MT, Khlebnikov AI, Cilibrizzi A, Piaz VD, Graziano A, Vergelli C. Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Bioorganic & Medicinal Chemistry. 19: 4460-72. PMID 21741848 DOI: 10.1016/J.Bmc.2011.06.036  0.653
2011 Isidro-Llobet A, Murillo T, Bello P, Cilibrizzi A, Hodgkinson JT, Galloway WR, Bender A, Welch M, Spring DR. Diversity-oriented synthesis of macrocyclic peptidomimetics. Proceedings of the National Academy of Sciences of the United States of America. 108: 6793-8. PMID 21383137 DOI: 10.1073/Pnas.1015267108  0.581
2010 Giovannoni MP, Vergelli C, Cilibrizzi A, Crocetti L, Biancalani C, Graziano A, Dal Piaz V, Loza MI, Cadavid MI, Díaz JL, Gavaldà A. Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands. Bioorganic & Medicinal Chemistry. 18: 7890-9. PMID 20937560 DOI: 10.1016/J.Bmc.2010.09.043  0.642
2010 Biagini P, Biancalani C, Graziano A, Cesari N, Giovannoni MP, Cilibrizzi A, Dal Piaz V, Vergelli C, Crocetti L, Delcanale M, Armani E, Rizzi A, Puccini P, Gallo PM, Spinabelli D, et al. Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity. Bioorganic & Medicinal Chemistry. 18: 3506-17. PMID 20413313 DOI: 10.1016/J.Bmc.2010.03.066  0.655
2010 Giovannoni MP, Graziano A, Matucci R, Nesi M, Cesari N, Vergelli C, Biancalani C, Crocetti L, Cilibrizzi A, Dal Piaz V. Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives Drug Development Research. 72: 274-288. DOI: 10.1002/Ddr.20395  0.639
2009 Biancalani C, Giovannoni MP, Pieretti S, Cesari N, Graziano A, Vergelli C, Cilibrizzi A, Di Gianuario A, Colucci M, Mangano G, Garrone B, Polenzani L, Dal Piaz V. Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain. Journal of Medicinal Chemistry. 52: 7397-409. PMID 19788200 DOI: 10.1021/Jm900458R  0.621
2009 Cilibrizzi A, Quinn MT, Kirpotina LN, Schepetkin IA, Holderness J, Ye RD, Rabiet MJ, Biancalani C, Cesari N, Graziano A, Vergelli C, Pieretti S, Dal Piaz V, Giovannoni MP. 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. Journal of Medicinal Chemistry. 52: 5044-57. PMID 19639995 DOI: 10.1021/Jm900592H  0.66
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